基本情報

写真a

芦田 浩(アシダ ヒロシ)

ASHIDA Hiroshi


職名

准教授

出身学校 【 表示 / 非表示

  • 東京工業大学  生命理工学部  2002年03月  卒業

出身大学院 【 表示 / 非表示

  • 東京工業大学  生命理工学研究科  修士課程  2004年03月  修了

  • 東京大学  医学系研究科  博士課程  2008年03月  修了

取得学位 【 表示 / 非表示

  • 博士(医学)  

経歴(学内) 【 表示 / 非表示

  • 2017年04月
    -
    2018年03月
    東京医科歯科大学 大学院医歯学総合研究科 医歯学系専攻 口腔機能再構築学講座 細菌感染制御学 准教授
  • 2018年04月
    -
    2020年05月
    東京医科歯科大学 大学院医歯学総合研究科 医歯学系専攻 口腔機能再構築学講座 細菌感染制御学 准教授
  • 2020年06月
    -
    現在
    東京医科歯科大学 大学院医歯学総合研究科 医歯学系専攻 口腔機能再構築学講座 細菌感染制御学 准教授

経歴(学外) 【 表示 / 非表示

  • 2017年04月
    -
    現在
    千葉大学 真菌医学研究センター 客員准教授

所属学協会 【 表示 / 非表示

  • 日本細菌学会

  • 日本免疫学会

  • 口腔病学会

研究分野 【 表示 / 非表示

  • 細菌学

 

競争的資金等の研究課題 【 表示 / 非表示

  • 腸管病原細菌感染現象の横断的解析

    文部科学省/日本学術振興会 : 2016年 - 2018年

  • 腸管病原細菌による宿主生体防御クロストーク抑制機構の解明

    文部科学省/日本学術振興会

  • 腸管病原細菌による宿主生体防御クロストーク抑制機構の解明

    文部科学省/日本学術振興会

論文・総説 【 表示 / 非表示

  1. Abass A, Okano T, Boonyaleka K, Kinoshita-Daitoku R, Yamaoka S, Ashida H, Suzuki T. Effect of low oxygen concentration on activation of inflammation by Helicobacter pylori Biochem Biophys Res Commun. 2021.06; 560 179-185. ( DOI )

  2. Kinoshita-Daitoku R, Kiga K, Miyakoshi M, Otsubo R, Ogura Y, Sanada T, Bo Z, Phuoc TV, Okano T, Iida T, Yokomori R, Kuroda E, Hirukawa S, Tanaka M, Sood A, Subsomwong P, Ashida H, Binh TT, Nguyen LT, Van KV, Ho DQD, Nakai K, Suzuki T, Yamaoka Y, Hayashi T, Mimuro H. A bacterial small RNA regulates the adaptation of Helicobacter pylori to the host environment Nat Commun. 2021.04; 12 (1): 2085. ( DOI )

  3. Ashida H, Suzuki T, Sasakawa C. Shigella infection and host cell death: A double-edged sword for the host and pathogen survival Current Opinion in Microbiology. 2021.02; 59 1-7. ( DOI )

  4. Kurashima Y, Kigoshi T, Murasaki S, Arai F, Shimada K, Seki N, Kim YG, Hase K, Ohno H, Kawano K, Ashida H, Suzuki T, Morimoto M, Saito Y, Sasou A, Goda Y, Yuki Y, Inagaki Y, Iijima H, Suda W, Hattori M, Kiyono H. Pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation Nat Commun. 2021.02; 12 (1): 1067. ( DOI )

  5. Ashida H, Sasakawa C, Suzuki T. A unique bacterial tactic to circumvent the cell death crosstalk induced by blockade of caspase-8 EMBO J. 2020.08; e104469. ( DOI )

  6. Yamamura K, Ashida H, Okano T, Kinoshita-Daitoku R, Suzuki S, Ohtani K, Hamagaki M, Ikeda T, Suzuki T. Inflammasome Activation Induced by Perfringolysin O of Clostridium perfringens and Its Involvement in the Progression of Gas Gangrene Front Microbiol. 2019.10; 10 2406. ( DOI )

  7. Ryota Otsubo, Hitomi Mimuro, Hiroshi Ashida, Jun Hamazaki, Shigeo Murata, Chihiro Sasakawa. Shigella effector IpaH4.5 targets 19S regulatory particle subunit RPN13 in the 26S proteasome to dampen cytotoxic T lymphocyte activation. Cell. Microbiol.. 2019.03; 21 (3): e12974. ( PubMed, DOI )

  8. Anongwee Leewananthawet, Shinichi Arakawa, Tokuju Okano, Ryo Daitoku Kinoshita, Hiroshi Ashida, Yuichi Izumi, Toshihiko Suzuki. Ozone ultrafine bubble water induces the cellular signaling involved in oxidative stress responses in human periodontal ligament fibroblasts. Sci Technol Adv Mater. 2019; 20 (1): 589-598. ( PubMed, DOI )

  9. Nobuhiro Nakamoto, Nobuo Sasaki, Ryo Aoki, Kentaro Miyamoto, Wataru Suda, Toshiaki Teratani, Takahiro Suzuki, Yuzo Koda, Po-Sung Chu, Nobuhito Taniki, Akihiro Yamaguchi, Mitsuhiro Kanamori, Nobuhiko Kamada, Masahira Hattori, Hiroshi Ashida, Michiie Sakamoto, Koji Atarashi, Seiko Narushima, Akihiko Yoshimura, Kenya Honda, Toshiro Sato, Takanori Kanai. Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis. Nat Microbiol. 2019; 4 (3): 492-503. ( PubMed, DOI )

  10. Tokuju Okano, Hiroshi Ashida, Shiho Suzuki, Mikio Shoji, Koji Nakayama, Toshihiko Suzuki. Porphyromonas gingivalis triggers NLRP3-mediated inflammasome activation in macrophages in a bacterial gingipains-independent manner. Eur. J. Immunol.. 2018; 48 (12): 1965-1974. ( PubMed, DOI )

  11. Hiroshi Ashida, Chihiro Sasakawa. Bacterial E3 ligase effectors exploit host ubiquitin systems. Curr. Opin. Microbiol.. 2017; 35 16-22. ( PubMed, DOI )

  12. Hiroshi Ashida, Chihiro Sasakawa. Shigella IpaH Family Effectors as a Versatile Model for Studying Pathogenic Bacteria. Front Cell Infect Microbiol. 2015; 5 100. ( PubMed, DOI )

  13. Hiroshi Ashida, Hitomi Mimuro, Chihiro Sasakawa. Shigella manipulates host immune responses by delivering effector proteins with specific roles. Front Immunol. 2015; 6 219. ( PubMed, DOI )

  14. Hiroshi Ashida, Minsoo Kim, Chihiro Sasakawa. Manipulation of the host cell death pathway by Shigella. Cell. Microbiol.. 2014.12; 16 (12): 1757-1766. ( PubMed, DOI )

  15. Hiroshi Ashida, Chihiro Sasakawa. Shigella hacks host immune responses by reprogramming the host epigenome. EMBO J.. 2014.11; 33 (22): 2598-2600. ( PubMed, DOI )

  16. Shiho Suzuki, Hitomi Mimuro, Minsoo Kim, Michinaga Ogawa, Hiroshi Ashida, Takahito Toyotome, Luigi Franchi, Masato Suzuki, Takahito Sanada, Toshihiko Suzuki, Hiroko Tsutsui, Gabriel Núñez, Chihiro Sasakawa. Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages. Proc. Natl. Acad. Sci. U.S.A.. 2014.10; 111 (40): E4254-E4263. ( PubMed, DOI )

  17. Hiroshi Ashida, Minsoo Kim, Chihiro Sasakawa. Exploitation of the host ubiquitin system by human bacterial pathogens. Nat. Rev. Microbiol.. 2014.06; 12 (6): 399-413. ( PubMed, DOI )

  18. Taira Kobayashi, Michinaga Ogawa, Takahito Sanada, Hitomi Mimuro, Minsoo Kim, Hiroshi Ashida, Reiko Akakura, Mitsutaka Yoshida, Magdalena Kawalec, Jean-Marc Reichhart, Tsunehiro Mizushima, Chihiro Sasakawa. The Shigella OspC3 effector inhibits caspase-4, antagonizes inflammatory cell death, and promotes epithelial infection. Cell Host Microbe. 2013.05; 13 (5): 570-583. ( PubMed, DOI )

  19. Hiroshi Ashida, Hiroyasu Nakano, Chihiro Sasakawa. Shigella IpaH0722 E3 ubiquitin ligase effector targets TRAF2 to inhibit PKC-NF-κB activity in invaded epithelial cells. PLoS Pathog.. 2013; 9 (6): e1003409. ( PubMed, DOI )

  20. Takahito Sanada, Minsoo Kim, Hitomi Mimuro, Hiroshi Ashida, Michinaga Ogawa, Tsunehiro Mizushima, Chihiro Sasakawa. A bacterial effector targets the TRAF6-NFκB pathway to modulate the acute inflammatory response to bacterial invasion of epithelial cells. Virulence. 2012.10; 3 (6): 518-521. ( PubMed, DOI )

  21. Takahito Sanada, Minsoo Kim, Hitomi Mimuro, Masato Suzuki, Michinaga Ogawa, Akiho Oyama, Hiroshi Ashida, Taira Kobayashi, Tomohiro Koyama, Shinya Nagai, Yuri Shibata, Jin Gohda, Jun-ichiro Inoue, Tsunehiro Mizushima, Chihiro Sasakawa. The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response. Nature. 2012.03; 483 (7391): 623-626. ( PubMed, DOI )

  22. Hiroshi Ashida, Michinaga Ogawa, Minsoo Kim, Hitomi Mimuro, Chihiro Sasakawa. Bacteria and host interactions in the gut epithelial barrier. Nat. Chem. Biol.. 2011.12; 8 (1): 36-45. ( PubMed, DOI )

  23. Hiroshi Ashida, Hitomi Mimuro, Michinaga Ogawa, Taira Kobayashi, Takahito Sanada, Minsoo Kim, Chihiro Sasakawa. Cell death and infection: a double-edged sword for host and pathogen survival. J. Cell Biol.. 2011.12; 195 (6): 931-942. ( PubMed, DOI )

  24. Hiroshi Ashida, Michinaga Ogawa, Hitomi Mimuro, Taira Kobayashi, Takahito Sanada, Chihiro Sasakawa. Shigella are versatile mucosal pathogens that circumvent the host innate immune system. Curr. Opin. Immunol.. 2011.08; 23 (4): 448-455. ( PubMed, DOI )

  25. Michinaga Ogawa, Hitomi Mimuro, Yuko Yoshikawa, Hiroshi Ashida, Chihiro Sasakawa. Manipulation of autophagy by bacteria for their own benefit. Microbiol. Immunol.. 2011.07; 55 (7): 459-471. ( PubMed, DOI )

  26. Nozomi Ishijima, Masato Suzuki, Hiroshi Ashida, Yusuke Ichikawa, Yumi Kanegae, Izumu Saito, Thomas Borén, Rainer Haas, Chihiro Sasakawa, Hitomi Mimuro. BabA-mediated adherence is a potentiator of the Helicobacter pylori type IV secretion system activity. J. Biol. Chem.. 2011.07; 286 (28): 25256-25264. ( PubMed, DOI )

  27. Michinaga Ogawa, Yuko Yoshikawa, Taira Kobayashi, Hitomi Mimuro, Makoto Fukumatsu, Kotaro Kiga, Zhenzi Piao, Hiroshi Ashida, Mitsutaka Yoshida, Shigeru Kakuta, Tomohiro Koyama, Yoshiyuki Goto, Takahiro Nagatake, Shinya Nagai, Hiroshi Kiyono, Magdalena Kawalec, Jean-Marc Reichhart, Chihiro Sasakawa. A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens. Cell Host Microbe. 2011.05; 9 (5): 376-389. ( PubMed, DOI )

  28. Hiroshi Ashida, Michinaga Ogawa, Minsoo Kim, Shiho Suzuki, Takahito Sanada, Claire Punginelli, Hitomi Mimuro, Chihiro Sasakawa. Shigella deploy multiple countermeasures against host innate immune responses. Curr. Opin. Microbiol.. 2011.02; 14 (1): 16-23. ( PubMed, DOI )

  29. Minsoo Kim, Hiroshi Ashida, Michinaga Ogawa, Yuko Yoshikawa, Hitomi Mimuro, Chihiro Sasakawa. Bacterial interactions with the host epithelium. Cell Host Microbe. 2010.07; 8 (1): 20-35. ( PubMed, DOI )

  30. Hiroshi Ashida, Minsoo Kim, Marc Schmidt-Supprian, Averil Ma, Michinaga Ogawa, Chihiro Sasakawa. A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKgamma to dampen the host NF-kappaB-mediated inflammatory response. Nat. Cell Biol.. 2010.01; 12 (1): 66-73; sup pp 1. ( PubMed, DOI )

  31. Hiroshi Ashida, Michinaga Ogawa, Hitomi Mimuro, Chihiro Sasakawa. Shigella infection of intestinal epithelium and circumvention of the host innate defense system. Curr. Top. Microbiol. Immunol.. 2009; 337 231-255. ( PubMed, DOI )

  32. Michinaga Ogawa, Yutaka Handa, Hiroshi Ashida, Masato Suzuki, Chihiro Sasakawa. The versatility of Shigella effectors. Nat. Rev. Microbiol.. 2008.01; 6 (1): 11-16. ( PubMed, DOI )

  33. Hiroki Iwai, Minsoo Kim, Yuko Yoshikawa, Hiroshi Ashida, Michinaga Ogawa, Yukihiro Fujita, Daniel Muller, Teruo Kirikae, Peter K Jackson, Shuji Kotani, Chihiro Sasakawa. A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling. Cell. 2007.08; 130 (4): 611-623. ( PubMed, DOI )

  34. Toshihiko Suzuki, Luigi Franchi, Claudia Toma, Hiroshi Ashida, Michinaga Ogawa, Yuko Yoshikawa, Hitomi Mimuro, Naohiro Inohara, Chihiro Sasakawa, Gabriel Nuñez. Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages. PLoS Pathog.. 2007.08; 3 (8): e111. ( PubMed, DOI )

  35. Hiroshi Ashida, Takahito Toyotome, Takeshi Nagai, Chihiro Sasakawa. Shigella chromosomal IpaH proteins are secreted via the type III secretion system and act as effectors. Mol. Microbiol.. 2007.02; 63 (3): 680-693. ( PubMed, DOI )

  36. Toshihiko Suzuki, Yuko Yoshikawa, Hiroshi Ashida, Hiroki Iwai, Takahito Toyotome, Hidenori Matsui, Chihiro Sasakawa. High vaccine efficacy against shigellosis of recombinant noninvasive Shigella mutant that expresses Yersinia invasin. J. Immunol.. 2006.10; 177 (7): 4709-4717. ( PubMed, DOI )

▼全件表示

その他業績 【 表示 / 非表示

  • 2020年08月

    AAAS EurekAlert! The Global Souce for Science News

  • 「腸管病原菌による宿主細胞死クロストーク抑制機構の解明」―赤痢菌の新たな感染戦略を解明―,2020年07月

    EMBO Journal