Hiroshi Ashida, Tokuju Okano, Tamako Iida, Poramed Onsoi, Chihiro Sasakawa, and Toshihiko Suzuki. Shigella type III secretion system effectors fine-tune host inflammation and cell death EMBO Journal. 2025.09;

Hsu Chen-Wei, Okano Tokuju, Niinuma Yuiko, Leewananthawet Anongwee, Iida Tamako, Onsoi Poramed, Boonyaleka Kotchakorn, Ashida Hiroshi, Suzuki Toshihiko. カスパーゼ-4とのNLRP3の複合体形成はTannerella forsythia感染によるインフラマソーム活性化のために必須である(A complex of NLRP3 with caspase-4 is essential for inflammasome activation by Tannerella forsythia infection) International Immunology. 2025.05; 37 (5): 261-271. ( ichushi )

Suzuki, T; Boonyaleka, K; Okano, T; Iida, T; Yoshida, M; Fukano, H; Hoshino, Y; Iwakura, Y; Ablordey, AS; Ashida, H. Inflammasome-triggered IL-18 controls skin inflammation in the progression of Buruli ulcer PLOS Pathogens. 2023.11; 19 (11): e1011747. ( PubMed, DOI )

Sumiko Yoshida Masahiro Hatasa Yujin Ohsugi Yosuke Tsuchiya Anhao Liu Hiromi Niimi Kazuki Morita Tsuyoshi Shimohira Naoki Sasaki Shogo Maekawa Takahiko Shiba Tomomitsu Hirota Tokuju Okano Asuka Hirose Rinko Ibi Kanako Noritake Yuki Tomiga Hiroshi Nitta Toshihiko Suzuki Hirokazu Takahashi Naoyuki Miyasaka Takanori Iwata Sayaka Katagiri. Porphyromonas gingivalis Administration Induces Gestational Obesity, Alters Gene Expression in the Liver and Brown Adipose Tissue in Pregnant Mice, and Causes Underweight in Fetuses Frontiers in Cellular and Infection Microbiology. 2022.01;

Kobayashi J, Arisaka Y, Yui N, Yamato M, Okano T. Preservation of heparin-binding EGF-like growth factor activity on heparin-modified poly(N-isopropylacrylamide)-grafted surfaces. RSC advances. 2021.11; 11 (59): 37225-37232. ( PubMed, DOI )

Abass A, Okano T, Boonyaleka K, Kinoshita-Daitoku R, Yamaoka S, Ashida H, Suzuki T. Effect of low oxygen concentration on activation of inflammation by Helicobacter pylori Biochemical and Biophysical Research Communications. 2021.05; ( DOI )

Kinoshita-Daitoku R, Kiga K, Sanada T, Ogura Y, Bo Z, Iida T, Yokomori R, Kuroda E, Tanaka M, Sood A, Suzuki T, Nakai K, Hayashi T, Mimuro H. A bacterial small RNA regulates the adaptation of Helicobacter pylori to the host environment Nature Communications. 2021.04; 12 (1): ( DOI )

Mototsugu Tanaka, Ryo Kinoshita-Daitoku, Kotaro Kiga, Takahito Sanada , Bo Zhu, Tokuju Okano, Chihiro Aikawa, Tamako Iida, Yoshitoshi Ogura, Tetsuya Hayashi, Koshu Okubo, Miho Kurosawa, Junichi Hirahashi, Toshihiko Suzuki, Ichiro Nakagawa, Masaomi Nangaku, Hitomi Mimuro . Group A Streptococcus establishes pharynx infection by degrading the deoxyribonucleic acid of neutrophil extracellular traps Scientific Reports. 2020.02; 24 (1): ( DOI )

Kiyonobu Yamamura, Hiroshi Ashida , Tokuju Okano , Ryo Kinoshita-Daitoku, Shiho Suzuki, Kaori Ohtani, Miwako Hamagaki , Tohru Ikeda , Toshihiko Suzuki 1. Inflammasome Activation Induced by Perfringolysin O of Clostridium perfringens and Its Involvement in the Progression of Gas Gangrene Frontiers in Microbiology. 2019.10;

Anongwee Leewananthaweta,, Shinichi Arakawa, Tokuju Okano, Ryo Daitoku Kinoshita, Hiroshi Ashida, Yuichi Izumi and Toshihiko Suzuki. Ozone ultrafine bubble water induces the cellular signaling involved in oxidative stress responses in human periodontal ligament fibroblasts SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS. 2019.05; 20 (1): 589-598. ( DOI )

Okano T, Ashida H, Suzuki S, Shoji M, Nakayama K, Suzuki T. Porphyromonas gingivalis triggers NLRP3-mediated inflammasome activation in macrophages in a bacterial gingipains-independent manner. European Journal of Imunology. 2018.12; ( DOI )

Yuhei Maruzuru, Takeshi Ichinohe, Ryota Sato, Kensuke Miyake, Tokuju Okano, Toshihiko Suzuki, Takumi Koshiba, Naoto Koyanagi, Shumpei Tsuda, Mizuki Watanabe, Jun Arii, Akihisa Kato, Yasushi Kawaguch. Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication Cell Host & Microbe. 2018.02; 23 (2): 254-265.

岡野 徳壽，鈴木 敏彦. Inhibition of JAK promotes inflammasome activation by oral bacterial infection. 第 98 回日本細菌学会総会 2025.05.31

岡野 徳壽, 鈴木 敏彦. JAK阻害は口腔内細菌感染によるインフラマソーム活性化を促進する(Inhibition of JAK promotes inflammasome activation by oral bacterial infection). 日本細菌学雑誌 2025.04.01

Lin Peiya, Ohsugi Yujin, Okano Tokuju, Imai Chihiro, Toyoshima Keita, Shiba Takahiko, Nagai Shigenori, Suzuki Toshihiko, Katagiri Sayaka. 次世代シークエンサーを用いて調査した歯周炎と関節リウマチの関連性(Investigating the relationship between periodontitis and rheumatoid arthritis using next-generation sequencer). 口腔病学会雑誌 2025.03.01

Tokuju Okano. Hypoxia enhances IL-1β release by inflammasome activation with P. gingivalis infection.. 29th Japan Endotoxin and Innate Immunity Society 2024.11.09 Musashino University

Saki Higano, Tokuju Okano. Clostridioides difficile progresses protein degradation and apoptosis under hypoxia.. 29th Japan Endotoxin and Innate Immunity Society 2024.11.09 Musashino University

Tokuju Okano, Toshihiko Suzuki. A. actinomycetemcomitans exacerbates arthritis via caspase-11 mediated inflammasome activation in macrophages . 第66回歯科基礎医学会学術大会 2024.11.04 Nagasaki

Chenwei Hsu, Tokuju, Okano，Toshihiko Suzuki. Tannerella forsythia induces inflammasome activation by triggering both NLRP3 and Caspase-4. The 97th Annual Meeting of Japanese Society for Bacteriology. 2024.08.07 Sapporo

Hsu Chenwei, 岡野 徳壽, 鈴木 敏彦. Tannerella forsythiaはNLRP3とカスパーゼ-4の両方を引き金としてインフラマソームの活性化を誘導する(Tannerella forsythia induces inflammasome activation by triggering both NLRP3 and Caspase-4). 日本細菌学雑誌 2024.06.01

Chenwei Hsu, 岡野 徳壽, 鈴木 敏彦. Tannerella forsythiaはNLRP3とカスパーゼ4の両者のトリガーとなることでインフラマソーム活性化を誘導する(Tannerella forsythia induces inflammasome activation by triggering both NLRP3 and Caspase-4). 口腔病学会雑誌 2024.03.01

Hsu CHENWEI，岡野徳壽，鈴木敏彦. Tannerella forsythia induces inflammasome activation by triggering both NLRP3 and Caspase- 4. 第88回口腔病学会総会 2023.12.01

岡野　徳壽. Bacterial invasion via integrin alpha M induces activation of caspase-11 mediated noncanonical inflammasome.. 第28回エンドトキシン・自然免疫研究会 2023.12.01

Hsu Chenwei, Okano Tokuju, Suzuki Toshiko. 感染免疫(3)　Tannerella forsythiaはNLRP3とカスパーゼ-4の両方を誘発することによりインフラマソームの活性化を誘導する(Infection immunity　Tannerella forsythia induces inflammasome activation by triggering both NLRP3 and Caspase-4). 日本免疫学会総会・学術集会記録 2023.12.01

Kotchakorn Boonyaleka, Okano Tokuju, Suzuki Toshihiko. 急性結腸炎のマウスにおいてFusobacterium nucleatumの感染は非正規のインフラマソーム経路を活性化して炎症反応を増悪化させる(Fusobacterium nucleatum infection activates the non-canonical inflammasome pathway to exacerbate inflammatory response in acute colitis mice). 口腔病学会雑誌 2023.03.01

Kotchakorn Boonyaleka, Tokuju Okano, Toshihiko Suzuki. Fusobacterium nucleatum infection activates the non-canonical inflammasome pathway to exacerbate inflammatory response in acute colitis mice.. The 51st Annual Meeting of the Japanese Society for Immunology 2022.12.08 Kumamoto-Jo Hall

Tokuju Okano, Toshihiko Suzuki. Porphyromnas gingivalis infection triggers enhancement of severity for EAE following inflammasome activation in macrophages.. The 51st Annual Meeting of the Japanese Society for Immunology 2022.12.07 Kumamoto-Jo Hall

Boonyaleka KOTCHAKORN, Tokuju OKANO, Toshihiko SUZUKI. Fusobacterium nucleatum infection induces non-canonical inflammasome activation to exacerbate inflammation in acute colitis mice.. The 87th Annual Meeting of Stomatological Society, Japan 2022.12.03 Tokyo Medical and Dental University

Okano Tokuju, Suzuki Toshihiko. 感染と免疫I　Porphyromonas gingivalis感染によるマクロファージでのインフラマソーム活性化を契機にEAEの重症化が進む(Infection and Immunity I　Porphyromnas gingivalis infection triggers enhancement of severity for EAE following inflammasome activation in macrophages). 日本免疫学会総会・学術集会記録 2022.11.01

Boonyaleka Kotchakorn, Okano Tokuju, Suzuki Toshihiko. 自然免疫(1)　自然炎症と疾患　Fusobacterium nucleatum感染により非カノニカルなインフラマソーム経路が活性化し急性大腸炎マウスの炎症反応を増悪させる(Innate immunity(1) Innate inflammation and disease　Fusobacterium nucleatum infection activates the non-canonical inflammasome pathway to exacerbate inflammatory response in acute colitis mice). 日本免疫学会総会・学術集会記録 2022.11.01

Okano Tokuju, Suzuki Toshihiko. Aggregatibacter actinomycetemcomitansが産生するインフラマソーム活性化誘導因子は関節炎の原因となる(Inflammasome activation inducer produced by Aggregatibacter actinomycetemcomitans causes arthritis). 口腔病学会雑誌 2021.03.01

岡野 徳壽, 鈴木 敏彦. 低酸素環境と疾患(がん、感染症)の分子論　低酸素環境下においてTRIF-HIF-1α経路はP.gingivalisによるインフラマソーム活性化亢進を制御している(TRIF-HIF-1α signaling under hypoxia drives enhancement of inflammasome activation by P. gingivalis). 日本細菌学雑誌 2021.02.01

岡野 徳壽, 鈴木 敏彦. A.actinomycetemcomitansはリソソーム分解を介してインフラマソーム活性化を誘発する(A. actinomycetemcomitans induces inflammasome activation via lysosomal degradation). 日本細菌学雑誌 2020.01.01

Okano Tokuju, Sasai Miwa, Yamamoto Masahiro, Suzuki Toshihiko. 感染症の免疫学　Aggregatibacter actinomycetemcomitansはリソソーム性分解を介して非標準的インフラマソーム活性化を誘導する(Immunology of infection-2　Aggregatibacter actinomycetemcomitans induces activation of noncanonical inflammasome via lysosomal degradation). 日本免疫学会総会・学術集会記録 2019.11.01

山村 清展, 岡野 徳壽, 大谷 郁, 鈴木 敏彦. ウェルシュ菌によるインフラマゾーム活性化(Inflammasome activation induced by Clostridium perfringens). 日本細菌学雑誌 2019.03.01

岡野 徳壽, 鈴木 志穂, 庄子 幹郎, 中山 浩次, 鈴木 敏彦. 低酸素状態はP.gingivalis感染によるインフラマソーム活性化を増強する(Hypoxia induces enhancement of inflammasome activation by P. gingivalis infection). 日本細菌学雑誌 2019.03.01

Leewananthawet Anongwee, Arakawa Shinichi, Okano Tokuju, Ashida Hiroshi, Izumi Yuichi, Suzuki Toshihiko. in vitroにおけるオゾン微細泡の生物学的影響の評価(Evaluation the biological effects of Ozone Ultrafine-Bubble Water in vitro). 日本歯周病学会会誌 2018.05.01