Personnel Information

写真a

IKEDA Tohru


Job title

Professor

Research Areas, Keywords

Oral Pathology, Pathology, Bone metabolism, Ceramic bone substututes

Graduating School 【 display / non-display

  • Kagoshima University, Faculty of Dentistry, 1984.03, Graduated

Graduate School 【 display / non-display

  • Tokyo Medical and Dental University, Graduate School, Division of Dental Research, Doctor's Course, 1988.03, Completed

Campus Career 【 display / non-display

  • 1998.04
    -
    2004.09
    Tokyo Medical and Dental University, Faculty of Medicine, Pathology and Immunology, Junior Associate Professor
  • 2017.01
    -
    2018.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Oral Health Sciences, Oral Pathology, Professor
  • 2018.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Oral Health Sciences, Oral Pathology, Professor

External Career 【 display / non-display

  • 1988.10
    -
    1990.03
    , Assistant Professor
  • 1990.04
    -
    1998.03
    , Junior Associate Professor
  • 2004.10
    -
    2016.12
    , Professor

Research Areas 【 display / non-display

  • Oral biological science

Qualification Acquired 【 display / non-display

  • Dentist

 

Research Theme 【 display / non-display

  • Mechanism of inflitration of oral cancer

  • Mechanism of invasion and growth of odontogenic tumors and cysts

Published Papers & Misc 【 display / non-display

  1. Mochizuki Y, Tsuchiya M, Oyama J, Wada A, Kugimoto T, Kuroshima T, Hirai H, Tomioka H, Harada H, Ikeda T, Akashi T. Left supraclavicular (Virchow's) node metastasis detected before primary infradiaphragmatic tumor: a case series. Journal of medical case reports. 2022.01; 16 (1): 33. ( PubMed, DOI )

  2. ティーラウォン・チャンヤーヌット , 坂本 啓, 布川 裕規, 土谷 麻衣子, 栢森 高, 明石 巧, 濱垣 美和子, 富岡 博文, 黒嶋 雄志, 森田 圭一, 原田 浩之, 池田 通. 舌癌症例にみられるヒトパピローマウイルス(HPV)感染と無関係なp16免疫染色陽性反応(Immunohistochemical Positivity for p16 Unrelated to Human Papillomavirus(HPV) Infection in Lingual Squamous Cell Carcinomas) 口腔病学会雑誌. 2021.11; 88 (2-3): 115-126. ( ichushi )

  3. Kaida A, Yamamoto S, Parrales A, Young ED, Ranjan A, Alalem MA, Morita KI, Oikawa Y, Harada H, Ikeda T, Thomas SM, Diaz FJ, Iwakuma T. DNAJA1 promotes cancer metastasis through interaction with mutant p53. Oncogene. 2021.06; ( PubMed, DOI )

  4. Oikawa Yu, Tanaka Kae, Ohsako Toshimitsu, Kugimoto Takuma, Kuroshima Takeshi, Hirai Hideaki, Tomioka Hirofumi, Shimamoto Hiroaki, Michi Yasuyuki, Sakamoto Kei, Ikeda Tohru, Harada Hiroyuki. Comparison of Clinicopathological Characteristics Between the Anterior and Posterior Type of Squamous Cell Carcinoma of the Floor of the Mouth: The Anterior Type Is a Risk Factor for Multiple Primary Cancer FRONTIERS IN ONCOLOGY. 2021.06; 11 682428. ( PubMed, DOI )

  5. Yokokawa Misaki, Hirai Hideaki, Tran Cuong Minh, Fukuda Shuhei, Sakamoto Kei, Ikeda Tohru, Harada Hiroyuki. Adenoid cystic carcinoma metastasized from the maxilla to the mandible: A case report(和訳中) Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2021.05; 33 (3): 371-375. ( ichushi )

  6. Suga Takayuki, Tu Trang Thi Huyen, Takenoshita Miho, Mikuzuki Lou, Umezaki Yojiro, Shimamoto Hiroaki, Michi Yasuyuki, Hong Chaoli, Abiko Yoshihiro, Ikeda Tohru, Uzawa Narikazu, Harada Hiroyuki, Toyofuku Akira. Case Report: Hidden Oral Squamous Cell Carcinoma in Oral Somatic Symptom Disorder FRONTIERS IN PSYCHIATRY. 2021.04; 12 651871. ( PubMed, DOI )

  7. Shimono H, Hirai H, Oikawa Y, Mochizuki Y, Kuroshima T, Tomioka H, Kayamori K, Ikeda T, Harada H. Metastatic tumors in the oral region: a retrospective chart review of clinical characteristics and prognosis. Oral surgery, oral medicine, oral pathology and oral radiology. 2021.04; ( PubMed, DOI )

  8. Fukawa Yuki, Sakamoto Kei, Kugimoto Takuma, Michi Yasuyuki, Harada Hiroyuki, Yamamoto Masahide, Kitagawa Masanobu, Ikeda Tohru, Yamamoto Kouhei. Nodular lymphocyte-predominant Hodgkin lymphoma involving the hard palate PATHOLOGY INTERNATIONAL. 2021.03; 71 (3): 213-215. ( PubMed, DOI )

  9. Fukawa Yuki, Sakamoto Kei, Kugimoto Takuma, Michi Yasuyuki, Harada Hiroyuki, Yamamoto Masahide, Kitagawa Masanobu, Ikeda Tohru, Yamamoto Kouhei. Nodular lymphocyte-predominant Hodgkin lymphoma involving the hard palate(和訳中) Pathology International. 2021.03; 71 (3): 213-215. ( ichushi )

  10. Shibata E, Morita KI, Kayamori K, Tange S, Shibata H, Harazono Y, Michi Y, Ikeda T, Harada H, Imoto I, Yoda T. Detection of novel fusion genes by next-generation sequencing-based targeted RNA sequencing analysis in adenoid cystic carcinoma of head and neck. Oral surgery, oral medicine, oral pathology and oral radiology. 2021.03; ( PubMed, DOI )

  11. 布川 裕規, 坂本 啓, 釘本 琢磨, 道 泰之, 原田 浩之, 山本 正英, 北川 昌伸, 池田 通, 山本 浩平. 硬口蓋に発生したnodular lymphocyte-predominant Hodgkin lymphomaの一例(A case of nodular lymphocyte-predominant Hodgkin lymphoma involving the hard palate) 日本病理学会会誌. 2021.03; 110 (1): 274. ( ichushi )

  12. グエン・ファン・テーフィ , 坂本 啓, 池田 通. 舌疾患での異形成を分類する際に、口腔病理学者を補助するためのディープラーニングの利用(Deep-learning application for supporting oral pathologists in dysplasia grading of tongue lesions) 日本病理学会会誌. 2021.03; 110 (1): 264. ( ichushi )

  13. Baba Shunichi, Akashi Takumi, Kayamori Kou, Ohuchi Tomoyuki, Ogawa Ikuko, Kubota Nobuhisa, Nakano Keisuke, Nagatsuka Hitoshi, Hasegawa Hiromasa, Matsuzaka Kenichi, Tomii Shohei, Uchida Keisuke, Katsuta Noriko, Sekiya Takahiro, Ando Noboru, Miura Keiko, Ishibashi Hironori, Ariizumi Yousuke, Asakage Takahiro, Michi Yasuyuki, Harada Hiroyuki, Sakamoto Kei, Eishi Yoshinobu, Okubo Kenichi, Ikeda Tohru. Homeobox transcription factor engrailed homeobox 1 is a possible diagnostic marker for adenoid cystic carcinoma and polymorphous adenocarcinoma(和訳中) Pathology International. 2021.02; 71 (2): 113-123. ( ichushi )

  14. Kayamori Kou, Tsuchiya Maiko, Michi Yasuyuki, Kuribayashi Ami, Mikami Toshinari, Sakamoto Kei, Yoda Tetsuya, Ikeda Tohru. Primordial odontogenic tumor occurred in the maxilla with unique calcifications and its crucial points for differential diagnosis(和訳中) Pathology International. 2021.01; 71 (1): 80-87. ( ichushi )

  15. Chanyanuch Teerawong, Kei Sakamoto, Yuki Fukawa, Maiko Tsuchiya, Kou Kayamori, Takumi Akashi, Miwako Hamagaki, Hirofumi Tomioka, Takeshi Kuroshima, Kei-ichi Morita, Hiroyuki Harada, Tohru Ikeda. Immunohistochemical Positivity for p16 Unrelated to Human Papillomavirus (HPV) Infection in Lingual Squamous Cell Carcinomas The Journal of the Stomatological Society, Japan. 2021;

  16. Baba S, Akashi T, Kayamori K, Ohuchi T, Ogawa I, Kubota N, Nakano K, Nagatsuka H, Hasegawa H, Matsuzaka K, Tomii S, Uchida K, Katsuta N, Sekiya T, Ando N, Miura K, Ishibashi H, Ariizumi Y, Asakage T, Michi Y, Harada H, Sakamoto K, Eishi Y, Okubo K, Ikeda T. Homeobox transcription factor engrailed homeobox 1 is a possible diagnostic marker for adenoid cystic carcinoma and polymorphous adenocarcinoma. Pathology international. 2020.12; ( PubMed, DOI )

  17. Kayamori Kou, Tsuchiya Maiko, Michi Yasuyuki, Kuribayashi Ami, Mikami Toshinari, Sakamoto Kei, Yoda Tetsuya, Ikeda Tohru. Primordial odontogenic tumor occurred in the maxilla with unique calcifications and its crucial points for differential diagnosis PATHOLOGY INTERNATIONAL. 2020.10; ( PubMed, DOI )

  18. Nishii N, Shimamoto H, Ohsako T, Yokokawa M, Sato Y, Ohata Y, Kayamori K, Ikeda T, Harada H. Renal cell carcinoma metastasis to the maxillary bone successfully treated with surgery after vascular embolization: a case report. Journal of medical case reports. 2020.10; 14 (1): 193. ( PubMed, DOI )

  19. Shimamoto H, Hirota Y, Kashima Y, Kinoshita N, Yokokawa M, Ikeda T, Harada H. Granulocyte colony-stimulating factor-producing squamous cell carcinoma of the tongue exhibiting characteristic fluorine-18 deoxyglucose accumulation on positron emission tomography-computed tomography: A case report. World Journal Clinical Cases. 2020.05; 8 (9): 1666-1673. ( PubMed )

  20. ゲエン・ファン・テー・フィ , 坂本 啓, 池田 通. 舌の前癌病変を示唆する組織学的特徴を同定するためのディープラーニングの応用(Deep-learning application for identifying histological features suggestive of precancer in tongue) 日本病理学会会誌. 2020.03; 109 (1): 398. ( ichushi )

  21. Yukimori A, Tsuchiya M, Wada A, Michi Y, Kayamori K, Sakamoto K, Ikeda T. Genetic and histopathological analysis of a case of primary intraosseous carcinoma, NOS with features of both ameloblastic carcinoma and squamous cell carcinoma. World journal of surgical oncology. 2020.02; 18 (1): 45. ( PubMed, DOI )

  22. Yamamoto Daisuke, Kayamori Kou, Sakamoto Kei, Tsuchiya Maiko, Ikeda Tohru, Harada Hiroyuki, Yoda Tetsuya, Watabe Tetsuro, Hara-Yokoyama Miki. Intracellular claudin-1 at the invasive front of tongue squamous cell carcinoma is associated with lymph node metastasis(和訳中) Cancer Science. 2020.02; 111 (2): 700-712. ( ichushi )

  23. Shibata Eri, Morita Kei-ichi, Kayamori Kou, Maruiwa Mayuko, Michi Yasuyuki, Sato Yukiko, Takeuchi Kengo, Ikeda Tohru, Harada Hiroyuki, Yoda Tetsuya. Report Secretory carcinoma around Stensen's duct misdiagnosed as salivary duct cyst INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY. 2020; 13 (8): 2211-2217.

  24. Shibata E, Morita KI, Kayamori K, Maruiwa M, Michi Y, Sato Y, Takeuchi K, Ikeda T, Harada H, Yoda T. Secretory carcinoma around Stensen's duct misdiagnosed as salivary duct cyst. International journal of clinical and experimental pathology. 2020; 13 (8): 2211-2217. ( PubMed )

  25. Yokokawa Misaki, Morita Kei-ichi, Oikawa Yu, Kayamori Kou, Sakamoto Kei, Ikeda Tohru, Harada Hiroyuki. Co-expression of EGFR and MET has a synergistic effect on the prognosis of patients with oral squamous cell carcinoma JOURNAL OF ORAL PATHOLOGY & MEDICINE. 2019.12; 49 (3): 235-242. ( PubMed, DOI )

  26. Tsuchiya Maiko, Kayamori Kou, Wada Akane, Komaki Motohiro, Ohata Yae, Hamagaki Miwako, Sakamoto Kei, Ikeda Tohru. A Novel, Tumor-Induced Osteoclastogenesis Pathway Insensitive to Denosumab but Interfered by Cannabidiol INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2019.12; 20 (24): ( PubMed, DOI )

  27. 坂本 啓, 池田 通. 舌扁平上皮癌におけるp16発現の検討 日本口腔内科学会雑誌. 2019.12; 25 (2): 103. ( ichushi )

  28. Yamamura Kiyonobu, Ashida Hiroshi, Okano Tokuju, Kinoshita-Daitoku Ryo, Suzuki Shiho, Ohtani Kaori, Hamagaki Miwako, Ikeda Tohru, Suzuki Toshihiko. Inflammasome Activation Induced by Perfringolysin O of Clostridium perfringens and Its Involvement in the Progression of Gas Gangrene FRONTIERS IN MICROBIOLOGY. 2019.10; 10 2406. ( PubMed, DOI )

  29. Komiya Ruri, Wada Takahiro, Tsushima Fumihiko, Sakamoto Kei, Ikeda Tohru, Yamaguchi Akira, Harada Hiroyuki, Uo Motohiro. Quantitation and distribution of metallic elements in sequestra of medication-related osteonecrosis of jaw (MRONJ) using inductively coupled plasma atomic emission spectroscopy and synchrotron radiation X-ray fluorescence analysis JOURNAL OF BONE AND MINERAL METABOLISM. 2019.07; 37 (4): 676-684. ( PubMed, DOI )

  30. Komiya Ruri, Wada Takahiro, Tsushima Fumihiko, Sakamoto Kei, Ikeda Tohru, Yamagchi Akira, Harada Hiroyuki, Uo Motohiro. 誘導結合プラズマ原子発光分光法とシンクロトロン放射光X線蛍光解析を用いた薬剤関連性顎骨壊死(MRONJ)の腐骨における金属元素の定量と分布(Quantitation and distribution of metallic elements in sequestra of medication-related osteonecrosis of jaw(MRONJ) using inductively coupled plasma atomic emission spectroscopy and synchrotron radiation X-ray fluorescence analysis) Journal of Bone and Mineral Metabolism. 2019.07; 37 (4): 676-684. ( ichushi )

  31. Higuchi Y, Tsushima F, Sumikura K, Sato Y, Harada H, Kayamori K, Ikeda T. Diagnosis and treatment of oral focal mucinosis: a case series. Journal of medical case reports. 2019.04; 13 (1): 108. ( PubMed, DOI )

  32. 石田 尚子, 栢森 高, 坂本 啓, 行森 茜, 釘本 琢磨, 原田 浩之, 池田 通. 粘表皮癌におけるFUCA1の発現と病理組織診断への応用(The expression of FUCA1 in mucoepidermoide carcinoma and application to histopathological diagnosis) 日本病理学会会誌. 2019.04; 108 (1): 325. ( ichushi )

  33. Ishida Shoko, Kayamori Kou, Sakamoto Kei, Yukimori Akane, Kugimoto Takuma, Harada Hiroyuki, Ikeda Tohru. Alpha-L-fucosidase-1 is a diagnostic marker that distinguishes mucoepidermoid carcinoma from squamous cell carcinoma PATHOLOGY INTERNATIONAL. 2019.02; 69 (2): 76-85. ( PubMed, DOI )

  34. Wada Akane, Tsuchiya Maiko, Ozaki-Honda Yuu, Kayamori Kou, Sakamoto Kei, Yamaguchi Akira, Ikeda Tohru. A new osteoclastogenesis pathway induced by cancer cells targeting osteoclast precursor cells BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2019.01; 509 (1): 108-113. ( PubMed, DOI )

  35. Takada Kaho, Kuroshima Takeshi, Shimamoto Hiroaki, Ohsako Toshimitsu, Kayamori Kou, Ikeda Tohru, Harada Hiroyuki. Metastasis of lower gingival squamous cell carcinoma to buccinator lymph node: case report and review of the literature WORLD JOURNAL OF SURGICAL ONCOLOGY. 2019.01; 17 (1): 13. ( PubMed, DOI )

  36. Shimizu R, Tanaka K, Oikawa Y, Tomioka H, Kayamori K, Ikeda T, Yoshioka T, Ebihara A, Harada H. Epithelioid cell granuloma with caseating necrosis possibly caused by periapical periodontitis: a case report. Journal of medical case reports. 2018.12; 12 (1): 365. ( PubMed, DOI )

  37. Sawangarun Wanlada, Mandasari Masita, Aida Junko, Morita Kei-ichi, Kayamori Kou, Ikeda Tohru, Sakamoto Kei. Loss of Notch1 predisposes oro-esophageal epithelium to tumorigenesis EXPERIMENTAL CELL RESEARCH. 2018.11; 372 (2): 129-140. ( PubMed, DOI )

  38. Yae Ohata, Kou Kayamori, Akane Yukimori, Kanako Sumikura, Toshimitsu Ohsako, Hiroyuki Harada, Kei Sakamoto, Tohru Ikeda. A lesion categorized between ghost cell odontogenic carcinoma and dentinogenic ghost cell tumor with CTNNB1 mutation. Pathol. Int.. 2018.05; 68 (5): 307-312. ( PubMed, DOI )

  39. 大畑 八重, 土谷 麻衣子, 平井 秀明, 山口 聡, 明石 巧, 山口 朗, 池田 通, 栢森 高. 癌微小環境における線維芽細胞由来の白血病阻止因子(LIF)は口腔癌の浸潤に関与する(Fibroblast-derived leukemia inhibitory factor mediates invasion of oral squamous cell carcinoma) 日本病理学会会誌. 2018.04; 107 (1): 460. ( ichushi )

  40. Katase, N., Nishimatsu, S. I., Yamauchi, A., Yamamura, M., Terada, K., Itadani, M., Okada, N., Hassan, N. M. M., Nagatsuka, H., Ikeda, T., Nohno, T., Fujita, S.. DKK3 overexpression increases malignant properties of head and neck squamous cell carcinoma cells Oncology Research. 2018.01; 26 45-58. ( DOI )

  41. Minamizato, T., Koga, T., I, T., Nakatani, Y., Sumita, Y., Ikeda, T., Asahina, I.. Clinical application of autogenous partially demineralized dentin matrix prepared immediately after extraction for alveolar bone regeneration in implant dentistry: a pilot study International Journal of Oral and Maxillofacial Surgery. 2018.01; 47 125-132. ( DOI )

  42. Yae Ohata, Maiko Tsuchiya, Hideaki Hirai, Satoshi Yamaguchi, Takumi Akashi, Kei Sakamoto, Akira Yamaguchi, Tohru Ikeda, Kou Kayamori. Leukemia inhibitory factor produced by fibroblasts within tumor stroma participates in invasion of oral squamous cell carcinoma. PLoS ONE. 2018; 13 (2): e0191865. ( PubMed, DOI )

  43. Ozaki-Honda, Y., Seki, S., Fujiwara, M., Matsuura, M., Fujita, S., Ikeda, H., Umeda, M., Ayuse, T., Ikeda, T.. Prognostic prediction of oral squamous cell carcinoma by E-cadherin and N-cadherin expression in overall cells in tumor nests or tumor cells at the invasive front. Cancer Microenvironment. 2017.12; 14 87-94. ( DOI )

  44. Yae Ohata, Anna Tatsuzawa, Yoshio Ohyama, Ayako Ichikawa, Yumi Mochizuki, Sachiko Ishibashi, Yuri Itakura, Urara Sakurai, Kei Sakamoto, Tohru Ikeda, Masanobu Kitagawa, Kouhei Yamamoto. A distinctive subgroup of oral EBV+ B-cell neoplasm with polymorphous features is potentially identical to EBV+ mucocutaneous ulcer. Hum. Pathol.. 2017.11; 69 129-139. ( PubMed, DOI )

  45. Yamagata Y, Tomioka H, Sakamoto K, Sato K, Harada H, Ikeda T, Kayamori K. CD163-Positive Macrophages Within the Tumor Stroma Are Associated With Lymphangiogenesis and Lymph Node Metastasis in Oral Squamous Cell Carcinoma J Oral Maxillofac Surg. 2017.10; 75 (10): 2144-2153. ( DOI )

  46. Ikeda, T., Seki, S., Fujiwara, M, Matsuura, M., Ozaki, Y., Fujita, S., Ikeda, H., Umeda, M., Asahina, I.. Low-risk population among patients with TNM stages III and IV oral squamous cell carcinoma Oncology Letters. 2017.09; 14 3711-3716. ( DOI )

  47. 大畑 八重, 山本 浩平, 立澤 杏奈, 大山 厳雄, 市川 理子, 望月 裕美, 石橋 佐知子, 坂本 啓, 池田 通, 北川 昌伸. Epstein-Barr virus陽性口腔びまん性大細胞型B細胞性リンパ腫における臨床病理学的検討および遺伝子変異解析(Clinicopathologic and gene mutation analysis of EBV-positive oral diffuse large B-cell lymphoma) 日本病理学会会誌. 2017.09; 106 (2): 86. ( ichushi )

  48. Nakao, Y., Yamada, S., Yanamoto, S., Tomioka, T., Naruse, T., Ikeda, T., Kurita, H., Umeda, M.. Natriuretic peptide receptor A is related to the expression of vascular endothelial growth factors A and C, and is associated with the invasion potential of tongue squamous cell carcinoma International Journal of Oral and Maxillofacial Surgery. 2017.08; 46 1237-1242. ( DOI )

  49. Wanlada, S., Masita, M., Ikeda, T., Sakamoto, K.. Downregulation of Notch 1 expression in 4-nitroquinoline-1-oxide-induced precancers of mouse tongue. The Journal of the Stomatological Society, Japan. 2017.07; 84 84-92.

  50. サワンガルン・ワンラダ , マンダサリ・マシタ , 池田 通, 坂本 啓. 4-ニトロキノリン-1-オキシドによりマウス舌に誘発された前癌病変におけるNotch1の発現減弱(Downregulation of Notch1 Expression in 4-Nitroquinoline-1-oxide-Induced Precancers of Mouse Tongue) 口腔病学会雑誌. 2017.07; 84 (2): 84-92. ( ichushi )

  51. Yukimori, A., Oikawa, Y., Morita, K., Nguyen, C. T. K., Harada, H., Yamaguchi, S., Kayamori, K., Yamaguchi, A., Ikeda, T., Sakamoto, K.. Genetic basis of calcifying cystic odontogenic tumors. Plos One. 2017.06; 12 e0180224. ( DOI )

  52. Sakamoto, Y, Fujita, S., Adachi, M., Sakamoto, H., Naruse, T., Yanamoto, S., Ikeda, T., Umeda, M.. Carcinoma ex pleomorphic adenoma of the tongue: Difficulty in diagnosis between metastasis of breast cancer and salivary tumor Journal of Craniofacial Surgery. 2017.05; 28 e182-e185.

  53. Naruse, T., Yamashita, K., Yanamoto, S., Rokutanda, S., Matsushita, Y., Sakamoto, Y., Sakamoto, H., Ikeda, H., Ikeda, T., Asahina, I., Umeda, M.. Histopathological and immunohistochemical study in keratocystic odontogenic tumors: predictive factors of recurrence Oncology Letters. 2017.05; 13 3487-3493. ( DOI )

  54. Fujita, S., Ikeda, T.. The CCL2-CCR2 axis in lymph node metastasis from oral squamous cell carcinoma: an immunohistochemical study Journal of Oral and Maxillofacial Surgery. 2017.04; 75 742-749.

  55. Yamada Shin-ichi, Hayashida Saki, Fujita Shuichi, Ikeda Tohru, Kurita Hiroshi, Umeda Masahiro. 下顎骨の原発性黄色腫 1症例報告(Primary xanthoma of the mandible: a case report) Acta Medica Nagasakiensia. 2016.09; 60 (4): 161-164. ( ichushi )

  56. Ahmed Gazi Jased, Tatsukawa Eri, Morishita Kota, Shibata Yasuaki, Suehiro Fumio, Kamitakahara Masanobu, Yokoi Taishi, Koji Takehiko, Umeda Masahiro, Nishimura Masahiro, Ikeda Tohru. 骨格外インプラントモデルにおける破骨細胞と異物巨細胞の形成の調節と生物学的意義(Regulation and Biological Significance of Formation of Osteoclast and Foreign Body Giant Cells in an Extraskeletal Implantation Model) 日本歯科医師会雑誌. 2016.08; 69 (5): 510. ( ichushi )

  57. Morishita, K., Tatsukawa, E., Shibata, Y., Suehiro, F., Kamitakahara, M., Yokoi, T., Ioku, K., Umeda, M., Nishimura, M., Ikeda, T.. Diversity of multinucleated giant cells in extraskeletal implantation of hydroxyapatite with different microstructures Acta Biomaterialia. 2016.07; 39 180-191.

  58. Gazi, J. A., Tatsukawa, E., Morishita, K., Shibata, Y., Suehiro, F., Kamitakahara, M., Yokoi, T., Koji, T., Umeda, M, Nishimura, M, Ikeda, T.. Regulation and biological significance of formation of osteoclasts and foreign body giant cells in an extraskeletal implantation model Acta Histochemica et Cytochemica. 2016.06; 49 97-103.

  59. Ahmed Gazi Jased, Tatsukawa Eri, Morishita Kota, Shibata Yasuaki, Suehiro Fumio, Kamitakahara Masanobu, Yokoi Taishi, Koji Takehiko, Umeda Masahiro, Nishimura Masahiro, Ikeda Tohru. 皮下移植モデルにおける破骨細胞および異物巨細胞形成の制御と生物学的意義(Regulation and Biological Significance of Formation of Osteoclasts and Foreign Body Giant Cells in an Extraskeletal Implantation Model) Acta Histochemica et Cytochemica. 2016.06; 49 (3): 97-107. ( ichushi )

  60. Naruse, T., Yanamoto, S., Sakamoto, Y., Ikeda, T., Yamada, S.I., Umeda, M.. Clinicopathological study of primary intraosseous squamous cell carcinoma of the jaw and a review of the literature Journal of Oral and Maxillofacial Surgery. 2016.05; 74 2420-2427.

  61. Kamitakahara M, Tatsukawa E, Shibata Y, Umemoto S, Yokoi T, Ioku K, Ikeda T. Effect of silicate incorporation on in vivo responses of α-tricalcium phosphate ceramics. Journal of materials science. Materials in medicine. 2016.05; 27 (5): 97. ( PubMed, DOI )

  62. Yamada, S.-I., Hayashida, S., Fujira, S., Ikeda, T., Kurita, H., Umeda, M.. Primary xanthoma of the mandible Acta Medica Nagasakiensia. 2016.04; 60 161-164.

  63. Matsushita, Y., Fujita, S., Yanamoto, S., Yamada, S., Rokutanda, S., Yamashita, K., Ikeda, T., Umeda, M.. Spindle cell variant of ameloblastic carcinoma: a case report and literature review Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2016.03; 121 e54-e61.

  64. Matsushita, Y., Hayashida, S., Sakamoto, H., Naruse, T., Sakamoto, Y., Yanamoto, S., Fujita, S., Ikeda, T., Umeda, M.. Denosumab-related osteonecrosis of the jaw affects osteoclasts formation and differentiation: Pathological features of two cases Molecular and Clinical Oncology. 2016.02; 4 191-194.

  65. Matsushita Y, Hayashida S, Morishita K, Sakamoto H, Naruse T, Sakamoto Y, Yamada SI, Yanamoto S, Fujita S, Ikeda T, Umeda M. Denosumab-associated osteonecrosis of the jaw affects osteoclast formation and differentiation: Pathological features of two cases. Molecular and clinical oncology. 2016.02; 4 (2): 191-194. ( PubMed, DOI )

  66. Yamashita Hiromi, Fujita Shuichi, Ikeda Tohru, Asahina Izumi. 神経線維腫症患者の多発性歯原性嚢胞 ヌーナン症候群(Multiple odontogenic cysts in a patient with Neurofibromatosis-Noonan syndrome) Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2016.01; 28 (1): 51-54. ( ichushi )

  67. Naruse Tomofumi, Yanamoto Souichi, Matsushita Yuki, Hayashida Saki, Rokutanda Satoshi, Nakao Yuji, Ohmori Keisuke, Ikeda Tohru, Umeda Masahiro. 舌扁平上皮癌におけるポドプラニン発現の免疫組織学的研究 後発頸部リンパ節転移との相関(Immunohistochemical Study of Podoplanin Expression in Oral Tongue Squamous Cell Carcinomas: Correlation with the Delayed Cervical Lymph Node Metastasis) Oral Science in Japan. 2015.12; 2015 1-4. ( ichushi )

  68. Naruse, M., Yanamoto, S., Yamada, S., Takahashi, H., Matsushita, Y., Imayama, N., Ikeda, H., Shiraishi, T., Fujita, S., Ikeda, T., Asahina, I., Umeda, M.. Immunohistochemical Study of VEGF-C/VEGFR-3 Axis Expression in Oral Tongue Squamous Cell Carcinomas: Correlation with the Induction of Lymphangiogenesis Oncology Letters. 2015.10; 10 2027-2034.

  69. Naruse T, Yanamoto S, Yamada SI, Takahashi H, Matsushita Y, Imayama N, Ikeda H, Shiraishi T, Fujita S, Ikeda T, Asahina I, Umeda M. Immunohistochemical study of vascular endothelial growth factor-C/vascular endothelial growth factor receptor-3 expression in oral tongue squamous cell carcinoma: Correlation with the induction of lymphangiogenesis. Oncology letters. 2015.10; 10 (4): 2027-2034. ( PubMed, DOI )

  70. Matsushita Yuki, Fujita Shuichi, Kawasaki Goro, Rokutanda Satoshi, Yamashita Kentaro, Yanamoto Souichi, Ikeda Tohru, Umeda Masahiro. 井出らによる編集者への手紙に対する返信(Reply to letter to the editor by Ide et al.) Pathology International. 2015.10; 65 (10): 567. ( ichushi )

  71. Matsushita Y, Fujita S, Kawasaki G, Rokutanda S, Yamashita K, Yanamoto S, Ikeda T, Umeda M. Reply to letter to the editor by Ide et al. Pathology international. 2015.10; 65 (10): 567. ( PubMed, DOI )

  72. Yamamoto-Fukuda, T., Akiyama, N., Shibata, Y., Takahashi, H., Ikeda, T., Koji, T.. In vivo over-expression of KGF mimic human middle ear cholesteatoma European Archives of Otorhinolaryngology. 2015.08; 272 2689-2696.

  73. Watanabe, T., Kurata, S., Sanuki, T., Okayasu, I., Shibata, Y., Ikeda, T., Ayuse, T.. Protective effect of nitric oxide on liver circulation from ischemia reperfusion injury Journal of Investigative Surgery. 2015.08; 28 236-244.

  74. Imayama, N., Yamada, S., Yanamoto, S., Naruse, T., Matsushita, Y., Takahashi, H., Seki, S., Fujita, S., Ikeda, T., Umeda, M.. FOXC2 expression is associated with tumor proliferation and invasion potential in oral tongue squamous cell carcinoma Pathology & Oncology Research. 2015.07; 21 783-791.

  75. Rieder SA, Metidji A, Glass DD, Thornton AM, Ikeda T, Morgan BA, Shevach EM. Eos Is Redundant for Regulatory T Cell Function but Plays an Important Role in IL-2 and Th17 Production by CD4+ Conventional T Cells. Journal of immunology (Baltimore, Md. : 1950). 2015.07; 195 (2): 553-63. ( PubMed, DOI )

  76. Matsushita, Y., Yanamoto, S., Takahashi, H., Yamada, S., Naruse, T., Sakamoto, Y., Ikeda, H., Shiraishi, T., Fujita, S., Ikeda, T., Asahina, I., Umeda, M.. A clinicopathological study of perineural invasion and vascular invasion in oral tongue squamous cell carcinoma International Journal of Oral and Maxillofacial Surgery. 2015.05; 44 543-548.

  77. Shiraishi Takeshi, Uehara Masataka, Fujita Shuichi, Ikeda Tohru, Asahina Izumi. 小児患者における中心性歯原性線維腫の1症例 頭頂骨による下顎再建(A case of central odontogenic fibroma in a pediatric patient: Mandibular reconstruction with parietal bone) Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2015.05; 27 (3): 361-365. ( ichushi )

  78. Matsushita, Y., Fujita, S., Kawasaki, G., Hirota, Y., Rokutanda, S., Yamashita, K., Yanamoto, S., Ikeda, T., Umeda, M.. Granular cell ameloblastoma: Case report of a particular ameloblastoma histologically resembling oncocytoma Pathology International. 2015.01; 65 43-47.

  79. Seki, S., Fujiwara, M., Matsuura, M., Fujita, S., Ikeda, H., Umeda, M., Asahina, I., Ikeda, T.. Prognostic value of podoplanin expression in oral squamous cell carcinoma―a regression model auxiliary to UICC classification Pathology & Oncology Research. 2014.07; 20 521-528.

  80. Yanamoto, S., Yamada, S., Takahashi, H., Naruse, T., Matsushita, Y., Ikeda, H., Shiraishi, T., Seki, S., Fujita, S., Ikeda, T., Asahina, I., Umeda, M.. Expression of the cancer stem cell markers CD44v6 and ABCG2 in tongue cancer: Effect of neoadjuvant chemotherapy on local recurrence International Journal of Oncology. 2014.04; 44 1153-1162.

  81. Tatsukawa, E., Gonda, Y., Kamitakahara, M., Matsuura, M., Ushijima, M., Shibata, Y., Yonezawa, I., Fujiwara, M., Ioku, K., Ikeda, T.. Promotion of normal healing of bone defects under estrogen deficiency by implantation of beta-tricalcium phosphate composed of rod-shaped particles Journal of Orthopaedic Research. 2014.02; 32 189-196.

  82. Nakajima, K., Shibata, Y., Hishikawa, Y., Suematsu, T., Mori, M., Fukuhara, S., Koji, T., Sawase, T., Ikeda, T.. Coexpression of Ang1 and Tie2 in odontoblasts of mouse developing and mature teeth―a new insight into dentinogenesis Acta Histochemica et Cytochemica. 2014.02; 47 19-25.

  83. Kawasaki, G., Yanamoto, S., Yamada, S., Yoshitomi, I., Rokutanda, S., Kawano, T., Fujita, S., Ikeda, T., Umeda, M.. Soft masses occurring simultaneously in the upper and lower lips Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2014.02; 117 147-152.

  84. Ikeda, T., Kasai, M., Tatsukawa, E., Kamitakahara, M., Shibata, Y., Yokoi, T., Nemoto, T. K., Ioku, K.. A bone substitute with high affinity for vitamin D binding protein‒relationship to niche of osteoclasts Journal of Cellular and Molecular Medicine. 2014.01; 18 170-180.

  85. Yanamoto, S., Yamada, S., Takahashi, H., Kawasaki, G., Hisazumi, I., Shiraishi, T., Fujita, S., Ikeda, T., Asahina, I., Umeda, M.. Predictors of locoregional recurrence in T1-2N0 tongue cancer patients Pathology & Oncology Research. 2013.10; 19 795-803.

  86. Fujiyama, D., Yamamoto-Fukuda, T., Shibata, Y., Ikeda, T., Takahashi, H.. Observation of apoptosis and bone lamella structures in the human mastoid Otology & Neurotology. 2013.10; 34 1534-1542.

  87. Okada E, Araki A, Suzuki S, Watanabe H, Ikeda T, Watanabe T, Kurata M, Eishi Y, Watanabe M. Histological diagnosis of follicular lymphoma by biopsy of small intestinal normal mucosa. Dig Endosc. 2013.09; 25 (5): 544-546. ( PubMed, DOI )

  88. Ohba, S., Shiraishi, T., Minamizato, T., Ikeda, H., Fujita, S., Ikeda, T., Asahina, I.. Epithelium-poor odontogenic fibroma with an unusual progress Journal of Hard Tissue Biology. 2013; 22 383-388.

  89. Yamada, S., Yanamoto, S., Rokutanda, S., Matsutani, K., Kawasaki, G., Kawano, T., Fujita, S., Ikeda, T., Umeda, M.. Carcinoma ex pleomorphic adenoma in minor salivary glands of the anterior tongue: A case report Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2013; 25 197-200.

  90. Kawasaki, G., Yanamoto, S., Yoshitomi, I., Kawano, T., Mizuno, A., Hayashi, T., Fujita, S., Ikeda, T., Umeda, M.. Small cell carcinoma of the maxilla Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2013; 25 179-182.

  91. Yamada, S., Yanamoto, S., Kawakita, A., Kawasak, G., Fujita, S., Ikeda, T., Matsuo, T., Umeda, M.. Recurrent malignant melanoma of the palate successfully treated by gamma knife radiosurgery Oral Radiology. 2013; 29 170-175.

  92. Yanamoto, S., Yamada, S., Takahashi, H., Yoshitomi, I., Kawasaki, G., Minamizato, T., Shiraishi, T., Fujita, S., Ikeda, T., Asahina, I., Umeda, M.. Clinicopathological risk factors for local recurrence in oral squamous cell carcinoma International Journal of Oral and Maxillofacial Surgery. 2012.10; 41 1195-2000.

  93. Ikeda, T., Gonda, Y., Tatsukawa, E., Kasai, M., Shibata, Y., Kamitakahara, M., Okuda, T., Yonezawa, I., Kurosawa, H., Ioku, K.. Stimulation of osteogenesis in bone defects implanted with biodegradable hydroxyapatite composed of rod-shaped particles under mechanical unloading Acta Histochemica et Cytochemica. 2012.10; 45 283-292.

  94. Rokutanda, S., Yamada, S., Kawasaki, G., Kawano, T., Yanamoto, S., Fujita, S., Ikeda, T., Umeda, M.. Solitary neurofibroma of the maxillary sinus: Report of a case. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2012.08; 24 171-174. ( DOI )

  95. Fujita, S., Ikeda, T.. Cancer stem-like cells in adenoid cystic carcinoma of salivary glands: relationship with morphologenesis of histological variants Journal of Oral Pathology and Medicine. 2012.03; 41 207-213.

  96. Naruse, T., Yanamoto, S., Kawano, T., Yoshitomi, I., Yamada, S., Kawasaki, G., Fujita, S., Ikeda, T., Umeda, M.. Intramuscular lipoma of the tongue: Report of a case complicated with diffuse lipomatosis Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2012; 24 237-240.

  97. Yoshitomi, I., Kawasaki, G., Mizuno, A., Nishikido, M., Hayashi, T., Fujita, S., Ikeda, T.. Lingual metastasis as an initial presentation of renal cell carcinoma Medical Oncology. 2011.12; 28 1389-1394.

  98. Ono, D., Jimbo, R., Kawachi, G., Ioku, K., Ikeda, T., Sawase, T.. Lateral bone augmentation with newly developed beta-tricalcium phosphate block: an experimental study in the rabbit mandible Clinical Oral Implants Research. 2011.12; 22 1366-1372.

  99. Seki, S., Fujiwara, M., Matsuura, M., Fujita, S., Ikeda, H., Asahina, I., Ikeda, T.. Prediction of Outcome of Patients with Oral Squamous Cell Carcinoma Using Vascular Invasion and the Strongly Positive Expression of Vascular Endothelial Growth Factors Oral Oncology. 2011.07; 47 588-593.

  100. Fujita, S., Anami, M., Satoh, N., Yamashita, H., Asahina, I., Ikeda, T., Hayashi, T.. Cytopathologic features of secondary peripheral ameloblastic carcinoma: a case report Diagnostic Cytopathology. 2011.05; 39 354-358.

  101. Okumura, T., Gonda, Y., Ioku, K., Kamitakahara, M., Okuda, T., Yonezawa, I., Kurosawa, H., Asahina, I., Ikeda, T.. Behavior of beta-tricalcium phosphate granules composed of rod-shaped particles in the rat tibia Journal of the Ceramic Society of Japan. 2011; 119 101-104.

  102. Kasai, M., Tanida, I., Ueno, T., Kominami, E., Seki, S., Ikeda, T., Mizuochi, T.. Autophagic compartments gain access to the MHC class II-compartments in thymic epithelium Journal of Immunology. 2009.12; 183 7278-7285.

  103. Gonda, Y., Ioku, K., Shibata, Y., Okuda, T., Kawachi, G., Kamitakahara, M., Murayama, H., Hideshima, K., Kamihira, S., Yonezawa, I., Kurosawa, H., Ikeda, T.. Stimulatory effect of hydrothermally synthesized biodegradable hydroxyapatite granules on osteogenesis and direct association with osteoclasts Biomaterials. 2009.09; 30 4390-4400.

  104. Mikami, S., Katsube, K., Oya, M., Ishida, M., Kosaka, T., Mochizuki, S., Ikeda, T., Mukai, M., Okada, Y.. Increased RANKL expression is related to tumor migration and metastasis of renal cell carcinomas Journal of Pathology. 2009.08; 218 530-539.

  105. Ikeda, T.*, Fujita, S., Hatashi, T., Seki, S., Ikeda, H., Ikeda, M., Ikeda, H., Asahina, I.. Intraosseous carcinoma of the mandible composed of cells expressing myoepithelial cell-associated antigens: A case report and immunohistochemical analyses for the derivation Pathology International. 2008.07; 58 427-431.

  106. Okuda, T., Ioku, K., Yonezawa, I., Minagi, H., Gonda, Y., Kawachi, G., Kamitakahara, M., Shibata, Y., Murayama, H., Kurosawa, H., Ikeda, T.. The slow resorption with replacement by bone of a hydrothermally synthesized pure calcium-deficient hydroxyapatite Biomaterials. 2008.06; 29 2719-2728.

  107. Fujita, S., Senba, M., Kumatori, A., Hayashi, T., Ikeda, T., Toriyama, K.. Human papillomavirus infection in oral verrucous carcinoma: genotyping analysis and inverse correlation with p53 expression Pathobiology. 2008.06; 75 257-264.

  108. Sawase, T., Jimbo, R., Baba, K., Shibata, Y., Ikeda, T., Atsuta, M.. Photo-induced hydrophilicity enhances initial cell behavior and early bone apposition Clinical Oral Implants Research. 2008.05; 19 491-496.

  109. Fujita, S., Seki, S., Fujiwara, M., Ikeda, T.. Midkine expression correlating with growth activity and tooth morphogenesis in odontogenic tumors Human Pathology. 2008.05; 39 694-700.

  110. Jimbo, R., Sawase, T., Shibata, Y., Hirata, K., Hishikawa, Y., Tanaka, Y., Bessho, K., Ikeda, T., Atsuta, M.. Enhanced osseointegration by the chemotactic activity of plasma fibronectin for cellular fibronectin positive cells Biomaterials. 2007.08; 28 3469-3477.

  111. Okuda, T., Ioku, K., Yonezawa, I., Minagi, H., Kawachi, G., Gonda, Y., Murayama, H., Shibata, Y., Minami, S., Kamihira, S., Kurosawa, H., Ikeda, T.. The effect of the microstructure of beta-tricalcium phosphate on the metabolism of subsequently formed bone tissue Biomaterials. 2007.06; 28 2612-2621.

  112. Rokutanda, S., Yamada, S., Kawasaki, G., Kawano, T., Yanamoto, S., Fujita, S., Ikeda, T., Umeda, M.. Solitary neurofibroma of the maxillary sinus: Report of a case Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 24 (201200): 237-240.

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Conference Activities & Talks 【 display / non-display

  1. Pissacha Daroonpan, Naoto Nishii, Fumihiko Tsushima, Hiroyuki Harada, Tohru Ikeda, Miyuki Azuma. 舌扁平上皮癌における臨床転帰と免疫病理プロファイルによる包括的分析. 第81回日本癌学会学術総会 2022.09.29

  2. 1. Pissacha Daroonpan, 加島義久, 濱垣美和子, 西井直人, 津島文彦, 原田浩之, 池田 通, 東みゆき. 肉眼分類とがん浸潤様式からみた舌扁平上皮癌の免疫プロファイルの多様性. 第76回日本口腔科学会学術集会 2022.04.21

  3. Pissacha Daroonpan, 加島義久, 濱垣美和子, 西井直人, 津島文彦, 原田浩之, 池田 通, 東みゆき. マルチプレックス免疫組織染色による舌扁平上皮癌の免疫プロファイリング解析. 第66回口腔外科学会総会・学術大会 2021.11.12

  4. 土谷麻衣子、栢森 高、坂本 啓、池田 通. 口腔扁平上皮癌由来エクソソームによる新規の破骨細胞誘導経路とカンナビジオールによる阻害効果. 第110回日本病理学会総会 2021.04.23

  5. Nguyen Phan The Huy, Kei Sakamoto, Tohru Ikeda. Deep-learning application for supporting oral pathologists in dysplasia grading of tongue lesions. 第110回日本病理学会総会 2021.04.22

  6. 池田 通. 人工骨移植に対する生体反応と骨代謝. 第23回日本顎顔面インプラント学会 2019.12.01 つくば市

  7. Tohru Ikeda. Histopathologica Diagnosis of Odontogenic Tumors. KPPIKG2019 2019.10.11 Jakarta

  8. Tohru Ikeda. Functional bone substitutes for repairment of large bone defect and mechanism of bone destruction by oral squamous cell carcinoma. KPPIKG2019 2019.10.10 Jakarta

  9. Ohata Y, Tsuchiya M, Hirai H, Yamaguchi S, Akashi T, Sakamoto K, Yamaguchi A, Ikeda T, Kayamori K. Leukemia inhibitory factor produced by fibroblasts within tumor stroma participates in invasion of oral squamous cell carcinoma. Research and Clinical Excellence Day, University of California San Francisco 2017.10.12 California San Francisco

  10. 大畑八重、栢森高、 平井秀明、 土谷麻衣子、山口聡、原田浩之、坂本啓、池田通. 口腔扁平上皮癌における癌関連線維芽細胞の生物学的重要性 . 第28回日本臨床口腔病理学会総会・学術大会 2017.08.24 川越

  11. Uo M, Wada T, Komiya R, Harada H, Sakamoto K, Ikeda T, Yamaguchi A. Trace metallic element accumulation in the sequestrum of medication-related osteonecrosis of the jaw (MRONJ). 14th International Symposium on Applied Bioinorganic hemistry – ISABC14 June 7-10th 2017 2017.06.07 Toulouse, France

  12. Ioku K, Kamitakahara M, Kawagoe D, Ikeda T.. Calcium phosphate ceramics for regenerative medicine prepared through hydrothermal processing. 26th Annual Meeting of MRS-J 2016.12.19 Yokohama, Japan

  13. Ahmed GJ, Tatsukawa E, Morishita K, Shibata Y, Suehiro F, Kamitakahara M, Yokoi T, Koji T, Umeda M, Nishimura M, Ikeda T.. Regulation and biological significance of formation of osteoclast and foreign body giant cells in an extraskeletal implantation model. 第23回日本歯科医学会 2016.10.21

  14. Kamitakahara M, Shirato T, Yokoi T, Matsubara H, Shibata Y, Ikeda T.. Effect of silicate incorporation in alpha-tricalcium phosphate on behaviors of osteoblast-like cells. Bioceramics 28 2016.10.18 Charlotte, North Carolina, USA

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Campus class subject 【 display / non-display

  • General Pathology,2017 - Now

  • Oral Pathology,2017 - Now

Performance of duties 【 display / non-display

  • ,2020.04 - Now

  • ,2020.04 - Now

  • ,2018.04 - 2020.03