Personnel Information

写真a

SASAKI Takehiko


Job title

Professor

Birth date

1969

Mail Address

The inquiry by e-mail is 《here

Homepage URL

https://sites.google.com/view/sasaki-lab-mri-tmdu-english/home

Graduating School 【 display / non-display

  • The University of Tokyo, Faculty of Pharmaceutical Science, 1992, Graduated

Graduate School 【 display / non-display

  • The University of Tokyo, Graduate School, Division of Pharmaceutical Sciences, Master's Course, 1994, Completed

  • The University of Tokyo, Graduate School, Division of Pharmaceutical Sciences, Doctor's Course, 1997, Completed

Campus Career 【 display / non-display

  • 2018.03
    -
    Now
    Tokyo Medical and Dental University, Medical Research Institute, Pathophysiology, -, Professor
  • 2018.04
    -
    2019.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, -, Lipid Biology, Professor
  • 2018.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, -, -, Professor
  • 2019.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, -, Lipid Biology, Professor

External Career 【 display / non-display

  • 2003.05
    -
    2004.10
    , Project Associate Professor
  • 2004.11
    -
    2018.02
    , Professor
 

Published Papers & Misc 【 display / non-display

  1. Junko Sasaki, Satoshi Kofuji, Reietsu Itoh, Toshihiko Momiyama, Kiyohiko Takayama, Haruka Murakami, Shinsuke Chida, Yuko Tsuya, Shunsuke Takasuga, Satoshi Eguchi, Ken Asanuma, Yasuo Horie, Kouichi Miura, Elizabeth Michele Davies, Christina Mitchell, Masakazu Yamazaki, Hirokazu Hirai, Tadaomi Takenawa, Akira Suzuki, Takehiko Sasaki. The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death. Nature. 2010.05; 465 (7297): 497-501. ( PubMed, DOI )

  2. J Irie-Sasaki, T Sasaki, W Matsumoto, A Opavsky, M Cheng, G Welstead, E Griffiths, C Krawczyk, C D Richardson, K Aitken, N Iscove, G Koretzky, P Johnson, P Liu, D M Rothstein, J M Penninger. CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature. 2001.01; 409 (6818): 349-354. ( PubMed, DOI )

  3. T Sasaki, J Irie-Sasaki, R G Jones, A J Oliveira-dos-Santos, W L Stanford, B Bolon, A Wakeham, A Itie, D Bouchard, I Kozieradzki, N Joza, T W Mak, P S Ohashi, A Suzuki, J M Penninger. Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. Science. 2000.02; 287 (5455): 1040-1046. ( PubMed )

  4. Satoshi Kofuji, Hirotaka Kimura, Hiroki Nakanishi, Hiroshi Nanjo, Shunsuke Takasuga, Hui Liu, Satoshi Eguchi, Ryotaro Nakamura, Reietsu Itoh, Noriko Ueno, Ken Asanuma, Mingguo Huang, Atsushi Koizumi, Tomonori Habuchi, Masakazu Yamazaki, Akira Suzuki, Junko Sasaki, Takehiko Sasaki. INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor. Cancer Discov. 2015.07; 5 (7): 730-739. ( PubMed, DOI )

  5. Miki Nishio, Ken-ichi Watanabe, Junko Sasaki, Choji Taya, Shunsuke Takasuga, Ryota Iizuka, Tamas Balla, Masakazu Yamazaki, Hiroshi Watanabe, Reietsu Itoh, Shoko Kuroda, Yasuo Horie, Irmgard Förster, Tak W Mak, Hiromichi Yonekawa, Josef M Penninger, Yasunori Kanaho, Akira Suzuki, Takehiko Sasaki. Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat. Cell Biol.. 2007.01; 9 (1): 36-44. ( PubMed, DOI )

  6. Nishio Miki, To Yoko, Maehama Tomohiko, Aono Yukari, Otani Junji, Hikasa Hiroki, Kitagawa Akihiro, Mimori Koshi, Sasaki Takehiko, Nishina Hiroshi, Toyokuni Shinya, Lydon John P., Nakao Kazuwa, Mak Tak Wah, Kiyono Tohru, Katabuchi Hidetaka, Tashiro Hironori, Suzuki Akira. Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice(和訳中) Cancer Science. 2020.10; 111 (10): 3576-3587. ( ichushi )

  7. Yamamoto Eiji, Sasaki Junko, Sasaki Takehiko, Sansom Mark S. P.. Effect of lipid quality on the association of membrane bound proteins with phosphoinositidecontaining membranes(和訳中) 生物物理. 2020.08; 60 (Suppl.1-2): S225. ( ichushi )

  8. Nishio M, To Y, Maehama T, Aono Y, Otani J, Hikasa H, Kitagawa A, Mimori K, Sasaki T, Nishina H, Toyokuni S, Lydon JP, Nakao K, Wah Mak T, Kiyono T, Katabuchi H, Tashiro H, Suzuki A. Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice. Cancer science. 2020.07; ( PubMed, DOI )

  9. Fujioka Yoichiro, Satoh Aya O., Horiuchi Kosui, Fujioka Mari, Tsutsumi Kaori, Sasaki Junko, Nepal Prabha, Kashiwagi Sayaka, Paudel Sarad, Nishide Shinya, Nanbo Asuka, Sasaki Takehiko, Ohba Yusuke. A Peptide Derived from Phosphoinositide 3-kinase Inhibits Endocytosis and Influenza Virus Infection(和訳中) Cell Structure and Function. 2019.12; 44 (1-2): 61-74. ( ichushi )

  10. Kawai T, Miyata H, Nakanishi H, Sakata S, Morioka S, Sasaki J, Watanabe M, Sakimura K, Fujimoto T, Sasaki T, Ikawa M, Okamura Y. Polarized PtdIns(4,5)P<sub>2</sub> distribution mediated by a voltage-sensing phosphatase (VSP) regulates sperm motility. Proceedings of the National Academy of Sciences of the United States of America. 2019.11; ( PubMed, DOI )

  11. McCormick Barry, Craig Helen E., Chu Julia Y., Carlin Leo M., Canel Marta, Wollweber Florian, Toivakka Matilda, Michael Melina, Astier Anne L., Norton Laura, Lilja Johanna, Felton Jennifer M., Sasaki Takehiko, Ivaska Johanna, Hers Ingeborg, Dransfield Ian, Rossi Adriano G., Vermeren Sonja. A Negative Feedback Loop Regulates Integrin Inactivation and Promotes Neutrophil Recruitment to Inflammatory Sites JOURNAL OF IMMUNOLOGY. 2019.09; 203 (6): 1579-1588. ( PubMed, DOI )

  12. Koizumi Atsushi, Narita Shintaro, Nakanishi Hiroki, Ishikawa Masaki, Eguchi Satoshi, Kimura Hirotaka, Takasuga Shunsuke, Huang Mingguo, Inoue Takamitsu, Sasaki Junko, Yoshioka Toshiaki, Habuchi Tomonori, Sasaki Takehiko. Increased fatty acyl saturation of phosphatidylinositol phosphates in prostate cancer progression SCIENTIFIC REPORTS. 2019.09; 9 (1): 13257. ( PubMed, DOI )

  13. 成田 伸太郎, 中西 広樹, 松田 芳教, 小泉 淳, 江口 賢史, 高須賀 俊輔, 黄 明国, 井上 高光, 佐々木 純子, 南条 博, 羽渕 友則, 佐々木 雄彦. 腎癌におけるイノシトールリン脂質発現プロファイル(The expression profile of phosphatidylinositol phosphates in clinical renal cell carcinoma) 日本癌学会総会記事. 2019.09; 78回 P-1154. ( ichushi )

  14. Kawai Takafumi, Miyata Haruhiko, Nakanishi Hiroki, Sakata Souhei, Okochi Yoshifumi, Watanabe Masahiko, Sakimura Kenji, Sasaki Takehiko, Ikawa Masahito, Okamura Yasushi. Regulation of cell functions by phosphoinositides Functional analysis of voltage-sensing phosphatase in mouse sperm(和訳中) The Journal of Physiological Sciences. 2019.06; 69 (Suppl.1): S36. ( ichushi )

  15. Sasaki Junko, Eguchi Satoshi, Nakanishi Hiroki, Sasaki Takehiko. Regulation of cell functions by phosphoinositides Molecular mechanisms of phosphoinositide signaling(和訳中) The Journal of Physiological Sciences. 2019.06; 69 (Suppl.1): S36. ( ichushi )

  16. Nishio Miki, Miyachi Yousuke, Otani Junji, Tane Shoji, Omori Hirofumi, Ueda Fumihito, Togashi Hideru, Sasaki Takehiko, Mak Tak Wah, Nakao Kazuwa, Fujita Yasuyuki, Nishina Hiroshi, Maehama Tomohiko, Suzuki Akira. Hippo pathway controls cell adhesion and context-dependent cell competition to influence skin engraftment efficiency FASEB JOURNAL. 2019.04; 33 (4): 5548-5560. ( PubMed, DOI )

  17. Fujioka Y, Satoh AO, Horiuchi K, Fujioka M, Tsutsumi K, Sasaki J, Nepal P, Kashiwagi S, Paudel S, Nishide S, Nanbo A, Sasaki T, Ohba Y. A Peptide Derived from Phosphoinositide 3-kinase Inhibits Endocytosis and Influenza Virus Infection. Cell structure and function. 2019.04; 44 (1): 61-74. ( PubMed, DOI )

  18. Takemasu S, Ito M, Morioka S, Nigorikawa K, Kofuji S, Takasuga S, Eguchi S, Nakanishi H, Matsuoka I, Sasaki J, Sasaki T, Hazeki K. Lysophosphatidylinositol-acyltransferase-1 is involved in cytosolic Ca<sup>2+</sup> oscillations in macrophages. Genes to cells : devoted to molecular & cellular mechanisms. 2019.03; ( PubMed, DOI )

  19. Fujioka Yoichiro, Satoh Aya O., Horiuchi Kosui, Fujioka Mari, Tsutsumi Kaori, Sasaki Junko, Nepal Prabha, Kashiwagi Sayaka, Paudel Sarad, Nishide Shinya, Nanbo Asuka, Sasaki Takehiko, Ohba Yusuke. A Peptide Derived from Phosphoinositide 3-kinase Inhibits Endocytosis and Influenza Virus Infection CELL STRUCTURE AND FUNCTION. 2019; 44 (1): 61-74.

  20. 小泉 淳, 成田 伸太郎, 中西 広樹, 奈良 健平, 神田 壮平, 沼倉 一幸, 黄 明国, 齋藤 満, 井上 高光, 佐藤 滋, 吉岡 年明, 羽渕 友則, 佐々木 雄彦. 前立腺癌におけるホスファチジルイノシトールリン酸プロファイルの解析(Phosphatidylinositol phosphate profiles in pre-clinical and clinical prostate cancer) 日本癌学会総会記事. 2018.09; 77回 1444. ( ichushi )

  21. Hirotaka Kimura, Yasushi Matsuyama, Sachiko Araki, Atsushi Koizumi, Yumi Kariya, Shunsuke Takasuga, Satoshi Eguchi, Hiroki Nakanishi, Junko Sasaki, Takehiko Sasaki. The effect and possible clinical efficacy of in vivo inhibition of neutrophil extracellular traps by blockade of PI3K-gamma on the pathogenesis of microscopic polyangiitis. Mod Rheumatol. 2018.05; 28 (3): 530-541. ( PubMed, DOI )

  22. Hideki Makinoshima, Shigeki Umemura, Ayako Suzuki, Hiroki Nakanishi, Ami Maruyama, Hibiki Udagawa, Sachiyo Mimaki, Shingo Matsumoto, Seiji Niho, Genichiro Ishii, Masahiro Tsuboi, Atsushi Ochiai, Hiroyasu Esumi, Takehiko Sasaki, Koichi Goto, Katsuya Tsuchihara. Metabolic Determinants of Sensitivity to Phosphatidylinositol 3-Kinase Pathway Inhibitor in Small-Cell Lung Carcinoma. Cancer Res.. 2018.05; 78 (9): 2179-2190. ( PubMed, DOI )

  23. Kimura Hirotaka, Matsuyama Yasushi, Araki Sachiko, Koizumi Atsushi, Kariya Yumi, Takasuga Shunsuke, Eguchi Satoshi, Nakanishi Hiroki, Sasaki Junko, Sasaki Takehiko. 顕微鏡的多発血管炎の病因に対するPI3K-ガンマの遮断による好中球細胞外トラップのin vivo阻害の影響と潜在的な臨床作用(The effect and possible clinical efficacy of in vivo inhibition of neutrophil extracellular traps by blockade of PI3K-gamma on the pathogenesis of microscopic polyangiitis) Modern Rheumatology. 2018.05; 28 (3): 530-541. ( ichushi )

  24. Shin Morioka, Kiyomi Nigorikawa, Eri Okada, Yoshimasa Tanaka, Yoshihiro Kasuu, Miho Yamada, Satoshi Kofuji, Shunsuke Takasuga, Hiroki Nakanishi, Takehiko Sasaki, Kaoru Hazeki. TMEM55a localizes to macrophage phagosomes to downregulate phagocytosis. J. Cell. Sci.. 2018.03; 131 (5): ( PubMed, DOI )

  25. Marc C Liggins, Jessica L Flesher, Sohail Jahid, Priya Vasudeva, Victoria Eby, Shunsuke Takasuga, Junko Sasaki, Takehiko Sasaki, Raymond E Boissy, Anand K Ganesan. PIKfyve regulates melanosome biogenesis. PLoS Genet.. 2018; 14 (3): e1007290. ( PubMed, DOI )

  26. Mingguo Huang, Shintaro Narita, Takamitsu Inoue, Atsushi Koizumi, Mitsuru Saito, Hiroshi Tsuruta, Kazuyuki Numakura, Shigeru Satoh, Hiroshi Nanjo, Takehiko Sasaki, Tomonori Habuchi. Fatty acid binding protein 4 enhances prostate cancer progression by upregulating matrix metalloproteinases and stromal cell cytokine production. Oncotarget. 2017.12; 8 (67): 111780-111794. ( PubMed, DOI )

  27. Mouhannad Malek, Anna Kielkowska, Tamara Chessa, Karen E Anderson, David Barneda, Pınar Pir, Hiroki Nakanishi, Satoshi Eguchi, Atsushi Koizumi, Junko Sasaki, Véronique Juvin, Vladimir Y Kiselev, Izabella Niewczas, Alexander Gray, Alexandre Valayer, Dominik Spensberger, Marine Imbert, Sergio Felisbino, Tomonori Habuchi, Soren Beinke, Sabina Cosulich, Nicolas Le Novère, Takehiko Sasaki, Jonathan Clark, Phillip T Hawkins, Len R Stephens. PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K. Mol. Cell. 2017.11; 68 (3): 566-580.e10. ( PubMed, DOI )

  28. 阿部 史人, 中西 広樹, 北舘 明宏, 池田 翔, 亀岡 吉弘, 高橋 直人, 佐々木 雄彦, 田川 博之. 悪性リンパ腫におけるイノシトールリン脂質プロファイル 日本癌学会総会記事. 2017.09; 76回 P-2236. ( ichushi )

  29. Tagawa Hiroyuki, Abe Fumito, Nakanishi Hiroki, Kitadate Akihiro, Ikeda Sho, Takahashi Naoto, Sasaki Takehiko. 脂質定量解析による悪性リンパ腫の新たな診断マーカーの同定(Phosphatidylinositol phosphates profile reveals novel diagnostic marker(s) in malignant lymphoma) 臨床血液. 2017.09; 58 (9): 1742. ( ichushi )

  30. Yoshiko Iizuka-Hishikawa, Daisuke Hishikawa, Junko Sasaki, Keiyo Takubo, Motohito Goto, Katsuyuki Nagata, Hiroki Nakanishi, Hideo Shindou, Tadashi Okamura, Chizuru Ito, Kiyotaka Toshimori, Takehiko Sasaki, Takao Shimizu. Lysophosphatidic acid acyltransferase 3 tunes the membrane status of germ cells by incorporating docosahexaenoic acid during spermatogenesis. J. Biol. Chem.. 2017.07; 292 (29): 12065-12076. ( PubMed, DOI )

  31. Hideo Shindou, Hideto Koso, Junko Sasaki, Hiroki Nakanishi, Hiroshi Sagara, Koh M Nakagawa, Yoshikazu Takahashi, Daisuke Hishikawa, Yoshiko Iizuka-Hishikawa, Fuyuki Tokumasu, Hiroshi Noguchi, Sumiko Watanabe, Takehiko Sasaki, Takao Shimizu. Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells. J. Biol. Chem.. 2017.07; 292 (29): 12054-12064. ( PubMed, DOI )

  32. Otsubo K., Goto H., Nishio M., Kawamura K., Yanagi S., Nishie W., Sasaki T., Maehama T., Nishina H., Mimori K., Nakano T., Shimizu H., Mak T. W., Nakao K., Nakanishi Y., Suzuki A.. MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation ONCOGENE. 2017.07; 36 (29): 4201-4211. ( DOI )

  33. 黄 明国, 小泉 淳, 井上 高光, 成田 伸太郎, 斉藤 満, 佐藤 滋, 南條 博, 佐々木 雄彦, 羽渕 友則. 高脂肪食下前立腺間質 癌微小環境の活性化と前立腺癌進展における脂肪酸結合分子4(FABP4)の役割 日本泌尿器科学会総会. 2017.04; 105回 OP41-4. ( ichushi )

  34. Matsumoto J, Nakanishi H, Kunii Y, Sugiura Y, Yuki D, Wada A, Hino M, Niwa SI, Kondo T, Waki M, Hayasaka T, Masaki N, Akatsu H, Hashizume Y, Yamamoto S, Sato S, Sasaki T, Setou M, Yabe H. Decreased 16:0/20:4-phosphatidylinositol level in the post-mortem prefrontal cortex of elderly patients with schizophrenia. Scientific reports. 2017.03; 7 45050. ( PubMed, DOI )

  35. Hirotaka Kimura, Satoshi Eguchi, Junko Sasaki, Keiji Kuba, Hiroki Nakanishi, Shunsuke Takasuga, Masakazu Yamazaki, Akiteru Goto, Hiroyuki Watanabe, Hiroshi Itoh, Yumiko Imai, Akira Suzuki, Noboru Mizushima, Takehiko Sasaki. Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy. JCI Insight. 2017.01; 2 (1): e89462. ( PubMed, DOI )

  36. Chen Li Chew, Andrea Lunardi, Federico Gulluni, Daniel T Ruan, Ming Chen, Leonardo Salmena, Michiya Nishino, Antonella Papa, Christopher Ng, Jacqueline Fung, John G Clohessy, Junko Sasaki, Takehiko Sasaki, Roderick T Bronson, Emilio Hirsch, Pier Paolo Pandolfi. In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes. Cancer Discov. 2015.07; 5 (7): 740-751. ( PubMed, DOI )

  37. Laura R H Ip, George Poulogiannis, Felipe Cia Viciano, Junko Sasaki, Satoshi Kofuji, Victoria J Spanswick, Daniel Hochhauser, John A Hartley, Takehiko Sasaki, Christina A Gewinner. Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment. Oncotarget. 2015.04; 6 (12): 10548-10562. ( PubMed, DOI )

  38. Gerald R V Hammond, Shunsuke Takasuga, Takehiko Sasaki, Tamas Balla. The ML1Nx2 Phosphatidylinositol 3,5-Bisphosphate Probe Shows Poor Selectivity in Cells. PLoS ONE. 2015; 10 (10): e0139957. ( PubMed, DOI )

  39. Tomonori Ayukawa, Masakazu Akiyama, Jennifer L Mummery-Widmer, Thomas Stoeger, Junko Sasaki, Juergen A Knoblich, Haruki Senoo, Takehiko Sasaki, Masakazu Yamazaki. Dachsous-dependent asymmetric localization of spiny-legs determines planar cell polarity orientation in Drosophila. Cell Rep. 2014.07; 8 (2): 610-621. ( PubMed, DOI )

  40. Hideaki Morishita, Satoshi Eguchi, Hirotaka Kimura, Junko Sasaki, Yuriko Sakamaki, Michael L Robinson, Takehiko Sasaki, Noboru Mizushima. Deletion of autophagy-related 5 (Atg5) and Pik3c3 genes in the lens causes cataract independent of programmed organelle degradation. J. Biol. Chem.. 2013.04; 288 (16): 11436-11447. ( PubMed, DOI )

  41. Shunsuke Takasuga, Yasuo Horie, Junko Sasaki, Ge-Hong Sun-Wada, Nobuyuki Kawamura, Ryota Iizuka, Katsunori Mizuno, Satoshi Eguchi, Satoshi Kofuji, Hirotaka Kimura, Masakazu Yamazaki, Chihoko Horie, Eri Odanaga, Yoshiko Sato, Shinsuke Chida, Kenji Kontani, Akihiro Harada, Toshiaki Katada, Akira Suzuki, Yoh Wada, Hirohide Ohnishi, Takehiko Sasaki. Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine. Proc. Natl. Acad. Sci. U.S.A.. 2013.01; 110 (5): 1726-1731. ( PubMed, DOI )

  42. Yoichiro Fujioka, Masumi Tsuda, Asuka Nanbo, Tomoe Hattori, Junko Sasaki, Takehiko Sasaki, Tadaaki Miyazaki, Yusuke Ohba. A Ca(2+)-dependent signalling circuit regulates influenza A virus internalization and infection. Nat Commun. 2013; 4 2763. ( PubMed, DOI )

  43. Miki Nishio, Koichi Hamada, Kohichi Kawahara, Masato Sasaki, Fumihito Noguchi, Shuhei Chiba, Kensaku Mizuno, Satoshi O Suzuki, Youyi Dong, Masaaki Tokuda, Takumi Morikawa, Hiroki Hikasa, Jonathan Eggenschwiler, Norikazu Yabuta, Hiroshi Nojima, Kentaro Nakagawa, Yutaka Hata, Hiroshi Nishina, Koshi Mimori, Masaki Mori, Takehiko Sasaki, Tak W Mak, Toru Nakano, Satoshi Itami, Akira Suzuki. Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice. J. Clin. Invest.. 2012.12; 122 (12): 4505-4518. ( PubMed, DOI )

  44. Kazuaki Yoshioka, Kotaro Yoshida, Hong Cui, Tomohiko Wakayama, Noriko Takuwa, Yasuo Okamoto, Wa Du, Xun Qi, Ken Asanuma, Kazushi Sugihara, Sho Aki, Hidekazu Miyazawa, Kuntal Biswas, Chisa Nagakura, Masaya Ueno, Shoichi Iseki, Robert J Schwartz, Hiroshi Okamoto, Takehiko Sasaki, Osamu Matsui, Masahide Asano, Ralf H Adams, Nobuyuki Takakura, Yoh Takuwa. Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function. Nat. Med.. 2012.10; 18 (10): 1560-1569. ( PubMed, DOI )

  45. Tatsuki Kurokawa, Shunsuke Takasuga, Souhei Sakata, Shinji Yamaguchi, Shigeo Horie, Koichi J Homma, Takehiko Sasaki, Yasushi Okamura. 3' Phosphatase activity toward phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] by voltage-sensing phosphatase (VSP). Proc. Natl. Acad. Sci. U.S.A.. 2012.06; 109 (25): 10089-10094. ( PubMed, DOI )

  46. Nobuyuki Kawamura, Ge-Hong Sun-Wada, Minako Aoyama, Akihiro Harada, Shunsuke Takasuga, Takehiko Sasaki, Yoh Wada. Delivery of endosomes to lysosomes via microautophagy in the visceral endoderm of mouse embryos. Nat Commun. 2012; 3 1071. ( PubMed, DOI )

  47. G Gregory Neely, Shuan Rao, Michael Costigan, Norbert Mair, Ildiko Racz, Giedre Milinkeviciute, Arabella Meixner, Swetha Nayanala, Robert S Griffin, Inna Belfer, Feng Dai, Shad Smith, Luda Diatchenko, Stefano Marengo, Bernhard J Haubner, Maria Novatchkova, Dustin Gibson, William Maixner, J Andrew Pospisilik, Emilio Hirsch, Ian Q Whishaw, Andreas Zimmer, Vaijayanti Gupta, Junko Sasaki, Yasunori Kanaho, Takehiko Sasaki, Michaela Kress, Clifford J Woolf, Josef M Penninger. Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception. PLoS Genet.. 2012; 8 (12): e1003071. ( PubMed, DOI )

  48. Masato Sasaki, Kohichi Kawahara, Miki Nishio, Koshi Mimori, Ryunosuke Kogo, Koichi Hamada, Bunsho Itoh, Jia Wang, Yukako Komatsu, Yong Ryoul Yang, Hiroki Hikasa, Yasuo Horie, Takayuki Yamashita, Takehiko Kamijo, Yanping Zhang, Yan Zhu, Carol Prives, Toru Nakano, Tak Wah Mak, Takehiko Sasaki, Tomohiko Maehama, Masaki Mori, Akira Suzuki. Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat. Med.. 2011.07; 17 (8): 944-951. ( PubMed, DOI )

  49. Naoki Kobayashi, Kohjiro Ueki, Yukiko Okazaki, Aya Iwane, Naoto Kubota, Mitsuru Ohsugi, Motoharu Awazawa, Masatoshi Kobayashi, Takayoshi Sasako, Kazuma Kaneko, Miho Suzuki, Yoshitaka Nishikawa, Kazuo Hara, Kotaro Yoshimura, Isao Koshima, Susumu Goyama, Koji Murakami, Junko Sasaki, Ryozo Nagai, Mineo Kurokawa, Takehiko Sasaki, Takashi Kadowaki. Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance. Proc. Natl. Acad. Sci. U.S.A.. 2011.04; 108 (14): 5753-5758. ( PubMed, DOI )

  50. Takehiko Sasaki, Shunsuke Takasuga, Junko Sasaki, Satoshi Kofuji, Satoshi Eguchi, Masakazu Yamazaki, Akira Suzuki. Mammalian phosphoinositide kinases and phosphatases. Prog. Lipid Res.. 2009.11; 48 (6): 307-343. ( PubMed, DOI )

  51. Akihiko Nishikimi, Hideo Fukuhara, Wenjuan Su, Tsunaki Hongu, Shunsuke Takasuga, Hisashi Mihara, Qinhong Cao, Fumiyuki Sanematsu, Motomu Kanai, Hiroshi Hasegawa, Yoshihiko Tanaka, Masakatsu Shibasaki, Yasunori Kanaho, Takehiko Sasaki, Michael A Frohman, Yoshinori Fukui. Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis. Science. 2009.04; 324 (5925): 384-387. ( PubMed, DOI )

  52. Yanfeng Wang, Xinsheng Chen, Lurong Lian, Tang Tang, Timothy J Stalker, Takehiko Sasaki, Yasunori Kanaho, Lawrence F Brass, John K Choi, John H Hartwig, Charles S Abrams. Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation. Proc. Natl. Acad. Sci. U.S.A.. 2008.09; 105 (37): 14064-14069. ( PubMed, DOI )

  53. Tae Inoue-Narita, Koichi Hamada, Takehiko Sasaki, Sachiko Hatakeyama, Sachiko Fujita, Kohichi Kawahara, Masato Sasaki, Hiroyuki Kishimoto, Satoshi Eguchi, Itaru Kojima, Friedrich Beermann, Tetsunori Kimura, Masatake Osawa, Satoshi Itami, Tak Wah Mak, Toru Nakano, Motomu Manabe, Akira Suzuki. Pten deficiency in melanocytes results in resistance to hair graying and susceptibility to carcinogen-induced melanomagenesis. Cancer Res.. 2008.07; 68 (14): 5760-5768. ( PubMed, DOI )

  54. Hirohide Iwasaki, Yoshimichi Murata, Youngjun Kim, Md Israil Hossain, Carolyn A Worby, Jack E Dixon, Thomas McCormack, Takehiko Sasaki, Yasushi Okamura. A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate. Proc. Natl. Acad. Sci. U.S.A.. 2008.06; 105 (23): 7970-7975. ( PubMed, DOI )

  55. Fabien Garçon, Daniel T Patton, Juliet L Emery, Emilio Hirsch, Robert Rottapel, Takehiko Sasaki, Klaus Okkenhaug. CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer. Blood. 2008.02; 111 (3): 1464-1471. ( PubMed, DOI )

  56. Akira Suzuki, Toru Nakano, Tak Wah Mak, Takehiko Sasaki. Portrait of PTEN: messages from mutant mice. Cancer Sci.. 2008.02; 99 (2): 209-213. ( PubMed, DOI )

  57. Yanfeng Wang, Rustem I Litvinov, Xinsheng Chen, Tami L Bach, Lurong Lian, Brian G Petrich, Susan J Monkley, Yasunori Kanaho, David R Critchley, Takehiko Sasaki, Morris J Birnbaum, John W Weisel, John Hartwig, Charles S Abrams. Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes. J. Clin. Invest.. 2008.02; 118 (2): 812-819. ( PubMed, DOI )

  58. Kristy A Horan, Ken-Ichi Watanabe, Anne M Kong, Charles G Bailey, John E J Rasko, Takehiko Sasaki, Christina A Mitchell. Regulation of FcgammaR-stimulated phagocytosis by the 72-kDa inositol polyphosphate 5-phosphatase: SHIP1, but not the 72-kDa 5-phosphatase, regulates complement receptor 3 mediated phagocytosis by differential recruitment of these 5-phosphatases to the phagocytic cup. Blood. 2007.12; 110 (13): 4480-4491. ( PubMed, DOI )

  59. Shigehisa Yanagi, Hiroyuki Kishimoto, Kohichi Kawahara, Takehiko Sasaki, Masato Sasaki, Miki Nishio, Nobuyuki Yajima, Koichi Hamada, Yasuo Horie, Hiroshi Kubo, Jeffrey A Whitsett, Tak Wah Mak, Toru Nakano, Masamitsu Nakazato, Akira Suzuki. Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice. J. Clin. Invest.. 2007.10; 117 (10): 2929-2940. ( PubMed, DOI )

  60. Takehiko Sasaki, Junko Sasaki, Takahiro Sakai, Shunsuke Takasuga, Akira Suzuki. The physiology of phosphoinositides. Biol. Pharm. Bull.. 2007.09; 30 (9): 1599-1604. ( PubMed )

  61. Hiroyuki Kishimoto, Toshiaki Ohteki, Nobuyuki Yajima, Koichi Kawahara, Miyuki Natsui, Satoru Kawarasaki, Koichi Hamada, Yasuo Horie, Yoshiaki Kubo, Seiji Arase, Masaru Taniguchi, Bart Vanhaesebroeck, Tak Wah Mak, Toru Nakano, Shigeo Koyasu, Takehiko Sasaki, Akira Suzuki. The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells. Blood. 2007.04; 109 (8): 3316-3324. ( PubMed, DOI )

  62. G John Ferguson, Laura Milne, Suhasini Kulkarni, Takehiko Sasaki, Simon Walker, Simon Andrews, Tom Crabbe, Peter Finan, Gareth Jones, Shaun Jackson, Montserrat Camps, Christian Rommel, Matthias Wymann, Emilio Hirsch, Phillip Hawkins, Len Stephens. PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis. Nat. Cell Biol.. 2007.01; 9 (1): 86-91. ( PubMed, DOI )

  63. Hiroshi Tsuruta, Hiroyuki Kishimoto, Takehiko Sasaki, Yasuo Horie, Miyuki Natsui, Yoshiko Shibata, Koichi Hamada, Nobuyuki Yajima, Koichi Kawahara, Masato Sasaki, Norihiko Tsuchiya, Katsuhiko Enomoto, Tak Wah Mak, Toru Nakano, Tomonori Habuchi, Akira Suzuki. Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients. Cancer Res.. 2006.09; 66 (17): 8389-8396. ( PubMed, DOI )

  64. Yuya Kunisaki, Akihiko Nishikimi, Yoshihiko Tanaka, Ryosuke Takii, Mayuko Noda, Ayumi Inayoshi, Ken-ichi Watanabe, Fumiyuki Sanematsu, Takehiko Sasazuki, Takehiko Sasaki, Yoshinori Fukui. DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis. J. Cell Biol.. 2006.08; 174 (5): 647-652. ( PubMed, DOI )

  65. Min Zhao, Bing Song, Jin Pu, Teiji Wada, Brian Reid, Guangping Tai, Fei Wang, Aihua Guo, Petr Walczysko, Yu Gu, Takehiko Sasaki, Akira Suzuki, John V Forrester, Henry R Bourne, Peter N Devreotes, Colin D McCaig, Josef M Penninger. Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature. 2006.07; 442 (7101): 457-460. ( PubMed, DOI )

  66. Koichi Hamada, Takehiko Sasaki, Pandelakis A Koni, Miyuki Natsui, Hiroyuki Kishimoto, Junko Sasaki, Nobuyuki Yajima, Yasuo Horie, Go Hasegawa, Makoto Naito, Jun-Ichi Miyazaki, Toshio Suda, Hiroshi Itoh, Kazuwa Nakao, Tak Wah Mak, Toru Nakano, Akira Suzuki. The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev.. 2005.09; 19 (17): 2054-2065. ( PubMed, DOI )

  67. Junko Sasaki, Takehiko Sasaki, Masakazu Yamazaki, Kunie Matsuoka, Choji Taya, Hiroshi Shitara, Shunsuke Takasuga, Miki Nishio, Katsunori Mizuno, Teiji Wada, Hideyuki Miyazaki, Hiroshi Watanabe, Ryota Iizuka, Shuichi Kubo, Shigeo Murata, Tomoki Chiba, Tomohiko Maehama, Koichi Hamada, Hiroyuki Kishimoto, Michael A Frohman, Keiji Tanaka, Josef M Penninger, Hiromichi Yonekawa, Akira Suzuki, Yasunori Kanaho. Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}. J. Exp. Med.. 2005.03; 201 (6): 859-870. ( PubMed, DOI )

  68. Yasuo Horie, Akira Suzuki, Ei Kataoka, Takehiko Sasaki, Koichi Hamada, Junko Sasaki, Katsunori Mizuno, Go Hasegawa, Hiroyuki Kishimoto, Masahiro Iizuka, Makoto Naito, Katsuhiko Enomoto, Sumio Watanabe, Tak Wah Mak, Toru Nakano. Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J. Clin. Invest.. 2004.06; 113 (12): 1774-1783. ( PubMed, DOI )

  69. Teiji Wada, Nicholas Joza, Hai-ying M Cheng, Takehiko Sasaki, Ivona Kozieradzki, Kurt Bachmaier, Toshiaki Katada, Martin Schreiber, Erwin F Wagner, Hiroshi Nishina, Josef M Penninger. MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence. Nat. Cell Biol.. 2004.03; 6 (3): 215-226. ( PubMed, DOI )

  70. Minna Woo, Razqallah Hakem, Caren Furlonger, Anne Hakem, Gordon S Duncan, Takehiko Sasaki, Denis Bouchard, Liwei Lu, Gillian E Wu, Christopher J Paige, Tak W Mak. Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity. Nat. Immunol.. 2003.10; 4 (10): 1016-1022. ( PubMed, DOI )

  71. Michael A Crackower, Gavin Y Oudit, Ivona Kozieradzki, Renu Sarao, Hui Sun, Takehiko Sasaki, Emilio Hirsch, Akira Suzuki, Tetsuo Shioi, Junko Irie-Sasaki, Rajan Sah, Hai-Ying M Cheng, Vitalyi O Rybin, Giuseppe Lembo, Luigi Fratta, Antonio J Oliveira-dos-Santos, Jeffery L Benovic, C Ronald Kahn, Seigo Izumo, Susan F Steinberg, Matthias P Wymann, Peter H Backx, Josef M Penninger. Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell. 2002.09; 110 (6): 737-749. ( PubMed )

  72. Connie Krawczyk, Antonio Oliveira-dos-Santos, Takehiko Sasaki, Emily Griffiths, Pamela S Ohashi, Scott Snapper, Fred Alt, Josef M Penninger. Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity. 2002.03; 16 (3): 331-343. ( PubMed )

  73. T Sasaki, T Wada, H Kishimoto, J Irie-Sasaki, G Matsumoto, T Goto, Z Yao, A Wakeham, T W Mak, A Suzuki, S K Cho, J C Zuniga-Pflucker, A J Oliveira-dos-Santos, T Katada, H Nishina, J M Penninger. The stress kinase mitogen-activated protein kinase kinase (MKK)7 is a negative regulator of antigen receptor and growth factor receptor-induced proliferation in hematopoietic cells. J. Exp. Med.. 2001.09; 194 (6): 757-768. ( PubMed )

  74. A Suzuki, M T Yamaguchi, T Ohteki, T Sasaki, T Kaisho, Y Kimura, R Yoshida, A Wakeham, T Higuchi, M Fukumoto, T Tsubata, P S Ohashi, S Koyasu, J M Penninger, T Nakano, T W Mak. T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity. 2001.05; 14 (5): 523-534. ( PubMed )

  75. J M Penninger, J Irie-Sasaki, T Sasaki, A J Oliveira-dos-Santos. CD45: new jobs for an old acquaintance. Nat. Immunol.. 2001.05; 2 (5): 389-396. ( PubMed, DOI )

  76. N Joza, S A Susin, E Daugas, W L Stanford, S K Cho, C Y Li, T Sasaki, A J Elia, H Y Cheng, L Ravagnan, K F Ferri, N Zamzami, A Wakeham, R Hakem, H Yoshida, Y Y Kong, T W Mak, J C Zúñiga-Pflücker, G Kroemer, J M Penninger. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature. 2001.03; 410 (6828): 549-554. ( PubMed, DOI )

  77. C Bony, S Roche, U Shuichi, T Sasaki, M A Crackower, J Penninger, H Mano, M Pucéat. A specific role of phosphatidylinositol 3-kinase gamma. A regulation of autonomic Ca(2)+ oscillations in cardiac cells. J. Cell Biol.. 2001.02; 152 (4): 717-728. ( PubMed )

  78. S Clément, U Krause, F Desmedt, J F Tanti, J Behrends, X Pesesse, T Sasaki, J Penninger, M Doherty, W Malaisse, J E Dumont, Y Le Marchand-Brustel, C Erneux, L Hue, S Schurmans. The lipid phosphatase SHIP2 controls insulin sensitivity. Nature. 2001.01; 409 (6816): 92-97. ( PubMed, DOI )

  79. C Krawczyk, K Bachmaier, T Sasaki, R G Jones, S B Snapper, D Bouchard, I Kozieradzki, P S Ohashi, F W Alt, J M Penninger. Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity. 2000.10; 13 (4): 463-473. ( PubMed )

  80. J E Fata, Y Y Kong, J Li, T Sasaki, J Irie-Sasaki, R A Moorehead, R Elliott, S Scully, E B Voura, D L Lacey, W J Boyle, R Khokha, J M Penninger. The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell. 2000.09; 103 (1): 41-50. ( PubMed )

  81. K Bachmaier, C Krawczyk, I Kozieradzki, Y Y Kong, T Sasaki, A Oliveira-dos-Santos, S Mariathasan, D Bouchard, A Wakeham, A Itie, J Le, P S Ohashi, I Sarosi, H Nishina, S Lipkowitz, J M Penninger. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature. 2000.01; 403 (6766): 211-216. ( PubMed, DOI )

  82. Q Liu, T Sasaki, I Kozieradzki, A Wakeham, A Itie, D J Dumont, J M Penninger. SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival. Genes Dev.. 1999.04; 13 (7): 786-791. ( PubMed )

  83. A Hakem, T Sasaki, I Kozieradzki, J M Penninger. The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis. J. Exp. Med.. 1999.03; 189 (6): 957-968. ( PubMed )

  84. V Stambolic, A Suzuki, J L de la Pompa, G M Brothers, C Mirtsos, T Sasaki, J Ruland, J M Penninger, D P Siderovski, T W Mak. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell. 1998.10; 95 (1): 29-39. ( PubMed )

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Conference Activities & Talks 【 display / non-display

  1. Takehiko Sasaki, Eiji Yamamoto, Toshiyoshi Yamamoto, Junko Sasaki. Phosphoinositide Fingerprinting in Cancer. TOHOKU FORUM for CREATIVITY Thematic Program “Cancer – from Biology to Acceptance” International Symposium 2: New Technology for Diagnosis and Therapeutics of Cancer 2019.12.02

  2. Junko Sasaki, Eiji Yamamoto, Toshiyoshi Yamamoto, Takehiko Sasaki. Molecular dissection of phosphoinositides. The 14th International Symposium of the Institute Network for Biomedical Sciences 2019 2019.10.03

  3. 山本利義、阿部史人、田川博之、佐々木雄彦. リンパ腫細胞株ホスホイノシタイド脂肪酸組成の多変量解析を用いた抗がん剤感受性予測について. 第18回生命科学研究会 2019.06.28

  4. 佐々木雄彦. 良い脂質、悪い脂質、普通の脂質. 文の京・最先端生命科学講座 第24回 2019.06.28

  5. Takehiko Sasaki, Eiji Yamamoto, Toshiyoshi Yamamoto, Junko Sasaki. Lipoquality of phosphoinositides in biological systems. 60th International Conference on the Bioscience of Lipids 2019.06.17

  6. Junko Sasaki,Satoshi Eguchi,Hiroki Nakanishi,Takehiko Sasaki. Molecular mechanisms of phosphoinositide signaling. 9th Federation of the Asian and Oceanian Physiological Societies Congress 2019.03.27

  7. Takehiko Sasaki, Satoshi Kofuji, Shunsuke Takasuga, Junko Sasaki. The lipid phosphatase INPP4B is a tumor suppressor in the context of PTEN insufficiency. Workshop on Frontiers in Phosphatase Research and Drug Discovery 2018.10.24

  8. 佐々木雄彦. ホスホイノシタイドの異常と疾患. 第176回 東京脂質談話会 2018.10.10

  9. 佐々木雄彦. 細胞膜リン脂質動態の生理と病態:An overview. 第91回日本生化学会大会 2018.09.25

  10. 阿部史人、中西広樹、池田翔、田川博之、佐々木雄彦. イノシトールリン脂質プロファイルに基づく 悪性リンパ腫の新たな治療戦略. 第17回生命科学研究会  2018.06.30

  11. 佐々木 雄彦 (計画班) 青木 淳賢 (分担者) . 膜リン脂質クオリティ分析技術の開発と生命現象への適用. 第4回リポクオリティ領域会議 2018.06.17

  12. 山本詠士、佐々木純子、Mark S.P. Sansom、佐々木雄彦. リポクオリティがプレクストリン相同ドメインと生体膜の相互作用に与える影響. 第60回 日本脂質生化学会 2018.05.31

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Campus class subject 【 display / non-display

  • Themes in Humanities and Social Sciences,2019 - Now