Personnel Information

写真a

HATANO Megumi


Job title

Assistant Professor
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Campus Career 【 display / non-display 】

  • 2015.04
    -
    2019.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Advanced Therapeutic Sciences， Molecular Endocrinology and Metabolism， Graduate Student
  • 2019.04
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    2020.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Division of Advanced Therapeutic Sciences， Department of Molecular Oncology， Visiting Lecturer
  • 2020.04
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    2021.04
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Division of Advanced Therapeutic Sciences， Department of Molecular Oncology， Visiting Lecturer
  • 2021.05
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    2022.04
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Division of Advanced Therapeutic Sciences， Department of Molecular Oncology， Visiting Lecturer
  • 2022.05
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    2022.09
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Division of Advanced Therapeutic Sciences， Department of Molecular Oncology， Visiting Lecturer
  • 2022.10
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    2024.09
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Advanced Therapeutic Sciences， Molecular Oncology， Assistant Professor
  • 2024.10
    -
    Now
    Institute of Science Tokyo， -， Graduate Schools， Advanced Therapeutic Sciences， Department of Molecular Oncology， Assistant Professor

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Academic Society Affiliations 【 display / non-display 】

  • Japan Pediatric Society

  • The Japan Endocrine Society

  • The Japan Diabetes Society

  • The Japanese Society for Pediatric Endocrinology

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Qualification Acquired 【 display / non-display 】

  • Doctor

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Published Papers & Misc 【 display / non-display 】

  1. Akihisa Ishikawa,Megumi Hatano,Ikuko Inai,Naoki Umehara,Yosuke Hosoya,Yuko Nagaoki,Miwa Ozawa. Concurrent Histiocytic Necrotizing Lymphadenitis and Painless Thyroiditis in a Child: A Case Report Pediatrics International. 2026.04; 1 (68): ( DOI )

  2. Nara Atsushi, Shimada Shu, Akiyama Yoshimitsu, Hatano Megumi, Chino Yusuke, Miyazawa Suguru, Tamura Hanako, Asano Daisuke, Ishikawa Yoshiya, Ueda Hiroki, Watanabe Shuichi, Katsuta Eriko, Akahoshi Keiichi, Ohashi Kenichi, Tanabe Minoru, Ban Daisuke, Tanaka Shinji. Targeting SPP1-CD44-Hedgehog Axis Elicits Therapeutic Effects in Hepatocellular Carcinoma by Suppressing Intratumoral Fibrosis(タイトル和訳中) Cancer Science. 2026.03; 117 (3): 670-682. ( ichushi )

  3. Hiroki Yoshihara, Saori Aiga, Megumi Hatano, Kyoko Nagase, Michiyo Gunji, Yuri Yoshimoto Suzuki, Yosuke Hosoya,Yasushi Ishida, Kyoko Kobayashi,Atsushi Manabe,Daisuke Hasegawa,Miwa Ozawa. Gonadal Dysfunction in Male Childhood Cancer Survivors: A Report from the St. Luke’s Childhood Cancer Survivors Cohort Study (LUKE Cohort Study) JOURNAL OF ADOLESCENT AND YOUNG ADULT ONCOLOGY. 2026.03; ( DOI )

  4. Masahiro Yamane, Yoshimitsu Akiyama, Shu Shimada, Shuichi Watanabe, Megumi Hatano , Shu Tsukihara , Suguru Miyazawa , Hanako Tamura, Atsushi Nara, Keita Kodera, Kohei Okazaki, Yoshiaki Tanji, Yosuke Igarashi, Atsushi Kamachi, Kentaro Umemura, Koya Yasukawa, Keiichi Akahoshi, Kenichi Ohashi, Daisuke Ban, Shinji Tanaka. H4K5 lactylation - ENO2 loop drives glycolysis and HCC progression JHEP Rep . 2026.03; 5 (8):

  5. Taniai T, Shimada S, Akiyama Y, Hatano M, Yasukawa K, Igarashi Y, Tsukihara S, Tanji Y, Kodera K, Okazaki K, Haruki K, Nara A, Yagi K, Akahoshi K, Ban D, Asahina Y, Ikegami T, Tanabe M, Tanaka S. Integrative transcriptome profiling elucidates molecular and immunovascular characteristics of macrotrabecular HCC. Hepatology (Baltimore, Md.). 2026.02; 83 (2): 231-248. ( PubMed, DOI )

  6. Yoshiaki Tanji, Shu Shimada, Megumi Kato, Yoshimitsu Akiyama , Megumi Hatano, Shu Tsukihara, Yosuke Igarashi, Keita Kodera, Kohei Okazaki, Koya Yasukawa, Kentaro Umemura, Atsushi Kamachi, Atsushi Nara, Masahiro Yamane, Yoshiya Ishikawa, Erika Mochizuki, Yuki Mochida, Toru Ikegami, Daisuke Ban, Satoshi Uchida, Shinji Tanaka. Cytokine mRNA-based therapy alleviates dendritic cell and T cell paucity to eliminate aggressive pancreatic cancer in preclinical mouse models EBioMedicine. 2026.02; (125):

  7. Atsushi Nara, Shu Shimada, Yoshimitsu Akiyama, Megumi Hatano, Yusuke Chino, Suguru Miyazawa, Hanako Tamura, Daisuke Asano, Yoshiya Ishikawa, Hiroki Ueda, Shuichi Watanabe, Eriko Katsuta, Keiichi Akahoshi, Kenichi Ohashi, Minoru Tanabe, Daisuke Ban, Shinji Tanaka. Targeting SPP1-CD44-Hedgehog Axis Elicits Therapeutic Effects in Hepatocellular Carcinoma by Suppressing Intratumoral Fibrosis. Cancer Sci. 2025.12; Online ahead of print. ( PubMed, DOI )

  8. Kentaro Umemura, Yoshimitsu Akiyama, Shu Shimada, Megumi Hatano, Ayumi Kono, Koya Yasukawa, Atsushi Kamachi, Yosuke Igarashi, Shu Tsukihara, Yoshiaki Tanji, Koichiro Morimoto, Atsushi Nara, Masahiro Yamane, Keiichi Akahoshi, Hiroaki Ono, Akira Shimizu, Yuji Soejima, Minoru Tanabe, Daisuke Ban, Shinji Tanaka. PAD2-Mediated Histone Citrullination Drives Tumor Progression by Enhancing Cell Proliferation and Modifying the Microenvironment in Pancreatic Cancer Mol Cancer Res. 2025.10; 10 (23):

  9. Igarashi Y, Akiyama Y, Shimada S, Watanabe S, Hatano M, Kodera K, Okazaki K, Tanji Y, Tsukihara S, Taniai T, Nara A, Yamane M, Kamachi A, Umemura K, Yasukawa K, Ono H, Akahoshi K, Tanabe M, Haruki K, Furukawa K, Ikegami T, Tanaka S. Identification and clinical implications of endogenous retrovirus elements suppressed by SETDB1 in hepatocellular carcinoma. JHEP reports : innovation in hepatology. 2025.03; 7 (3): 101307. ( PubMed, DOI )

  10. Hatano Megumi, Tanase-Nakao Kanako, Uehara Erika, Iwano Reiko, Muroya Koji, Narumi Satoshi. 先天性甲状腺機能低下症の新生児スクリーニングでTHRB遺伝子とDUOX2遺伝子の変異が同時に検出された症例　甲状腺ホルモン不応症の1症例(Concurrent THRB and DUOX2 variants in a patient detected via newborn screening for congenital hypothyroidism: a case of resistance to thyroid hormone) Clinical Pediatric Endocrinology. 2024.03; 33 (2): 94-100. ( ichushi )

  11. Hatano M, Tanase-Nakao K, Uehara E, Iwano R, Muroya K, Narumi S. Concurrent THRB and DUOX2 variants in a patient detected via newborn screening for congenital hypothyroidism: a case of resistance to thyroid hormone. Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology. 2024.02; 33 (2): 94-100. ( PubMed, DOI )

  12. Taniai T, Shimada S, Akiyama Y, Hatano M, Yasukawa K, Igarashi Y, Tsukihara S, Tanji Y, Kodera K, Okazaki K, Haruki K, Nara A, Yagi K, Akahoshi K, Ban D, Asahina Y, Ikegami T, Tanabe M, Tanaka S. . Integrative transcriptome profiling elucidates molecular and immunovascular characteristics of macrotrabecular hepatocellular carcinoma. Hepatology. 2024; in press.

  13. Igarashi Y, Akiyama Y, Shimada S, Watanabe S, Hatano M, Kodera K, Okazaki K, Tanji Y, Tsukihara S, Taniai T, Nara A, Yamane M, Kamachi A, Umemura K, Yasukawa K, Ono H, Akahoshi K, Tanabe M, Haruki K, Furukawa K, Ikegami T, Tanaka S. Identification and clinical implications of endogenous retrovirus elements suppressed by SETDB1 in hepatocellular carcinoma. JHEP Reports. 2024; in press. ( DOI )

  14. Tsukihara S, Akiyama Y, Shimada S, Hatano M, Igarashi Y, Taniai T, Tanji Y, Kodera K, Yasukawa K, Umeura K, Kamachi A, Nara A, Okuno K, Tokunaga M, Katoh H, Ishikawa S, Ikegami T, Kinugasa Y, Eto K, Tanaka S. Delactylase effects of SIRT1 on a positive feedback loop involving the H19-glycolysis-histone lactylation in gastric cancer. Oncogene. 2024; 44 (11): 724- in press. ( PubMed, DOI )

  15. Hatano M, Akiyama Y, Shimada S, Yagi K, Akahoshi K, Itoh M, Tanabe M, Ogawa Y, Tanaka S. Loss of KDM6B epigenetically confers resistance to lipotoxicity in nonalcoholic fatty liver disease-related hepatocellular carcinoma. Hepatology Communications. 2023.10; 7 (10): e0277.

  16. Hatano M, Akiyama Y, Shimada S, Yagi K, Akahoshi K, Itoh M, Tanabe M, Ogawa Y, Tanaka S. Loss of KDM6B epigenetically confers resistance to lipotoxicity in nonalcoholic fatty liver disease-related HCC. Hepatology communications. 2023.10; 7 (10): ( PubMed, DOI )

  17. Tanimoto Eri, Hatano Megumi, Hosoya Yousuke, Yoshimoto Yuri, Hasegawa Daisuke, Manabe Atsushi, Ishida Yasushi, Ozawa Miwa. LATE EFFECTS ON GLUCOSE AND LIPID METABOLISM IN CHILDHOOD CANCER SURVIVORS PEDIATRIC BLOOD & CANCER. 2022.11; 69

  18. Hatano Megumi, Fukuzawa Ryuji, Hasegawa Yukihiro. The Mosaicism Ratio of 45,X May Explain the Phenotype in a Case of Mixed Gonadal Dysgenesis SEXUAL DEVELOPMENT. 2018; 12 (4): 175-179. ( PubMed, DOI )

  19. Hasegawa Yukihiro, Ariyasu Daisuke, Izawa Masako, Igaki-Miyamoto Junko, Fukuma Mami, Hatano Megumi, Yagi Hiroko, Goto Masahiro. Turner症候群におけるエチニルエストラジオールの漸増によって良好な最終身長は得られるが骨密度の獲得にはつながらない(Gradually increasing ethinyl estradiol for Turner syndrome may produce good final height but not ideal BMD) Endocrine Journal. 2017.02; 64 (2): 221-227. ( ichushi )

  20. Hatano M, Migita T, Ohishi T, Shima Y, Ogawa Y, Morohashi KI, Hasegawa Y, Shibasaki F. SF-1 deficiency causes lipid accumulation in Leydig cells via suppression of STAR and CYP11A1. Endocrine. 2016.11; 54 (2): 484-496. ( PubMed, DOI )

  21. Fukuma Mami, Ariyasu Daisuke, Hatano Megumi, Yagi Hiroko, Hasegawa Yukihiro. Wolfram症候群による早期発症泌尿器障害　新生児期に発症した1症例(Early-onset urological disorders due to Wolfram syndrome: A case of neonatal onset) Clinical Pediatric Endocrinology. 2016.04; 25 (2): 67-69. ( ichushi )

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Conference Activities & Talks 【 display / non-display 】

  1. Megumi Hatano, Rintaro Ono, Misato Suzuki, Masayo Kagami, Michiko Yamanaka. A Case of Temple Syndrome Where Atypical NIPT Findings Provided a Diagnostic Clue. The 22nd International Congress of Endocrinology 2026.06.03

  2. 秋山 好光, 月原 秀, 島田 周, 波多野 恵, 絹笠 祐介, 衛藤 謙, 田中 真二. 胃癌におけるSIRT欠失はH19-解糖系-ヒストンラクチル化の正のフィードバックを促進する(Loss of SIRT1 drives a positive feedback loop pathway of H19-glycolysis-histone lactylation in gastric cancer). 日本癌学会総会記事 2025.09.01

  3. Masahiro Yamane,Yoshimitsu Akiyama,Shu Shimada,Suguru Miyazawa,Atsushi Nara,Shu Tsukihara, Shuichi Watanabe,Megumi Hatano,Keiichi Akahoshi,Daisuke Ban,Shinji Tanaka. Mechanism of Lactate Metabolism Regulation and Poor Prognosis in Hepatocellular Carcinoma via Histone Lactylation. The 37th Meeting of Japanese Society of Hapato-Biliary-Pancreatic Surgery 2025.06.14 Karuizawa,Nagano

  4. Yamane Masahiro, Akiyama Yoshimitsu, Shimada Shu, Miyazawa Suguru, Nara Atsushi, Tsukihara Shu, Watanabe Shuichi, Hatano Megumi, Akahoshi Keiichi, Ban Daisuke, Tanaka Shinji. HBP外科分野における最新の橋渡し研究　肝細胞癌におけるヒストンラクチル化を介した乳酸代謝調節の機序と予後不良(Latest Translational Research in the Field of HBP Surgery　Mechanism of Lactate Metabolism Regulation and Poor Prognosis in Hepatocellular Carcinoma via Histone Lactylation). 日本肝胆膵外科学会・学術集会プログラム・抄録集 2025.06.01

  5. Yoshihara Hiroki, Maeda Kunie, Nagase Kyoko, Nakauchi Tomoko, Gunji Michiyo, Hosoya Yosuke, Hatano Megumi, Ozawa Miwa, Manabe Atsushi, Hasegawa Daisuke. 性腺機能低下症を抱える男性小児がんサバイバーの移行期医療(The transition medical care for male childhood cancer survivors with gonadal dysfunction). 日本小児血液・がん学会雑誌 2025.01.01

  6. Shu Tsukihara, Yoshimitsu Akiyama, Shu Shimada, Megumi Hatano, Yusuke Kinugasa, Ken Eto, Shinji Tanaka. Histone H3 lysin 9 methyltransferase SETDB1 promotes gastric carcinogenesis by multiple signaling pathways. Digestive Disease Week 2023 2023.05.10 Chicago

  7. Tanimoto Eri, Hatano Megumi, Hosoya Yousuke, Yoshimoto Yuri, Hasegawa Daisuke, Manabe Atsushi, Ishida Yasushi, Ozawa Miwa. 包括的コホート研究による小児がんサバイバーの糖代謝・生活習慣の長期フォローアップ結果の検討(Late effects on glucose and lipid metabolism in childhood cancer survivors). 日本小児血液・がん学会雑誌 2022.10.01

  8. 右田 敏郎, 上田 彩乃, 大石 智一, 波多野 恵, 堀口 慎一郎, 古賀 文隆, 芝崎 太. 膀胱がんにおける上皮間葉移行を介した幹細胞性の獲得. 日本癌学会総会記事 2015.10.01

  9. Hirose Masakazu, Hashimura Kayako, Hatano Megumi, Kashihara Yoneo, Hashimoto Tomomi, Higashide Takashi, Aono Shigeo, Kawamura Tomoyuki. CGMは糖尿病治療に何をもたらしたか?　夢から実践へ　CGMを用いた糖尿病の新規治療法　後向きCGMからリアルタイムCGMへ(What did CGM bring to diabetes treatment? From dreams to actual practice　New therapy for diabetes using CGM: from Retrospective CGM to Real-time CGM). 糖尿病 2014.04.01

  10. Hatano Megumi, Ishikura Kenji, Sakai Tomoyuki, Hamasaki Yuko, Hataya Hiroshi, Ogata Kentaro, Fukuzawa Ryuji, Honda Masataka. 膜性増殖性糸球体腎炎I型の小児における完全寛解後の再発の繰り返し(Recurrent Relapses after Complete Remission in a Child with Membranoproliferative Glomerulonephritis Type I). 日本小児腎臓病学会雑誌 2011.06.01

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