Personnel Information

写真a

TAKEBE Takanori


Job title

Professor

Birth date

1986

Mail Address

ttakebe.ior@tmd.ac.jp

Field Introduction URL

https://takebelab.com/

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Campus Career 【 display / non-display 】

  • 2015.04
    -
    2018.05
    Tokyo Medical and Dental University， Graduate School of Health Care Sciences， Biomedical Laboratory Sciences， Life Sciences and Bio-informatics， Biochemistry and Biophysics， Visiting Lecturer
  • 2016.05
    -
    2017.03
    Tokyo Medical and Dental University， Graduate School of Health Care Sciences， Biomedical Laboratory Sciences， Life Sciences and Bio-informatics， Biochemistry and Biophysics， Visiting Lecturer
  • 2018.02
    -
    2018.05
    Tokyo Medical and Dental University， Institute of Research， Professor
  • 2018.06
    -
    2020.07
    Tokyo Medical and Dental University， Institute of Research， Division of Advanced Research， Professor
  • 2019.04
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Division of Advanced Therapeutic Sciences， ， Professor
  • 2020.08
    -
    2021.01
    Tokyo Medical and Dental University， Institute of Research， Division of Advanced Research， Professor
  • 2021.02
    -
    2022.02
    Tokyo Medical and Dental University， Institute of Research， Division of Advanced Research， Professor
  • 2022.03
    -
    Now
    Tokyo Medical and Dental University， Institute of Research， a， Professor

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External Career 【 display / non-display 】

  • 2023.01
    -
    Now
    , Professor
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Academic Society Affiliations 【 display / non-display 】

  • International Society for Stem Cell Research (ISSCR)

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Academic Activity 【 display / non-display 】

  • International Society for Stem Cell Research (ISSCR) Board of Directors
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Qualification Acquired 【 display / non-display 】

  • Doctor

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Published Papers & Misc 【 display / non-display 】

  1. Matsuzaki T, Kawano Y, Horikiri M, Shimokawa Y, Yamazaki T, Okuma N, Koike H, Kimura M, Kawamura R, Yoneyama Y, Furuichi Y, Hakuno F, Takahashi SI, Nakabayashi S, Okamoto S, Nakauchi H, . Preparation of mechanically patterned hydrogels for controlling the self-condensation of cells STAR protocols. 2023.07; 4 (3): 102471.

  2. Kimura M, Iguchi T, Iwasawa K, Dunn A, Thompson W, Yoneyama Y, Chaturvedi P, Zorn A, Wintzinger M, Quattrocelli M, Watanabe-Chailland M, Zhu G, Fujimoto M, Kumbaji M, Kodaka A, Gindin Y, Chung C, Myers R, Subramanian G, Hwa V, Takebe T. En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH Cell. 2022.10; 185 (22): 4216-4232.e16.

  3. Liu Y, Kimura M, Vijayakumar A, Murakami E, Takebe T, Subramanian M, Auwerx J. ENHANCEMENT OF DE NOVO NAD plus BIOSYNTHESIS BY NOVEL ACMSD INHIBITORS IMPROVES MITOCHONDRIAL FUNCTION IN iPSC-DERIVED HUMAN LIVER ORGANOID Hepatology. 2022.10; 76 S706.

  4. Matsuzaki T, Shimokawa Y, Koike H, Kimura M, Kawano Y, Okuma N, Kawamura R, Yoneyama Y, Furuichi Y, Hakuno F, Takahashi S, Nakabayashi S, Okamoto S, Nakauchi H, Taniguchi H, Takebe T, Yoshikawa H. Mechanical guidance of self-condensation patterns of differentiating progeny iScience. 2022.09; 25 (10): 105109.

  5. Wu Y, Oda M, Hayashi Y, Takebe T, Nagata S, Wang C, Mori K. Blood Vessel Segmentation from Low-Contrast and Wide-Field Optical Microscopic Images of Cranial Window by Attention-Gate-Based Network IEEE. 2022.08; 1864-1873.

  6. Lancaster M, Morris S, Takebe T, Qian L, Gao S, Huch M. Anniversary reflections: Inspiring discoveries and the future of the field Cell Stem Cell. 2022.06; 29 (66): 879-881.

  7. Mituru Mizuno,Takahisa Matsuzaki,Nobutake Ozeki,Hisako Katano,Hideyuki Koga,Takanori Takebe,Hiroshi Yoshikawa,Ichiro Sekiya. Cell membrane fluidity and ROS resistance define DMSO tolerance of cryopreserved synovial MSCs and HUVECs. Stem Cell Research & Therapy. 2022.05; 13 (1): 177. ( PubMed, DOI )

  8. Jurickova I, Bonkowski E, Angerman E, Novak E, Huron A, Akers G, Iwasawa K, Braun T, Hadar R, Hooker M, Han S, Cutler D, Okou D, Kugathasan S, Jegga A, Wells J, Takebe T, Mollen K, Haberman Y, Denson L. Eicosatetraynoic Acid and Butyrate Regulate Human Intestinal Organoid Mitochondrial and Extracellular Matrix Pathways Implicated in Crohn’s Inflammatory Bowel Diseases. 2022.03; 28 (7): 988-1003.

  9. Tominaga K, Kechele D, Sanchez G, McCauley H, Enriquez J, Vales S, Jurickova I, Denson L, Takebe T, Helmrath M, Zorn A, Wells J. GENERATION OF HUMAN INTESTINAL ORGANOIDS CONTAINING TISSUE-RESIDENT IMMUNE CELLS Gastroenterology. 2022.02; 62 (3): S57.

  10. Dunn A, Cai Y, Iwasawa K, Kimura M, Takebe T . Synthesis and application of POLYseq for profiling human liver organoids STAR Protoc. 2021.12; 2 (4): 100976. ( PubMed, DOI )

  11. Reza HA, Ryo O, Takebe T. Organoid Transplant Approaches for the Liver. Transplant international : official journal of the European Society for Organ Transplantation. 2021.10; ( PubMed, DOI )

  12. Naraoka Y, Mabuchi Y, Yoneyama Y, Suto EG, Hisamatsu D, Ikeda M, Ito R, Nakamura T, Takebe T, Akazawa C. Isolation and Characterization of Tissue Resident CD29-Positive Progenitor Cells in Livestock to Generate a Three-Dimensional Meat Bud. Cells. 2021.09; 10 (9): ( PubMed, DOI )

  13. Dunn A, Cai Y, Iwasawa K, Kimura M, Takebe T. POLYseq: A poly(β-amino ester)-based vector for multifunctional cellular barcoding. Stem cell reports. 2021.09; 16 (9): 2149-2158. ( PubMed, DOI )

  14. Iwasawa K, Takebe T. Organogenesis in vitro. Current opinion in cell biology. 2021.08; 73 84-91. ( PubMed, DOI )

  15. Marsee A, Roos FJM, Verstegen MMA, HPB Organoid Consortium., Gehart H, de Koning E, Lemaigre F, Forbes SJ, Peng WC, Huch M, Takebe T, Vallier L, Clevers H, van der Laan LJW, Spee B. Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids. Cell stem cell. 2021.05; 28 (5): 816-832. ( PubMed, DOI )

  16. Okabe R, Chen-Yoshikawa TF, Yoneyama Y, Kobayashi E, Date H, Takebe T. Mammalian enteral ventilation ameliorates respiratory failure Med. 2021.05; 2 (6): 773-783 . ( DOI )

  17. Annabi N, Baker M, Boettiger A, Chakraborty D, Chen Y, Corbett KS, Correia B, Dahlman J, de Oliveira T, Ertuerk A, Yanik MF, Henaff E, Huch M, Iliev ID, Jacobs T, Junca H, Keung A, Kolodkin-Gal I, Krishnaswamy S, Lancaster M, Macosko E, Martínez-Núñez MA, Miura K, Molloy J, Cruz AO, Platt RJ, Posey AD Jr, Shao H, Simunovic M, Slavov N, Takebe T, Vandenberghe LH, Varshney RK, Wang J. Voices of biotech research. Nature biotechnology. 2021.03; 39 (3): 281-286. ( PubMed, DOI )

  18. Dobrindt K, Hoagland DA, Seah C, Kassim B, O'Shea CP, Murphy A, Iskhakova M, Fernando MB, Powell SK, Deans PJM, Javidfar B, Peter C, Møller R, Uhl SA, Garcia MF, Kimura M, Iwasawa K, Crary JF, Kotton DN, Takebe T, Huckins LM, tenOever BR, Akbarian S, Brennand KJ. Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection. Stem cell reports. 2021.03; 16 (3): 505-518. ( PubMed, DOI )

  19. Koike H, Iwasawa K, Ouchi R, Maezawa M, Kimura M, Kodaka A, Nishii S, Thompson WL, Takebe T. Engineering human hepato-biliary-pancreatic organoids from pluripotent stem cells. Nature protocols. 2021.02; 16 (2): 919-936. ( PubMed, DOI )

  20. Lewis K, Yoshimoto M, Takebe T. Fetal liver hematopoiesis: from development to delivery. Stem cell research & therapy. 2021.02; 12 (1): 139. ( PubMed, DOI )

  21. Funata M, Nio Y, Erion DM, Thompson WL, Takebe T. The promise of human organoids in the digestive system. Cell death and differentiation. 2021.01; 28 (1): 84-94. ( PubMed, DOI )

  22. Fang H, Geng S, Hao M, Chen Q, Liu M, Liu C, Tian Z, Wang C, Takebe T, Guan JL, Chen Y, Guo Z, He W, Diao J. Simultaneous Zn<sup>2+</sup> tracking in multiple organelles using super-resolution morphology-correlated organelle identification in living cells. Nature communications. 2021.01; 12 (1): 109. ( PubMed, DOI )

  23. Thompson WL, Takebe T. Human liver model systems in a dish. Development, growth & differentiation. 2021.01; ( PubMed, DOI )

  24. Tamaoki N, Siebert S, Maeda T, Ngoc-H Ha, Good M L, Huang Y, Vodnala S K, Haro-Mora J J, Uchida N, Tisdale J F, Sweeney C L, Choi U, Brault J, Koontz S, Malech H L, Yamazaki Y, Isonaka R, Goldstein . Self-organized yolk sac-like organoids allow for scalable generation of multipotent hematopoietic progenitor cells from human induced pluripotent stem cells bioRxiv. 2021.01; 3 (4): 100460.

  25. Hayashi H, Osaka S, Sakabe K, Fukami A, Kishimoto E, Aihara E, Sabu Y, Mizutani A, Kusuhara H, Naritaka N, Zhang W, Huppert SS, Sakabe M, Nakamura T, Hu YC, Mayhew C, Setchell K, Takebe T, Asai A. Modeling Human Bile Acid Transport and Synthesis in Stem Cell-Derived Hepatocytes with a Patient-Specific Mutation. Stem cell reports. 2020.12; ( PubMed, DOI )

  26. Sekine K, Ogawa S, Tsuzuki S, Kobayashi T, Ikeda K, Nakanishi N, Takeuchi K, Kanai E, Otake Y, Okamoto S, Kobayashi T, Takebe T, Taniguchi H. Generation of human induced pluripotent stem cell-derived liver buds with chemically defined and animal origin-free media. Scientific reports. 2020.10; 10 (1): 17937. ( PubMed, DOI )

  27. Koido M, Kawakami E, Fukumura J, Noguchi Y, Ohori M, Nio Y, Nicoletti P, Aithal GP, Daly AK, Watkins PB, Anayama H, Dragan Y, Shinozawa T, Takebe T. Polygenic architecture informs potential vulnerability to drug-induced liver injury. Nature medicine. 2020.10; 26 (10): 1541-1548. ( PubMed, DOI )

  28. Shinozawa T, Kimura M, Cai Y, Saiki N, Yoneyama Y, Ouchi R, Koike H, Maezawa M, Zhang RR, Dunn A, Ferguson A, Togo S, Lewis K, Thompson W, Asai A, Takebe T. High-Fidelity Drug-Induced Liver Injury Screen Using Human Pluripotent Stem Cell-Derived Organoids. Gastroenterology. 2020.10; ( PubMed, DOI )

  29. Kobayashi Naritaka, Togo Shodai, Matsuzaki Takahisa, Hashiseko Kaede, Kawamura Ryuzo, Suganuma Masami, Nakabayashi Seiichiro, Yoneyama Yosuke, Ouchi Rie, Takebe Takanori, Yoshikawa Hiroshi Y.. Stiffness distribution analysis in indentation depth direction reveals clear mechanical features of cells and organoids by using AFM APPLIED PHYSICS EXPRESS. 2020.09; 13 (9):

  30. Okabe R, Chen-Yoshikawa TF, Yoshizawa A, Hirashima T, Saito M, Date H, Takebe T. Orthotopic foetal lung tissue direct injection into lung showed a preventive effect against paraquat-induced acute lung injury in mice. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 2020.09; 58 (3): 638-645. ( PubMed, DOI )

  31. Han L, Chaturvedi P, Kishimoto K, Koike H, Nasr T, Iwasawa K, Giesbrecht K, Witcher PC, Eicher A, Haines L, Lee Y, Shannon JM, Morimoto M, Wells JM, Takebe T, Zorn AM. Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis. Nature communications. 2020.08; 11 (1): 4158. ( PubMed, DOI )

  32. Sakabe K, Takebe T, Asai A. Organoid Medicine in Hepatology. Clinical liver disease. 2020.01; 15 (1): 3-8. ( PubMed, DOI )

  33. Thompson WL, Takebe T. Generation of multi-cellular human liver organoids from pluripotent stem cells. Methods in cell biology. 2020; 159 47-68. ( PubMed, DOI )

  34. Fang H, Yao S, Chen Q, Liu C, Cai Y, Geng S, Bai Y, Tian Z, Zacharias AL, Takebe T, Chen Y, Guo Z, He W, Diao J. De Novo-Designed Near-Infrared Nanoaggregates for Super-Resolution Monitoring of Lysosomes in Cells, in Whole Organoids, and in Vivo. ACS nano. 2019.12; 13 (12): 14426-14436. ( PubMed, DOI )

  35. Liu T, Zhou L, Yang K, Iwasawa K, Kadekaro AL, Takebe T, Andl T, Zhang Y. The β-catenin/YAP signaling axis is a key regulator of melanoma-associated fibroblasts. Signal transduction and targeted therapy. 2019.12; 4 63. ( PubMed, DOI )

  36. Koike H, Iwasawa K, Ouchi R, Maezawa M, Giesbrecht K, Saiki N, Ferguson A, Kimura M, Thompson WL, Wells JM, Zorn AM, Takebe T. Modelling human hepato-biliary-pancreatic organogenesis from the foregut-midgut boundary. Nature. 2019.10; 574 (7776): 112-116. ( PubMed, DOI )

  37. Takebe T. Creativity for a cure. Nature medicine. 2019.06; 25 (6): 868. ( PubMed, DOI )

  38. Takebe T, Wells JM. Organoids by design. Science (New York, N.Y.). 2019.06; 364 (6444): 956-959. ( PubMed, DOI )

  39. Ouchi R, Togo S, Kimura M, Shinozawa T, Koido M, Koike H, Thompson W, Karns RA, Mayhew CN, McGrath PS, McCauley HA, Zhang RR, Lewis K, Hakozaki S, Ferguson A, Saiki N, Yoneyama Y, Takeuchi I, Mabuchi Y, Akazawa C, Yoshikawa HY, Wells JM, Takebe T. Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids. Cell metabolism. 2019.05; ( PubMed, DOI )

  40. Okabe R., Chen-Yoshikawa T., Yoshizawa A., Hirashima T., Gochi F., Yamagishi H., Takahagi A., Saito M., Ohsumi A., Nakajima D., Hamaji M., Date H., Takebe T.. Orthotopic Implantation with Immature Mouse Fetal Lung Did Not Self-Organize Airways Structures, but Improved Prognosis of Mice with Paraquat-Induced Severe Lung Injury JOURNAL OF HEART AND LUNG TRANSPLANTATION. 2019.04; 38 (4): S257.

  41. Asai Akihiro, Hayashi Hisamitsu, Ibrahim Leena, Ssakabe Kokoro, Brandser Nicholas Ryan, Ishii Ken, Takebe Takanori, Aihara Eitaro. Truncating Mutation of Bsep/ABCB11 in Human Hepatocytes Derived from Induced Pluripotent Stem Cells Increases Their Susceptibility to Bile Acid Injury HEPATOLOGY. 2018.10; 68 83A-84A.

  42. Nie YZ, Zheng YW, Miyakawa K, Murata S, Zhang RR, Sekine K, Ueno Y, Takebe T, Wakita T, Ryo A, Taniguchi H. Recapitulation of hepatitis B virus-host interactions in liver organoids from human induced pluripotent stem cells. EBioMedicine. 2018.08; ( PubMed, DOI )

  43. Ayabe H, Anada T, Kamoya T, Sato T, Kimura M, Yoshizawa E, Kikuchi S, Ueno Y, Sekine K, Camp JG, Treutlein B, Ferguson A, Suzuki O, Takebe T, Taniguchi H. Optimal Hypoxia Regulates Human iPSC-Derived Liver Bud Differentiation through Intercellular TGFB Signaling. STEM CELL REPORTS. 2018.08; 11 (2): 306-316. ( PubMed, DOI )

  44. Matsuzaki T, Matsumoto S, Kasai T, Yoshizawa E, Okamoto S, Yoshikawa HY, Taniguchi H, Takebe T. Defining Lineage-Specific Membrane Fluidity Signatures that Regulate Adhesion Kinetics. Stem Cell Reports. 2018.08; 11 (4): 852-860. ( DOI )

  45. Kimura, M., Azuma, M., Zhang, R. -R., Thompson, W., Mayhew, C. N., & Takebe, T.. Digitalized Human Organoid for Wireless Phenotyping. iScience. 2018.07; 4 294-301. ( DOI )

  46. Rao Mahendra S., Pei Ying, Garcia Thelma Y., Chew Shereen, Kasai Toshiharu, Hisai Tomoko, Taniguchi Hideki, Takebe Takanori, Lamba Deepak A., Zeng Xianmin. Illustrating the potency of current Good Manufacturing Practice-compliant induced pluripotent stem cell lines as a source of multiple cell lineages using standardized protocols CYTOTHERAPY. 2018.06; 20 (6): 861-872. ( PubMed, DOI )

  47. Takebe Takanori, Wells James M., Helmrath Michael A., Zorn Aaron M.. Organoid Center Strategies for Accelerating Clinical Translation CELL STEM CELL. 2018.06; 22 (6): 806-809. ( PubMed, DOI )

  48. Takahashi Yoshinobu, Sekine Keisuke, Kin Tatsuya, Takebe Takanori, Taniguchi Hideki. Self-Condensation Culture Enables Vascularization of Tissue Fragments for Efficient Therapeutic Transplantation CELL REPORTS. 2018.05; 23 (6): 1620-1629. ( PubMed, DOI )

  49. Takahashi Y, Takebe T, Taniguchi H. Methods for Generating Vascularized Islet-Like Organoids Via Self-Condensation. Current protocols in stem cell biology. 2018.05; 45 (1): e49. ( PubMed, DOI )

  50. Zhang Ran-Ran, Koido Masaru, Tadokoro Tomomi, Ouchi Rie, Matsuno Tatsuya, Ueno Yasuharu, Sekine Keisuke, Takebe Takanori, Taniguchi Hideki. Human iPSC-Derived Posterior Gut Progenitors Are Expandable and Capable of Forming Gut and Liver Organoids STEM CELL REPORTS. 2018.03; 10 (3): 780-793. ( PubMed, DOI )

  51. Lewis K, Takebe T. Tumoroid à la carte: Path for personalization. Hepatology (Baltimore, Md.). 2018.02; ( PubMed, DOI )

  52. Takebe Takanori, Sekine Keisuke, Kimura Masaki, Yoshizawa Emi, Ayano Satoru, Koido Masaru, Funayama Shizuka, Nakanishi Noriko, Hisai Tomoko, Kobayashi Tatsuya, Kasai Toshiharu, Kitada Rina, Mori Akira, Ayabe Hiroaki, Ejiri Yoko, Amimoto Naoki, Yamazaki Yosuke, Ogawa Shimpei, Ishikawa Momotaro, Kiyota Yasujiro, Sato Yasuhiko, Nozawa Kohei, Okamoto Satoshi, Ueno Yasuharu, Taniguchi Hideki. Massive and Reproducible Production of Liver Buds Entirely from Human Pluripotent Stem Cells CELL REPORTS. 2017.12; 21 (10): 2661-2670. ( PubMed, DOI )

  53. Takebe Takanori, Zhang Boyang, Radisic Milica. Synergistic Engineering: Organoids Meet Organs-on-a-Chip CELL STEM CELL. 2017.09; 21 (3): 297-300. ( PubMed, DOI )

  54. Takebe Takanori, Sekine Keisuke, Camp Gray, Treutlein Barbara. Human Liver Bud Organoid Models Development CELL SYSTEMS. 2017.07; 5 (1): 2.

  55. Camp J. Gray, Sekine Keisuke, Gerber Tobias, Loeffler-Wirth Henry, Binder Hans, Gac Malgorzata, Kanton Sabina, Kageyama Jorge, Damm Georg, Seehofer Daniel, Belicova Lenka, Bickle Marc, Barsacchi Rico, Okuda Ryo, Yoshizawa Emi, Kimura Masaki, Ayabe Hiroaki, Taniguchi Hideki, Takebe Takanori, Treutlein Barbara. Multilineage communication regulates human liver bud development from pluripotency NATURE. 2017.06; 546 (7659): 533-+. ( PubMed, DOI )

  56. Lee S., Takahashi Y., Lee K. M., Mizuno M., Nemeno J. G., Takebe T., Lee J. I.. Viability and Functional Assessment of Murine Pancreatic Islets After Transportation Between Korea and Japan (vol 47, pg 738, 2015) TRANSPLANTATION PROCEEDINGS. 2017.04; 49 (3): 616.

  57. Sekine K, Takebe T, Taniguch H. Liver Regeneration Using Cultured Liver Bud. Methods Mol Biol. . 2017.03; ( PubMed, DOI )

  58. Asai Akihiro, Aihara Eitaro, Watson Carey, Mourya Reena, Mizuochi Tatsuki, Shivakumar Pranavkumar, Phelan Kieran, Mayhew Christopher, Helmrath Michael, Takebe Takanori, Wells James, Bezerra Jorge A.. Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells DEVELOPMENT. 2017.03; 144 (6): 1056-1064. ( PubMed, DOI )

  59. Koike Hiroyuki, Zhang Ran-Ran, Ueno Yasuharu, Sekine Keisuke, Zheng Yun-Wen, Takebe Takanori, Taniguchi Hideki. Nutritional modulation of mouse and human liver bud growth through a branched-chain amino acid metabolism DEVELOPMENT. 2017.03; 144 (6): 1018-1024. ( PubMed, DOI )

  60. Shinozawa Tadahiro, Yoshikawa Hiroshi Y., Takebe Takanori. Reverse engineering liver buds through self-driven condensation and organization towards medical application DEVELOPMENTAL BIOLOGY. 2016.12; 420 (2): 221-229. ( PubMed, DOI )

  61. Ito Keitaro, Sakuma Shinya, Kimura Masaki, Takebe Takanori, Kaneko Makoto, Arai Fumihito. Temporal Transition of Mechanical Characteristics of HUVEC/MSC Spheroids Using a Microfluidic Chip with Force Sensor Probes MICROMACHINES. 2016.12; 7 (12): ( DOI )

  62. Koike, H., & Takebe, T.. Generating Mini-Organs in Culture. Current Pathobiology Reports. 2016.06; 4 (2): 59-68. ( DOI )

  63. Takahashi Yoshinobu, Takebe Takanori, Taniguchi Hideki. Engineering pancreatic tissues from stem cells towards therapy REGENERATIVE THERAPY. 2016.03; 3 15-23. ( DOI )

  64. Ito, K., Sakuma, S., Kimura, M., Takebe, T., Kaneko, M., & Arai, F. . STIFFNESS-INDEX MAP BASED ON SINGLE CELL-SPHEROID ANALYSIS USING ROBOT INTEGRATED MICROFLUIDIC CHIIP. CELL TRANSPLANTATION. 2016.01; 25 (5): 951-962. ( DOI )

  65. Asai Akihiro, Aihara Eitaro, Mizuochi Tatsuki, Phelan Kieran, Mayhew Christopher, Shivakumar Pranavkumar, Takebe Takanori, Wells James, Bezerra Jorge A.. Hepatic maturation of induced Pluripotent Stem Cells is regulated by paracrine signals from endothelial and mesenchymal stem cells in culture and during organoid formation HEPATOLOGY. 2015.10; 62 544A.

  66. Takebe Takanori, Enomura Masahiro, Yoshizawa Emi, Kimura Masaki, Koike Hiroyuki, Ueno Yasuharu, Matsuzaki Takahisa, Yamazaki Takashi, Toyohara Takafumi, Osafune Kenji, Nakauchi Hiromitsu, Yoshikawa Hiroshi Y., Taniguchi Hideki. Vascularized and Complex Organ Buds from Diverse Tissues via Mesenchymal Cell-Driven Condensation CELL STEM CELL. 2015.05; 16 (5): 556-565. ( PubMed, DOI )

  67. Lee S., Takahashi Y., Lee K. M., Mizuno M., Nemeno J. G., Takebe T., Lee J. I.. Viability and Functional Assessment of Murine Pancreatic Islets After Transportation Between Korea and Japan TRANSPLANTATION PROCEEDINGS. 2015.04; 47 (3): 738-741. ( DOI )

  68. Rashid Tamir, Takebe Takanori, Nakauchi Hiromitsu. Novel strategies for liver therapy using stem cells GUT. 2015.01; 64 (1): 1-4. ( PubMed, DOI )

  69. Zhang, R. R., Koike, H., & Takebe, T.. The visualization of human organogenesis from stem cells by recapitulating multicellular interactions. Hyper Bio Assembler for 3D Cellular Systems. 2015.01; 275-283. ( DOI )

  70. TANIGUCHI, H., & TAKEBE, T.. Generation of functional human organs from pluripotent stem cells. Japanese Journal of Transplantation. 2015.01; 50 (1): 24-30.

  71. Kawabata Y., Nishihara G. N., Yamaguchi T., Takebe T., Teruya K., Sato T., Soyano K.. The effect of spine postures on the hydrodynamic drag in Epinephelus ongus larvae JOURNAL OF FISH BIOLOGY. 2014.11; 85 (5): 1757-1765. ( DOI )

  72. Takebe Takanori, Kobayashi Shinji, Suzuki Hiromu, Mizuno Mitsuru, Chang Yu-Min, Yoshizawa Emi, Kimura Masaki, Hori Ayaka, Asano Jun, Maegawa Jiro, Taniguchi Hideki. Transient vascularization of transplanted human adult-derived progenitors promotes self-organizing cartilage JOURNAL OF CLINICAL INVESTIGATION. 2014.10; 124 (10): 4325-4334. ( PubMed, DOI )

  73. Takebe T., Taniguchi H.. Human iPSC-Derived Miniature Organs: A Tool for Drug Studies CLINICAL PHARMACOLOGY & THERAPEUTICS. 2014.09; 96 (3): 310-313. ( DOI )

  74. Zheng Yun-Wen, Tsuchida Tomonori, Shimao Taiki, Li Bin, Takebe Takanori, Zhang Ran-Ran, Sakurai Yu, Ueno Yasuharu, Sekine Keisuke, Ishibashi Naoto, Imajima Makiko, Tanaka Takuji, Taniguchi Hideki. The CD133(+)CD44(+) Precancerous Subpopulation of Oval Cells Is a Therapeutic Target for Hepatocellular Carcinoma STEM CELLS AND DEVELOPMENT. 2014.09; 23 (18): 2237-2249. ( PubMed, DOI )

  75. Koike Hiroyuki, Ouchi Rie, Ueno Yasuharu, Nakata Susumu, Obana Yuta, Sekine Keisuke, Zheng Yun-Wen, Takebe Takanori, Isono Kyoichi, Koseki Haruhiko, Taniguchi Hideki. Polycomb Group Protein Ezh2 Regulates Hepatic Progenitor Cell Proliferation and Differentiation in Murine Embryonic Liver PLOS ONE. 2014.08; 9 (8): e104776. ( PubMed, DOI )

  76. Takebe, T., Yoshikawa, H., & Taniguchi, H. . 2S-Ep04 Vascularized and functional organ from pluripotent stem cells. 日本生物工学会大会講演要旨集. 2014.08; 66-105.

  77. Osaki, T., Takebe, T., & Fukuda, J. . 2P-182 Engineering vascularized liver-like tissues with iPS-derived hepatic endoderm spheroids. 日本生物工学会大会講演要旨集. 2014.08; 66-152.

  78. Koike Hiroyuki, Ueno Yasuharu, Naito Takako, Shiina Tomoya, Nakata Susumu, Ouchi Rie, Obana Yuta, Sekine Keisuke, Zheng Yun-Wen, Takebe Takanori, Isono Kyo-ichi, Koseki Haruhiko, Taniguchi Hideki. Ring1B Promotes Hepatic Stem/Progenitor Cell Expansion Through Simultaneous Suppression of Cdkn1a and Cdkn2a in Mice HEPATOLOGY. 2014.07; 60 (1): 323-333. ( PubMed, DOI )

  79. Jo Y. H., Jang I. J., Nemeno J. G., Lee S., Kim B. Y., Nam B. M., Yang W., Lee K. M., Kim H., Takebe T., Kim Y. S., Lee J. I.. Artificial Islets From Hybrid Spheroids of Three Pancreatic Cell Lines TRANSPLANTATION PROCEEDINGS. 2014.05; 46 (4): 1156-1160. ( DOI )

  80. Tsuchida T., Zheng Y. -W., Zhang R. -R., Takebe T., Ueno Y., Sekine K., Taniguchi H.. The Development of Humanized Liver With Rag1 Knockout Rats TRANSPLANTATION PROCEEDINGS. 2014.05; 46 (4): 1191-1193. ( DOI )

  81. Enomoto Y., Enomura M., Takebe T., Mitsuhashi Y., Kimura M., Yoshizawa E., Taniguchi H.. Self-Formation of Vascularized Hepatic Tissue From Human Adult Hepatocyte TRANSPLANTATION PROCEEDINGS. 2014.05; 46 (4): 1243-1246. ( DOI )

  82. Zhang R., Takebe T., Sekine K., Koike H., Zheng Y., Taniguchi H.. Identification of Proliferating Human Hepatic Cells From Human Induced Pluripotent Stem Cells TRANSPLANTATION PROCEEDINGS. 2014.05; 46 (4): 1201-1204. ( DOI )

  83. Takahashi Y., Takebe T., Enomura M., Koike N., Lee S., Nemeno J. G., Sekine K., Lee J. I., Taniguchi H.. High-Resolution Intravital Imaging for Monitoring the Transplanted Islets in Mice TRANSPLANTATION PROCEEDINGS. 2014.05; 46 (4): 1166-1168. ( DOI )

  84. Sekine K., Takebe T., Taniguchi H.. Fluorescent Labeling and Visualization of Human Induced Pluripotent Stem Cells With the Use of Transcription Activator-like Effector Nucleases TRANSPLANTATION PROCEEDINGS. 2014.05; 46 (4): 1205-1207. ( DOI )

  85. Zheng Y. -W., Nie Y. -Z., Tsuchida T., Zhang R. -R., Aoki K., Sekine K., Ogawa M., Takebe T., Ueno Y., Sakakibara H., Hirahara F., Taniguchi H.. Evidence of a Sophisticatedly Heterogeneous Population of Human Umbilical Vein Endothelial Cells TRANSPLANTATION PROCEEDINGS. 2014.05; 46 (4): 1251-1253. ( DOI )

  86. Mizuno M., Takebe T., Kobayashi S., Kinnura S., Masutani M., Lee S., Jo Y. H., Lee Ji, Taniguchi H.. Elastic Cartilage Reconstruction by Transplantation of Cultured Hyaline Cartilage-Derived Chondrocytes TRANSPLANTATION PROCEEDINGS. 2014.05; 46 (4): 1217-1221. ( DOI )

  87. Yang W., Lee S., Jo Y. H., Lee K. M., Nemeno J. G., Nam B. M., Kim B. Y., Jang I. J., Kim H. N., Takebe T., Lee J. I.. Effects of Natural Cartilaginous Extracellular Matrix on Chondrogenic Potential for Cartilage Cell Transplantation TRANSPLANTATION PROCEEDINGS. 2014.05; 46 (4): 1247-1250. ( DOI )

  88. Kim B. Y., Nam B. M., Lee K. M., Jo Y. H., Nemeno J. G., Yang W., Lee S., Kim H., Jang I. J., Takebe T., Lee J. I.. Effect of Preservation Conditions on Cartilage Tissue for Cell Transplantation TRANSPLANTATION PROCEEDINGS. 2014.05; 46 (4): 1139-1144. ( DOI )

  89. Nam B. M., Kim B. Y., Jo Y. H., Lee S., Nemeno J. G., Yang W., Lee K. M., Kim H., Jang I. J., Takebe T., Lee J. I.. Effect of Cryopreservation and Cell Passage Number on Cell Preparations Destined for Autologous Chondrocyte Transplantation TRANSPLANTATION PROCEEDINGS. 2014.05; 46 (4): 1145-1149. ( DOI )

  90. Okuda R, Sekine K, Hisamatsu D, Ueno Y, Takebe T, Zheng YW, Taniguchi H. Tropism of cancer stem cells to a specific distant organ. In vivo (Athens, Greece). 2014.05; 28 (3): 361-5. ( PubMed )

  91. Takebe, T., Koike, N., Sekine, K., Fujiwara, R., Amiya, T., Zheng, Y. -W., & Taniguchi, H. . Engineering of human hepatic tissue with functional vascular networks. ORGANOGENESIS. 2014.04; 10 (2): 260-267. ( DOI )

  92. Mizuno Mitsuru, Kobayashi Shinji, Takebe Takanori, Kan Hiroomi, Yabuki Yuichiro, Matsuzaki Takahisa, Yoshikawa Hiroshi Y., Nakabayashi Seiichiro, Ik Lee Jeong, Maegawa Jiro, Taniguchi Hideki. Brief Report: Reconstruction of Joint Hyaline Cartilage by Autologous Progenitor Cells Derived from Ear Elastic Cartilage STEM CELLS. 2014.03; 32 (3): 816-821. ( PubMed, DOI )

  93. Takebe Takanori, Zhang Ran-Ran, Koike Hiroyuki, Kimura Masaki, Yoshizawa Emi, Enomura Masahiro, Koike Naoto, Sekine Keisuke, Taniguchi Hideki. Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant NATURE PROTOCOLS. 2014.02; 9 (2): 396-409. ( PubMed, DOI )

  94. Takebe, T., & Taniguchi, H. . Vascularized and functional liver devided from human induced pluripotent stem cells by recapitulating organogenesis. Yokohama Medical Journal. 2014.01; 65 (4): 503-507.

  95. Ohgane, H., Takebe, T., Sekine, K., & Taniguchi, H.. Efficient generation of mature hepatocyte-like cells from human iPSCs. 2014.01;

  96. Zhang, R. -R., Takebe, T., Miyazaki, L., Takayama, M., Koike, H., Kimura, M., . . . Taniguchi, H.. Efficient hepatic differentiation of human induced pluripotent stem cells in a three-dimensional microscale culture. Methods Mol Biol. 2014.01; 1210 131-141. ( DOI )

  97. Tanaka Hiroyasu, Tanaka Shin, Sekine Keisuke, Kita Sayaka, Okamura Ai, Takebe Takanori, Zheng Yun-Wen, Ueno Yasuharu, Tanaka Junzo, Taniguchi Hideki. The generation of pancreatic beta-cell spheroids in a simulated microgravity culture system BIOMATERIALS. 2013.07; 34 (23): 5785-5791. ( PubMed, DOI )

  98. Takebe Takanori, Sekine Keisuke, Enomura Masahiro, Koike Hiroyuki, Kimura Masaki, Ogaeri Takunori, Zhang Ran-Ran, Ueno Yasuharu, Zheng Yun-Wen, Koike Naoto, Aoyama Shinsuke, Adachi Yasuhisa, Taniguchi Hideki. Vascularized and functional human liver from an iPSC-derived organ bud transplant NATURE. 2013.07; 499 (7459): 481-+. ( PubMed, DOI )

  99. Koike Hiroyuki, Kubota Koji, Sekine Keisuke, Takebe Takanori, Ouchi Rie, Zheng Yun-Wen, Ueno Yasuharu, Tanigawa Naoki, Taniguchi Hideki. Establishment of automated culture system for murine induced pluripotent stem cells BMC BIOTECHNOLOGY. 2012.11; 12 81. ( PubMed, DOI )

  100. Takasaki K., Takebe T.. An h-dependent formulation of the Kadomtsev-Petviashvili hierarchy THEORETICAL AND MATHEMATICAL PHYSICS. 2012.05; 171 (2): 683-690. ( DOI )

  101. Takebe T., Sekine K., Suzuki Y., Enomura M., Tanaka S., Ueno Y., Zheng Y. -W., Taniguchi H.. Self-Organization of Human Hepatic Organoid by Recapitulating Organogenesis In Vitro TRANSPLANTATION PROCEEDINGS. 2012.05; 44 (4): 1018-1020. ( DOI )

  102. Sekine K., Takebe T., Enomura M., Matsui C., Tanaka H., Taniguchi H.. Regenerative Medicine Approach as an Alternative Treatment to Islet Transplantation TRANSPLANTATION PROCEEDINGS. 2012.05; 44 (4): 1104-1106. ( DOI )

  103. Takebe T., Kobayashi S., Kan H., Suzuki H., Yabuki Y., Mizuno M., Adegawa T., Yoshioka T., Tanaka J., Maegawa J., Taniguchi H.. Human Elastic Cartilage Engineering from Cartilage Progenitor Cells Using Rotating Wall Vessel Bioreactor TRANSPLANTATION PROCEEDINGS. 2012.05; 44 (4): 1158-1161. ( DOI )

  104. Sekine K., Takebe T., Suzuki Y., Kamiya A., Nakauchi H., Taniguchi H.. Highly Efficient Generation of Definitive Endoderm Lineage from Human Induced Pluripotent Stem Cells TRANSPLANTATION PROCEEDINGS. 2012.05; 44 (4): 1127-1129. ( DOI )

  105. Takebe T., Koike N., Sekine K., Enomura M., Chiba Y., Ueno Y., Zheng Y. -W., Taniguchi H.. Generation of Functional Human Vascular Network TRANSPLANTATION PROCEEDINGS. 2012.05; 44 (4): 1130-1133. ( DOI )

  106. Kobayashi Shinji, Takebe Takanori, Zheng Yun-Wen, Mizuno Mitsuru, Yabuki Yuichiro, Maegawa Jiro, Taniguchi Hideki. Presence of Cartilage Stem/Progenitor Cells in Adult Mice Auricular Perichondrium PLOS ONE. 2011.10; 6 (10): e26393. ( PubMed, DOI )

  107. Kobayashi Shinji, Takebe Takanori, Inui Midori, Iwai Sayaka, Kan Hiroomi, Zheng Yun-Wen, Maegawa Jiro, Taniguchi Hideki. Reconstruction of human elastic cartilage by a CD44(+) CD90(+) stem cell in the ear perichondrium PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011.08; 108 (35): 14479-14484. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Takanori Takebe. Stem cell technology for studying hepatology and hepatitis viruses. 2023 International Hepatitis B Virus Meeting 2023.09.19

  2. Takanori Takebe. Developmental Origin of the Liver. Society for Developmental Biology (SDB) 2023 annual meeting 2023.07.21 Chicago

  3. Takanori Takebe. Promise and Impact of Organoid Medicine. AMED-SCN Showcase Event 2023 2023.07.19

  4. Takanori Takebe. Modeling Hepato-biliary-pancreatic Organogenesis in a Dish. The 87th Cold Spring Harbor Laboratory Symposium on Quantitative Biology - Stem Cells 2023.05.31

  5. Takanori Takebe. Modeling Hepato-Biliary-Pancreatic Organogenesis. Keystone Symposia 2023.02.08

  6. Takanori Takebe. Human Organoids Towards Precision Hepatology. The Department of Pediatrics of UTSW and Children’s Medical Center, Scientific conference 2023.01.17

  7. 武部貴則. ストリート・メディカルの可能性. 日本内科学会 第67回近畿支部生涯教育講演会 2022.12.10 Web

  8. Takanori Takebe. From Invention, to Innovation. 日本薬物動態学会 2022.11.08

  9. Takanori Takebe. Human Organoids Toward Precision Hepatology. AASLD The Liver Meeting 2022 2022.11.07

  10. Takanori Takebe. Engineering Complex Liver Organoids for Advanced Disease Modeling. 2022 James W. Freston Single Topic Conference 2022.10.07

  11. Takanori Takebe. Modeling Steatohepatitis in Humans with Liver Organoids. Keystone Symposia 2022.08.09

  12. 武部貴則. 多能性幹細胞を用いた肝胆膵発生システム. 発生生物学会第55回大会 2022.06.01

  13. Takebe T. Organoid Medicine for Precision Hepatology,. Arias symposium 2021.11.18

  14. Takebe T. Human organoids in precision toxicology. 2021 KSOT/KEMS conference inKorea 2021.11.01

  15. Takebe T. Using Stem Cell and Organoid Biology to Model Complex Human Development and Identify New Therapies. 2021 Virtual FASEB SRC “The Gastrointestinal Tract XIX Conference 2021.08.04

  16. Takebe T. Modeling hepato-biliary-pancreatic organogenesis towards therapy. 第18回幹細胞シンポジウム 2021.05.21

  17. Takebe T. Engineering Organoids and Organs. Cell Symposia 2021.04.26

  18. Takebe T. Liver organoids for sustainability. ISSCR digital/Stem Cells and Global Sustainability 2021.02.04 Web

  19. Takebe T. Promise and Impact of Organoid Medicine. 金沢大学NanoLSI第4回国際シンポジウム 2020.11.26 Web

  20. Takebe T. Organoids by Design. ISSCR Organoids Webinar 2020.10.27 Web

  21. Takebe T. From pluripotency to organoids -finding a clue to reproducibility by live incubation monitoring. ISSCR講演 2020.06.25 web

  22. Sakurako Kobayashi, Satoshi Watanabe, Yosuke Yoneyama, Kousuke Tanimoto, Ryu Nishimura, Sayaka Nagata, Masami Inoue, Kouhei Suzuki, Sei Kakinuma, Kiichiro Tsuchiya, Ryuichi Okamoto, Mamoru Watanabe, Takanori Takebe, Shiro Yui. Conceptual basis of lineage shift between intestinal epithelium and hepatocytes. Keystone Symposia, Tissue Organoids as Models of Host Physiology and Pathophysiology of Disease 2020.01.22 Vancouver（Canada）

  23. Takebe T. Designer’s Organoids by Narrative Engineering. 第42回日本分子生物学会年会 2019.12.06 福岡

  24. Takebe T. Directing Complex Organogenesis from Human iPSC towards Therapy. CiRA国際シンポジウム2019 2019.11.29 京都

  25. Takebe T. The promise of organoid, medicine -from screen to therapeutics. 2019 Taiwan-TMDU Joint Symposium 2019.10.05 台湾

  26. Takebe T. Organoid Medicine for Liver Disorders. ISSCR/KSSCR International Symposium 2019.09.26 Seoul

  27. Takebe T. Making Organoids More Complex Towards Medicine. 3rd HY Indang Symposium 2019.09.25 Seoul

  28. Takebe T. Organoid by design. ISSCR Annual Mtg 2019.06.27 Los Angeles

  29. Takebe T. The Era of Organoid Medicine. 日本再生医療学会International Symposium 2019.03.22

  30. Takebe T. Next-Gen Organoids from Pluripotency. Keystone Symposia 2019.01.29

  31. Takebe T. Translational Embryology Towards Therapy -from human liver organoid experience. 分子生物学会 2018.11.29

  32. Takebe T. The Era of Organoid Medicine-from screen to therapeutics-. Korean organoid symposium 2018.11.07

  33. Takebe T.. Promise of future health impact of liver organoids . NASPGHAN Balistreri Lecture 2018.10.26

  34. Takebe T.. Modeling Early Hepatogenesis Using Human iPSC Towards Organoid Medicine. Cincinnati CuSTOM industrial Symposium 2018.10.19

  35. Takebe T. Modelling Steatosis and Fibrosis in Human Vascularized Organoids. Gordon Research Conference Lipoprotein Metabolism 2018.06.12 Waterville Valley, NH, US

  36. Takebe T. The Era of Organoid Medicine. Korea Organoid Symposoium 2018.05.16 Seoul

  37. 武部貴則. ―次世代オルガノイド医療の展望. 日本小児科学会学術集会・講演 2018.04.20 福岡

  38. 武部貴則. オルガノイド4.0－ヒト臓器創出への展望. JMSA NY Life Science Forum 2018.04.07 NYU Langone Medical Center Farkas Auditorium, NY, USA

  39. 武部貴則. ヒトオルガノイドを用いたホロミクス研究の可能性. 多次元生命システム研究戦略分子・細胞アトラスに関する意見交換会　 2018.03.28 市ヶ谷

  40. Takebe T. The era of Organoid Medicine– Liver Organoid Based Approach. Southern California Stem Cell Seminar Series 2018.03.08

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Awards & Honors 【 display / non-display 】

  • ISSCR Outstanding Young Investigator Award，International Society for Stem Cell Research (ISSCR) ，2023.02

  • National Institutes of Health，National Institutes of Health，2020.10

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Others 【 display / non-display 】

  • Diabetic status modifies the impact of an NAFLD-associated SNP，2022.11

  • Ventilating the rectum to support respiration，2021.05

  • Predicting the future of liver-safe drugs，2020.09

  • Instant Liver, Just Add Water? Not Quite, but a Better Way to Grow Multiple Organs，2019.10

  • 3D miniature livers lead the way to patient-specific drug discovery ，2019.07

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