Personnel Information

写真a

KOIKE Hiroyuki


Job title

Associate Professor

Laboratory Address

1-5-45 Yushima, Bunkyo, Tokyo 113-8510 Japan

Mail Address

hiroyuki.koike@tmd.ac.jp

Research Areas, Keywords

Organoid, Single Cell Analysis, iPS Cells, Organogenesis, Aging, Liver, Macrophages, 3D Cell Culture, Stem Cell Biology, Regenerative Medicine

Profile

Hiroyuki Koike is an Associate Professor in the Department of Medical Biochemistry, Tokyo Medical and Dental University, specializing in stem cell biology and developmental biology. He has done post-doctoral work at Stanford University and Cincinnati Children's Hospital Medical Center and has been conducting organoid research using human iPS cells, including creating continuous multi-organ organoids of liver-bile duct-pancreas. In recent years, he has been studying cell-cell interaction by single-cell analysis to clarify the factors that disrupt tissue homeostasis.

Field Introduction URL

https://www.tmd.ac.jp/dept/medicine/mbc/

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Graduating School 【 display / non-display 】

  • Tohoku University, Faculty of Engineering, Department of Applied Chemistry, 2007.03, Graduated

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Graduate School 【 display / non-display 】

  • Tohoku University, Graduate School, Division of Engineering, Department of Biomolecular Engineering, Master's Course, 2009.03, Completed

  • Yokohama City University, Graduate School, Division of Medicine, Doctor's Course, 2014.03, Completed

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Campus Career 【 display / non-display 】

  • 2018.03
    -
    2018.04
    Tokyo Medical and Dental University， Medical Research Institute， Advanced Molecular Medicine， Assistant Professor
  • 2018.05
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    2019.03
    Tokyo Medical and Dental University， Medical Research Institute， Advanced Molecular Medicine， Molecular Cell Biology， Assistant Professor
  • 2023.07
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Matrix， Medical Biochemistry， Associate Professor
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External Career 【 display / non-display 】

  • 2009.04
    -
    2010.03
    Teijin Limited, Material Business, R&D
  • 2014.04
    -
    2015.11
    Stanford University School of Medicine, Institute for Stem Cell Biology and Regenerative Medicine, Postdoctoral Fellow
  • 2015.11
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    2018.02
    Cincinnati Children's Hospital Medical Center, Division of Gastroenterology, Hepatology and Nutrition,, Research Fellow
  • 2019.04
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    2022.03
    Nippon Medical School, Department of Biochemistry and Molecular Biology, Assistant Professor
  • 2022.04
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    2023.06
    Nippon Medical School, Department of Biochemistry and Molecular Biology, Junior Associate Professor
  • 2022.04
    -
    2023.06
    Nippon Medical School, Department of Metabolism and Nutrition, Graduate School of Medicine, Senior Assistant Professor

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Academic Society Affiliations 【 display / non-display 】

  • Japanese Society of Anti-Aging Medicine

  • The Molecular Biology Society of Japan

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Research Areas 【 display / non-display 】

  • Developmental biology

  • Medical biochemistry

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Research Theme 【 display / non-display 】

  • Establishment of a circulating culture system using the metabolic characteristics of organoids, 2022.06 - 2025.03

  • Establishment of a circulating culture system using the metabolic characteristics of organoids, 2022.06 - 2025.03

  • Modeling the link between lipid accumulation and aging using on-chip liver organoids, 2021.11 - 2022.03

  • Single cell analysis for tissue regeneration and lipid metabolism in skeletal muscle, 2021.04 - 2024.03

  • Single cell analysis for tissue regeneration and lipid metabolism in skeletal muscle, 2021.04 - 2024.03

  • Modeling Skeletal Muscle Tissue Regeneration with Stem Cell-Macrophage Interaction, 2020.06 - 2023.03

  • Modeling Skeletal Muscle Tissue Regeneration with Stem Cell-Macrophage Interaction, 2020.06 - 2023.03

  • Analysis of interaction between skeletal muscle satellite cells and macrophages for maintenance of tissue homeostasis, 2019.04 - 2021.03

  • Analysis of interaction between skeletal muscle satellite cells and macrophages for maintenance of tissue homeostasis, 2019.04 - 2021.03

  • Study of the muscle satellite cell-macrophage crosstalk and skeletal muscle regeneration, 2018.08 - 2020.03

  • Study of the muscle satellite cell-macrophage crosstalk and skeletal muscle regeneration, 2018.08 - 2020.03

  • Investigation of spatiotemporal regulation of molecular, cellular, and mechanical basis for organogenesis, 2016.07 - 2019.03

  • Investigation of spatiotemporal regulation of molecular, cellular, and mechanical basis for organogenesis, 2016.07 - 2019.03

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Published Papers & Misc 【 display / non-display 】

  1. Hiroyuki Koike, Kentaro Iwasawa, Rie Ouchi, Mari Maezawa, Kirsten Giesbrecht, Norikazu Saiki, Autumn Ferguson, Masaki Kimura, Wendy L Thompson, James M Wells, Aaron M Zorn, Takanori Takebe. Modelling human hepato-biliary-pancreatic organogenesis from the foregut-midgut boundary. Nature. 2019.10; 574 (7776): 112-116. ( PubMed, DOI )

  2. Takahisa Matsuzaki, Yuma Kawano, Momoka Horikiri, Yuko Shimokawa, Takashi Yamazaki, Nao Okuma, Hiroyuki Koike, Masaki Kimura, Ryuzo Kawamura, Yosuke Yoneyama, Yasuro Furuichi, Fumihiko Hakuno, Shin-Ichiro Takahashi, Seiichiro Nakabayashi, Satoshi Okamoto, Hiromitsu Nakauchi, Hideki Taniguchi, Takanori Takebe, Hiroshi Y Yoshikawa. Preparation of mechanically patterned hydrogels for controlling the self-condensation of cells. STAR Protocols. 2023.07; 4 (3): 102471. ( PubMed, DOI )

  3. Aiko Watanabe, Hiroyuki Koike, Naoki Kumagami, Shigeki Shimba, Ichiro Manabe, Yumiko Oishi. Arntl deficiency in myeloid cells reduces neutrophil recruitment and delays skeletal muscle repair. Scientific Reports. 2023.04; 13 (1): 6747. ( PubMed, DOI )

  4. Rie Ouchi, Hiroyuki Koike. Modeling human liver organ development and diseases with pluripotent stem cell-derived organoids. Frontiers in Cell and Developmental Biology. 2023.02; 11 1133534. ( PubMed, DOI )

  5. Sumio Hayakawa, Atsushi Tamura, Nikita Nikiforov, Hiroyuki Koike, Fujimi Kudo, Yinglan Cheng, Takuro Miyazaki, Marina Kubekina, Tatiana V Kirichenko, Alexander N Orekhov, Nobuhiko Yui, Ichiro Manabe, Yumiko Oishi. Activated cholesterol metabolism is integral for innate macrophage responses by amplifying Myd88 signaling. JCI Insight. 2022.11; 7 (22): e138539. ( PubMed, DOI )

  6. Hiroyuki Koike, Ichiro Manabe, Yumiko Oishi. Mechanisms of cooperative cell-cell interactions in skeletal muscle regeneration. Inflammation and Regeneration. 2022.11; 42 (1): 48. ( PubMed, DOI, ichushi )

  7. Takahisa Matsuzaki, Yuko Shimokawa, Hiroyuki Koike, Masaki Kimura, Yuma Kawano, Nao Okuma, Ryuzo Kawamura, Yosuke Yoneyama, Yasuro Furuichi, Fumihiko Hakuno, Shin-Ichiro Takahashi, Seiichiro Nakabayashi, Satoshi Okamoto, Hiromitsu Nakauchi, Hideki Taniguchi, Takanori Takebe, Hiroshi Y Yoshikawa. Mechanical guidance of self-condensation patterns of differentiating progeny. iScience. 2022.10; 25 (10): 105109. ( PubMed, DOI )

  8. Ryo Yuzawa, Hiroyuki Koike, Ichiro Manabe, Yumiko Oishi. VDR regulates simulated microgravity-induced atrophy in C2C12 myotubes. Scientific Reports. 2022.01; 12 (1): 1377. ( PubMed, DOI )

  9. Lin Liu, Hiroyuki Koike, Takehito Ono, Shinichiro Hayashi, Fujimi Kudo, Atsushi Kaneda, Hiroyuki Kagechika, Ichiro Manabe, Tomoki Nakashima, Yumiko Oishi. Identification of a KLF5-dependent program and drug development for skeletal muscle atrophy. Proceedings of the National Academy of Sciences of the United States of America. 2021.08; 118 (35): e2102895118. ( PubMed, DOI )

  10. Hiroyuki Koike, Kentaro Iwasawa, Rie Ouchi, Mari Maezawa, Masaki Kimura, Asuka Kodaka, Shozo Nishii, Wendy L Thompson, Takanori Takebe. Engineering human hepato-biliary-pancreatic organoids from pluripotent stem cells. Nature Protocols. 2021.02; 16 (2): 919-936. ( PubMed, DOI )

  11. Tadahiro Shinozawa, Masaki Kimura, Yuqi Cai, Norikazu Saiki, Yosuke Yoneyama, Rie Ouchi, Hiroyuki Koike, Mari Maezawa, Ran-Ran Zhang, Andrew Dunn, Autumn Ferguson, Shodai Togo, Kyle Lewis, Wendy L Thompson, Akihiro Asai, Takanori Takebe. High-Fidelity Drug-Induced Liver Injury Screen Using Human Pluripotent Stem Cell-Derived Organoids. Gastroenterology. 2021.02; 160 (3): 831-846.e10. ( PubMed, DOI )

  12. Lu Han, Praneet Chaturvedi, Keishi Kishimoto, Hiroyuki Koike, Talia Nasr, Kentaro Iwasawa, Kirsten Giesbrecht, Phillip C Witcher, Alexandra Eicher, Lauren Haines, Yarim Lee, John M Shannon, Mitsuru Morimoto, James M Wells, Takanori Takebe, Aaron M Zorn. Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis. Nature Communications. 2020.08; 11 (1): 4158. ( PubMed, DOI )

  13. Generation of hepato-biliary-pancreatic organoid from human pluripotent stem cells 2019.11; ( DOI )

  14. Rie Ouchi, Shodai Togo, Masaki Kimura, Tadahiro Shinozawa, Masaru Koido, Hiroyuki Koike, Wendy Thompson, Rebekah A Karns, Christopher N Mayhew, Patrick S McGrath, Heather A McCauley, Ran-Ran Zhang, Kyle Lewis, Shoyo Hakozaki, Autumn Ferguson, Norikazu Saiki, Yosuke Yoneyama, Ichiro Takeuchi, Yo Mabuchi, Chihiro Akazawa, Hiroshi Y Yoshikawa, James M Wells, Takanori Takebe. Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids. Cell Metabolism. 2019.08; 30 (2): 374-384.e6. ( PubMed, DOI )

  15. John Ong, Maria Paola Serra, Joe Segal, Ana-Maria Cujba, Soon Seng Ng, Richard Butler, Val Millar, Stephanie Hatch, Salman Zimri, Hiroyuki Koike, Karen Chan, Andrew Bonham, Michelle Walk, Ty Voss, Nigel Heaton, Ragai Mitry, Anil Dhawan, Daniel Ebner, Davide Danovi, Hiromitsu Nakauchi, S Tamir Rashid. Imaging-Based Screen Identifies Laminin 411 as a Physiologically Relevant Niche Factor with Importance for i-Hep Applications. Stem Cell Reports. 2018.03; 10 (3): 693-702. ( PubMed, DOI )

  16. Hiroyuki Koike, Ran-Ran Zhang, Yasuharu Ueno, Keisuke Sekine, Yun-Wen Zheng, Takanori Takebe, Hideki Taniguchi. Nutritional modulation of mouse and human liver bud growth through a branched-chain amino acid metabolism. Development. 2017.03; 144 (6): 1018-1024. ( PubMed, DOI )

  17. Hiroyuki Koike, Takanori Takebe. Generating Mini-Organs in Culture Current Pathobiology Reports. 2016.06; 4 (2): 59-68. ( DOI )

  18. Takanori Takebe, Masahiro Enomura, Emi Yoshizawa, Masaki Kimura, Hiroyuki Koike, Yasuharu Ueno, Takahisa Matsuzaki, Takashi Yamazaki, Takafumi Toyohara, Kenji Osafune, Hiromitsu Nakauchi, Hiroshi Y Yoshikawa, Hideki Taniguchi. Vascularized and Complex Organ Buds from Diverse Tissues via Mesenchymal Cell-Driven Condensation. Cell Stem Cell. 2015.05; 16 (5): 556-565. ( PubMed, DOI )

  19. Hiroyuki Koike, Rie Ouchi, Yasuharu Ueno, Susumu Nakata, Yuta Obana, Keisuke Sekine, Yun-Wen Zheng, Takanori Takebe, Kyoichi Isono, Haruhiko Koseki, Hideki Taniguchi. Polycomb group protein Ezh2 regulates hepatic progenitor cell proliferation and differentiation in murine embryonic liver. PLoS One. 2014.08; 9 (8): e104776. ( PubMed, DOI )

  20. Ran-Ran Zhang, Takanori Takebe, Leina Miyazaki, Maho Takayama, Hiroyuki Koike, Masaki Kimura, Masahiro Enomura, Yun-Wen Zheng, Keisuke Sekine, Hideki Taniguchi. Efficient hepatic differentiation of human induced pluripotent stem cells in a three-dimensional microscale culture. Methods in Molecular Biology. 2014.08; 1210 131-141. ( PubMed, DOI )

  21. Hiroyuki Koike, Yasuharu Ueno, Takako Naito, Tomoya Shiina, Susumu Nakata, Rie Ouchi, Yuta Obana, Keisuke Sekine, Yun-Wen Zheng, Takanori Takebe, Kyo-ichi Isono, Haruhiko Koseki, Hideki Taniguchi. Ring1B promotes hepatic stem/progenitor cell expansion through simultaneous suppression of Cdkn1a and Cdkn2a in mice. Hepatology. 2014.07; 60 (1): 323-333. ( PubMed, DOI )

  22. R Zhang, T Takebe, K Sekine, H Koike, Y Zheng, H Taniguchi. Identification of proliferating human hepatic cells from human induced pluripotent stem cells. Transplantation Proceedings. 2014.05; 46 (4): 1201-1204. ( PubMed, DOI )

  23. Takanori Takebe, Ran-Ran Zhang, Hiroyuki Koike, Masaki Kimura, Emi Yoshizawa, Masahiro Enomura, Naoto Koike, Keisuke Sekine, Hideki Taniguchi. Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature Protocols. 2014.02; 9 (2): 396-409. ( PubMed, DOI )

  24. Takanori Takebe, Keisuke Sekine, Masahiro Enomura, Hiroyuki Koike, Masaki Kimura, Takunori Ogaeri, Ran-Ran Zhang, Yasuharu Ueno, Yun-Wen Zheng, Naoto Koike, Shinsuke Aoyama, Yasuhisa Adachi, Hideki Taniguchi. Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature. 2013.07; 499 (7459): 481-484. ( PubMed, DOI )

  25. Hiroyuki Koike, Koji Kubota, Keisuke Sekine, Takanori Takebe, Rie Ouchi, Yun-Wen Zheng, Yasuharu Ueno, Naoki Tanigawa, Hideki Taniguchi. Establishment of automated culture system for murine induced pluripotent stem cells. BMC Biotechnology. 2012.11; 12 81. ( PubMed, DOI )

  26. Hiroyuki Koike, Hideki Taniguchi. Characteristics of hepatic stem/progenitor cells in the fetal and adult liver. Journal of Hepato-Biliary-Pancreatic Sciences. 2012.11; 19 (6): 587-593. ( PubMed, DOI )

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Books etc 【 display / non-display 】

  1. Hiroyuki Koike, Tamir Rashid, Takanori Takebe. Reviews in Cell Biology and Molecular Medicine. Wiley‐VCH， 2016.11 Growing Mini‐Organs from Stem Cells (ISBN : 978-3-5276-0090-8)

  2. Ran-Ran Zhang, Hiroyuki Koike, Takanori Takebe. Hyper Bio Assembler for 3D Cellular Systems. Springer， 2015.07 The Visualization of Human Organogenesis from Stem Cells by Recapitulating Multicellular Interactions (ISBN : 978-4-431-55297-0)

  3. Ran-Ran Zhang, Takanori Takebe, Leina Miyazaki, Maho Takayama, Hiroyuki Koike, Masaki Kimura, Masahiro Enomura, Yun-Wen Zheng, Keisuke Sekine, Hideki Taniguchi. Stem Cells and Tissue Repair: Methods and Protocols. Humana Press， 2014.08 Efficient Hepatic Differentiation of Human Induced Pluripotent Stem Cells in a Three-Dimensional Microscale Culture (ISBN : 978-1-4939-1435-7)

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Conference Activities & Talks 【 display / non-display 】

  1. Cell-cell interactions of post-injury muscle regeneration and tissue repair. 2023.09.14

  2. Oishi Yumiko, Koike Hiroyuki. 骨格筋再生を制御するマクロファージの多様性(Macrophage diversity that regulates skeletal muscle regeneration). 日本免疫学会総会・学術集会記録 2021.11.01

  3. Engineering human hepato-biliary-pancreatic organoids from pluripotent stem cells.. 2021.01.26

  4. 劉 琳, 小池 博之, 林 晋一郎, 淺原 弘嗣, 大石 由美子. Zincフィンガー転写因子のKLF5は筋萎縮症の病状形成に関与する. 日本筋学会第5回学術集会 2019.08.03 東京都文京区

  5. Lin Liu, Hiroyuki Koike, Yumiko Oishi. Zn-finger transcription factor Klf5 is involved in the pathogenesis of muscle atrophy in vivo.. The 41st Annual Meeting of the Molecular Biology Society of Japan 2018.11.28

  6. Lin Liu, Hiroyuki Koike, Yumiko Oishi. Zn-finger transcription factor Klf5 is involved in the pathogenesis of muscle atrophy in vivo.. The 41st Annual Meeting of the Molecular Biology Society of Japan 2018.11.28

  7. Hiroyuki Koike. Anterior-posterior gut boundary interaction initiate hepatic specification program from human iPSC.. Endoderm Club Research Seminar 2017.04.18 Cincinnati, OH, USA

  8. Hiroyuki Koike, Takanori Takebe. Sequential boundary interaction initiate multi-organ budding program from iPSC. Digestive Health Center Annual Scientific Retreat 2017.02.28 Cincinnati, OH, USA

  9. Rie Ouchi, Tadahiro Shinozawa, Shodai Togo, Hiroyuki Koike, Takanori Takebe. in vitro human NAFLD model using human iPSC derived liver organoids.. The Japan-US Science Forum in Boston 2016.11.12 Cambridge, MA, USA

  10. Hiroyuki Koike. Modeling early human organogenesis using iPSCs.. Liver Research Round Table Discussion 2016.10.24 Cincinnati, OH, USA

  11. Hiroyuki Koike. Modeling early human organogenesis using iPSCs.. Endoderm Club Research Seminar 2016.05.01 Cincinnati, OH, USA

  12. Hiroyuki Koike. Modeling multi-organ budding from human iPSCs.. Developmental Mechanisms, Organogenesis and Stem Cells Annual Retreat 2016 2016.04.01 College Corner, OH, USA

  13. Yuko Shimokawa, Hiroyuki Koike, Takahisa Matsuzaki, Masahiro Enomura, Masaki Kimura, Seiichiro Nakabayashi, Hiromitsu Nakauchi, Hideki Taniguchi, Takanori Takebe, Hiroshi Y. Yoshikawa. Design of Mechanically Patterned Hydrogel for Directing Organ Bud Self-Formation. Pacifichem 2015 2015.12.15 Honolulu, Hawaii, USA

  14. Yuko Shimokawa, Hiroyuki Koike, Takahisa Matsuzaki, Masahiro Enomura, Masaki Kimura, Seiichiro Nakabayashi, Hiromitsu Nakauchi, Hideki Taniguchi, Takanori Takebe, Hiroshi Y. Yoshikawa. Mechanical Study of Formation of Cell Aggregates on Hydrogel. The 53rd Annual Meeting of the Biophysical Society of Japan 2015.09.13 Kanazawa, Japan

  15. Hiroyuki Koike. Modeling liver organogenesis in culture. Stem Cell Club 2015.06.01 Stanford, CA, USA

  16. Hiroyuki Koike, Ran-Ran Zhang, Yasuharu Ueno, Takanori Takebe, Hideki Taniguchi. Valine supplement stimulates expansion of human iPSC-derived hepatic progenitor cells. The 18th Takeda Science Foundation Symposium on Bioscience 2015.01.15 Osaka, Japan

  17. Susumu Nakata, Yasuharu Ueno, Hiroyuki Koike, Keisuke Sekine, Hideki Taniguchi. Localization of repressive histone marks and target genes dynamically switch through murine hepatic differentiation. The 72nd Annual Meeting of the Japanese Cancer Association 2013.10.03 Yokohama, Japan

  18. Keisuke Sekine, Takanori Takebe, Ran-Ran Zhang, Yasuharu Ueno, Masahiro Enomura, Hiroyuki Koike, Yun-Wen Zheng, Hideki Taniguchi. Generation of hepatic cells from human induced pluripotent stem cells. The 20th Annual Meeting of The Japanese Society for the Research of Hepatic Cells 2013.09.26 Osaka, Japan

  19. Maho Takayama, Takanori Takebe, Reina Miyazaki, Masaki Kimura, Hiroyuki Koike, Masahiro Enomura, Keisuke Sekine, Hideki Taniguchi. A Scalable Microculture For Generating Functional Hepatic Cell Spheroids from Human induced Pluripotent Stem Cells. The 20th Annual Meeting of The Japanese Society for the Research of Hepatic Cells 2013.09.26 Osaka, Japan

  20. Takanori Takebe, Keisuke Sekine, Masahiro Enomura, Hiroyuki Koike, RanRan Zhang, Masaki Kimura, Takunori Ogaeri, Emi Yoshizawa, Fumika Kawamata, Naoto Koike, Yasuharu Ueno, Yun-Wen Zheng, Hideki Taniguchi. Creation of vascularized and functional human liver from an induced pluripotent stem cell-derived organ bud transplant. The 13th Congress of the Asian Society of Transplantation 2013.09.03 Kyoto, Japan

  21. Hiroyuki Koike, Takanori Takebe, Yasuharu Ueno, Hideki Taniguchi. In vitro expansion of self-renewing hepatic stem/progenitor cells by controlling metabolic state. International Society for Stem Cell Research 11th Annual Meeting 2013.06.12 Boston, MA, USA

  22. Takanori Takebe, Keisuke Sekine, Masahiro Enomura, Hiroyuki Koike, Ran-Ran Zhang, Masaki Kimura, Takunori Ogaeri, Naoto Koike, Yasuharu Ueno, Yun-Wen Zheng, Hideki Taniguchi. Vascularized and functional human liver tissue from an induced pluripotent stem cell-derived organ bud transplant. International Society for Stem Cell Research 11th Annual Meeting 2013.06.12 Boston, MA, USA

  23. Rie Ouchi, Yasuharu Ueno, Hiroyuki Koike, Haruhiko Koseki, Hideki Taniguchi. Polycomb group protein Ezh2 regulates the expansion of murine hepatic stem/progenitor cells.. The 71st Annual Meeting of the Japanese Cancer Association 2012.09.19 Sapporo, Japan

  24. Hiroyuki Koike, Yasuharu Ueno, Takako Naito, Rie Ouchi, Haruhiko Koseki, Hideki Taniguchi. Ring1B regulates the expansion of hepatic stem/progenitor cells by the suppression of Cdkn1a and Cdkn2a. The 71st Annual Meeting of the Japanese Cancer Association 2012.09.19 Sapporo, Japan

  25. Hiroyuki Koike, Koji Kubota, Keisuke Sekine, Takanori Takebe, Yun-Wen Zheng, Yasuharu Ueno, Naoki Tanigawa, Hideki Taniguchi. Establishment of automated culture system for induced pluripotent stem cells. 15th International Biotechnology Symposium and Exhibition 2012.09.16 Daegu, Korea

  26. Takanori Takebe, Keisuke Sekine, Masahiro Enomura, Yuka Suzuki, Hiroyuki Koike, Ran-Ran Zhang, Naoto Koike, Yasuharu Ueno, Yun-Wen Zheng, Hideki Taniguchi. Creation of vascularized human organ from induced pluripotent stem cells.. International Society for Stem Cell Research 10th Annual Meeting 2012.06.13 Yokohama, Japan

  27. Rie Ouchi, Yasuharu Ueno, Hiroyuki Koike, Tomoya Shiina, Yuta Obana, Kyoichi Isono, Haruhiko Koseki, Hideki Taniguchi. Role of the polycomb group protein Ezh2 in the murine hepatic stem/progenitor cells.. International Society for Stem Cell Research 10th Annual Meeting 2012.06.13 Yokohama, Japan

  28. Hiroyuki Koike, Yasuharu Ueno, Takako Naito, Tomoya Shiina, Rie Ouchi, Kyoichi Isono, Haruhiko Koseki, Hideki Taniguchi. Polycomb group protein Ring1B regulates proliferation and differentiation of mouse hepatic stem/progenitor cell by repressing cyclin-dependent kinase inhibitors. International Society for Stem Cell Research 10th Annual Meeting 2012.06.13 Yokohama, Japan

  29. Mitsuo Umetsu, Hiroyuki Koike, Takeshi Nakahishi, Izumi Kumagai. Build-up design of artificial antibody via coiled-coil peptide assembly. The 2009 Material Research Society (MRS) Spring Meeting 2009.04.13 San Francisco, CA, USA

  30. Mitsuo Umetsu, Takeshi Nakanishi, Keisuke Tanaka, Hiroyuki Koike, Toshihisa Mizuno, Toshiki Tanaka, Izumi Kumagai. Build-up design of artificial antibody via coiled-coil peptide assembly. The 46th annual meeting of the Biophysical Society of Japan 2008.12.03 Fukuoka, Japan

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Awards & Honors 【 display / non-display 】

  • Medical Research Grant，The Takeda Science Foundation，2020.11

  • TMFC，Japan Foundation for Applied Enzymology，2020.06

  • Maruyama Memorial Research Award，Nippon Medical School，2019.09

  • President's Young Researchers Award，Tokyo Medical and Dental University，2018.09

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Others 【 display / non-display 】

  • World's First Three-Organoid System Opens Doors for Medical Research and Diagnosis，2019.09

    Original Title: Modelling human hepato-biliary-pancreatic organogenesis from the foregut–midgut boundary
    Published in: Nature
    Publish date: Sept. 25, 2019

  • [ヒトiPS 細胞からミニ多臓器(肝臓・胆管・膵臓)の作製に成功]―単一臓器再生,から,多臓器一括創生へのパラダイムシフト!―，2019.09

    掲載誌:Nature
    論文タイトル:Modelling human hepato-biliary-pancreatic organogenesis from the foregut–midgut boundary
    Hiroyuki Koike, Kentaro Iwasawa, Rie Ouchi, Mari Maezawa, Kirsten Giesbrecht, Norikazu Saiki, Autumn Ferguson, Masaki Kimura, Wendy Thompson, James M. Wells, Aaron M. Zorn & Takanori Takebe

  • 必須アミノ酸バリンの代謝,肝臓発生に重要な役割 -iPS細胞からミニ肝臓を安価に大量創出する技術へ期待ー，2017.03

    Development (2017) 144, 1018-1024 doi:10.1242/dev.143032

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Campus class subject 【 display / non-display 】

  • Biochemistry Practice，2023 - Now

  • Biochemistry，2023 - Now

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External class subject 【 display / non-display 】

  • Small Group Learning (SGL)，Nippon Medical School

  • Biochemistry & Molecular Biology，Nippon Medical School

  • Biochemistry Practice，Nippon Medical School

  • Laboratory Assignment，Nippon Medical School

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