Personnel Information

写真a

Masashi Kanayama


Job title

Associate Professor
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Graduate School 【 display / non-display 】

  • Hokkaido University, Graduate School, Division of Medicine, Doctor's Course, 2011.03, Completed

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Campus Career 【 display / non-display 】

  • 2017.06
    -
    2022.04
    Tokyo Medical and Dental University， Medical Research Institute， Advanced Molecular Medicine， Biodefense Research， Assistant Professor
  • 2022.05
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    2023.09
    Tokyo Medical and Dental University， Medical Research Institute， Division of Advanced Pathophysiological Science， Department of Biodefense Research， Assistant Professor
  • 2023.10
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    Now
    Tokyo Medical and Dental University， Medical Research Institute， Division of Advanced Pathophysiological Science， Department of Biodefense Research， Associate Professor
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External Career 【 display / non-display 】

  • 2011.11
    -
    2017.05
    Duke University School of Medicine, Department of Immunology, Postdoctoral associate
  • 2022.10
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    Now
    , Visiting Lecturer
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Research Areas 【 display / non-display 】

  • Hematology and medical oncology

  • Cell biology

  • Immunology

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Published Papers & Misc 【 display / non-display 】

  1. Masashi Kanayama, Yuta Izumi, Megumi Akiyama, Toyoki Hayashi, Koji Atarashi, Axel Roers, Taku Sato, Toshiaki Ohteki. Myeloid-like B cells boost emergency myelopoiesis through IL-10 production during infection JOURNAL OF EXPERIMENTAL MEDICINE. 2023.01; 220 (4): ( PubMed, DOI )

  2. Izumi Y, Kanayama M, Shen Z, Kai M, Kawamura S, Akiyama M, Yamamoto M, Nagao T, Okada K, Kawamata N, Toyota S, Ohteki T. An Antibody-Drug Conjugate That Selectively Targets Human Monocyte Progenitors for Anti-Cancer Therapy. Frontiers in immunology. 2021.02; 12 618081. ( PubMed, DOI )

  3. Chikuma S, Yamanaka S, Nakagawa S, Ueda MT, Hayabuchi H, Tokifuji Y, Kanayama M, Okamura T, Arase H, Yoshimura A. TRIM28 Expression on Dendritic Cells Prevents Excessive T Cell Priming by Silencing Endogenous Retrovirus. Journal of immunology (Baltimore, Md. : 1950). 2021.02; 206 (7): 1528-1539. ( PubMed, DOI )

  4. Liang J, Zhang JJ, Huang HI, Kanayama M, Youssef N, Jin YJ, Reyes EY, Abram CL, Yang S, Lowell CA, Wang D, Shao L, Shinohara ML, Zhang JY, Hammer GE. The ubiquitin-modifying enzyme A20 terminates C-type lectin receptor signals and is a suppressor of host defense against systemic fungal infection. Infection and immunity. 2020.06; 88 (9): ( PubMed, DOI )

  5. Kanayama M, Izumi Y, Yamauchi Y, Kuroda S, Shin T, Ishikawa S, Sato T, Kajita M, Ohteki T. CD86-based analysis enables observation of bona fide hematopoietic responses. Blood. 2020.05; ( PubMed, DOI )

  6. 泉 湧太, 金山 剛士, 秋山 めぐみ, 甲斐 正之, 沈 鐘楚子, 川又 紀彦, 樗木 俊聡. Targeting monocyte lineage-restricted antigen as a novel therapeutic strategy for monocytic leukemia(和訳中) 日本病理学会会誌. 2020.03; 109 (1): 304. ( ichushi )

  7. Kanayama Masashi, Izumi Yuta, Ohteki Toshiaki. Hematopoiesis and Immune Environment　Analysis with an alternative marker for Sca-1 revealed bona fide hematopoietic responses during infection(和訳中) 日本免疫学会総会・学術集会記録. 2019.11; 48 (Proceedings): 1-H. ( ichushi )

  8. Kanayama Masashi, Xu Shengjie, Danzaki Keiko, Gibson Jason R., Inoue Makoto, Gregory Simon G., Shinohara Mari L.. Skewing the population balance between lymphoid and myeloid cells by osteopontin isoforms CYTOKINE. 2017.12; 100 161.

  9. Kanayama Masashi, Xu Shengjie, Gibson Jason R, Inoue Makoto, Gregory Simon G, Shinohara Mari L. Hematopoiesis and immune environments Balancing population sizes of myeloid and lymphoid cells by osteopontin isoforms(和訳中) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): 1-G. ( ichushi )

  10. Masashi Kanayama, Shengjie Xu, Keiko Danzaki, Jason R Gibson, Makoto Inoue, Simon G Gregory, Mari L Shinohara. Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin. Nature Immunology. 2017.07; ( PubMed, DOI )

  11. Keiko Danzaki, Masashi Kanayama, Oscar Alcazar, Mari L Shinohara. Osteopontin has a protective role in prostate tumor development in mice. European journal of immunology. 2016.11; 46 (11): 2669-2678. ( PubMed, DOI )

  12. Masashi Kanayama, Keiko Danzaki, You-Wen He, Mari L Shinohara. Lung inflammation stalls Th17-cell migration en route to the central nervous system during the development of experimental autoimmune encephalomyelitis. Int. Immunol.. 2016.09; 28 (9): 463-469. ( PubMed, DOI )

  13. Masashi Kanayama, Mari L Shinohara. Roles of Autophagy and Autophagy-Related Proteins in Antifungal Immunity. Front Immunol. 2016.02; 7 47. ( PubMed, DOI )

  14. Tsutomu Endo, Koyu Ito, Junko Morimoto, Masashi Kanayama, Daichi Ota, Masahiro Ikesue, Shigeyuki Kon, Daisuke Takahashi, Tomohiro Onodera, Norimasa Iwasaki, Toshimitsu Uede. Syndecan 4 Regulation of the Development of Autoimmune Arthritis in Mice by Modulating B Cell Migration and Germinal Center Formation. Arthritis & rheumatology (Hoboken, N.J.). 2015.09; 67 (9): 2512-2522. ( PubMed, DOI )

  15. Masashi Kanayama, You-Wen He, Mari L Shinohara. The lung is protected from spontaneous inflammation by autophagy in myeloid cells. J. Immunol.. 2015.06; 194 (11): 5465-5471. ( PubMed, DOI )

  16. Masashi Kanayama, Makoto Inoue, Keiko Danzaki, Gianna Hammer, You-Wen He, Mari L Shinohara. Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity. Nature Communications. 2015.01; 6 5779. ( PubMed, DOI )

  17. Daichi Ota, Masashi Kanayama, Yutaka Matsui, Koyu Ito, Naoyoshi Maeda, Goro Kutomi, Koichi Hirata, Toshihiko Torigoe, Noriyuki Sato, Akinori Takaoka, Ann F Chambers, Junko Morimoto, Toshimitsu Uede. Tumor-α9β1 integrin-mediated signaling induces breast cancer growth and lymphatic metastasis via the recruitment of cancer-associated fibroblasts. J. Mol. Med.. 2014.12; 92 (12): 1271-1281. ( PubMed, DOI )

  18. Shigeyuki Kon, Yosuke Nakayama, Naoki Matsumoto, Koyu Ito, Masashi Kanayama, Chiemi Kimura, Hitomi Kouro, Dai Ashitomi, Tadashi Matsuda, Toshimitsu Uede. A novel cryptic binding motif, LRSKSRSFQVSDEQY, in the C-terminal fragment of MMP-3/7-cleaved osteopontin as a novel ligand for α9β1 integrin is involved in the anti-type II collagen antibody-induced arthritis. PLoS ONE. 2014.12; 9 (12): e116210. ( PubMed, DOI )

  19. Tsuyoshi Asano, Norimasa Iwasaki, Shigeyuki Kon, Masashi Kanayama, Junko Morimoto, Akio Minami, Toshimitsu Uede. α9β1 integrin acts as a critical intrinsic regulator of human rheumatoid arthritis. Rheumatology (Oxford). 2014.03; 53 (3): 415-424. ( PubMed, DOI )

  20. Keiko Danzaki, Yutaka Matsui, Masahiro Ikesue, Daichi Ohta, Koyu Ito, Masashi Kanayama, Daisuke Kurotaki, Junko Morimoto, Yoichiro Iwakura, Hideo Yagita, Hiroyuki Tsutsui, Toshimitsu Uede. Interleukin-17A deficiency accelerates unstable atherosclerotic plaque formation in apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol.. 2012.02; 32 (2): 273-280. ( PubMed, DOI )

  21. Yukinori Tsukuda, Norimasa Iwasaki, Naoki Seito, Masashi Kanayama, Naoki Fujitani, Yasuro Shinohara, Yasuhiko Kasahara, Tomohiro Onodera, Koji Suzuki, Tsuyoshi Asano, Akio Minami, Tadashi Yamashita. Ganglioside GM3 has an essential role in the pathogenesis and progression of rheumatoid arthritis. PLoS ONE. 2012.01; 7 (6): e40136. ( PubMed, DOI )

  22. Masashi Kanayama, Junko Morimoto, Yutaka Matsui, Masahiro Ikesue, Keiko Danzaki, Daisuke Kurotaki, Koyu Ito, Toshimichi Yoshida, Toshimitsu Uede. α9β1 integrin-mediated signaling serves as an intrinsic regulator of pathogenic Th17 cell generation. J. Immunol.. 2011.12; 187 (11): 5851-5864. ( PubMed, DOI )

  23. Daisuke Kurotaki, Shigeyuki Kon, Kyeonghwa Bae, Koyu Ito, Yutaka Matsui, Yosuke Nakayama, Masashi Kanayama, Chiemi Kimura, Yoshinori Narita, Takashi Nishimura, Kazuya Iwabuchi, Matthias Mack, Nico van Rooijen, Shimon Sakaguchi, Toshimitsu Uede, Junko Morimoto. CSF-1-dependent red pulp macrophages regulate CD4 T cell responses. J. Immunol.. 2011.02; 186 (4): 2229-2237. ( PubMed, DOI )

  24. Masashi Kanayama, Daisuke Kurotaki, Junko Morimoto, Tsuyoshi Asano, Yutaka Matsui, Yosuke Nakayama, Yoshinari Saito, Koyu Ito, Chiemi Kimura, Norimasa Iwasaki, Koji Suzuki, Tanenobu Harada, Hong Mei Li, Jun Uehara, Tadaaki Miyazaki, Akio Minami, Shigeyuki Kon, Toshimitsu Uede. Alpha9 integrin and its ligands constitute critical joint microenvironments for development of autoimmune arthritis. J. Immunol.. 2009.06; 182 (12): 8015-8025. ( PubMed, DOI )

  25. Koyu Ito, Shigeyuki Kon, Yosuke Nakayama, Daisuke Kurotaki, Yoshinari Saito, Masashi Kanayama, Chiemi Kimura, Hongyan Diao, Junko Morimoto, Yutaka Matsui, Toshimitsu Uede. The differential amino acid requirement within osteopontin in alpha4 and alpha9 integrin-mediated cell binding and migration. Matrix Biol.. 2009.01; 28 (1): 11-19. ( PubMed, DOI )

  26. Yoshinari Saito, Shigeyuki Kon, Yukio Fujiwara, Yosuke Nakayama, Daisuke Kurotaki, Naoki Fukuda, Chiemi Kimura, Masashi Kanayama, Koyu Ito, Hongyan Diao, Yutaka Matsui, Yasuo Komatsu, Eiko Ohtsuka, Toshimitsu Uede. Osteopontin small interfering RNA protects mice from fulminant hepatitis. Hum. Gene Ther.. 2007.12; 18 (12): 1205-1214. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Masashi Kanayama, Toshiaki Ohteki. Myeloid-like B cells protect the host by boosting myelopoiesis during infection. JSICR/MMCB 2023合同シンポジウム 2023.05.25 Wakayama

  2. Kanayama Masashi, Ohteki Toshiaki. B cell: an amplifier of myeloid cell production triggered by infection. 日本免疫学会総会・学術集会記録 2022.12.09

  3. Yuta Izumi, Masashi Kanayama, Toshiaki Ohteki. A Therapeutic Strategy That Selectively Targets Human Monocyte Progenitors for Solid Cancers and Leukemias. 第50回　日本免疫学会学術集会 2021.12.10

  4. Masashi Kanayama, Yuta Izumi, Toshiaki Ohteki. Myeloid-like B cells boost　emergency myelopoiesis during infection. 第50回日本免疫学会学術集会 2021.12.08 奈良

  5. Masashi Kanayama. CD86-based analysis enables identification of hematopoietic progenitors under biological stresses which upregulate interferon. 8th Annual Meeting of the International Cytokine & Interferon Society 2020.11.02

  6. 泉 湧太, 金山 剛士, 秋山 めぐみ, 甲斐 正之, 沈 鐘楚子, 川又 紀彦, 樗木 俊聡. 単球性白血病の新規治療戦略としての単球系制限抗原の標的化(Targeting monocyte lineage-restricted antigen as a novel therapeutic strategy for monocytic leukemia). 日本病理学会会誌 2020.03.01

  7. Kanayama Masashi, Izumi Yuta, Ohteki Toshiaki. 造血と免疫環境　Sca-1に関する他のマーカーの分析から明らかになった感染中のbona fide造血応答(Hematopoiesis and Immune Environment　Analysis with an alternative marker for Sca-1 revealed bona fide hematopoietic responses during infection). 日本免疫学会総会・学術集会記録 2019.11.01

  8. Masashi Kanayama. Balancing population sizes of myeloid and lymphoid cells by osteopontin isoforms. The 46th Annual Meeting of the Japanease Society for Immunology 2017.12.12 Sendai, Japan

  9. Kanayama Masashi, Xu Shengjie, Gibson Jason R., Inoue Makoto, Gregory Simon G., Shinohara Mari L.. 癌免疫療法における免疫応答　Osteopontinアイソフォームによる骨髄細胞とリンパ球細胞の細胞集団サイズのバランス維持(Hematopoiesis and immune environments　Balancing population sizes of myeloid and lymphoid cells by osteopontin isoforms). 日本免疫学会総会・学術集会記録 2017.12.01

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Awards & Honors 【 display / non-display 】

  • Best Presentation Award，2017.12

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Others 【 display / non-display 】

  • A call for action mounts an emergent attack against invaders，2023.02

  • An antibody-drug combo to combat cancer，2021.04

  • How Stress Affects Bone Marrow，2020.06

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