Personnel Information

写真a

YUI SHIRO


Job title

Associate Professor

Birth date

1977

Mail Address

yui.arm@tmd.ac.jp

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Graduating School 【 display / non-display 】

  • Keio University, Faculty of Medicine, 2002.03, Graduated

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Graduate School 【 display / non-display 】

  • Tokyo Medical and Dental University, Graduate School, Division of Medicine, Doctor's Course, 2011.03, Completed

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Campus Career 【 display / non-display 】

  • 2020.10
    -
    2022.02
    Tokyo Medical and Dental University， Institute of Research， Division of Advanced Research， Center for Stem Cell and Regenerative Medicine， Associate Professor
  • 2020.01
    -
    2020.09
    Tokyo Medical and Dental University， Institute of Research， Division of Advanced Research， Center for Stem Cell and Regenerative Medicine， Junior Associate Professor
  • 2017.10
    -
    2019.12
    Tokyo Medical and Dental University， Institute of Research， Division of Advanced Research， Center for Stem Cell and Regenerative Medicine， Assistant Professor
  • 2022.03
    -
    Now
    Tokyo Medical and Dental University， Institute of Research， a， Center for Stem Cell and Regenerative Medicine， Associate Professor
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External Career 【 display / non-display 】

  • 2020.10
    -
    Now
    , Associate Professor
  • 2020.01
    -
    2020.09
    , Junior Associate Professor
  • 2017.10
    -
    2019.12
    , Project Assistant Professor
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Research Areas 【 display / non-display 】

  • Gastroenterology

  • Cell biology

  • Tumor biology

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Qualification Acquired 【 display / non-display 】

  • Doctor

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Published Papers & Misc 【 display / non-display 】

  1. Nobuhiko Ogasawara, Yoshihito Kano, Yosuke Yoneyama, Sakurako Kobayashi, Satoshi Watanabe, Sakura Kirino, Fausto D Velez-Bravo, Yourae Hong, Aleksandra Ostapiuk, Pavlo Lutsik, Iichiroh Onishi, Shinichi Yamauchi, Yui Hiraguri, Go Ito, Yusuke Kinugasa, Kenichi Ohashi, Mamoru Watanabe, Ryuichi Okamoto, Sabine Tejpar, Shiro Yui. Discovery of non-genomic drivers of YAP signaling modulating the cell plasticity in CRC tumor lines. iScience. 2024.03; 27 (3): 109247. ( PubMed, DOI )

  2. Sylvia Leo, Yusuke Kato, Yu Meng Wu, Mutsumi Yokota, Masato Koike, Shiro Yui, Kiichiro Tsuchiya, Nobuaki Shiraki, Shoen Kume. The effect of Vitamin D3 and Valproic Acid on the maturation of human induced pluripotent stem cell-derived enterocyte-like cells. Stem Cells. 2023.05; ( PubMed, DOI )

  3. Sakurako Kobayashi, Nobuhiko Ogasawara, Satoshi Watanabe, Yosuke Yoneyama, Sakura Kirino, Yui Hiraguri, Masami Inoue, Sayaka Nagata, Yoshimi Okamoto-Uchida, Satoshi Kofuji, Hiromichi Shimizu, Go Ito, Tomohiro Mizutani, Shinichi Yamauchi, Yusuke Kinugasa, Yoshihito Kano, Yasuhiro Nemoto, Mamoru Watanabe, Kiichiro Tsuchiya, Hiroshi Nishina, Ryuichi Okamoto, Shiro Yui. Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation. Inflamm Regen. 2022.11; 42 (1): 49. ( PubMed, DOI )

  4. Pawel J Schweiger, Marie Le Bouteiller, Shiro Yui, Malte Thodberg, Ditte Clement, Kim B Jensen. Extracellular matrix interactions provide tumor cells with an escape mechanism for commitment to differentiation. Gastroenterology. 2022.08; ( PubMed, DOI )

  5. Satoshi Watanabe, Sakurako Kobayashi, Nobuhiko Ogasawara, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe, Kim B Jensen, Shiro Yui. Transplantation of intestinal organoids into a mouse model of colitis. Nat Protoc. 2022.02; 17 (3): 649-671. ( PubMed, DOI )

  6. Jordi Guiu, Edouard Hannezo, Shiro Yui, Samuel Demharter, Svetlana Ulyanchenko, Martti Maimets, Anne Jørgensen, Signe Perlman, Lene Lundvall, Linn Salto Mamsen, Agnete Larsen, Rasmus H Olesen, Claus Yding Andersen, Lea Langhoff Thuesen, Kristine Juul Hare, Tune H Pers, Konstantin Khodosevich, Benjamin D Simons, Kim B Jensen. Tracing the origin of adult intestinal stem cells. Nature. 2019.06; 570 (7759): 107-111. ( PubMed, DOI )

  7. Shiro Yui, Luca Azzolin, Martti Maimets, Marianne Terndrup Pedersen, Robert P Fordham, Stine L Hansen, Hjalte L Larsen, Jordi Guiu, Mariana R P Alves, Carsten F Rundsten, Jens V Johansen, Yuan Li, Chris D Madsen, Tetsuya Nakamura, Mamoru Watanabe, Ole H Nielsen, Pawel J Schweiger, Stefano Piccolo, Kim B Jensen. YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration. Cell Stem Cell. 2018.01; 22 (1): 35-49.e7. ( PubMed, DOI )

  8. Robert P Fordham, Shiro Yui, Nicholas R F Hannan, Christoffer Soendergaard, Alison Madgwick, Pawel J Schweiger, Ole H Nielsen, Ludovic Vallier, Roger A Pedersen, Tetsuya Nakamura, Mamoru Watanabe, Kim B Jensen. Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury. Cell Stem Cell. 2013.12; 13 (6): 734-744. ( PubMed, DOI )

  9. Shiro Yui, Tetsuya Nakamura, Toshiro Sato, Yasuhiro Nemoto, Tomohiro Mizutani, Xiu Zheng, Shizuko Ichinose, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Hans Clevers, Mamoru Watanabe. Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell. Nat. Med.. 2012.03; 18 (4): 618-623. ( PubMed, DOI )

  10. Satoshi Watanabe, Nobuhiko Ogasawara, Sakurako Kobayashi, Sakura Kirino, Masami Inoue, Yui Hiraguri, Sayaka Nagata, Hiromichi Shimizu, Go Ito, Tomohiro Mizutani, Yasuhiro Nemoto, Kiichiro Tsuchiya, Ryuichi Okamoto, Mamoru Watanabe, Shiro Yui. Organoids transplantation as a new modality to design epithelial signature to create a membrane-protective sulfomucin-enriched segment. J Gastroenterol. 2023.02; ( PubMed, DOI )

  11. Go Ito, Shiro Yui, Ryuichi Okamoto. A Cellular "Hub" Function to Resolve Colitis. Cell Mol Gastroenterol Hepatol. 2021.05; ( PubMed, DOI )

  12. Reiko Kuno, Go Ito, Ami Kawamoto, Yui Hiraguri, Hady Yuki Sugihara, Sayaka Takeoka, Sayaka Nagata, Junichi Takahashi, Mao Tsuchiya, Sho Anzai, Tomohiro Mizutani, Hiromichi Shimizu, Shiro Yui, Shigeru Oshima, Kiichiro Tsuchiya, Mamoru Watanabe, Ryuichi Okamoto. Notch and TNF-α signaling promote cytoplasmic accumulation of OLFM4 in intestinal epithelium cells and exhibit a cell protective role in the inflamed mucosa of IBD patients. Biochem Biophys Rep. 2021.03; 25 100906. ( PubMed, DOI )

  13. Tsuchiya M, Ito G, Hama M, Nagata S, Kawamoto A, Suzuki K, Shimizu H, Anzai S, Takahashi J, Kuno R, Takeoka S, Hiraguri Y, Sugihara HY, Mizutani T, Yui S, Oshima S, Tsuchiya K, Watanabe M, Okamoto R. Functional analysis of isoflavones using patient-derived human colonic organoids. Biochemical and biophysical research communications. 2021.01; 542 40-47. ( PubMed, DOI )

  14. Sho Anzai, Ami Kawamoto, Sayaka Nagata, Junichi Takahashi, Mao Kawai, Reiko Kuno, Sakurako Kobayashi, Satoshi Watanabe, Kohei Suzuki, Hiromichi Shimizu, Yui Hiraguri, Sayaka Takeoka, Hady Yuki Sugihara, Shiro Yui, Shigeru Oshima, Mamoru Watanabe, Ryuichi Okamoto. TGF-β promotes fetal gene expression and cell migration velocity in a wound repair model of untransformed intestinal epithelial cells. Biochem. Biophys. Res. Commun.. 2020.04; 524 (3): 533-541. ( PubMed, DOI )

  15. Ryuichi Okamoto, Hiromichi Shimizu, Kohei Suzuki, Ami Kawamoto, Junichi Takahashi, Mao Kawai, Sayaka Nagata, Yui Hiraguri, Sayaka Takeoka, Hady Yuki Sugihara, Shiro Yui, Mamoru Watanabe. Organoid-based regenerative medicine for inflammatory bowel disease. Regen Ther. 2020.03; 13 1-6. ( PubMed, DOI )

  16. Ami Kawamoto, Sayaka Nagata, Sho Anzai, Junichi Takahashi, Mao Kawai, Minami Hama, Daichi Nogawa, Kohei Yamamoto, Reiko Kuno, Kohei Suzuki, Hiromichi Shimizu, Yui Hiraguri, Shiro Yui, Shigeru Ohshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Kazuo Ohtsuka, Masanobu Kitagawa, Ryuichi Okamoto, Mamoru Watanabe. Ubiquitin D is up-regulated by synergy of Notch signalling and TNF-α in the inflamed intestinal epithelia of IBD patients. J Crohns Colitis. 2018.11; ( PubMed, DOI )

  17. Kohei Suzuki, Tatsuro Murano, Hiromichi Shimizu, Go Ito, Toru Nakata, Satoru Fujii, Fumiaki Ishibashi, Ami Kawamoto, Sho Anzai, Reiko Kuno, Konomi Kuwabara, Junichi Takahashi, Minami Hama, Sayaka Nagata, Yui Hiraguri, Kento Takenaka, Shiro Yui, Kiichiro Tsuchiya, Tetsuya Nakamura, Kazuo Ohtsuka, Mamoru Watanabe, Ryuichi Okamoto. Single cell analysis of Crohn's disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties. J. Gastroenterol.. 2018.09; 53 (9): 1035-1047. ( PubMed, DOI )

  18. Nobukatsu Horita, Kiichiro Tsuchiya, Ryohei Hayashi, Keita Fukushima, Shuji Hibiya, Masayoshi Fukuda, Yoshihito Kano, Tomohiro Mizutani, Yasuhiro Nemoto, Shiro Yui, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Fluorescent labelling of intestinal epithelial cells reveals independent long-lived intestinal stem cells in a crypt. Biochem Biophys Res Commun. 2014.10; 454 (4): 493-499. ( PubMed, DOI )

  19. Tatsuro Murano, Ryuichi Okamoto, Go Ito, Toru Nakata, Shuji Hibiya, Hiromichi Shimizu, Satoru Fujii, Yoshihito Kano, Tomohiro Mizutani, Shiro Yui, Junko Akiyama-Morio, Yasuhiro Nemoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells. Biochem Biophys Res Commun. 2014.01; 443 (3): 840-846. ( PubMed, DOI )

  20. Go Ito, Ryuichi Okamoto, Tatsuro Murano, Hiromichi Shimizu, Satoru Fujii, Toru Nakata, Tomohiro Mizutani, Shiro Yui, Junko Akiyama-Morio, Yasuhiro Nemoto, Eriko Okada, Akihiro Araki, Kazuo Ohtsuka, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Lineage-specific expression of bestrophin-2 and bestrophin-4 in human intestinal epithelial cells. PLoS ONE. 2013.11; 8 (11): e79693. ( PubMed, DOI )

  21. Tomohiro Mizutani, Tetsuya Nakamura, Ryo Morikawa, Masayoshi Fukuda, Wakana Mochizuki, Yuhki Yamauchi, Kengo Nozaki, Shiro Yui, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Mamoru Watanabe. Real-time analysis of P-glycoprotein-mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro. Biochem. Biophys. Res. Commun.. 2012.03; 419 (2): 238-243. ( PubMed, DOI )

  22. Junko Akiyama, Ryuichi Okamoto, Michiko Iwasaki, Xiu Zheng, Shiro Yui, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Delta-like 1 expression promotes goblet cell differentiation in Notch-inactivated human colonic epithelial cells. Biochem. Biophys. Res. Commun.. 2010.03; 393 (4): 662-667. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Shiro Yui. Fetal-like reprogramming is the key to understand the heterogeneity of colorectal cancer. SICS-OMICS2023, The 41st Sapporo International Cancer Symposium 2023.10.13 Tokyo, Japan

  2. Nobuhiko Ogasawara, Shiro Yui et al. ECM-niche dependent plasticity controls the acquisition of invasive phenotype in colorectal cancer. 第82回日本癌学会学術総会 2023.09.21 Yokohama

  3. Watanabe, Satoshi ; Ogasawara, Nobuhiko ; Kobayashi, Sakurako ; Ito, Go ; Kano, Yoshito ; Mizutani, Tomohiro ; Shimizu, Hiromichi ; Watanabe, Mamoru ; Okamoto, Ryuichi ; Yui, Shiro. APPLICATION OF DSS-GRAFTING ASSAY TO EVALUATE THE POTENTIAL OF CECUM ORGANOIDS AS A USEFUL CELLULAR SOURCE FOR THE TREATMENT OF COLITIS. Digestive Disease Week, 2022 2022.05.22 San Diego

  4. Sakurako Kobayashi, Satoshi Watanabe, Yosuke Yoneyama, Kousuke Tanimoto, Ryu Nishimura, Sayaka Nagata, Masami Inoue, Kouhei Suzuki, Sei Kakinuma, Kiichiro Tsuchiya, Ryuichi Okamoto, Mamoru Watanabe, Takanori Takebe, Shiro Yui. Conceptual basis of lineage shift between intestinal epithelium and hepatocytes. Keystone Symposia, Tissue Organoids as Models of Host Physiology and Pathophysiology of Disease 2020.01.22 Vancouver（Canada）

  5. Shiro Yui. Regenerative medicine in treatment of IBD. APDW 2019 2019.12.12 Kolkata (India)

  6. Shiro Yui, Mamoru Watanabe. Stem Cells in Gut, Who are They and How They Work, What Can We Count on Them. AOCC2019 2019.06.16 Taipei（Taiwan）

  7. Kawai M, Hama M, Nagata S, Kawamoto A, Suzuki K, Shimizu H, Anzai S, Takahashi J, Kuno R, Takeoka S, Hiraguri Y, Yui S, Okamoto R, Watanabe M. Functional analysis of isoflavones using patient-derived intestinal organoids. AOCC2019 2019.06.14 Taipei（Taiwan）

  8. Ryuichi Okamoto, Mao Kawai, Minami Hama, Sayaka Nagata, Ami Kawamoto, Kohei Suzuki, Hiromichi Shimizu, Sho Anzai, Junichi Takahashi, Reiko Kuno, Sayaka Takeoka, Yui Hiraguri, Shiro Yui, Mamoru Watanabe. 【The 6th JSGE International Topic Conference　Lifestyle-related Diseases in Gastroenterology】Gastrointestinal tract（role of gut microbiome and diet）. 第105回 日本消化器病学会総会 2019.05.10 ホテル日航金沢（石川県金沢市）

  9. Kawamoto A, Nagata S, Anzai S, Takahashi J, Kawai M, Hama M, Nogawa D, Yamamoto K, Kuno R, Suzuki K, Shimizu H, Hiraguri Y, Yui S, Oshima S, Tsuchiya K, Nakamura T, Ohtsuka K, Kitagawa M, Okamoto R, Watanabe M. Synergy of Notch signalling and TNF-α in the inflamed intestinal epithelia of IBD patients leads to up-regulation of UBD, a ubiquitin-like protein. ECCO2019 2019.03.08 Copenhagen（Denmark）

  10. Suzuki K, Shimizu H, Kawai M, Takahashi J, Anzai S, Kawamoto A, Nagata S, Hiraguri Y, Yui S, Tsuchiya K, Nakamura T, Ohtsuka K, Okamoto R, Watanabe M . UC-related and segment-specific properties of patientderived colonic organoids. ECCO2019 2019.03.07 Copenhagen（Denmark）

  11. Ishibashi F, Kuwabara K, Kawamoto A, Anzai S, Takahashi J, Nagata S, Shimizu H, Yui S, Oshima S, Tsuchiya K, Nakamura T, Watanabe M, Okamoto R. Ectopic expression of reg3a in the mice distal Colon is mediated by interactions between notch and Il-22 signaling pathways, and promotes tissue repair By the augmentation of EGFR signaling. UEGW 2018 2018.10.22 Vienna（Austria）

  12. Suzuki K, Takahashi J, Hiraguri Y, Yui S, Shimizu H, Tsuchiya K, Nakamura T, Ohtsuka K, Okamoto R, Watanabe M. . Crohn’s disease patient-derived small intestinal organoids reveal diseasestatus related modification of stem cell properties.. 5th TERMIS World Congress 2018 2018.09.07 Kyoto（JAPAN）

  13. Suzuki K, Murano T, Hiraguri Y, Takahashi J, Shimizu H,Anzai S, Kuwabara K, Kawamoto A, Ishibashi F, Yui S, Tsuchiya K, Nakamura T, Ohtsuka K, Watanabe M, Okamoto R... Crohn’s disease patient-derived small intestinal organoids reveal disease-status related modification of stem cell properties.. 5th TERMIS World Congress 2018 2018.09.06 Kyoto（JAPAN）

  14. Suzuki K, Kuwabara K, Takahashi J, Anzai S, Kuno R, Kawamoto A, Ishibashi F, Nagata S, Hiraguri Y, Yui S, Tsuchiya K, Nakamura T, Ohtsuka K, Okamoto R, Watanabe M.. Single-cell level analysis of organoids derived from CD patients reveals disease-status related modifications of small intestinal stem cells. DDW2018 2018.06.04 Washington D.C (USA）

  15. Shiro Yui,Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Fetalization of colonic epithelium medicated by YAP/TAZ links ECM remodeling to tissue regeneration. 16th Stem Cell Research Symposium 2018.06.02 Hyakunenn-Koudou, Kyushu University, Fukuoka（Japan）

  16. Shiro Yui, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Fetalization of colonic epithelium medicated by YAP/TAZ links ECM remodeling to tissue regeneration. GI Research Academy 2018 2018.05.25 Tokyo (Japan)

  17. Yui S (招待講演). Dissecting the molecular and cellular mechanisms responsible for tissue repair in inflammatory bowel disease.. First international conference on tissue repair, regeneration, and fibrosis. 2016.09.23 Rhodes, Greece

  18. Yui S, Guiu J, Schweigher P, Hanson G, Jensen K. Regional identity of cellular materials dictates the clinical potential in regenerative medicine for inflammatory bowel disease. . Stem Cell Niche conference, Development and Disease 2016.05.26 Favrholm, Denmark

  19. Yui Shiro Y, Jordi Guiu, Pawel Schweiger, Carsten Friis Rundsen, Kim Jensen. The Cellular Plasticity of Adult and Fetal Intestinal Epithelium and its functional Evaluation by Grafting Assay.. DDW2015 2015.05.16 Washington DC

  20. Shiro Yui, Jordi Guiu, Pawel Schweiger, Carsten Friis Rundsen, Kim Jensen. The Cellular Plasticity of Adult and Fetal Intestinal Epithelium and its functional Evaluation by Grafting Assay. DDW 2015 2015.05.16 Washington, D.C.

  21. 油井史郎、中村哲也、渡辺　守. マウスおよびヒトの正常な腸管上皮初代培養法の確立.. 第3回Japan Gut Forum 2012.11.24 東京

  22. Shiro Yui, Tetsuya Nakamura, Yasuhiro Nemoto, Tomohiro Mizutani, Masayoshi Fukuda, Kengo Nozaki, Yuuishi Yamauchi, Wakana Mochizuki, Xiu Zheng, Takashi Nagaichi, Ryuichi Okamoto, Kiishiro Ysuchiya, Mamoru Watanabe. 【Colon Stem Cell】Regeneration of damaged colon epithelium by transplanted colon Lgr5+ stem cells maintained and expanded in vitro. 第10回幹細胞シンポジウム 2012.06.01 淡路夢舞台国際会議場（兵庫県）

  23. Yui S. Regeneration of damaged colon epithelium by transplanted colon atem cells maintained and expanded in vitro.. The 5th Japan & US Collaboration Conference in Gastroenterology 2011.11.09 Tokyo

  24. Yui S, Nemoto Y, Mizutani T, Zheng X, Nagaishi T, Tsuchiya K, Watanabe M, Nakamura T, Okamoto R, Ichinose S, Sato T, Clevers H. Regeneration of damaged colonic tissue by transplanted colonic epithelial stem cells maintained and expanded in vitro.. GI Research Academy 2011 2011.06.17 Kyoto

  25. Yui S, Nakamura T, Nemoto Y, Mizutani T, Zheng X, Ichinose S, Nagaishi T, Okamoto R, Tsuchiya K, Sato T, Clevers H, Watanabe M. Regeneration of Damaged Colonic Tissue by Transplantation of Colonic Epithelial Stem Cells Maintained and Expanded In Vitro.. DDW2011 2011.05.07 McCormick Place（Chicago,USA）

  26. Yui S, Nakamura T, Nemoto Y, Mizutani T, Zheng X, Ichinose S, Nagaishi T, Okamoto R, Tsuchiya K, Watanabe M. A well-defined culture system for colonic epithelial cells thet allows efficient enrichment of LGR5+ stem cells. The 1st JSGE International Topic Conference 2010.09.25 Kamakura Park Hotel（Kanagawa Japan)

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Others 【 display / non-display 】

  • From grave to cradle: Collagen-induced gut cell reprogramming，2023.01

  • Infusion of 3D cellular structures might repair damaged intestine，2022.02

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