Yusuke Kiyoki, Takayasu Kato, Sakura Kito, Takashi Matsuzaka, Shin Morioka, Junko Sasaki, Kenichi Makishima, Tatsuhiro Sakamoto, Hidekazu Nishikii, Naoshi Obara, Mamiko Sakata-Yanagimoto, Takehiko Sasaki, Hitoshi Shimano, Shigeru Chiba. The fatty acid elongase Elovl6 is crucial for hematopoietic stem cell engraftment and leukemia propagation. Leukemia. 2023.03; ( PubMed, DOI )

Takahito Miyake, Yuichi Inoue, Xinyan Shao, Takehito Seta, Yuto Aoki, Khanh Tien Nguyen Pham, Yuichi Shichino, Junko Sasaki, Takehiko Sasaki, Masahito Ikawa, Yoshiaki Yamaguchi, Hitoshi Okamura, Shintaro Iwasaki, Masao Doi. Minimal upstream open reading frame of Per2 mediates phase fitness of the circadian clock to day/night physiological body temperature rhythm. Cell Rep. 2023.02; 112157. ( PubMed, DOI )

Tomonori Ayukawa, Masakazu Akiyama, Yasukazu Hozumi, Kenta Ishimoto, Junko Sasaki, Haruki Senoo, Takehiko Sasaki, Masakazu Yamazaki. Tissue flow regulates planar cell polarity independently of the Frizzled core pathway. Cell Rep. 2022.09; 40 (12): 111388. ( PubMed, DOI )

Kaori Kanemaru, Makoto Shimozawa, Manabu Kitamata, Rikuto Furuishi, Hinako Kayano, Yui Sukawa, Yuuki Chiba, Takatsugu Fukuyama, Junya Hasegawa, Hiroki Nakanishi, Takuma Kishimoto, Kazuya Tsujita, Kazuma Tanaka, Toshiki Itoh, Junko Sasaki, Takehiko Sasaki, Kiyoko Fukami, Yoshikazu Nakamura. Plasma membrane phosphatidylinositol (4,5)-bisphosphate is critical for determination of epithelial characteristics. Nat Commun. 2022.05; 13 (1): 2347. ( PubMed, DOI )

Shin Morioka, Hiroki Nakanishi, Toshiyoshi Yamamoto, Junya Hasegawa, Emi Tokuda, Tomoya Hikita, Tomoko Sakihara, Yuuki Kugii, Chitose Oneyama, Masakazu Yamazaki, Akira Suzuki, Junko Sasaki, Takehiko Sasaki. A mass spectrometric method for in-depth profiling of phosphoinositide regioisomers and their disease-associated regulation. Nat Commun. 2022.01; 13 (1): 83. ( PubMed, DOI )

Asami Kawasaki, Akiko Sakai, Hiroki Nakanishi, Junya Hasegawa, Tomohiko Taguchi, Junko Sasaki, Hiroyuki Arai, Takehiko Sasaki, Michihiro Igarashi, Fubito Nakatsu. PI4P/PS countertransport by ORP10 at ER-endosome membrane contact sites regulates endosome fission. J Cell Biol. 2022.01; 221 (1): ( PubMed, DOI )

1. Kawai T, Miyata H, Nakanishi H, Sakata S, Morioka S, Sasaki J, Watanabe M, Sakimura K, Fujimoto T, Sasaki T, Ikawa M & Okamura Y.. PtdIns(4,5)P2 Distribution Mediated by a Voltage-Sensing Phosphatase (VSP) Regulates Sperm Motility. Proc. Natl. Acad. Sci. USA. 2019.12; 116 (51): 26020-26028. ( DOI )

Koizumi A, Narita S, Nakanishi H, Ishikawa M, Eguchi S, Kimura H, Takasuga S, Huang M, Inoue T, Sasaki J, Yoshioka T, Habuchi T & Sasaki T.. Increased fatty acyl saturation of phosphatidylinositol phosphates in prostate cancer progression. Sci Rep. 2019.09; 9 (1): 13257. ( DOI )

Takemasu Shinya、Ito Masaki、Morioka Shin、Nigorikawa Kiyomi、Kofuji Satoshi、Takasuga Shunsuke、Eguchi Satoshi、Nakanishi Hiroki、Matsuoka Isao、Sasaki Junko、Sasaki Takehiko、 Hazeki Kaoru. Lysophosphatidylinositol-acyltransferase-1 is involved in cytosolic Ca2+ oscillations in macrophages. Genes to Cells. 2019.03; 24 (5): 366-376. ( DOI )

Fujioka Yoichiro、Satoh Aya O.、Horiuchi Kosui、Fujioka Mari、Tsutsumi Kaori、Sasaki Junko、 Nepal Prabha、Kashiwagi Sayaka、Paudel Sarad、Nishide Shinya、Nanbo Asuka、Sasaki Takehiko、 Ohba Yusuke. A Peptide Derived from Phosphoinositide 3-kinase Inhibits Endocytosis and Influenza Virus Infection Cell Structure and Function. 2019.03; 44 (1): 61-74. ( DOI )

Hirotaka Kimura, Yasushi Matsuyama, Sachiko Araki, Atsushi Koizumi, Yumi Kariya, Shunsuke Takasuga, Satoshi Eguchi, Hiroki Nakanishi, Junko Sasaki, Takehiko Sasaki. The effect and possible clinical efficacy of in vivo inhibition of neutrophil extracellular traps by blockade of PI3K-gamma on the pathogenesis of microscopic polyangiitis. Mod Rheumatol. 2018.05; 28 (3): 530-541. ( PubMed, DOI )

Marc C Liggins, Jessica L Flesher, Sohail Jahid, Priya Vasudeva, Victoria Eby, Shunsuke Takasuga, Junko Sasaki, Takehiko Sasaki, Raymond E Boissy, Anand K Ganesan. PIKfyve regulates melanosome biogenesis. PLoS Genet.. 2018.05; 14 (3): e1007290. ( PubMed, DOI )

Mouhannad Malek, Anna Kielkowska, Tamara Chessa, Karen E Anderson, David Barneda, Pınar Pir, Hiroki Nakanishi, Satoshi Eguchi, Atsushi Koizumi, Junko Sasaki, Véronique Juvin, Vladimir Y Kiselev, Izabella Niewczas, Alexander Gray, Alexandre Valayer, Dominik Spensberger, Marine Imbert, Sergio Felisbino, Tomonori Habuchi, Soren Beinke, Sabina Cosulich, Nicolas Le Novère, Takehiko Sasaki, Jonathan Clark, Phillip T Hawkins, Len R Stephens. PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K. Mol. Cell. 2017.11; 68 (3): 566-580.e10. ( PubMed, DOI )

Hideo Shindou, Hideto Koso, Junko Sasaki, Hiroki Nakanishi, Hiroshi Sagara, Koh M Nakagawa, Yoshikazu Takahashi, Daisuke Hishikawa, Yoshiko Iizuka-Hishikawa, Fuyuki Tokumasu, Hiroshi Noguchi, Sumiko Watanabe, Takehiko Sasaki, Takao Shimizu. Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells. J. Biol. Chem.. 2017.07; 292 (29): 12054-12064. ( PubMed, DOI )

Yoshiko Iizuka-Hishikawa, Daisuke Hishikawa, Junko Sasaki, Keiyo Takubo, Motohito Goto, Katsuyuki Nagata, Hiroki Nakanishi, Hideo Shindou, Tadashi Okamura, Chizuru Ito, Kiyotaka Toshimori, Takehiko Sasaki, Takao Shimizu. Lysophosphatidic acid acyltransferase 3 tunes the membrane status of germ cells by incorporating docosahexaenoic acid during spermatogenesis. J. Biol. Chem.. 2017.07; 292 (29): 12065-12076. ( PubMed, DOI )

Hirotaka Kimura, Satoshi Eguchi, Junko Sasaki, Keiji Kuba, Hiroki Nakanishi, Shunsuke Takasuga, Masakazu Yamazaki, Akiteru Goto, Hiroyuki Watanabe, Hiroshi Itoh, Yumiko Imai, Akira Suzuki, Noboru Mizushima, Takehiko Sasaki. Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy. JCI Insight. 2017.01; 2 (1): e89462. ( PubMed, DOI )

Shin Morioka, Kiyomi Nigorikawa, Junko Sasaki, Kaoru Hazeki, Yoshihiro Kasuu, Takehiko Sasaki, Osamu Hazeki. Myeloid cell-specific inositol polyphosphate-4-phosphatase type I knockout mice impair bacteria clearance in a murine peritonitis model. Innate Immun. 2016.08; 22 (6): 444-451. ( PubMed, DOI )

Kiyomi Nigorikawa, Kaoru Hazeki, Junko Sasaki, Yumio Omori, Mikiko Miyake, Shin Morioka, Ying Guo, Takehiko Sasaki, Osamu Hazeki. Inositol Polyphosphate-4-Phosphatase Type I Negatively Regulates Phagocytosis via Dephosphorylation of Phagosomal PtdIns(3,4)P2. PLoS ONE. 2015.11; 10 (11): e0142091. ( PubMed, DOI )

Satoshi Kofuji, Hirotaka Kimura, Hiroki Nakanishi, Hiroshi Nanjo, Shunsuke Takasuga, Hui Liu, Satoshi Eguchi, Ryotaro Nakamura, Reietsu Itoh, Noriko Ueno, Ken Asanuma, Mingguo Huang, Atsushi Koizumi, Tomonori Habuchi, Masakazu Yamazaki, Akira Suzuki, Junko Sasaki, Takehiko Sasaki. INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor. Cancer Discov. 2015.07; 5 (7): 730-739. ( PubMed, DOI )

Chen Li Chew, Andrea Lunardi, Federico Gulluni, Daniel T Ruan, Ming Chen, Leonardo Salmena, Michiya Nishino, Antonella Papa, Christopher Ng, Jacqueline Fung, John G Clohessy, Junko Sasaki, Takehiko Sasaki, Roderick T Bronson, Emilio Hirsch, Pier Paolo Pandolfi. In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes. Cancer Discov. 2015.07; 5 (7): 740-751. ( PubMed, DOI )

Laura R H Ip, George Poulogiannis, Felipe Cia Viciano, Junko Sasaki, Satoshi Kofuji, Victoria J Spanswick, Daniel Hochhauser, John A Hartley, Takehiko Sasaki, Christina A Gewinner. Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment. Oncotarget. 2015.04; 6 (12): 10548-10562. ( PubMed, DOI )

Tomonori Ayukawa, Masakazu Akiyama, Jennifer L Mummery-Widmer, Thomas Stoeger, Junko Sasaki, Juergen A Knoblich, Haruki Senoo, Takehiko Sasaki, Masakazu Yamazaki. Dachsous-dependent asymmetric localization of spiny-legs determines planar cell polarity orientation in Drosophila. Cell Rep. 2014.07; 8 (2): 610-621. ( PubMed, DOI )

Yoichiro Fujioka, Masumi Tsuda, Asuka Nanbo, Tomoe Hattori, Junko Sasaki, Takehiko Sasaki, Tadaaki Miyazaki, Yusuke Ohba. A Ca(2+)-dependent signalling circuit regulates influenza A virus internalization and infection. Nat Commun. 2013.11; 4 2763. ( PubMed, DOI )

Hideaki Morishita, Satoshi Eguchi, Hirotaka Kimura, Junko Sasaki, Yuriko Sakamaki, Michael L Robinson, Takehiko Sasaki, Noboru Mizushima. Deletion of autophagy-related 5 (Atg5) and Pik3c3 genes in the lens causes cataract independent of programmed organelle degradation. J. Biol. Chem.. 2013.04; 288 (16): 11436-11447. ( PubMed, DOI )

Shunsuke Takasuga, Yasuo Horie, Junko Sasaki, Ge-Hong Sun-Wada, Nobuyuki Kawamura, Ryota Iizuka, Katsunori Mizuno, Satoshi Eguchi, Satoshi Kofuji, Hirotaka Kimura, Masakazu Yamazaki, Chihoko Horie, Eri Odanaga, Yoshiko Sato, Shinsuke Chida, Kenji Kontani, Akihiro Harada, Toshiaki Katada, Akira Suzuki, Yoh Wada, Hirohide Ohnishi, Takehiko Sasaki. Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine. Proc. Natl. Acad. Sci. U.S.A.. 2013.01; 110 (5): 1726-1731. ( PubMed, DOI )

Hyeon-Cheol Lee, Takao Inoue, Junko Sasaki, Takuya Kubo, Shinji Matsuda, Yasuko Nakasaki, Mitsuharu Hattori, Fumiharu Tanaka, Osamu Udagawa, Nozomu Kono, Toshiki Itoh, Hideo Ogiso, Ryo Taguchi, Makoto Arita, Takehiko Sasaki, Hiroyuki Arai. LPIAT1 regulates arachidonic acid content in phosphatidylinositol and is required for cortical lamination in mice. Mol. Biol. Cell. 2012.12; 23 (24): 4689-4700. ( PubMed, DOI )

G Gregory Neely, Shuan Rao, Michael Costigan, Norbert Mair, Ildiko Racz, Giedre Milinkeviciute, Arabella Meixner, Swetha Nayanala, Robert S Griffin, Inna Belfer, Feng Dai, Shad Smith, Luda Diatchenko, Stefano Marengo, Bernhard J Haubner, Maria Novatchkova, Dustin Gibson, William Maixner, J Andrew Pospisilik, Emilio Hirsch, Ian Q Whishaw, Andreas Zimmer, Vaijayanti Gupta, Junko Sasaki, Yasunori Kanaho, Takehiko Sasaki, Michaela Kress, Clifford J Woolf, Josef M Penninger. Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception. PLoS Genet.. 2012.11; 8 (12): e1003071. ( PubMed, DOI )

Naoki Kobayashi, Kohjiro Ueki, Yukiko Okazaki, Aya Iwane, Naoto Kubota, Mitsuru Ohsugi, Motoharu Awazawa, Masatoshi Kobayashi, Takayoshi Sasako, Kazuma Kaneko, Miho Suzuki, Yoshitaka Nishikawa, Kazuo Hara, Kotaro Yoshimura, Isao Koshima, Susumu Goyama, Koji Murakami, Junko Sasaki, Ryozo Nagai, Mineo Kurokawa, Takehiko Sasaki, Takashi Kadowaki. Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance. Proc. Natl. Acad. Sci. U.S.A.. 2011.04; 108 (14): 5753-5758. ( PubMed, DOI )

Yoichiro Fujioka, Masumi Tsuda, Tomoe Hattori, Junko Sasaki, Takehiko Sasaki, Tadaaki Miyazaki, Yusuke Ohba. The Ras-PI3K signaling pathway is involved in clathrin-independent endocytosis and the internalization of influenza viruses. PLoS ONE. 2011.01; 6 (1): e16324. ( PubMed, DOI )

Nobukatsu Kinoshita, Yasuo Horie, Shigetoshi Ohshima, Yohei Hirai, Takahiro Dohmen, Mario Jin, Tamotsu Matsuhashi, Junko Sasaki, Takehiko Sasaki, Masahiro Iizuka, Hirohide Ohnishi. Epimorphin protects hepatocytes from oxidative stress by inhibiting mitochondrial injury. J. Gastroenterol. Hepatol.. 2011.01; 26 (1): 201-206. ( PubMed, DOI )

Laura A Volpicelli-Daley, Louise Lucast, Liang-Wei Gong, Lijuan Liu, Junko Sasaki, Takehiko Sasaki, Charles S Abrams, Yasunori Kanaho, Pietro De Camilli. Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain. J. Biol. Chem.. 2010.09; 285 (37): 28708-28714. ( PubMed, DOI )

Junko Sasaki, Satoshi Kofuji, Reietsu Itoh, Toshihiko Momiyama, Kiyohiko Takayama, Haruka Murakami, Shinsuke Chida, Yuko Tsuya, Shunsuke Takasuga, Satoshi Eguchi, Ken Asanuma, Yasuo Horie, Kouichi Miura, Elizabeth Michele Davies, Christina Mitchell, Masakazu Yamazaki, Hirokazu Hirai, Tadaomi Takenawa, Akira Suzuki, Takehiko Sasaki. The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death. Nature. 2010.05; 465 (7297): 497-501. ( PubMed, DOI )

Takehiko Sasaki, Shunsuke Takasuga, Junko Sasaki, Satoshi Kofuji, Satoshi Eguchi, Masakazu Yamazaki, Akira Suzuki. Mammalian phosphoinositide kinases and phosphatases. Prog. Lipid Res.. 2009.11; 48 (6): 307-343. ( PubMed, DOI )

Yumiko Anezaki, Shigetoshi Ohshima, Hajime Ishii, Nobukatsu Kinoshita, Takahiro Dohmen, Ei Kataoka, Wataru Sato, Masahiro Iizuka, Takashi Goto, Junko Sasaki, Takehiko Sasaki, Akira Suzuki, Hirohide Ohnishi, Yasuo Horie. Sex difference in the liver of hepatocyte-specific Pten-deficient mice: A model of nonalcoholic steatohepatitis. Hepatol. Res.. 2009.06; 39 (6): 609-618. ( PubMed, DOI )

Hajime Ishii, Yasuo Horie, Shigetoshi Ohshima, Yumiko Anezaki, Nobukatsu Kinoshita, Takahiro Dohmen, Ei Kataoka, Wataru Sato, Takashi Goto, Junko Sasaki, Takehiko Sasaki, Sumio Watanabe, Akira Suzuki, Hirohide Ohnishi. Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice. J. Hepatol.. 2009.03; 50 (3): 562-571. ( PubMed, DOI )

H Kuwana, Y Terada, T Kobayashi, T Okado, J M Penninger, J Irie-Sasaki, T Sasaki, S Sasaki. The phosphoinositide-3 kinase gamma-Akt pathway mediates renal tubular injury in cisplatin nephrotoxicity. Kidney Int.. 2008.02; 73 (4): 430-445. ( PubMed, DOI )

Takehiko Sasaki, Junko Sasaki, Takahiro Sakai, Shunsuke Takasuga, Akira Suzuki. The physiology of phosphoinositides. Biol. Pharm. Bull.. 2007.09; 30 (9): 1599-1604. ( PubMed )

T Sasaki, J Sasaki, K Watanabe, A Suzuki. Non-invasive visualization of the lipid product of class I PI3K in transgenic mouse models. Biochem. Soc. Trans.. 2007.04; 35 (Pt 2): 215-218. ( PubMed, DOI )

Miki Nishio, Ken-ichi Watanabe, Junko Sasaki, Choji Taya, Shunsuke Takasuga, Ryota Iizuka, Tamas Balla, Masakazu Yamazaki, Hiroshi Watanabe, Reietsu Itoh, Shoko Kuroda, Yasuo Horie, Irmgard Förster, Tak W Mak, Hiromichi Yonekawa, Josef M Penninger, Yasunori Kanaho, Akira Suzuki, Takehiko Sasaki. Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat. Cell Biol.. 2007.01; 9 (1): 36-44. ( PubMed, DOI )

Teruhiko Suzuki, Yoshiakira Kanai, Takahiko Hara, Junko Sasaki, Takehiko Sasaki, Michinori Kohara, Tomohiko Maehama, Choji Taya, Hiroshi Shitara, Hiromichi Yonekawa, Michael A Frohman, Takeaki Yokozeki, Yasunori Kanaho. Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development. Mol. Cell. Biol.. 2006.08; 26 (16): 6149-6156. ( PubMed, DOI )

Wataru Sato, Yasuo Horie, Ei Kataoka, Shigetoshi Ohshima, Takahiro Dohmen, Masahiro Iizuka, Junko Sasaki, Takehiko Sasaki, Koichi Hamada, Hiroyuki Kishimoto, Akira Suzuki, Sumio Watanabe. Hepatic gene expression in hepatocyte-specific Pten deficient mice showing steatohepatitis without ethanol challenge. Hepatol. Res.. 2006.04; 34 (4): 256-265. ( PubMed, DOI )

Koichi Hamada, Takehiko Sasaki, Pandelakis A Koni, Miyuki Natsui, Hiroyuki Kishimoto, Junko Sasaki, Nobuyuki Yajima, Yasuo Horie, Go Hasegawa, Makoto Naito, Jun-Ichi Miyazaki, Toshio Suda, Hiroshi Itoh, Kazuwa Nakao, Tak Wah Mak, Toru Nakano, Akira Suzuki. The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev.. 2005.09; 19 (17): 2054-2065. ( PubMed, DOI )

Junko Sasaki, Takehiko Sasaki, Masakazu Yamazaki, Kunie Matsuoka, Choji Taya, Hiroshi Shitara, Shunsuke Takasuga, Miki Nishio, Katsunori Mizuno, Teiji Wada, Hideyuki Miyazaki, Hiroshi Watanabe, Ryota Iizuka, Shuichi Kubo, Shigeo Murata, Tomoki Chiba, Tomohiko Maehama, Koichi Hamada, Hiroyuki Kishimoto, Michael A Frohman, Keiji Tanaka, Josef M Penninger, Hiromichi Yonekawa, Akira Suzuki, Yasunori Kanaho. Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}. J. Exp. Med.. 2005.03; 201 (6): 859-870. ( PubMed, DOI )

Yasuo Horie, Akira Suzuki, Ei Kataoka, Takehiko Sasaki, Koichi Hamada, Junko Sasaki, Katsunori Mizuno, Go Hasegawa, Hiroyuki Kishimoto, Masahiro Iizuka, Makoto Naito, Katsuhiko Enomoto, Sumio Watanabe, Tak Wah Mak, Toru Nakano. Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J. Clin. Invest.. 2004.06; 113 (12): 1774-1783. ( PubMed, DOI )

Junko Irie-Sasaki, Takehiko Sasaki, Josef M Penninger. CD45 regulated signaling pathways. Curr Top Med Chem. 2003.11; 3 (7): 783-796. ( PubMed )

Gavin Y Oudit, Michael A Crackower, Urs Eriksson, Renu Sarao, Ivona Kozieradzki, Takehiko Sasaki, Junko Irie-Sasaki, Dominica Gidrewicz, Vitalyi O Rybin, Teiji Wada, Susan F Steinberg, Peter H Backx, Josef M Penninger. Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure. Circulation. 2003.10; 108 (17): 2147-2152. ( PubMed, DOI )

Michael A Crackower, Gavin Y Oudit, Ivona Kozieradzki, Renu Sarao, Hui Sun, Takehiko Sasaki, Emilio Hirsch, Akira Suzuki, Tetsuo Shioi, Junko Irie-Sasaki, Rajan Sah, Hai-Ying M Cheng, Vitalyi O Rybin, Giuseppe Lembo, Luigi Fratta, Antonio J Oliveira-dos-Santos, Jeffery L Benovic, C Ronald Kahn, Seigo Izumo, Susan F Steinberg, Matthias P Wymann, Peter H Backx, Josef M Penninger. Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell. 2002.09; 110 (6): 737-749. ( PubMed )

Kenji Matsuno, Michio Ichimura, Takao Nakajima, Keiko Tahara, Shigeki Fujiwara, Hiroshi Kase, Junko Ushiki, Neill A Giese, Anjali Pandey, Robert M Scarborough, Nathalie A Lokker, Jin-Chen Yu, Junko Irie, Eiji Tsukuda, Shin-ichi Ide, Shoji Oda, Yuji Nomoto. Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. 1. Synthesis, structure-activity relationship, and biological effects of a new class of quinazoline derivatives. J. Med. Chem.. 2002.07; 45 (14): 3057-3066. ( PubMed )

Takehiko Sasaki, Akira Suzuki, Junko Sasaki, Josef M Penninger. Phosphoinositide 3-kinases in immunity: lessons from knockout mice. J. Biochem.. 2002.04; 131 (4): 495-501. ( PubMed )

R Hirose, H Okumura, A Yoshimatsu, J Irie, Y Onoda, Y Nomoto, H Takai, T Ohno, M Ichimura. KF31327, a new potent and selective inhibitor of cyclic nucleotide phosphodiesterase 5. Eur. J. Pharmacol.. 2001.11; 431 (1): 17-24. ( PubMed )

T Sasaki, J Sasaki-Irie, J M Penninger. New insights into the transmembrane protein tyrosine phosphatase CD45. Int. J. Biochem. Cell Biol.. 2001.11; 33 (11): 1041-1046. ( PubMed )

J M Penninger, J Irie-Sasaki, T Sasaki, A J Oliveira-dos-Santos. CD45: new jobs for an old acquaintance. Nat. Immunol.. 2001.05; 2 (5): 389-396. ( PubMed, DOI )

J Irie-Sasaki, T Sasaki, W Matsumoto, A Opavsky, M Cheng, G Welstead, E Griffiths, C Krawczyk, C D Richardson, K Aitken, N Iscove, G Koretzky, P Johnson, P Liu, D M Rothstein, J M Penninger. CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature. 2001.01; 409 (6818): 349-354. ( PubMed, DOI )

J E Fata, Y Y Kong, J Li, T Sasaki, J Irie-Sasaki, R A Moorehead, R Elliott, S Scully, E B Voura, D L Lacey, W J Boyle, R Khokha, J M Penninger. The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell. 2000.09; 103 (1): 41-50. ( PubMed )

T Sasaki, J Irie-Sasaki, R G Jones, A J Oliveira-dos-Santos, W L Stanford, B Bolon, A Wakeham, A Itie, D Bouchard, I Kozieradzki, N Joza, T W Mak, P S Ohashi, A Suzuki, J M Penninger. Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. Science. 2000.02; 287 (5455): 1040-1046. ( PubMed )

Junko Sasaki, Shogo Yanai, Toshiyoshi Yamamoto, Takehiko Sasaki. Structural and Functional Dissection of Phosphoinositides.. University College London seminar 2023.09.11 London, UK

Yusuke Kiyoki, Takayasu Kato, Sakura Kito, Takashi Matsuzaka, Shin Morioka, Junko Sasaki, Kenichi Makishima, Tatsuhiro Sakamoto, Hidekazu Nishikii, Naoshi Obara, Mamiko Sakata-Yanagimoto, Takehiko Sasaki, Hitoshi Shimano, and Shigeru Chiba. ELOVL6 regulates engraftment of hematopoietic cells through the PI3K pathway.. The 28th European Hematology Association Congress 2023.06.08 Frankfurt, Germany

Aya Toyoshima , Natsuko Noguchi , Junko Sasaki , TakehikoSasaki, Motomu Manabe , Shin-Ichi Osada. Selective blockade of phosphatidylinositol-3 kinaseγ suppresses the development of cutaneoussquamous cell carcinoma. FIRST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING 2023.05.10 Keio Plaza Hotel Tokyo, Japan

Takehiko Sasaki, Junko Sasaki. Phosphoinositide phosphatases in cancer. EMBO WORKSHOP 2022.12.14 Palm Springs, CA, USA

Takayasu Kato, Yusuke Kiyoki, Sakura Kito, Takashi Matsuzaka, Shin Morioka, Junko Sasaki, Tatsuhiro Sakamoto, Hidekazu Nishikii, Naoshi Obara, Mamiko Sakata-Yanagimoto, Takehiko Sasaki, Hitoshi Shimano, and Shigeru Chiba. Elongation of long-chain fatty acids is crucial for hematopoietic stem cell engraftment and leukemia propagation. 64TH ASH ANNUAL MEETING & EXPOSITION 2022.12.10 New Orleans, Louisiana

Takehiko Sasaki, Junko Sasaki. High resolution phosphoinositide profile in pathological samples. FASEB science research conference 2022.11.14 Bangalore, India

Junko Sasaki, Shogo Yanai, Junjie Huang, Junya Hasegawa, Takehiko Sasaki. Premature ovarian insufficiency in mice lacking phosphoinositide-metabolizing enzymes.. The 17th International Symposium of the Institute Network for Biomedical Sciences 2022.10.14 Kanazawa

Takehiko Sasaki, Junko Sasaki. Phosphoinositide dynamics in cancer, Symposium on World Cancer Research. Symposium on World Cancer Research 2022 (SWCR) 2022.05.06 Web (Singapore)

Junya Hasegawa, Lois S. Weisman, Junko Sasaki, Takehiko Sasaki. A new insights into the roles of phosphoinositides in lysosomal function. The 44th Annual Meeting of the Molecular Biology Society of Japan 2021.11.03

Yixin Zhang, Toshiyoshi Yamamoto, Takehiko Sasaki, Junko Sasaki. Biology of phosphoinositide acyl chains. 次世代を担う若手のためのファーマ・バイオフォーラム 2021.08.28

Takehiko Sasaki, Toshiyoshi Yamamoto, Akira Suzuki, Junko Sasaki. Biology of phosphoinositide phosphatases. The 14th International Conference on Protein Phosphatase 2020.12.11 Kobe

成田 伸太郎, 中西 広樹, 松田 芳教, 小泉 淳, 江口 賢史, 高須賀 俊輔, 黄 明国, 井上 高光, 佐々木 純子, 南条 博, 羽渕 友則, 佐々木 雄彦. 腎癌におけるイノシトールリン脂質発現プロファイル. 日本癌学会総会 2019.09.26

成田 伸太郎, 中西 広樹, 松田 芳教, 小泉 淳, 江口 賢史, 高須賀 俊輔, 黄 明国, 井上 高光, 佐々木 純子, 南条 博, 羽渕 友則, 佐々木 雄彦. 腎癌におけるイノシトールリン脂質発現プロファイル(The expression profile of phosphatidylinositol phosphates in clinical renal cell carcinoma). 日本癌学会総会記事 2019.09.01

Junko Sasaki. Molecular mechanisms of phosphoinositide signaling. 9th FAOPS Congress 2019.03.29 Kobe Convention Center

Kimura Hirotaka, Matsuyama Yasushi, Araki Sachiko, Koizumi Atsushi, Kariya Yumi, Takasuga Shunsuke, Eguchi Satoshi, Nakanishi Hiroki, Sasaki Junko, Sasaki Takehiko. 顕微鏡的多発血管炎の病因に対するPI3K-ガンマの遮断による好中球細胞外トラップのin vivo阻害の影響と潜在的な臨床作用(The effect and possible clinical efficacy of in vivo inhibition of neutrophil extracellular traps by blockade of PI3K-gamma on the pathogenesis of microscopic polyangiitis). Modern Rheumatology 2018.05.01

Nagai Takuya, Osada Shin-ichi, Mizusawa Yuta, Suzuki Tomoko, Eguchi Satoshi, Sasaki Junko, Sasaki Takehiko, Manabe Motomu. クラスIIIホスホイノシチド3-キナーゼであるVps34は表皮の恒常性に必須である(Class III phosphoinositide 3-kinase Vps34 is essential for epidermal homeostasis). 日本研究皮膚科学会年次学術大会・総会プログラム 2016.12.01

高鳥 翔, 木村 新伍, 斉藤 貴志, 西道 隆臣, 佐々木 純子, 佐々木 雄彦, 富田 泰輔. アルツハイマー病の遺伝的なリスク要因であるINPP5D/SHIP1の病理学的な役割の分析(Analysis of the pathological role of an Alzheimer's disease genetic risk factor, INPP5D/SHIP1). 日本生化学会大会プログラム・講演要旨集 2016.09.01

中西 広樹, 江口 賢史, 石川 将己, 鈴木 聡, 佐々木 純子, 佐々木 雄彦. リピオドミクスから見えてきた脂質の新機能　基礎から臨床まで　ホスホイノシタイドの新しい解析方法. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 2015.12.01

Sasaki Takehiko, Kimura Hirotaka, Eguchi Satoshi, Sasaki Junko, Mizushima Noboru. 生体膜の構造と機能　分子とそのナノ環境の見地から　クラスIIIPI3Kとphosphatidylinositol 3-phosphateは心筋細胞の構造的および機能的統合性を確実にする(Structure and function of biological membranes: viewed from molecules and their nano-environments　The class III PI3K and phosphatidylinositol 3-phosphate ensure structural and functional integrity of cardiomyocytes). The Journal of Physiological Sciences 2015.03.01

佐々木 雄彦, 高須賀 俊輔, 佐々木 純子, 鈴木 聡. 酸性リン脂質研究の最前線　酸性リン脂質に対して作用する二重特異性ホスファターゼ(Dual specificity phosphatases acting on acidic phospholipids). 日本生化学会大会プログラム・講演要旨集 2013.09.01

森下 英晃, 江口 賢史, 木村 洋貴, 佐々木 純子, 酒巻 有里子, Robinson Michael L., 佐々木 雄彦, 水島 昇. Autophagy-related 5(Atg5)とPik3C3(Vps34)は細胞内小器官の計画的な分解に必須ではないが、それぞれがレンズの質の調節と発達にとって重要である(Autophagy-related 5 (Atg5) and Pik3C3 (Vps34) are not essential for the programmed organelle degradation, but important for the quality control and development of the lens, respectively). 日本生化学会大会プログラム・講演要旨集 2012.12.01

藤岡 容一朗, 津田 真寿美, 服部 ともえ, 佐々木 純子, 佐々木 雄彦, 宮崎 忠昭, 大場 雄介. 染色体・核・遺伝子発現・シグナル伝達　インフルエンザウイルスは、カルシウムシグナル伝達によって、Ras-PI3K-仲介エンドサイトーシスを活性化する(Signal transduction/Chromosome/Cell nucleus/Gene expression　Influenza viruses activate Ras-PI3K-mediated endocytosis via calcium signaling). 日本細胞生物学会大会講演要旨集 2011.05.01

佐々木 純子, 小藤 智史, 鈴木 聡, 佐々木 雄彦. 蛋白質ホスファターゼ　基礎と疾患　脂質ホスファターゼINPP4Aは線条体神経細胞を興奮毒による細胞死から防御する(Protein Phosphatases: Basics and Diseases　The lipid phosphatase INPP4A prevents striatal neurons from excitotoxic death). 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 2010.12.01

藤岡 容一朗, 津田 真寿美, 服部 ともえ, 佐々木 純子, 佐々木 雄彦, 宮崎 忠昭, 大場 雄介. メンブレントラフィック　Ras-PI3Kシグナル経路がエンドサイトーシスとインフルエンザ感染を調節する(Membrane traffic　The Ras-PI3K signaling pathway mediates endocytosis and the incorporation of influenza viruses). 日本細胞生物学会大会講演要旨集 2010.05.01

高須賀 俊輔, 佐々木 純子, 鈴木 聡, 佐々木 雄彦. 生体内でのホスファチジルイノシトール-3,5-二リン酸の生理機能(Physiological function of phosphatidylinositol-3,5-bisphosphate in vivo). 日本細胞生物学会大会講演要旨集 2010.05.01

Anezaki Yumiko, Ohshima Shigetoshi, Ishii Hajime, Kinoshita Nobukatsu, Dohmen Takahiro, Kataoka Ei, Sato Wataru, Iizuka Masahiro, Goto Takashi, Sasaki Junko, Sasaki Takehiko, Suzuki Akira, Ohnishi Hirohide, Horie Yasuo. 肝細胞特異的Pten欠乏マウスの肝臓の性差　非アルコール性脂肪性肝炎モデル(Sex difference in the liver of hepatocyte-specific Pten-deficient mice: A model of nonalcoholic steatohepatitis). Hepatology Research 2009.06.01

高須賀 俊輔, 佐々木 純子, 飯塚 了太, 佐藤 美子, 鈴木 聡, 佐々木 雄彦. 哺乳動物細胞におけるホスファチジルイノシトール3,5-ニリン酸の生理機能(Physiological function of phosphatidylinositol 3,5-bisphosphate in mammalian cells). 日本細胞生物学会大会講演要旨集 2008.06.01

Iizuka Ryota, Takasuga Shunsuke, Sato Yoshiko, Asanuma Ken, Sasaki Junko, Sasaki Takehiko. 哺乳類のIII型ホスファチジルイノシトールリン酸キナーゼは細胞の増殖及び生存に必須ではない(MAMMALIAN TYPE III PHOSPHATIDYLINOSITOL PHOSPHATE KINASE IS DISPENSABLE FOR CELL GROWTH AND SURVIVAL). 秋田医学 2008.06.01

佐々木 雄彦, 高須賀 俊介, 佐々木 純子, 鈴木 聡. PI3Kおよび関連シグナル伝達分子の機能　3-リン酸化ホスホイノシチドの役割(Roles of 3-phosphorylated phosphoinositides). 日本発生生物学会・日本細胞生物学会合同大会要旨集 2007.05.01

Sato Wataru, Horie Yasuo, Kataoka Ei, Ohshima Shigetoshi, Dohmen Takahiro, Iizuka Masahiro, Sasaki Junko, Sasaki Takehiko, Hamada Koichi, Kishimoto Hiroyuki, Suzuki Akira, Watanabe Sumio. 脂肪性肝炎を示す肝細胞特異的Pten欠損マウスにおける非エタノールチャレンジ下の肝遺伝子発現(Hepatic gene expression in hepatocyte-specific Pten deficient mice showing steatohepatitis without ethanol challenge). Hepatology Research 2006.04.01