経歴(学内) 【 表示 ／ 非表示 】
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2017年04月-2020年03月東京医科歯科大学 大学院医歯学総合研究科 医歯学系専攻 口腔機能再構築学講座 細菌感染制御学 大学院生
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2020年05月-2021年03月東京医科歯科大学 大学院医歯学総合研究科 医歯学系専攻 口腔機能再構築学講座 細菌感染制御学 特任研究員
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2022年03月-現在東京医科歯科大学 大学院医歯学総合研究科 医歯学系専攻 口腔機能再構築学講座 細菌感染制御学 助教
競争的資金等の研究課題 【 表示 ／ 非表示 】
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シングルセル解析技術によるブルーリ潰瘍起因菌の分離と伝播経路探索
文部科学省/日本学術振興会 : 2023年 - 2025年
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低酸素環境におけるインフラマソーム活性化メカニズムの解明
文部科学省/日本学術振興会
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口腔内細菌による自然免疫活性化が誘導する大腸癌増悪化機構の解明
文部科学省/日本学術振興会
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歯周炎関連細菌が引き起こす多発性硬化症増悪化メカニズムの解明
文部科学省/日本学術振興会
論文・総説 【 表示 ／ 非表示 】
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Suzuki, T; Boonyaleka, K; Okano, T; Iida, T; Yoshida, M; Fukano, H; Hoshino, Y; Iwakura, Y; Ablordey, AS; Ashida, H. Inflammasome-triggered IL-18 controls skin inflammation in the progression of Buruli ulcer PLOS Pathogens. 2023.11; 19 (11): e1011747. ( PubMed, DOI )
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Kotchakorn Boonyaleka, Tokuju Okano, Tamako Iida, Anongwee Leewananthawet, Miwa Sasai, Masahiro Yamamoto, Hiroshi Ashida, Toshihiko Suzuki. Fusobacterium nucleatum infection activates the noncanonical inflammasome and exacerbates inflammatory response in DSS-induced colitis European Journal of Immunology. 2023.08; ( DOI )
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Sumiko Yoshida Masahiro Hatasa Yujin Ohsugi Yosuke Tsuchiya Anhao Liu Hiromi Niimi Kazuki Morita Tsuyoshi Shimohira Naoki Sasaki Shogo Maekawa Takahiko Shiba Tomomitsu Hirota Tokuju Okano Asuka Hirose Rinko Ibi Kanako Noritake Yuki Tomiga Hiroshi Nitta Toshihiko Suzuki Hirokazu Takahashi Naoyuki Miyasaka Takanori Iwata Sayaka Katagiri. Porphyromonas gingivalis Administration Induces Gestational Obesity, Alters Gene Expression in the Liver and Brown Adipose Tissue in Pregnant Mice, and Causes Underweight in Fetuses Frontiers in Cellular and Infection Microbiology. 2022.01;
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Abass A, Okano T, Boonyaleka K, Kinoshita-Daitoku R, Yamaoka S, Ashida H, Suzuki T. Effect of low oxygen concentration on activation of inflammation by Helicobacter pylori Biochemical and Biophysical Research Communications. 2021.05; ( DOI )
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Kinoshita-Daitoku R, Kiga K, Sanada T, Ogura Y, Bo Z, Iida T, Yokomori R, Kuroda E, Tanaka M, Sood A, Suzuki T, Nakai K, Hayashi T, Mimuro H. A bacterial small RNA regulates the adaptation of Helicobacter pylori to the host environment Nature Communications. 2021.04; 12 (1): ( DOI )
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Mototsugu Tanaka, Ryo Kinoshita-Daitoku, Kotaro Kiga, Takahito Sanada , Bo Zhu, Tokuju Okano, Chihiro Aikawa, Tamako Iida, Yoshitoshi Ogura, Tetsuya Hayashi, Koshu Okubo, Miho Kurosawa, Junichi Hirahashi, Toshihiko Suzuki, Ichiro Nakagawa, Masaomi Nangaku, Hitomi Mimuro . Group A Streptococcus establishes pharynx infection by degrading the deoxyribonucleic acid of neutrophil extracellular traps Scientific Reports. 2020.02; 24 (1): ( DOI )
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Kiyonobu Yamamura, Hiroshi Ashida , Tokuju Okano , Ryo Kinoshita-Daitoku, Shiho Suzuki, Kaori Ohtani, Miwako Hamagaki , Tohru Ikeda , Toshihiko Suzuki 1. Inflammasome Activation Induced by Perfringolysin O of Clostridium perfringens and Its Involvement in the Progression of Gas Gangrene Frontiers in Microbiology. 2019.10;
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Anongwee Leewananthaweta,, Shinichi Arakawa, Tokuju Okano, Ryo Daitoku Kinoshita, Hiroshi Ashida, Yuichi Izumi and Toshihiko Suzuki. Ozone ultrafine bubble water induces the cellular signaling involved in oxidative stress responses in human periodontal ligament fibroblasts SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS. 2019.05; 20 (1): 589-598. ( DOI )
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Okano T, Ashida H, Suzuki S, Shoji M, Nakayama K, Suzuki T. Porphyromonas gingivalis triggers NLRP3-mediated inflammasome activation in macrophages in a bacterial gingipains-independent manner. European Journal of Imunology. 2018.12; ( DOI )
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Yuhei Maruzuru, Takeshi Ichinohe, Ryota Sato, Kensuke Miyake, Tokuju Okano, Toshihiko Suzuki, Takumi Koshiba, Naoto Koyanagi, Shumpei Tsuda, Mizuki Watanabe, Jun Arii, Akihisa Kato, Yasushi Kawaguch. Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication Cell Host & Microbe. 2018.02; 23 (2): 254-265.
講演・口頭発表等 【 表示 ／ 非表示 】
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Kotchakorn Boonyaleka, Tokuju Okano, Toshihiko Suzuki. Fusobacterium nucleatum infection activates the non-canonical inflammasome pathway to exacerbate inflammatory response in acute colitis mice.. The 51st Annual Meeting of the Japanese Society for Immunology 2022.12.08 Kumamoto-Jo Hall
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Tokuju Okano, Toshihiko Suzuki. Porphyromnas gingivalis infection triggers enhancement of severity for EAE following inflammasome activation in macrophages.. The 51st Annual Meeting of the Japanese Society for Immunology 2022.12.07 Kumamoto-Jo Hall
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Boonyaleka KOTCHAKORN, Tokuju OKANO, Toshihiko SUZUKI. Fusobacterium nucleatum infection induces non-canonical inflammasome activation to exacerbate inflammation in acute colitis mice.. The 87th Annual Meeting of Stomatological Society, Japan 2022.12.03 Tokyo Medical and Dental University
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岡野 徳壽, 鈴木 敏彦. P.gingivalisの口腔内感染によるマウス神経症状の増悪. 第96回日本細菌学会総会 2023.03.16 姫路
受賞学術賞 【 表示 ／ 非表示 】
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Tadamitsu Kishimoto International Travel Award，日本免疫学会，2019年09月
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若手奨励賞，日本細菌学会関東支部，2017年09月