Personnel Information

写真a

KOCHI Yuta


Job title

Professor

Graduating School 【 display / non-display

  • The University of Tokyo, Faculty of Medicine, 1999.03, Graduated

Graduate School 【 display / non-display

  • The University of Tokyo, Graduate School, Division of Medical Sciences, Doctor's Course, 2005.03, Completed

Campus Career 【 display / non-display

  • 2019.06
    -
    2022.04
    Tokyo Medical and Dental University, Medical Research Institute, Medical Genomics, Department of Genomic Function and Diversity, Professor
  • 2022.05
    -
    2024.09
    Tokyo Medical and Dental University, Medical Research Institute, Division of Biological Data Science, Department of Genomic Function and Diversity, Professor
  • 2024.10
    -
    Now
    Institute of Science Tokyo, -, Institute of Integrated Research, Biological Data Science, Genomic Function and Diversity, Professor

External Career 【 display / non-display

  • 1999.06
    -
    2000.05
    , Trainee Resident
  • 2000.06
    -
    2001.05
    , Trainee Resident
  • 2001.04
    -
    2005.03
    , Graduate Student

Research Areas 【 display / non-display

  • System genome science

  • Connective tissue disease and allergy

  • Medical biochemistry

 

Published Papers & Misc 【 display / non-display

  1. Ono Chisato, Kochi Yuta, Baba Yoshihiro, Tanaka Shinya. B細胞におけるFcrl5過剰発現によるB細胞の生存性促進により液性免疫反応は増強される(Humoral responses are enhanced by facilitating B cell viability by Fcrl5 overexpression in B cells) International Immunology. 2024.10; 36 (10): 529-539. ( ichushi )

  2. Ueda MT, Inamo J, Miya F, Shimada M, Yamaguchi K, Kochi Y. Functional and dynamic profiling of transcript isoforms reveals essential roles of alternative splicing in interferon response. Cell genomics. 2024.10; 4 (10): 100654. ( PubMed, DOI )

  3. Izuka S, Umezawa N, Komai T, Sugimori Y, Kimura N, Mizoguchi F, Fujieda Y, Ninagawa K, Iwasaki T, Suzuki K, Takeuchi T, Ohmura K, Mimori T, Atsumi T, Kawakami E, Suzuki A, Kochi Y, Yamamoto K, Yasuda S, Okamura T, Ota M, Fujio K. The muscle tissue transcriptome of idiopathic inflammatory myopathy reflects the muscle damage process by monocytes and presence of skin lesions. Arthritis & rheumatology (Hoboken, N.J.). 2024.08; 77 (1): 99-106. ( PubMed, DOI )

  4. Inamo J, Suzuki A, Ueda MT, Yamaguchi K, Nishida H, Suzuki K, Kaneko Y, Takeuchi T, Hatano H, Ishigaki K, Ishihama Y, Yamamoto K, Kochi Y. Long-read sequencing for 29 immune cell subsets reveals disease-linked isoforms. Nature communications. 2024.05; 15 (1): 4285. ( PubMed, DOI )

  5. Ono C, Kochi Y, Baba Y, Tanaka S. Humoral responses are enhanced by facilitating B cell viability by Fcrl5 overexpression in B cells. International immunology. 2024.05; 36 (10): 529-540. ( PubMed, DOI )

  6. Okunishi K, Kochi Y, Zhao M, Wang H, Nakagome K, Izumi T. Munc13-4 regulates asthma and obesity in mice by controlling functions of CD11c(+) antigen-presenting cells. Allergy. 2024.03; 79 (7): 1992-1995. ( PubMed, DOI )

  7. Fuseya Y, Kadoba K, Liu X, Suetsugu H, Iwasaki T, Ohmura K, Sumida T, Kochi Y, Morinobu A, Terao C, Iwai K. Attenuation of HOIL-1L ligase activity promotes systemic autoimmune disorders by augmenting linear ubiquitin signaling. JCI insight. 2024.02; 9 (3): ( PubMed, DOI )

  8. Chang S, Torii S, Inamo J, Ishikawa K, Kochi Y, Shimizu S. Uncovering the Localization and Function of a Novel Read-Through Transcript 'TOMM40-APOE'. Cells. 2023.12; 13 (1): ( PubMed, DOI )

  9. Mitsui Y, Suzuki T, Kuniyoshi K, Inamo J, Yamaguchi K, Komuro M, Watanabe J, Edamoto M, Li S, Kouno T, Oba S, Hosoya T, Masuhiro K, Naito Y, Koyama S, Sakaguchi N, Standley DM, Shin JW, Akira S, Yasuda S, Miyazaki Y, Kochi Y, Kumanogoh A, Okamoto T, Satoh T. Expression of the readthrough transcript CiDRE in alveolar macrophages boosts SARS-CoV-2 susceptibility and promotes COVID-19 severity. Immunity. 2023.08; 56 (8): 1939-1954.e12. ( PubMed, DOI )

  10. Nao Otomo, Anas M Khanshour, Masaru Koido, Kazuki Takeda, Yukihide Momozawa, Michiaki Kubo, Yoichiro Kamatani, John A Herring, Yoji Ogura, Yohei Takahashi, Shohei Minami, Koki Uno, Noriaki Kawakami, Manabu Ito, Tatsuya Sato, Kei Watanabe, Takashi Kaito, Haruhisa Yanagida, Hiroshi Taneichi, Katsumi Harimaya, Yuki Taniguchi, Hideki Shigematsu, Takahiro Iida, Satoru Demura, Ryo Sugawara, Nobuyuki Fujita, Mitsuru Yagi, Eijiro Okada, Naobumi Hosogane, Katsuki Kono, Masaya Nakamura, Kazuhiro Chiba, Toshiaki Kotani, Tsuyoshi Sakuma, Tsutomu Akazawa, Teppei Suzuki, Kotaro Nishida, Kenichiro Kakutani, Taichi Tsuji, Hideki Sudo, Akira Iwata, Satoshi Inami, Carol A Wise, Yuta Kochi, Morio Matsumoto, Shiro Ikegawa, Kota Watanabe, Chikashi Terao. Evidence of causality of low body mass index on risk of adolescent idiopathic scoliosis: a Mendelian randomization study. Front Endocrinol (Lausanne). 2023.06; 14 1089414. ( PubMed, DOI )

  11. Fujitani H, Eguchi H, Kochi Y, Arai T, Muramatsu M, Okazaki Y. Rare germline variants in pancreatic cancer and multiple primary cancers: an autopsy study. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 2023.05; 32 (3): 286-297. ( PubMed, DOI )

  12. Ono C, Tanaka S, Myouzen K, Iwasaki T, Ueda M, Oda Y, Yamamoto K, Kochi Y, Baba Y. Upregulated Fcrl5 disrupts B cell anergy causes autoimmune disease. Frontiers in immunology. 2023; 14 1276014. ( PubMed, DOI )

  13. Kato Daiki, Mitsuhashi Satomi, Miya Fuyuki, Saitoh Shinji, Okamoto Nobuhiko, Tsunoda Tatsuhiko, Kochi Yuta. Mendel遺伝病における遺伝子の優先順位付けに、組織特異的遺伝子発現スコアの有用性(Utility of tissue-specific gene expression scores for gene prioritization in Mendelian diseases) Journal of Human Genetics. 2022.12; 67 (12): 739-742. ( ichushi )

  14. Ishigaki K, Sakaue S, Terao C, Luo Y, Sonehara K, Yamaguchi K, Amariuta T, Too CL, Laufer VA, Scott IC, Viatte S, Takahashi M, Ohmura K, Murasawa A, Hashimoto M, Ito H, Hammoudeh M, Emadi SA, Masri BK, Halabi H, Badsha H, Uthman IW, Wu X, Lin L, Li T, Plant D, Barton A, Orozco G, Verstappen SMM, Bowes J, MacGregor AJ, Honda S, Koido M, Tomizuka K, Kamatani Y, Tanaka H, Tanaka E, Suzuki A, Maeda Y, Yamamoto K, Miyawaki S, Xie G, Zhang J, Amos CI, Keystone E, Wolbink G, van der Horst-Bruinsma I, Cui J, Liao KP, Carroll RJ, Lee HS, Bang SY, Siminovitch KA, de Vries N, Alfredsson L, Rantapää-Dahlqvist S, Karlson EW, Bae SC, Kimberly RP, Edberg JC, Mariette X, Huizinga T, Dieudé P, Schneider M, Kerick M, Denny JC, BioBank Japan Project, Matsuda K, Matsuo K, Mimori T, Matsuda F, Fujio K, Tanaka Y, Kumanogoh A, Traylor M, Lewis CM, Eyre S, Xu H, Saxena R, Arayssi T, Kochi Y, Ikari K, Harigai M, Gregersen PK, Yamamoto K, Louis Bridges S Jr, Padyukov L, Martin J, Klareskog L, Okada Y, Raychaudhuri S. Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis. Nature genetics. 2022.11; 54 (11): 1640-1651. ( PubMed, DOI )

  15. Yamaguchi K, Ishigaki K, Suzuki A, Tsuchida Y, Tsuchiya H, Sumitomo S, Nagafuchi Y, Miya F, Tsunoda T, Shoda H, Fujio K, Yamamoto K, Kochi Y. Splicing QTL analysis focusing on coding sequences reveals mechanisms for disease susceptibility loci. Nature communications. 2022.08; 13 (1): 4659. ( PubMed, DOI )

  16. Kato D, Mitsuhashi S, Miya F, Saitoh S, Okamoto N, Tsunoda T, Kochi Y. Utility of tissue-specific gene expression scores for gene prioritization in Mendelian diseases. Journal of human genetics. 2022.08; 67 (12): 739-742. ( PubMed, DOI )

  17. Scofield RH, Lewis VM, Cavitt J, Kurien BT, Assassi S, Martin J, Gorlova O, Gregersen P, Lee A, Rider LG, O'Hanlon T, Rothwell S, Lilleker J, Myositis Genetics Consortium, Xiaoxi Liu., Kochi Y, Terao C, Igoe A, Stevens W, Sahhar J, Roddy J, Rischmueller M, Lester S, Proudman S, Chen S, Brown MA, Mayes MD, Lamb JA, Miller FW. 47XXY and 47XXX in Scleroderma and Myositis. ACR open rheumatology. 2022.06; 4 (6): 528-533. ( PubMed, DOI )

  18. Iwasaki Y, Takeshima Y, Nakano M, Okubo M, Ota M, Suzuki A, Kochi Y, Okamura T, Endo T, Miki I, Sakurada K, Yamamoto K, Fujio K. Combined plasma metabolomic and transcriptomic analysis identify histidine as a biomarker and potential contributor in SLE pathogenesis. Rheumatology (Oxford, England). 2022.06; 62 (2): 905-913. ( PubMed, DOI )

  19. Yin X, Kim K, Suetsugu H, Bang SY, Wen L, Koido M, Ha E, Liu L, Sakamoto Y, Jo S, Leng RX, Otomo N, Kwon YC, Sheng Y, Sugano N, Hwang MY, Li W, Mukai M, Yoon K, Cai M, Ishigaki K, Chung WT, Huang H, Takahashi D, Lee SS, Wang M, Karino K, Shim SC, Zheng X, Miyamura T, Kang YM, Ye D, Nakamura J, Suh CH, Tang Y, Motomura G, Park YB, Ding H, Kuroda T, Choe JY, Li C, Niiro H, Park Y, Shen C, Miyamoto T, Ahn GY, Fei W, Takeuchi T, Shin JM, Li K, Kawaguchi Y, Lee YK, Wang YF, Amano K, Park DJ, Yang W, Tada Y, Lau YL, Yamaji K, Zhu Z, Shimizu M, Atsumi T, Suzuki A, Sumida T, Okada Y, Matsuda K, Matsuo K, Kochi Y, Japanese Research Committee on Idiopathic Osteonecrosis of the Femoral Head., Yamamoto K, Ohmura K, Kim TH, Yang S, Yamamoto T, Kim BJ, Shen N, Ikegawa S, Lee HS, Zhang X, Terao C, Cui Y, Bae SC. Biological insights into systemic lupus erythematosus through an immune cell-specific transcriptome-wide association study. Annals of the rheumatic diseases. 2022.05; 81 (9): 1273-80. ( PubMed, DOI )

  20. Takeshima Y, Iwasaki Y, Nakano M, Narushima Y, Ota M, Nagafuchi Y, Sumitomo S, Okamura T, Elkon K, Ishigaki K, Suzuki A, Kochi Y, Yamamoto K, Fujio K. Immune cell multiomics analysis reveals contribution of oxidative phosphorylation to B-cell functions and organ damage of lupus. Annals of the rheumatic diseases. 2022.03; 81 (6): 845-853. ( PubMed, DOI )

  21. Honda S, Ikari K, Yano K, Terao C, Tanaka E, Harigai M, Kochi Y. Polygenic risk scores are associated with radiographic progression in patients with rheumatoid arthritis. Arthritis & rheumatology (Hoboken, N.J.). 2022.01; 74 (5): 791-800. ( PubMed, DOI )

  22. Suetsugu H, Kim K, Yamamoto T, Bang SY, Sakamoto Y, Shin JM, Sugano N, Kim JS, Mukai M, Lee YK, Ohmura K, Park DJ, Takahashi D, Ahn GY, Karino K, Kwon YC, Miyamura T, Kim J, Nakamura J, Motomura G, Kuroda T, Niiro H, Miyamoto T, Takeuchi T, Ikari K, Amano K, Tada Y, Yamaji K, Shimizu M, Atsumi T, Seki T, Tanaka Y, Kubo T, Hisada R, Yoshioka T, Yamazaki M, Kabata T, Kajino T, Ohta Y, Okawa T, Naito Y, Kaneuji A, Yasunaga Y, Ohzono K, Tomizuka K, Koido M, Matsuda K, Okada Y, Suzuki A, Kim BJ, Kochi Y, Lee HS, Ikegawa S, Bae SC, Terao C. Novel susceptibility loci for steroid-associated osteonecrosis of the femoral head in systemic lupus erythematosus. Human molecular genetics. 2021.12; 31 (7): 1082-1095. ( PubMed, DOI )

  23. Otomo N, Lu HF, Koido M, Kou I, Takeda K, Momozawa Y, Kubo M, Kamatani Y, Ogura Y, Takahashi Y, Nakajima M, Minami S, Uno K, Kawakami N, Ito M, Sato T, Watanabe K, Kaito T, Yanagida H, Taneichi H, Harimaya K, Taniguchi Y, Shigematsu H, Iida T, Demura S, Sugawara R, Fujita N, Yagi M, Okada E, Hosogane N, Kono K, Nakamura M, Chiba K, Kotani T, Sakuma T, Akazawa T, Suzuki T, Nishida K, Kakutani K, Tsuji T, Sudo H, Iwata A, Kaneko K, Inami S, Kochi Y, Chang WC, Matsumoto M, Watanabe K, Ikegawa S, Terao C. Polygenic Risk Score of Adolescent Idiopathic Scoliosis for Potential Clinical Use. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2021.08; 36 (8): 1481-1491. ( PubMed, DOI )

  24. Tsuji H, Ohmura K, Jin H, Naito R, Arase N, Kohyama M, Suenaga T, Sakakibara S, Kochi Y, Okada Y, Yamamoto K, Kikutani H, Morinobu A, Mimori T, Arase H. Anti-dsDNA antibodies recognize DNA presented on HLA class II molecules of systemic lupus erythematosus risk alleles. Arthritis & rheumatology (Hoboken, N.J.). 2021.06; 74 (1): 105-111. ( PubMed, DOI )

  25. Tanaka N, Koido M, Suzuki A, Otomo N, Suetsugu H, Kochi Y, Tomizuka K, Momozawa Y, Kamatani Y, Biobank Japan Project., Ikegawa S, Yamamoto K, Terao C. Eight novel susceptibility loci and putative causal variants in atopic dermatitis. The Journal of allergy and clinical immunology. 2021.06; 148 (5): 1293-1306. ( PubMed, DOI )

  26. Ota M, Nagafuchi Y, Hatano H, Ishigaki K, Terao C, Takeshima Y, Yanaoka H, Kobayashi S, Okubo M, Shirai H, Sugimori Y, Maeda J, Nakano M, Yamada S, Yoshida R, Tsuchiya H, Tsuchida Y, Akizuki S, Yoshifuji H, Ohmura K, Mimori T, Yoshida K, Kurosaka D, Okada M, Setoguchi K, Kaneko H, Ban N, Yabuki N, Matsuki K, Mutoh H, Oyama S, Okazaki M, Tsunoda H, Iwasaki Y, Sumitomo S, Shoda H, Kochi Y, Okada Y, Yamamoto K, Okamura T, Fujio K. Dynamic landscape of immune cell-specific gene regulation in immune-mediated diseases. Cell. 2021.05; 184 (11): 3006-3021.e17. ( PubMed, DOI )

  27. Matsuzawa Ayumi, Lee Jiyoung, Nakagawa So, Itoh Johbu, Takahashi Ueda Mahoko, Mitsuhashi Satomi, Kochi Yuta, Kaneko-Ishino Tomoko, Ishino Fumitoshi. HERV-Derived Ervpb1 Is Conserved in Simiiformes, Exhibiting Expression in Hematopoietic Cell Lineages Including Macrophages INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021.05; 22 (9): ( PubMed, DOI )

  28. Singh B, Maiti GP, Zhou X, Fazel-Najafabadi M, Bae SC, Sun C, Terao C, Okada Y, Chua KH, Kochi Y, Guthridge JM, Zhang H, Weirauch M, James JA, Harley JB, Varshney GK, Looger LL, Nath SK. Lupus susceptibility region containing CDKN1B rs34330 mechanistically influences expression and function of multiple target genes, also linked to proliferation and apoptosis. Arthritis & rheumatology (Hoboken, N.J.). 2021.05; 73 (12): 2303-2313. ( PubMed, DOI )

  29. Inamo J, Kochi Y, Takeuchi T. Is type 2 diabetes mellitus an inverse risk factor for the development of rheumatoid arthritis? Journal of human genetics. 2021.02; 66 (2): 219-223. ( PubMed, DOI )

  30. Inamo Jun, Kochi Yuta, Takeuchi Tsutomu. 2型糖尿病は関節リウマチ発症の逆危険因子であるか(Is type 2 diabetes mellitus an inverse risk factor for the development of rheumatoid arthritis?) Journal of Human Genetics. 2021.02; 66 (2): 219-223. ( ichushi )

  31. Bing N, Zhou H, Chen X, Hirose T, Kochi Y, Tsuchida Y, Ishigaki K, Sumitomo S, Fujio K, Zhang B, Valdez H, Vincent MS, Martin D, Clark JD. Contribution of a European-Prevalent Variant near CD83 and an East Asian-Prevalent Variant near IL17RB to Herpes Zoster Risk in Tofacitinib Treatment: Results of Genome-Wide Association Study Meta-Analyses. Arthritis & rheumatology (Hoboken, N.J.). 2021.01; 73 (7): 1155-1166. ( PubMed, DOI )

  32. Yin X, Kim K, Suetsugu H, Bang SY, Wen L, Koido M, Ha E, Liu L, Sakamoto Y, Jo S, Leng RX, Otomo N, Laurynenka V, Kwon YC, Sheng Y, Sugano N, Hwang MY, Li W, Mukai M, Yoon K, Cai M, Ishigaki K, Chung WT, Huang H, Takahashi D, Lee SS, Wang M, Karino K, Shim SC, Zheng X, Miyamura T, Kang YM, Ye D, Nakamura J, Suh CH, Tang Y, Motomura G, Park YB, Ding H, Kuroda T, Choe JY, Li C, Niiro H, Park Y, Shen C, Miyamoto T, Ahn GY, Fei W, Takeuchi T, Shin JM, Li K, Kawaguchi Y, Lee YK, Wang Y, Amano K, Park DJ, Yang W, Tada Y, Yamaji K, Shimizu M, Atsumi T, Suzuki A, Sumida T, Okada Y, Matsuda K, Matsuo K, Kochi Y, Japanese Research Committee on Idiopathic Osteonecrosis of the Femoral Head., Kottyan LC, Weirauch MT, Parameswaran S, Eswar S, Salim H, Chen X, Yamamoto K, Harley JB, Ohmura K, Kim TH, Yang S, Yamamoto T, Kim BJ, Shen N, Ikegawa S, Lee HS, Zhang X, Terao C, Cui Y, Bae SC. Meta-analysis of 208370 East Asians identifies 113 susceptibility loci for systemic lupus erythematosus. Annals of the rheumatic diseases. 2020.12; 80 (5): 632-640. ( PubMed, DOI )

  33. Tsuchiya H, Ota M, Sumitomo S, Ishigaki K, Suzuki A, Sakata T, Tsuchida Y, Inui H, Hirose J, Kochi Y, Kadono Y, Shirahige K, Tanaka S, Yamamoto K, Fujio K. Parsing multiomics landscape of activated synovial fibroblasts highlights drug targets linked to genetic risk of rheumatoid arthritis. Annals of the rheumatic diseases. 2020.11; 80 (4): 440-450. ( PubMed, DOI )

  34. Ishigaki K, Akiyama M, Kanai M, Takahashi A, Kawakami E, Sugishita H, Sakaue S, Matoba N, Low SK, Okada Y, Terao C, Amariuta T, Gazal S, Kochi Y, Horikoshi M, Suzuki K, Ito K, Koyama S, Ozaki K, Niida S, Sakata Y, Sakata Y, Kohno T, Shiraishi K, Momozawa Y, Hirata M, Matsuda K, Ikeda M, Iwata N, Ikegawa S, Kou I, Tanaka T, Nakagawa H, Suzuki A, Hirota T, Tamari M, Chayama K, Miki D, Mori M, Nagayama S, Daigo Y, Miki Y, Katagiri T, Ogawa O, Obara W, Ito H, Yoshida T, Imoto I, Takahashi T, Tanikawa C, Suzuki T, Sinozaki N, Minami S, Yamaguchi H, Asai S, Takahashi Y, Yamaji K, Takahashi K, Fujioka T, Takata R, Yanai H, Masumoto A, Koretsune Y, Kutsumi H, Higashiyama M, Murayama S, Minegishi N, Suzuki K, Tanno K, Shimizu A, Yamaji T, Iwasaki M, Sawada N, Uemura H, Tanaka K, Naito M, Sasaki M, Wakai K, Tsugane S, Yamamoto M, Yamamoto K, Murakami Y, Nakamura Y, Raychaudhuri S, Inazawa J, Yamauchi T, Kadowaki T, Kubo M, Kamatani Y. Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases. Nature genetics. 2020.07; 52 (7): 669-679. ( PubMed, DOI )

  35. Ono Chisato, Kochi Yuta, Tanaka Shinya, Yamamoto Kazuhiko, Baba Yoshihiro. Systemic lupus erythematosus and other systemic autoimmune diseases Role of Fcrl5 in B cell immune response and peripheral tolerance(和訳中) 日本免疫学会総会・学術集会記録. 2019.11; 48 (Proceedings): 2-B. ( ichushi )

  36. Motegi T, Kochi Y, Matsuda K, Kubo M, Yamamoto K, Momozawa Y. Identification of rare coding variants in <i>TYK2</i> protective for rheumatoid arthritis in the Japanese population and their effects on cytokine signalling. Annals of the rheumatic diseases. 2019.08; 78 (8): 1062-1069. ( PubMed, DOI )

  37. Akizuki S, Ishigaki K, Kochi Y, Law SM, Matsuo K, Ohmura K, Suzuki A, Nakayama M, Iizuka Y, Koseki H, Ohara O, Hirata J, Kamatani Y, Matsuda F, Sumida T, Yamamoto K, Okada Y, Mimori T, Terao C. PLD4 is a genetic determinant to systemic lupus erythematosus and involved in murine autoimmune phenotypes. Annals of the rheumatic diseases. 2019.04; 78 (4): 509-518. ( PubMed, DOI )

  38. Okada Y, Eyre S, Suzuki A, Kochi Y, Yamamoto K. Genetics of rheumatoid arthritis: 2018 status. Annals of the rheumatic diseases. 2019.04; 78 (4): 446-453. ( PubMed, DOI )

  39. Molineros JE, Looger LL, Kim K, Okada Y, Terao C, Sun C, Zhou XJ, Raj P, Kochi Y, Suzuki A, Akizuki S, Nakabo S, Bang SY, Lee HS, Kang YM, Suh CH, Chung WT, Park YB, Choe JY, Shim SC, Lee SS, Zuo X, Yamamoto K, Li QZ, Shen N, Porter LL, Harley JB, Chua KH, Zhang H, Wakeland EK, Tsao BP, Bae SC, Nath SK. Amino acid signatures of HLA Class-I and II molecules are strongly associated with SLE susceptibility and autoantibody production in Eastern Asians. PLoS genetics. 2019.04; 15 (4): e1008092. ( PubMed, DOI )

  40. Hatano Hiroaki, Ota Mineto, Takeshima Yusuke, Iwasaki Yukiko, Nagafuchi Yasuo, Kochi Yuta, Shoda Hirofumi, Okamura Tomohisa, Fujio Keishi, Yamamoto Kazuhiko. 遺伝学 全身性エリテマトーデス(SLE)と関節リウマチ(RA)患者の末梢血単核球細胞(PBMCs)の多様な免疫細胞サブセットにおけるsplicing quantitative trait loci(sQTL)の影響に関する包括的研究(Genetics A comprehensive study of splicing quantitative trait loci(sQTL) effects in various immune cell subsets in peripheral blood mononuclear cells(PBMCs) of systemic lupus erythematosus(SLE) and rheumatoid arthritis(RA) patients) 日本リウマチ学会総会・学術集会プログラム・抄録集. 2019.03; 63回 325. ( ichushi )

  41. Otani T, Noma H, Sugasawa S, Kuchiba A, Goto A, Yamaji T, Kochi Y, Iwasaki M, Matsui S, Tsunoda T. Exploring predictive biomarkers from clinical genome-wide association studies via multidimensional hierarchical mixture models. European journal of human genetics : EJHG. 2019.01; 27 (1): 140-149. ( PubMed, DOI )

  42. Terao C, Yoshifuji H, Matsumura T, Naruse TK, Ishii T, Nakaoka Y, Kirino Y, Matsuo K, Origuchi T, Shimizu M, Maejima Y, Amiya E, Tamura N, Kawaguchi T, Takahashi M, Setoh K, Ohmura K, Watanabe R, Horita T, Atsumi T, Matsukura M, Miyata T, Kochi Y, Suda T, Tanemoto K, Meguro A, Okada Y, Ogimoto A, Yamamoto M, Takahashi H, Nakayamada S, Saito K, Kuwana M, Mizuki N, Tabara Y, Ueda A, Komuro I, Kimura A, Isobe M, Mimori T, Matsuda F. Genetic determinants and an epistasis of <i>LILRA3</i> and HLA-B*52 in Takayasu arteritis. Proceedings of the National Academy of Sciences of the United States of America. 2018.12; 115 (51): 13045-13050. ( PubMed, DOI )

  43. Tsuchida Y, Sumitomo S, Ota M, Tsuchiya H, Nagafuchi Y, Shoda H, Fujio K, Ishigaki K, Yamaguchi K, Suzuki A, Kochi Y, Yamamoto K. Reduction of CD83 Expression on B Cells and the Genetic Basis for Rheumatoid Arthritis: Comment on the Article by Thalayasingam et al. Arthritis & rheumatology (Hoboken, N.J.). 2018.10; 70 (10): 1695-1696. ( PubMed, DOI )

  44. Sakurai K, Ishigaki K, Shoda H, Nagafuchi Y, Tsuchida Y, Sumitomo S, Kanda H, Suzuki A, Kochi Y, Yamamoto K, Fujio K. HLA-DRB1 Shared Epitope Alleles and Disease Activity Are Correlated with Reduced T Cell Receptor Repertoire Diversity in CD4+ T Cells in Rheumatoid Arthritis. The Journal of rheumatology. 2018.07; 45 (7): 905-914. ( PubMed, DOI )

  45. Sumitomo S, Nagafuchi Y, Tsuchida Y, Tsuchiya H, Ota M, Ishigaki K, Nakachi S, Kato R, Sakurai K, Hanata N, Tateishi S, Kanda H, Suzuki A, Kochi Y, Fujio K, Yamamoto K. A gene module associated with dysregulated TCR signaling pathways in CD4<sup>+</sup> T cell subsets in rheumatoid arthritis. Journal of autoimmunity. 2018.05; 89 21-29. ( PubMed, DOI )

  46. Kochi Y, Kamatani Y, Kondo Y, Suzuki A, Kawakami E, Hiwa R, Momozawa Y, Fujimoto M, Jinnin M, Tanaka Y, Kanda T, Cooper RG, Chinoy H, Rothwell S, Lamb JA, Vencovský J, Mann H, Ohmura K, Myouzen K, Ishigaki K, Nakashima R, Hosono Y, Tsuboi H, Kawasumi H, Iwasaki Y, Kajiyama H, Horita T, Ogawa-Momohara M, Takamura A, Tsunoda S, Shimizu J, Fujio K, Amano H, Mimori A, Kawakami A, Umehara H, Takeuchi T, Sano H, Muro Y, Atsumi T, Mimura T, Kawaguchi Y, Mimori T, Takahashi A, Kubo M, Kohsaka H, Sumida T, Yamamoto K. Splicing variant of <i>WDFY4</i> augments MDA5 signalling and the risk of clinically amyopathic dermatomyositis. Annals of the rheumatic diseases. 2018.04; 77 (4): 602-611. ( PubMed, DOI )

  47. Ishigaki K, Kochi Y, Yamamoto K. Genetics of human autoimmunity: From genetic information to functional insights. Clinical immunology (Orlando, Fla.). 2018.01; 186 9-13. ( PubMed, DOI )

  48. Sumitomo S, Nagafuchi Y, Tsuchida Y, Tsuchiya H, Ota M, Ishigaki K, Suzuki A, Kochi Y, Fujio K, Yamamoto K. Transcriptome analysis of peripheral blood from patients with rheumatoid arthritis: a systematic review. Inflammation and regeneration. 2018; 38 21. ( PubMed, DOI )

  49. Nishino J, Ochi H, Kochi Y, Tsunoda T, Matsui S. Sample Size for Successful Genome-Wide Association Study of Major Depressive Disorder. Frontiers in genetics. 2018; 9 227. ( PubMed, DOI )

  50. Nishino J, Kochi Y, Shigemizu D, Kato M, Ikari K, Ochi H, Noma H, Matsui K, Morizono T, Boroevich KA, Tsunoda T, Matsui S. Empirical Bayes Estimation of Semi-parametric Hierarchical Mixture Models for Unbiased Characterization of Polygenic Disease Architectures. Frontiers in genetics. 2018; 9 115. ( PubMed, DOI )

  51. Terao C, Okada Y, Ikari K, Kochi Y, Suzuki A, Ohmura K, Matsuo K, Taniguchi A, Kubo M, Raychaudhuri S, Yamamoto K, Yamanaka H, Kamatani Y, Mimori T, Matsuda F. Genetic landscape of interactive effects of <i>HLA-DRB1</i> alleles on susceptibility to ACPA(+) rheumatoid arthritis and ACPA levels in Japanese population. Journal of medical genetics. 2017.12; 54 (12): 853-858. ( PubMed, DOI )

  52. Ishigaki K, Kochi Y, Suzuki A, Tsuchida Y, Tsuchiya H, Sumitomo S, Yamaguchi K, Nagafuchi Y, Nakachi S, Kato R, Sakurai K, Shoda H, Ikari K, Taniguchi A, Yamanaka H, Miya F, Tsunoda T, Okada Y, Momozawa Y, Kamatani Y, Yamada R, Kubo M, Fujio K, Yamamoto K. Polygenic burdens on cell-specific pathways underlie the risk of rheumatoid arthritis. Nature genetics. 2017.07; 49 (7): 1120-1125. ( PubMed, DOI )

  53. Nitta T, Kochi Y, Muro R, Tomofuji Y, Okamura T, Murata S, Suzuki H, Sumida T, Yamamoto K, Takayanagi H. Human thymoproteasome variations influence CD8 T cell selection. Science immunology. 2017.06; 2 (12): ( PubMed, DOI )

  54. Molineros JE, Yang W, Zhou XJ, Sun C, Okada Y, Zhang H, Heng Chua K, Lau YL, Kochi Y, Suzuki A, Yamamoto K, Ma J, Bang SY, Lee HS, Kim K, Bae SC, Zhang H, Shen N, Looger LL, Nath SK. Confirmation of five novel susceptibility loci for systemic lupus erythematosus (SLE) and integrated network analysis of 82 SLE susceptibility loci. Human molecular genetics. 2017.03; 26 (6): 1205-1216. ( PubMed, DOI )

  55. Tsuchida Y, Sumitomo S, Ishigaki K, Suzuki A, Kochi Y, Tsuchiya H, Ota M, Komai T, Inoue M, Morita K, Okamura T, Yamamoto K, Fujio K. TGF-β3 Inhibits Antibody Production by Human B Cells. PloS one. 2017; 12 (1): e0169646. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  1. Takahashi Haruka, Hatano Hiroaki, Nakano Masahiro, Tsuchida Yumi, Sumitomo Shuji, Suzuki Akari, Kochi Yuta, Fujio Keishi, Yamamoto Kazuhiko, Ishigaki Kazuyoshi. Systemic Immune Diseases Unravelling the gene regulatory networks driving the polygenetic risk of human complex diseases(タイトル和訳中). 日本免疫学会総会・学術集会記録 2024.11.01

  2. Honda Suguru, Ikari Katsunori, Terao Chikashi, Harigai Masayoshi, Kochi Yuta. 基礎(2) グラフ畳み込みネットワークを用いた自己免疫疾患発症予測のための多遺伝子リスクスコア(Basic 2 Polygenic risk score for predicting the development of autoimmune diseases using graph convolutional networks). 日本リウマチ学会総会・学術集会プログラム・抄録集 2024.03.01

  3. Izuka Shinji, Umezawa Natsuka, Komai Toshihiko, Sugimori Yusuke, Kimura Naoki, Fujieda Yuichiro, Ninagawa Keita, Iwasaki Takeshi, Suzuki Katsuya, Takeuchi Tsutomu, Ohmura Koichiro, Mimori Tsuneyo, Atsumi Tatsuya, Kochi Yuta, Yamamoto Kazuhiko, Yasuda Shinsuke, Okamura Tomohisa, Ota Mineto, Fujio Keishi. 炎症性筋疾患(2) デコンボリューション解析で明らかになった筋炎の潜在的病態 単球の筋浸潤(Inflammatory myopathies 2 Muscle Filtrating Monocytes as a Potential Pathogenesis in Myositis Revealed by Deconvolution Analysis). 日本リウマチ学会総会・学術集会プログラム・抄録集 2024.03.01

  4. Ono Chisato, Kochi Yuta, Tanaka Shinya, Yamamoto Kazuhiko, Baba Yoshihiro. 免疫学的寛容と免疫抑制-2 自己免疫疾患におけるFcrl5の役割(Tolerance and Immune suppression-2 The role of Fcrl5 in autoimmune disease). 日本免疫学会総会・学術集会記録 2022.11.01

  5. Ono Chisato, Kochi Yuta, Tanaka Shinya, Yamamoto Kazuhiko, Baba Yoshihiro. 全身性エリテマトーデスとその他の自己免疫疾患 B細胞免疫応答と末梢免疫寛容におけるFcrl5の役割(Systemic lupus erythematosus and other systemic autoimmune diseases Role of Fcrl5 in B cell immune response and peripheral tolerance). 日本免疫学会総会・学術集会記録 2019.11.01

  6. Tsuchida Yumi, Ota Mineto, Sumitomo Shuji, Yamaguchi Kensuke, Nagafuchi Yasuo, Tsuchiya Haruka, Shoda Hirofumi, Yamamoto Kazuhiko, Kochi Yuta, Fujio Keishi. ヒト免疫学 病因とimmunointervention 様々な分極状態下のT細胞における免疫学的遺伝子発現の遺伝的摂動(Human Immunology: Pathogenesis and Immunointervention Genetic perturbation of immunological gene expression in T cells under different polarizing conditions). 日本免疫学会総会・学術集会記録 2018.12.01

  7. Sugimori Yusuke, Iwasaki Yukiko, Takeshima Yusuke, Ota Mineto, Nagafuchi Yasuo, Sumitomo Shuji, Shoda Hirofumi, Kochi Yuta, Okamura Tomohisa, Yamamoto Kazuhiko, Fujio Keishi. 全身性自己免疫疾患 RNA-Seq transcriptomicsは特発性炎症性ミオパシーの病因に関する各免疫細胞サブセットの潜在的関与を明らかにする(Systemic autoimmune diseases-1 RNA-Seq transcriptomics reveals potential contribution of each immune cell subset to the pathogenesis of idiopathic inflammatory myopathy). 日本免疫学会総会・学術集会記録 2018.12.01

  8. Yamamoto Kazuhiko, Takeshima Yusuke, Iwasaki Yukiko, Ota Mineto, Ishigaki Kazuyoshi, Sumitomo Shuji, Suzuki Akari, Kochi Yuta, Okamura Tomohisa, Fujio Keishi. 自己免疫 リンパ球サブセット特異的トランスクリプトーム解析は全身性エリテマトーデス(SLE)のB細胞異常におけるミトコンドリアの関与を明らかにした(Autoimmunity Lymphocyte subset-specific transcriptome analyses revealed the involvement of mitochondria in B cells abnormality of systemic lupus erythematosus(SLE)). 日本免疫学会総会・学術集会記録 2018.12.01

  9. Tsuchiya Haruka, Ota Mineto, Sumitomo Shuji, Ishigaki Kazuyoshi, Kochi Yuta, Tsuchida Yumi, Shoda Hirofumi, Yamamoto Kazuhiko, Fujio Keishi. 全身性自己免疫疾患 線維芽細胞様滑膜細胞による炎症性メカニズムの免疫遺伝学は関節リウマチ患者を生みだす(Systemic autoimmune diseases-2 The Immunogenetics of Inflammatory Mechanisms by Fibroblast-like Synoviocytes form Rheumatoid Arthritis Patients). 日本免疫学会総会・学術集会記録 2018.12.01

  10. Yanaoka Haruyuki, Nagafuchi Yasuo, Takeshima Yusuke, Ota Mineto, Shirai Harumi, Iwasaki Yukiko, Shoda Hirofumi, Sumitomo Shuji, Okamura Tomohisa, Kochi Yuta, Yamamoto Kazuhiko, Fujio Keishi. 全身性自己免疫疾患 免疫細胞表現型分類によるANCA関連血管炎における疾患特異的白血球サブセットの同定(Systemic autoimmune diseases-1 Identifying disease-specific leukocyte subsets in ANCA-associated vasculitis through immune cell phenotyping). 日本免疫学会総会・学術集会記録 2018.12.01

  11. Takeshima Yusuke, Iwasaki Yukiko, Ota Mineto, Nagafuchi Yasuo, Sumitomo Shuji, Kochi Yuta, Okamura Tomohisa, Yamamoto Kazuhiko, Fujio Keishi. 全身性自己免疫疾患 免疫細胞型特異的multi-omics解析により明らかにされた全身性エリテマトーデスに対するB細胞におけるミトコンドリアの関与(Systemic autoimmune diseases-1 Immune cell-type specific multi-omics analysis revealed contribution of mitochondria in Bcells to systemic lupus erythematosus). 日本免疫学会総会・学術集会記録 2018.12.01

  12. Takeshima Yusuke, Iwasaki Yukiko, Ota Mineto, Ishigaki Kazuyoshi, Sumitomo Shuji, Kochi Yuta, Okamura Tomohisa, Koyasu Shigeo, Yamamoto Kazuhiko, Fujio Keishi. SLEの病因1 全身性エリテマトーデスの病因を明らかにするための免疫細胞サブセットのマルチオミクス解析(SLE pathogenesis(1) Multi-omics analysis of immune cell subsets for revealing the pathogenesis of systemic lupus erythematosus). 日本リウマチ学会総会・学術集会プログラム・抄録集 2018.03.01

  13. Ota Mineto, Ishigaki Kazuyoshi, Sumitomo Shuji, Takeshima Yusuke, Iwasaki Yukiko, Okamura Tomohisa, Kochi Yuta, Yamamoto Kazuhiko, Fujio Keishi. SLEの病因2 さまざまなB細胞サブセットのRNAシーケンスによって明らかになったSLEにおける異常なB細胞受容体レパートリーの成熟(SLE pathogenesis(2) Abnormal B cell receptor repertoire maturation in SLE unveiled by RNA sequencing of various B cell subsets). 日本リウマチ学会総会・学術集会プログラム・抄録集 2018.03.01

  14. Tsuchida Yumi, Sumitomo Shuji, Ishigaki Kazuyoshi, Ota Mineto, Tsuchiya Haruka, Kochi Yuta, Fujio Keishi, Yamamoto Kazuhiko. 遺伝学2 CD83遺伝子における関節リウマチGWAS SNPはB細胞のCD83発現を減少させることで疾患感受性を増大させる(Genetics(2) Rheumatoid Arthritis GWAS SNP in the CD83 Gene May Increase Disease Susceptibility by Decreasing the Expression of CD83 on B Cells). 日本リウマチ学会総会・学術集会プログラム・抄録集 2018.03.01

  15. Tsuchiya Haruka, Sumitomo Shuji, Ishigaki Kazuyoshi, Kochi Yuta, Ota Mineto, Tsuchida Yumi, Shoda Hirofumi, Inui Hiroshi, Taketomi Shuji, Kadono Yuho, Tanaka Sakae, Fujio Keishi, Yamamoto Kazuhiko. 遺伝学2 線維芽細胞様滑膜細胞の総合的解析による関節リウマチに対する新規治療標的としてのidentification EP300(Genetics(2) Identification EP300 as a Novel Therapeutic Target for Rheumatoid Arthritis by the Comprehensive Analysis of Fibroblast-like Synoviocytes). 日本リウマチ学会総会・学術集会プログラム・抄録集 2018.03.01

  16. Ota Mineto, Ishigaki Kazuyoshi, Sumitomo Shuji, Takeshima Yusuke, Iwasaki Yukiko, Kochi Yuta, Yamamoto Kazuhiko, Fujio Keishi. B細胞の発生と機能 免疫細胞のRNAシーケンシングによって明らかになったSLEにおける異常B細胞受容体レパートリーの成熟(B cell development and function Abnormal B cell receptor repertoire maturation in SLE unveiled by RNA sequencing of immune cells). 日本免疫学会総会・学術集会記録 2017.12.01

  17. Tsuchiya Haruka, Sumitomo Shuji, Ishigaki Kazuyoshi, Suzuki Akari, Kochi Yuta, Tsuchida Yumi, Ota Mineto, Shoda Hirofumi, Fujio Keishi, Yamamoto Kazuhiko. 全身性自己免疫疾患(3) 線維芽細胞様滑膜細胞の包括的分析による関節リウマチの新規治療標的としてのEP300の特定(Systemic autoimmune disease(3) Identification EP300 as a Novel Therapeutic Target for Rheumatoid Arthritis by the Comprehensive Analysis of Fibroblast-like Synoviocytes). 日本免疫学会総会・学術集会記録 2017.12.01

  18. Sugimori Yusuke, Iwasaki Yukiko, Takeshima Yusuke, Ota Mineto, Nagafuchi Yasuo, Kochi Yuta, Okamura Tomohisa, Fujio Keishi, Yamamoto Kazuhiko. 全身性自己免疫疾患(3) 特発性炎症性ミオパチー患者由来のPBMCにおける免疫細胞サブセットに関するフローサイトメトリーによる包括的分析(Systemic autoimmune disease(3) Comprehensive Flow Cytometric Analysis of Immune Cell Subsets in PBMCs from Idiopathic Inflammatory Myopathy Patients). 日本免疫学会総会・学術集会記録 2017.12.01

  19. Shirai Harumi, Iwasaki Yukiko, Takeshima Yusuke, Ota Mineto, Nagafuchi Yasuo, Ishigaki Kazuyoshi, Suzuki Akari, Kochi Yuta, Okamura Tomohisa, Fujio Keishi, Yamamoto Kazuhiko. 全身性自己免疫疾患(3) 末梢血におけるリンパ球サブセット分析とRNAシーケンシングによる成人発症スチル病の病態形成に関する検討(Systemic autoimmune disease(3) Investigation of pathogenesis of Adult onset Still's disease through lymphocyte subsets analysis in peripheral blood followed by RNA-sequencing). 日本免疫学会総会・学術集会記録 2017.12.01

  20. Iwasaki Yukiko, Takeshima Yusuke, Ota Mineto, Nagafuchi Yasuo, Sumitomo Shuji, Kochi Yuta, Okamura Tomohisa, Koyasu Shigeo, Fujio Keishi, Yamamoto Kazuhiko. 全身性自己免疫疾患(2) 血漿メタボロミクス分析とトランスクリプトームデータの併用によりSLE患者の層別化ができる(Systemic autoimmune disease(2) Plasma metabolomic analysis combined with transcriptome data has potential for stratification of SLE patients). 日本免疫学会総会・学術集会記録 2017.12.01

  21. Takeshima Yusuke, Iwasaki Yukiko, Ota Mineto, Nagafuchi Yasuo, Ishigaki Kazuyoshi, Sumitomo Shuji, Kochi Yuta, Okamura Tomohisa, Fujio Keishi, Yamamoto Kazuhiko. 全身性自己免疫疾患(2) 末梢血単核細胞(PBMC)における免疫細胞サブセットの総合的ゲノム解析およびトランスクリプトーム解析により全身性エリテマトーデスに対するB細胞ミトコンドリアの寄与が明らかになった(Systemic autoimmune disease(2) Comprehensive analysis of genome and transcriptome analysis of immune cell subsets in peripheral blood mononuclear cells(PBMCs) revealed mitochondria contribution in B cells to systemic lupus erythematosus). 日本免疫学会総会・学術集会記録 2017.12.01

  22. Natsumoto Bunki, Shoda Hirofumi, Lin Huan-Ting, Lai Chen-Yi, Nagafuchi Yasuo, Ishigaki Kazuyoshi, Kochi Yuta, Yamamoto Kazuhiko, Otsu Makoto, Fujio Keishi. 全身性自己免疫疾患(2) 患者由来の人工多能性幹細胞を用いた全身性エリテマトーデス(SLE)の病態生理学的分析(Systemic autoimmune disease(2) Pathophysiological analysis of systemic lupus erythematosus(SLE) using patient-derived induced pluripotent stem cells). 日本免疫学会総会・学術集会記録 2017.12.01

  23. Yamamoto Kazuhiko, Ishigaki Kazuyoshi, Kochi Yuta, Suzuki Akari, Fujio Keishi. 全身性免疫疾患 自己免疫疾患の遺伝情報による機能的考察(Systemic immune diseases Functional insights from genetic information of autoimmune diseases). 日本免疫学会総会・学術集会記録 2017.12.01

  24. Takeshima Yusuke, Iwasaki Yukiko, Ota Mineto, Nagafuchi Yasuo, Sumitomo Shuji, Kochi Yuta, Okamura Tomohisa, Fujio Keishi, Yamamoto Kazuhiko. JSIサマースクールと連携した若手免疫学者対象のワークショップ 全身性エリテマトーデス(SLE)由来の末梢血単核細胞(PBMC)を用いたゲノムおよびトランスクリプトームの統合分析(Workshop for young immunologists collaborated with the JSI summer school Integrative analysis of genome and transcriptome using peripheral blood mononuclear cells(PBMCs) from systemic lupus erythematosus(SLE)). 日本免疫学会総会・学術集会記録 2017.12.01

  25. Ota Mineto, Sumitomo Shuji, Ishigaki Kazuyoshi, Takeshima Yusuke, Iwasaki Yukiko, Kochi Yuta, Fujio Keishi, Yamamoto Kazuhiko. RA-2 RAにおける免疫細胞サブセットのトランスクリプトームによる特徴の分析(RA Transcriptome profiling of immune cell subsets in rheumatoid arthritis). 日本リウマチ学会総会・学術集会プログラム・抄録集 2017.03.01

  26. Natsumoto Bunki, Shoda Hirofumi, Lin Huan-Ting, Lai Chen-Yi, Ishigaki Kazuyoshi, Kochi Yuta, Fujio Keishi, Otsu Makoto, Yamamoto Kazuhiko. SLE-5 SLE患者由来の誘導性多能性幹細胞から分化した免疫細胞の詳細な特性分析(SLE Detailed characterization of immune cells differentiated from SLE patient-derived Induced Pluripotent Stem Cells). 日本リウマチ学会総会・学術集会プログラム・抄録集 2017.03.01

  27. Takeshima Yusuke, Iwasaki Yukiko, Ota Mineto, Ishigaki Kazuyoshi, Sumitomo Shuji, Shoda Hirofumi, Kochi Yuta, Okamura Tomohisa, Fujio Keishi, Yamamoto Kazuhiko. SLE-2 末梢血単核球(PBMCs)の細胞型特異的なRNA-seqから明らかになった全身性エリテマトーデスへのB細胞の寄与(SLE Cell type-specific RNA-seq of peripheral blood mononuclear cells (PBMCs) revealed mitochondria contribution in B cells to systemic lupus erythematosus). 日本リウマチ学会総会・学術集会プログラム・抄録集 2017.03.01

  28. Tsuchiya Haruka, Sumitomo Shuji, Ishigaki Kazuyoshi, Kochi Yuta, Ota Mineto, Tsuchida Yumi, Inui Hiroshi, Taketomi Shuji, Kadono Yuho, Tanaka Sakae, Fujio Keishi, Yamamoto Kazuhiko. RA-7 RA患者由来の線維芽細胞様滑膜細胞における刺激応答によるトランスクリプトームの変化に関する包括的な分析(RA The Comprehensive Analysis for the Transcriptional Organization of Stimuli Responses in Fibroblast-like Synoviocytes from Rheumatoid Arthritis Patients). 日本リウマチ学会総会・学術集会プログラム・抄録集 2017.03.01

  29. Okada Yukinori, Ikari Katsunori, Terao Chikashi, Kochi Yuta, Ohmura Koichiro, Momohara Shigeki, Taniguchi Atsuo, Yamada Ryo, Mimori Tsuneyo, Yamanaka Hisashi, Yamamoto Kazuhiko. RA-6 ACPA陽性のRAの発症リスクに対する非古典的なHLA遺伝子であるHLA-DOAの量の寄与(RA Dosage contribution of a non-classical HLA gene, HLA-DOA, to the risk of ACPA-positive rheumatoid arthritis). 日本リウマチ学会総会・学術集会プログラム・抄録集 2017.03.01

  30. Ishigaki Kazuyoshi, Kochi Yuta, Ikari Katsunori, Taniguchi Atsuo, Yamanaka Hisashi, Yamamoto Kazuhiko. RA-5 RAの大規模全ゲノム関連解析研究への集団特異的な帰属参照パネルの応用(RA Application of population-specific imputation reference panel to large-scale genome-wide association study of rheumatoid arthritis). 日本リウマチ学会総会・学術集会プログラム・抄録集 2017.03.01

  31. Terao Chikashi, Ikari Katsunori, Kochi Yuta, Okada Yukinori, Ohmura Koichiro, Taniguchi Atsuo, Momohara Shigeki, Yamamoto Kazuhiko, Yamanaka Hisashi, Mimori Tsuneyo. RA-2 RAの罹患性に対するHLA-DRB1アレルの集団特異的な相互作用(RA Population-specific interactive effects of HLA-DRB1 alleles on susceptibility to rheumatoid arthritis). 日本リウマチ学会総会・学術集会プログラム・抄録集 2017.03.01

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Others 【 display / non-display

  • Groundbreaking Study Uncovers New Insights into Alternative Splicing and Disease Associations,2024.06

  • A new data analysis approach identifies disease-associated splicing variants,2022.09

  • Predicting the progression of rheumatoid arthritis,2022.03

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