基本情報

写真a

坂上 史佳(サカウエ フミカ)

Fumika Sakaue


職名

特任助教

取得学位 【 表示 / 非表示

  • 博士(理学)  東京大学

経歴(学内) 【 表示 / 非表示

  • 2014年10月
    -
    2018年03月
    東京医科歯科大学 大学院医歯学総合研究科 医歯学系専攻 認知行動医学講座 脳神経病態学 特任助教
  • 2018年04月
    -
    2019年03月
    東京医科歯科大学 大学院医歯学総合研究科 医歯学系専攻 認知行動医学講座 脳神経病態学 特任助教
  • 2020年10月
    -
    現在
    東京医科歯科大学 大学院医歯学総合研究科 医歯学系専攻 認知行動医学講座 脳神経病態学 特任助教

経歴(学外) 【 表示 / 非表示

  • 広島大学 医系科学研究科 寄付講座 助教
  • イェール大学 医学部 博士研究員
  • 東京大学 分子細胞生物学研究所 博士研究員
  • 東京大学 理学系研究科 生物化学専攻 修了
  • 東京都立大学 理学部 生物学科 卒業

所属学協会 【 表示 / 非表示

  • Society for Neuroscience

  • 日本神経化学会

  • 日本神経科学会

  • 日本核酸医薬学会

研究分野 【 表示 / 非表示

  • 神経科学一般

 

論文・総説 【 表示 / 非表示

  1. Ken Asada, Fumika Sakaue, Tetsuya Nagata, Ji-Chun Zhang, Kie Yoshida-Tanaka, Aya Abe, Makiko Nawa, Kazutaka Nishina, Takanori Yokota. Short DNA/RNA heteroduplex oligonucleotide interacting proteins are key regulators of target gene silencing. Nucleic acids research. 2021.05; 49 (9): 4864-4876. ( PubMed, DOI )

  2. Daisuke Ono, Ken Asada, Daishi Yui, Fumika Sakaue, Kotaro Yoshioka, Tetsuya Nagata, Takanori Yokota. Separation-related rapid nuclear transport of DNA/RNA heteroduplex oligonucleotide: unveiling distinctive intracellular trafficking. Mol Ther Nucleic Acids. 2021.03; 23 1360-1370. ( PubMed, DOI )

  3. Matsuhisa Koji, Cai Longjie, Saito Atsushi, Sakaue Fumika, Kamikawa Yasunao, Fujiwara Sachiko, Asada Rie, Kudo Yukitsuka, Imaizumi Kazunori. Toxic effects of endoplasmic reticulum stress transducer BBF2H7-derived small peptide fragments on neuronal cells. Brain Res. 2020.12; 1749 147139. ( PubMed, DOI )

  4. Okamoto Takumi, Wu Yan, Matsuhisa Koji, Saito Atsushi, Sakaue Fumika, Imaizumi Kazunori, Kaneko Masayuki. Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit. Biochem Biophys Res Commun. 2020.01; 521 (4): 1030-1035. ( PubMed, DOI )

  5. Matsuhisa Koji, Saito Atsushi, Cai Longjie, Kaneko Masayuki, Okamoto Takumi, Sakaue Fumika, Asada Rie, Urano Fumihiko, Yanagida Kanta, Okochi Masayasu, Kudo Yukitsuka, Matsumoto Masaki, Nakayama Keiichi I, Imaizumi Kazunori. Production of BBF2H7-derived small peptide fragments via endoplasmic reticulum stress-dependent regulated intramembrane proteolysis. FASEB J. 2020.01; 34 (1): 865-880. ( PubMed, DOI )

  6. Wu Yan, Kimura Yuka, Okamoto Takumi, Matsuhisa Koji, Asada Rie, Saito Atsushi, Sakaue Fumika, Imaizumi Kazunori, Kaneko Masayuki. Inflammatory bowel disease-associated ubiquitin ligase RNF183 promotes lysosomal degradation of DR5 and TRAIL-induced caspase activation. Sci Rep. 2019.12; 9 (1): 20301. ( PubMed, DOI )

  7. Wilson Rashaun S, Rauniyar Navin, Sakaue Fumika, Lam TuKiet T, Williams Kenneth R, Nairn Angus C. Development of Targeted Mass Spectrometry-Based Approaches for Quantitation of Proteins Enriched in the Postsynaptic Density (PSD). Proteomes. 2019.04; 7 (2): ( PubMed, DOI )

  8. Nakamura Tsutomu, Sakaue Fumika, Nasu-Nishimura Yukiko, Takeda Yasuko, Matsuura Ken, Akiyama Tetsu. The Autism-Related Protein PX-RICS Mediates GABAergic Synaptic Plasticity in Hippocampal Neurons and Emotional Learning in Mice. EBioMedicine. 2018.08; 34 189-200. ( PubMed, DOI )

  9. Iwata Masaaki, Ota Kristie T, Li Xiao-Yuan, Sakaue Fumika, Li Nanxin, Dutheil Sophie, Banasr Mounira, Duric Vanja, Yamanashi Takehiko, Kaneko Koichi, Rasmussen Kurt, Glasebrook Andrew, Koester Anja, Song Dekun, Jones Kenneth A, Zorn Stevin, Smagin Gennady, Duman Ronald S. Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor. Biol Psychiatry. 2016.07; 80 (1): 12-22. ( PubMed, DOI )

  10. Nakamura Tsutomu, Arima-Yoshida Fumiko, Sakaue Fumika, Nasu-Nishimura Yukiko, Takeda Yasuko, Matsuura Ken, Akshoomoff Natacha, Mattson Sarah N, Grossfeld Paul D, Manabe Toshiya, Akiyama Tetsu. PX-RICS-deficient mice mimic autism spectrum disorder in Jacobsen syndrome through impaired GABAA receptor trafficking. Nat Commun. 2016.03; 7 10861. ( PubMed, DOI )

  11. Colangelo Christopher M, Ivosev Gordana, Chung Lisa, Abbott Thomas, Shifman Mark, Sakaue Fumika, Cox David, Kitchen Robert R, Burton Lyle, Tate Stephen A, Gulcicek Erol, Bonner Ron, Rinehart Jesse, Nairn Angus C, Williams Kenneth R. Development of a highly automated and multiplexed targeted proteome pipeline and assay for 112 rat brain synaptic proteins. Proteomics. 2015.04; 15 (7): 1202-1214. ( PubMed, DOI )

  12. Uchida Azusa, Sasaguri Hiroki, Kimura Nobuyuki, Tajiri Mio, Ohkubo Takuya, Ono Fumiko, Sakaue Fumika, Kanai Kazuaki, Hirai Takashi, Sano Tatsuhiko, Shibuya Kazumoto, Kobayashi Masaki, Yamamoto Mariko, Yokota Shigefumi, Kubodera Takayuki, Tomori Masaki, Sakaki Kyohei, Enomoto Mitsuhiro, Hirai Yukihiko, Kumagai Jiro, Yasutomi Yasuhiro, Mochizuki Hideki, Kuwabara Satoshi, Uchihara Toshiki, Mizusawa Hidehiro, Yokota Takanori. Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43. Brain. 2012.03; 135 (Pt 3): 833-846. ( PubMed, DOI )

  13. Nakamura Tsutomu, Hayashi Tomoatsu, Mimori-Kiyosue Yuko, Sakaue Fumika, Matsuura Ken, Iemura Shun-ichiro, Natsume Toru, Akiyama Tetsu. The PX-RICS-14-3-3zeta/theta complex couples N-cadherin-beta-catenin with dynein-dynactin to mediate its export from the endoplasmic reticulum. J Biol Chem. 2010.05; 285 (21): 16145-16154. ( PubMed, DOI )

  14. Nakamura Tsutomu, Hayashi Tomoatsu, Nasu-Nishimura Yukiko, Sakaue Fumika, Morishita Yasuyuki, Okabe Toshio, Ohwada Susumu, Matsuura Ken, Akiyama Tetsu. PX-RICS mediates ER-to-Golgi transport of the N-cadherin/beta-catenin complex. Genes Dev. 2008.05; 22 (9): 1244-1256. ( PubMed, DOI )

  15. Hayashi Tomoatsu, Okabe Toshio, Nasu-Nishimura Yukiko, Sakaue Fumika, Ohwada Susumu, Matsuura Ken, Akiyama Tetsu, Nakamura Tsutomu. PX-RICS, a novel splicing variant of RICS, is a main isoform expressed during neural development. Genes Cells. 2007.08; 12 (8): 929-939. ( PubMed, DOI )

  16. Sasaki Takahiro, Gotow Takahiro, Shiozaki Motoko, Sakaue Fumika, Saito Taro, Julien Jean-Pierre, Uchiyama Yasuo, Hisanaga Shin-Ichi. Aggregate formation and phosphorylation of neurofilament-L Pro22 Charcot-Marie-Tooth disease mutants. Hum Mol Genet. 2006.03; 15 (6): 943-952. ( PubMed, DOI )

  17. Sakaue Fumika, Saito Taro, Sato Yutaka, Asada Akiko, Ishiguro Koichi, Hasegawa Masato, Hisanaga Shin-ichi. Phosphorylation of FTDP-17 mutant tau by cyclin-dependent kinase 5 complexed with p35, p25, or p39. J Biol Chem. 2005.09; 280 (36): 31522-31529. ( PubMed, DOI )

▼全件表示

書籍等出版物 【 表示 / 非表示

  1. 坂上史佳, 横田隆徳. Annual Review 神経2018. 中外医学社, 2018.01 筋萎縮性側索硬化症と異常タンパク質(TDP-43・C9ORF72) (ISBN : 978-4-498-32806-8)

  2. 秋山徹,奥山隆平,河府和義/編. 完全版マウス・ラット疾患モデル活用ハンドブック. 2010.12 (ISBN : 978-4-7581-2017-3)

  3. 高分子学会編. 高分子辞典(第3版). 2005.06 (ISBN : 978-4-254-25248-4)

講演・口頭発表等 【 表示 / 非表示

  1. Fumika Sakaue, Motoki Miura, Taro Ishiguro, Hirokazu Matsuno, Tatsuhiko Sano, Ryo Iwase, Rintaro Hara, Takeshi Wada, Tetsuya Nagata, Takanori Yokota. Chemically modified short oligonucleotide regulates LLPS and reduces TDP-43 pathology in vivo. Pan-Asia Consortium for Treatment and Research in ALS 2021 2021.09.17 Web

  2. Fumika Sakaue. LLPS – A new therapeutic target for neurodegenerative disease. the 44th Annual Meeting of the Japan Neuroscience Society 2021.07.29 Kobe