出身大学院 【 表示 / 非表示 】
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東京医科歯科大学 生命情報科学教育部 バイオ情報学専攻 修士課程 2011年03月 修了
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東京医科歯科大学 生命情報科学教育部 バイオ情報学専攻 博士課程 2014年03月 修了
経歴(学内) 【 表示 / 非表示 】
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2014年04月-2014年06月東京医科歯科大学 難治疾患研究所 発生再生生物学分野 特任助教
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2022年04月東京医科歯科大学 難治疾患研究所 難治病態研究部門 発生再生生物学分野 助教
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2022年05月-現在東京医科歯科大学 難治疾患研究所 未来生命科学研究部門 発生再生生物学分野 助教
経歴(学外) 【 表示 / 非表示 】
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2014年07月-2018年05月国立医薬品食品衛生研究所 医薬安全科学部 研究員
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2018年06月-2022年03月IQVIAサービシーズジャパン株式会社 Sr. MedDRA coordinator
競争的資金等の研究課題 【 表示 / 非表示 】
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ストレスシグナルによる概日リズム制御の分子メカニズムおよび生物学的意義の解明
文部科学省/日本学術振興会 : 2011年 - 2013年
論文・総説 【 表示 / 非表示 】
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Okamoto-Uchida Yoshimi, Nishimura Akari, Izawa Junko, Hattori Atsuhiko, Suzuki Nobuo, Hirayama Jun. The Use of Chemical Compounds to Identify the Regulatory Mechanisms of Vertebrate Circadian Clocks CURRENT DRUG TARGETS. 2020; 21 (5): 425-432. ( PubMed, DOI )
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Wang YH, Chen CB, Tassaneeyakul W, Saito Y, Aihara M, Choon SE, Lee HY, Chang MM, Roa FD, Wu CW, Zhang J, Nakkam N, Konyoung P, Okamoto-Uchida Y, Cheung CM, Huang JW, Ji C, Cheng B, Hui RC, Chu CY, Chen YJ, Wu CY, Hsu CK, Chiu TM, Huang YH, Lu CW, Yang CY, Lin YT, Chi MH, Ho HC, Lin JY, Yang CH, Chang YC, Su SC, Wang CW, Fan WL, Hung SI, Chung WH, Asian Severe Cutaneous Adverse Reaction Consortium.. The Medication Risk of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Asians: The Major Drug Causality and Comparison With the US FDA Label. Clinical pharmacology and therapeutics. 2019.01; 105 (1): 112-120. ( PubMed, DOI )
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Yu-Hsin Wang, Chun-Bing Chen, Wichittra Tassaneeyakul, Yoshiro Saito, Michiko Aihara, Siew Eng Choon, Haur Yueh Lee, Mimi Mee Chang, Francisca D Roa, Cheng-Wei Wu, Jing Zhang, Nontaya Nakkam, Parinya Konyoung, Yoshimi Okamoto-Uchida, Christina Man-Tung Cheung, Jin-Wen Huang, Chao Ji, Bo Cheng, Rosaline Chung-Yee Hui, Chia-Yu Chu, Yi-Ju Chen, Ching-Ying Wu, Chao-Kai Hsu, Tsu-Man Chiu, Yu-Huei Huang, Chun-Wei Lu, Chin-Yi Yang, Yi-Ting Lin, Min-Hui Chi, Hsin-Chun Ho, Jing-Yi Lin, Chih-Hsun Yang, Ya-Ching Chang, Shih-Chi Su, Chuang Wei Wang, Wen-Lang Fan, Shuen-Iu Hung, Wen-Hung Chung, . The Medication Risk of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Asians: The Major Drug Causality and Comparison With the US FDA Label. Clin Pharmacol Ther. 2019; 105 (1): 112-120.
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Okamoto-Uchida Y, Nakamura R, Matsunaga K, Aihara M, Saito Y. Specific association of the rs6500265 and rs9933632 single-nucleotide polymorphisms in Japanese patients with antipyretic analgesic-related Stevens-Johnson syndrome and toxic epidermal necrolysis with severe ocular involvements. Pharmacogenetics and genomics. 2018.03; 28 (3): 95-98. ( PubMed, DOI )
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岡本(内田)好海、中村亮介、斎藤嘉朗. 薬物アレルギーの発症機序 アレルギー・免疫. 2018; 25 (5): 92-97.
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Imatoh T, Sai K, Fukazawa C, Hinomura Y, Nakamura R, Okamoto-Uchida Y, Segawa K, Saito Y. Association between infection and severe drug adverse reactions: an analysis using data from the Japanese Adverse Drug Event Report database. European journal of clinical pharmacology. 2017.12; 73 (12): 1643-1653. ( PubMed, DOI )
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Okamoto-Uchida Yoshimi, Nakamura Ryosuke, Sai Kimie, Imatoh Takuya, Matsunaga Kayoko, Aihara Michiko, Saito Yoshiro. Stevens-Johnson症候群および中毒性表皮壊死症の病因に及ぼす感染症の影響(Effect of Infectious Diseases on the Pathogenesis of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis) Biological & Pharmaceutical Bulletin. 2017.09; 40 (9): 1576-1580. ( 医中誌 )
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Yamasaki T, Deki-Arima N, Kaneko A, Miyamura N, Iwatsuki M, Matsuoka M, Fujimori-Tonou N, Okamoto-Uchida Y, Hirayama J, Marth JD, Yamanashi Y, Kawasaki H, Yamanaka K, Penninger JM, Shibata S, Nishina H. Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. Scientific reports. 2017.08; 7 (1): 7348. ( PubMed, DOI )
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Okamoto-Uchida Y, Nakamura R, Sai K, Imatoh T, Matsunaga K, Aihara M, Saito Y. Effect of Infectious Diseases on the Pathogenesis of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Biological & pharmaceutical bulletin. 2017; 40 (9): 1576-1580. ( PubMed, DOI )
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Yoshimi Okamoto-Uchida, Ruoxing Yu, Norio Miyamura, Norie Arima, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Suguru Yoshida, Takamitsu Hosoya, Makiko Nawa, Takeshi Kasama, Yoichi Asaoka, Reiner Wimmer Alois, Ulrich Elling, Josef M Penninger, Sachiko Nishina, Noriyuki Azuma, Hiroshi Nishina. The mevalonate pathway regulates primitive streak formation via protein farnesylation. Sci Rep. 2016; 6 37697. ( PubMed, DOI )
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Yoshimi Okamoto-Uchida, Ryosuke Nakamura, Yumiko Matsuzawa, Megumi Soma, Hiroshi Kawakami, Akiko Ishii-Watabe, Tomoko Nishimaki-Mogami, Reiko Teshima, Yoshiro Saito. Different Results of IgE Binding- and Crosslinking-Based Allergy Tests Caused by Allergen Immobilization. Biol Pharm Bull. 2016; 39 (10): 1662-1666. ( PubMed, DOI )
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Franco H Falcone, Marcos J C Alcocer, Yoshimi Okamoto-Uchida, Ryosuke Nakamura. Use of humanized rat basophilic leukemia reporter cell lines as a diagnostic tool for detection of allergen-specific IgE in allergic patients: time for a reappraisal? Curr Allergy Asthma Rep. 2015.11; 15 (11): 67. ( PubMed, DOI )
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Nahoko Kaniwa, Mayumi Ueta, Ryosuke Nakamura, Yoshimi Okamoto-Uchida, Emiko Sugiyama, Keiko Maekawa, Yukitoshi Takahashi, Hirokazu Furuya, Akiko Yagami, Setsuko Matsukura, Zenro Ikezawa, Kayoko Matsunaga, Chie Sotozono, Michiko Aihara, Shigeru Kinoshita, Yoshiro Saito. Drugs causing severe ocular surface involvements in Japanese patients with Stevens-Johnson syndrome/toxic epidermal necrolysis. Allergol Int. 2015.10; 64 (4): 379-381. ( PubMed, DOI )
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Ruoxing Yu, Norio Miyamura, Yoshimi Okamoto-Uchida, Norie Arima, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Hiroshi Nishina. A Modified Murine Embryonic Stem Cell Test for Evaluating the Teratogenic Effects of Drugs on Early Embryogenesis. PLoS One. 2015; 10 (12): e0145286. ( PubMed, DOI )
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Keiko Maekawa, Ryosuke Nakamura, Nahoko Kaniwa, Seiho Mizusawa, Aya Kitamoto, Takuya Kitamoto, Maho Ukaji, Yumiko Matsuzawa, Emiko Sugiyama, Yoshimi Uchida, Kouichi Kurose, Mayumi Ueta, Chie Sotozono, Hiroko Ikeda, Akiko Yagami, Setsuko Matsukura, Shigeru Kinoshita, Masaaki Muramatsu, Zenro Ikezawa, Akihiro Sekine, Hirokazu Furuya, Yukitoshi Takahashi, Kayoko Matsunaga, Michiko Aihara, Yoshiro Saito, . Development of a simple genotyping method for the HLA-A*31:01-tagging SNP in Japanese. Pharmacogenomics. 2015; 16 (15): 1689-1699. ( PubMed, DOI )
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Norie Arima, Yoshimi Uchida, Ruoxing Yu, Koh Nakayama, Hiroshi Nishina. Acetylcholine receptors regulate gene expression that is essential for primitive streak formation in murine embryoid bodies. Biochem Biophys Res Commun. 2013.06; 435 (3): 447-453. ( PubMed, DOI )
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Ryosuke Nakamura, Ayano Ishiwatari, Masakazu Higuchi, Yoshimi Uchida, Rika Nakamura, Hiroshi Kawakami, Atsuo Urisu, Reiko Teshima. Evaluation of the luciferase assay-based in vitro elicitation test for serum IgE. Allergol Int. 2012.09; 61 (3): 431-437. ( PubMed, DOI )
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Yoshimi Uchida, Tomomi Osaki, Tokiwa Yamasaki, Tadanori Shimomura, Shoji Hata, Kazumasa Horikawa, Shigenobu Shibata, Takeshi Todo, Jun Hirayama, Hiroshi Nishina. Involvement of stress kinase mitogen-activated protein kinase kinase 7 in regulation of mammalian circadian clock. J Biol Chem. 2012.03; 287 (11): 8318-8326. ( PubMed, DOI )
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Yoshimi Uchida, Tadanori Shimomura, Jun Hirayama & Hiroshi Nishina. Light, Reactive Oxygen Species, and Magnetic Fields Activating ERK/MAPK Signaling Pathway in Cultured Zebrafish Cells Applyed Magnetic Resonance . 2011; 42 69-77.
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Tomomi Osaki, Yoshimi Uchida, Jun Hirayama, Hiroshi Nishina. Diphenyleneiodonium chloride, an inhibitor of reduced nicotinamide adenine dinucleotide phosphate oxidase, suppresses light-dependent induction of clock and DNA repair genes in zebrafish. Biol Pharm Bull. 2011; 34 (8): 1343-1347. ( PubMed, DOI )
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Ryosuke Nakamura, Y Uchida, M Higuchi, R Nakamura, I Tsuge, A Urisu, R Teshima. A convenient and sensitive allergy test: IgE crosslinking-induced luciferase expression in cultured mast cells. Allergy. 2010.10; 65 (10): 1266-1273. ( PubMed, DOI )
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Yoshimi Uchida, Jun Hirayama, Hiroshi Nishina. A common origin: signaling similarities in the regulation of the circadian clock and DNA damage responses. Biol Pharm Bull. 2010; 33 (4): 535-544. ( PubMed, DOI )
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Jun Hirayama, Norio Miyamura, Yoshimi Uchida, Yoichi Asaoka, Reiko Honda, Kenji Sawanobori, Takeshi Todo, Takuro Yamamoto, Paolo Sassone-Corsi, Hiroshi Nishina. Common light signaling pathways controlling DNA repair and circadian clock entrainment in zebrafish. Cell Cycle. 2009.09; 8 (17): 2794-2801. ( PubMed, DOI )
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Ryosuke Nakamura, Yoshimi Uchida, Masakazu Higuchi, Reiko Teshima. Development of a novel allergy test using a cultured mast cell line ImmunoTox Letter. 2009; 28 12-13.
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岡本(内田)好海 , 橋井 則貴, 中村 亮介, 斎藤 嘉朗. スティーヴンス・ジョンソン症候群/中毒性表皮壊死症の発症・重症化予測系の構築に向けて 臨床薬理の進歩. 2019.06; 40 140-149.
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Okamoto-Uchida Yoshimi, Izawa Junko, Nishimura Akari, Hattori Atsuhiko, Suzuki Nobuo, Hirayama Jun. Post-translational Modifications are Required for Circadian Clock Regulation in Vertebrates CURRENT GENOMICS. 2019; 20 (5): 332-339. ( PubMed, DOI )
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岡本(内田)好海、Yu Ruoxing, 仁科博史. ES細胞分化系を用いた簡便・高解像度な初期胚発生に対する医薬品リスク評価 ファルマシア. 2017; 53 (12): 1182-1186.
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岡本(内田)好海, 児玉 進, 中村 亮介, 斎藤 嘉朗. 臨床における重症薬疹とゲノムマーカー 谷本学校 毒性質問箱. 2015; 17 18-23.
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平山順, 内田好海, 宮村憲央, 沢登健治, 仁科博史. 概日リズムによる生理機能の制御機構 自律神経学会誌. 2010; 47 297-300.
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中村亮介, 内田好海, 樋口雅一, 手島玲子. 培養細胞を用いた新しいアレルギー検査方法の開発 日本免疫毒性学会誌. 2009; 28 2-5.
書籍等出版物 【 表示 / 非表示 】
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Izawa J, Okamoto-Uchida Y, Hirayama J . Chronobiology: The Science of Biological Time Structure. IntechOpen, 2019.05 Chapter3, Light-dependent regulation of circadian clocks in vertebrates.
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Okamoto-Uchida Y, Izawa J, Hirayama J. A Molecular Link between the Circadian Click, DNA Damage Responses, and Oncogene Activation. IntechOpen, 2018.11 Chapter2, A Molecular Link between the Circadian Click, DNA Damage Responses, and Oncogene Activation: Oncogenes and Carcinogenesis
講演・口頭発表等 【 表示 / 非表示 】
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斎藤 嘉朗, 岡本 好海, 中村 亮介. バイオ医薬品の免疫原性の臨床的評価 バイオ医薬品における免疫原性の臨床影響総論. 臨床薬理 2017.11.01
受賞学術賞 【 表示 / 非表示 】
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アズワン ビジネスコンテスト優勝,Wemake,2021年03月
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臨床薬理研究振興財団 研究大賞,公益財団法人 臨床薬理研究振興財団,2019年11月
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難治疾患研究所若手研究者研究発表会 第1位,2013年01月
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難治疾患研究所研究発表会 ベストプレゼンテーション賞,2011年01月
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難治疾患研究所研究発表会 ベストプレゼンテーション賞,東京医科歯科大学難治疾患研究所,2010年01月
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楽水会賞,一般社団法人 楽水会,2009年03月