Personnel Information

写真a

OKAMOTO YOSHIMI


Job title

Assistant Professor
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Graduating School 【 display / non-display 】

  • The Tokyo University of Marine Science and Technology, School of Marine Science, 2009.03, Graduated

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Graduate School 【 display / non-display 】

  • Tokyo Medical and Dental University, Bioinformatics, Master's Course, 2011.03, Completed

  • Tokyo Medical and Dental University, Bioinformatics, Doctor's Course, 2014.03, Completed

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Degree 【 display / non-display 】

  • Doctor of Science, Tokyo Medical and Dental University

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Campus Career 【 display / non-display 】

  • 2014.04
    -
    2014.06
    Tokyo Medical and Dental University， Medical Research Institute， Project Assistant Professor
  • 2022.04
    　
    　
    Tokyo Medical and Dental University， Medical Research Institute， Pathophysiology， Developmental and Regenerative Biology， Assistant Professor
  • 2022.05
    -
    Now
    Tokyo Medical and Dental University， Medical Research Institute， Division of Visionary Life Science， Department of Developmental and Regenerative Biology， Assistant Professor
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External Career 【 display / non-display 】

  • 2014.07
    -
    2018.05
    National Institute of Health Sciences, Division of Medical Safety Science,
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Research Theme 【 display / non-display 】

  • Elucidation of the mechanism of early onset of antipyretic analgesic-induced severe drug eruptions involving HLA, 2017.04 - 2019.03

  • Study of the mechanism and therapeutic biomarkers for sublingual immunotherapy by using the EXiLE method, 2016.04 - 2019.03

  • Study for mechanisms of drug-induced severe cutaneous reactions, 2015.03 - 2017.03

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Published Papers & Misc 【 display / non-display 】

  1. Jing Pu, Satoshi Kofuji, Yoshimi Okamoto-Uchida, Keiko Danzaki, Ruoxing Yu, Akira Suzuki, Satoshi Kitajima and Hiroshi Nishina. Lethal phenotype-based database screening identifies ceramide as a negative regulator of primitive streak formation Stem Cells. 2023;

  2. Kobayashi Sakurako, Ogasawara Nobuhiko, Watanabe Satoshi, Yoneyama Yosuke, Kirino Sakura, Hiraguri Yui, Inoue Masami, Nagata Sayaka, Okamoto-Uchida Yoshimi, Kofuji Satoshi, Shimizu Hiromichi, Ito Go, Mizutani Tomohiro, Yamauchi Shinichi, Kinugasa Yusuke, Kano Yoshihito, Nemoto Yasuhiro, Watanabe Mamoru, Tsuchiya Kiichiro, Nishina Hiroshi, Okamoto Ryuichi, Yui Shiro. Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation INFLAMMATION AND REGENERATION. 2022.11; 42 (1): 49. ( PubMed, DOI )

  3. Okamoto-Uchida Yoshimi, Nishimura Akari, Izawa Junko, Hattori Atsuhiko, Suzuki Nobuo, Hirayama Jun. The Use of Chemical Compounds to Identify the Regulatory Mechanisms of Vertebrate Circadian Clocks CURRENT DRUG TARGETS. 2020; 21 (5): 425-432. ( PubMed, DOI )

  4. Wang YH, Chen CB, Tassaneeyakul W, Saito Y, Aihara M, Choon SE, Lee HY, Chang MM, Roa FD, Wu CW, Zhang J, Nakkam N, Konyoung P, Okamoto-Uchida Y, Cheung CM, Huang JW, Ji C, Cheng B, Hui RC, Chu CY, Chen YJ, Wu CY, Hsu CK, Chiu TM, Huang YH, Lu CW, Yang CY, Lin YT, Chi MH, Ho HC, Lin JY, Yang CH, Chang YC, Su SC, Wang CW, Fan WL, Hung SI, Chung WH, Asian Severe Cutaneous Adverse Reaction Consortium.. The Medication Risk of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Asians: The Major Drug Causality and Comparison With the US FDA Label. Clinical pharmacology and therapeutics. 2019.01; 105 (1): 112-120. ( PubMed, DOI )

  5. Yu-Hsin Wang, Chun-Bing Chen, Wichittra Tassaneeyakul, Yoshiro Saito, Michiko Aihara, Siew Eng Choon, Haur Yueh Lee, Mimi Mee Chang, Francisca D Roa, Cheng-Wei Wu, Jing Zhang, Nontaya Nakkam, Parinya Konyoung, Yoshimi Okamoto-Uchida, Christina Man-Tung Cheung, Jin-Wen Huang, Chao Ji, Bo Cheng, Rosaline Chung-Yee Hui, Chia-Yu Chu, Yi-Ju Chen, Ching-Ying Wu, Chao-Kai Hsu, Tsu-Man Chiu, Yu-Huei Huang, Chun-Wei Lu, Chin-Yi Yang, Yi-Ting Lin, Min-Hui Chi, Hsin-Chun Ho, Jing-Yi Lin, Chih-Hsun Yang, Ya-Ching Chang, Shih-Chi Su, Chuang Wei Wang, Wen-Lang Fan, Shuen-Iu Hung, Wen-Hung Chung, . The Medication Risk of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Asians: The Major Drug Causality and Comparison With the US FDA Label. Clin Pharmacol Ther. 2019; 105 (1): 112-120.

  6. Okamoto-Uchida Y, Nakamura R, Matsunaga K, Aihara M, Saito Y. Specific association of the rs6500265 and rs9933632 single-nucleotide polymorphisms in Japanese patients with antipyretic analgesic-related Stevens-Johnson syndrome and toxic epidermal necrolysis with severe ocular involvements. Pharmacogenetics and genomics. 2018.03; 28 (3): 95-98. ( PubMed, DOI )

  7. Imatoh T, Sai K, Fukazawa C, Hinomura Y, Nakamura R, Okamoto-Uchida Y, Segawa K, Saito Y. Association between infection and severe drug adverse reactions: an analysis using data from the Japanese Adverse Drug Event Report database. European journal of clinical pharmacology. 2017.12; 73 (12): 1643-1653. ( PubMed, DOI )

  8. Okamoto-Uchida Yoshimi, Nakamura Ryosuke, Sai Kimie, Imatoh Takuya, Matsunaga Kayoko, Aihara Michiko, Saito Yoshiro. Stevens-Johnson症候群および中毒性表皮壊死症の病因に及ぼす感染症の影響(Effect of Infectious Diseases on the Pathogenesis of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis) Biological & Pharmaceutical Bulletin. 2017.09; 40 (9): 1576-1580. ( ichushi )

  9. Okamoto-Uchida Yoshimi, Nakamura Ryosuke, Sai Kimie, Imatoh Takuya, Matsunaga Kayoko, Aihara Michiko, Saito Yoshiro. Stevens-Johnson症候群および中毒性表皮壊死症の病因に及ぼす感染症の影響(Effect of Infectious Diseases on the Pathogenesis of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis) Biological & Pharmaceutical Bulletin. 2017.09; 40 (9): 1576-1580.

  10. Yamasaki T, Deki-Arima N, Kaneko A, Miyamura N, Iwatsuki M, Matsuoka M, Fujimori-Tonou N, Okamoto-Uchida Y, Hirayama J, Marth JD, Yamanashi Y, Kawasaki H, Yamanaka K, Penninger JM, Shibata S, Nishina H. Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. Scientific reports. 2017.08; 7 (1): 7348. ( PubMed, DOI )

  11. Okamoto-Uchida Y, Nakamura R, Sai K, Imatoh T, Matsunaga K, Aihara M, Saito Y. Effect of Infectious Diseases on the Pathogenesis of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Biological & pharmaceutical bulletin. 2017; 40 (9): 1576-1580. ( PubMed, DOI )

  12. Okamoto-Uchida Yoshimi, Nakamura Ryosuke, Matsuzawa Yumiko, Soma Megumi, Kawakami Hiroshi, Ishii-Watabe Akiko, Nishimaki-Mogami Tomoko, Teshima Reiko, Saito Yoshiro. アレルゲンの固定化に起因するIgE結合および架橋に基づいたアレルギー検査の異なる結果(Different Results of IgE Binding- and Crosslinking-Based Allergy Tests Caused by Allergen Immobilization) Biological & Pharmaceutical Bulletin. 2016.10; 39 (10): 1662-1666. ( ichushi )

  13. Yoshimi Okamoto-Uchida, Ruoxing Yu, Norio Miyamura, Norie Arima, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Suguru Yoshida, Takamitsu Hosoya, Makiko Nawa, Takeshi Kasama, Yoichi Asaoka, Reiner Wimmer Alois, Ulrich Elling, Josef M Penninger, Sachiko Nishina, Noriyuki Azuma, Hiroshi Nishina. The mevalonate pathway regulates primitive streak formation via protein farnesylation. Sci Rep. 2016; 6 37697. ( PubMed, DOI )

  14. Yoshimi Okamoto-Uchida, Ryosuke Nakamura, Yumiko Matsuzawa, Megumi Soma, Hiroshi Kawakami, Akiko Ishii-Watabe, Tomoko Nishimaki-Mogami, Reiko Teshima, Yoshiro Saito. Different Results of IgE Binding- and Crosslinking-Based Allergy Tests Caused by Allergen Immobilization. Biol Pharm Bull. 2016; 39 (10): 1662-1666. ( PubMed, DOI )

  15. Franco H Falcone, Marcos J C Alcocer, Yoshimi Okamoto-Uchida, Ryosuke Nakamura. Use of humanized rat basophilic leukemia reporter cell lines as a diagnostic tool for detection of allergen-specific IgE in allergic patients: time for a reappraisal? Curr Allergy Asthma Rep. 2015.11; 15 (11): 67. ( PubMed, DOI )

  16. Nahoko Kaniwa, Mayumi Ueta, Ryosuke Nakamura, Yoshimi Okamoto-Uchida, Emiko Sugiyama, Keiko Maekawa, Yukitoshi Takahashi, Hirokazu Furuya, Akiko Yagami, Setsuko Matsukura, Zenro Ikezawa, Kayoko Matsunaga, Chie Sotozono, Michiko Aihara, Shigeru Kinoshita, Yoshiro Saito. Drugs causing severe ocular surface involvements in Japanese patients with Stevens-Johnson syndrome/toxic epidermal necrolysis. Allergol Int. 2015.10; 64 (4): 379-381. ( PubMed, DOI )

  17. Kaniwa Nahoko, Ueta Mayumi, Nakamura Ryosuke, Okamoto-Uchida Yoshimi, Sugiyama Emiko, Maekawa Keiko, Takahashi Yukitoshi, Furuya Hirokazu, Yagami Akiko, Matsukura Setsuko, Ikezawa Zenro, Matsunaga Kayoko, Sotozono Chie, Aihara Michiko, Kinoshita Shigeru, Saito Yoshiro. Stevens-Johnson症候群/中毒性表皮壊死症の日本人患者において重症眼表面疾患を引き起こした薬物(Drugs causing severe ocular surface involvements in Japanese patients with Stevens-Johnson syndrome/toxic epidermal necrolysis) Allergology International. 2015.10; 64 (4): 379-381. ( ichushi )

  18. Ruoxing Yu, Norio Miyamura, Yoshimi Okamoto-Uchida, Norie Arima, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Hiroshi Nishina. A Modified Murine Embryonic Stem Cell Test for Evaluating the Teratogenic Effects of Drugs on Early Embryogenesis. PLoS One. 2015; 10 (12): e0145286. ( PubMed, DOI )

  19. Keiko Maekawa, Ryosuke Nakamura, Nahoko Kaniwa, Seiho Mizusawa, Aya Kitamoto, Takuya Kitamoto, Maho Ukaji, Yumiko Matsuzawa, Emiko Sugiyama, Yoshimi Uchida, Kouichi Kurose, Mayumi Ueta, Chie Sotozono, Hiroko Ikeda, Akiko Yagami, Setsuko Matsukura, Shigeru Kinoshita, Masaaki Muramatsu, Zenro Ikezawa, Akihiro Sekine, Hirokazu Furuya, Yukitoshi Takahashi, Kayoko Matsunaga, Michiko Aihara, Yoshiro Saito, . Development of a simple genotyping method for the HLA-A*31:01-tagging SNP in Japanese. Pharmacogenomics. 2015; 16 (15): 1689-1699. ( PubMed, DOI )

  20. Norie Arima, Yoshimi Uchida, Ruoxing Yu, Koh Nakayama, Hiroshi Nishina. Acetylcholine receptors regulate gene expression that is essential for primitive streak formation in murine embryoid bodies. Biochem Biophys Res Commun. 2013.06; 435 (3): 447-453. ( PubMed, DOI )

  21. Ryosuke Nakamura, Ayano Ishiwatari, Masakazu Higuchi, Yoshimi Uchida, Rika Nakamura, Hiroshi Kawakami, Atsuo Urisu, Reiko Teshima. Evaluation of the luciferase assay-based in vitro elicitation test for serum IgE. Allergol Int. 2012.09; 61 (3): 431-437. ( PubMed, DOI )

  22. Nakamura Ryosuke, Ishiwatari Ayano, Higuchi Masakazu, Uchida Yoshimi, Nakamura Rika, Kawakami Hiroshi, Urisu Atsuo, Teshima Reiko. ルシフェラーゼアッセイに基づいた血清中IgEのin vitro惹起試験の評価(Evaluation of the Luciferase Assay-Based In Vitro Elicitation Test for Serum IgE) Allergology International. 2012.09; 61 (3): 431-437. ( ichushi )

  23. Yoshimi Uchida, Tomomi Osaki, Tokiwa Yamasaki, Tadanori Shimomura, Shoji Hata, Kazumasa Horikawa, Shigenobu Shibata, Takeshi Todo, Jun Hirayama, Hiroshi Nishina. Involvement of stress kinase mitogen-activated protein kinase kinase 7 in regulation of mammalian circadian clock. J Biol Chem. 2012.03; 287 (11): 8318-8326. ( PubMed, DOI )

  24. Yoshimi Uchida, Tadanori Shimomura, Jun Hirayama & Hiroshi Nishina. Light, Reactive Oxygen Species, and Magnetic Fields Activating ERK/MAPK Signaling Pathway in Cultured Zebrafish Cells Applyed Magnetic Resonance . 2011; 42 69-77.

  25. Tomomi Osaki, Yoshimi Uchida, Jun Hirayama, Hiroshi Nishina. Diphenyleneiodonium chloride, an inhibitor of reduced nicotinamide adenine dinucleotide phosphate oxidase, suppresses light-dependent induction of clock and DNA repair genes in zebrafish. Biol Pharm Bull. 2011; 34 (8): 1343-1347. ( PubMed, DOI )

  26. Ryosuke Nakamura, Y Uchida, M Higuchi, R Nakamura, I Tsuge, A Urisu, R Teshima. A convenient and sensitive allergy test: IgE crosslinking-induced luciferase expression in cultured mast cells. Allergy. 2010.10; 65 (10): 1266-1273. ( PubMed, DOI )

  27. Uchida Yoshimi, Hirayama Jun, Nishina Hiroshi. 共通起源　体内時計の調節とDNA損傷反応における信号伝達の類似性(A Common Origin: Signaling Similarities in the Regulation of the Circadian Clock and DNA Damage Responses) Biological & Pharmaceutical Bulletin. 2010.04; 33 (4): 535-544. ( ichushi )

  28. Yoshimi Uchida, Jun Hirayama, Hiroshi Nishina. A common origin: signaling similarities in the regulation of the circadian clock and DNA damage responses. Biol Pharm Bull. 2010; 33 (4): 535-544. ( PubMed, DOI )

  29. Jun Hirayama, Norio Miyamura, Yoshimi Uchida, Yoichi Asaoka, Reiko Honda, Kenji Sawanobori, Takeshi Todo, Takuro Yamamoto, Paolo Sassone-Corsi, Hiroshi Nishina. Common light signaling pathways controlling DNA repair and circadian clock entrainment in zebrafish. Cell Cycle. 2009.09; 8 (17): 2794-2801. ( PubMed, DOI )

  30. Ryosuke Nakamura, Yoshimi Uchida, Masakazu Higuchi, Reiko Teshima. Development of a novel allergy test using a cultured mast cell line ImmunoTox Letter. 2009; 28 12-13.

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Books etc 【 display / non-display 】

  1. Izawa J, Okamoto-Uchida Y, Hirayama J . Chronobiology: The Science of Biological Time Structure. IntechOpen， 2019.05 Chapter3, Light-dependent regulation of circadian clocks in vertebrates.

  2. Okamoto-Uchida Y, Izawa J, Hirayama J. A Molecular Link between the Circadian Click, DNA Damage Responses, and Oncogene Activation. IntechOpen， 2018.11 Chapter2, A Molecular Link between the Circadian Click, DNA Damage Responses, and Oncogene Activation: Oncogenes and Carcinogenesis

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Conference Activities & Talks 【 display / non-display 】

  1. Okamoto-Uchida Yoshimi, Endo Yoshiki, Nishina Hiroshi. Molecular mechanism of YAP-dependent hepatocyte elimination. 第17回生命医科学研究所ネットワーク国際シンポジウム 2022.10.13 金沢

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