Personnel Information

写真a

ASHIDA Hiroshi


Job title

Associate Professor
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Graduating School 【 display / non-display 】

  • Tokyo Institute of Technology, 2002.03, Graduated

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Graduate School 【 display / non-display 】

  • Tokyo Institute of Technology, Master's Course, 2004.03, Completed

  • The University of Tokyo, Graduate School, Division of Medical Sciences, Doctor's Course, 2008.03, Completed

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Campus Career 【 display / non-display 】

  • 2017.04
    -
    2018.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Oral Health Sciences， Bacterial Pathogenesis， Associate Professor
  • 2018.04
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    2020.05
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Oral Health Sciences， Bacterial Pathogenesis， Associate Professor
  • 2020.06
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    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Oral Health Sciences， Bacterial Pathogenesis， Associate Professor
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Research Areas 【 display / non-display 】

  • Bacteriology

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Published Papers & Misc 【 display / non-display 】

  1. Suzuki, T; Boonyaleka, K; Okano, T; Iida, T; Yoshida, M; Fukano, H; Hoshino, Y; Iwakura, Y; Ablordey, AS; Ashida, H. Inflammasome-triggered IL-18 controls skin inflammation in the progression of Buruli ulcer PLOS Pathogens. 2023.11; 19 (11): e1011747. ( PubMed, DOI )

  2. Umeda S, Sujino T, Miyamoto K, Yoshimatsu Y, Harada Y, Nishiyama K, Aoto Y, Adachi K, Hayashi N, Amafuji K, Moritoki N, Shibata S, Sasaki N, Mita M, Tanemoto S, Ono K, Mikami Y, Sasabe J, Takabayashi K, Hosoe N, Suzuki T, Sato T, Atarashi K, Teratani T, Ogata H, Nakamoto N, Shiomi D, Ashida H, Kanai T. D-amino Acids Ameliorate Experimental Colitis and Cholangitis by Inhibiting Growth of Proteobacteria: Potential Therapeutic Role in Inflammatory Bowel Disease. Cellular and molecular gastroenterology and hepatology. 2023.08; 16 1011-1031. ( PubMed, DOI )

  3. Miyamoto K, Sujino T, Harada Y, Ashida H, Yoshimatsu Y, Yonemoto Y, Nemoto Y, Tomura M, Melhem H, Niess JH, Suzuki T, Suzuki T, Suzuki S, Koda Y, Okamoto R, Mikami Y, Teratani T, Tanaka K, Yoshimura A, Sato T, Kanai T. The gut microbiota-induced kynurenic acid recruits GPR35-positive macrophages to promote experimental encephalitis. Cell reports. 2023.08; 42 (8): 113005. ( PubMed, DOI )

  4. Boonyaleka K, Okano T, Iida T, Leewananthawer A, Sasai M, Yamamoto M, Ashida H, Suzuki T. Fusobacterium nucleatum infection activates the noncanonical inflammasome to exacerbate inflammatory response in acute colitis mice Eur. J. Immunol. 2023.07; e2350455

  5. Abass A, Okano T, Boonyaleka K, Kinoshita-Daitoku R, Yamaoka S, Ashida H, Suzuki T. Effect of low oxygen concentration on activation of inflammation by Helicobacter pylori Biochem Biophys Res Commun. 2021.06; 560 179-185. ( DOI )

  6. Kinoshita-Daitoku R, Kiga K, Miyakoshi M, Otsubo R, Ogura Y, Sanada T, Bo Z, Phuoc TV, Okano T, Iida T, Yokomori R, Kuroda E, Hirukawa S, Tanaka M, Sood A, Subsomwong P, Ashida H, Binh TT, Nguyen LT, Van KV, Ho DQD, Nakai K, Suzuki T, Yamaoka Y, Hayashi T, Mimuro H. A bacterial small RNA regulates the adaptation of Helicobacter pylori to the host environment Nat Commun. 2021.04; 12 (1): 2085. ( DOI )

  7. Ashida H, Suzuki T, Sasakawa C. Shigella infection and host cell death: A double-edged sword for the host and pathogen survival Current Opinion in Microbiology. 2021.02; 59 1-7. ( DOI )

  8. Kurashima Y, Kigoshi T, Murasaki S, Arai F, Shimada K, Seki N, Kim YG, Hase K, Ohno H, Kawano K, Ashida H, Suzuki T, Morimoto M, Saito Y, Sasou A, Goda Y, Yuki Y, Inagaki Y, Iijima H, Suda W, Hattori M, Kiyono H. Pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation Nat Commun. 2021.02; 12 (1): 1067. ( DOI )

  9. Ashida H, Sasakawa C, Suzuki T. A unique bacterial tactic to circumvent the cell death crosstalk induced by blockade of caspase-8 EMBO J. 2020.08; e104469. ( DOI )

  10. Yamamura K, Ashida H, Okano T, Kinoshita-Daitoku R, Suzuki S, Ohtani K, Hamagaki M, Ikeda T, Suzuki T. Inflammasome Activation Induced by Perfringolysin O of Clostridium perfringens and Its Involvement in the Progression of Gas Gangrene Front Microbiol. 2019.10; 10 2406. ( DOI )

  11. Ryota Otsubo, Hitomi Mimuro, Hiroshi Ashida, Jun Hamazaki, Shigeo Murata, Chihiro Sasakawa. Shigella effector IpaH4.5 targets 19S regulatory particle subunit RPN13 in the 26S proteasome to dampen cytotoxic T lymphocyte activation. Cell. Microbiol.. 2019.03; 21 (3): e12974. ( PubMed, DOI )

  12. Nobuhiro Nakamoto, Nobuo Sasaki, Ryo Aoki, Kentaro Miyamoto, Wataru Suda, Toshiaki Teratani, Takahiro Suzuki, Yuzo Koda, Po-Sung Chu, Nobuhito Taniki, Akihiro Yamaguchi, Mitsuhiro Kanamori, Nobuhiko Kamada, Masahira Hattori, Hiroshi Ashida, Michiie Sakamoto, Koji Atarashi, Seiko Narushima, Akihiko Yoshimura, Kenya Honda, Toshiro Sato, Takanori Kanai. Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis. Nat Microbiol. 2019; 4 (3): 492-503. ( PubMed, DOI )

  13. Anongwee Leewananthawet, Shinichi Arakawa, Tokuju Okano, Ryo Daitoku Kinoshita, Hiroshi Ashida, Yuichi Izumi, Toshihiko Suzuki. Ozone ultrafine bubble water induces the cellular signaling involved in oxidative stress responses in human periodontal ligament fibroblasts. Sci Technol Adv Mater. 2019; 20 (1): 589-598. ( PubMed, DOI )

  14. Tokuju Okano, Hiroshi Ashida, Shiho Suzuki, Mikio Shoji, Koji Nakayama, Toshihiko Suzuki. Porphyromonas gingivalis triggers NLRP3-mediated inflammasome activation in macrophages in a bacterial gingipains-independent manner. Eur. J. Immunol.. 2018; 48 (12): 1965-1974. ( PubMed, DOI )

  15. Hiroshi Ashida, Chihiro Sasakawa. Bacterial E3 ligase effectors exploit host ubiquitin systems. Curr. Opin. Microbiol.. 2017; 35 16-22. ( PubMed, DOI )

  16. Hiroshi Ashida, Chihiro Sasakawa. Shigella IpaH Family Effectors as a Versatile Model for Studying Pathogenic Bacteria. Front Cell Infect Microbiol. 2015; 5 100. ( PubMed, DOI )

  17. Hiroshi Ashida, Hitomi Mimuro, Chihiro Sasakawa. Shigella manipulates host immune responses by delivering effector proteins with specific roles. Front Immunol. 2015; 6 219. ( PubMed, DOI )

  18. Hiroshi Ashida, Minsoo Kim, Chihiro Sasakawa. Manipulation of the host cell death pathway by Shigella. Cell. Microbiol.. 2014.12; 16 (12): 1757-1766. ( PubMed, DOI )

  19. Hiroshi Ashida, Chihiro Sasakawa. Shigella hacks host immune responses by reprogramming the host epigenome. EMBO J.. 2014.11; 33 (22): 2598-2600. ( PubMed, DOI )

  20. Shiho Suzuki, Hitomi Mimuro, Minsoo Kim, Michinaga Ogawa, Hiroshi Ashida, Takahito Toyotome, Luigi Franchi, Masato Suzuki, Takahito Sanada, Toshihiko Suzuki, Hiroko Tsutsui, Gabriel Núñez, Chihiro Sasakawa. Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages. Proc. Natl. Acad. Sci. U.S.A.. 2014.10; 111 (40): E4254-E4263. ( PubMed, DOI )

  21. Hiroshi Ashida, Minsoo Kim, Chihiro Sasakawa. Exploitation of the host ubiquitin system by human bacterial pathogens. Nat. Rev. Microbiol.. 2014.06; 12 (6): 399-413. ( PubMed, DOI )

  22. Taira Kobayashi, Michinaga Ogawa, Takahito Sanada, Hitomi Mimuro, Minsoo Kim, Hiroshi Ashida, Reiko Akakura, Mitsutaka Yoshida, Magdalena Kawalec, Jean-Marc Reichhart, Tsunehiro Mizushima, Chihiro Sasakawa. The Shigella OspC3 effector inhibits caspase-4, antagonizes inflammatory cell death, and promotes epithelial infection. Cell Host Microbe. 2013.05; 13 (5): 570-583. ( PubMed, DOI )

  23. Hiroshi Ashida, Hiroyasu Nakano, Chihiro Sasakawa. Shigella IpaH0722 E3 ubiquitin ligase effector targets TRAF2 to inhibit PKC-NF-κB activity in invaded epithelial cells. PLoS Pathog.. 2013; 9 (6): e1003409. ( PubMed, DOI )

  24. Takahito Sanada, Minsoo Kim, Hitomi Mimuro, Hiroshi Ashida, Michinaga Ogawa, Tsunehiro Mizushima, Chihiro Sasakawa. A bacterial effector targets the TRAF6-NFκB pathway to modulate the acute inflammatory response to bacterial invasion of epithelial cells. Virulence. 2012.10; 3 (6): 518-521. ( PubMed, DOI )

  25. Takahito Sanada, Minsoo Kim, Hitomi Mimuro, Masato Suzuki, Michinaga Ogawa, Akiho Oyama, Hiroshi Ashida, Taira Kobayashi, Tomohiro Koyama, Shinya Nagai, Yuri Shibata, Jin Gohda, Jun-ichiro Inoue, Tsunehiro Mizushima, Chihiro Sasakawa. The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response. Nature. 2012.03; 483 (7391): 623-626. ( PubMed, DOI )

  26. Hiroshi Ashida, Michinaga Ogawa, Minsoo Kim, Hitomi Mimuro, Chihiro Sasakawa. Bacteria and host interactions in the gut epithelial barrier. Nat. Chem. Biol.. 2011.12; 8 (1): 36-45. ( PubMed, DOI )

  27. Hiroshi Ashida, Hitomi Mimuro, Michinaga Ogawa, Taira Kobayashi, Takahito Sanada, Minsoo Kim, Chihiro Sasakawa. Cell death and infection: a double-edged sword for host and pathogen survival. J. Cell Biol.. 2011.12; 195 (6): 931-942. ( PubMed, DOI )

  28. Hiroshi Ashida, Michinaga Ogawa, Hitomi Mimuro, Taira Kobayashi, Takahito Sanada, Chihiro Sasakawa. Shigella are versatile mucosal pathogens that circumvent the host innate immune system. Curr. Opin. Immunol.. 2011.08; 23 (4): 448-455. ( PubMed, DOI )

  29. Michinaga Ogawa, Hitomi Mimuro, Yuko Yoshikawa, Hiroshi Ashida, Chihiro Sasakawa. Manipulation of autophagy by bacteria for their own benefit. Microbiol. Immunol.. 2011.07; 55 (7): 459-471. ( PubMed, DOI )

  30. Nozomi Ishijima, Masato Suzuki, Hiroshi Ashida, Yusuke Ichikawa, Yumi Kanegae, Izumu Saito, Thomas Borén, Rainer Haas, Chihiro Sasakawa, Hitomi Mimuro. BabA-mediated adherence is a potentiator of the Helicobacter pylori type IV secretion system activity. J. Biol. Chem.. 2011.07; 286 (28): 25256-25264. ( PubMed, DOI )

  31. Michinaga Ogawa, Yuko Yoshikawa, Taira Kobayashi, Hitomi Mimuro, Makoto Fukumatsu, Kotaro Kiga, Zhenzi Piao, Hiroshi Ashida, Mitsutaka Yoshida, Shigeru Kakuta, Tomohiro Koyama, Yoshiyuki Goto, Takahiro Nagatake, Shinya Nagai, Hiroshi Kiyono, Magdalena Kawalec, Jean-Marc Reichhart, Chihiro Sasakawa. A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens. Cell Host Microbe. 2011.05; 9 (5): 376-389. ( PubMed, DOI )

  32. Hiroshi Ashida, Michinaga Ogawa, Minsoo Kim, Shiho Suzuki, Takahito Sanada, Claire Punginelli, Hitomi Mimuro, Chihiro Sasakawa. Shigella deploy multiple countermeasures against host innate immune responses. Curr. Opin. Microbiol.. 2011.02; 14 (1): 16-23. ( PubMed, DOI )

  33. Minsoo Kim, Hiroshi Ashida, Michinaga Ogawa, Yuko Yoshikawa, Hitomi Mimuro, Chihiro Sasakawa. Bacterial interactions with the host epithelium. Cell Host Microbe. 2010.07; 8 (1): 20-35. ( PubMed, DOI )

  34. Hiroshi Ashida, Minsoo Kim, Marc Schmidt-Supprian, Averil Ma, Michinaga Ogawa, Chihiro Sasakawa. A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKgamma to dampen the host NF-kappaB-mediated inflammatory response. Nat. Cell Biol.. 2010.01; 12 (1): 66-73; sup pp 1. ( PubMed, DOI )

  35. Hiroshi Ashida, Michinaga Ogawa, Hitomi Mimuro, Chihiro Sasakawa. Shigella infection of intestinal epithelium and circumvention of the host innate defense system. Curr. Top. Microbiol. Immunol.. 2009; 337 231-255. ( PubMed, DOI )

  36. Michinaga Ogawa, Yutaka Handa, Hiroshi Ashida, Masato Suzuki, Chihiro Sasakawa. The versatility of Shigella effectors. Nat. Rev. Microbiol.. 2008.01; 6 (1): 11-16. ( PubMed, DOI )

  37. Hiroki Iwai, Minsoo Kim, Yuko Yoshikawa, Hiroshi Ashida, Michinaga Ogawa, Yukihiro Fujita, Daniel Muller, Teruo Kirikae, Peter K Jackson, Shuji Kotani, Chihiro Sasakawa. A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling. Cell. 2007.08; 130 (4): 611-623. ( PubMed, DOI )

  38. Toshihiko Suzuki, Luigi Franchi, Claudia Toma, Hiroshi Ashida, Michinaga Ogawa, Yuko Yoshikawa, Hitomi Mimuro, Naohiro Inohara, Chihiro Sasakawa, Gabriel Nuñez. Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages. PLoS Pathog.. 2007.08; 3 (8): e111. ( PubMed, DOI )

  39. Hiroshi Ashida, Takahito Toyotome, Takeshi Nagai, Chihiro Sasakawa. Shigella chromosomal IpaH proteins are secreted via the type III secretion system and act as effectors. Mol. Microbiol.. 2007.02; 63 (3): 680-693. ( PubMed, DOI )

  40. Toshihiko Suzuki, Yuko Yoshikawa, Hiroshi Ashida, Hiroki Iwai, Takahito Toyotome, Hidenori Matsui, Chihiro Sasakawa. High vaccine efficacy against shigellosis of recombinant noninvasive Shigella mutant that expresses Yersinia invasin. J. Immunol.. 2006.10; 177 (7): 4709-4717. ( PubMed, DOI )

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Others 【 display / non-display 】

  • Shigella prevents infected cells from sacrificing themselves for the greater good，2020.08

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