Personnel Information

写真a

FUJIYOSHI Yoshinori


Job title

Distinguished Professor

Field Introduction URL

細胞構造生理学研究室

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Graduating School 【 display / non-display 】

  • Nagoya University, Faculty of Science, 1971.03, Graduated

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Graduate School 【 display / non-display 】

  • Kyoto University, Graduate School, Division of Natural Science, Doctor's Course, 1979.03, Accomplished credits for doctoral program

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Campus Career 【 display / non-display 】

  • 2019.04
    -
    2022.06
    Tokyo Medical and Dental University， TMDU Advanced Research Institute (TMDU-ARIS)， ， Distinguished Professor
  • 2022.07
    -
    Now
    Tokyo Medical and Dental University， TMDU Advanced Research Institute (TMDU-ARIS)， ， Cellular and Structural Physiology Laboratory (CeSPL)， Distinguished Professor
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Research Areas 【 display / non-display 】

  • Structural biochemistry

  • Cell biology

  • Molecular biology

  • Biophysics

  • Pharmaceutical chemistry and drug development sciences

  • Clinical pharmacy

  • Physiology

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Published Papers & Misc 【 display / non-display 】

  1. Hiroki Yamaguchi, Kazutoshi Takahashi, Nobutaka Numoto, Hiroshi Suzuki, Moemi Tatsumi, Akiko Kamegawa, Kouki Nishikawa, Yasuhisa Asano, Toshimi Mizukoshi, Hiroshi Miyano, Yoshinori Fujiyoshi, Masayuki Sugiki. Open and closed structures of L-arginine oxidase by cryo-electron microscopy and X-ray crystallography. J Biochem. 2024.10; ( PubMed, DOI )

  2. Shota Suzuki, Kotaro Tanaka, Kouki Nishikawa, Hiroshi Suzuki, Atsunori Oshima, Yoshinori Fujiyoshi. Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding. Nat Commun. 2023.09; 14 (1): 5899. ( PubMed, DOI )

  3. Shunsuke Imai, Hiroshi Suzuki, Yoshinori Fujiyoshi, Ichio Shimada. Dynamically regulated two-site interaction of viral RNA to capture host translation initiation factor. Nat Commun. 2023.08; 14 (1): 4977. ( PubMed, DOI )

  4. Katsumasa Irie, Yoshinori Oda, Takashi Sumikama, Atsunori Oshima, Yoshinori Fujiyoshi. The structural basis of divalent cation block in a tetrameric prokaryotic sodium channel. Nat Commun. 2023.07; 14 (1): 4236. ( PubMed, DOI )

  5. Akiko Kamegawa, Shota Suzuki, Hiroshi Suzuki, Kouki Nishikawa, Nobutaka Numoto, Yoshinori Fujiyoshi. Structural analysis of the water channel AQP2 by single-particle cryo-EM. J Struct Biol. 2023.06; 215 107984. ( PubMed, DOI )

  6. Daisuke Kozai, Nobutaka Numoto, Kouki Nishikawa, Akiko Kamegawa, Shohei Kawasaki, Yoko Hiroaki, Katsumasa Irie, Atsunori Oshima, Hiroyuki Hanzawa, Kousei Shimada, Yutaka Kitano, Yoshinori Fujiyoshi. Recognition Mechanism of a Novel Gabapentinoid Drug, Mirogabalin, for Recombinant Human α2δ1, a Voltage-Gated Calcium Channel Subunit J Mol Biol. 2023.03; 168049. ( PubMed, DOI )

  7. Yukihiro Tanimura, Yoko Hiroaki, Masahiro Mori, Yoshinori Fujiyoshi. Cell-based flow cytometry assay for simultaneous detection of multiple autoantibodies in a single serum sample. Anal Biochem. 2022.08; 650 114721. ( PubMed, DOI )

  8. Katerina Naydenova, Akiko Kamegawa, Mathew J Peet, Richard Henderson, Yoshinori Fujiyoshi, Christopher J Russo. On the reduction in the effects of radiation damage to two-dimensional crystals of organic and biological molecules at liquid-helium temperature. Ultramicroscopy. 2022.07; 237 113512. ( PubMed, DOI )

  9. Maki Kuzuya, Hidemi Hirano, Kenichi Hayashida, Masakatsu Watanabe, Kazumi Kobayashi, Tohru Terada, Md Iqbal Mahmood, Florence Tama, Kazutoshi Tani, Yoshinori Fujiyoshi, Atsunori Oshima. Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids. Sci Signal. 2022.02; 15 (720): eabg6941. ( PubMed, DOI )

  10. Yukako Oda, Chisato Takahashi, Shota Harada, Shun Nakamura, Daxiao Sun, Kazumi Kiso, Yuko Urata, Hitoshi Miyachi, Yoshinori Fujiyoshi, Alf Honigmann, Seiichi Uchida, Yasushi Ishihama, Fumiko Toyoshima. Discovery of anti-inflammatory physiological peptides that promote tissue repair by reinforcing epithelial barrier formation. Sci Adv. 2021.11; 7 (47): eabj6895. ( PubMed, DOI )

  11. Hanayo Nakanishi, Tomohiro Nishizawa, Katsumori Segawa, Osamu Nureki, Yoshinori Fujiyoshi, Shigekazu Nagata, Kazuhiro Abe. Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM. Cell Rep. 2020.09; 32 (13): 108208. ( PubMed, DOI )

  12. Shimada Atsuhiro, Kozai Daisuke, Nishikawa Kouki, Fujiyoshi Yoshinori, Sho Gyokucho, Mizutani Takumi, Tani Kazutoshi. クライオ電子顕微鏡を用いたシトクロム酸化酵素とシトクロムcの複合体構造解析(The structural analysis of cytochrome c oxidase complexed with cytochrome c using cryo-electron microscopy) 生物物理. 2020.08; 60 (Suppl.1-2): S158. ( ichushi )

  13. Irie Katsumasa, Shimomura Takushi, Yonekawa Yoshiki, Nagura Hitoshi, Tateyama Michihiro, Fujiyoshi Yoshinori. 天然の原核生物由来カルシウムチャネルにおけるイオン透過選択性の進化とその決定残基の同定(The selectivity determinant and evolution of a native prokaryotic voltage-dependent calcium channel) 生物物理. 2020.08; 60 (Suppl.1-2): S248. ( ichushi )

  14. Hanayo Nakanishi, Katsumasa Irie, Katsumori Segawa, Kazuya Hasegawa, Yoshinori Fujiyoshi, Shigekazu Nagata, Kazuhiro Abe. Crystal structure of a human plasma membrane phospholipid flippase. J Biol Chem. 2020.07; 295 (30): 10180-10194. ( PubMed, DOI )

  15. B. Burendei, R. Shinozaki, M. Watanabe, T. Terada, K. Tani, Y. Fujiyoshi and A. Oshima. Cryo-EM structures of undocked innexin-6 hemichannels in phospholipids. Sci. Adv.. 2020.02; 6 (7): ( DOI )

  16. Takushi Shimomura, Yoshiki Yonekawa, Hitoshi Nagura, Michihiro Tateyama, Yoshinori Fujiyoshi, Katsumasa Irie. A native prokaryotic voltage-dependent calcium channel with a novel selectivity filter sequence. Elife. 2020.02; 9 ( PubMed, DOI )

  17. K. Yamamoto, V. Dubey, K. Irie, H. Nakanishi, H. Khandelia, Y. Fujiyoshi and K. Abe. A single K+-binding site in the crystal structure of the gastric proton pump. eLife. 2019.08; 8 ( DOI )

  18. Shun Nakamura, Katsumasa Irie, Hiroo Tanaka, Kouki Nishikawa, Hiroshi Suzuki, Yasunori Saitoh, Atsushi Tamura, Sachiko Tsukita & Yoshinori Fujiyoshi. Morphologic determinant of tight junctions revealed by claudin-3 structures Nature Communications. 2019.02; 10 816. ( DOI )

  19. Hiroki Yamaguchi, Akiko Kamegawa, Kunio Nakata, Tatsuki Kashiwagi, Toshimi Mizukoshi, Yoshinori Fujiyoshi, Kazutoshi Tani. Structural insights into thermostabilization of leucine dehydrogenase from its atomic structure by cryo-electron microscopy Journal of Structural Biology. 2019.01; 205 (1): 11-21. ( DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. 藤吉好則. Cryo-EM changes structural biology [Tutorial Lecture]. ALC '19 2019.10.23

  2. 藤吉好則. Structure-guided drug development by cryo-EM [Plenary Lecture]. International Symposium on Diffraction Structural Biology 2019 2019.10.18

  3. 藤吉好則. Drug rescuing based on structure analyses by cryo-EM. インベスターR&D Day 2019.09.12

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