Personnel Information

写真a

Fumika Sakaue


Job title

Project Junior Associate Professor

Research Areas, Keywords

Neuroscience
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Campus Career 【 display / non-display 】

  • 2014.10
    -
    2018.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Neurology and Neurological Science， Project Assistant Professor
  • 2018.04
    -
    2019.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Neurology and Neurological Science， Project Assistant Professor
  • 2020.10
    -
    2024.06
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Neurology and Neurological Science， Project Assistant Professor
  • 2024.07
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Neurology and Neurological Science， Project Junior Associate Professor
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External Career 【 display / non-display 】

  • Hiroshima University, Graduate School of Biomedical and Health Sciences, Research Associate professor
  • Yale University School of Medicine, Department of Psychiatry, Postdoctoral associate
  • University of Tokyo, Institute of Molecular and Cellular BioSciences, Postdoctoral fellow
  • The University of Tokyo, Department of Biophysics and Biochemistry, Graduate School of Science, Ph.D.
  • Tokyo Metropolitan University, Department of Biological Sciences, School of Science, B.Sc.
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Academic Society Affiliations 【 display / non-display 】

  • The Japan Neuroscience Society

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Research Areas 【 display / non-display 】

  • Neuroscience-general

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Published Papers & Misc 【 display / non-display 】

  1. Hasegawa J, Nagata T, Ihara K, Tanihata J, Ebihara S, Yoshida-Tanaka K, Yanagidaira M, Ohara M, Sasaki A, Nakayama M, Yamamoto S, Ishii T, Iwata-Hara R, Naito M, Miyata K, Sakaue F, Yokota T. Heteroduplex oligonucleotide technology boosts oligonucleotide splice switching activity of morpholino oligomers in a Duchenne muscular dystrophy mouse model. Nature communications. 2024.09; 15 (1): 7530. ( PubMed, DOI )

  2. Miura M, Sakaue F, Matsuno H, Morita K, Yoshida A, Hara RI, Nishimura R, Nishida Y, Yokogawa M, Osawa M, Yokota T. TDP-43 N-terminal domain dimerisation or spatial separation by RNA binding decreases its propensity to aggregate. FEBS letters. 2023.05; 597 (12): 1667-1676. ( PubMed, DOI )

  3. Ken Asada, Fumika Sakaue, Tetsuya Nagata, Ji-Chun Zhang, Kie Yoshida-Tanaka, Aya Abe, Makiko Nawa, Kazutaka Nishina, Takanori Yokota. Short DNA/RNA heteroduplex oligonucleotide interacting proteins are key regulators of target gene silencing. Nucleic acids research. 2021.05; 49 (9): 4864-4876. ( PubMed, DOI )

  4. Daisuke Ono, Ken Asada, Daishi Yui, Fumika Sakaue, Kotaro Yoshioka, Tetsuya Nagata, Takanori Yokota. Separation-related rapid nuclear transport of DNA/RNA heteroduplex oligonucleotide: unveiling distinctive intracellular trafficking. Mol Ther Nucleic Acids. 2021.03; 23 1360-1370. ( PubMed, DOI )

  5. Matsuhisa Koji, Cai Longjie, Saito Atsushi, Sakaue Fumika, Kamikawa Yasunao, Fujiwara Sachiko, Asada Rie, Kudo Yukitsuka, Imaizumi Kazunori. Toxic effects of endoplasmic reticulum stress transducer BBF2H7-derived small peptide fragments on neuronal cells. Brain Res. 2020.12; 1749 147139. ( PubMed, DOI )

  6. Okamoto Takumi, Wu Yan, Matsuhisa Koji, Saito Atsushi, Sakaue Fumika, Imaizumi Kazunori, Kaneko Masayuki. Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit. Biochem Biophys Res Commun. 2020.01; 521 (4): 1030-1035. ( PubMed, DOI )

  7. Matsuhisa Koji, Saito Atsushi, Cai Longjie, Kaneko Masayuki, Okamoto Takumi, Sakaue Fumika, Asada Rie, Urano Fumihiko, Yanagida Kanta, Okochi Masayasu, Kudo Yukitsuka, Matsumoto Masaki, Nakayama Keiichi I, Imaizumi Kazunori. Production of BBF2H7-derived small peptide fragments via endoplasmic reticulum stress-dependent regulated intramembrane proteolysis. FASEB J. 2020.01; 34 (1): 865-880. ( PubMed, DOI )

  8. Wu Yan, Kimura Yuka, Okamoto Takumi, Matsuhisa Koji, Asada Rie, Saito Atsushi, Sakaue Fumika, Imaizumi Kazunori, Kaneko Masayuki. Inflammatory bowel disease-associated ubiquitin ligase RNF183 promotes lysosomal degradation of DR5 and TRAIL-induced caspase activation. Sci Rep. 2019.12; 9 (1): 20301. ( PubMed, DOI )

  9. Wilson Rashaun S, Rauniyar Navin, Sakaue Fumika, Lam TuKiet T, Williams Kenneth R, Nairn Angus C. Development of Targeted Mass Spectrometry-Based Approaches for Quantitation of Proteins Enriched in the Postsynaptic Density (PSD). Proteomes. 2019.04; 7 (2): ( PubMed, DOI )

  10. Nakamura Tsutomu, Sakaue Fumika, Nasu-Nishimura Yukiko, Takeda Yasuko, Matsuura Ken, Akiyama Tetsu. The Autism-Related Protein PX-RICS Mediates GABAergic Synaptic Plasticity in Hippocampal Neurons and Emotional Learning in Mice. EBioMedicine. 2018.08; 34 189-200. ( PubMed, DOI )

  11. Iwata Masaaki, Ota Kristie T, Li Xiao-Yuan, Sakaue Fumika, Li Nanxin, Dutheil Sophie, Banasr Mounira, Duric Vanja, Yamanashi Takehiko, Kaneko Koichi, Rasmussen Kurt, Glasebrook Andrew, Koester Anja, Song Dekun, Jones Kenneth A, Zorn Stevin, Smagin Gennady, Duman Ronald S. Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor. Biol Psychiatry. 2016.07; 80 (1): 12-22. ( PubMed, DOI )

  12. Nakamura Tsutomu, Arima-Yoshida Fumiko, Sakaue Fumika, Nasu-Nishimura Yukiko, Takeda Yasuko, Matsuura Ken, Akshoomoff Natacha, Mattson Sarah N, Grossfeld Paul D, Manabe Toshiya, Akiyama Tetsu. PX-RICS-deficient mice mimic autism spectrum disorder in Jacobsen syndrome through impaired GABAA receptor trafficking. Nat Commun. 2016.03; 7 10861. ( PubMed, DOI )

  13. Colangelo Christopher M, Ivosev Gordana, Chung Lisa, Abbott Thomas, Shifman Mark, Sakaue Fumika, Cox David, Kitchen Robert R, Burton Lyle, Tate Stephen A, Gulcicek Erol, Bonner Ron, Rinehart Jesse, Nairn Angus C, Williams Kenneth R. Development of a highly automated and multiplexed targeted proteome pipeline and assay for 112 rat brain synaptic proteins. Proteomics. 2015.04; 15 (7): 1202-1214. ( PubMed, DOI )

  14. Uchida Azusa, Sasaguri Hiroki, Kimura Nobuyuki, Tajiri Mio, Ohkubo Takuya, Ono Fumiko, Sakaue Fumika, Kanai Kazuaki, Hirai Takashi, Sano Tatsuhiko, Shibuya Kazumoto, Kobayashi Masaki, Yamamoto Mariko, Yokota Shigefumi, Kubodera Takayuki, Tomori Masaki, Sakaki Kyohei, Enomoto Mitsuhiro, Hirai Yukihiko, Kumagai Jiro, Yasutomi Yasuhiro, Mochizuki Hideki, Kuwabara Satoshi, Uchihara Toshiki, Mizusawa Hidehiro, Yokota Takanori. Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43. Brain. 2012.03; 135 (Pt 3): 833-846. ( PubMed, DOI )

  15. Nakamura Tsutomu, Hayashi Tomoatsu, Mimori-Kiyosue Yuko, Sakaue Fumika, Matsuura Ken, Iemura Shun-ichiro, Natsume Toru, Akiyama Tetsu. The PX-RICS-14-3-3zeta/theta complex couples N-cadherin-beta-catenin with dynein-dynactin to mediate its export from the endoplasmic reticulum. J Biol Chem. 2010.05; 285 (21): 16145-16154. ( PubMed, DOI )

  16. Nakamura Tsutomu, Hayashi Tomoatsu, Nasu-Nishimura Yukiko, Sakaue Fumika, Morishita Yasuyuki, Okabe Toshio, Ohwada Susumu, Matsuura Ken, Akiyama Tetsu. PX-RICS mediates ER-to-Golgi transport of the N-cadherin/beta-catenin complex. Genes Dev. 2008.05; 22 (9): 1244-1256. ( PubMed, DOI )

  17. Hayashi Tomoatsu, Okabe Toshio, Nasu-Nishimura Yukiko, Sakaue Fumika, Ohwada Susumu, Matsuura Ken, Akiyama Tetsu, Nakamura Tsutomu. PX-RICS, a novel splicing variant of RICS, is a main isoform expressed during neural development. Genes Cells. 2007.08; 12 (8): 929-939. ( PubMed, DOI )

  18. Sasaki Takahiro, Gotow Takahiro, Shiozaki Motoko, Sakaue Fumika, Saito Taro, Julien Jean-Pierre, Uchiyama Yasuo, Hisanaga Shin-Ichi. Aggregate formation and phosphorylation of neurofilament-L Pro22 Charcot-Marie-Tooth disease mutants. Hum Mol Genet. 2006.03; 15 (6): 943-952. ( PubMed, DOI )

  19. Sakaue Fumika, Saito Taro, Sato Yutaka, Asada Akiko, Ishiguro Koichi, Hasegawa Masato, Hisanaga Shin-ichi. Phosphorylation of FTDP-17 mutant tau by cyclin-dependent kinase 5 complexed with p35, p25, or p39. J Biol Chem. 2005.09; 280 (36): 31522-31529. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Nobuaki Kuroiwa, Fumika Sakaue, Motoki Miura, Hirokazu Matsuno, Tetsuya Nagata, Takanori Yokota. Development of intracellular aptamer targeting ALS-associated RNA binding protein FUS. Neuro2024 2024.07.24 Fukuoka

  2. Fumika Sakaue, Motoki Miura, Taro Ishiguro, Hirokazu Matsuno, Tatsuhiko Sano, Ryo Iwase, Rintaro Hara, Takeshi Wada, Tetsuya Nagata, Takanori Yokota. Chemically modified short oligonucleotide regulates LLPS and reduces TDP-43 pathology in vivo. Pan-Asia Consortium for Treatment and Research in ALS 2021 2021.09.17 Web

  3. Fumika Sakaue. LLPS – A new therapeutic target for neurodegenerative disease. the 44th Annual Meeting of the Japan Neuroscience Society 2021.07.29 Kobe

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