Personnel Information

写真a

ITAKA Keiji


Job title

Professor

Laboratory Address

2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo

Laboratory Phone number

81-35280-8088

Laboratory Fax number

81-35280-8088

Mail Address

itaka.bif@tmd.ac.jp

Homepage URL

http://www.tmd.ac.jp/i-mde/www/biofunctions/biofunctions-e.html

Research Areas, Keywords

DDS, Gene therapy, Regenerative medicine
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Graduating School 【 display / non-display 】

  • The University of Tokyo, Faculty of Medicine, 1991.03, Graduated

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Graduate School 【 display / non-display 】

  • The University of Tokyo, Graduate School, Division of Medical Sciences, Doctor's Course, 2003.03, Completed

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Degree 【 display / non-display 】

  • Ph.D. (Medicine), The University of Tokyo

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Campus Career 【 display / non-display 】

  • 2017.04
    -
    2023.03
    Tokyo Medical and Dental University， Institute of Biomaterials and Bioengineering， Biofunctional Restoration， Material Biofunctions， Professor
  • 2023.04
    -
    Now
    Tokyo Medical and Dental University， Institute of Biomaterials and Bioengineering， -， -， Professor
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External Career 【 display / non-display 】

  • 1991.06
    -
    1991.12
    The University of Tokyo Hospital, Dpt Orthopedic Surgery, Trainee Resident
  • 1992.01
    -
    1992.06
    , Trainee Resident
  • 1997.01
    -
    1997.12
    The University of Tokyo Hospital, Orthpaedic Surgery,
  • 1998.01
    -
    1998.12
    The University of Tokyo Hospital Branch Hospital, Orthpaedic Surgery, Senior Resident
  • 2003.04
    -
    2004.08
    The University of Tokyo, Graduate School of Engineering, Project Researcher
  • 2004.09
    -
    2008.11
    The University of Tokyo, Graduate School of Medicine, Project Junior Associate Professor
  • 2006.06
    -
    2007.12
    Harvard Medical School, Massachusetts General Hospital, Visiting Researcher
  • 2008.12
    -
    2017.03
    The University of Tokyo, Graduate School of Medicine, Project Associate Professor

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Academic Activity 【 display / non-display 】

  • 2017
    -
    Now
    The Journal of Gene Medicine Editorial Board
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Research Areas 【 display / non-display 】

  • Drug Delivery System

  • Orthopedics

  • Nanobioscience

  • Biomedical engineering

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Qualification Acquired 【 display / non-display 】

  • Doctor

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Published Papers & Misc 【 display / non-display 】

  1. Deng J, Fukushima Y, Nozaki K, Nakanishi H, Yada E, Terai Y, Fueki K, Itaka K. Anti-Inflammatory Therapy for Temporomandibular Joint Osteoarthritis Using mRNA Medicine Encoding Interleukin-1 Receptor Antagonist Pharmaceutics. 2022.08; 14 (9): 1785.

  2. Hashimoto Yasumasa, Kuniishi Hiroshi, Sakai Kazuhisa, Fukushima Yuta, Du Xuan, Yamashiro Kunihiko, Hori Kei, Motohashi Norio, Imamura Michihiro, Hoshino Mikio, Yamada Mitsuhiko, Araki Toshiyuki, Sakagami Hiroyuki, Takeda Shin'ichi, Itaka Keiji, Ichinohe Noritaka, Muntoni Francesco, Sekiguchi Masayuki, Aoki Yoshitsugu. Brain Dp140 alters glutamatergic transmission and social behaviour in Duchenne muscular dystrophy mouse model NEUROMUSCULAR DISORDERS. 2021.10; 31

  3. Fukushima Yuta, Uchida Satoshi, Imai Hideaki, Nakatomi Hirofumi, Kataoka Kazunori, Saito Nobuhito, Itaka Keiji. Treatment of ischemic neuronal death by introducing brain-derived neurotrophic factor mRNA using polyplex nanomicelle BIOMATERIALS. 2021.03; 270 120681. ( PubMed, DOI )

  4. Li Jinyu, Sasaki Naoko, Itaka Keiji, Terpstra Margo, Levato Riccardo, Matsusaki Michiya. Regulation of Chondrocyte Differentiation by Changing Intercellular Distances Using Type II Collagen Microfibers ACS BIOMATERIALS SCIENCE & ENGINEERING. 2020.10; 6 (10): 5711-5719. ( PubMed, DOI )

  5. Uchida S, Yanagihara K, Matsui A, Kataoka K, Itaka K. mRNA as a Tool for Gene Transfection in 3D Cell Culture for Future Regenerative Therapy. Micromachines. 2020.04; 11 (4): ( PubMed, DOI )

  6. Hayashi Kenichiro, Nozaki Kosuke, Tan Zhenquan, Fujita Kazuhisa, Nemoto Reina, Yamashita Kimihiro, Miura Hiroyuki, Itaka Keiji, Ohara Satoshi. Enhanced Antibacterial Property of Facet-Engineered TiO2 Nanosheet in Presence and Absence of Ultraviolet Irradiation MATERIALS. 2020.01; 13 (1): ( PubMed, DOI )

  7. Crowley Samuel T., Fukushima Yuta, Uchida Satoshi, Kataoka Kazunori, Itaka Keiji. Enhancement of Motor Function Recovery after Spinal Cord Injury in Mice by Delivery of Brain-Derived Neurotrophic Factor mRNA MOLECULAR THERAPY-NUCLEIC ACIDS. 2019.09; 17 465-476. ( PubMed, DOI )

  8. Matsumoto Masahito, Itaka Keiji. Pax6の骨およびグルコース代謝の調節における細胞分化を介した二重機能の役割(Dual functional roles of Pax6 in the regulation of bone and glucose metabolism via cell differentiation) 組織培養研究. 2019.06; 38 (2): 59. ( ichushi )

  9. Lin CY, Crowley ST, Uchida S, Komaki Y, Kataoka K, Itaka K. Treatment of Intervertebral Disk Disease by the Administration of mRNA Encoding a Cartilage-Anabolic Transcription Factor. Molecular therapy. Nucleic acids. 2019.02; 16 162-171. ( PubMed, DOI )

  10. Akitsugu Matsui, Satoshi Uchida, Akimasa Hayashi, Kazunori Kataoka, Keiji Itaka. Prolonged engraftment of transplanted hepatocytes in the liver by transient pro-survival factor supplementation using ex vivo mRNA transfection. J Control Release. 2018.09; 285 1-11. ( PubMed, DOI )

  11. Kayoko Yanagihara, Satoshi Uchida, Shinsuke Ohba, Kazunori Kataoka, Keiji Itaka. Treatment of Bone Defects by Transplantation of Genetically Modified Mesenchymal Stem Cell Spheroids. Mol Ther Methods Clin Dev. 2018.06; 9 358-366. ( PubMed, DOI )

  12. Samuel T Crowley, Kazunori Kataoka, Keiji Itaka. Combined CatWalk Index: an improved method to measure mouse motor function using the automated gait analysis system. BMC Res Notes. 2018.04; 11 (1): 263. ( PubMed, DOI )

  13. Y Anraku, H Kuwahara, Y Fukusato, A Mizoguchi, T Ishii, K Nitta, Y Matsumoto, K Toh, K Miyata, S Uchida, K Nishina, K Osada, K Itaka, N Nishiyama, H Mizusawa, T Yamasoba, T Yokota, K Kataoka. Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain. Nat Commun. 2017.10; 8 (1): 1001. ( PubMed, DOI )

  14. Satoshi Uchida, Naoto Yoshinaga, Kayoko Yanagihara, Eiji Yuba, Kazunori Kataoka, Keiji Itaka. Designing immunostimulatory double stranded messenger RNA with maintained translational activity through hybridization with poly A sequences for effective vaccination. Biomaterials. 2017.09; ( PubMed, DOI )

  15. Federico Perche, Satoshi Uchida, Hiroki Akiba, Chin-Yu Lin, Masaru Ikegami, Anjaneyulu Dirisala, Toshihiro Nakashima, Keiji Itaka, Kohei Tsumoto, Kazunori Kataoka. Improved Brain Expression of Anti-Amyloid β scFv by Complexation of mRNA Including a Secretion Sequence with PEG-based Block Catiomer. Curr Alzheimer Res. 2017.03; 14 (3): 295-302. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. MAORUI‌ZHANG，福島雄大，野崎浩佑，中西秀之，若林則幸，位高啓史. Enhancement of bone regeneration by coadministration of angiogenic and osteogenic factors using messenger RNA. 第44回日本炎症・再生医学会 2023.07.12

  2. Maorui Zhang, Yuta Fukushima, Kosuke Nozaki, Noriyuki Wakabayashi, Keiji Itaka. Co-delivery of Runx2 and VEGF Messenger RNA by Polyplex Nanomicelles Improves the Process of Mandibular Bone Regeneration. 第22回日本再生医療学会総会 2023.03.24

  3. Kosuke Nozaki, Kenichiro Hayashi, Zhenquan Tan, Kimihiro Yamashita, Hiroyuki Miura, Satoshi Ohara, and Keiji Itaka. Antibacterial effect of highly oriented TiO2 nanosheet in dark conditions. The 4th International Symposium on Biomedical Engineering (ISBE2019) 2019.11.14

  4. Keiji Itaka. mRNA medicine as a new paradigm of gene therapy for intractable diseases and regenerative medicine. 6th International mRNA Health Conference 2018.11.13 Boston, USA

  5. Keiji Itaka. mRNA-based therapy for intractable diseases and regenerative medicine. 3rd International Symposium on Biomedical Engineering 2018.11.08 広島大学、広島

  6. Kenichiro Hayashi, Kosuke Nozaki, Zhenquan Tan, Naohiro Horiuchi, Kimihiro Yamashita, Hiroyuki Miura, Keiji Itaka and Satoshi Ohara4. Antibacterial property of titania nanosheet synthesized by organic ligand-assisted hydrothermal reaction. The 3rd International Symposium on Creation of Life Innovation Materials for Interdisciplinary and International Researcher Development (iLIM-3) 2018.09.25

  7. Keiji Itaka, Shinsuke Ohba, Satoshi Uchida, Ung-il Chung, Kazunori Kataoka. mRNA-based therapy for cartilage degeneration diseases. 5th TERMIS World Congress – 2018 Kyoto, Japan 2018.09.04

  8. Keiji Itaka. mRNA-based therapy for intractable diseases and regenerative medicine. The 6th Japan-China Symposium on Nanomedicine 2018.05.26

  9. Samuel Crowley, Kazunori Kataoka, Keiji Itaka. Enhancement of motor function recovery in mice by delivery of mRNA nanomicelles encoding brain derived neurotrophic factor.. 3rd Japan-US Technical Information Exchange Forum on Blast Injury (JUFBI 2018) 2018.05.09

  10. Keiji Itaka. mRNA-based therapy for intractable diseases and regenerative medicine. 5th International mRNA Health Conference 2017.11.12 Berlin, Germany

  11. K. Nozaki, K. Fujita, N. Horiuchi, K. Yamashita, H. Miura, A. Nagai, K. Itaka. Regulation of periodontal ligament-derived cell morphology by type III collagen-coated hydroxyapatite. 2nd International Symposium on Creation of Life Innovation Materials 2017.09.30

  12. Kosuke Nozaki, Takayuki Endo, Naohiro Horiuchi, Kimihiro Yamashita, Kazuaki Hashimoto, Keiji Itaka, Akiko Nagai. Electrical and structural evaluation of sodium ion doped beta-tricalcium phosphate. The Tenth International Conference on the Science and Technology for Advanced Ceramics (STAC-10) 2017.08.02

  13. Samuel T. Crowley, Satoshi Uchida, Kazunori Kataoka, Keiji Itaka. Nonviral Delivery of BDNF mRNA Polyplex Improves Recovery After Spinal Cord Injury in Mice. ASGCT 20th Annual Meeting 2017.05.12 Washington, DC, USA

  14. Keiji Itaka. mRNA-based therapeutics for intractable diseases and regenerative medicine. TIDES: Oligonucleotide&Peptide Therapeutics 2017.05.01

  15. 福島雄大、内田智士、今井英明、片岡一則、斉藤延人、位髙啓史. mRNA-based therapy for cerebral ischemia -Enhanced neuroprotective effects of astrocytes by BDNF mRNA. 第２回日米爆傷フォーラム（Japan-US Technical Information Exchange Forum on Blast Injury JUFBI 2017） 2017.04.16

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Awards & Honors 【 display / non-display 】

  • Best Abstract Award，4rd International mRNA Health Conference，2016.11

  • The Mizushima Award，The Japan Society of Drug Delivery System，2016.07

  • Best presentation award，The Japanese Society of Inflammation and Regeneration ，2016.06

  • Best poster award，3rd International mRNA Health Conference，2015.11

  • The Award for Young Investigator of Japanese Society for Biomaterials，Japanese Society for Biomaterials，2011.11

  • CRS-Capsugel graduate/posdoc award，28th International Symposium on Controlled Release of Bioactive Materials，2001.06

  • The Nagai Foundation Tokyo CRS Graduate Student/Posdoc Award，28th International Symposium on Controlled Release of Bioactive Materials，2001.06

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Others 【 display / non-display 】

  • A novel bone regeneration technique with clinical potential，2023.07

  • A new agent for the brain diseases: mRNA，2021.04

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Social Contribution 【 display / non-display 】

  • mRNA: Medical Messenger of Hope，2021.01.28

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