Personnel Information

写真a

TAZAWA Ryushi


Job title

Professor

Research Areas, Keywords

internal medicine, health care, respiratory diseases, medical genetics
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Graduating School 【 display / non-display 】

  • Tokyo Medical and Dental University, Faculty of Medicine, 1988.03, Graduated

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Graduate School 【 display / non-display 】

  • Tokyo Medical and Dental University, Graduate School, Division of Medicine, Doctor's Course, 1993.03, Completed

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Campus Career 【 display / non-display 】

  • 2019.06
    -
    Now
    Tokyo Medical and Dental University， Student Support and Health Administration Organization， Health Administration Center， Professor
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External Career 【 display / non-display 】

  • 2018.06
    -
    2019.05
    Niigata University Medical and Dental Hospital, Center for Medical Genetics Service and Genetic Counseling, Associate Professor / Hospital Professor
  • 2013.06
    -
    2018.05
    Niigata University Medical and Dental Hospital, Bioscience Medical Research Center, Associate Professor
  • 2008.09
    -
    2008.12
    Cincinnati Children's Hospital Medical Center, Lung Biology Division, Visiting Scientist
  • 2008.03
    -
    2013.05
    Niigata University Medical and Dental Hospital, Bioscience Medical Research Center, Junior Associate Professor
  • 2004.09
    -
    2008.02
    Tohoku University Hospital, Department of Respiratory Medicine and Translational Research Clinic, Chief of Medical Staff
  • 2003.04
    -
    2004.08
    Tohoku University Hospital, Department of Respiratory Medicine and Translational Research Clinic, Chief of Ward Staff
  • 2003.03
    -
    2008.02
    Tohoku Univeristy Hospital, Department of Respiratory Medicine and Translational Research Clinic, Assistant Professor
  • 1997.10
    -
    2003.02
    Institute of Development, Aging, and Cancer, Tohoku University, Department of Respiratory Oncology and Molecular Medicine, Instructor
  • 1997.07
    -
    1997.09
    Attached Hospital of Institute of Development, Aging, and Cancer, Tohoku University, Department of Internal Medicine, Clinical Fellow
  • 1996.10
    -
    1997.06
    Sennan Hospital, Kakuda, Miyagi Pref., Department of Internal Medicine, Chief Physician
  • 1996.04
    -
    1996.09
    Attached Hospital of Institute of Development, Aging, and Cancer, Tohoku University, Department of Internal Medicine, Clinical Fellow
  • 1993.01
    -
    1996.03
    University of Texas Medical School at Houston, Department of Internal Medicine, Postdoctoral Research Fellow
  • 1989.04
    -
    1990.03
    Hitachi General Hospital, Hitachi, Ltd., Department of Internal Medicine, Resident
  • 2016.08
    -
    2019.05
    Ethics Committee of Niigata University, member
  • 2016.08
    -
    2019.05
    Ethics Committee on Genetic Analysis of Niigata University, member
  • 2013.04
    -
    2016.07
    Ethics Committee, School of Medicine, Niigata University, member
  • 2008.05
    -
    2016.07
    Ethics Committee on Genetic Analysis, School of Medicine, Niigata University, member
  • 2004.09
    -
    2008.02
    Internal Review Board, Tohoku University Hospital, member

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Academic Society Affiliations 【 display / non-display 】

  • The Japanese Society of Internal Medicine

  • The Japanese Respiratory Society

  • Japanese Cancer Association

  • American Thoracic Society

  • The Japan Society of Human Genetics

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Academic Activity 【 display / non-display 】

  • 2017
    -
    Now
    The Japan Respiratory Society Editorial Board of Respiratoy Investigation
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Research Areas 【 display / non-display 】

  • General internal medicine

  • Medical management and medical sociology

  • Respiratory medicine

  • Medical biochemistry

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Qualification Acquired 【 display / non-display 】

  • Fellow of the Japanese Society of Internal Medicine

  • Certified Occupational Health Physician

  • Senior Fellow of the Japanese Respiratory Society

  • Board Certified Member of the Japanese Respiratory Society

  • Certified Specialist in Medical Genetics (Japanese Board of Medical Genetics and Genomics)

  • Doctor

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Published Papers & Misc 【 display / non-display 】

  1. Ryushi Tazawa, Riuko Ohashi, Nobutaka Kitamura, Takahiro Tanaka, Kazuhide Nakagaki, Sachiko Yuki, Atsushi Fujiwara, Koh Nakata. Repeated inhalation of GM-CSF by nonhuman primates induces bronchus-associated lymphoid tissue along the lower respiratory tract. Respiratory Research. 2024.11; 25 (1): ( DOI )

  2. Shigeki Shimasaki, Tomohisa Baba, Takashi Ogura, Keiichi Akasaka, Hidekazu Matsushima, Shinyu Izumi, Jin Takasaki, Kenji Tsushima, Toru Kinouchi, Yoshiko Kichikawa, Maiko Awashima, Takehiro Izumo, Nobuyasu Awano, Naoki Nishimura, Ryushi Tazawa, Ayako Mikami, Nobutaka Kitamura, Haruyuki Ishii, Yasuyuki Kurihara, Masaki Taniguchi, Satoko Aikawa, Mami Okada, Yusuke Morita, Yuko Ishikawa, Akira Ohinata, Koh Nakata. Short-term inhalation of sargramostim with concomitant high-dose steroids does not hasten recovery in moderate COVID-19 pneumonia: a double-blind, randomised, placebo-controlled trial. Infect Dis (Lond). 2023.12; 55 (12): 857-873. ( PubMed, DOI )

  3. Miku Oda, Kentaro Yamaura, Haruyuki Ishii, Nobutaka Kitamura, Ryushi Tazawa, Mitsuhiro Abe, Koichiro Tatsumi, Ryosuke Eda, Shotaro Kondoh, Konosuke Morimoto, Takeshi Tanaka, Etsuro Yamaguchi, Ayumu Takahashi, Shinyu Izumi, Haruhito Sugiyama, Atsushi Nakagawa, Keisuke Tomii, Masaru Suzuki, Satoshi Konno, Shinya Ohkouchi, Naoki Tode, Tomohiro Handa, Toyohiro Hirai, Yoshikazu Inoue, Toru Arai, Katsuaki Asakawa, Takahiro Tanaka, Toshinori Takada, Hirofumi Nonaka, Koh Nakata. Quantitative Evaluation of Changes in Three-Dimensional CT Density Distributions in Pulmonary Alveolar Proteinosis after GM-CSF Inhalation. Respiration. 2023.02; 102 (2): 101-109. ( PubMed, DOI )

  4. Spyros A Papiris, Ilaria Campo, Francesca Mariani, Maria Kallieri, Lykourgos Kolilekas, Andriana I Papaioannou, Efsun Gonca Chousein, Erdogan Cetinkaya, Francesco Bonella, Raphael Borie, Maria Kokosi, Thomas Pickworth, Maria Molina-Molina, Mercè Gasa, Elżbieta Radzikowska, Justyna Fijolek, Stéphane Jouneau, Emmanuel Gomez, Cormac McCarthy, Elisabeth Bendstrup, Wojciech J Piotrowski, Rishi Pabary, Alice Hadchouel, Nathalie Coolen-Allou, Tiago Alfaro, Carlos Robalo Cordeiro, Elvira-Markela Antonogiannaki, Ioannis P Tomos, Despoina Papakosta, Theodoros Kontakiotis, Panagiota Panagiotou, Konstantinos Douros, Andrea Schams, Sara Lettieri, Vassiliki Papaevangelou, Christina Kanaka-Gantenbein, Anna Karakatsani, Stelios Loukides, Ulrich Costabel, Bruno Crestani, Cliff Morgan, Ryushi Tazawa, Andrew Bush, Matthias Griese, Effrosyni D Manali. COVID-19 in patients with pulmonary alveolar proteinosis: a European multicentre study. ERJ Open Res. 2023.01; 9 (1): ( PubMed, DOI )

  5. Shinya Ohkouchi, Masahiko Kanehira, Daisuke Saigusa, Manabu Ono, Ryushi Tazawa, Hideya Terunuma, Taizou Hirano, Tadahisa Numakura, Hirotsugu Notsuda, Chihiro Inoue, Ryoko Saito-Koyama, Masao Tabata, Toshiya Irokawa, Hiromasa Ogawa, Hajime Kurosawa, Yoshinori Okada. Metabolic and Epigenetic Regulation of SMAD7 by STC1 Ameliorates Lung Fibrosis. Am J Respir Cell Mol Biol. 2022.09; 67 (3): 320-333. ( PubMed, DOI )

  6. Hiroki Maruyama, Atsumi Taguchi, Mariko Mikame, Atsushi Izawa, Naoki Morito, Kazufumi Izaki, Toshiyuki Seto, Akifumi Onishi, Hitoshi Sugiyama, Norio Sakai, Kenji Yamabe, Yukio Yokoyama, Satoshi Yamashita, Hiroshi Satoh, Shigeru Toyoda, Michihiro Hosojima, Yumi Ito, Ryushi Tazawa, Satoshi Ishii. Plasma Globotriaosylsphingosine and α-Galactosidase A Activity as a Combined Screening Biomarker for Fabry Disease in a Large Japanese Cohort. Curr Issues Mol Biol. 2021.06; 43 (1): 389-404. ( PubMed, DOI )

  7. Saori Sakaue, Etsuro Yamaguchi, Yoshikazu Inoue, Meiko Takahashi, Jun Hirata, Ken Suzuki, Satoru Ito, Toru Arai, Masaki Hirose, Yoshinori Tanino, Takefumi Nikaido, Toshio Ichiwata, Shinya Ohkouchi, Taizou Hirano, Toshinori Takada, Satoru Miyawaki, Shogo Dofuku, Yuichi Maeda, Takuro Nii, Toshihiro Kishikawa, Kotaro Ogawa, Tatsuo Masuda, Kenichi Yamamoto, Kyuto Sonehara, Ryushi Tazawa, Konosuke Morimoto, Masahiro Takaki, Satoshi Konno, Masaru Suzuki, Keisuke Tomii, Atsushi Nakagawa, Tomohiro Handa, Kiminobu Tanizawa, Haruyuki Ishii, Manabu Ishida, Toshiyuki Kato, Naoya Takeda, Koshi Yokomura, Takashi Matsui, Masaki Watanabe, Hiromasa Inoue, Kazuyoshi Imaizumi, Yasuhiro Goto, Hiroshi Kida, Tomoyuki Fujisawa, Takafumi Suda, Takashi Yamada, Yasuomi Satake, Hidenori Ibata, Nobuyuki Hizawa, Hideki Mochizuki, Atsushi Kumanogoh, Fumihiko Matsuda, Koh Nakata, Tomomitsu Hirota, Mayumi Tamari, Yukinori Okada. Genetic determinants of risk in autoimmune pulmonary alveolar proteinosis. Nat Commun. 2021.02; 12 (1): 1032. ( PubMed, DOI )

  8. Ryushi Tazawa, Nobutaka Kitamura, Koh Nakata. Inhaled GM-CSF for Pulmonary Alveolar Proteinosis. Reply. N. Engl. J. Med.. 2020.01; 382 (2): 198. ( PubMed, DOI )

  9. Koh Nakata, Tatsuki Sugi, Keiko Kuroda, Kazutaka Yoshizawa, Toshinori Takada, Ryushi Tazawa, Takahiro Ueda, Ami Aoki, Mitsuhiro Abe, Koichiro Tatsumi, Ryosuke Eda, Shotaro Kondoh, Konosuke Morimoto, Takeshi Tanaka, Etsuro Yamaguchi, Ayumu Takahashi, Miku Oda, Haruyuki Ishii, Shinyu Izumi, Haruhito Sugiyama, Atsushi Nakagawa, Keisuke Tomii, Masaru Suzuki, Satoshi Konno, Shinya Ohkouchi, Taizou Hirano, Tomohiro Handa, Toyohiro Hirai, Yoshikazu Inoue, Toru Arai, Katsuaki Asakawa, Takuro Sakagami, Takahiro Tanaka, Ayako Mikami, Nobutaka Kitamura. Validation of a new serum granulocyte-macrophage colony-stimulating factor autoantibody testing kit. ERJ Open Res. 2020.01; 6 (1): ( PubMed, DOI )

  10. Yoshitaka Uchida, Kazuyuki Nakagome, Ryushi Tazawa, Keiichi Akasaka, Masayuki Ito, Yoshiyuki Haga, Ken-Ichiro Komiyama, Tomoyuki Soma, Koh Nakata, Makoto Nagata. Modified eosinophil adhesion in pulmonary alveolar proteinosis caused by CSF2RA deletion. Allergol Int. 2019.09; 68S S14-S16. ( PubMed, DOI )

  11. Ryushi Tazawa, Takahiro Ueda, Mitsuhiro Abe, Koichiro Tatsumi, Ryosuke Eda, Shotaro Kondoh, Konosuke Morimoto, Takeshi Tanaka, Etsuro Yamaguchi, Ayumu Takahashi, Miku Oda, Haruyuki Ishii, Shinyu Izumi, Haruhito Sugiyama, Atsushi Nakagawa, Keisuke Tomii, Masaru Suzuki, Satoshi Konno, Shinya Ohkouchi, Naoki Tode, Tomohiro Handa, Toyohiro Hirai, Yoshikazu Inoue, Toru Arai, Katsuaki Asakawa, Takuro Sakagami, Atsushi Hashimoto, Takahiro Tanaka, Toshinori Takada, Ayako Mikami, Nobutaka Kitamura, Koh Nakata. Inhaled GM-CSF for Pulmonary Alveolar Proteinosis. N. Engl. J. Med.. 2019.09; 381 (10): 923-932. ( PubMed, DOI )

  12. Takahito Nei, Shinya Urano, Natsuki Motoi, Atsushi Hashimoto, Nobutaka Kitamura, Takahiro Tanaka, Kazuhide Nakagaki, Jun Takizawa, Chinatsu Kaneko, Ryushi Tazawa, Koh Nakata. Memory B cell pool of autoimmune pulmonary alveolar proteinosis patients contains higher frequency of GM-CSF autoreactive B cells than healthy subjects. Immunol. Lett.. 2019.06; 212 22-29. ( PubMed, DOI )

  13. Nobutaka Kitamura, Shinya Ohkouchi, Ryushi Tazawa, Haruyuki Ishii, Toshinori Takada, Takuro Sakagami, Takahiro Tanaka, Koh Nakata. Incidence of autoimmune pulmonary alveolar proteinosis estimated using Poisson distribution. ERJ Open Res. 2019.02; 5 (1): ( PubMed, DOI )

  14. Hiroki Maruyama, Kaori Miyata, Mariko Mikame, Atsumi Taguchi, Chu Guili, Masaru Shimura, Kei Murayama, Takeshi Inoue, Saori Yamamoto, Koichiro Sugimura, Koichi Tamita, Toshihiro Kawasaki, Jun Kajihara, Akifumi Onishi, Hitoshi Sugiyama, Teiko Sakai, Ichijiro Murata, Takamasa Oda, Shigeru Toyoda, Kenichiro Hanawa, Takeo Fujimura, Shigehisa Ura, Mimiko Matsumura, Hideki Takano, Satoshi Yamashita, Gaku Matsukura, Ryushi Tazawa, Tsuyoshi Shiga, Mio Ebato, Hiroshi Satoh, Satoshi Ishii. Effectiveness of plasma lyso-Gb3 as a biomarker for selecting high-risk patients with Fabry disease from multispecialty clinics for genetic analysis. Genet. Med.. 2018.09; 21 (1): 44-52. ( PubMed, DOI )

  15. Ryu Nakano, Kazuhide Nakagaki, Yuko Itoh, Utako Seino, Takahiro Ueda, Ryushi Tazawa, Nobutaka Kitamura, Takahiro Tanaka, Koh Nakata. Assay system development to measure the concentration of sargramostim with high specificity in patients with autoimmune pulmonary alveolar proteinosis after single-dose inhalation. J. Immunol. Methods. 2018.09; 460 1-9. ( PubMed, DOI )

  16. Ami Hemmi, Ken Okamura, Ryushi Tazawa, Yuko Abe, Masahiro Hayashi, Shuji Izumi, Jun Tohyama, Yutaka Shimomura, Yutaka Hozumi, Tamio Suzuki. Waardenburg syndrome type IIE in a Japanese patient caused by a novel non-frame-shift duplication mutation in the SOX10 gene. J. Dermatol.. 2018.05; 45 (5): e110-e111. ( PubMed, DOI )

  17. Taizou Hirano, Shinya Ohkouchi, Naoki Tode, Makoto Kobayashi, Manabu Ono, Teruyuki Satoh, Yoichiro Mitsuishi, Akira Watanabe, Masao Tabata, Toshiya Irokawa, Hiromasa Ogawa, Hisatoshi Sugiura, Toshiaki Kikuchi, Keiichi Akasaka, Ryushi Tazawa, Yoshikazu Inoue, Koh Nakata, Hajime Kurosawa, Masakazu Ichinose. Peripheral alveolar nitric oxide concentration reflects alveolar inflammation in autoimmune pulmonary alveolar proteinosis. ERJ Open Res. 2018.01; 4 (1): ( PubMed, DOI )

  18. Nobutaka Kitamura, Kuniaki Seyama, Yoshikazu Inoue, Katsura Nagai, Masaru Suzuki, Hiroshi Moriyama, Toshinori Takada, Ryushi Tazawa, Toyohiro Hirai, Michiaki Mishima, Mie Hayashida, Masaki Hirose, Toru Arai, Chikatoshi Sugimoto, Noboru Hattori, Kentaro Watanabe, Tsutomu Tamada, Kohei Akazawa, Takahiro Tanaka, Koh Nakata. Risk factors for stomatitis in patients with lymphangioleiomyomatosis during treatment with sirolimus: A multicenter investigator-initiated prospective study. Pharmacoepidemiol Drug Saf. 2017.10; 26 (10): 1182-1189. ( PubMed, DOI )

  19. Sayoko Tokura, Masanori Akira, Tomohisa Okuma, Ryushi Tazawa, Toru Arai, Chikatoshi Sugimoto, Akiko Matsumuro, Masaki Hirose, Toshinori Takada, Koh Nakata, Haruyuki Ishii, Yasunori Kasahara, Masayuki Hojo, Shinya Ohkouchi, Yoshiko Tsuchihashi, Masanori Yokoba, Ryosuke Eda, Hideaki Nakayama, Takahito Nei, Konosuke Morimoto, Yasuyuki Nasuhara, Masahito Ebina, Toshio Ichiwata, Koichiro Tatsumi, Etsuro Yamaguchi, Yoshikazu Inoue. A Semiquantitative Computed Tomographic Grading System for Evaluating Therapeutic Response in Pulmonary Alveolar Proteinosis. Ann Am Thorac Soc. 2017.09; 14 (9): 1403-1411. ( PubMed, DOI )

  20. Shinya Ohkouchi, Keiichi Akasaka, Toshio Ichiwata, Shu Hisata, Hideya Iijima, Toshinori Takada, Hiroki Tsukada, Hideaki Nakayama, Jun-Ichi Machiya, Toshiya Irokawa, Hiromasa Ogawa, Yoko Shibata, Masakazu Ichinose, Masahito Ebina, Toshihiro Nukiwa, Hajime Kurosawa, Koh Nakata, Ryushi Tazawa. Sequential Granulocyte-Macrophage Colony-Stimulating Factor Inhalation after Whole-Lung Lavage for Pulmonary Alveolar Proteinosis. A Report of Five Intractable Cases. Ann Am Thorac Soc. 2017.08; 14 (8): 1298-1304. ( PubMed, DOI )

  21. Masayuki Ito, Kazuyuki Nakagome, Hiromitsu Ohta, Keiichi Akasaka, Yoshitaka Uchida, Atsushi Hashimoto, Ayako Shiono, Toshinori Takada, Makoto Nagata, Jun Tohyama, Koichi Hagiwara, Minoru Kanazawa, Koh Nakata, Ryushi Tazawa. Elderly-onset hereditary pulmonary alveolar proteinosis and its cytokine profile. BMC Pulm Med. 2017.02; 17 (1): 40. ( PubMed, DOI )

  22. Toshinori Takada, Ayako Mikami, Nobutaka Kitamura, Kuniaki Seyama, Yoshikazu Inoue, Katsura Nagai, Masaru Suzuki, Hiroshi Moriyama, Keiichi Akasaka, Ryushi Tazawa, Toyohiro Hirai, Michiaki Mishima, Mie Hayashida, Masaki Hirose, Chikatoshi Sugimoto, Toru Arai, Noboru Hattori, Kentaro Watanabe, Tsutomu Tamada, Hirohisa Yoshizawa, Kohei Akazawa, Takahiro Tanaka, Keita Yagi, Lisa R Young, Francis X McCormack, Koh Nakata. Efficacy and Safety of Long-Term Sirolimus Therapy for Asian Patients with Lymphangioleiomyomatosis. Ann Am Thorac Soc. 2016.11; 13 (11): 1912-1922. ( PubMed, DOI )

  23. Tazawa Ryushi, Nakata Koh. Pulmonary alveolar proteinosis and granulocyte/macrophage-colony stimulating factor (GM-CSF) inhalation Exp. Opin. Orphan Drugs. 2016.01; 4 (1): 115-123. ( DOI )

  24. Keiichi Akasaka, Takahiro Tanaka, Nobutaka Kitamura, Shinya Ohkouchi, Ryushi Tazawa, Toshinori Takada, Toshio Ichiwata, Etsuro Yamaguchi, Masaki Hirose, Toru Arai, Kentaro Nakano, Takahito Nei, Haruyuki Ishii, Tomohiro Handa, Yoshikazu Inoue, Koh Nakata. Outcome of corticosteroid administration in autoimmune pulmonary alveolar proteinosis: a retrospective cohort study. BMC Pulm Med. 2015.08; 15 88. ( PubMed, DOI )

  25. Masato Moriyama, Toshio Yano, Tatsuo Furukawa, Toshinori Takada, Takashi Ushiki, Masayoshi Masuko, Jun Takizawa, Hirohito Sone, Ryushi Tazawa, Yasuo Saijo, Haruyuki Ishii, Koh Nakata. Possible Involvement of Lung Cells Harboring an Abnormal Karyotype in the Pathogenesis of Pulmonary Alveolar Proteinosis Associated with Myelodysplastic Syndrome. Ann Am Thorac Soc. 2015.08; 12 (8): 1251-1253. ( PubMed, DOI )

  26. Keiichi Akasaka, Takahiro Tanaka, Takashi Maruyama, Nobutaka Kitamura, Atsushi Hashimoto, Yuko Ito, Hiroyoshi Watanabe, Tomoshige Wakayama, Takero Arai, Masachika Hayashi, Hiroshi Moriyama, Kanji Uchida, Shinya Ohkouchi, Ryushi Tazawa, Toshinori Takada, Etsuro Yamaguchi, Toshio Ichiwata, Masaki Hirose, Toru Arai, Yoshikazu Inoue, Hirosuke Kobayashi, Koh Nakata. A mathematical model to predict protein wash out kinetics during whole-lung lavage in autoimmune pulmonary alveolar proteinosis. Am. J. Physiol. Lung Cell Mol. Physiol.. 2015.01; 308 (2): L105-L117. ( PubMed, DOI )

  27. Takehiro Serikawa, Kenichi Nishiyama, Jun Tohyama, Ryushi Tazawa, Kiyoe Goto, Yoko Kuriyama, Kazufumi Haino, Yonehiro Kanemura, Mami Yamasaki, Koh Nakata, Koichi Takakuwa, Takayuki Enomoto. Prenatal molecular diagnosis of X-linked hydrocephalus via a silent C924T mutation in the L1CAM gene. Congenit Anom (Kyoto). 2014.11; 54 (4): 243-245. ( PubMed, DOI )

  28. Atsushi Hashimoto, Takahiro Tanaka, Yuko Itoh, Akira Yamagata, Nobutaka Kitamura, Ryushi Tazawa, Kazuhide Nakagaki, Koh Nakata. Low concentrations of recombinant granulocyte macrophage-colony stimulating factor derived from Chinese hamster ovary cells augments long-term bioactivity with delayed clearance in vitro. Cytokine. 2014.08; 68 (2): 118-126. ( PubMed, DOI )

  29. Kazuhide Nakagaki, Yuka Nunomura, Kanji Uchida, Koh Nakata, Ryushi Tazawa. Up-regulation of cluster of differentiation (CD) 11b expression on the surface of canine granulocytes with human granulocyte-macrophage colony-stimulating factor (GM-CSF). J. Vet. Med. Sci.. 2014.08; 76 (8): 1173-1176. ( PubMed, DOI )

  30. Ryushi Tazawa, Yoshikazu Inoue, Toru Arai, Toshinori Takada, Yasunori Kasahara, Masayuki Hojo, Shinya Ohkouchi, Yoshiko Tsuchihashi, Masanori Yokoba, Ryosuke Eda, Hideaki Nakayama, Haruyuki Ishii, Takahito Nei, Konosuke Morimoto, Yasuyuki Nasuhara, Masahito Ebina, Masanori Akira, Toshio Ichiwata, Koichiro Tatsumi, Etsuro Yamaguchi, Koh Nakata. Duration of benefit in patients with autoimmune pulmonary alveolar proteinosis after inhaled granulocyte-macrophage colony-stimulating factor therapy. Chest. 2014.04; 145 (4): 729-737. ( PubMed, DOI )

  31. Haruyuki Ishii, John F Seymour, Ryushi Tazawa, Yoshikazu Inoue, Naoyuki Uchida, Aya Nishida, Yoshihito Kogure, Takeshi Saraya, Keisuke Tomii, Toshinori Takada, Yuko Itoh, Masayuki Hojo, Toshio Ichiwata, Hajime Goto, Koh Nakata. Secondary pulmonary alveolar proteinosis complicating myelodysplastic syndrome results in worsening of prognosis: a retrospective cohort study in Japan. BMC Pulm Med. 2014.03; 14 37. ( PubMed, DOI )

  32. Takahito Nei, Shinya Urano, Yuko Itoh, Nobutaka Kitamura, Atsushi Hashimoto, Takahiro Tanaka, Natsuki Motoi, Chinatsu Kaneko, Ryushi Tazawa, Kazuhide Nakagaki, Toru Arai, Yoshikazu Inoue, Koh Nakata. Light chain (κ/λ) ratio of GM-CSF autoantibodies is associated with disease severity in autoimmune pulmonary alveolar proteinosis. Clin. Immunol.. 2013.12; 149 (3): 357-364. ( PubMed, DOI )

  33. Shu Hisata, Hiroshi Moriyama, Ryushi Tazawa, Shinya Ohkouchi, Masakazu Ichinose, Masahito Ebina. Development of pulmonary alveolar proteinosis following exposure to dust after the Great East Japan Earthquake. Respir Investig. 2013.12; 51 (4): 212-216. ( PubMed, DOI )

  34. Hiroki Maruyama, Takuma Takata, Yutaka Tsubata, Ryushi Tazawa, Kiyoe Goto, Jun Tohyama, Ichiei Narita, Hidekatsu Yoshioka, Satoshi Ishii. Screening of male dialysis patients for fabry disease by plasma globotriaosylsphingosine. Clin J Am Soc Nephrol. 2013.04; 8 (4): 629-636. ( PubMed, DOI )

  35. Won Fen Wong, Kazuyoshi Kohu, Akira Nakamura, Masahito Ebina, Toshiaki Kikuchi, Ryushi Tazawa, Keisuke Tanaka, Shunsuke Kon, Tomo Funaki, Akiko Sugahara-Tobinai, Chung Yeng Looi, Shota Endo, Ryo Funayama, Mineo Kurokawa, Sonoko Habu, Naoto Ishii, Manabu Fukumoto, Koh Nakata, Toshiyuki Takai, Masanobu Satake. Runx1 deficiency in CD4+ T cells causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells. J. Immunol.. 2012.06; 188 (11): 5408-5420. ( PubMed, DOI )

  36. Takahito Nei, Shinya Urano, Natsuki Motoi, Jun Takizawa, Chinatsu Kaneko, Hiroko Kanazawa, Ryushi Tazawa, Kazuhide Nakagaki, Kiyoko S Akagawa, Keiichi Akasaka, Toshio Ichiwata, Arata Azuma, Koh Nakata. IgM-type GM-CSF autoantibody is etiologically a bystander but associated with IgG-type autoantibody production in autoimmune pulmonary alveolar proteinosis. Am. J. Physiol. Lung Cell Mol. Physiol.. 2012.05; 302 (9): L959-L964. ( PubMed, DOI )

  37. K Ohashi, A Sato, T Takada, T Arai, Y Kasahara, M Hojo, T Nei, H Nakayama, N Motoi, S Urano, R Eda, M Yokoba, Y Tsuchihashi, Y Nasuhara, H Ishii, M Ebina, E Yamaguchi, Y Inoue, K Nakata, R Tazawa. Reduced GM-CSF autoantibody in improved lung of autoimmune pulmonary alveolar proteinosis. Eur. Respir. J.. 2012.03; 39 (3): 777-780. ( PubMed, DOI )

  38. Kazumasa Ohashi, Atsuyasu Sato, Toshinori Takada, Toru Arai, Takahito Nei, Yasunori Kasahara, Natsuki Motoi, Masayuki Hojo, Shinya Urano, Haruyuki Ishii, Masanori Yokoba, Ryosuke Eda, Hideaki Nakayama, Yasuyuki Nasuhara, Yoshiko Tsuchihashi, Chinatsu Kaneko, Hiroko Kanazawa, Masahito Ebina, Etsuro Yamaguchi, Jacqueline Kirchner, Yoshikazu Inoue, Koh Nakata, Ryushi Tazawa. Direct evidence that GM-CSF inhalation improves lung clearance in pulmonary alveolar proteinosis. Respir Med. 2012.02; 106 (2): 284-293. ( PubMed, DOI )

  39. Hironori Satoh, Ryushi Tazawa, Tomohiro Sakakibara, Shinya Ohkouchi, Masahito Ebina, Makoto Miki, Koh Nakata, Toshihiro Nukiwa. Bilateral peripheral infiltrates refractory to immunosuppressants were diagnosed as autoimmune pulmonary alveolar proteinosis and improved by inhalation of granulocyte/macrophage-colony stimulating factor. Intern. Med.. 2012; 51 (13): 1737-1742. ( PubMed, DOI )

  40. Shinya Urano, Ryushi Tazawa, Takahito Nei, Natsuki Motoi, Masato Watanabe, Takenori Igarashi, Masahiro Tomita, Koh Nakata. A cell free assay system estimating the neutralizing capacity of GM-CSF antibody using recombinant soluble GM-CSF receptor. J Vis Exp. 2011.06; (52): ( PubMed, DOI )

  41. Takeshi Tanaka, Natsuki Motoi, Yoshiko Tsuchihashi, Ryushi Tazawa, Chinatsu Kaneko, Takahito Nei, Toshiyuki Yamamoto, Tomayoshi Hayashi, Tsutomu Tagawa, Takeshi Nagayasu, Futoshi Kuribayashi, Koya Ariyoshi, Koh Nakata, Konosuke Morimoto. Adult-onset hereditary pulmonary alveolar proteinosis caused by a single-base deletion in CSF2RB. J. Med. Genet.. 2011.03; 48 (3): 205-209. ( PubMed, DOI )

  42. H Ishii, R Tazawa, C Kaneko, T Saraya, Y Inoue, E Hamano, Y Kogure, K Tomii, M Terada, T Takada, M Hojo, A Nishida, T Ichiwata, B C Trapnell, H Goto, K Nakata. Clinical features of secondary pulmonary alveolar proteinosis: pre-mortem cases in Japan. Eur. Respir. J.. 2011.02; 37 (2): 465-468. ( PubMed, DOI )

  43. Shinya Urano, Chinatsu Kaneko, Takahito Nei, Natsuki Motoi, Ryushi Tazawa, Masato Watanabe, Masahiro Tomita, Takahiro Adachi, Hiroko Kanazawa, Koh Nakata. A cell-free assay to estimate the neutralizing capacity of granulocyte-macrophage colony-stimulating factor autoantibodies. J. Immunol. Methods. 2010.08; 360 (1-2): 141-148. ( PubMed, DOI )

  44. Ryushi Tazawa, Bruce C Trapnell, Yoshikazu Inoue, Toru Arai, Toshinori Takada, Yasuyuki Nasuhara, Nobuyuki Hizawa, Yasunori Kasahara, Koichiro Tatsumi, Masayuki Hojo, Haruyuki Ishii, Masanori Yokoba, Naohiko Tanaka, Etsuro Yamaguchi, Ryosuke Eda, Yoshiko Tsuchihashi, Konosuke Morimoto, Masanori Akira, Masaki Terada, Junji Otsuka, Masahito Ebina, Chinatsu Kaneko, Toshihiro Nukiwa, Jeffrey P Krischer, Kohei Akazawa, Koh Nakata. Inhaled granulocyte/macrophage-colony stimulating factor as therapy for pulmonary alveolar proteinosis. Am. J. Respir. Crit. Care Med.. 2010.06; 181 (12): 1345-1354. ( PubMed, DOI )

  45. Haruyuki Ishii, Bruce C Trapnell, Ryushi Tazawa, Yoshikazu Inoue, Masanori Akira, Yoshihito Kogure, Keisuke Tomii, Toshinori Takada, Masayuki Hojo, Toshio Ichiwata, Hajime Goto, Koh Nakata, . Comparative study of high-resolution CT findings between autoimmune and secondary pulmonary alveolar proteinosis. Chest. 2009.11; 136 (5): 1348-1355. ( PubMed, DOI )

  46. T Kikuchi, A Watanabe, K Gomi, T Sakakibara, K Nishimori, H Daito, S Fujimura, R Tazawa, A Inoue, M Ebina, Y Tokue, M Kaku, T Nukiwa. Association between mycobacterial genotypes and disease progression in Mycobacterium avium pulmonary infection. Thorax. 2009.10; 64 (10): 901-907. ( PubMed, DOI )

  47. Yoshikazu Inoue, Bruce C Trapnell, Ryushi Tazawa, Toru Arai, Toshinori Takada, Nobuyuki Hizawa, Yasunori Kasahara, Koichiro Tatsumi, Masaaki Hojo, Toshio Ichiwata, Naohiko Tanaka, Etsuro Yamaguchi, Ryosuke Eda, Kazunori Oishi, Yoshiko Tsuchihashi, Chinatsu Kaneko, Toshihiro Nukiwa, Mitsunori Sakatani, Jeffrey P Krischer, Koh Nakata, . Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan. Am. J. Respir. Crit. Care Med.. 2008.04; 177 (7): 752-762. ( PubMed, DOI )

  48. Huqun, Shinyu Izumi, Hitoshi Miyazawa, Kuniaki Ishii, Bine Uchiyama, Tadashi Ishida, Sawako Tanaka, Ryushi Tazawa, Shunichiro Fukuyama, Tomoaki Tanaka, Yoshiaki Nagai, Akemi Yokote, Hiroki Takahashi, Toshihiko Fukushima, Kunihiko Kobayashi, Hirofumi Chiba, Makoto Nagata, Susumu Sakamoto, Koichiro Nakata, Yuji Takebayashi, Yoshihiko Shimizu, Koichi Kaneko, Michio Shimizu, Minoru Kanazawa, Shosaku Abe, Yoshikazu Inoue, Seiichi Takenoshita, Kunihiko Yoshimura, Koichiro Kudo, Teruo Tachibana, Toshihiro Nukiwa, Koichi Hagiwara. Mutations in the SLC34A2 gene are associated with pulmonary alveolar microlithiasis. Am. J. Respir. Crit. Care Med.. 2007.02; 175 (3): 263-268. ( PubMed, DOI )

  49. Yoshikazu Inoue, Koh Nakata, Toru Arai, Ryushi Tazawa, Emi Hamano, Toshihiro Nukiwa, Koichiro Kudo, Naoto Keicho, Nobuyuki Hizawa, Etsuro Yamaguchi, Ryosuke Eda, Kazunori Oishi, Yuuka Maeda, Yukiko Koreeda, Naohiko Kodo, Mitsunori Sakatani. Epidemiological and clinical features of idiopathic pulmonary alveolar proteinosis in Japan. Respirology. 2006.01; 11 Suppl S55-S60. ( PubMed, DOI )

  50. Ryushi Tazawa, Koh Nakata, Yoshikazu Inoue, Toshihiro Nukiwa. Granulocyte-macrophage colony-stimulating factor inhalation therapy for patients with idiopathic pulmonary alveolar proteinosis: a pilot study; and long-term treatment with aerosolized granulocyte-macrophage colony-stimulating factor: a case report. Respirology. 2006.01; 11 Suppl S61-S64. ( PubMed, DOI )

  51. Hiromitsu Ohta, Ryushi Tazawa, Atsushi Nakamura, Yuichiro Kimura, Makoto Maemondo, Toshiaki Kikuchi, Masahito Ebina, Toshihiro Nukiwa. Acute-onset sarcoidosis with erythema nodosum and polyarthralgia (Löfgren's syndrome) in Japan: a case report and a review of the literature. Intern. Med.. 2006; 45 (9): 659-662. ( PubMed, DOI )

  52. Ryushi Tazawa, Emi Hamano, Toru Arai, Hiromitsu Ohta, Osamu Ishimoto, Kanji Uchida, Masato Watanabe, Junichi Saito, Miki Takeshita, Yasuhiko Hirabayashi, Ikuo Ishige, Yoshinobu Eishi, Koichi Hagiwara, Masahito Ebina, Yoshikazu Inoue, Koh Nakata, Toshihiro Nukiwa. Granulocyte-macrophage colony-stimulating factor and lung immunity in pulmonary alveolar proteinosis. Am. J. Respir. Crit. Care Med.. 2005.05; 171 (10): 1142-1149. ( PubMed, DOI )

  53. Takuji Suzuki, Tatsuro Fukuhara, Masashi Tanaka, Akira Nakamura, Kenichi Akiyama, Tomohiro Sakakibara, Daizo Koinuma, Toshiaki Kikuchi, Ryushi Tazawa, Makoto Maemondo, Koichi Hagiwara, Yasuo Saijo, Toshihiro Nukiwa. Vaccination of dendritic cells loaded with interleukin-12-secreting cancer cells augments in vivo antitumor immunity: characteristics of syngeneic and allogeneic antigen-presenting cell cancer hybrid cells. Clin. Cancer Res.. 2005.01; 11 (1): 58-66. ( PubMed )

  54. Toru Arai, Emi Hamano, Yoshikazu Inoue, Tazawa Ryushi, Toshihiro Nukiwa, Mitsunori Sakatani, Koh Nakata. Serum neutralizing capacity of GM-CSF reflects disease severity in a patient with pulmonary alveolar proteinosis successfully treated with inhaled GM-CSF. Respir Med. 2004.12; 98 (12): 1227-1230. ( PubMed )

  55. Makoto Maemondo, Yasuo Saijo, Ko Narumi, Toshiaki Kikuchi, Kazuhiro Usui, Ryushi Tazawa, Kunio Matsumoto, Toshikazu Nakamura, Katsunori Sasaki, Minoru Takahashi, Yoshiro Niitsu, Toshihiro Nukiwa. Gene therapy with secretory leukoprotease inhibitor promoter-controlled replication-competent adenovirus for non-small cell lung cancer. Cancer Res.. 2004.07; 64 (13): 4611-4620. ( PubMed, DOI )

  56. Akira Saito, Hajime Takizawa, Makoto Sato, Kenji Suzuki, Tadayuki Miyata, Tatsuyuki Tazawa, Toshihiro Nukiwa, Yutaka Morita. Alpha-1 antitrypsin deficiency with severe pulmonary emphysema. Intern. Med.. 2004.03; 43 (3): 223-226. ( PubMed, DOI )

  57. Kazuhiro Usui, Yasuo Saijo, Ko Narumi, Shohei Koyama, Makoto Maemondo, Toshiaki Kikuchi, Ryushi Tazawa, Koichi Hagiwara, Yoshitomo Ishibashi, Shigeo Ohta, Toshihiro Nukiwa. N-terminal deletion augments the cell-death-inducing activity of BAX in adenoviral gene delivery to nonsmall cell lung cancers. Oncogene. 2003.05; 22 (17): 2655-2663. ( PubMed, DOI )

  58. Yasuo Saijo, Masashi Tanaka, Makoto Miki, Kazuhiro Usui, Takuji Suzuki, Makoto Maemondo, Xin Hong, Ryushi Tazawa, Toshiaki Kikuchi, Kouji Matsushima, Toshihiro Nukiwa. Proinflammatory cytokine IL-1 beta promotes tumor growth of Lewis lung carcinoma by induction of angiogenic factors: in vivo analysis of tumor-stromal interaction. J. Immunol.. 2002.07; 169 (1): 469-475. ( PubMed, DOI )

  59. Makoto Maemondo, Ko Narumi, Yasuo Saijo, Kazuhiro Usui, Minoru Tahara, Ryushi Tazawa, Koichi Hagiwara, Kunio Matsumoto, Toshikazu Nakamura, Toshihiro Nukiwa. Targeting angiogenesis and HGF function using an adenoviral vector expressing the HGF antagonist NK4 for cancer therapy. Mol. Ther.. 2002.02; 5 (2): 177-185. ( PubMed, DOI )

  60. Prasenohadi Pradono, Ryushi Tazawa, Makoto Maemondo, Masashi Tanaka, Kazuhiro Usui, Yasuo Saijo, Koichi Hagiwara, Toshihiro Nukiwa. Gene transfer of thromboxane A(2) synthase and prostaglandin I(2) synthase antithetically altered tumor angiogenesis and tumor growth. Cancer Res.. 2002.01; 62 (1): 63-66. ( PubMed )

  61. K Usui, Y Sasahara, R Tazawa, K Hagiwara, S Tsukada, T Miyawaki, S Tsuchiya, T Nukiwa. Recurrent pneumonia with mild hypogammaglobulinemia diagnosed as X-linked agammaglobulinemia in adults. Respir. Res.. 2001; 2 (3): 188-192. ( PubMed )

  62. M Tanaka, Y Saijo, G Sato, T Suzuki, R Tazawa, K Satoh, T Nukiwa. Induction of antitumor immunity by combined immunogene therapy using IL-2 and IL-12 in low antigenic Lewis lung carcinoma. Cancer Gene Ther.. 2000.11; 7 (11): 1481-1490. ( PubMed, DOI )

  63. Y Saijo, X Hong, M Tanaka, R Tazawa, S Q Liu, K Saijo, T Ohno, K Koike, K Ohkuda, K Satoh, T Nukiwa. Autologous high-killing cytotoxic T lymphocytes against human lung cancer are induced using interleukin (IL)-1beta, IL-2, IL-4, and IL-6: possible involvement of dendritic cells. Clin. Cancer Res.. 1999.05; 5 (5): 1203-1209. ( PubMed )

  64. R Tazawa, E D Green, K Ohashi, K K Wu, L H Wang. Characterization of the complete genomic structure of human thromboxane synthase gene and functional analysis of its promoter. Arch. Biochem. Biophys.. 1996.10; 334 (2): 349-356. ( PubMed, DOI )

  65. X M Xu, A Hajibeige, R Tazawa, D Loose-Mitchell, L H Wang, K K Wu. Characterization of human prostaglandin H synthase genes. Adv. Prostaglandin Thromboxane Leukot. Res.. 1995; 23 105-107. ( PubMed )

  66. L H Wang, R Tazawa, A Q Lang, K K Wu. Alternate splicing of human thromboxane synthase mRNA. Arch. Biochem. Biophys.. 1994.12; 315 (2): 273-278. ( PubMed, DOI )

  67. R Tazawa, X M Xu, K K Wu, L H Wang. Characterization of the genomic structure, chromosomal location and promoter of human prostaglandin H synthase-2 gene. Biochem. Biophys. Res. Commun.. 1994.08; 203 (1): 190-199. ( PubMed, DOI )

  68. R Tazawa, K Yamamoto, K Suzuki, K Hirokawa, S Hirosawa, N Aoki. Presence of functional cyclic AMP responsive element in the 3'-untranslated region of the human thrombomodulin gene. Biochem. Biophys. Res. Commun.. 1994.05; 200 (3): 1391-1397. ( PubMed, DOI )

  69. R Tazawa, S Hirosawa, K Suzuki, K Hirokawa, N Aoki. Functional characterization of the 5'-regulatory region of the human thrombomodulin gene. J. Biochem.. 1993.05; 113 (5): 600-606. ( PubMed, DOI )

  70. S Miyake, S Ohdama, R Tazawa, N Aoki. Retinoic acid prevents cytokine-induced suppression of thrombomodulin expression on surface of human umbilical vascular endothelial cells in vitro. Thromb. Res.. 1992.12; 68 (6): 483-487. ( PubMed )

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Books etc 【 display / non-display 】

  1. Nakata K, Tazawa R. Treatment of Cystic Fibrosis and Other Rare Lung Diseases (Milestones in Drug Therapy) Azuma A, Schechters MS, Ed.. Springer， 2017 Chapter 4. Pulmonary Alveolar Proteinosis: A Historic Perspective.

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Conference Activities & Talks 【 display / non-display 】

  1. Koh Nakata, Ryushi Tazawa, Page Research Group, Nobutaka Kitamura, Haruyuki Ishii. Two-year cohort study after GM-CSF inhalation therapy for autoimmune pulmonary alveolar proteinosi. The 2023 ERS International Congress 2023.09 Milan, Italy

  2. R. Tazawa, T. Ueda, M. Abe, K. Tatsumi, R. Eda, S. Kondoh, K. Morimoto, T. Tanaka, E. Yamaguchi, A. Takahashi, M. Oda, H. Ishii, S. Izumi, H. Sugiyama, A. Nakagawa, K. Tomii, M. Suzuki, S. Konno, S. Ohkouchi, N. Tode, T. Handa, T. Hirai, Y. Inoue, T. Arai, K. Asakawa, T. Sakagami, A. Hashimoto, T. Tanaka, T. Takada, A. Mikami, N. Kitamura, K. Nakata. Antibody Against Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) and Inhaled GM-CSF for Pulmonary Alveolar Proteinosis. ATS 2020 Virtual American Thoracic Society International Conference 2020.08.05

  3. Ryushi Tazawa. Meet the Professor Seminar. MP601. Inhalation of Recombinant Human Granulocyte-Colony Stimulating Factor and Autoimmune Pulmonary Alveolar Proteinosis. ATS 2019 American Thoracic Society International Conference 2019.05.21 Dallas, TX, USA

  4. R. Tazawa, K. Nakagaki, Y. Ito, M. Iizuka, A. Hashimoto, R. Nakano, U. Seino, T. Tanaka, K. Akasaka, S. Takeuchi, K. Nakata. Induction of Antibody against Granulocyte/Macrophage Colony Stimulating Factor (GM-CSF) through Repeated Inhalation of Recombinant Human GM-CSF in No Human Primates. ATS 2018 American Thoracic Society International Conference 2018.05.22 San Diego, CA, USA

  5. R. Tazawa, K. Nakagaki, Y. Ito, M. Iizuka, A. Hashimoto, R. Nakano, T. Tanaka, K. Akasaka, S. Takeuchi, K. Nakata. Chronic Inhalation of Recombinant Human Granulocyte/Macrophage Colony Stimulating Factor (GM-CSF) and GM-CSF Antibody in Nonhuman Primates. ATS 2017 American Thoracic Society International Conference 2017.05.23 Washington, D.C., USA

  6. R. Tazawa, M. Ito, K. Nakagome, K. Akasaka, H. Ohta , Y. Uchida, A. Shiono, T. Takada, M. Nagata, J. Tohyama, K. Hagiwara, M. Kanazawa, K. Nakata . Elderly-Onset Hereditary Pulmonary Alveolar Proteinosis and CSF2RA Mutation. ATS 2016 American Thoracic Society International Conference 2016.05.16 San Francisco, CA, USA

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Awards & Honors 【 display / non-display 】

  • Young Investigator's Award of the Japanese Society of Internal Medicine，The Japanese Society of Internal Medicine，2004.04

  • Academic Award of Niigata Medical Association，Niigata Medical Association，2016.11

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