Personnel Information

写真a

KOBAYASHI Miho


Job title

Assistant Professor

Mail Address

The inquiry by e-mail is 《here》
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Graduate School 【 display / non-display 】

  • Tohoku University, Graduate School of Life Science, Department of Biomolecular Sciences, Doctor's Course, 2006.03, Completed

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Degree 【 display / non-display 】

  • Ph.D. in Life Science, Tohoku University

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Campus Career 【 display / non-display 】

  • 2019.05
    -
    2021.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Matrix， Biochemistry， Assistant Professor
  • 2019.05
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Matrix， Biochemistry， Assistant Professor
  • 2021.04
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Division of Bio-Matrix， Department of Biochemistry， Assistant Professor
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External Career 【 display / non-display 】

  • 2018.08
    -
    2019.04
    , Assistant Professor
  • 2017.06
    -
    2018.08
    , Project Researcher
  • 2012.04
    -
    2018.08
    , Assistant Professor
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Academic Society Affiliations 【 display / non-display 】

  • The Japanese Society of Lymphology

  • Japan Society for Cell Biology

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Research Areas 【 display / non-display 】

  • Pathological biochemistry

  • Vascular Biology

  • Tumor biology

  • Cell biology

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Published Papers & Misc 【 display / non-display 】

  1. Shihori Tokizaki, Katarzyna Inoue, Takehisa Matsumoto, Kazuki Takahashi, Miho Kobayashi, Haruka Ibi, Shizuka Uchida, Sadahiro Iwabuchi, Hiroyuki Harada, Shinichi Hashimoto, Kohei Miyazono, Mikako Shirouzu, Tetsuro Watabe. Inhibition of TGF-β signals suppresses tumor formation by regulation of tumor microenvironment networks Cancer Science. 2023.11; on line ahead of print ( PubMed, DOI )

  2. Kazuki Takahashi*, Miho Kobayashi*, Hisae Katsumata, Shiori Tokizaki, Tatsuhiko Anzai, Yukinori Ikeda, Daniel M. Alcaide, Kentaro Maeda, Makoto Ishihara, Katsutoshi Tahara, Yoshiaki Kubota, Fumiko Itoh, Jihwan Park, Kunihiko Takahashi, Yukiko T. Matsunaga, Yasuhiro Yoshimatsu, Katarzyna A. Podyma-Inoue, Tetsuro Watabe (*: equally contribution). CD40 is expressed in the subsets of endothelial cells undergoing partial endothelial-mesenchymal transition in tumor microenvironment. Cancer Science. 2023.11; 115 (2): 490-506. ( PubMed, DOI )

  3. Miho Kobayashi, Kashio Fujiwara, Kazuki Takahashi, Yusuke Yoshioka, Takahiro Ochiya, Katarzyna A. Podyma-Inoue, Tetsuro Watabe. Transforming growth factor-β-induced secretion of extracellular vesicles from oral cancer cells evokes endothelial barrier instability via endothelial-mesenchymal transition Inflammation and Regeneration. 2022.09; 42 (1): 38. ( PubMed, DOI )

  4. Kobayashi M, Wakabayashi I, Suzuki Y, Fujiwara K, Nakayama M, Watabe T, Sato Y. Tubulin carboxypeptidase activity of vasohibin-1 inhibits angiogenesis by interfering with endocytosis and trafficking of pro-angiogenic factor receptors Angiogenesis. 2021.02; 24 (1): 159-176. ( PubMed, DOI )

  5. Yoshimatsu Y, Wakabayashi I, Kimuro S, Takahashi N, Takahashi K, Kobayashi M, Maishi N, Podyma-Inoue KA, Hida K, Miyazono K, Watabe T. TNF-α enhances TGF-β-induced endothelial-to-mesenchymal transition via TGF-β signal augmentation. Cancer Science. 2020.07; 111 (7): 2385-2399. ( PubMed, DOI )

  6. Kobayashi M, Suzuki Y, Sato Y.. The post‐translational modification of microtubules mediates The American Society th for Cell Biology 56th Annual Meeting. 2016.12; p383.

  7. Phowichit S, Kobayashi M, Fujinoya Y, Sato Y, Sanphanya K, Vajragupta O, Chularojmontri L, Wattanapitayakul SK.. Antiangiogenic Effects of VH02, a Novel Urea Derivative: In Vitro and in Vivo Studies. Molecules. 2016.09; 21 (9): 1258.

  8. Horie S, Suzuki Y, Kobayashi M, Kadonosono T, Kizaka-Kondoh S, Kodama T, Sato Y.. Distinctive role of vasohibin-1A and its splicing variant vasohibin-1B in tumor angiogenesis. Cancer Gene therapy. 2016.05; 23 (5): 133-141.

  9. Suenaga K, Kitahara S, Suzuki Y, Kobayashi M, Horie S, Sugawara J, Yaegashi N, Sato Y.. The angiogenic factor, VASH2 regulate placental morphogenesis with the control of cell fusion. PLACENTA. 2014.10; 35 (10): A19.

  10. Suenaga K, Kitahara S, Suzuki Y, Kobayashi M, Horie S, Sugawara J, Yaegashi N, Sato Y.. Role of the vasohibin family in the regulation of fetoplacental vascularization and syncytiotrophoblast formation. PLoS One. 2014.09; 9 (9): e104728.

  11. Koyanagi T, Suzuki Y, Kobayashi M, Miyashita H, Saga Y, Suzuki M, Sato Y.. Development of a novel anti-angiogenic cancer therapy targeting vasohibin-2. Angioenesis. 2014.07; 17 (3): 751.

  12. Ito S, Miyashita H, Suzuki Y, Kobayashi M, Satomi S, Sato Y.. Enhanced cancer metastasis in mice deficient in vasohibin-1 gene. PLoS One. 2013.09; 8 (9): e73931.

  13. Suzuki Y, Kobayashi M, Miyashita H, Ohta H, Sonoda H, Sato Y.. Isolation of a small vasohibin-binding protein (SVBP) and its role in vasohibin secretion. Journal of Cell Science. 2010.09; 123 3094-3101.

  14. Kimura H, Miyashita H, Suzuki Y, Kobayashi M, Watanabe K, Sonoda H, Ohta H, Fujiwara T, Shimosegawa T, Sato Y.. Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis. Blood. 2009.05; 113 4810-4818.

  15. Kobayashi M, Nishita M, Mishima T, Ohashi K, Mizuno K. MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration. The EMBO Journal. 2006.02; 25 713-716.

  16. Kobayashi M, Nishita M, Ohashi K, Mizuno K.. VEGF-induced LIM Kinase 1 Phosphorylation and Activation are Required for Actin Cytoskeletal Reorganization and Migration of Endothelial Cell. The American Society th for Cell Biology 45th Annual Meeting. 2005.12; 637a.

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Conference Activities & Talks 【 display / non-display 】

  1. Miho Kobayashi, Honoka Hirose, Masanori Nakayama, Tetsuro Watabe. Attenuation of the stress response is involved in the age-related reduction of microvascular density. Asia-Australia Vascular Biology Meeting 2023 (AAVBM2023) 2023.09.14 Korea

  2. Kazuki Takahashi, Miho Kobayashi, Hisae Katsumata, Yukinori Ikeda, Tatsuhiko Anzai, Katarzyna A. Podyma-Inoue, Daniel M Alcaide, Kentaro Maeda, Jihwan Park, Kunihiko Takahashi, Yukiko Matsunaga, Yasuhiro Yoshimatsu, Tetsuro Watabe. Endothelial-mesenchymal transition (EndoMT) reporter cells visualized multiple groups of cells during progression of TGF-β induced EndoMT. Asia-Australia Vascular Biology Meeting 2023 (AAVBM 2023) 2023.09.14 Seoul, Korea

  3. 小林 美穂, 廣瀬 穂香, 中山 雅敬, 渡部 徹郎. 加齢に伴う血管内皮細胞の減少とストレス応答性の関係. 第30回日本血管生物医学会学術集会（CVMW2022） 2022.12.16

  4. 小林 美穂、藤原 花汐、高橋 和樹、吉岡 祐亮、落谷 孝広、渡部 徹郎. 口腔扁平上皮がん細胞由来細胞外小胞による血管不安定化機構. 第87回 口腔病学会学術大会 2022.12.03 東京

  5. 小林 美穂, 廣瀬 穂香, 小林 ゆめ, 渡部 徹郎. Vasohibin-1が細胞内輸送に及ぼす影響とその役割. 第45回日本分子生物学会年会 2022.12.01 幕張

  6. Miho Kobayashi, Honoka Hirose, Masanori Nakayama, Tetsuro Watabe. Relationship between age-dependent vascular endothelial cell decline and stress responsiveness. The 22nd International Vascular Biology Meeting (IVBM2022) 2022.10.14 Oakland, USA

  7. 小林 美穂, 藤原 花汐, 鈴木 康弘, 若林 育海, 中山 雅敬, 佐藤 靖史, 渡部 徹郎. 微小管の翻訳後修飾による細胞内輸送調節を介したシグナル伝達制御機構とその役割. 第74回日本細胞生物学会大会 2022.06.30 東京

  8. 高橋 和樹, 勝又 寿枝, 小林 美穂, 池田 行徳, 篠原 満利恵,前田 健太郎, 吉松 康裕, 松永 行子, 渡部 徹郎. 内皮間葉移行(EndoMT)レポーター内皮細胞を用いたEndoMTの可視化とがん細胞の脈管内侵入機序の解明. 第46回日本リンパ学会総会 2022.06.04 東京

  9. 小林 美穂. 口腔がん細胞が放出するエクソソームによる血管不安定化機構. 第7回 日本血管生物医学会若手研究会 2022.03.05 淡路島（オンライン ハイブリッド）

  10. Miho Kobayashi、Kashio Fujiwara、Ikumi Wakabayashi、Yasuhiro Suzuki、Masanori Nakayama、Yasufumi Sato、Tetsuro Watabe. Novel anti-angiogenic mechanism of VASH1 through the modification of microtubules. CVMW2020心血管代謝週間（第28回日本血管生物医学会学術集会） 2021.03.12 Web

  11. Miho KOBAYASHI, Ikumi Wakabayashi, Yasuhiro Suzuki, Kashio Fujiwara, Masanori Nakayama, Yasufumi Sato, Tetsuro Watabe. Vasohibin-1 induced post-translational modification of microtubules mediates VEGF-signaling in angiogenesis. 第42回日本分子生物学会年会（MBSJ2020） 2020.12.03 WEB

  12. Miho Kobayashi,Ikumi Wakabayashi,Yasuhiro Suzuki,Yasufumi Sato,Tetsuro Watabe. Vasohibin-1 Inhibits Angiogenesis via the Increase of Detyrosinated α-Tubulin. The 21st International Vascular Biology Meeting (IVBM2020) 2020.09.09 Korea (WEB hybrid)

  13. Miho Kobayashi, Yasuhiro Suzuki, Yasufumi Sato. The post-translational modificationof microtubules mediates angiogenic signaling.. The 2017 Japan-NIH joint Symposium 2017.02.16

  14. Miho Kobayashi, Yasuhiro Suzuki, Yasufumi Sato.. The post-translatonal modificaton of microtubules mediates receptor signaling.. 56th Annual Meeting of The American Society for Cell Biology (ASCB2016) 2016.12.04

  15. Miho Kobayashi, Yasuhiro Suzuki, Yasufumi Sato.. Vasohibin-1 induces suppression of VEGF-signaling via post-translational modification of MTs.. The 10th Vasohibin Meeting 2015.01.10

  16. Takahiro Koyanagi, Yasuhiro Suzuki, Miho Kobayashi, Hiroki Miyashita, Yasushi Saga, Mitsuaki Suzuki, Yasufumi Sato.. Development of a novel anti-angiogenic cancer therapy targeting vasohibin-2.. The 18th International Vascular Biology Meeting (IVBM2014) 2014.04.15

  17. Sachiko Horie, Yasuhiro Suzuki, Miho Kobayashi, Yasufumi Sato.. Distinctive roles of Vasohibin-1A and Vasohibin-1B in angiogenesis regulation.. The 18th International Vascular Biology Meeting (IVBM2014) 2014.04.14

  18. Kaori Suenaga, Shuji Kitahara, Yasuhiro Suzuki, Miho Kobayashi, Sachiko Horie, Junichi Sugawara, Nobuo Yaegashi, Yasufumi Sato. Role of the vasohibin family in the regulation of placental morphogenesis.. The 18th International Vascular Biology Meeting (IVBM2014) 2014.04.14

  19. Takahiro Koyanagi, Yasuhiro Suzuki, Miho Kobayashi, Hiroki Miyashita, Yasushi Saga, Mitsuaki Suzuki, Yasufumi Sato. Development of a novel anti-angiogenic cancer therapy targeting vasohibin-2 . 5th International meeting on angiogenesis 2014.03 Amsterdam

  20. Miho Kobayashi, Yasuhiro Suzuki, Yasufumi Sato.. Vasohibin-1 exerts anti-angiogenic effect via post-translational modification of microtubules.. Network Medicine Winter Camp of GCOE -The Cultivation for New Generation of Scientists- 2011.02.05

  21. Miho Kobayashi, Yasuhiro Suzuki, Yasufumi Sato.. Vasohibin-1 inhibits directional endothelial cellmigration via detyronation of α-tubulin.. The 16th International Vascular Biology Meeting 2010.06.22

  22. Miho Kobayashi, Michiru Nishita, Toshiaki Mishima, Kazumasa Ohashi, Kensaku Mizuno.. VEGF-induced angiogenesis requires MAPKAP Kinase 2 mediated LIM kinase 1 phosphorylation and activation.. The 3rd International Symposium -Novel perspectives in cancer research and translation to the clinic- 2006.11.09

  23. Miho Kobayashi, Kazumasa Ohashi, Kensaku Mizuno.. Stimulus-dependent LIMK1 activation is regulated by the phosphorylation of distinct sites.. The 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB congress 2006.06.19

  24. Miho Kobayashi, Michiru Nishita, Kazumasa Ohashi, Kensaku Mizuno. VEGF-induced LIM kinase 1 phosphorylation and activation are required for actin cytoskeletal reorganization and migration of endothelial cell.. The 45th Annual Meeting of The American Society for Cell Biology (ASCB2005) 2005.12.14

  25. Miho Kobayashi, Michiru Nishita, Kazumasa Ohashi, Kensaku Mizuno. LIM kinase regulates vascular endothelial growth factor-induced actin cytoskeletal reorganization.. The 43th Annual Meeting of The American Society for Cell Biology (ASCB2003) 2003.12

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Awards & Honors 【 display / non-display 】

  • The JVBMO/IVBM 2020 Best E-poster Awards (1st Place)，JVBMO, IVBM，2020.09

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Others 【 display / non-display 】

  • Towards a better understanding of endothelial cell transformation in cancer progression，2024.02

  • Promotion of cancer progression via extracellular vesicles，2022.11

  • Hinder Handing the Message - Stopping Tumors from Creating New Blood Vessels，2020.12

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