Personnel Information

写真a

WATABE TETSURO


Job title

Professor

Homepage URL

http://cellular-biochemistry-tmdu.net/en/

Research Areas, Keywords

cancer, angiogenesis, lymphangiogenesis, TGF-β

Field Introduction URL

Department of Biochemistry

　

β-AR Agonist Therapy Puts the Brakes on Oral Cancer Progression

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Campus Career 【 display / non-display 】

  • 2015.07
    -
    2018.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Matrix， Biochemistry， Professor
  • 2018.04
    -
    2021.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Matrix， Biochemistry， Professor
  • 2021.04
    -
    2022.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， -， Department of Biochemistry， Professor
  • 2022.04
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， -， Department of Biochemistry， Professor
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Academic Activity 【 display / non-display 】

  • 2018.10
    　
    　
    Organizing Committee
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Published Papers & Misc 【 display / non-display 】

  1. Miho Kobayashi, Kashio Fujiwara, Kazuki Takahashi, Yusuke Yoshioka, Takahiro Ochiya, Katarzyna A Podyma-Inoue, Tetsuro Watabe. Transforming growth factor-β-induced secretion of extracellular vesicles from oral cancer cells evokes endothelial barrier instability via endothelial-mesenchymal transition. Inflamm Regen. 2022.09; 42 (1): 38. ( PubMed, DOI )

  2. Kei Takahashi, Ko Abe, Shimpei I Kubota, Noriaki Fukatsu, Yasuyuki Morishita, Yasuhiro Yoshimatsu, Satoshi Hirakawa, Yoshiaki Kubota, Tetsuro Watabe, Shogo Ehata, Hiroki R Ueda, Teppei Shimamura, Kohei Miyazono. An analysis modality for vascular structures combining tissue-clearing technology and topological data analysis. Nat Commun. 2022.09; 13 (1): 5239. ( PubMed, DOI )

  3. Kazuki Takahashi, Katarzyna A. Podyma-Inoue, Maki Saito, Shintaro Sakakitan, Akinari Sugauchi, Keita Iida, Sadahiro Iwabuchi, Daizo Koinuma, Kyoko Kurioka, Toru Konishi, Susumu Tanaka, Atsushi Kaida, Masahiko Miura, Shinichi Hashimoto, Mariko Okada, Toshihiro Uchihashi, Kohei Miyazono, Tetsuro Watabe. TGF-β generates a population of cancer cells residing in G1 phase with high motility and metastatic potential via KRTAP2-3 Cell Reports. 2022.09; 40 111411. ( DOI )

  4. Yuta Ikami, Kazue Terasawa, Tetsuro Watabe, Shigeyuki Yokoyama, Miki Hara-Yokoyama. The two-domain architecture of LAMP2A within the lysosomal lumen regulates its interaction with HSPA8/Hsc70 Autophagy Reports. 2022.05; 1 (1): 205-209. ( DOI )

  5. Kanako Nakayama, Taku Nishijo, Masaaki Miyazawa, Tetsuro Watabe, Miyuki Azuma, Hitoshi Sakaguchi. Hapten sensitization to vaginal mucosa induces less recruitment of dendritic cells accompanying TGF-β-expressing CD206 + cells compared with skin. Immunity, Inflammation and Disease. 2022.04; 10 (4): e605. ( PubMed, DOI )

  6. Yasuhiro Yoshimatsu, Tetsuro Watabe. Emerging roles of inflammation-mediated endothelial-mesenchymal transition in health and disease. Inflammation and Regeneration. 2022.02; 42 (1): 9. ( PubMed, DOI )

  7. Toshihiro Inubushi, Ayaka Fujiwara, Takumi Hirose, Gozo Aoyama, Toshihiro Uchihashi, Naoki Yoshida, Yuki Shiraishi, Yu Usami, Hiroshi Kurosaka, Satoru Toyosawa, Susumu Tanaka, Tetsuro Watabe, Mikihiko Kogo, Takashi Yamashiro. Ras signaling and RREB1 are required for the dissociation of medial edge epithelial cells in murine palatogenesis. Disease Models & Mechanisms. 2022.02; 15 (2): ( PubMed, DOI )

  8. Yuta Ikami, Kazue Terasawa, Kensaku Sakamoto, Kazumasa Ohtake, Hiroyuki Harada, Tetsuro Watabe, Shigeyuki Yokoyama, Miki Hara-Yokoyama. The two-domain architecture of LAMP2A regulates its interaction with Hsc70. Experimental Cell Research. 2022.02; 411 (1): 112986. ( PubMed, DOI )

  9. Yoshiya Asano, Daisuke Okano, Michiya Matsusaki, Tetsuro Watabe, Yasuhiro Yoshimatsu, Mitsuru Akashi, Hiroshi Shimoda. Construction of transplantable artificial vascular tissue based on adipose tissue-derived mesenchymal stromal cells by a cell coating and cryopreservation technique. Scientific Reports. 2021.09; 11 (1): 17989. ( PubMed, DOI )

  10. Shingo Kodama, Katarzyna Α. Podyma‑Inoue, Toshihiro Uchihashi, Kyoko Kurioka, Hitomi Takahashi, Akinari Sugauchi, Kazuki Takahashi, Toshihiro Inubushi, Mikihiko Kogo, Susumu Tanaka, Tetsuro Watabe. Progression of melanoma is suppressed by targeting all transforming growth factor‑β isoforms with an Fc chimeric receptor Oncology Reports. 2021.07; 46 (3): 197. ( DOI )

  11. Nishino K, Yoshimatsu Y, Muramatsu T, Sekimoto Y, Mitani K, Kobayashi E, Okamoto S, Ebana H, Okada Y, Kurihara M, Suzuki K, Inazawa J, Takahashi K, Watabe T, Seyama K. Isolation and characterisation of lymphatic endothelial cells from lung tissues affected by lymphangioleiomyomatosis. Scientific reports. 2021.04; 11 (1): 8406. ( PubMed, DOI )

  12. Terasawa K, Kato Y, Ikami Y, Sakamoto K, Ohtake K, Kusano S, Tomabechi Y, Kukimoto-Niino M, Shirouzu M, Guan JL, Kobayashi T, Iwata T, Watabe T, Yokoyama S, Hara-Yokoyama M. Direct homophilic interaction of LAMP2A with the two-domain architecture revealed by site-directed photo-crosslinks and steric hindrances in mammalian cells. Autophagy. 2021.04; 1-19. ( PubMed, DOI )

  13. Fujimoto M, Kamiyama M, Fuse K, Ryuno H, Odawara T, Furukawa N, Yoshimatsu Y, Watabe T, Prchal-Murphy M, Sexl V, Tahara H, Hayakawa Y, Sato T, Takeda K, Naguro I, Ichijo H. ASK1 suppresses NK cell-mediated intravascular tumor cell clearance in lung metastasis. Cancer science. 2021.04; 112 (4): 1633-1643. ( PubMed, DOI )

  14. Kobayashi M, Wakabayashi I, Suzuki Y, Fujiwara K, Nakayama M, Watabe T, Sato Y. Tubulin carboxypeptidase activity of vasohibin-1 inhibits angiogenesis by interfering with endocytosis and trafficking of pro-angiogenic factor receptors. Angiogenesis. 2021.02; 24 (1): 159-176. ( PubMed, DOI )

  15. Iwasaki K, Akazawa K, Nagata M, Komaki M, Peng Y, Umeda M, Watabe T, Morita I. Angiogenic Effects of Secreted Factors from Periodontal Ligament Stem Cells. Dentistry journal. 2021.01; 9 (1): ( PubMed, DOI )

  16. Sakakitani S, Podyma-Inoue KA, Takayama R, Takahashi K, Ishigami-Yuasa M, Kagechika H, Harada H, Watabe T. Activation of β2-adrenergic receptor signals suppresses mesenchymal phenotypes of oral squamous cell carcinoma cells. Cancer Science. 2020.10; ( PubMed, DOI )

  17. 榊谷 振太郎, 井上 カタジナアンナ, 高橋 和樹, 原田 浩之, 渡部 徹郎. β2-アドレナリン受容体シグナルは口腔扁平上皮癌の進行を阻害する 日本癌学会総会記事. 2020.10; 79回 OJ10-2. ( ichushi )

  18. Takahashi K, Akatsu Y, Podyma-Inoue KA, Matsumoto T, Takahashi H, Yoshimatsu Y, Koinuma D, Shirouzu M, Miyazono K, Watabe T. Targeting all transforming growth factor-β isoforms with an Fc chimeric receptor impairs tumor growth and angiogenesis of oral squamous cell cancer. The Journal of Biological Chemistry. 2020.07; 295 (36): 12559-12572. ( PubMed, DOI )

  19. Yoshimatsu Y, Wakabayashi I, Kimuro S, Takahashi N, Takahashi K, Kobayashi M, Maishi N, Podyma-Inoue KA, Hida K, Miyazono K, Watabe T. TNF-α enhances TGF-β-induced endothelial-to-mesenchymal transition via TGF-β signal augmentation. Cancer Science. 2020.07; 111 (7): 2385-2399. ( PubMed, DOI )

  20. Ojima C, Noguchi Y, Miyamoto T, Saito Y, Orihashi H, Yoshimatsu Y, Watabe T, Takayama K, Hayashi Y, Itoh F. Peptide-2 from mouse myostatin precursor protein alleviates muscle wasting in cancer-associated cachexia. Cancer science. 2020.06; 111 (8): 2954-2964. ( PubMed, DOI )

  21. Yoshimatsu Y, Kimuro S, Pauty J, Takagaki K, Nomiyama S, Inagawa A, Maeda K, Podyma-Inoue KA, Kajiya K, Matsunaga YT, Watabe T. TGF-beta and TNF-alpha cooperatively induce mesenchymal transition of lymphatic endothelial cells via activation of Activin signals. PloS One. 2020.05; 15 (5): e0232356. ( PubMed, DOI )

  22. Yang W, Podyma-Inoue KA, Yonemitsu I, Watari I, Ikeda Y, Guo X, Watabe T, Ono T. Mechanoresponsive and lubricating changes of mandibular condylar cartilage associated with mandibular lateral shift and recovery in the growing rat. Clinical oral investigations. 2020.02; 24 (10): 3547-3557. ( PubMed, DOI )

  23. Yuji Kato, Satoko Arakawa, Kazue Terasawa, Jin-Ichi Inokuchi, Takanori Iwata, Shigeomi Shimizu, Tetsuro Watabe, Miki Hara-Yokoyama. The ceramide analogue N-(1-hydroxy-3-morpholino-1-phenylpropan-2-yl)decanamide induces large lipid droplet accumulation and highlights the effect of LAMP-2 deficiency on lipid droplet degradation. Bioorganic & Medicinal Chemistry Letters . 2020.02; 30 (3): 126891. ( PubMed, DOI )

  24. Daisuke Yamamoto, Kou Kayamori, Kei Sakamoto, Maiko Tsuchiya, Tohru Ikeda, Hiroyuki Harada, Tetsuya Yoda, Tetsuro Watabe, Miki Hara-Yokoyama. Intracellular claudin-1 at the invasive front of tongue squamous cell carcinoma is associated with lymph node metastasis. Cancer Science. 2020.02; 111 (2): 700-712. ( PubMed, DOI )

  25. Iwasaki K, Komaki M, Akazawa K, Nagata M, Yokoyama N, Watabe T, Morita I. Spontaneous differentiation of periodontal ligament stem cells into myofibroblast during ex vivo expansion. Journal of cellular physiology. 2019.11; 234 (11): 20377-20391. ( PubMed, DOI )

  26. 高橋 和樹, 井上 カタジナアンナ, 戒田 篤志, 高橋 恵生, 久保田 晋平, 須河内 昭成, 内橋 俊大, 田中 晋, 古郷 幹彦, 三浦 雅彦, 宮園 浩平, 渡部 徹郎. TGF-βにより細胞周期が停止した口腔扁平上皮がん細胞の運動能ならびに転移能は亢進する(TGF-β-induced cell cycle arrest is associated with increased migration and metastasis of oral squamous carcinoma cells) 日本癌学会総会記事. 2019.09; 78回 J-3010. ( ichushi )

  27. Akatsu Y, Takahashi N, Yoshimatsu Y, Kimuro S, Muramatsu T, Katsura A, Maishi N, Suzuki HI, Inazawa J, Hida K, Miyazono K, Watabe T. Fibroblast growth factor signals regulate transforming growth factor-β-induced endothelial-to-myofibroblast transition of tumor endothelial cells via Elk1. Mol. Oncol.. 2019.08; 13 (8): 1706-1724. ( PubMed, DOI )

  28. Iwasaki K, Nagata M, Akazawa K, Watabe T, Morita I. Changes in characteristics of periodontal ligament stem cells in spheroid culture. Journal of periodontal research. 2019.08; 54 (4): 364-373. ( PubMed, DOI )

  29. Ren E, Watari I, Jui-Chin H, Mizumachi-Kubono M, Podyma-Inoue KA, Narukawa M, Misaka T, Watabe T, Ono T. Unilateral nasal obstruction alters sweet taste preference and sweet taste receptors in rat circumvallate papillae. Acta histochemica. 2019.02; 121 (2): 135-142. ( PubMed, DOI )

  30. Okamoto H, Yoshimatsu Y, Tomizawa T, Kunita A, Takayama R, Morikawa T, Komura D, Takahashi K, Oshima T, Sato M, Komai M, Podyma-Inoue KA, Uchida H, Hamada H, Fujiu K, Ishikawa S, Fukayama M, Fukuhara T, Watabe T. Interleukin-13 receptor α2 is a novel marker and potential therapeutic target for human melanoma. Sci Rep. 2019.02; 9 (1): 1281. ( PubMed, DOI )

  31. Iwasaki K, Akazawa K, Nagata M, Komaki M, Honda I, Morioka C, Yokoyama N, Ayame H, Yamaki K, Tanaka Y, Kimura T, Kishida A, Watabe T, Morita I. The Fate of Transplanted Periodontal Ligament Stem Cells in Surgically Created Periodontal Defects in Rats. International journal of molecular sciences. 2019.01; 20 (1): ( PubMed, DOI )

  32. Kazuki Takahashi, Katarzyna A. Podyma-Inoue, Chihiro Takao, Yasuhiro Yoshimatsu Y, Tomoki Muramatsu, Johji Inazawa and Tetsuro Watabe. Regulatory role of transforming growth factor-β signals in the migration and tumor formation of HOC313-LM cells, an oral squamous cell carcinoma 口腔病学会雑誌. 2018.07; 85 (2): 52-61.

  33. 井上 カタジナ・アンナ, 高橋 和樹, 松田 匠源, 吉松 康裕, 横山 三紀, 渡部 徹郎. TGF-β誘発性上皮間葉転換中の口腔扁平上皮癌細胞が分泌するエキソソーム(Exosomes secreted by oral squamous carcinoma cells undergoing TGF-β-induced epithelial to mesenchymal transition) 生命科学系学会合同年次大会. 2017.12; 2017年度 [1P-0028]. ( ichushi )

  34. Takeshi Fukuhara, Jia Kim, Shintaro Hokaiwado, Makiko Nawa, Hayato Okamoto, Tomohiko Kogiso, Tetsuro Watabe, Nobutaka Hattori. A novel immunotoxin reveals a new role for CD321 in endothelial cells. PLoS ONE. 2017.09; 12 (10): e0181502. ( PubMed, DOI )

  35. Yuichi Akatsu, Yasuhiro Yoshimatsu, Taishi Tomizawa, Kazuki Takahashi, Akihiro Katsura, Kohei Miyazono, Tetsuro Watabe. Dual targeting of vascular endothelial growth factor and bone morphogenetic protein-9/10 impairs tumor growth through inhibition of angiogenesis. Cancer Sci.. 2017.01; 108 (1): 151-155. ( PubMed, DOI )

  36. Rie Norita, Yasuhiro Suzuki, Yutaka Furutani, Kazuki Takahashi, Yasuhiro Yoshimatsu, Katarzyna A Podyma-Inoue, Tetsuro Watabe, Yasufumi Sato. Vasohibin-2 is required for epithelial-mesenchymal transition of ovarian cancer cells by modulating TGF-β signaling. Cancer Sci.. 2017.01; ( PubMed, DOI )

  37. Takashi Ode, Katarzyna A Podyma-Inoue, Kazue Terasawa, Jin-Ichi Inokuchi, Toshihide Kobayashi, Tetsuro Watabe, Yuichi Izumi, Miki Hara-Yokoyama. PDMP, a ceramide analogue, acts as an inhibitor of mTORC1 by inducing its translocation from lysosome to endoplasmic reticulum. Exp. Cell Res.. 2017.01; 350 (1): 103-114. ( PubMed, DOI )

  38. Kazue Terasawa, Yuri Tomabechi, Mariko Ikeda, Haruhiko Ehara, Mutsuko Kukimoto-Niino, Motoaki Wakiyama, Katarzyna A Podyma-Inoue, Anupama R Rajapakshe, Tetsuro Watabe, Mikako Shirouzu, Miki Hara-Yokoyama. Lysosome-associated membrane proteins-1 and -2 (LAMP-1 and LAMP-2) assemble via distinct modes. Biochem. Biophys. Res. Commun.. 2016.10; 479 (3): 489-495. ( PubMed, DOI )

  39. Kyohei Muguruma, Fumika Yakushiji, Ryosuke Kawamata, Daichi Akiyama, Risako Arima, Takuya Shirasaka, Yamato Kikkawa, Akihiro Taguchi, Kentaro Takayama, Takeshi Fukuhara, Tetsuro Watabe, Yuji Ito, Yoshio Hayashi. Novel Hybrid Compound of a Plinabulin Prodrug with an IgG Binding Peptide for Generating a Tumor Selective Noncovalent-Type Antibody-Drug Conjugate. Bioconjug. Chem.. 2016.07; 27 (7): 1606-1613. ( PubMed, DOI )

  40. Takenobu Katagiri, Tetsuro Watabe. Bone Morphogenetic Proteins. Cold Spring Harb Perspect Biol. 2016.06; 8 (6): ( PubMed, DOI )

  41. Yasuhiro Yoshimatsu, Hideki Miyazaki, Tetsuro Watabe. Roles of signaling and transcriptional networks in pathological lymphangiogenesis. Adv. Drug Deliv. Rev.. 2016.04; 99 (Pt B): 161-171. ( PubMed, DOI )

  42. Fusa Ogata, Katsuhito Fujiu, Sahohime Matsumoto, Yukiteru Nakayama, Munehiko Shibata, Yuichi Oike, Isao Koshima, Tetsuro Watabe, Ryozo Nagai, Ichiro Manabe. Excess Lymphangiogenesis Cooperatively Induced by Macrophages and CD4(+) T Cells Drives the Pathogenesis of Lymphedema. J. Invest. Dermatol.. 2016.03; 136 (3): 706-714. ( PubMed, DOI )

  43. Akihiro Katsura, Hiroshi I Suzuki, Toshihide Ueno, Hajime Mihira, Tomoko Yamazaki, Takahiko Yasuda, Tetsuro Watabe, Hiroyuki Mano, Yoshitsugu Yamada, Kohei Miyazono. MicroRNA-31 is a positive modulator of endothelial-mesenchymal transition and associated secretory phenotype induced by TGF-β. Genes Cells. 2016.01; 21 (1): 99-116. ( PubMed, DOI )

  44. Masato Morikawa, Daizo Koinuma, Anna Mizutani, Natsumi Kawasaki, Katarina Holmborn, Anders Sundqvist, Shuichi Tsutsumi, Tetsuro Watabe, Hiroyuki Aburatani, Carl-Henrik Heldin, Kohei Miyazono. BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Krüppel-like Factors. Stem Cell Reports. 2016.01; 6 (1): 64-73. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. 小林 美穂, 藤原 花汐, 鈴木 康弘, 若林 育海, 中山 雅敬, 佐藤 靖史, 渡部 徹郎. 微小管の翻訳後修飾による細胞内輸送調節を介したシグナル伝達制御機構とその役割. 第74回日本細胞生物学会大会 2022.06.30 東京

  2. Katarzyna A. Inoue, Kazuki Takahashi, Maki Saito, Shintaro Sakakitani, Toru Konishi, Daizo Koinuma, Akinari Sugauchi, Atsushi Kaida, Yasuhiro Yoshimatsu, Toshihiro Uchihashi, Masahiko Miura, Kohei Miyazono, Tetsuro Watabe. TGF-β-induced cell cycle arrest is correlated with increased migration and metastasis of oral squamous cell carcinoma. 第46回日本リンパ学会総会 2022.06.04 東京都

  3. 小林 美穂. 口腔がん細胞が放出するエクソソームによる血管不安定化機構. 第7回 日本血管生物医学会若手研究会 2022.03.05 淡路島（オンライン ハイブリッド）

  4. Tetsuro Watabe. Roles of signaling and transcriptional networks during maintenance of vascular systems. 第44回日本分子生物学会 2021.12.02 Yokohama

  5. Tetsuro Watabe. Roles of TGF-β family signals during progression of oral cancer.. 13th BMP Conference 2021.11.06 オンライン

  6. Yasuhiro Yoshimatsu, Kentaro Maeda, Naoya Takahashi, Ikumi Wakabayashi, Shiori Kimuro, Kazuki Takahashi, Miho Kobayashi, Katarzyna A. Inoue, Masanori Hirashima, Kohei Miyazono, Tetsuro Watabe . Role of an ETS family transcription factor in endothelial mesenchymal transition (EndoMT)-driven EMT. 第80回日本癌学会学術総会 2021.10.01

  7. Katarzyna A. Inoue, Kazuki Takahashi, Sakakitani Shintaro, Daizo Koinuma, Akinari Sugauchi, Maki Saito, Atsushi Kaida, Yasuhiro Yoshimatsu, Toshihiro Uchihashi, Masahiko Miura, Kohei Miyazono, Tetsuro Watabe. Activation of epithelial-mesenchymal transition program in oral cancer cells under TGF-β-induced cell cycle arrest. TGF-β Superfamily Conference: Signaling in Development and Disease (FASEB) 2021.07.20

  8. Miho Kobayashi、Kashio Fujiwara、Ikumi Wakabayashi、Yasuhiro Suzuki、Masanori Nakayama、Yasufumi Sato、Tetsuro Watabe. Novel anti-angiogenic mechanism of VASH1 through the modification of microtubules. CVMW2020心血管代謝週間（第28回日本血管生物医学会学術集会） 2021.03.12 Web

  9. Miho KOBAYASHI, Ikumi Wakabayashi, Yasuhiro Suzuki, Kashio Fujiwara, Masanori Nakayama, Yasufumi Sato, Tetsuro Watabe. Vasohibin-1 induced post-translational modification of microtubules mediates VEGF-signaling in angiogenesis. 第42回日本分子生物学会年会（MBSJ2020） 2020.12.03 WEB

  10. Katarzyna A. Inoue, Shintaro Sakakitani, Kazuki Takahashi, Hiroyuki Harada, Tetsuro Watabe. Novel approach for treatment of oral squamous cell carcinoma. 第79回日本癌学会学術総会 2020.10.03 広島

  11. Kazuki Takahashi, Katarzyna A. Inoue, Atsushi Kaida, Akinari Sugauchi, Toshihiro Uchihashi, Yasuhiro Yoshimatsu, Susumu Tanaka, Masahiko Miura, Mikihiko Kogo, Tetsuro Watabe. TGF-β-induced cell cycle arrest is associated with increased migration and metastasis of oral squamous carcinoma cells. 第79回日本癌学会学術総会 2020.10 広島

  12. Yasuhiro Yoshimatsu, Ikumi Wakabayashi, Shiori Kimuro, Naoya Takahashi, Kazuki Takahashi, Miho Kobayashi, Katarzyna A. Inoue, Kohei Miyazono, Tetsuro Watabe. Endothelial-derived TGF-β signals activated during ednothelial-to-mesenchymal transition induce EMT of oral cancer cells. 第79回日本癌学会学術総会 2020.10

  13. Katarzyna A. Inoue, Kazuki Takahashi, Maki Saito, Atsushi Kaida, Akinari Sugauchi, Toshihiro Uchihashi, Yasuhiro Yoshimatsu, Susumu Tanaka, Masahiko Miura, Mikihiko Kogo, Tetsuro Watabe. Oral squamous carcinoma cells under TGF-β-induced cell cycle arrest represent highly motile and invasive population. AACR Virtual Special Conference: Tumor Heterogeneity: From Single Cells to Clinical Impact 2020.09.17

  14. Tetsuro Watabe. Roles of TGF-β family signals during formation and maintenance of blood and lymphatic vascular systems.. International Vascular Biology Meeting 2020 2020.09.11 Seoul, Korea

  15. Miho Kobayashi,Ikumi Wakabayashi,Yasuhiro Suzuki,Yasufumi Sato,Tetsuro Watabe. Vasohibin-1 Inhibits Angiogenesis via the Increase of Detyrosinated α-Tubulin. The 21st International Vascular Biology Meeting (IVBM2020) 2020.09.09 Korea (WEB hybrid)

  16. Katarzyna Inoue, Rina Takayama, Kazuki Takahashi, Tetsuro Watabe. Characterization of exosomes secreted from oral squamous carcinoma cells during epithelial to mesenchymal transition. Proteoglycans 2019 2019.10.01 Kanazawa, Japan

  17. Tetsuro Watabe. Roles of TGF-β family signals during the formation and maintenance of vascular systems.. Joint Vascular Biology Meeting 2019.09.20 Sydney,Australia

  18. Tetsuro Watabe. TGF-β-induced cell cycle arrest is associated with increased migration and metastasis of oral squamous carcinoma cells.. TGF-β Signaling Meeting 2019.08.24 Leiden,The Netherlands

  19. 濵 洋平，水口俊介，佐々木啓一，前田健康，羽村　章，一戸達也，興地隆史，渡部徹郎. 健康長寿を育む歯学教育コンソーシアム -第５報- ５年間を終えて今後の展望. 第38回日本歯科医学教育学会学術大会 2019.07.19 博多

  20. Kazuki Takahashi, Katarzyna A. Inoue, Yasuhiro Yoshimatsu, Atsushi Kaida, Kei Takahashi, Shimpei Kubota, Akinari Sugauchi, Toshihiro Uchihashi, Susumu Tanaka, Mikihiko Kogo, Masahiko Miura, Kohei Miyazono and Tetsuro Watabe. . TGF-β-induced cell cycle arrest is associated with increased migration and metastasis of oral squamous carcinoma cells. AACR-JCA Joint Conference 2019.02.09 Maui,Hawaii

  21. Tetsuro Watabe. TGF-β family signals in the formation and maintenance of lymphatic systems.. The 41st Annual Meeting of the Molecular Biology Society of Japan 2018.11.28 Yokohama,Japan

  22. Tetsuro Watabe. BMP family signals in the formation and maintenance of vascular systems.. 12th International BMP Conference 2018.10.27 Tokyo,Japan

  23. Tetsuro Watabe. Roles of TGF-β family signals during the formation and maintenance of vascular systems.. Kitasato Research Forum 2018 2018.07.09 Tokyo

  24. Tetsuro Watabe. TGF-β family signals in the formation and maintenance of vascular systems.. International Vascular Biology Meeting 2018 2018.06.03 Helsinki,Finland

  25. Tetsuro Watabe. TGF-β signals induce endothelial-to-mesenchymal transition of lymphatic endothelial cells by decreasing PROX1 expression. Lymphatics Gordon Research Conference 2018.03.11 Lucca(Barga)、IT

  26. Tetsuro Watabe. Roles of signaling networks during tumor angiogenesis. CardioVascular and Metabolic Week 2017 2017.12.08 Osaka

  27. Katarzyna A. Inoue, Kazuki Takahashi, Takumi Matsuda, Yasuhiro Yoshimatsu, Miki Yokoyama and Tetsuro Watabe. Exosomes secreted by oral squamous carcinoma cells undergoing TGF-β-induced epithelial to mesenchymal transition. ConBio2017 2017.12.06 神戸市

  28. Tetsuro Watabe, Kazuki Takahashi, Takumi Matsuda, Yasuhiro Yoshimatsu, Atsushi Kaida, Masahiko Miura and Katarzyna A. Inoue. Relationship between cell cycle arrest and epithelial to mesenchymal transition (EMT) induced by TGF-β in oral squamous carcinoma cell. ERATO/AMED-CREST/PRESTO Joint International Symposium 2017.12.04 Kyoto

  29. H. Morisaki, I. Yamanaka, T. Ohata, T. Kosho, K. Wakui, Y. Fukushima, M. Masuno, K. Takahashi, T. Watabe, T. Morisaki. TMEPAI mutation causes MFS/LDS-like phenotypes in 2 Japanese families.. The American Society of Human Genetics 2017 2017.10.17 Orlando

  30. Tetsuro Watabe. Roles of TGF-βfamily signals during endothelial-to- mesenchymal transition. the TGFbeta meeting in Uppsala 2017 2017.09.02 Sweden

  31. Tetsuro Watabe. Targeting signaling networks in tumor microenvironment. 1st International Cancer Precision Medical Conference 2017.06.29 Tokyo

  32. Teturo Watabe. Roles of signaling and transcriptional networks in the formation and maintenance of lymphatic vessels. Kitasato Research Forum 2017 on Vascular Biology 2017.05.31 Kitasato University School of Medicine

  33. Ershu Ren, Ippei Watari, Hsu Jui-Chin, Mariko Mizumachi-Kubono, Katarzyna Anna Podyma-Inoue, Tetsuro Watabe, Takashi Ono. Unilateral nasal obstruction effects gustatory function in rats. The 39 th Annual Scientific Conference on Dental Research 2017.03.31 Ho Chi Minh city, Vietnam

  34. 高橋 和樹、井上 カタジナアンナ、吉松 康裕、原田 浩徳、渡部 徹郎. 口腔がんの悪性化におけるTGF-βシグナルの役割. 第39回日本分子生物学会年会 2016.12 横浜市

  35. Tetsuro Watabe. Dual targeting of vascular endothelial growth factor and bone morphogenetic protein-9/10 impairs tumor growth through inhibition of angiogenesis. 11th International BMP Conference 2016.10.28 Boston

  36. Katarzyna A. Podyma-Inoue, Miki Yokoyama and Tetsuro Watabe. Characterization of extracellular vesicles isolated from osteoblastic cells lines. 第89回日本生化学会大会 2016.09 仙台市

  37. Tetsuro Watabe. Roles of TGF-ß signals in endothelial-to-mesenchymal transition (EndMT) of lymphatic endothelial cells. Gordon Research Conference Lymphatics 2016.03.23 Ventura, USA

  38. Tetsuro Watabe, Yuichi Akatsu, Yasuhiro Yoshimatsu, Kohei Miyazono. Dual targeting of vascular endothelial growth factor and bone morphogenetic protein-9/10 impairs tumor growth through inhibition of angiogenesis. 10th AACR-JCA Joint Conference 2016.02.17 Maui, Hawaii, USA

  39. Katarzyna A. Podyma-Inoue, Anupama R. Rajapakshe, Takuya Moriwaki, Tetsuro Watabe and Miki Yokoyama. Heparan sulfate proteoglycan and intracellular transport; clues from proteomic analysis of transport vesicles. 第88回日本生化学会大会 2015.12 神戸

  40. Tetsuro Watabe. Roles of signaling networks during the formation and maintenance of vascular systems. Asia-Australia Vascular Biology Meeting 2015.10 Busan, Korea

  41. Tetsuro Watabe. Roles of signal networks during the formation of vascular systems. KAIST Vascular Biology Meeting 2015.10 Daejeon, Korea

  42. Tetsuro Watabe. Roles of Signaling and Transcriptional Networks during Endothelial-to-Mesenchymal Transition. 10th World Congress for Microcirculation 2015.09 Kyoto

  43. Roles of signaling networks during endothelial-mesenchymal transition. TGF-β Meeting in Uppsala 2015.08 Uppsala, Sweden

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