Graduating School 【 display / non-display 】

  • The University of Tokyo, Faculty of Pharmaceutical Science, 2003.03, Graduated

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Graduate School 【 display / non-display 】

  • The University of Tokyo, Graduate School, Division of Pharmaceutical Sciences, Master's Course, 2005.03, Completed

  • The University of Tokyo, Graduate School, Division of Pharmaceutical Sciences, Doctor's Course, 2008.03, Accomplished credits for doctoral program

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Campus Career 【 display / non-display 】

  • 2019.12
    -
    2022.04
    Tokyo Medical and Dental University， Medical Research Institute， Pathophysiology， Developmental and Regenerative Biology， Junior Associate Professor
  • 2022.05
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    2023.04
    Tokyo Medical and Dental University， Medical Research Institute， Division of Visionary Life Science， Department of Developmental and Regenerative Biology， Junior Associate Professor
  • 2023.05
    -
    Now
    Tokyo Medical and Dental University， Medical Research Institute， Division of Visionary Life Science， Department of Developmental and Regenerative Biology， Junior Associate Professor
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External Career 【 display / non-display 】

  • 2008.04
    -
    2008.07
    , Project Researcher
  • 2008.08
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    2009.03
    , Project Assistant Professor
  • 2009.04
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    2012.03
    , Project Assistant Professor
  • 2013.12
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    2014.03
    , Project Assistant Professor
  • 2017.06
    -
    2019.03
    , Assistant Professor
  • 2019.04
    -
    2019.11
    , Assistant Professor

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Academic Society Affiliations 【 display / non-display 】

  • The Japasense Society for Cell Death Research

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Research Areas 【 display / non-display 】

  • Pathological biochemistry

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Qualification Acquired 【 display / non-display 】

  • Pharmacist

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Published Papers & Misc 【 display / non-display 】

  1. Kofuji S, Wolfe K, Sumita K, Kageyama S, Yoshino H, Hirota Y, Ogawa-Iio A, Kanoh H, Sasaki M, Kofuji K, Davis MI, Pragani R, Shen M, Boxer MB, Nakatsu F, Nigorikawa K, Sasaki T, Takeuchi K, Senda T, Kim SM, Edinger AL, Simeonov A, Sasaki AT. A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion. Biochemical and biophysical research communications. 2024.07; 718 149981. ( PubMed, DOI )

  2. Pu J, Kofuji S, Okamoto-Uchida Y, Danzaki K, Yu R, Suzuki A, Kitajima S, Nishina H. Lethal Phenotype-Based Database Screening Identifies Ceramide as a Negative Regulator of Primitive Streak Formation. Stem cells (Dayton, Ohio). 2023.10; 41 (12): 1142-1156. ( PubMed, DOI )

  3. Ikeda Y, Davis MI, Sumita K, Zheng Y, Kofuji S, Sasaki M, Hirota Y, Pragani R, Shen M, Boxer MB, Takeuchi K, Senda T, Simeonov A, Sasaki AT. Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells. Biochemical and biophysical research communications. 2023.08; 679 116-121. ( PubMed, DOI )

  4. Sakurai HT, Iwashita H, Arakawa S, Yikelamu A, Kusaba M, Kofuji S, Nishina H, Ishiyama M, Ueno Y, Shimizu S. Development of small fluorescent probes for the analysis of autophagy kinetics. iScience. 2023.07; 26 (7): 107218. ( PubMed, DOI )

  5. Jing Pu, Satoshi Kofuji, Yoshimi Okamoto-Uchida, Keiko Danzaki, Ruoxing Yu, Akira Suzuki, Satoshi Kitajima and Hiroshi Nishina. Lethal phenotype-based database screening identifies ceramide as a negative regulator of primitive streak formation. Stem Cells. 2023;

  6. Oda C, Kamimura K, Shibata O, Morita S, Tanaka Y, Setsu T, Abe H, Yokoo T, Sakamaki A, Kamimura H, Kofuji S, Wakai T, Nishina H, Terai S. HBx and YAP expression could promote tumor development and progression in HBV-related hepatocellular carcinoma. Biochemistry and biophysics reports. 2022.12; 32 101352. ( PubMed, DOI )

  7. Kobayashi S, Ogasawara N, Watanabe S, Yoneyama Y, Kirino S, Hiraguri Y, Inoue M, Nagata S, Okamoto-Uchida Y, Kofuji S, Shimizu H, Ito G, Mizutani T, Yamauchi S, Kinugasa Y, Kano Y, Nemoto Y, Watanabe M, Tsuchiya K, Nishina H, Okamoto R, Yui S. Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation. Inflammation and Regeneration. 2022.11; 42 (1): 49. ( PubMed, DOI )

  8. Kobayashi Sakurako, Ogasawara Nobuhiko, Watanabe Satoshi, Yoneyama Yosuke, Kirino Sakura, Hiraguri Yui, Inoue Masami, Nagata Sayaka, Okamoto-Uchida Yoshimi, Kofuji Satoshi, Shimizu Hiromichi, Ito Go, Mizutani Tomohiro, Yamauchi Shinichi, Kinugasa Yusuke, Kano Yoshihito, Nemoto Yasuhiro, Watanabe Mamoru, Tsuchiya Kiichiro, Nishina Hiroshi, Okamoto Ryuichi, Yui Shiro. コラーゲンI型を介した機械的シグナル伝達は腸炎時の上皮細胞の運命転換を制御する(Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation) Inflammation and Regeneration. 2022.11; 42 1 of 18-18 of 18. ( ichushi )

  9. Shibata T, Kawana H, Nishino Y, Ito Y, Sato H, Onishi H, Kano K, Inoue A, Taketomi Y, Murakami M, Kofuji S, Nishina H, Miyazawa A, Kono N, Aoki J. Abnormal male reproduction and embryonic development induced by downregulation of a phospholipid fatty acid-introducing enzyme Lpgat1 in zebrafish. Scientific reports. 2022.05; 12 (1): 7312. ( PubMed, DOI )

  10. Ikeda Yoshiki, Hirayama Akiyoshi, Kofuji Satoshi, Hirota Yoshihisa, Kamata Ryo, Osaka Natsuki, Fujii Yuki, Sasaki Mika, Ikeda Satsuki, Smith Eric P., Bachoo Robert, Soga Tomoyoshi, Sasaki Atsuo T.. SI-MOIRAI: a new method to identify and quantify the metabolic fate of nucleotides(和訳中) The Journal of Biochemistry. 2021.12; 170 (6): 699-711. ( ichushi )

  11. Sunaga S, Kofuji S, Nishina H. YAP drives cell competition by activating choline metabolism. Biochemical and biophysical research communications. 2021.08; 572 178-184. ( PubMed, DOI )

  12. Alifu Y, Kofuji S, Sunaga S, Kusaba M, Hirayama J, Nishina H. The Light-Inducible Genes Per2, Cry1a, and Cry2a Regulate Oxidative Status in Zebrafish. Biological & pharmaceutical bulletin. 2021.08; 44 (8): 1160-1165. ( PubMed, DOI )

  13. Alifu Yikelamu, Kofuji Satoshi, Sunaga Sachi, Kusaba Mizuki, Hirayama Jun, Nishina Hiroshi. The Light-Inducible Genes Per2, Cry1a, and Cry2a Regulate Oxidative Status in Zebrafish(和訳中) Biological & Pharmaceutical Bulletin. 2021.08; 44 (8): 1160-1165. ( ichushi )

  14. Ikeda Y, Hirayama A, Kofuji S, Hirota Y, Kamata R, Osaka N, Fujii Y, Sasaki M, Ikeda S, Smith EP, Bachoo R, Soga T, Sasaki AT. SI-MOIRAI: A new method to identify and quantify the metabolic fate of nucleotides. Journal of biochemistry. 2021.07; 170 (6): 699-711. ( PubMed, DOI )

  15. Shin T, Hiraoka Y, Yamasaki T, Marth JD, Penninger JM, Kanai-Azuma M, Tanaka K, Kofuji S, Nishina H. MKK7 deficiency in mature neurons impairs parental behavior in mice. Genes to cells : devoted to molecular & cellular mechanisms. 2020.10; 26 (1): 5-17. ( PubMed, DOI )

  16. Kofuji Satoshi, Sasaki Atsuo T.. GTP metabolic reprogramming by IMPDH2: unlocking cancer cells' fuelling mechanism(和訳中) The Journal of Biochemistry. 2020.10; 168 (4): 319-328. ( ichushi )

  17. Kofuji S, Sasaki AT. GTP Metabolic Reprogramming by IMPDH2: Unlocking Cancer Cells' Fueling Mechanism. Journal of biochemistry. 2020.07; 168 (4): 319-328. ( PubMed, DOI )

  18. Ishihara E, Nagaoka Y, Okuno T, Kofuji S, Ishigami-Yuasa M, Kagechika H, Kamimura K, Terai S, Yokomizo T, Sugimoto Y, Fujita Y, Suzuki A, Nishina H. Prostaglandin E<sub>2</sub> and its receptor EP2 trigger signaling that contributes to YAP-mediated cell competition. Genes to cells : devoted to molecular & cellular mechanisms. 2020.03; 25 (3): 197-214. ( PubMed, DOI )

  19. Naffouje R, Grover P, Yu H, Sendilnathan A, Wolfe K, Majd N, Smith EP, Takeuchi K, Senda T, Kofuji S, Sasaki AT. Anti-Tumor Potential of IMP Dehydrogenase Inhibitors: A Century-Long Story. Cancers. 2019.09; 11 (9): ( PubMed, DOI )

  20. Takemasu S, Nigorikawa K, Yamada M, Tsurumi G, Kofuji S, Takasuga S, Hazeki K. Phosphorylation of TMEM55B by Erk/MAPK regulates lysosomal positioning. Journal of biochemistry. 2019.08; 166 (2): 175-185. ( PubMed, DOI )

  21. Kofuji S, Hirayama A, Eberhardt AO, Kawaguchi R, Sugiura Y, Sampetrean O, Ikeda Y, Warren M, Sakamoto N, Kitahara S, Yoshino H, Yamashita D, Sumita K, Wolfe K, Lange L, Ikeda S, Shimada H, Minami N, Malhotra A, Morioka S, Ban Y, Asano M, Flanary VL, Ramkissoon A, Chow LML, Kiyokawa J, Mashimo T, Lucey G, Mareninov S, Ozawa T, Onishi N, Okumura K, Terakawa J, Daikoku T, Wise-Draper T, Majd N, Kofuji K, Sasaki M, Mori M, Kanemura Y, Smith EP, Anastasiou D, Wakimoto H, Holland EC, Yong WH, Horbinski C, Nakano I, DeBerardinis RJ, Bachoo RM, Mischel PS, Yasui W, Suematsu M, Saya H, Soga T, Grummt I, Bierhoff H, Sasaki AT. IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma. Nature cell biology. 2019.08; 21 (8): 1003-1014. ( PubMed, DOI )

  22. Wolfe K, Kofuji S, Yoshino H, Sasaki M, Okumura K, Sasaki AT. Dynamic compartmentalization of purine nucleotide metabolic enzymes at leading edge in highly motile renal cell carcinoma. Biochemical and biophysical research communications. 2019.08; 516 (1): 50-56. ( PubMed, DOI )

  23. Takemasu Shinya, Nigorikawa Kiyomi, Yamada Miho, Tsurumi Go, Kofuji Satoshi, Takasuga Shunsuke, Hazeki Kaoru. Erk/MAPKによるTMEM55Bのリン酸化はリソソームのポジショニングを制御する(Phosphorylation of TMEM55B by Erk/MAPK regulates lysosomal positioning) The Journal of Biochemistry. 2019.08; 166 (2): 175-185. ( ichushi )

  24. Nigorikawa Kiyomi, Matsumura Takuma, Sakamoto Hiromi, Morioka Shin, Kofuji Satoshi, Takasuga Shunsuke, Hazeki Kaoru. Sac1ホスホイノシチドホスファターゼは、マクロファージにおけるSR-A発現を調節することにより、泡沫細胞の形成を制御する(Sac1 Phosphoinositide Phosphatase Regulates Foam Cell Formation by Modulating SR-A Expression in Macrophages) Biological & Pharmaceutical Bulletin. 2019.06; 42 (6): 923-928. ( ichushi )

  25. Takemasu S, Ito M, Morioka S, Nigorikawa K, Kofuji S, Takasuga S, Eguchi S, Nakanishi H, Matsuoka I, Sasaki J, Sasaki T, Hazeki K. Lysophosphatidylinositol-acyltransferase-1 is involved in cytosolic Ca<sup>2+</sup> oscillations in macrophages. Genes to cells : devoted to molecular & cellular mechanisms. 2019.05; 24 (5): 366-376. ( PubMed, DOI )

  26. Isobe Y, Nigorikawa K, Tsurumi G, Takemasu S, Takasuga S, Kofuji S, Hazeki K. PIKfyve accelerates phagosome acidification through activation of TRPML1 while arrests aberrant vacuolation independent of the Ca2+ channel. Journal of biochemistry. 2019.01; 165 (1): 75-84. ( PubMed, DOI )

  27. Isobe Yuri, Nigorikawa Kiyomi, Tsurumi Go, Takemasu Shinya, Takasuga Shunsuke, Kofuji Satoshi, Hazeki Kaoru. PIKfyveはTRPML1活性化を介してファゴソーム酸性化を促進するが、Ca2+チャネルとは無関係に異常な空胞形成を阻止する(PIKfyve accelerates phagosome acidification through activation of TRPML1 while arrests aberrant vacuolation independent of the Ca2+ channel) The Journal of Biochemistry. 2019.01; 165 (1): 75-84. ( ichushi )

  28. Yoshino H, Yin G, Kawaguchi R, Popov KI, Temple B, Sasaki M, Kofuji S, Wolfe K, Kofuji K, Okumura K, Randhawa J, Malhotra A, Majd N, Ikeda Y, Shimada H, Kahoud ER, Haviv S, Iwase S, Asara JM, Campbell SL, Sasaki AT. Correction: Identification of lysine methylation in the core GTPase domain by GoMADScan. PloS one. 2019; 14 (10): e0224443. ( PubMed, DOI )

  29. Nigorikawa K, Matsumura T, Sakamoto H, Morioka S, Kofuji S, Takasuga S, Hazeki K. Sac1 Phosphoinositide Phosphatase Regulates Foam Cell Formation by Modulating SR-A Expression in Macrophages. Biological & pharmaceutical bulletin. 2019; 42 (6): 923-928. ( PubMed, DOI )

  30. Yoshino H, Yin G, Kawaguchi R, Popov KI, Temple B, Sasaki M, Kofuji S, Wolfe K, Kofuji K, Okumura K, Randhawa J, Malhotra A, Majd N, Ikeda Y, Shimada H, Kahoud ER, Haviv S, Iwase S, Asara JM, Campbell SL, Sasaki AT. Identification of lysine methylation in the core GTPase domain by GoMADScan. PloS one. 2019; 14 (8): e0219436. ( PubMed, DOI )

  31. 劉 瀟瀟, 合山 進, 四方 紫織, 林 康貴, 岩村 浩幸, 齊藤 基輝, 杉浦 悠毅, 滝澤 仁, 小藤 智史, 壽美田 一貴, 佐々木 敦朗, Schibler Janet, Mulloy James C., 北村 俊雄. IMPDH阻害剤による新規白血病治療法の開発 生命科学系学会合同年次大会. 2017.12; 2017年度 [1P-0963]. ( ichushi )

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Conference Activities & Talks 【 display / non-display 】

  1. Junjie Chen, Hiroshi Nishina, Satoshi Kofuji. Generation of a p15/16 reporter turquoise killifish to study cellular senescence. 18TH INTERNATIONAL ZEBRAFISH CONFERENCE 2024.08.18 Kyoto

  2. Satoshi Kofuji. Identification of metabolic pathways regulating early mouse embryogenesis. The 18th international Symposium of the institute Network for Biomedical Science The 2nd symposium of Medical Reserch Center Initiative for High Depth Omics The 21st Surugadai International Symposium 2023.10.05 東京・東京医科歯科大学

  3. Chen Junjie, Satoshi Kofuji, Hiroshi Nishina. Characterization of aging phenotypes in African turquoise killifish. 第22回 次世代を担う若手のためのファーマ・バイオフォーラム 2023 2023.09.08 福岡・九州大学

  4. Satoshi Kofuji, Hiroshi Nagao, Hiroshi Nishina. Regulation of liver regeneration by the neural MKK7-JNK pathway in an age-dependent manner. Japan and Australia Meeting on Cell Death 2023 2023.08.17 Melbourne, Australia

  5. Jing Pu,Satoshi Kofuji,Hiroshi Nishina. Identification of ceramide as a negative regulator of primitive streak formation. 2022年度日本生化学会関東支部例会 2022.06.18

  6. Satoshi Kofuji, Atsuo T Sasaki. A chemical-induced catastrophic vacuolization: potential anti-tumor effect . 第43回日本分子生物学会 2020.12.04

  7. 小藤智史, 佐々木敦朗. GTP-metabolic reprograming that regulates the nucleolar activity and tumorigenesis . 第42回日本分子生物学会年会 2019.12.04

  8. 小藤智史. GTP metabolic switch drives cellular mass anabolism for glioblastomagenesis. Jensen Symposium on Breast Cancer 2016.11

  9. 小藤智史. Dynamic role of GTP metabolism in cancers. Cancer Metabolism Symposium 2016.05

  10. 小藤智史. GTP metabolic switch promotes malignant growth of brain tumors. American Society for Cell Biology (ASCB) Annual Meeting 2015.12

  11. 小藤智史. Dynamic Role of GTP-Metabolism in Glioblastoma. Cancer Biology & Hematology/Oncology Joint Retreat 2015.11

  12. 小藤智史. The novel mechanism of tumor suppression by inositol polyphosphate 4-phosphatase type II . The 8th Japan-Korea conference on cellular signaling for young scientists 2013.11

  13. 小藤智史. Genetic Screening for genes involved in apical trafficking using C. elegans. The 20th International Union of Biochemistry and Molecular Biology (IUBMB) 2006.06

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Awards & Honors 【 display / non-display 】

  • UJA Paper Award，United Japanese researchers Around the world，2021.04

  • UJA Midwest Conference 2016, Presentation Award，2016.11

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Performance of duties 【 display / non-display 】

  • ，2022.04 - Now

  • ，2020.09 - Now

  • ，2020.04 - Now

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