Personnel Information

写真a

Kay Tanita


Job title

Assistant Professor
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Graduating School 【 display / non-display 】

  • Tokyo Medical and Dental University, Faculty of Medicine, 2011.03, Graduated

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Graduate School 【 display / non-display 】

  • Tokyo Medical and Dental University, Doctor's Course, 2021.03, Completed

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Campus Career 【 display / non-display 】

  • 2017.04
    -
    2021.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Environmental Response， Pediatrics and Developmental Biology， Graduate Student
  • 2025.04
    -
    Now
    Institute of Science Tokyo， Offices under the Executive Board， Office of Global Affairs， Assistant Professor
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External Career 【 display / non-display 】

  • 2011.04
    -
    2017.03
    , Resident
  • 2022.06
    -
    2024.12
    Institut Imagine, Lymphocyte activation and susceptibility to EBV, Project Researcher
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Academic Society Affiliations 【 display / non-display 】

  • European society for immunodeficiency

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Qualification Acquired 【 display / non-display 】

  • Doctor

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Published Papers & Misc 【 display / non-display 】

  1. Sanami Takada, Tsubasa Okano, Kay Tanita, Kaima Tsukada, Masato Watanabe, Atsushi Hijikata, Takuya Naruto, Tzu-Wen Yeh, Saki Kasuga, Sadao Tokimasa, Mariko Taniguchi-Ikeda, Reina Ogata, Azusa Ikeda, Tomohide Goto, Hitoshi Osaka, Masatoshi Takagi, Kohsuke Imai, Tomohiro Morio, Mirjam van der Burg, Mikio Shimada, Hirokazu Kanegane. B-cell immunodeficiency associated with polynucleotide kinase 3'-phosphatase (PNKP) deficiency. J Allergy Clin Immunol Glob. 2025.08; 4 (3): 100514. ( PubMed, DOI )

  2. Tomomasa D, Tanita K, Hiruma Y, Hoshino A, Kudo K, Azumi S, Shiota M, Yamaoka M, Eguchi K, Ishimura M, Tanaka Y, Iwatsuki K, Okuno K, Hama A, Sakamoto KI, Taga T, Goto K, Ota H, Ichiki A, Kanda K, Miyamura T, Endo S, Ohnishi H, Sasahara Y, Arai A, Fournier B, Imadome KI, Morio T, Latour S, Kanegane H. Correction: Highly sensitive detection of Epstein-Barr virus-infected cells by EBER flow FISH. International journal of hematology. 2025.02; 121 (2): 284-285. ( PubMed, DOI )

  3. Dan Tomomasa, Kay Tanita, Yuriko Hiruma, Akihiro Hoshino, Ko Kudo, Shohei Azumi, Mitsutaka Shiota, Masayoshi Yamaoka, Katsuhide Eguchi, Masataka Ishimura, Yuka Tanaka, Keiji Iwatsuki, Keisuke Okuno, Asahito Hama, Ken-Ichi Sakamoto, Takashi Taga, Kimitoshi Goto, Haruka Ota, Akihiro Ichiki, Kaori Kanda, Takako Miyamura, Saori Endo, Hidenori Ohnishi, Yoji Sasahara, Ayako Arai, Benjamin Fornier, Ken-Ichi Imadome, Tomohiro Morio, Sylvain Latour, Hirokazu Kanegane. Highly sensitive detection of Epstein-Barr virus-infected cells by EBER flow FISH. Int J Hematol. 2024.05; 120 (2): 241-251. ( PubMed, DOI )

  4. Sakura F, Noma K, Asano T, Tanita K, Toyofuku E, Kato K, Tsumura M, Nihira H, Izawa K, Mitsui-Sekinaka K, Konno R, Kawashima Y, Mizoguchi Y, Karakawa S, Hayakawa S, Kawaguchi H, Imai K, Nonoyama S, Yasumi T, Ohnishi H, Kanegane H, Ohara O, Okada S. A complementary approach for genetic diagnosis of inborn errors of immunity using proteogenomic analysis. PNAS nexus. 2023.04; 2 (4): pgad104. ( PubMed, DOI )

  5. Kaneko S, Sakura F, Tanita K, Shimbo A, Nambu R, Yoshida M, Umetsu S, Inui A, Okada C, Tsumura M, Yamada M, Suzuki H, Kosaki K, Ohara O, Shimizu M, Morio T, Okada S, Kanegane H. Janus kinase inhibitors ameliorate clinical symptoms in patients with STAT3 gain-of-function. Immunotherapy advances. 2023; 3 (1): ltad027. ( PubMed, DOI )

  6. Tomomasa D, Hiejima E, Miyamoto T, Tanita K, Matsuoka M, Niizato D, Mitsuiki N, Isoda T, Yasumi T, van Zelm MC, Morio T, Kanegane H. Recurrent tandem duplication of UNC13D in familial hemophagocytic lymphohistiocytosis type 3. Clinical immunology (Orlando, Fla.). 2022.09; 242 109104. ( PubMed, DOI )

  7. Sbihi Z, Tanita K, Bachelet C, Bole C, Jabot-Hanin F, Tores F, Le Loch M, Khodr R, Hoshino A, Lenoir C, Oleastro M, Villa M, Spossito L, Prieto E, Danielian S, Brunet E, Picard C, Taga T, Abdrabou SSMA, Isoda T, Yamada M, Palma A, Kanegane H, Latour S. Identification of Germline Non-coding Deletions in XIAP Gene Causing XIAP Deficiency Reveals a Key Promoter Sequence. Journal of clinical immunology. 2022.04; 42 (3): 559-571. ( PubMed, DOI )

  8. Tomomasa D, Tanita K, Higashi S, Tasaka Y, Shimamura T, Sakurai U, Matsubara T, Okada S, Morio T, Kanegane H. Early diagnosis of partial interferon-γ receptor 1 deficiency prevents the development of Bacille de Calmette et Guérin osteomyelitis. Clinical immunology (Orlando, Fla.). 2022.02; 235 108933. ( PubMed, DOI )

  9. Tanita K, Kawamura Y, Miura H, Mitsuiki N, Tomoda T, Inoue K, Iguchi A, Yamada M, Yoshida T, Muramatsu H, Tada N, Matsui T, Kato M, Eguchi K, Ishimura M, Ohga S, Imai K, Morio T, Yoshikawa T, Kanegane H. Case Report: Rotavirus Vaccination and Severe Combined Immunodeficiency in Japan. Frontiers in immunology. 2022; 13 786375. ( PubMed, DOI )

  10. Karasawa T, Kudo K, Tanita K, Takahashi Y, Kanegane H, Terui K. Epstein-Barr Virus-Negative Granulomatous Disease Due to SAP Deficiency. Journal of clinical immunology. 2021.08; 41 (6): 1372-1375. ( PubMed, DOI )

  11. Tanita K, Sakura F, Nambu R, Tsumura M, Imanaka Y, Ohnishi H, Kato Z, Pan J, Hoshino A, Suzuki K, Yasutomi M, Umetsu S, Okada C, Takagi M, Imai K, Ohara O, Muise AM, Okada S, Morio T, Kanegane H. Clinical and Immunological Heterogeneity in Japanese Patients with Gain-of-Function Variants in STAT3. Journal of clinical immunology. 2021.05; 41 (4): 780-790. ( PubMed, DOI )

  12. Tanita K, Sakura F, Nambu R, Tsumura M, Imanaka Y, Ohnishi H, Kato Z, Pan J, Hoshino A, Suzuki K, Yasutomi M, Umetsu S, Okada C, Takagi M, Imai K, Ohara O, Muise AM, Okada S, Morio T, Kanegane H. Correction to: Clinical and Immunological Heterogeneity in Japanese Patients with Gain-of-Function Variants in STAT3. Journal of clinical immunology. 2021.05; 41 (4): 791-794. ( PubMed, DOI )

  13. Yeh TW, Okano T, Naruto T, Yamashita M, Okamura M, Tanita K, Du L, Pan-Hammarström Q, Mitsuiki N, Okada S, Kanegane H, Imai K, Morio T. APRIL-dependent lifelong plasmacyte maintenance and immunoglobulin production in humans. The Journal of allergy and clinical immunology. 2020.11; 146 (5): 1109-1120.e4. ( PubMed, DOI )

  14. Okano T, Imai K, Naruto T, Okada S, Yamashita M, Yeh TW, Ono S, Tanaka K, Okamoto K, Tanita K, Matsumoto K, Toyofuku E, Kumaki-Matsumoto E, Okamura M, Ueno H, Ogawa S, Ohara O, Takagi M, Kanegane H, Morio T. Whole-Exome Sequencing-Based Approach for Germline Mutations in Patients with Inborn Errors of Immunity. Journal of clinical immunology. 2020.07; 40 (5): 729-740. ( PubMed, DOI )

  15. Inoue K, Miura H, Hoshino A, Kamiya T, Tanita K, Ohye T, Park MJ, Yanagimachi M, Takagi M, Imai K, Morio T, Yoshikawa T, Kanegane H. Inherited chromosomally integrated human herpesvirus-6 in a patient with XIAP deficiency. Transplant infectious disease : an official journal of the Transplantation Society. 2020.05; e13331. ( PubMed, DOI )

  16. 大原智子, 宮井健太郎, 谷田けい, 平石知佳, 福山希央, 田村英一郎, 河合利尚, 今井耕輔, 金兼弘和, 清原鋼二. リファンピシン投与に関連してマクロファージ活性化症候群を合併した慢性肉芽腫症 日本小児科学会雑誌. 2020.05; 124 (5): 838-844.

  17. Nishikawa T, Okamura K, Moriyama M, Watanabe K, Ibusuki A, Sameshima S, Masamoto I, Yamazaki I, Tanita K, Kanekura T, Kanegane H, Suzuki T, Kawano Y. Novel AP3B1 compound heterozygous mutations in a Japanese patient with Hermansky-Pudlak syndrome type 2. The Journal of dermatology. 2020.02; 47 (2): 185-189. ( PubMed, DOI )

  18. Okumura T, Horie Y, Lai CY, Lin HT, Shoda H, Natsumoto B, Fujio K, Kumaki E, Okano T, Ono S, Tanita K, Morio T, Kanegane H, Hasegawa H, Mizoguchi F, Kawahata K, Kohsaka H, Moritake H, Nunoi H, Waki H, Tamaru SI, Sasako T, Yamauchi T, Kadowaki T, Tanaka H, Kitanaka S, Nishimura K, Ohtaka M, Nakanishi M, Otsu M. Robust and highly efficient hiPSC generation from patient non-mobilized peripheral blood-derived CD34<sup>+</sup> cells using the auto-erasable Sendai virus vector. Stem cell research & therapy. 2019.06; 10 (1): 185. ( PubMed, DOI )

  19. Tanita Kay, Hoshino Akihiro, Imadome Ken-Ichi, Kamiya Takahiro, Inoue Kento, Okano Tsubasa, Yeh Tzu-wen, Yanagimachi Masakatsu, Shiraishi Akira, Ishimura Masataka, Schober Tilmann, Rohlfs Meino, Takagi Masatoshi, Imai Kohsuke, Takada Hidetoshi, Ohga Shouichi, Klein Christoph, Morio Tomohiro, Kanegane Hirokazu. Epstein-Barr Virus-Associated gamma delta T-Cell Lymphoproliferative Disorder Associated With Hypomorphic IL2RG Mutation. FRONTIERS IN PEDIATRICS. 2019.02; 7 ( DOI )

  20. Hoshino A, Yang X, Tanita K, Yoshida K, Ono T, Nishida N, Okuno Y, Kanzaki T, Goi K, Fujino H, Ohshima K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Kojima S, Morio T, Kanegane H. Modification of cellular and humoral immunity by somatically reverted T cells in X-linked lymphoproliferative syndrome type 1. The Journal of allergy and clinical immunology. 2019.01; 143 (1): 421-424.e11. ( PubMed, DOI )

  21. Cardinez C, Miraghazadeh B, Tanita K, da Silva E, Hoshino A, Okada S, Chand R, Asano T, Tsumura M, Yoshida K, Ohnishi H, Kato Z, Yamazaki M, Okuno Y, Miyano S, Kojima S, Ogawa S, Andrews TD, Field MA, Burgio G, Morio T, Vinuesa CG, Kanegane H, Cook MC. Gain-of-function <i>IKBKB</i> mutation causes human combined immune deficiency. The Journal of experimental medicine. 2018.11; 215 (11): 2715-2724. ( PubMed, DOI )

  22. Hoshino A, Tanita K, Kanda K, Imadome KI, Shikama Y, Yasumi T, Imai K, Takagi M, Morio T, Kanegane H. High frequencies of asymptomatic Epstein-Barr virus viremia in affected and unaffected individuals with CTLA4 mutations. Clinical immunology (Orlando, Fla.). 2018.10; 195 45-48. ( PubMed, DOI )

  23. Okano T, Tsujita Y, Kanegane H, Mitsui-Sekinaka K, Tanita K, Miyamoto S, Yeh TW, Yamashita M, Terada N, Ogura Y, Takagi M, Imai K, Nonoyama S, Morio T. Droplet Digital PCR-Based Chimerism Analysis for Primary Immunodeficiency Diseases. Journal of clinical immunology. 2018.04; 38 (3): 300-306. ( PubMed, DOI )

  24. Petersheim D, Massaad MJ, Lee S, Scarselli A, Cancrini C, Moriya K, Sasahara Y, Lankester AC, Dorsey M, Di Giovanni D, Bezrodnik L, Ohnishi H, Nishikomori R, Tanita K, Kanegane H, Morio T, Gelfand EW, Jain A, Secord E, Picard C, Casanova JL, Albert MH, Torgerson TR, Geha RS. Mechanisms of genotype-phenotype correlation in autosomal dominant anhidrotic ectodermal dysplasia with immune deficiency. The Journal of allergy and clinical immunology. 2018.03; 141 (3): 1060-1073.e3. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. 1) Miko Okamura, Kay Tanita, Hidetoshi Takada, Tetsuo Mitsui, Yoshiyuki Minegishi, Kohsuke Imai, Tomohiro Morio, Hirokazu Kanegane. Somatically reverted T cells in dedicator of cytokinesis 8 deficiency modify cellular immunity. 3rd Scientific Congress of Asia Pacific Society for Immunodeficiencies 2020.02.09 Chandigarh, India

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