Personnel Information

写真a

HARA Rintaro


Job title

Junior Associate Professor
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Graduating School 【 display / non-display 】

  • The University of Tokyo, Faculty of Engineering, 2007.03, Graduated

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Campus Career 【 display / non-display 】

  • 2018.04
    -
    2022.05
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Neurology and Neurological Science， Junior Associate Professor
  • 2022.06
    -
    2024.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Neurology and Neurological Science， Project Junior Associate Professor
  • 2024.04
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Neurology and Neurological Science， Junior Associate Professor
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External Career 【 display / non-display 】

  • 2010.04
    -
    2012.03
    The University of Tokyo, Research Fellow, the Japan Society for the Promotion of Science (DC2)
  • 2012.04
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    2013.03
    The University of Tokyo, Project Researcher
  • 2013.04
    -
    2018.03
    Tokyo University of Science, Faculty of Pharmaceutical Sciences, Assistant Professor
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Academic Society Affiliations 【 display / non-display 】

  • THE CHEMICAL SOCIETY OF JAPAN

  • THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH

  • THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN

  • The Nucleic Acids Therapeutics Society of Japan

  • Japan Society of Nucleic Acids Chemistry

  • The Japanese Peptide Society

  • Oligonucleotide therapeutics society

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Academic Activity 【 display / non-display 】

  • 2022.04
    -
    2022.11
    The 49th International Symposium on Nucleic Acids Chemistry Local Organizing Committee
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Qualification Acquired 【 display / non-display 】

  • Hazardous Material Handler (first kind)

  • Organic Solvent Work Chief Person

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Published Papers & Misc 【 display / non-display 】

  1. Juri Hasegawa, Tetsuya Nagata, Kensuke Ihara, Jun Tanihata, Satoe Ebihara, Kie Yoshida-Tanaka, Mitsugu Yanagidaira, Masahiro Ohara, Asuka Sasaki, Miyu Nakayama, Syunsuke Yamamoto, Takashi Ishii, Rintaro Iwata-Hara, Mitsuru Naito, Kanjiro Miyata, Fumika Sakaue, Takanori Yokota. Heteroduplex oligonucleotide technology boosts oligonucleotide splice switching activity of morpholino oligomers in a Duchenne muscular dystrophy mouse model. Nat Commun. 2024.09; 15 (1): 7530. ( PubMed, DOI )

  2. Masahiro Ohara, Tetsuya Nagata, Rintaro Iwata Hara, Kie Yoshida-Tanaka, Nozomi Toide, Kazunori Takagi, Kazuki Sato, Tomoya Takenaka, Masanori Nakakariya, Kenichi Miyata, Yusuke Maeda, Kazuko Toh, Takeshi Wada, Takanori Yokota. DNA/RNA heteroduplex technology with cationic oligopeptide reduces class-related adverse effects of nucleic acid drugs. Mol Ther Nucleic Acids. 2024.09; 35 (3): 102289. ( PubMed, DOI )

  3. Hidetaka Torigoe , Sumire Nakayama , Tomomi Shiraishi , Kazuki Sato , Rintaro Iwata Hara , Takeshi Wada. Development of cationic oligodiaminogalactoses specifically binding to duplex RNA, but not to duplex DNA Thermochimica Acta. 2024.08; 738 179789. ( DOI )

  4. Taiki Matsubayashi, Kotaro Yoshioka, Su Su Lei Mon, Maho Katsuyama, Chunyan Jia, Takao Yamaguchi, Rintaro Iwata Hara, Tetsuya Nagata, Osamu Nakagawa, Satoshi Obika, Takanori Yokota. Favorable efficacy and reduced acute neurotoxicity by antisense oligonucleotides with 2',4'-BNA/LNA with 9-(aminoethoxy)phenoxazine. Mol Ther Nucleic Acids. 2024.06; 35 (2): 102161. ( PubMed, DOI )

  5. Kazutaka Nishina, Kotaro Yoshioka, Takanori Yokota, Rintaro Iwata Hara. Comparison of interaction between antimiR and microRNA versus HDO-antimiR and microRNA by molecular dynamics simulation. Nucleosides Nucleotides Nucleic Acids. 2024.01; 1-16. ( PubMed, DOI )

  6. Yuhei Takahashi, Kiyoshi Kakuta, Yukichi Namioka, Ayumi Igarashi, Taiichi Sakamoto, Rintaro Iwata Hara, Kazuki Sato, Takeshi Wada. Synthesis of P-Modified DNA from Boranophosphate DNA as a Precursor via Acyl Phosphite Intermediates The Journal of Organic Chemistry. 2023.07; 88 (15): 10617-10631. ( DOI )

  7. Motoki Miura, Fumika Sakaue, Hirokazu Matsuno, Kento Morita, Akiko Yoshida, Rintaro Iwata Hara, Ren Nishimura, Yurika Nishida, Mariko Yokogawa, Masanori Osawa, Takanori Yokota. TDP‐43 N‐terminal domain dimerisation or spatial separation by RNA binding decreases its propensity to aggregate FEBS Letters. 2023.06; 597 (12): 1667-1676. ( DOI )

  8. Kazuki Sato, Kazumasa Muramoto, Tomoya Hagio, Rintaro I. Hara, Takeshi Wada. Solid-Phase Synthesis of Glycosyl Phosphate Repeating Units via Glycosyl Boranophosphates as Stable Intermediates Organic Letters. 2023.05; 25 (21): 3927-3931. ( DOI )

  9. Tomomi Shiraishi, Kazuki Sato, Rintaro Iwata Hara, Takeshi Wada. Properties of artificial cationic oligodiaminosaccharides and oligopeptides that bind to A-type oligonucleotide duplexes Nucleosides, Nucleotides & Nucleic Acids. 2023.02; 619-636. ( DOI )

  10. Tomomi Shiraishi, Kazuki Sato, Rintaro Iwata Hara, Takeshi Wada. Synthesis and properties of oligodiaminogalactoses that bind to A-type oligonucleotide duplexes Organic & Biomolecular Chemistry. 2022.09; 20 (42): 8243-8258. ( DOI )

  11. Kazuki Sato, Akie Chiba, Tomomi Shiraishi, Yuki Ogawa, Rintaro Iwata Hara, Takeshi Wada. Solid-phase synthesis of N-trichloroacetyl mannosamine 1-phosphate repeating units mimicking capsular polysaccharide derived from Neisseria meningitidis serotype A Carbohydrate Research. 2022.08; 518 108585. ( DOI )

  12. Hiromasa Matsuda , Hiroaki Ito , Yohei Nukaga , Sho Uehara , Kazuki Sato , Rintaro Iwata Hara , Takeshi Wada. Solid-phase synthesis of oligouridine boranophosphates using the H-boranophosphonate method with 2′-O-(2-cyanoethoxymethyl) protection Tetrahedron Letters. 2021.12; 87 (21): 153526. ( DOI )

  13. Hiromasa Matsuda, Erina Yoshida, Takaaki Shinoda, Kazuki Sato, Rintaro Iwata Hara, Takeshi Wada. Solution-phase synthesis of oligodeoxyribonucleotides using the H-phosphonate method with N-unprotected 5′-phosphite monomers RSC Advances. 2021.11; 11 (60): 38094-38107. ( DOI )

  14. Rintaro Iwata Hara, Takeshi Wada. Inhibition of off-target cleavage by RNase H using an artificial cationic oligosaccharide. Org Biomol Chem. 2021.08; 19 (31): 6865-6870. ( PubMed, DOI )

  15. Kazuki Sato, Tomoya Hagio, Michi Sano, Kazumasa Muramoto, Aya Yaoita, Mihoko Noro, Rintaro Iwata Hara, Takeshi Wada. Solid-Phase Stereocontrolled Synthesis of Oligomeric P-Modified Glycosyl Phosphate Derivatives Using the Oxazaphospholidine Method. ACS Omega. 2021.08; 6 (30): 20026-20041. ( PubMed, DOI )

  16. Atsushi Irie, Kazuki Sato, Rintaro Iwata Hara, Takeshi Wada, Futoshi Shibasaki. An artificial cationic oligosaccharide combined with phosphorothioate linkages strongly improves siRNA stability. Sci Rep. 2020.09; 10 (1): 14845. ( PubMed, DOI )

  17. Rintaro Iwata Hara, Reijiro Yoshino, Yohei Nukaga, Kazuki Sato, Takeshi Wada. Synthesis and properties of DNA oligomers containing stereopure phosphorothioate linkages and C-5 modified deoxyuridine derivatives RSC Advances. 2020.09; 10 (56): 34006-34013. ( DOI )

  18. Wenqing Liao, Sakiko Akahira, Rintaro Iwata Hara, Takeshi Wada, Kosuke Kusamori, Yoshinobu Takakura, Makiya Nishikawa. Enhanced Immunostimulatory Activity of CpG Oligodeoxynucleotide by the Combination of Mannose Modification and Incorporation into Nanostructured DNA. Biol Pharm Bull. 2020.08; 43 (8): 1188-1195. ( PubMed, DOI )

  19. Rintaro Iwata Hara, Kotaro Yoshioka, Takanori Yokota. DNA-RNA Heteroduplex Oligonucleotide for Highly Efficient Gene Silencing. Methods Mol Biol. 2020; 2176 113-119. ( PubMed, DOI )

  20. Kazuki Sato , Hiroki Imai , Tomohito Shuto , Rintaro Iwata Hara , Takeshi Wada. Solid-Phase Synthesis of Phosphate/Boranophosphate Chimeric DNAs using the H-Phosphonate–H-Boranophosphonate Method Journal of Organic Chemistry. 2019.10; 84 (23): 15032-15041. ( DOI )

  21. Kotaro Yoshioka, Taiki Kunieda, Yutaro Asami, Huijia Guo, Haruka Miyata, Kie Yoshida-Tanaka, Yumiko Sujino, Wenying Piao, Hiroya Kuwahara, Kazutaka Nishina, Rintaro Iwata Hara, Tetsuya Nagata, Takeshi Wada, Satoshi Obika, Takanori Yokota. Highly efficient silencing of microRNA by heteroduplex oligonucleotides. Nucleic Acids Res. 2019.08; 47 (14): 7321-7332. ( PubMed, DOI )

  22. Rintaro Iwata Hara, Tatsuya Saito, Tomoki Kogure, Yuka Hamamura, Naoki Uchiyama, Yohei Nukaga, Naoki Iwamoto,Takeshi Wada. Stereocontrolled Synthesis of Boranophosphate DNA by an Oxazaphospholidine Approach and Evaluation of Its Properties Journal of Organic Chemistry. 2019.06; 84 (12): 7971-7983. ( DOI )

  23. Yusuke Maeda, Rintaro Iwata Hara, Kazutaka Nishina, Kie Yoshida-Tanaka, Taiichi Sakamoto, Takanori Yokota and Takeshi Wada. Artificial cationic peptides that increase nuclease resistance of siRNA without disturbing RNAi activity Nucleosides, Nucleotides and Nucleic Acids. 2019.01; 38 (5): 338-348. ( DOI )

  24. Rintaro Iwata Hara, Yusuke Maeda, Haruna Fujimaki, Takeshi Wada. Enhancement in RNase H activity of a DNA/RNA hybrid duplex using artificial cationic oligopeptides Chemical Communications. 2018.08; 54 (61): 8526-8529. ( DOI )

  25. Rintaro Iwata Hara, Aya Yaoita, Katsuya Takeda, Hiroaki Ueki, Ayumu Ishii, Hideyuki Imoto, Satoshi Kobayashi, Michi Sano, Mihoko Noro, Kazuki Sato, Takeshi Wada. Solid-Phase Synthesis of Fluorinated Analogues of Glycosyl 1-Phosphate Repeating Structures from Leishmania using the Phosphoramidite Method ChemistryOpen. 2018.06; 7 439-446. ( DOI )

  26. Rintaro Iwara Hara, Yuta Mitsuhashi, Keita Saito, Yusuke Maeda, Takeshi Wada. Solid-phase synthesis of oligopeptides containing sterically hindered amino acids on non-swellable resin using 3-nitro-1,2,4-triazol-1-yl-tris(pyrrolidin-1-yl)phosphonium hexafluorophosphate (PyNTP) as the condensing reagent ACS Combinatrial Science. 2018.01; 20 132-136. ( DOI )

  27. Rintaro Iwata Hara, Yuki Hisada, Yusuke Maeda, Takanori Yokota, Takeshi Wada. Artificial cationic oligosaccharides for heteroduplex oligonucleotide-type drugs Scientific Reports. 2018; 8 4323. ( DOI )

  28. Rintaro Iwata Hara, Masayuki kageyama, Koichiro Arai, Naoki Uchiyama, Takeshi Wada. Synthesis of 2'-O-monohaloethoxymethyl-modified RNAs and their duplex formation ability RSC Advances. 2017; 7 41297-41303. ( DOI )

  29. Rintaro Iwata Hara, Satoshi Kobayashi, Mihoko Noro, Kazuki Sato, Takeshi Wada. Synthesis and properties of 2-deoxy-2-fluoromannosyl phosphate derivatives Tetrahedron. 2017; 73 4560-4565. ( DOI )

  30. Rintaro Iwata Hara, Yuki Ogawa, Mihoko Noro, Takeshi Wada. Stereocontrolled Synthesis of P-Modified N-Acetylmannosamine-α-1-Phosphate Analogs Chemistry Letters. 2017; 46 1051-1053. ( DOI )

  31. Rintaro Iwata Hara, Yusuke Maeda, Taiichi Sakamoto, Takeshi Wada. Double-stranded RNA-binding artificial cationic oligosaccharides stabilizing siRNAs with a low N/P ratio Organic & Biomolecular Chemistry. 2017; 15 (36): 1710-1717. ( DOI )

  32. Rintaro Iwata, Futoshi Nakayama, Sakie Hirochi, Kazuki Sato, Wenying Piao, Kazutaka Nishina, Takanori Yokota, Takeshi Wada. Synthesis and properties of vitamin E analog-conjugated neomycin for delivery of RNAi drugs to liver cells Bioorganic & Medicinal Chemistry Letters. 2015.02; 25 (4): 815-819. ( DOI )

  33. Tomoko Nishina, Junna Numata, Kazutaka Nishina, Kie Yoshida-Tanaka, Keiko Nitta, Wenying Piao, Rintaro Iwata, Shingo Ito, Hiroya Kuwahara, Takeshi Wada, Hidehiro Mizusawa and Takanori Yokota. Chimeric Antisense Oligonucleotide Conjugated to α-Tocopherol Molecular Therapy - Nucleic Acids. 2015.01; 4 e220. ( DOI )

  34. Rintaro Iwata, Akiko Doi, Yusuke Maeda, Takeshi Wada. Synthesis of oligodiaminomannoses and analysis of their RNA duplex binding properties and their potential application as siRNA-based drugs Organic Biomolecular Chemistry. 2015; 13 9504-9515. ( DOI )

  35. Rintaro Iwata, Kazutaka Nishina, Takanori Yokota, Takeshi Wada. Synthesis and properties of double-stranded RNA-bindable oligodiaminogalactose derivatives conjugated with vitamin E BIOORGANIC & MEDICINAL CHEMISTRY. 2014.02; 22 (4): 1394-1403. ( DOI )

  36. Yusuke Maeda, Rintaro Iwata, Takeshi Wada. Synthesis and properties of cationic oligopeptides with different side chain lengths that bind to RNA duplexes BIOORGANIC & MEDICINAL CHEMISTRY. 2013.04; 21 (7): 1717-1723. ( DOI )

  37. Yusuke Maeda, Rintaro Iwata, Takeshi Wada. Synthesis of Novel Oligocationic Peptides Binding to RNA Duplexes Peptide Science 2012. 2013; 23-24.

  38. Yusuke Maeda, Rintaro Iwata, Takeshi Wada. Synthesis of Novel Oligocationic Peptides which Bind to A-Type Nucleic Acid Duplexes Peptide Science 2011. 2012; 231-232.

  39. Rintaro Iwata, Masafumi Sudo, Kenta Nagafuji, Takeshi Wada. Synthesis of Oligodiaminosaccharides Having alpha-Glycoside Bonds and Their Interactions with Oligonucleotide Duplexes Journal of Organic Chemistry. 2011; 76 (15): 5895-5906. ( DOI )

  40. Rintaro Iwata, Masafumi Sudo, Kenta Nagafuji, Takeshi Wada. Stabilization of A-type nucleic acid duplexes by novel oligodiaminosaccharides Nucleic Acids Symposium Series. 2009.10; 53 (1): 113-114. ( DOI )

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Books etc 【 display / non-display 】

  1. Rintaro Iwata Hara, Takeshi Wada. Handbook of Chemical Biology of Nucleic Acids. Springer Nature， 2022.12 New Molecular Technologies for Oligonucleotide Therapeutics-2: A-Type Nucleic Acid Duplex-Specific Binding Oligocationic Molecules for Oligonucleotide Therapeutics (ISBN : 978-981-16-1313-5)

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Awards & Honors 【 display / non-display 】

  • TMDU President's Young Researchers Award，Tokyo Medical and Dental University，2018.09

  • CSJ Presentation Award 2014，The Chemical Society of Japan，2014.04

  • CSJ Student Presentation Award 2012，The Chemical Society of Japan，2012.04

  • Nucleic Acids Research Award，6th International Symposium on Nucleic Acid Chemistry，2009.10

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