Personnel Information

写真a

Tanaka Hikari


Job title

Associate Professor

Birth date

1993
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Campus Career 【 display / non-display 】

  • 2015.04
    -
    2017.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Neuropathology， Graduate Student
  • 2017.04
    -
    2020.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Neuropathology， Graduate Student
  • 2021.06
    -
    2022.04
    Tokyo Medical and Dental University， Medical Research Institute， Pathophysiology， Neuropathology， Assistant Professor
  • 2022.05
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    2024.09
    Tokyo Medical and Dental University， Medical Research Institute， Division of Advanced Pathophysiological Science， Department of Neuropathology， Junior Associate Professor
  • 2022.05
    -
    Now
    Institute of Science Tokyo， Medical Research Institute， Pathophysiology， Neuropathology， Junior Associate Professor
  • 2024.10
    -
    2025.03
    Institute of Science Tokyo， -， Institute of Integrated Research， Advanced Pathophysiological Science， Department of Neuropathology， Junior Associate Professor
  • 2025.04
    -
    Now
    Institute of Science Tokyo， -， Institute of Integrated Research， Center for Brain Integration Research， Associate Professor

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Published Papers & Misc 【 display / non-display 】

  1. Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A Fischer, Kyota Fujita, Amit L Deshmukh, Rachel J Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E Leib, Ran Chen, Hikari Tanaka, Amanda G Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R La Spada, Eric I Campos, Maurice A Curtis, François-Michel Boisvert, Richard L M Faull, Beverly L Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S Wold, Christopher E Pearson. Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability. Cell. 2023.10; ( PubMed, DOI )

  2. Kyota Fujita, Hidenori Homma, Meihua Jin, Yuki Yoshioka, Xiaocen Jin, Yuko Saito, Hikari Tanaka, Hitoshi Okazawa. Mutant α-synuclein propagates via the lymphatic system of the brain in the monomeric state. Cell Rep. 2023.08; 42 (8): 112962. ( PubMed, DOI )

  3. Xiaocen Jin, Hikari Tanaka, Meihua Jin, Kyota Fujita, Hidenori Homma, Maiko Inotsume, Huang Yong, Kenichi Umeda, Noriyuki Kodera, Toshio Ando, Hitoshi Okazawa. PQBP5/NOL10 maintains and anchors the nucleolus under physiological and osmotic stress conditions. Nat Commun. 2023.01; 14 (1): 9. ( PubMed, DOI )

  4. Tanaka H, Okazawa H. PQBP1: The Key to Intellectual Disability, Neurodegenerative Diseases, and Innate Immunity. Int J Mol Sci. 2022.06; 23 (11): 6227. ( PubMed, DOI )

  5. Shiwaku H, Katayama S, Kondo K, Nakano Y, Tanaka H, Yoshioka Y, Fujita K, Tamaki H, Takebayashi H, Terasaki O, Nagase Y, Nagase T, Kubota T, Ishikawa K, Okazawa H, Takahashi H. Autoantibodies against NCAM1 from patients with schizophrenia cause schizophrenia-related behavior and changes in synapses in mice. Cell Rep Med. 2022.04; 3 (4): 100597. ( PubMed, DOI )

  6. Okazawa H, Tanaka H. Molecular Dissection and Therapeutic Application of SCA1 Pathologies Revealed by Comprehensive Approaches. Cerebellum as a CNS Hub. 2021.11; 479-486.

  7. Jin M, Shiwaku H, Tanaka H, Obita T, Ohuchi S, Yoshioka Y, Jin X, Kondo K, Fujita K, Homma H, Nakajima K, Mizuguchi M, Okazawa H. Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation. Nat Commun. 2021.11; 12 (1): 6565. ( PubMed, DOI )

  8. Tanaka H, Kondo K, Fujita K, Homma H, Tagawa K, Jin X, Jin M, Yoshioka Y, Takayama S, Masuda H, Tokuyama R, Nakazaki Y, Saito T, Saido T, Murayama S, Ikura T, Ito N, Yamamori Y, Tomii K, Bianchi ME, Okazawa H. HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer's disease pathology. Commun Biol. 2021.10; 4 (1): 1175. ( PubMed, DOI )

  9. Jin M, Jin X, Homma H, Fujita K, Tanaka H, Murayama S, Akatsu H, Tagawa K, Okazawa H. Prediction and verification of the AD-FTLD common pathomechanism based on dynamic molecular network analysis. Communications biology. 2021.08; 4 (1): 961. ( PubMed, DOI )

  10. Homma H, Tanaka H, Jin M, Jin X, Huang Y, Yoshioka Y, Bertens CJ, Tsumaki K, Kondo K, Shiwaku H, Tagawa K, Akatsu H, Atsuta N, Katsuno M, Furukawa K, Ishiki A, Waragai M, Ohtomo G, Iwata A, Yokota T, Inoue H, Arai H, Sobue G, Sone M, Fujita K, Okazawa H. DNA damage in embryonic neural stem cell determines FTLDs' fate via early-stage neuronal necrosis. Life science alliance. 2021.07; 4 (7): ( PubMed, DOI )

  11. Kondo K, Ikura T, Tanaka H, Fujita K, Takayama S, Yoshioka Y, Tagawa K, Homma H, Liu S, Kawasaki R, Huang Y, Ito N, Tate SI, Okazawa H. Hepta-Histidine Inhibits Tau Aggregation. ACS chemical neuroscience. 2021.07; ( PubMed, DOI )

  12. Tanaka Hikari, Kondo Kanoh, Chen Xigui, Homma Hidenori, Tagawa Kazuhiko, Saido Takaomi, Muramatsu Shin-ichi, Fujita Kyota, Okazawa Hitoshi. 超早期アルツハイマー病においてSRRM2リン酸化はシナプス病理を誘発する(Phosphorylation of SRRM2 leads to synaptic pathology at ultra-early phase of Alzheimer's disease) 臨床神経学. 2020.11; 60 (Suppl.): S345. ( ichushi )

  13. Tanaka Hikari, Homma Hidenori, Fujita Kyota, Kondo Kanoh, Yamada Shingo, Jin Xiaocen, Waragai Masaaki, Ohtomo Gaku, Iwata Atsushi, Tagawa Kazuhiko, Atsuta Naoki, Katsuno Masahisa, Tomita Naoki, Furukawa Katsutoshi, Saito Yuko, Saito Takashi, Ichise Ayaka, Shibata Shinsuke, Arai Hiroyuki, Saido Takaomi, Sudol Marius, Muramatsu Shin-ichi, Okano Hideyuki, Mufson Elliott J., Sobue Gen, Murayama Shigeo, Okazawa Hitoshi. YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology NATURE COMMUNICATIONS. 2020.01; 11 (1): 507. ( PubMed, DOI )

  14. Tanaka Hikari, Kondo Kanoh, Chen Xigui, Homma Hidenori, Tagawa Kazuhiko, Kerever Aurelian, Aoki Shigeki, Saito Takashi, Saido Takaomi, Muramatsu Shin-ichi, Fujita Kyota, Okazawa Hitoshi. The intellectual disability gene PQBP1 rescues Alzheimer's disease pathology MOLECULAR PSYCHIATRY. 2018.10; 23 (10): 2090-2110. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. 田中 ひかり. PQBP5/NOL10 maintains and anchors the nucleolus under physiological and stress conditions. 第46回日本神経科学大会 2023.08.04

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Others 【 display / non-display 】

  • Promising new treatment for a common hereditary nerve disease，2023.12

  • Timing of Brain Cell Death Uncovers a New Target for Alzheimer's Treatment，2020.02

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