Personnel Information

写真a

OKANO Tokuju


Job title

Assistant Professor
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Graduate School 【 display / non-display 】

  • Tokyo Medical and Dental University, Doctor's Course, 2020.03, Completed

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Degree 【 display / non-display 】

  • PhD, Tokyo Medical and Dental University

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Campus Career 【 display / non-display 】

  • 2017.04
    -
    2020.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Oral Health Sciences， Bacterial Pathogenesis， Graduate Student
  • 2020.05
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    2021.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Oral Health Sciences， Bacterial Pathogenesis， Project Researcher
  • 2022.03
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Oral Health Sciences， Bacterial Pathogenesis， Assistant Professor
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Qualification Acquired 【 display / non-display 】

  • Veterinarian

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Published Papers & Misc 【 display / non-display 】

  1. Tokuju Okano, Hiroshi Ashida, Noriko Komatsu, Masayuki Tsukasaki, Tamako Iida, Marie Iwasawa, Yuto Takahashi, Yasuo Takeuchi, Takanori Iwata, Miwa Sasai, Masahiro Yamamoto, Hiroshi Takayanagi and Toshihiko Suzuki. Caspase-11 mediated inflammasome activation in macrophages by systemic infection of A. actinomycetemcomitans exacerbates arthritis International Journal of Oral Science. 2024.08; ( DOI )

  2. Suzuki, T; Boonyaleka, K; Okano, T; Iida, T; Yoshida, M; Fukano, H; Hoshino, Y; Iwakura, Y; Ablordey, AS; Ashida, H. Inflammasome-triggered IL-18 controls skin inflammation in the progression of Buruli ulcer PLOS Pathogens. 2023.11; 19 (11): e1011747. ( PubMed, DOI )

  3. Kotchakorn Boonyaleka, Tokuju Okano, Tamako Iida, Anongwee Leewananthawet, Miwa Sasai, Masahiro Yamamoto, Hiroshi Ashida, Toshihiko Suzuki. Fusobacterium nucleatum infection activates the noncanonical inflammasome and exacerbates inflammatory response in DSS-induced colitis European Journal of Immunology. 2023.08; ( DOI )

  4. Sumiko Yoshida Masahiro Hatasa Yujin Ohsugi Yosuke Tsuchiya Anhao Liu Hiromi Niimi Kazuki Morita Tsuyoshi Shimohira Naoki Sasaki Shogo Maekawa Takahiko Shiba Tomomitsu Hirota Tokuju Okano Asuka Hirose Rinko Ibi Kanako Noritake Yuki Tomiga Hiroshi Nitta Toshihiko Suzuki Hirokazu Takahashi Naoyuki Miyasaka Takanori Iwata Sayaka Katagiri. Porphyromonas gingivalis Administration Induces Gestational Obesity, Alters Gene Expression in the Liver and Brown Adipose Tissue in Pregnant Mice, and Causes Underweight in Fetuses Frontiers in Cellular and Infection Microbiology. 2022.01;

  5. Abass A, Okano T, Boonyaleka K, Kinoshita-Daitoku R, Yamaoka S, Ashida H, Suzuki T. Effect of low oxygen concentration on activation of inflammation by Helicobacter pylori Biochemical and Biophysical Research Communications. 2021.05; ( DOI )

  6. Kinoshita-Daitoku R, Kiga K, Sanada T, Ogura Y, Bo Z, Iida T, Yokomori R, Kuroda E, Tanaka M, Sood A, Suzuki T, Nakai K, Hayashi T, Mimuro H. A bacterial small RNA regulates the adaptation of Helicobacter pylori to the host environment Nature Communications. 2021.04; 12 (1): ( DOI )

  7. Mototsugu Tanaka, Ryo Kinoshita-Daitoku, Kotaro Kiga, Takahito Sanada , Bo Zhu, Tokuju Okano, Chihiro Aikawa, Tamako Iida, Yoshitoshi Ogura, Tetsuya Hayashi, Koshu Okubo, Miho Kurosawa, Junichi Hirahashi, Toshihiko Suzuki, Ichiro Nakagawa, Masaomi Nangaku, Hitomi Mimuro . Group A Streptococcus establishes pharynx infection by degrading the deoxyribonucleic acid of neutrophil extracellular traps Scientific Reports. 2020.02; 24 (1): ( DOI )

  8. Kiyonobu Yamamura, Hiroshi Ashida , Tokuju Okano , Ryo Kinoshita-Daitoku, Shiho Suzuki, Kaori Ohtani, Miwako Hamagaki , Tohru Ikeda , Toshihiko Suzuki 1. Inflammasome Activation Induced by Perfringolysin O of Clostridium perfringens and Its Involvement in the Progression of Gas Gangrene Frontiers in Microbiology. 2019.10;

  9. Anongwee Leewananthaweta,, Shinichi Arakawa, Tokuju Okano, Ryo Daitoku Kinoshita, Hiroshi Ashida, Yuichi Izumi and Toshihiko Suzuki. Ozone ultrafine bubble water induces the cellular signaling involved in oxidative stress responses in human periodontal ligament fibroblasts SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS. 2019.05; 20 (1): 589-598. ( DOI )

  10. Okano T, Ashida H, Suzuki S, Shoji M, Nakayama K, Suzuki T. Porphyromonas gingivalis triggers NLRP3-mediated inflammasome activation in macrophages in a bacterial gingipains-independent manner. European Journal of Imunology. 2018.12; ( DOI )

  11. Yuhei Maruzuru, Takeshi Ichinohe, Ryota Sato, Kensuke Miyake, Tokuju Okano, Toshihiko Suzuki, Takumi Koshiba, Naoto Koyanagi, Shumpei Tsuda, Mizuki Watanabe, Jun Arii, Akihisa Kato, Yasushi Kawaguch. Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication Cell Host & Microbe. 2018.02; 23 (2): 254-265.

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Conference Activities & Talks 【 display / non-display 】

  1. Chenwei Hsu，岡野徳壽，鈴木敏彦. Tannerella forsythia induces inflammasome activation by triggering both NLRP3 and Caspase-4. 第97回日本細菌学会総会 2024.08.07

  2. Hsu CHENWEI，岡野徳壽，鈴木敏彦. Tannerella forsythia induces inflammasome activation by triggering both NLRP3 and Caspase- 4. 第88回口腔病学会総会 2023.12.01

  3. 岡野　徳壽. Bacterial invasion via integrin alpha M induces activation of caspase-11 mediated noncanonical inflammasome.. 第28回エンドトキシン・自然免疫研究会 2023.12.01

  4. Kotchakorn Boonyaleka, Tokuju Okano, Toshihiko Suzuki. Fusobacterium nucleatum infection activates the non-canonical inflammasome pathway to exacerbate inflammatory response in acute colitis mice.. The 51st Annual Meeting of the Japanese Society for Immunology 2022.12.08 Kumamoto-Jo Hall

  5. Tokuju Okano, Toshihiko Suzuki. Porphyromnas gingivalis infection triggers enhancement of severity for EAE following inflammasome activation in macrophages.. The 51st Annual Meeting of the Japanese Society for Immunology 2022.12.07 Kumamoto-Jo Hall

  6. Boonyaleka KOTCHAKORN, Tokuju OKANO, Toshihiko SUZUKI. Fusobacterium nucleatum infection induces non-canonical inflammasome activation to exacerbate inflammation in acute colitis mice.. The 87th Annual Meeting of Stomatological Society, Japan 2022.12.03 Tokyo Medical and Dental University

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Others 【 display / non-display 】

  • Shedding Light on How Oral Bacteria Can Aggravate Rheumatoid Arthritis ，2024.09

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