Personnel Information

写真a

YASUDA Shinsuke


Job title

Professor

Research Areas, Keywords

rheumatoid arthritis, systemic lupus erythematosus, antiphospholipid syndrome, polymyositis, dermatomyositis
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Graduating School 【 display / non-display 】

  • Hokkaido University, Faculty of Medicine, 1994.03, Graduated

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Graduate School 【 display / non-display 】

  • Hokkaido University, Graduate School, Division of Medicine, Doctor's Course, 2001.03, Completed

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Campus Career 【 display / non-display 】

  • 2020.01
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Environmental Response， Rheumatology， Professor
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External Career 【 display / non-display 】

  • 1994.05
    -
    1995.03
    Hokkaido University Hospital, Department of Medicine II, Senior Resident
  • 1997.04
    -
    2001.03
    , Graduate Student
  • 2001.04
    -
    2003.08
    Brigham & Women's Hospital, Harvard Medical School, Division Immunology, Rhaumatology and Allergy, Postdoctoral researcher
  • 2003.09
    -
    2004.03
    Hokkaido University Hospital, Department of Medicine II, Senior Resident
  • 2004.04
    -
    2007.03
    Hokkaido University Graduate School of Medicine, Department of Medicine II, Assistant Professor
  • 2007.04
    -
    2012.03
    Hokkaido University Graduate School of Medicine, Department of Medicine II, Assistant Professor
  • 2012.04
    -
    2016.06
    Hokkaido University Graduate School of Medicine, Department of Medicine II, Junior Associate Professor
  • 2016.07
    -
    2019.12
    Hokkaido University, Graduate School of Medicine, Associate Professor
  • 2016.07
    -
    2019.12
    Hokkaido University Graduate School of Medicine, Department of Medicine II, Associate Professor
  • 2020.01
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Professor

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Research Areas 【 display / non-display 】

  • Connective tissue disease and allergy

  • Connective tissue disease and allergy

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Qualification Acquired 【 display / non-display 】

  • Doctor

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Research Theme 【 display / non-display 】

  • The mechanism how RasGRP4 promotes proliferation of synovial fibroblasts in rheumatoid arthritis, 2015.10 - 2018.03

  • Establishment of Molecular Imaging and Lipidomics Technologies for Early Diagnosis of Atherosclerotic Disease, 2014.04 - 2017.03

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Published Papers & Misc 【 display / non-display 】

  1. Keisuke Tanaka, Ayako Ichikawa, Natsuka Umezawa, Kouhei Yamamoto, Kota Yoshifuji, Keigo Okada, Ayako Nogami, Yoshihiro Umezawa, Toshikage Nagao, Chizuko Sakashita, Takehiko Mori, Shuji Tohda, Ryuji Koike, Shinsuke Yasuda, Masahide Yamamoto. Lymphoproliferative disorder risk after methotrexate treatment for rheumatoid arthritis. Cancer Sci. 2023.09; 114 (9): 3719-3727. ( PubMed, DOI )

  2. Apple-shaped obesity: A risky soil for cytokine-accelerated severity in COVID-19. 2023.05; 120 (22): e2300155120. ( PubMed, DOI )

  3. Hemorrhagic gastric ulcer in a patient with Behcet's disease successfully treated with infliximab. 2023.04; 3 (1): e196. ( PubMed, DOI )

  4. A novel gain-of-function missense variant in PLCG2 associated with autoinflammation and hypergammaglobulinemia. 2023.04; ( PubMed, DOI )

  5. Factors associated with impaired physical function in elderly rheumatoid arthritis patients who had achieved low disease activity. 2022.12; ( PubMed, DOI )

  6. Correction: CD34+THY1+ synovial fibroblast subset in arthritic joints has high osteoblastic and chondrogenic potentials in vitro. 2022.09; 24 (1): 224. ( PubMed, DOI )

  7. An adult case of suspected A20 haploinsufficiency mimicking polyarteritis nodosa. 2022.05; 61 (11): e337-e340. ( PubMed, DOI )

  8. Cost-Effectiveness Analyses of Biologic and Targeted Synthetic Disease-Modifying Anti-Rheumatic Diseases in Patients With Rheumatoid Arthritis: Three Approaches with a Cohort Simulation and Real-World Data. 2022.04; ( PubMed, DOI )

  9. Associated factors with poor treatment response to initial glucocorticoid therapy in patients with adult-onset Still's disease. 2022.04; 24 (1): 92. ( PubMed, DOI )

  10. Sei Muraoka, Zento Yamada, Mai Kawazoe, Wataru Hirose, Hajime Kono, Shinsuke Yasuda, Yukiko Komano, Hiroshi Kawano, Toshihiko Hidaka, Shusaku Nakashima, Tsuyoshi Kasama, Tamio Teramoto, Toshihiro Nanki, . Abatacept is Efficacious in the Treatment of Older Patients with csDMARD-Refractory Rheumatoid Arthritis: A Prospective, Multicenter, Observational Study. Rheumatol Ther. 2021.12; 8 (4): 1585-1601. ( PubMed, DOI )

  11. Yuichiro Fujieda, Tetsuya Horita, Naoki Nishimoto, Kazuhide Tanimura, Yoshiharu Amasaki, Hideki Kasahara, Shin Furukawa, Tsuyoshi Takeda, Shinji Fukaya, Kazuo Matsui, Akito Tsutsumi, Akira Furusaki, Akira Sagawa, Kou Katayama, Kaoru Takeuchi, Kazuaki Katsumata, Takashi Kurita, Peter Shane, Masaru Kato, Kenji Oku, Shinsuke Yasuda, Masahiko Takahata, Norimasa Iwasaki, Tatsuya Atsumi. Efficacy and safety of sodium RISedronate for glucocorticoid-induced OsTeoporosis with rheumaTOid arthritis (RISOTTO study): A multicentre, double-blind, randomized, placebo-controlled trial. Mod Rheumatol. 2021.05; 31 (3): 593-599. ( PubMed, DOI )

  12. Yoshiya Tanaka, Hideto Kameda, Kazuyoshi Saito, Yuko Kaneko, Eiichi Tanaka, Shinsuke Yasuda, Naoto Tamura, Keishi Fujio, Takao Fujii, Toshihisa Kojima, Tatsuhiko Anzai, Chikuma Hamada, Yoshihisa Fujino, Shinya Matsuda, Hitoshi Kohsaka. Response to tocilizumab and work productivity in patients with rheumatoid arthritis: 2-year follow-up of FIRST ACT-SC study. Mod Rheumatol. 2021.01; 31 (1): 42-52. ( PubMed, DOI )

  13. Wen Shi Lee, Shinsuke Yasuda, Michihiro Kono, Yuki Kudo, Sanae Shimamura, Michihito Kono, Yuichiro Fujieda, Masaru Kato, Kenji Oku, Tomohiro Shimizu, Tomohiro Onodera, Norimasa Iwasaki, Tatsuya Atsumi. MicroRNA-9 ameliorates destructive arthritis through down-regulation of NF-κB1-RANKL pathway in fibroblast-like synoviocytes. Clinical immunology (Orlando, Fla.). 2020.03; 212 108348. ( PubMed, DOI )

  14. Nobuya Abe, Masaru Kato, Michihito Kono, Yuichiro Fujieda, Hiroshi Ohira, Ichizo Tsujino, Noriko Oyama-Manabe, Kenji Oku, Toshiyuki Bohgaki, Shinsuke Yasuda, Tatsuya Atsumi. Right ventricular dimension index by cardiac magnetic resonance for prognostication in connective tissue diseases and pulmonary hypertension. Rheumatology (Oxford, England). 2020.03; 59 (3): 622-633. ( PubMed, DOI )

  15. Yuichiro Fujieda, Mototsugu Doi, Takuya Asaka, Masahiro Ota, Ryo Hisada, Naoki Ohnishi, Michihiro Kono, Hiraku Kameda, Daigo Nakazawa, Masaru Kato, Olga Amengual, Masahiko Takahata, Shinsuke Yasuda, Yoshimasa Kitagawa, Tatsuya Atsumi. Incidence and risk of antiresorptive agent-related osteonecrosis of the jaw (ARONJ) after tooth extraction in patients with autoimmune disease. Journal of bone and mineral metabolism. 2020.02; ( PubMed, DOI )

  16. Kohei Karino, Michihiro Kono, Michihito Kono, Keita Sakamoto, Yuichiro Fujieda, Masaru Kato, Olga Amengual, Kenji Oku, Shinsuke Yasuda, Tatsuya Atsumi. Myofascia-dominant involvement on whole-body MRI as a risk factor for rapidly progressive interstitial lung disease in dermatomyositis. Rheumatology (Oxford, England). 2020.01; ( PubMed, DOI )

  17. Ryo Hisada, Masaru Kato, Eri Sugawara, Masatoshi Kanda, Yuichiro Fujieda, Kenji Oku, Toshiyuki Bohgaki, Olga Amengual, Tetsuya Horita, Shinsuke Yasuda, Tatsuya Atsumi. Circulating plasmablasts contribute to antiphospholipid antibody production, associated with type I interferon upregulation. Journal of thrombosis and haemostasis : JTH. 2019.07; 17 (7): 1134-1143. ( PubMed, DOI )

  18. Kazumasa Ohmura, Kenji Oku, Tamao Kitaori, Olga Amengual, Ryo Hisada, Masatoshi Kanda, Yuka Shimizu, Yuichiro Fujieda, Masaru Kato, Toshiyuki Bohgaki, Tetsuya Horita, Shinsuke Yasuda, Mayumi Sugiura-Ogasawara, Tatsuya Atsumi. Pathogenic roles of anti-C1q antibodies in recurrent pregnancy loss. Clinical immunology (Orlando, Fla.). 2019.06; 203 37-44. ( PubMed, DOI )

  19. FACTORS THAT AFFECT THE RESPONSE TO TOCILIZUMAB WITH REGARD TO WORK PRODUCTIVITY IN PATIENTS WITH RHEUMATOID ARTHRITIS: A 2-YEAR FOLLOW-UP OF THE FIRST ACT-SC STUDY 2019.06; 78 1667. ( DOI )

  20. Kanako Watanabe-Kusunoki, Nobuya Abe, Daigo Nakazawa, Kohei Karino, Fumihiko Hattanda, Yuichiro Fujieda, Saori Nishio, Shinsuke Yasuda, Akihiro Ishizu, Tatsuya Atsumi. A case report dysregulated neutrophil extracellular traps in a patient with propylthiouracil-induced anti-neutrophil cytoplasmic antibody-associated vasculitis. Medicine. 2019.04; 98 (17): e15328. ( PubMed, DOI )

  21. Nobuya Abe, Yuichiro Fujieda, Kentaro Nagaoka, Misako Ohkusu, Shinsuke Yasuda, Katsuhiko Kamei, Tatsuya Atsumi. Disseminated Cryptococcosis with Bronchiolitis and Cellulitis. American journal of respiratory and critical care medicine. 2019.01; 199 (2): 235-236. ( PubMed, DOI )

  22. Michihiro Kono, Takashi Kurita, Shinsuke Yasuda, Michihito Kono, Yuichiro Fujieda, Toshiyuki Bohgaki, Takayuki Katsuyama, George C Tsokos, Vaishali R Moulton, Tatsuya Atsumi. Decreased Expression of Serine/Arginine-Rich Splicing Factor 1 in T Cells From Patients With Active Systemic Lupus Erythematosus Accounts for Reduced Expression of RasGRP1 and DNA Methyltransferase 1. Arthritis & rheumatology (Hoboken, N.J.). 2018.12; 70 (12): 2046-2056. ( PubMed, DOI )

  23. Hiroyuki Nakamura, Sanae Shimamura, Shinsuke Yasuda, Michihito Kono, Michihiro Kono, Yuichiro Fujieda, Masaru Kato, Kenji Oku, Toshiyuki Bohgaki, Tomohiro Shimizu, Norimasa Iwasaki, Tatsuya Atsumi. Ectopic RASGRP2 (CalDAG-GEFI) expression in rheumatoid synovium contributes to the development of destructive arthritis. Annals of the rheumatic diseases. 2018.12; 77 (12): 1765-1772. ( PubMed, DOI )

  24. Shun Tanimura, Yuichiro Fujieda, Michihiro Kono, Yuhei Shibata, Ryo Hisada, Eri Sugawara, Hiroyuki Nakamura, Kazumasa Ohmura, Sanae Shimamura, Asako Mitani, Haruki Shida, Toshiyuki Watanabe, Masaru Kato, Kenji Oku, Toshiyuki Bohgaki, Olga Amengual, Shinsuke Yasuda, Chikara Shimizu, Tatsuya Atsumi. Clinical significance of plasma presepsin levels in patients with systemic lupus erythematosus. Modern rheumatology. 2018.09; 28 (5): 865-871. ( PubMed, DOI )

  25. Shimizu Y, Yasuda S, Kimura T, Nishio S, Kono M, Ohmura K, Shimamura S, Kono M, Fujieda Y, Kato M, Oku K, Bohgaki T, Fukasawa Y, Tanaka S, Atsumi T. Interferon-inducible Mx1 protein is highly expressed in renal tissues from treatment-naïve lupus nephritis, but not in those under immunosuppressive treatment. Modern rheumatology. 2018.07; 28 (4): 661-669. ( PubMed, DOI )

  26. M. Kono, S. Yasuda, M. Kono, T. Atsumi. Tocilizumab reduced production of systemic sclerosis-related autoantibodies and anti-cyclic citrullinated protein antibodies in two patients with overlapping systemic sclerosis and rheumatoid arthritis Scandinavian Journal of Rheumatology. 2018.05; 47 (3): 248-250. ( PubMed, DOI )

  27. Kazumasa Ohmura, Masaru Kato, Toshiyuki Watanabe, Kenji Oku, Toshiyuki Bohgaki, Tetsuya Horita, Shinsuke Yasuda, Yoichi M Ito, Norihiro Sato, Tatsuya Atsumi. Effect of combined treatment with bisphosphonate and vitamin D on atherosclerosis in patients with systemic lupus erythematosus: a propensity score-based analysis. Arthritis research & therapy. 2018.04; 20 (1): 72. ( PubMed, DOI )

  28. Hiroyuki Nakamura, Kenji Oku, Olga Amengual, Kazumasa Ohmura, Yuichiro Fujieda, Masaru Kato, Toshiyuki Bohgaki, Shinsuke Yasuda, Tatsuya Atsumi. First-Line, Non-Criterial Antiphospholipid Antibody Testing for the Diagnosis of Antiphospholipid Syndrome in Clinical Practice: A Combination of Anti-β2 -Glycoprotein I Domain I and Anti-Phosphatidylserine/Prothrombin Complex Antibodies Tests. Arthritis care & research. 2018.04; 70 (4): 627-634. ( PubMed, DOI )

  29. Hiroyuki Nakamura, Kenji Oku, Yusuke Ogata, Kazumasa Ohmura, Yoko Yoshida, Etsuko Kitano, Yuichiro Fujieda, Masaru Kato, Toshiyuki Bohgaki, Olga Amengual, Shinsuke Yasuda, Yoshihiro Fujimura, Tsukasa Seya, Tatsuya Atsumi. Alternative pathway activation due to low level of complement factor H in primary antiphospholipid syndrome. Thrombosis research. 2018.04; 164 63-68. ( PubMed, DOI )

  30. Masaru Kato, Shinsuke Yasuda, Tatsuya Atsumi. The role of genetics and epigenetics in rheumatic diseases: are they really a target to be aimed at? Rheumatology International. 2018.04; 38 (8): 1-6. ( PubMed, DOI )

  31. T. Watanabe, K. Oku, O. Amengual, R. Hisada, K. Ohmura, I. Nakagawa, H. Shida, T. Bohgaki, T. Horita, S. Yasuda, T. Atsumi. Effects of statins on thrombosis development in patients with systemic lupus erythematosus and antiphospholipid antibodies Lupus. 2018.02; 27 (2): 225-234. ( PubMed, DOI )

  32. Simone Mader, Venkatesh Jeganathan, Yoshiyuki Arinuma, Yuichiro Fujieda, Irena Dujmovic, Jelena Drulovic, Yuka Shimizu, Yuko Sakuma, Joel N. H. Stern, Cynthia Aranow, Meggan Mackay, Shinsuke Yasuda, Tatsuya Atsumi, Shunsei Hirohata, Betty Diamond. Understanding the Antibody Repertoire in Neuropsychiatric Systemic Lupus Erythematosus and Neuromyelitis Optica Spectrum Disorder: Do They Share Common Targets? Arthritis and Rheumatology. 2018.02; 70 (2): 277-286. ( PubMed, DOI )

  33. Hiroyuki Nakamura, Masaru Kato, Toshitaka Nakaya, Michihiro Kono, Shun Tanimura, Takahiro Sato, Yuichiro Fujieda, Kenji Oku, Hiroshi Ohira, Toshiyuki Bohgaki, Shinsuke Yasuda, Ichizo Tsujino, Masaharu Nishimura, Tatsuya Atsumi. Decreased haptoglobin levels inversely correlated with pulmonary artery pressure in patients with pulmonary arterial hypertension: A cross-sectional study MEDICINE. 2017.10; 96 (43): e8349. ( PubMed, DOI )

  34. Hiroyuki Nakamura, Shinsuke Yasuda, Atsushi Noguchi, Toshio Odani, Yuichiro Fujieda, Masaru Kato, Kenji Oku, Junichi Sugita, Toshiyuki Bohgaki, Tomoyuki Endo, Takanori Teshima, Tatsuya Atsumi. Long-Term Follow-up Report on Japanese Patients with Severe Systemic Sclerosis after Autologous Hematopoietic Stem Cell Transplantation ARTHRITIS & RHEUMATOLOGY. 2017.10; 69

  35. Yoshiya Tanaka, Hideto Kameda, Kazuyoshi Saito, Yuko Kaneko, Eiichi Tanaka, Shinsuke Yasuda, Naoto Tamura, Keishi Fujio, Takao Fujii, Toshihisa Kojima, Tatsuhiko Anzai, Chikuma Hamada, Yoshihisa Fujino, Shinya Matsuda, Hitoshi Kohsaka. Improvement in Overall Work Productivity Among Biologic-NaiVe Patients with Rheumatoid Arthritis Treated with Tocilizumab Subcutaneous Injection: A Prospective, Real World, Observational Study in Japan ARTHRITIS & RHEUMATOLOGY. 2017.10; 69

  36. Nobuya Abe, Kenji Oku, Olga Amengual, Yuichiro Fujieda, Masaru Kato, Toshiyuki Bohgaki, Shinsuke Yasuda, Rintaro Mori, Eriko Morishita, Katsue Suzuki-Inoue, Tatsuya Atsumi. Possible Therapeutics for Antiphospholipid Antibody Related Thrombocytopenia: A Systemic Review and Meta-Analysis ARTHRITIS & RHEUMATOLOGY. 2017.10; 69

  37. R. Hisada, M. Kato, E. Sugawara, Y. Fujieda, K. Oku, T. Bohgaki, O. Amengual, S. Yasuda, T. Atsumi. Thrombotic risk stratification by platelet count in patients with antiphospholipid antibodies: a longitudinal study JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2017.09; 15 (9): 1782-1787. ( PubMed, DOI )

  38. Tatsuya Atsumi, Yoshiya Tanaka, Kazuhiko Yamamoto, Tsutomu Takeuchi, Hisashi Yamanaka, Naoki Ishiguro, Katsumi Eguchi, Akira Watanabe, Hideki Origasa, Shinsuke Yasuda, Yuji Yamanishi, Yasuhiko Kita, Tsukasa Matsubara, Masahiro Iwamoto, Toshiharu Shoji, Osamu Togo, Toshiyuki Okada, Desiree van der Heijde, Nobuyuki Miyasaka, Takao Koike. Clinical benefit of 1-year certolizumab pegol (CZP) add-on therapy to methotrexate treatment in patients with early rheumatoid arthritis was observed following CZP discontinuation: 2-year results of the C-OPERA study, a phase III randomised trial ANNALS OF THE RHEUMATIC DISEASES. 2017.08; 76 (8): 1348-1356. ( PubMed, DOI )

  39. Kenji Oku, Olga Amengual, Shinsuke Yasuda, Tatsuya Atsumi. How to Identify High-Risk APS Patients: Clinical Utility and Predictive Values of Validated Scores CURRENT RHEUMATOLOGY REPORTS. 2017.08; 19 (8): 51. ( PubMed, DOI )

  40. H. Nakamura, O. Amengual, T. Horita, M. Kato, K. Oku, T. Bohgaki, S. Yasuda, T. Atsumi. Acute aortic thrombosis related to antiphospholipid antibodies LUPUS. 2017.06; 26 (7): 783-784. ( PubMed, DOI )

  41. R. Hisada, M. Kato, N. Ohnishi, M. Kono, S. Tanimura, E. Sugawara, H. Nakamura, K. Ohmura, S. Shimamura, Y. Fujieda, K. Oku, T. Bohgaki, O. Amengual, S. Yasuda, T. Atsumi. HIGH RISK OF IDIOPATHIC OSTEONECROSIS IN SLE PATIENTS WITH HIGH ANTIPHOSPHOLIPID SCORE AND HYPERTRIGLYCERIDEMIA ANNALS OF THE RHEUMATIC DISEASES. 2017.06; 76 598. ( DOI )

  42. K. Ohmura, K. Oku, T. Kitaori, M. Kono, S. Tanimura, E. Sugawara, R. Hisada, H. Nakamura, S. Shimamura, Y. Fujieda, M. Kato, T. Bohgaki, O. Amengual, S. Yasuda, M. Sugiura-Ogasawara, T. Atsumi. AUTOANTIBODY AGAINST COMPLEMENT COMPONENT 1Q SUBCOMPONENT IS ASSOCIATED WITH THE PATHOGENESIS OF RECURRENT PREGNANCY LOSS ANNALS OF THE RHEUMATIC DISEASES. 2017.06; 76 1453-1454. ( DOI )

  43. H. Nakamura, M. Kato, M. Kono, S. Tanimura, R. Hisada, E. Sugawara, K. Ohmura, S. Shimamura, Y. Fujieda, K. Oku, T. Bohgaki, O. Amengual, S. Yasuda, T. Atsumi. USEFULNESS OF SERUM HAPTOGLOBIN LEVELS AS A NOVEL MARKER FOR PULMONARY ARTERIAL HYPERTENSION COMPLICATED WITH CONNECTIVE TISSUE DISEASE ANNALS OF THE RHEUMATIC DISEASES. 2017.06; 76 624-625. ( DOI )

  44. Shinsuke Yasuda, Yuka Shimizu, Tatsuya Atsumi. Brain MRI abnormalities defined as risks for poor prognosis in lupus patients with acute confusional state: Are they antibody mediated? MODERN RHEUMATOLOGY. 2017.03; 27 (2): 191-192. ( PubMed, DOI )

  45. Michihiro Kono, Shinsuke Yasuda, Tatsuya Atsumi. Takayasu Arteritis with Varied-size Vessel Involvement JOURNAL OF RHEUMATOLOGY. 2017.01; 44 (1): 125-126. ( PubMed, DOI )

  46. Atsushi Noguchi, Masaru Kato, Michihito Kono, Kazumasa Ohmura, Hiroshi Ohira, Ichizo Tsujino, Noriko Oyama-Manabe, Kenji Oku, Toshiyuki Bohgaki, Tetsuya Horita, Shinsuke Yasuda, Masaharu Nishimura, Tatsuya Atsumi. Bi-ventricular interplay in patients with systemic sclerosis-associated pulmonary arterial hypertension: Detection by cardiac magnetic resonance MODERN RHEUMATOLOGY. 2017; 27 (3): 481-488. ( PubMed, DOI )

  47. Eri Sugawara, Masaru Kato, Ryo Hisada, Kenji Oku, Toshiyuki Bohgaki, Tetsuya Horita, Shinsuke Yasuda, Tatsuya Atsumi. Treatment of Vasodilator-resistant Mixed Connective Tissue Disease-associated Pulmonary Arterial Hypertension with Glucocorticoid and Cyclophosphamide INTERNAL MEDICINE. 2017; 56 (4): 445-448. ( PubMed, DOI )

  48. Shinsuke Yasuda, Kazumasa Ohmura, Hiroshi Kanazawa, Takashi Kurita, Yujiro Kon, Tomonori Ishii, Yuichiro Fujieda, Satoshi Jodo, Kazuhide Tanimura, Michio Minami, Tomomasa Izumiyama, Takumi Matsumoto, Yoshiharu Amasaki, Yoko Suzuki, Hideki Kasahara, Naofumi Yamauchi, Masaru Kato, Tamotsu Kamishima, Akito Tsutsumi, Hiromitsu Takemori, Takao Koike, Tatsuya Atsumi. Maintenance treatment using abatacept with dose reduction after achievement of low disease activity in patients with rheumatoid arthritis (MATADOR) - A prospective, multicenter, single arm pilot clinical trial MODERN RHEUMATOLOGY. 2017; 27 (6): 930-937. ( PubMed, DOI )

  49. Michihito Kono, Tamotsu Kamishima, Shinsuke Yasuda, Keita Sakamoto, Sawako Abe, Atsushi Noguchi, Toshiyuki Watanabe, Yuka Shimizu, Kenji Oku, Toshiyuki Bohgaki, Olga Amengual, Tetsuya Horita, Tatsuya Atsumi. Effectiveness of whole-body magnetic resonance imaging for the efficacy of biologic anti-rheumatic drugs in patients with rheumatoid arthritis: A retrospective pilot study MODERN RHEUMATOLOGY. 2017; 27 (6): 953-960. ( PubMed, DOI )

  50. Fumio Hirano, Waka Yokoyama, Hayato Yamazaki, Koichi Amano, Atsushi Kawakami, Taichi Hayashi, Naoto Tamura, Shinsuke Yasuda, Hiroaki Dobashi, Takao Fujii, Satoshi Ito, Yuko Kaneko, Toshihiro Matsui, Yasuaki Okuda, Kazuyoshi Saito, Fumihito Suzuki, Ryusuke Yoshimi, Ryoko Sakai, Ryuji Koike, Hitoshi Kohsaka, Nobuyuki Miyasaka, Masayoshi Harigai. Achieving simplified disease activity index remission in patients with active rheumatoid arthritis is associated with subsequent good functional and structural outcomes in a real-world clinical setting under a treat-to-target strategy MODERN RHEUMATOLOGY. 2017; 27 (5): 811-819. ( PubMed, DOI )

  51. Honda Y, Nagai T, Ikeda Y, Sakakibara M, Asakawa N, Nagano N, Nakai M, Nishimura K, Sugano Y, Ohta-Ogo K, Asaumi Y, Aiba T, Kanzaki H, Kusano K, Noguchi T, Yasuda S, Tsutsui H, Ishibashi-Ueda H, Anzai T. Myocardial Immunocompetent Cells and Macrophage Phenotypes as Histopathological Surrogates for Diagnosis of Cardiac Sarcoidosis in Japanese. Journal of the American Heart Association. 2016.11; 5 (11): ( PubMed, DOI )

  52. Otomo K, Amengual O, Fujieda Y, Nakagawa H, Kato M, Oku K, Horita T, Yasuda S, Matsumoto M, Nakayama KI, Hatakeyama S, Koike T, Atsumi T. Role of apolipoprotein B100 and oxidized low-density lipoprotein in the monocyte tissue factor induction mediated by anti-β2 glycoprotein I antibodies. Lupus. 2016.10; 25 (12): 1288-1298. ( PubMed, DOI )

  53. Kenji Oku, Hiroyuki Nakamura, Michihiro Kono, Kazumasa Ohmura, Masaru Kato, Toshiyuki Bohgaki, Tetsuya Horita, Shinsuke Yasuda, Olga Amengual, Tatsuya Atsumi. Complement and thrombosis in the antiphospholipid syndrome AUTOIMMUNITY REVIEWS. 2016.10; 15 (10): 1001-1004. ( PubMed, DOI )

  54. Kenji Oku, Olga Amengual, Masaru Kato, Toshiyuki Bohgaki, Tetsuya Horita, Shinsuke Yasuda, Naoya Sakamoto, Masahiro Ieko, Gary L. Norman, Tatsuya Atsumi. Significance of fully automated tests for the diagnosis of antiphospholipid syndrome THROMBOSIS RESEARCH. 2016.10; 146 1-6. ( PubMed, DOI )

  55. Ryo Hisada, Masaru Kato, Hisako Nakagawa, Eri Sugawara, Masatoshi Kanda, Kazumasa Ohmura, Ikuma Nakagawa, Kenji Oku, Toshiyuki Bohgaki, Olga Amengual, Tetsuya Horita, Shinsuke Yasuda, Tatsuya Atsumi. Deviation of T and B Cell Subset and Its Association with Single Nucleotide Polymorphisms in Patients with Antiphospholipid Syndrome ARTHRITIS & RHEUMATOLOGY. 2016.10; 68

  56. Kenji Oku, Uhei Shibata, Joana Batuca, Olga Amengual, Michihiro Kono, Hiroyuki Nakamura, Ryo Hisada, Kazumasa Ohmura, Masaru Kato, Toshiyuki Bohgaki, Shinsuke Yasuda, Jose Delgado Alves, Tatsuya Atsumi. Autoantibodies Against High Density Lipoprotein-Associated Proteins Are Related to Elevated Oxidized Low Density Lipoprotein Levels in Antiphospholipid Syndrome ARTHRITIS & RHEUMATOLOGY. 2016.10; 68

  57. Kenji Oku, Olga Amengual, Kazumasa Ohmura, Masaru Kato, Toshiyuki Bohgaki, Tetsuya Horita, Shinsuke Yasuda, Eriko Morishita, Masahiro Ieko, Tatsuya Atsumi. A Practical Application of Antiphospholipid Antibodies Profiles in the Diagnosis and Managements of Antiphospholipid Syndrome: The Modified Antiphospholipid Score ARTHRITIS & RHEUMATOLOGY. 2016.10; 68

  58. Simone Mader, Yoshiyuki Arinuma, Venkatesh Jeganathan, Yuichiro Fujieda, Irena Dujmovi, Jelen Drulovic, Yuko Sakuma, Shinsuke Yasuda, Joel Stern, Cynthia Aranow, Meggan Mackay, Tatsuya Atsumi, Shunsei Hirohata, Betty Diamond. Clinical Utility of Anti-Aquaporin 4 Antibody Measurement in Patients with Neuropsychiatric Systemic Lupus Erythematosus with Neuromyelitis Optica Spectrum Disorder Manifestations ARTHRITIS & RHEUMATOLOGY. 2016.10; 68

  59. Hiroyuki Nakamura, Kenji Oku, Ryo Hisada, Kazumasa Ohmura, Masaru Kato, Toshiyuki Bohgaki, Olga Amengual, Tetsuya Horita, Shinsuke Yasuda, Tatsuya Atsumi. Complement Activation in Antiphospholipid Syndrome Due to the Multi-Activated Pathways of the Complement System ARTHRITIS & RHEUMATOLOGY. 2016.10; 68

  60. Shinsuke Yasuda, Kazumasa Ohmura, Hiroshi Kanazawa, Takashi Kurita, Yujiro Kon, Tomonori Ishii, Satoshi Jodo, Kazuhide Tanimura, Michio Minami, Tomomasa Izumiyama, Takumi Matsumoto, Yoshiharu Amasaki, Yoko Suzuki, Hideki Kasahara, Naofumi Yamauchi, Akito Tsutsumi, Hiromitsu Takemori, Takao Koike, Tatsuya Atsumi. Maintenance Treatment Using Abatacept with Dose Reduction after Achievement of Low Disease Activity in Patients with Rheumatoid Arthritis (MATADOR) - a Prospective, Multicentered, Single Arm Clinical Trial ARTHRITIS & RHEUMATOLOGY. 2016.10; 68

  61. Atsushi Noguchi, Shinsuke Yasuda, Ryo Hisada, Kazumasa Ohmura, Sanae Shimamura, Yuka Shimizu, Masaru Kato, Kenji Oku, Toshiyuki Bohgaki, Olga Amengual, Tetsuya Horita, Miho Suzuki, Yoshihiro Matsumoto, Tatsuya Atsumi. Anti-CCP Antibody Titers Decrease with Altered B-Cell Subpopulation in RA Patients Treated with Tocilizumab ARTHRITIS & RHEUMATOLOGY. 2016.10; 68

  62. Kazumasa Ohmura, Masaru Kato, Toshiyuki Watanabe, Ryo Hisada, Masatoshi Kanda, Sanae Shimamura, Ikuma Nakagawa, Yuka Shimizu, Kenji Oku, Toshiyuki Bohgaki, Olga Amengual, Tetsuya Horita, Shinsuke Yasuda, Tatsuya Atsumi. Preventive Effect of Combined Treatment with Bisphosphonate and Vitamin D on Atherosclerosis in Patients with Systemic Lupus Erythematosus ARTHRITIS & RHEUMATOLOGY. 2016.10; 68

  63. Masaru Kato, Caroline Ospelt, Christoph Kolling, Tomohiro Shimizu, Michihito Kono, Shinsuke Yasuda, Beat A. Michel, Renate E. Gay, Steffen Gay, Kerstin Klein, Tatsuya Atsumi. AAA-ATPase p97 suppresses apoptotic and autophagy-associated cell death in rheumatoid arthritis synovial fibroblasts ONCOTARGET. 2016.09; 7 (39): 64221-64232. ( PubMed, DOI )

  64. Yuka Shimizu, Shinsuke Yasuda, Yuki Kako, Shin Nakagawa, Masatoshi Kanda, Ryo Hisada, Kazumasa Ohmura, Sanae Shimamura, Haruki Shida, Yuichiro Fujieda, Masaru Kato, Kenji Oku, Toshiyuki Bohgaki, Tetsuya Horita, Ichiro Kusumi, Tatsuya Atsumi. Post-steroid neuropsychiatric manifestations are significantly more frequent in SLE compared with other systemic autoimmune diseases and predict better prognosis compared with de novo neuropsychiatric SLE AUTOIMMUNITY REVIEWS. 2016.08; 15 (8): 786-794. ( PubMed, DOI )

  65. Kenji Oku, Olga Amengual, Ryo Hisada, Kazumasa Ohmura, Ikuma Nakagawa, Toshiyuki Watanabe, Toshiyuki Bohgaki, Tetsuya Horita, Shinsuke Yasuda, Tatsuya Atsumi. Autoantibodies against a complement component 1 q subcomponent contribute to complement activation and recurrent thrombosis/pregnancy morbidity in anti-phospholipid syndrome RHEUMATOLOGY. 2016.08; 55 (8): 1403-1411. ( PubMed, DOI )

  66. T. Bohgaki, S. Yasuda, M. Kato, K. Oku, O. Amengual, T. Horita, T. Atsumi. INDUCTION OF TYPE-I INTERFERON MRNA IN HUMAN CD14+CELLS TREATED WITH NEUTROPHIL EXTRACELLULAR TRAPS CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2016.07; 34 (4): S42.

  67. Yuichiro Fujieda, Olga Amengual, Masaki Matsumoto, Kimiko Kuroki, Hidehisa Takahashi, Michihito Kono, Takashi Kurita, Kotaro Otomo, Masaru Kato, Kenji Oku, Toshiyuki Bohgaki, Tetsuya Horita, Shinsuke Yasuda, Katsumi Maenaka, Shigetsugu Hatakeyama, Keiichi I. Nakayama, Tatsuya Atsumi. Ribophorin II is involved in the tissue factor expression mediated by phosphatidylserine-dependent antiprothrombin antibody on monocytes RHEUMATOLOGY. 2016.06; 55 (6): 1117-1126. ( PubMed, DOI )

  68. R. Hisada, M. Kato, E. Sugawara, K. Ohmura, I. Nakagawa, K. Oku, T. Bohgaki, O. Amengual, T. Horita, S. Yasuda, T. Atsumi. THROMBOCYTOPENIA IN PATIENTS WITH ANTIPHOSPHOLIPID ANTIBODIES: A PARADOXICAL THROMBOTIC RISK FACTOR ANNALS OF THE RHEUMATIC DISEASES. 2016.06; 75 315. ( DOI )

  69. Tatsuya Atsumi, Kazuhiko Yamamoto, Tsutomu Takeuchi, Hisashi Yamanaka, Naoki Ishiguro, Yoshiya Tanaka, Katsumi Eguchi, Akira Watanabe, Hideki Origasa, Shinsuke Yasuda, Yuji Yamanishi, Yasuhiko Kita, Tsukasa Matsubara, Masahiro Iwamoto, Toshiharu Shoji, Toshiyuki Okada, Desiree van der Heijde, Nobuyuki Miyasaka, Takao Koike. The first double-blind, randomised, parallel-group certolizumab pegol study in methotrexate-naive early rheumatoid arthritis patients with poor prognostic factors, C-OPERA, shows inhibition of radiographic progression ANNALS OF THE RHEUMATIC DISEASES. 2016.01; 75 (1): 75-83. ( PubMed, DOI )

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  71. Kenji Oku, Olga Amengual, Hiroyuki Nakamura, Ryo Hisada, Kazumasa Oomura, Masaru Mato, Toshiyuki Bohgaki, Tetsuya Horita, Shinsuke Yasuda, Tatsuya Atsumi. Markers of thrombotic events in autoimmune diseases: Comparison of Antiphospholipid Score (aPL-S) and Global Anti-phospholipid Syndrome Score (GAPSS) JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2015.11; 112 129-130. ( DOI )

  72. Kenji Oku, Yusaku Kanetsuka, Olga Amengual, Hiroyuki Nakamura, Kazumasa Oomura, Toshiyuki Bohgaki, Tetsuya Horita, Shinsuke Yasuda, Bas Delaat, Tatsuya Atsumi. Procoagulant Property of a Novel Patient-Derived Autoimmune IgG Type Monoclonal Anticardiolipin Antibody That Binds to Beta 2 Glycoprotein Domain I but Not to Total Beta 2 Glycoprotein I Molecule ARTHRITIS & RHEUMATOLOGY. 2015.10; 67

  73. Toshiyuki Watanabe, Kenji Oku, Olga Amengual, Ryo Hisada, Kazumasa Ohmura, Haruki Shida, Yuka Shimizu, Masaru Kato, Toshiyuki Bohgaki, Tetsuya Horita, Shinsuke Yasuda, Akihiro Ishizu, Hisashi Arase, Tatsuya Atsumi. Reduction of HLA Class II Expression and Beta-2-Glycoprotein I Presentation By Fluvastatin in Vitro and in Vivo: Possible Mechanism of Statin-Induced-Deprocoagulation in the Antiphospholipid Syndrome ARTHRITIS & RHEUMATOLOGY. 2015.10; 67

  74. Masaru Kato, Kerstin Klein, Caroline Ospelt, Christoph Kolling, Michihito Kono, Shinsuke Yasuda, Renate E. Gay, Steffen Gay, Tatsuya Atsumi. AAA-Atpase p97-HDAC6 Controlled Poly-Ubiquitin Turnover Regulates Apoptotic and Autophagy-Associated Cell Death in Arthritis ARTHRITIS & RHEUMATOLOGY. 2015.10; 67

  75. Takehiro Yamada, Nobuhisa Ishiguro, Kenji Oku, Issei Higuchi, Ikuma Nakagawa, Atsushi Noguchi, Shinsuke Yasuda, Tatsuya Fukumoto, Sumio Iwasaki, Kouji Akizawa, Ayako Furugen, Hiroaki Yamaguchi, Ken Iseki. Successful Colistin Treatment of Multidrug-Resistant Pseudomonas aeruginosa Infection Using a Rapid Method for Determination of Colistin in Plasma: Usefulness of Therapeutic Drug Monitoring BIOLOGICAL & PHARMACEUTICAL BULLETIN. 2015.09; 38 (9): 1430-1433. ( PubMed, DOI )

  76. Michihito Kono, Shinsuke Yasuda, Toshiyuki Watanabe, Tatsuya Atsumi. Projectile haemorrhage of a brachial artery in a patient with clinically amyopathic dermatomyositis RHEUMATOLOGY. 2015.08; 54 (8): 1530-1531. ( PubMed, DOI )

  77. Takashi Kurita, Shinsuke Yasuda, Koji Oba, Toshio Odani, Michihito Kono, Kotaro Otomo, Yuichiro Fujieda, Kenji Oku, Toshiyuki Bohgaki, Olga Amengual, Tetsuya Horita, Tatsuya Atsumi. The efficacy of tacrolimus in patients with interstitial lung diseases complicated with polymyositis or dermatomyositis. Rheumatology (Oxford, England). 2015.08; 54 (8): 1536. ( PubMed, DOI )

  78. Shinsuke Yasuda, Takashi Kurita, Tetsuya Horita, Tatsuya Atsumi. Comment on: The efficacy of tacrolimus in patients with interstitial lung diseases complicated with polymyositis or dermatomyositis: reply RHEUMATOLOGY. 2015.06; 54 (6): 1129. ( PubMed, DOI )

  79. K. Oku, O. Amengual, T. Bohgaki, T. Horita, S. Yasuda, T. Atsumi. An independent validation of the Global Anti-Phospholipid Syndrome Score in a Japanese cohort of patients with autoimmune diseases LUPUS. 2015.06; 24 (7): 774-775. ( PubMed, DOI )

  80. M. Kato, K. Klein, C. Ospelt, C. Kolling, M. Kono, S. Yasuda, R. E. Gay, S. Gay, T. Atsumi. AAA-ATPASE P97 REGULATES APOPTOTIC AND AUTOPHAGY-ASSOCIATED CELL DEATH IN ARTHRITIS ANNALS OF THE RHEUMATIC DISEASES. 2015.06; 74 207-208. ( DOI )

  81. A. Noguchi, S. Yasuda, M. Kono, M. Kato, K. Oku, T. Bohgaki, O. Amengual, T. Horita, T. Sato, I. Tsujino, M. Nishimura, T. Atsumi. CARDIAC MAGNETIC RESONANCE IMAGING DETECTS DISEASE-SPECIFIC BIVENTRICULAR INVOLVEMENT IN PATIENTS WITH SYSTEMIC SCLEROSIS-ASSOCIATED PULMONARY ARTERIAL HYPERTENSION ANNALS OF THE RHEUMATIC DISEASES. 2015.06; 74 1124. ( DOI )

  82. K. Oku, O. Amengual, R. Hisada, K. Oomura, Nakagawa, I, T. Watanabe, T. Bohgaki, T. Horita, S. Yasuda, T. Atsumi. Predictive markers for thrombotic events in autoimmune diseases: comparison of antiphospholipid score (APL-S) and global anti-phospholipid syndrome score (GAPSS) JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2015.06; 13 775.

  83. S. Yasuda, Y. Shimizu, M. Kono, S. Shimamura, A. Noguchi, H. Shida, T. Watanabe, M. Kato, K. Oku, T. Bohgaki, O. Amengual, T. Horita, T. Atsumi. Myxovirus resistance protein 1 (Mx1) levels are elevated in T cells of the patients with SLE and serum Mx1 is a marker of Neuropsychiatric SLE CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2015.05; 33 (3): S20.

  84. Tanimura K, Jin H, Suenaga T, Morikami S, Arase N, Kishida K, Hirayasu K, Kohyama M, Ebina Y, Yasuda S, Horita T, Takasugi K, Ohmura K, Yamamoto K, Katayama I, Sasazuki T, Lanier LL, Atsumi T, Yamada H, Arase H. β2-glycoprotein I / HLA class II complexes are novel autoantigens in antiphospholipid syndrome. Blood. 2015.04; 125 (18): 2835-2844. ( PubMed, DOI )

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  86. Ryoko Sakai, Soo-Kyung Cho, Toshihiro Nanki, Kaori Watanabe, Hayato Yamazaki, Michi Tanaka, Ryuji Koike, Yoshiya Tanaka, Kazuyoshi Saito, Shintaro Hirata, Koichi Amano, Hayato Nagasawa, Takayuki Sumida, Taichi Hayashi, Takahiko Sugihara, Hiroaki Dobashi, Shinsuke Yasuda, Tetsuji Sawada, Kazuhiko Ezawa, Atsuhisa Ueda, Takao Fujii, Kiyoshi Migita, Nobuyuki Miyasaka, Masayoshi Harigai. Head-to-head comparison of the safety of tocilizumab and tumor necrosis factor inhibitors in rheumatoid arthritis patients (RA) in clinical practice: results from the registry of Japanese RA patients on biologics for long-term safety (REAL) registry ARTHRITIS RESEARCH & THERAPY. 2015.03; 17 74. ( PubMed, DOI )

  87. Michihito Kono, Shinsuke Yasuda, Richard L. Stevens, Hideyuki Koide, Takashi Kurita, Yuka Shimizu, Yusaku Kanetsuka, Kenji Oku, Toshiyuki Bohgaki, Olga Amengual, Tetsuya Horita, Tomohiro Shimizu, Tokifumi Majima, Takao Koike, Tatsuya Atsumi. Ras Guanine Nucleotide-Releasing Protein 4 Is Aberrantly Expressed in the Fibroblast-like Synoviocytes of Patients With Rheumatoid Arthritis and Controls Their Proliferation ARTHRITIS & RHEUMATOLOGY. 2015.02; 67 (2): 396-407. ( PubMed, DOI )

  88. Kanako Watanabe, Shinsuke Yasuda, Atsushi Noguchi, Tetsuya Horita, Tatsuya Atsumi. Clinical Images: Coronary and mesenteric involvement in polyarteritis nodosa ARTHRITIS & RHEUMATOLOGY. 2015.02; 67 (2): 583. ( PubMed, DOI )

  89. Kurita T, Yasuda S, Oba K, Odani T, Kono M, Otomo K, Fujieda Y, Oku K, Bohgaki T, Amengual O, Horita T, Atsumi T. The efficacy of tacrolimus in patients with interstitial lung diseases complicated with polymyositis or dermatomyositis. Rheumatology (Oxford, England). 2015.01; 54 (1): 39-44. ( PubMed, DOI )

  90. Hiroshi Kataoka, Shinsuke Yasuda, Shinji Fukaya, Kenji Oku, Tetsuya Horita, Tatsuya Atsumi, Takao Koike. Decreased expression of Runx1 and lowered proportion of Foxp3(+)CD25(+)CD4(+) regulatory T cells in systemic sclerosis MODERN RHEUMATOLOGY. 2015.01; 25 (1): 90-95. ( PubMed, DOI )

  91. T. Kurita, S. Yasuda, O. Amengual, T. Atsumi. The efficacy of calcineurin inhibitors for the treatment of interstitial lung disease associated with polymyositis/dermatomyositis LUPUS. 2015.01; 24 (1): 3-9. ( PubMed, DOI )

  92. Shinsuke Yasuda, Tatsuya Atsumi, Sanae Shimamura, Kota Ono, Keiju Hiromura, Kenei Sada, Masaaki Mori, Syuji Takei, Yasushi Kawaguchi, Naoto Tamura, Yoshinari Takasaki. Surveillance for the use of mycophenolate mofetil for adult patients with lupus nephritis in Japan MODERN RHEUMATOLOGY. 2015; 25 (6): 854-857. ( DOI )

  93. Ryoki Hara, Hirotaka Miyazawa, Kenichi Nishimura, Takahiro Momoi, Tomo Nozawa, Masako Kikuchi, Nodoka Sakurai, Toshitaka Kizawa, Sanae Shimamura, Shinsuke Yasuda, Keiju Hiromura, Ken-ei Sada, Yasushi Kawaguchi, Naoto Tamura, Syuji Takei, Yoshinari Takasaki, Tatsuya Atsumi, Masaaki Mori. A national survey on current use of mycophenolate mofetil for childhood-onset systemic lupus erythematosus in Japan MODERN RHEUMATOLOGY. 2015; 25 (6): 858-864. ( PubMed, DOI )

  94. Yuka Shimizu, Shinsuke Yasuda, Takashi Kurita, Sanae Shimamura, Ikuma Nakagawa, Atsushi Noguchi, Haruki Shida, Toshiyuki Watanabe, Michihito Kono, Kenji Oku, Toshiyuki Bohgaki, Olga Amengual, Tetsuya Horita, Tatsuya Atsumi. Upregulation of Myxovirus Resistance Protein 1 in Patients with Neuropsychiatric Systemic Lupus Erythematosus ARTHRITIS & RHEUMATOLOGY. 2014.10; 66 S718-S719. ( DOI )

  95. M. Kono, S. Yasuda, M. Kato, Y. Kanetsuka, T. Kurita, Y. Fujieda, K. Otomo, T. Horita, K. Oba, M. Kondo, M. Mukai, M. Yanai, Y. Fukasawa, T. Atsumi. Long-term outcome in Japanese patients with lupus nephritis LUPUS. 2014.10; 23 (11): 1124-1132. ( PubMed, DOI )

  96. Ikuma Nakagawa, Kenji Oku, Olga Amengual, Ryo Hisada, Eri Sugawara, Kazumasa Ohmura, Tomoko Fukui, Sanae Shimamura, Haruki Shida, Toshiyuki Watanabe, Yuka Shimizu, Michihito Kono, Takashi Kurita, Toshiyuki Bohgaki, Tetsuya Horita, Shinsuke Yasuda, Tatsuya Atsumi. Thrombocytopenia in Primary Antiphospholipid Syndrome Is Related to Arterial Thrombosis ARTHRITIS & RHEUMATOLOGY. 2014.10; 66 S1.

  97. Takashi Kurita, Shinsuke Yasuda, Vaishali Moulton, Yuka Shimizu, Michihito Kono, Hideyuki Koide, Kenji Oku, Toshiyuki Bohgaki, Olga Amengual, Tetsuya Horita, George C. Tsokos, Tatsuya Atsumi. Decreased Levels of SRSF1 (Serin/Arginine-Rich Splicing Factor1) Induced Lower Levels of RasGRP1 in T Cells from Patients with Systemic Lupus Erythematosus. ARTHRITIS & RHEUMATOLOGY. 2014.10; 66 S1171.

  98. Kenji Oku, Olga Amengual, Ryo Hisada, Kazumasa Oomura, Ikuma Nakagawa, Toshiyuki Watanabe, Toshiyuki Bohgaki, Tetsuya Horita, Shinsuke Yasuda, Tatsuya Atsumi. Markers of Thrombotic Events in Autoimmune Diseases: Comparison of Antiphospholipid Score (aPL-S) and Global Anti-Phospholipid Syndrome Score (GAPSS). ARTHRITIS & RHEUMATOLOGY. 2014.10; 66 S1251-S1252.

  99. Michihito Kono, Shinsuke Yasuda, Kazumasa Ohmura, Tomoko Fukui, Sanae Shimamura, Ikuma Nakagawa, Atsushi Noguchi, Haruki Shida, Toshiyuki Watanabe, Yuka Shimizu, Takashi Kurita, Kenji Oku, Toshiyuki Bohgaki, Olga Amengual, Tetsuya Horita, Keita Sakamoto, Tamotsu Kamishima, Tatsuya Atsumi. Efficacy of Tocilizumab in Patients with Rheumatoid Arthritis: Sequential Evaluation Using Whole-Body Magnetic Resonance Imaging. ARTHRITIS & RHEUMATOLOGY. 2014.10; 66 S518. ( DOI )

  100. Toshiyuki Watanabe, Kenji Oku, Olga Amengual, Eri Sugawara, Ryo Hisada, Kazumasa Ohmura, Tomoko Fukui, Sanae Shimamura, Ikuma Nakagawa, Atsushi Noguchi, Haruki Shida, Michihito Kono, Yuka Shimizu, Takashi Kurita, Toshiyuki Bohgaki, Tetsuya Horita, Shinsuke Yasuda, Tatsuya Atsumi. The Protective Effects of Statins for Thrombosis in Patients with Systemic Lupus Erythematosus Positive for Antiphospholipid Antibodies. ARTHRITIS & RHEUMATOLOGY. 2014.10; 66 S1154-S1155.

  101. Tomoko Fukui, Shinsuke Yasuda, Toshiyuki Watanabe, Kazumasa Ohmura, Sanae Shimamura, Ikuma Nakagawa, Atsushi Noguchi, Haruki Shida, Yuka Shimizu, Michihito Kono, Takashi Kurita, Kenji Oku, Toshiyuki Bohgaki, Olga Amengual, Tetsuya Horita, Tatsuya Atsumi. Antiphospholipid-Associated Nephropathy Is a Risk for Developing Arterial Thromboses in Patients with Systemic Lupus Erythematosus ARTHRITIS & RHEUMATOLOGY. 2014.10; 66 S3.

  102. Masaru Kato, Kerstin Klein, Caroline Ospelt, Christoph Kolling, Michihito Kono, Shinsuke Yasuda, Renate E. Gay, Steffen Gay, Tatsuya Atsumi. AAA-Atpase p97 Regulates Autophagy-Associated Cell Death in Arthritis ARTHRITIS & RHEUMATOLOGY. 2014.10; 66 S195.

  103. Olga Amengual, Tetsuya Horita, Walter Binder, Gary L. Norman, Zakera Shums, Masaru Kato, Kotaro Otomo, Yuichiro Fujieda, Kenji Oku, Toshiyuki Bohgaki, Shinsuke Yasuda, Tatsuya Atsumi. Comparative analysis of different enzyme immunoassays for assessment of phosphatidylserine-dependent antiprothrombin antibodies RHEUMATOLOGY INTERNATIONAL. 2014.09; 34 (9): 1225-1230. ( PubMed, DOI )

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  115. T. Odani, S. Yasuda, M. Kono, T. Kurita, Y. Fujieda, K. Otomo, Y. Kon, T. Horita, T. Atsumi. EFFECTIVENESS OF AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR INTERSTITIAL LUNG DISEASES IN PATIENTS WITH SYSTEMIC SCLEROSIS ANNALS OF THE RHEUMATIC DISEASES. 2012.06; 71 241.

  116. T. Kurita, S. Yasuda, K. Oba, K. Otomo, H. Shida, T. Watanabe, Y. Kanetsuka, M. Kono, T. Odani, Y. Fujieda, Y. Kon, T. Horita, N. Sato, T. Atsumi. THE EFFICACY OF TACROLIMUS IN PATIENTS WITH INTERSTITIAL LUNG DISEASES COMPLICATED WITH POLYMYOSITIS OR DERMATOMYOSITIS ANNALS OF THE RHEUMATIC DISEASES. 2012.06; 71 233.

  117. Kotaro Otomo, Tatsuya Atsumi, Olga Amengual, Yuichiro Fujieda, Masaru Kato, Kenji Oku, Tetsuya Horita, Shinsuke Yasuda, Takao Koike. Efficacy of the antiphospholipid score for the diagnosis of antiphospholipid syndrome and its predictive value for thrombotic events ARTHRITIS AND RHEUMATISM. 2012.02; 64 (2): 504-512. ( PubMed, DOI )

  118. Kato Masaru, Atsumi Tatsuya, Kurita Takashi, Odani Toshio, Fujieda Yuichiro, Otomo Kotaro, Horita Tetsuya, Yasuda Shinsuke, Koike Takao. Hepatitis B Virus Reactivation by Immunosuppressive Therapy in Patients with Autoimmune Diseases: Risk Analysis in Hepatitis B Surface Antigen-negative Cases JOURNAL OF RHEUMATOLOGY. 2011.10; 38 (10): 2209-2214. ( DOI )

  119. Kato M., Kataoka H., Odani T., Fujieda Y., Otomo K., Oku K., Horita T., Yasuda S., Atsumi T., Ohira H., Tsujino I., Nishimura M., Koike T.. The short-term role of corticosteroid therapy for pulmonary arterial hypertension associated with connective tissue diseases: report of five cases and a literature review LUPUS. 2011.10; 20 (10): 1047-1056. ( DOI )

  120. Sakai Ryoko, Komano Yukiko, Tanaka Michi, Nanki Toshihiro, Koike Ryuji, Nakajima Atsuo, Atsumi Tatsuya, Yasuda Shinsuke, Tanaka Yoshiya, Saito Kazuyoshi, Tohma Shigeto, Fujii Takao, Ihata Atsushi, Tamura Naoto, Kawakami Atsushi, Sugihara Takahiko, Ito Satoshi, Miyasaka Nobuyuki, Harigai Masayoshi. The REAL database reveals no significant risk of serious infection during treatment with a methotrexate dose of more than 8 mg/week in patients with rheumatoid arthritis MODERN RHEUMATOLOGY. 2011.08; 21 (4): 444-448. ( DOI )

  121. K. Otomo, O. Amengual, T. Atsumi, Y. Fujieda, M. Kato, T. Horita, S. Yasuda, W. Binder, T. Koike. Phosphatidylserine-dependent antiprothrombin antibodies (aPS/Pt) is a useful predictive marker of thrombosis in patients with autoimmune diseases JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2011.07; 9 419-420.

  122. Y. Fujieda, T. Atsumi, K. Otomo, M. Kato, K. Oku, O. Amegual, S. Yasuda, T. Horita, T. Koike. Predominant prevalence of stroke in Japanese patients with the antiphospholipid syndrome JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2011.07; 9 514-515.

  123. K. Oku, T. Atsumi, O. Amengual, Y. Fujieda, K. Otomo, M. Kato, S. Furukawa, H. Kitakawa, S. Yasuda, T. Horita, Y. Hori, T. Nishikawa, K. Nihei, M. Ieko, T. Koike. Platelet activation and paradoxical inhibition of ADP induced aggregation by antiphospholipid antibodies in vitro JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2011.07; 9 165.

  124. Fujieda Yuichiro, Kataoka Hiroshi, Odani Toshio, Otomo Kotaro, Kato Masaru, Fukaya Shinji, Oku Kenji, Horita Tetsuya, Yasuda Shinsuke, Atsumi Tatsuya, Koike Takao. Clinical features of reversible posterior leukoencephalopathy syndrome in patients with systemic lupus erythematosus MODERN RHEUMATOLOGY. 2011.06; 21 (3): 276-281. ( DOI )

  125. Bohgaki Miyuki, Matsumoto Masaki, Atsumi Tatsuya, Kondo Takeshi, Yasuda Shinsuke, Horita Tetsuya, Nakayama Keiichi I., Okumura Fumihiko, Hatakeyama Shigetsugu, Koike Takao. Plasma gelsolin facilitates interaction between beta(2) glycoprotein I and alpha(5)beta(1) integrin JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2011.01; 15 (1): 141-151. ( DOI )

  126. Toko Hashimoto, Shinsuke Yasuda, Hideyuki Koide, Hiroshi Kataoka, Tetsuya Horita, Tatsuya Atsumi, Takao Koike. Aberrant splicing of the hRasGRP4 transcript and decreased levels of this signaling protein in the peripheral blood mononuclear cells in a subset of patients with rheumatoid arthritis ARTHRITIS RESEARCH & THERAPY. 2011; 13 (5): R154. ( PubMed, DOI )

  127. Suzuki Eriko, Amengual Olga, Atsumi Tatsuya, Oku Kenji, Hashimoto Toko, Kataoka Hiroshi, Horita Tetsuya, Yasuda Shinsuke, Ieko Masahiro, Fukushima Kazuaki, Koike Takao. Increased Expression of Phospholipid Scramblase 1 in Monocytes from Patients with Systemic Lupus Erythematosus JOURNAL OF RHEUMATOLOGY. 2010.08; 37 (8): 1639-1645. ( DOI )

  128. Matsuura E., Shen L., Matsunami Y., Quan N., Makarova M., Geske F. J., Boisen M., Yasuda S., Kobayashi K., Lopez L. R.. Pathophysiology of beta(2)-glycoprotein I in antiphospholipid syndrome LUPUS. 2010.04; 19 (4): 379-384. ( DOI )

  129. Nakagawa Hisako, Yasuda Shinsuke, Matsuura Eiji, Kobayashi Kazuko, Ieko Masahiro, Kataoka Hiroshi, Horita Tetsuya, Atsumi Tatsuya, Koike Takao. Nicked beta 2-glycoprotein I binds angiostatin 4.5 (plasminogen kringle 1-5) and attenuates its antiangiogenic property BLOOD. 2009.09; 114 (12): 2553-2559. ( DOI )

  130. Horita T., Atsumi T., Yoshida N., Nakagawa H., Kataoka H., Yasuda S., Koike T.. STAT4 single nucleotide polymorphism, rs7574865 G/T, as a risk for antiphospholipid syndrome ANNALS OF THE RHEUMATIC DISEASES. 2009.08; 68 (8): 1366-1367. ( DOI )

  131. Sakai Yoshie, Atsumi Tatsuya, Ieko Masahiro, Amengual Olga, Furukawa Shin, Furusaki Akira, Bohgaki Miyuki, Kataoka Hiroshi, Horita Tetsuya, Yasuda Shinsuke, Koike Takao. The Effects of Phosphatidylserine-Dependent Antiprothrombin Antibody on Thrombin Generation ARTHRITIS AND RHEUMATISM. 2009.08; 60 (8): 2457-2467. ( DOI )

  132. Oku K., Atsumi T., Bohgaki M., Amengual O., Kataoka H., Horita T., Yasuda S., Koike T.. Complement activation in patients with primary antiphospholipid syndrome ANNALS OF THE RHEUMATIC DISEASES. 2009.06; 68 (6): 1030-1035. ( DOI )

  133. Bohgaki Toshiyuki, Atsumi Tatsuya, Bohgaki Miyuki, Furusaki Akira, Kondo Makoto, Sato-Matsumura Kazuko C., Abe Riichiro, Kataoka Hiroshi, Horita Tetsuya, Yasuda Shinsuke, Amasaki Yoshiharu, Nishio Mitsufumi, Sawada Ken-Ichi, Shimizu Hiroshi, Koike Takao. Immunological Reconstitution after Autologous Hematopoietic Stem Cell Transplantation in Patients with Systemic Sclerosis: Relationship Between Clinical Benefits and Intensity of Immunosuppression JOURNAL OF RHEUMATOLOGY. 2009.06; 36 (6): 1240-1248. ( DOI )

  134. Yamada Hideto, Atsumi Tatsuya, Kobashi Gen, Ota Chikako, Kato Emi H., Tsuruga Noriko, Ohta Kaori, Yasuda Shinsuke, Koike Takao, Minakami Hisanori. Antiphospholipid antibodies increase the risk of pregnancy-induced hypertension and adverse pregnancy outcomes JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2009.01; 79 (2): 188-195. ( DOI )

  135. Fukaya S., Yasuda S., Hashimoto T., Oku K., Kataoka H., Horita T., Atsumi T., Koike T.. Clinical features of haemophagocytic syndrome in patients with systemic autoimmune diseases: analysis of 30 cases RHEUMATOLOGY. 2008.11; 47 (11): 1686-1691. ( DOI )

  136. Tetsuya Horita, Nobuya Yoshida, Hisako Nakagawa, Hiroshi Kataoka, Shinsuke Yasuda, Tatsuya Atsumi, Takao Koike. STAT4 polymorphisms are associated with not only systemic lupus erythematosus, but also antiphospholipid syndrome ARTHRITIS AND RHEUMATISM. 2008.09; 58 (9): S175-S176.

  137. Shinsuke Yasuda, Richard L. Stevens, Tomoko Terada, Toko Hashimoto, Hiroshi Kataoka, Tetsuya Horita, Tatsuya Atsumi, Takao Koike. Alternative splicing of RasGRP1 in lupus patients: Frequency, clinical features and cytokine production ARTHRITIS AND RHEUMATISM. 2008.09; 58 (9): S817-S818.

  138. Kenji Oku, Tatsuya Atsumi, Olga Amengual, Eriko Miyamoto, Kotaro Otomo, Masaru Kato, Hiroshi Kataoka, Tetsuya Horita, Shinsuke Yasuda, Takao Koike. The phosphatidylserine-dependent monoclonal antiprothrombin antibody with lupus anticoagulant activity induces tissue factor and adhesion molecules expression on endothelial cells: Possible implication of p38 mitogen-activate protein kinase (MAPK) pathway ARTHRITIS AND RHEUMATISM. 2008.09; 58 (9): S404-S405.

  139. Kataoka Hiroshi, Atsumi Tatsuya, Hashimoto Toko, Horita Tetsuya, Yasuda Shinsuke, Koike Takao. Polymyalgia rheumatica as the manifestation of unclassified aortitis MODERN RHEUMATOLOGY. 2008.02; 18 (1): 105-108. ( DOI )

  140. Y. Kon, T. Atsumi, H. Hagiwara, A. Furusaki, H. Kataoka, T. Horita, S. Yasuda, O. Amengual, K. Takao. Thrombotic microangiopathy in patients with phosphatidylserine dependent antiprothrombin antibodies and antiphospholipid syndrome CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2008.01; 26 (1): 129-132. ( PubMed )

  141. Kon Y., Atsumi T., Hagiwara H., Furusaki A., Kataoka H., Horita T., Yasuda S., Amengual O., Takao K.. Thrombotic microangiopathy in patients with phosphatidylserine dependent antiprothrombin antibodies and antiphospholipid syndrome CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2008; 26 (1): 129-132.

  142. Yasuda Shinsuke, Stevens Richard L., Terada Tomoko, Takeda Masumi, Hashimoto Toko, Fukae Jun, Horita Tetsuya, Kataoka Hiroshi, Atsumi Tatsuya, Koike Takao. Defective expression of ras guanyl nucleotide-releasing protein 1 in a subset of patients with systemic lupus erythematosus JOURNAL OF IMMUNOLOGY. 2007.10; 179 (7): 4890-4900.

  143. Shinsuke Yasuda, Richard L. Stevens, Tomoko Terada, Masumi Takeda, Toko Hashimoto, Jun Fukae, Tetsuya Horita, Hiroshi Kataoka, Tatsuya Atsumi, Takao Koike. Defective expression of ras guanyl nucleotide-releasing protein 1 in a subset of patients with systemic lupus erythematosus JOURNAL OF IMMUNOLOGY. 2007.10; 179 (7): 4890-4900. ( PubMed )

  144. Amengual Olga, Atsumi Tatsuya, Komano Yukiko, Kataoka Hiroshi, Horita Tetsuya, Yasuda Shinsuke, Koike Takao. A polymorphism in human platelet antigen 6b and risk of thrombocytopenia in patients with systemic lupus erythematosus ARTHRITIS AND RHEUMATISM. 2007.08; 56 (8): 2803-2805. ( DOI )

  145. T. Hashimoto, S. Yasuda, H. Kataoka, T. Horita, T. Atsumi, R. L. Stevens, T. Koike. Altered expression of RASGRP4 in a subset of patients with rheumatoid arthritis ANNALS OF THE RHEUMATIC DISEASES. 2007.07; 66 289.

  146. H. Kataoka, Y. Kawase, T. Horita, S. Yasuda, T. Atsumi, T. Koike. Impaired homeostasis of regulatory T cells in patients with systemic lupus erythematosus ANNALS OF THE RHEUMATIC DISEASES. 2007.07; 66 309.

  147. T. Bohgaki, T. Atsumi, M. Bohgaki, A. Furusaki, M. Kondo, M. Nishio, H. Kataoka, T. Horita, S. Yasuda, Y. Amasaki, T. Koike. Clinical effect of autologous hematopoietic stem cell transplantation against interstitial pneumonia in patients with systemic sclerosis ANNALS OF THE RHEUMATIC DISEASES. 2007.07; 66 202.

  148. T. Horita, H. Nakagawa, Y. Sakai, H. Kataoka, S. Yasuda, T. Atsumi, T. Koike. CD45 exon 6 A138G polymorphism is associated with antiphospholipid syndrome CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2007.03; 25 (2): 137.

  149. K. Oku, T. Atsumi, O. Amengual, H. Kataoka, T. Horita, S. Yasuda, T. Koike. Phosphatidylserine dependent antiprothrombin antibody induces p38 mitogen-activated protein kinase (MAPK) phosphorylation leading to tissue factor expression CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2007.03; 25 (2): 160.

  150. Horita T., Ichikawa K., Kataoka H., Yasuda S., Atsumi T., Koike T.. Human monoclonal antibodies against the complex of phosphatidylserine and prothrombin from patients with the antiphospholipid antibodies LUPUS. 2007; 16 (7): 509-516. ( DOI )

  151. T. Horita, K. Ichikawa, H. Kataoka, S. Yasuda, T. Atsumi, T. Koike. Human monoclonal antibodies against the complex of phosphatidylserine and prothrombin from patients with the antiphospholipid antibodies LUPUS. 2007; 16 (7): 509-516. ( PubMed, DOI )

  152. Furukawa S., Yasuda S., Amengual O., Horita T., Atsumi T., Koike T.. Protective effect of pravastatin on vascular endothelium in patients with systemic sclerosis: a pilot study ANNALS OF THE RHEUMATIC DISEASES. 2006.08; 65 (8): 1118-1120. ( DOI )

  153. A. Kusunoki, S. Yasuda, T. Horita, T. Atsumi, T. Koike. R131 allele of Fcg receptor IIA polymorphism is a risk factor in patients with systemic lupus erythematosus ANNALS OF THE RHEUMATIC DISEASES. 2006.07; 65 203.

  154. Kasahara H, Matsuura E, Kaihara K, Yamamoto D, Kobayashi K, Inagaki J, Ichikawa K, Tsutsumi A, Yasuda S, Atsumi T, Yasuda T, Koike T. Antigenic structures recognized by anti-beta 2-glycoprotein I auto-antibodies INTERNATIONAL IMMUNOLOGY. 2005.12; 17 (12): 1533-1542. ( DOI )

  155. Fukae J, Amasaki Y, Yamashita Y, Bohgaki T, Yasuda S, Jodo S, Atsumi T, Koike T. Butyrate suppresses tumor necrosis factor alpha production by regulating specific messenger RNA degradation mediated through a cis-acting AU-rich element ARTHRITIS AND RHEUMATISM. 2005.09; 52 (9): 2697-2707. ( DOI )

  156. A Tatsuya, O Amengual, Y Sakai, T Horita, S Yasuda, T Koike. Induction of tissue factor by monoclonal phosphatidylserine dependent antiprothrombin antibody. ARTHRITIS AND RHEUMATISM. 2005.09; 52 (9): S599-S600.

  157. K Oku, T Atsumi, M Bohgaki, Y Sakai, T Horita, S Yasuda, T Koike. High prevalence of hypocomplementemia in patients with primary antiphospholipid syndrome. ARTHRITIS AND RHEUMATISM. 2005.09; 52 (9): S596.

  158. Y Sakai, T Atsumi, O Amengual, S Yasuda, M Ieko, T Koike. Effects of phosphatidylserine dependent antiprothrombin antibody on thrombin generation in vitro. ARTHRITIS AND RHEUMATISM. 2005.09; 52 (9): S599.

  159. A Olga, A Tatsuya, S Yoshie, T Horita, S Yasuda, T Koike. Induction of lipid scramblase mRNA by antiphosphospholip antibodies: A new possible pathogenic mechanism of thrombosis in patients with antiphosphopholipid syndrome. ARTHRITIS AND RHEUMATISM. 2005.09; 52 (9): S252-S253.

  160. Atsumi T, Amengual O, Yasuda S, Matsuura E, Koike T. Research around beta 2-glycoprotein I: A major target for antiphospholipid antibodies AUTOIMMUNITY. 2005.08; 38 (5): 377-381. ( DOI )

  161. Abonia JP, Friend DS, Austen WG, Moore FD, Carroll MC, Chan R, Afnan J, Humbles A, Gerard C, Knight P, Kanaoka Y, Yasuda S, Morokawa N, Austen KF, Stevens RL, Gurish MF. Mast cell protease 5 mediates ischemia-reperfusion injury of mouse skeletal muscle JOURNAL OF IMMUNOLOGY. 2005.06; 174 (11): 7285-7291.

  162. JP Abonia, DS Friend, WG Austen, FD Moore, MC Carroll, R Chan, J Afnan, A Humbles, C Gerard, P Knight, Y Kanaoka, S Yasuda, N Morokawa, KF Austen, RL Stevens, MF Gurish. Mast cell protease 5 mediates ischemia-reperfusion injury of mouse skeletal muscle JOURNAL OF IMMUNOLOGY. 2005.06; 174 (11): 7285-7291. ( PubMed )

  163. Yasuda S, Morokawa N, Wong GW, Rossi A, Madhusudhan MS, Sali A, Askew YS, Adachi R, Silverman GA, Krilis SA, Stevens RL. Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22 BLOOD. 2005.05; 105 (10): 3893-3901. ( DOI )

  164. Yasuda S, Atsumi T, Matsuura E, Kaihara K, Yamamoto D, Ichikawa K, Koike T. Significance of valine/leucine(247) polymorphism of beta(2)-glycoprotein I in antiphospholipid syndrome - Increased reactivity of anti-beta(2)-glycoprotein I autoantibodies to the valine(247) gamma(2)-glycoprotein I variant ARTHRITIS AND RHEUMATISM. 2005.01; 52 (1): 212-218. ( DOI )

  165. Yasuda S, Bohgaki M, Atsumi T, Koike T. Pathogenesis of antiphospholipid antibodies: impairment of fibrinolysis and monocyte activation via the p38 mitogen-activated protein kinase pathway IMMUNOBIOLOGY. 2005; 210 (10): 775-780. ( DOI )

  166. Bohgaki M, Atsumi T, Yamashita Y, Yasuda S, Sakai Y, Furusaki A, Bohgaki T, Amengual O, Amasaki Y, Koike T. The p38 mitogen-activated protein kinase (MAPK) pathway mediates induction of the tissue factor gene in monocytes stimulated with human monoclonal anti-beta(2)Glycoprotein I antibodies INTERNATIONAL IMMUNOLOGY. 2004.11; 16 (11): 1633-1641. ( DOI )

  167. T Bohgaki, Y Amasaki, N Nishimura, Y Yamashita, M Nishio, K Sawada, S Yasuda, T Atsumi, T Koike. Specific upregulation of tumor necrosis factor alpha (TNFa) converting enzyme(TACE) expression in patients with systemic sclerosis ARTHRITIS AND RHEUMATISM. 2004.09; 50 (9): S639.

  168. O Amengual, T Atsumi, S Yasuda, Y Amasaki, T Koike. Diagnostic value of matrix metalloproteinase 3 (MMP-3) in serum of patients with arthralgias ARTHRITIS AND RHEUMATISM. 2004.09; 50 (9): S161-S162.

  169. S Furukawa, S Yasuda, Y Sakai, M Kondo, Y Kon, O Amengual, Y Amasaki, T Atsumi, T Koike. Protective effect of pravastatin on vascular endothelium in patients with systemic sclerosis: A pilot study ARTHRITIS AND RHEUMATISM. 2004.09; 50 (9): S693.

  170. S Yasuda, T Atsumi, M Ieko, E Matsuura, Y Amasaki, T Koike. Nicked beta2-glycoprotein I binds to plasminogen and plays a role in extrinsic fibrinolysis via negative feedback mechanism ARTHRITIS AND RHEUMATISM. 2004.09; 50 (9): S640.

  171. T Atsumi, M Ieko, Y Sakai, Y Kon, S Furukawa, O Amengual, S Yasuda, Y Amasaki, T Koike. Phosphatidylserine dependent antiprothrombin antibodies provide one of the best diagnostic values for the laboratory evaluation in patients with antiphospholipid syndrome. ARTHRITIS AND RHEUMATISM. 2004.09; 50 (9): S68-S69.

  172. Yasuda S, Atsumi T, Ieko M, Matsuura E, Kobayashi K, Inagaki J, Kato H, Tanaka H, Yamakado M, Akino M, Saitou H, Amasaki Y, Jodo S, Amengual O, Koike T. Nicked beta(2)-glycoprotein I: a marker of cerebral infarct and a novel role in the negative feedback pathway of extrinsic fibrinolysis BLOOD. 2004.05; 103 (10): 3766-3772. ( DOI )

  173. Shinsuke Yasuda, Nobutaka Ogura, Tetsuya Horita, Izumi Yasuda, Takaya Hioka, Nobuo Kondo, Atsushi Fujisaku. Abacterial prostatitis and primary biliary cirrhosis with Sjögren's syndrome Modern Rheumatology. 2004.03; 14 (1): 70-72. ( PubMed, DOI )

  174. S Yasuda, GW Wong, A Rossi, MS Madhusudhan, N Morokawa, A Sali, SA Krilis, RL Stevens. Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22 FASEB JOURNAL. 2004.03; 18 (5): A793.

  175. Wong GW, Yasuda S, Morokawa N, Li LX, Stevens RL. Mouse chromosome 17A3.3 contains 13 genes that encode functional tryptic-like serine proteases with distinct tissue and cell expression patterns JOURNAL OF BIOLOGICAL CHEMISTRY. 2004.01; 279 (4): 2438-2452. ( DOI )

  176. Atsumi T, Amengual O, Yasuda S, Koike T. Antiprothrombin antibodies-are they worth assaying? THROMBOSIS RESEARCH. 2004; 114 (5-6): 533-538. ( DOI )

  177. Yasuda S, Atsumi T, Ieko M, Koike T. beta 2-glycoprotein I, anti-beta 2-glycoprotein 1, and fibrinolysis THROMBOSIS RESEARCH. 2004; 114 (5-6): 461-465. ( DOI )

  178. T Atsumi, O Amengual, S Yasuda, T Koike. Antiprothrombin antibodies-are they worth assaying? THROMBOSIS RESEARCH. 2004; 114 (5-6): 533-538. ( DOI )

  179. Y Sakai, T Atsumi, Y Kon, M Bohgaki, S Yasuda, O Amengual, Y Amasaki, T Koike. Clinical and immunological manifestations of Japanese patients with antiphospholipid syndrome (APS): A cohort of 82 patients THROMBOSIS RESEARCH. 2004; 114 (5-6): 663-664.

  180. O Amengual, T Atsumi, K Yujiro, Y Sakai, M Bohgaki, S Furukawa, S Yasuda, Y Amasaki, M Ieko, T Koike. The value of IGM phosphatidylserine dependent antiprothrombin antibody determination for the diagnosis of antiphospholipid syndrome THROMBOSIS RESEARCH. 2004; 114 (5-6): 671-672.

  181. Y Kon, T Atsumi, M Kondo, Y Sakai, S Yasuda, Y Amasaki, T Koike. Thrombotic thrombocytopenic purpura in two patients with antiphospholipid syndrome THROMBOSIS RESEARCH. 2004; 114 (5-6): 651.

  182. S Yasuda, GW Wong, SA Krilis, RL Stevens. Activation of urokinase-type plasminogen activator (uPA) by human tryptase epsilon/PRSS22 FASEB JOURNAL. 2003.04; 17 (7): C12.

  183. GW Wong, Y Yang, S Yasuda, RL Stevens, LX Li. Mouse mast cells (MCs) express the tryptic-like serine protease neuropsin/KLK8/Prss19 FASEB JOURNAL. 2003.04; 17 (7): C11.

  184. Wong GW, Yang Y, Yasuda S, Li LX, Stevens RL. Mouse mast cells express the tryptic protease neuropsin/Prss19 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2003.03; 303 (1): 320-325. ( DOI )

  185. Wong GW, Foster PS, Yasuda S, Qi JC, Mahalingam S, Mellor EA, Katsoulotos G, Li LX, Boyce JA, Krilis SA, Stevens RL. Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase gamma JOURNAL OF BIOLOGICAL CHEMISTRY. 2002.11; 277 (44): 41906-41915. ( DOI )

  186. Yasuda S, Tsutsumi A, Atsumi T, Bertolaccini ML, Ichikawa K, Khamashta MA, Hughes GRV, Koike T. Gene polymorphisms of tissue plasminogen activator and plasminogen activator inhibitor-1 in patients with antiphospholipid antibodies JOURNAL OF RHEUMATOLOGY. 2002.06; 29 (6): 1192-1197.

  187. S Yasuda, A Tsutsumi, T Atsumi, ML Bertolaccini, K Ichikawa, MA Khamashta, GRV Hughes, T Koike. Gene polymorphisms of tissue plasminogen activator and plasminogen activator inhibitor-1 in patients with antiphospholipid antibodies JOURNAL OF RHEUMATOLOGY. 2002.06; 29 (6): 1192-1197. ( PubMed )

  188. Horita T, Tsutsumi A, Takeda T, Yasuda S, Takeuchi R, Amasaki Y, Ichikawa K, Atsumi T. Significance of magnetic resonance imaging in the diagnosis of nodular regenerative hyperplasia of the liver complicated with systemic lupus erythematosus: a case report and review of the literature LUPUS. 2002; 11 (3): 193-196.

  189. T Horita, A Tsutsumi, T Takeda, S Yasuda, R Takeuchi, Y Amasaki, K Ichikawa, T Atsumi. Significance of magnetic resonance imaging in the diagnosis of nodular regenerative hyperplasia of the liver complicated with systemic lupus erythematosus: a case report and review of the literature LUPUS. 2002; 11 (3): 193-196. ( PubMed, DOI )

  190. Wong GW, Yasuda S, Madhusudhan MS, Li LX, Yang Y, Krilis SA, Sali A, Stevens RL. Human tryptase epsilon (PRSS22), a new member of the chromosome 16p13.3 family of human serine proteases expressed in airway epithelial cells JOURNAL OF BIOLOGICAL CHEMISTRY. 2001.12; 276 (52): 49169-49182. ( DOI )

  191. Yasuda S, Tsutsumi A, Chiba H, Yanai H, Miyoshi Y, Takeuchi R, Horita T, Atsumi T, Ichikawa K, Matsuura E, Koike T. beta(2)-glycoprotein I deficiency: prevalence, genetic background and effects on plasma lipoprotein metabolism and hemostasis ATHEROSCLEROSIS. 2000.10; 152 (2): 337-346.

  192. S Yasuda, A Tsutsumi, H Chiba, H Yanai, Y Miyoshi, R Takeuchi, T Horita, T Atsumi, K Ichikawa, E Matsuura, T Koike. beta(2)-glycoprotein I deficiency: prevalence, genetic background and effects on plasma lipoprotein metabolism and hemostasis ATHEROSCLEROSIS. 2000.10; 152 (2): 337-346. ( PubMed, DOI )

  193. S Yasuda, T Atsumi, K Ichikawa, E Matsuura, K Kaihara, T Yasuda, Y Amasaki, T Koike. Valine/leucine(247) polymorphism of beta 2-glycoprotein 1 affects the reactivity of anti-beta 2-glycoprotein 1 antibodies. ARTHRITIS AND RHEUMATISM. 2000.09; 43 (9): S404.

  194. Takeuchi R, Atsumi T, Ieko M, Takeya H, Yasuda S, Ichikawa K, Tsutsumi A, Suzuki K, Koike T. Coagulation and fibrinolytic activities in 2 siblings with beta(2)-glycoprotein I deficiency BLOOD. 2000.08; 96 (4): 1594-1595.

  195. R Takeuchi, T Atsumi, M Ieko, H Takeya, S Yasuda, K Ichikawa, A Tsutsumi, K Suzuki, T Koike. Coagulation and fibrinolytic activities in 2 siblings with beta(2)-glycoprotein I deficiency BLOOD. 2000.08; 96 (4): 1594-1595. ( PubMed )

  196. A Tsutsumi, K Sasaki, R Takeuchi, T Horita, S Yasuda, Y Miyoshi, T Atsumi, K Ichikawa, T Koike. Mannose binding lectin polymorphism in patients with collagen diseases. ARTHRITIS AND RHEUMATISM. 1999.09; 42 (9): S312.

  197. T Atsumi, M Ieko, ML Bertolaccini, R Takeuchi, T Horita, S Yasuda, Y Miyoshi, K Ichikawa, A Tsutsumi, T Koike. Anti phosphatidylserine-prothrombin antibody as a specific marker for clinical features of antiphospholipid syndrome in systemic autoimmune diseases. ARTHRITIS AND RHEUMATISM. 1999.09; 42 (9): S364.

  198. S Yasuda, A Tsutsumi, T Atsumi, ML Bertolaccini, K Ichikawa, MA Khamashta, GRV Hughes, T Koike. Gene polymorphisms of tissue plasminogen activator and plasminogen activator inhibitor-1 in patients with antiphospholipid syndrome. ARTHRITIS AND RHEUMATISM. 1999.09; 42 (9): S371.

  199. Yasuda S, Tsutsumi A, Nakabayashi T, Horita T, Ichikawa K, Ieko M, Koike T. Haemophagocytic syndrome in a patient with dermatomyositis BRITISH JOURNAL OF RHEUMATOLOGY. 1998.12; 37 (12): 1357-1358.

  200. S Yasuda, A Tsutsumi, T Nakabayashi, T Horita, K Ichikawa, M Ieko, T Koike. Haemophagocytic syndrome in a patient with dermatomyositis BRITISH JOURNAL OF RHEUMATOLOGY. 1998.12; 37 (12): 1357-1358. ( PubMed )

  201. T Atsumi, M Ieko, R Takeuchi, T Horita, S Yasuda, H Kasahara, Y Miyoshi, K Ichikawa, A Tsutsumi, T Koike. Clinical significance of anti prothrombin-phosphatidylserine antibodies and their association with lupus anticoagulant in patients with autoimmune diseases. ARTHRITIS AND RHEUMATISM. 1998.09; 41 (9): S169.

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Conference Activities & Talks 【 display / non-display 】

  1. 嶋村 抄苗, 保田 晋助, 河野 通仁, 藤枝 雄一郎, 加藤 将, 奥 健志, 渥美 達也. 関節リウマチ患者の線維芽細胞様滑膜細胞においてfarnesyltransferase阻害薬はRasGRP4-RAS-MAPキナーゼ経路を抑制する(Farnesyltransferase inhibitor suppresses the RasGRP4-Ras- MAP kinase pathway in fibroblast-like synoviocytes from patients with rheumatoid arthritis). 日本臨床免疫学会総会プログラム・抄録集 2019.10.01

  2. 中川 久子, 保田 晋助, 松浦 栄次, 小林 和子, 家子 正裕, 片岡 浩, 堀田 哲也, 渥美 達也, 小池 隆夫. ニックβ2-糖蛋白質Iはアンギオスタチン4.5と結合しその血管新生阻害を減弱化する(Nicked β2-glycoprotein I binds angiostatin 4.5 and attenuates its anti-angiogenic property). 日本血栓止血学会誌 2010.04.01

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Others 【 display / non-display 】

  • Finding the source of debilitating, body-wide muscular pain and weakness，2023.12

  • When it comes to COVID-19, belly fat upsets the apple cart，2023.06

  • A novel drug suppresses muscle inflammation and restores muscle weakness，2022.08

  • Targeting necroptosis for inflammatory myopathies，2022.03

    AAAS EurekAlert! The Global Source for Science News

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Campus class subject 【 display / non-display 】

  • Dermatology, Allergology and Rheumatology，2020

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