Personnel Information

写真a

SUZUKI Toshihiko


Job title

Professor

Research Areas, Keywords

infection ad host immune responses, molecular mechanism of pathogen infection
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Graduate School 【 display / non-display 】

  • The University of Tokyo, Graduate School, Division of Medical Sciences, Doctor's Course, Completed

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Campus Career 【 display / non-display 】

  • 2015.07
    -
    2018.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Oral Health Sciences， Bacterial Pathogenesis， Professor
  • 2018.04
    -
    2020.05
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Oral Health Sciences， Bacterial Pathogenesis， Professor
  • 2020.06
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Oral Health Sciences， Bacterial Pathogenesis， Professor
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External Career 【 display / non-display 】

  • 1997.04
    -
    2001.11
    University of Tokyo, Institute of Medical Science, Research Associate
  • 2001.11
    -
    2005.03
    Japan Science and Technology Agency, Precursory Research for Embryonic Science and Technology, Researcher
  • 2001.12
    -
    2006.05
    University of Tokyo, Institute of Medical Science, Junior Associate Professor
  • 2006.06
    -
    2015.06
    University of the Ryukyus, Graduate School of Medicine, Professor
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Published Papers & Misc 【 display / non-display 】

  1. Okano, T; Ashida, H; Komatsu, N; Tsukasaki, M; Iida, T; Iwasawa, M; Takahashi, Y; Takeuchi, Y; Iwata, T; Sasai, M; Yamamoto, M; Takayanagi, H; Suzuki, T. Caspase-11 mediated inflammasome activation in macrophages by systemic infection of <i>A. actinomycetemcomitans</i> exacerbates arthritis INTERNATIONAL JOURNAL OF ORAL SCIENCE. 2024.08; 16 (1): 54. ( PubMed, DOI )

  2. Ali T, Nguyen HM, Abbas N, Takeuchi O, Akira S, Suzuki T, Matsuzaki G, Takaesu G. TAK1-binding proteins (TAB)2 and TAB3 are redundantly required for TLR-induced cytokine production in macrophages. International immunology. 2024.04; 36 (9): 439-450. ( PubMed, DOI )

  3. Ota Y, Yasunaga K, Mahazu S, Prah I, Nagai S, Hayashi T, Suzuki M, Yoshida M, Hoshino Y, Akeda Y, Suzuki T, Gu Y, Saito R. Comparative evaluation of analytical pipelines for illumina short- and nanopore long-read 16S rRNA gene amplicon sequencing with mock microbial communities. Journal of microbiological methods. 2024.04; 221 106929. ( PubMed, DOI )

  4. Mahazu S, Prah I, Ota Y, Hayashi T, Suzuki M, Yoshida M, Hoshino Y, Akeda Y, Suzuki T, Ishino T, Ablordey AS, Saito R. Colistin Resistance Mediated by Mcr-3-Related Phosphoethanolamine Transferase Genes in Aeromonas Species Isolated from Aquatic Environments in Avaga and Pakro Communities in the Eastern Region of Ghana. Infection and drug resistance. 2024; 17 3011-3023. ( PubMed, DOI )

  5. Doan YH, Dennis FE, Takemae N, Haga K, Shimizu H, Appiah MG, Lartey BL, Damanka SA, Hayashi T, Suzuki T, Kageyama T, Armah GE, Katayama K. Emergence of Intergenogroup Reassortant G9P[4] Strains Following Rotavirus Vaccine Introduction in Ghana. Viruses. 2023.12; 15 (12): ( PubMed, DOI )

  6. Suzuki, T; Boonyaleka, K; Okano, T; Iida, T; Yoshida, M; Fukano, H; Hoshino, Y; Iwakura, Y; Ablordey, AS; Ashida, H. Inflammasome-triggered IL-18 controls skin inflammation in the progression of Buruli ulcer PLOS Pathogens. 2023.11; 19 (11): e1011747. ( PubMed, DOI )

  7. Miyamoto K, Sujino T, Harada Y, Ashida H, Yoshimatsu Y, Yonemoto Y, Nemoto Y, Tomura M, Melhem H, Niess JH, Suzuki T, Suzuki T, Suzuki S, Koda Y, Okamoto R, Mikami Y, Teratani T, Tanaka K, Yoshimura A, Sato T, Kanai T. The gut microbiota-induced kynurenic acid recruits GPR35-positive macrophages to promote experimental encephalitis. Cell reports. 2023.08; 42 (8): 113005. ( PubMed, DOI )

  8. Umeda S, Sujino T, Miyamoto K, Yoshimatsu Y, Harada Y, Nishiyama K, Aoto Y, Adachi K, Hayashi N, Amafuji K, Moritoki N, Shibata S, Sasaki N, Mita M, Tanemoto S, Ono K, Mikami Y, Sasabe J, Takabayashi K, Hosoe N, Suzuki T, Sato T, Atarashi K, Teratani T, Ogata H, Nakamoto N, Shiomi D, Ashida H, Kanai T. D-amino Acids Ameliorate Experimental Colitis and Cholangitis by Inhibiting Growth of Proteobacteria: Potential Therapeutic Role in Inflammatory Bowel Disease. Cellular and molecular gastroenterology and hepatology. 2023.08; 16 1011-1031. ( PubMed, DOI )

  9. Boonyaleka K, Okano T, Iida T, Leewananthawet A, Sasai M, Yamamoto M, Ashida H, Suzuki T. Fusobacterium nucleatum infection activates the noncanonical inflammasome and exacerbates inflammatory response in DSS-induced colitis. European journal of immunology. 2023.07; e2350455. ( PubMed, DOI )

  10. Mahazu S, Prah I, Ota Y, Hayashi T, Nukui Y, Suzuki M, Hoshino Y, Akeda Y, Suzuki T, Ishino T, Ablordey A, Saito R. Klebsiella Species and Enterobacter cloacae Isolates Harboring bla(OXA-181) and bla(OXA-48): Resistome, Fitness Cost, and Plasmid Stability. Microbiology spectrum. 2022.12; 10 (6): e0332022. ( PubMed, DOI )

  11. Mahazu Samiratu, Sato Wakana, Ayibieke Alafate, Prah Isaac, Hayashi Takaya, Suzuki Toshihiko, Iwanaga Shiroh, Ablordey Anthony, Saito Ryoichi. Insights and genetic features of extended-spectrum beta-lactamase producing Escherichia coli isolates from two hospitals in Ghana SCIENTIFIC REPORTS. 2022.02; 12 (1): 1843. ( PubMed, DOI )

  12. Yoshida Sumiko, Hatasa Masahiro, Ohsugi Yujin, Tsuchiya Yosuke, Liu Anhao, Niimi Hiromi, Morita Kazuki, Shimohira Tsuyoshi, Sasaki Naoki, Maekawa Shogo, Shiba Takahiko, Hirota Tomomitsu, Okano Tokuju, Hirose Asuka, Ibi Rinko, Noritake Kanako, Tomiga Yuki, Nitta Hiroshi, Suzuki Toshihiko, Takahashi Hirokazu, Miyasaka Naoyuki, Iwata Takanori, Katagiri Sayaka. Porphyromonas gingivalis Administration Induces Gestational Obesity, Alters Gene Expression in the Liver and Brown Adipose Tissue in Pregnant Mice, and Causes Underweight in Fetuses FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. 2022.01; 11 745117. ( PubMed, DOI )

  13. Mahazu Samiratu, Prah Isaac, Ayibieke Alafate, Sato Wakana, Hayashi Takaya, Suzuki Toshihiko, Iwanaga Shiroh, Ablordey Anthony, Saito Ryoichi. Possible Dissemination of Escherichia coli Sequence Type 410 Closely Related to B4/H24RxC in Ghana FRONTIERS IN MICROBIOLOGY. 2021.12; 12 770130. ( PubMed, DOI )

  14. Abass Adiza, Okano Tokuju, Boonyaleka Kotchakorn, Kinoshita-Daitoku Ryo, Yamaoka Shoji, Ashida Hiroshi, Suzuki Toshihiko. Effect of low oxygen concentration on activation of inflammation by Helicobacter pylori BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2021.06; 560 179-185. ( PubMed, DOI )

  15. Kinoshita-Daitoku R, Kiga K, Miyakoshi M, Otsubo R, Ogura Y, Sanada T, Bo Z, Phuoc TV, Okano T, Iida T, Yokomori R, Kuroda E, Hirukawa S, Tanaka M, Sood A, Subsomwong P, Ashida H, Binh TT, Nguyen LT, Van KV, Ho DQD, Nakai K, Suzuki T, Yamaoka Y, Hayashi T, Mimuro H. A bacterial small RNA regulates the adaptation of Helicobacter pylori to the host environment. Nature communications. 2021.04; 12 (1): 2085. ( PubMed, DOI )

  16. Prah Isaac, Ayibieke Alafate, Nguyen Thi Thu Huong, Iguchi Atsushi, Mahazu Samiratu, Sato Wakana, Hayashi Takaya, Yamaoka Shoji, Suzuki Toshihiko, Iwanaga Shiroh, Ablordey Anthony, Saito Ryoichi. Virulence Profiles of Diarrheagenic Escherichia coli Isolated from the Western Region of Ghana(和訳中) Japanese Journal of Infectious Diseases. 2021.03; 74 (2): 115-121. ( ichushi )

  17. Okano Tokuju, Suzuki Toshihiko. Inflammasome activation inducer produced by Aggregatibacter actinomycetemcomitans causes arthritis(和訳中) 口腔病学会雑誌. 2021.03; 88 (1): 70-71. ( ichushi )

  18. Kurashima Y, Kigoshi T, Murasaki S, Arai F, Shimada K, Seki N, Kim YG, Hase K, Ohno H, Kawano K, Ashida H, Suzuki T, Morimoto M, Saito Y, Sasou A, Goda Y, Yuki Y, Inagaki Y, Iijima H, Suda W, Hattori M, Kiyono H. Pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation. Nature communications. 2021.02; 12 (1): 1067. ( PubMed, DOI )

  19. Abass Adiza, 鈴木 敏彦. ピロリ菌によって誘導されるインフラマソーム活性化における低酸素環境下での影響(The effect of hypoxia on Helicobacter pylori induced inflammasome activation) 日本細菌学雑誌. 2021.02; 76 (1): 107. ( ichushi )

  20. 岡野 徳壽, 鈴木 敏彦. 低酸素環境と疾患(がん、感染症)の分子論　低酸素環境下においてTRIF-HIF-1α経路はP.gingivalisによるインフラマソーム活性化亢進を制御している(TRIF-HIF-1α signaling under hypoxia drives enhancement of inflammasome activation by P. gingivalis) 日本細菌学雑誌. 2021.02; 76 (1): 57. ( ichushi )

  21. Prah Isaac, Ayibieke Alafate, Mahazu Samiratu, Sassa Chihiro Tani, Hayashi Takaya, Yamaoka Shoji, Suzuki Toshihiko, Iwanaga Shiroh, Ablordey Anthony, Saito Ryoichi. Emergence of oxacillinase-181 carbapenemase-producing diarrheagenic Escherichia coli in Ghana EMERGING MICROBES & INFECTIONS. 2021.01; 10 (1): 865-873. ( PubMed, DOI )

  22. Prah Isaac, Ayibieke Alafate, Mahazu Samiratu, 佐々 千尋, 林 隆也, 鈴木 敏彦, 岩永 史朗, 山岡 昇司, Ablordey Anthony, 齋藤 良一. ガーナから来た下痢患者由来のOXA-181型カルバペネマーゼ産生大腸菌に関する全ゲノム性状分析(Whole-genome characterization of OXA-181 carbapenemase producing Escherichia coli from diarrheic patients in Ghana) 日本臨床微生物学会雑誌. 2020.12; 31 (Suppl.1): 205. ( ichushi )

  23. Ayibieke Alafate, Kobayashi Ayumi, Suzuki Masato, Sato Wakana, Mahazu Samiratu, Prah Isaac, Mizoguchi Miyuki, Moriya Kyoji, Hayashi Takaya, Suzuki Toshihiko, Iwanaga Shiroh, Ablordey Anthony, Saito Ryoichi. Prevalence and Characterization of Carbapenem-Hydrolyzing Class D beta-Lactamase-Producing Acinetobacter Isolates From Ghana FRONTIERS IN MICROBIOLOGY. 2020.11; 11 587398. ( PubMed, DOI )

  24. Prah I, Ayibieke A, Huong NTT, Iguchi A, Mahazu S, Sato W, Hayashi T, Yamaoka S, Suzuki T, Iwanaga S, Ablordey A, Saito R. Virulence profile of diarrhoeagenic Escherichia coli from the Western region of Ghana. Japanese journal of infectious diseases. 2020.08; ( PubMed, DOI )

  25. Ashida H, Suzuki T, Sasakawa C. Shigella infection and host cell death: a double-edged sword for the host and pathogen survival. Current opinion in microbiology. 2020.08; 59 1-7. ( PubMed, DOI )

  26. Ashida H, Sasakawa C, Suzuki T. A unique bacterial tactic to circumvent the cell death crosstalk induced by blockade of caspase-8. The EMBO journal. 2020.07; 39 (17): e104469. ( PubMed, DOI )

  27. Saeki A, Tsuchiya K, Suda T, Into T, Hasebe A, Suzuki T, Shibata KI. Gasdermin D-independent release of interleukin-1b by living macrophages in response to mycoplasmal lipoproteins and lipopeptides. Immunology. 2020.06; ( PubMed, DOI )

  28. Kinoshita-Daitoku R, Kiga K, Sanada T, Ogura Y, Bo Z, Iida T, Yokomori R, Kuroda E, Tanaka M, Sood A, Suzuki T, Nakai K, Hayashi T, Mimuro H. Mutational diversity in mutY deficient Helicobacter pylori and its effect on adaptation to the gastric environment. Biochemical and biophysical research communications. 2020.05; 525 (3): 806-811. ( PubMed, DOI )

  29. Tanaka M, Kinoshita-Daitoku R, Kiga K, Sanada T, Zhu B, Okano T, Aikawa C, Iida T, Ogura Y, Hayashi T, Okubo K, Kurosawa M, Hirahashi J, Suzuki T, Nakagawa I, Nangaku M, Mimuro H. Group A Streptococcus establishes pharynx infection by degrading the deoxyribonucleic acid of neutrophil extracellular traps. Scientific reports. 2020.02; 10 (1): 3251. ( PubMed, DOI )

  30. 岡野 徳壽, 鈴木 敏彦. A. actinomycetemcomitans induces inflammasome activation via lysosomal degradation(和訳中) 日本細菌学雑誌. 2020.01; 75 (1): 90. ( ichushi )

  31. Prah Isaac, Ayibieke Alafate, 井口 純, Mahazu Samiratu, 佐藤 和佳菜, 鈴木 敏彦, 山岡 昇司, 岩永 史朗, Ablordey Anthony, 齋藤 良一. Virulence Profile of Diarrheagenic E. coli from the Western region of Ghana(和訳中) 日本細菌学雑誌. 2020.01; 75 (1): 118. ( ichushi )

  32. Toma C, Suzuki T. Evaluation of Intracellular Trafficking in Macrophages. Methods in molecular biology (Clifton, N.J.). 2020; 2134 199-206. ( PubMed, DOI )

  33. Okano Tokuju, Sasai Miwa, Yamamoto Masahiro, Suzuki Toshihiko. Immunology of infection-2　Aggregatibacter actinomycetemcomitans induces activation of noncanonical inflammasome via lysosomal degradation(和訳中) 日本免疫学会総会・学術集会記録. 2019.11; 48 (Proceedings): 3-C. ( ichushi )

  34. Yamamura Kiyonobu, Ashida Hiroshi, Okano Tokuju, Kinoshita-Daitoku Ryo, Suzuki Shiho, Ohtani Kaori, Hamagaki Miwako, Ikeda Tohru, Suzuki Toshihiko. Inflammasome Activation Induced by Perfringolysin O of Clostridium perfringens and Its Involvement in the Progression of Gas Gangrene FRONTIERS IN MICROBIOLOGY. 2019.10; 10 2406. ( PubMed, DOI )

  35. Leewananthawet Anongwee, Arakawa Shinichi, Okano Tokuju, Kinoshita Ryo Daitoku, Ashida Hiroshi, Izumi Yuichi, Suzuki Toshihiko. Ozone ultrafine bubble water induces the cellular signaling involved in oxidative stress responses in human periodontal ligament fibroblasts SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS. 2019.06; 20 (1): 589-598. ( PubMed, DOI )

  36. Nakamoto Nobuhiro, Sasaki Nobuo, Aoki Ryo, Miyamoto Kentaro, Suda Wataru, Teratani Toshiaki, Suzuki Takahiro, Koda Yuzo, Chu Po-Sung, Taniki Nobuhito, Yamaguchi Akihiro, Kanamori Mitsuhiro, Kamada Nobuhiko, Hattori Masahira, Ashida Hiroshi, Sakamoto Michiie, Atarashi Koji, Narushima Seiko, Yoshimura Akihiko, Honda Kenya, Sato Toshiro, Kanai Takanori. Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis NATURE MICROBIOLOGY. 2019.03; 4 (3): 492-503. ( DOI )

  37. Okano T, Ashida H, Suzuki S, Shoji M, Nakayama K, Suzuki T. Porphyromonas gingivalis triggers NLRP3-mediated inflammasome activation in macrophages in a bacterial gingipains-independent manner. European journal of immunology. 2018.12; 48 (12): 1965-1974. ( PubMed, DOI )

  38. Ayibieke Alafate, Sato Wakana, Mahazu Samiratu, Prah Isaac, Addow-Thompson John, Ohashi Mitsuko, Suzuki Toshihiko, Iwanaga Shiroh, Ablordey Anthony, Saito Ryoichi. Molecular characterisation of the NDM-1-encoding plasmid p2189-NDM in an Escherichia coli ST410 clinical isolate from Ghana PLOS ONE. 2018.12; 13 (12): e0209623. ( PubMed, DOI )

  39. Suzuki Shiho, Suzuki Toshihiko. Cellular inhibitor of apoptosis protein 1 and 2 are important for the Inflammasome activation) Proceedings of The Japanese Society for Immunology . 2018.12; 47 (Proceedings): 1-E. ( ichushi )

  40. Ashida Hiroshi, Suzuki Toshihiko. Bacterial / mycofungal / parasite infection　Analysis of novel Shigella effector mechanism that regulate host cell death Proceedings of The Japanese Society for Immunology . 2018.12; 47 (Proceedings): 3-H. ( ichushi )

  41. Yamaguchi Takayoshi, Higa Naomi, Okura Nobuhiko, Matsumoto Arina, Hermawan Idam, Yamashiro Tetsu, Suzuki Toshihiko, Toma Claudia. Characterizing interactions of Leptospira interrogans with proximal renal tubule epithelial cells BMC MICROBIOLOGY. 2018.07; 18 (1): 64. ( PubMed, DOI )

  42. Nakasone Noboru, Ogura Yasunori, Higa Naomi, Toma Claudia, Koizumi Yukiko, Takaesu Giichi, Suzuki Toshihiko, Yamashiro Tetsu. Effects of Psidium guajava leaf extract on secretion systems of gram-negative enteropathogenic bacteria MICROBIOLOGY AND IMMUNOLOGY. 2018.07; 62 (7): 444-453. ( PubMed, DOI )

  43. Ayumi Saeki, Masahiro Sugiyama, Akira Hasebe, Toshihiko Suzuki, Ken-Ichiro Shibata. Activation of NLRP3 inflammasome in macrophages by mycoplasmal lipoproteins and lipopeptides. Mol Oral Microbiol. 2018.04; ( PubMed, DOI )

  44. Yuhei Maruzuru, Takeshi Ichinohe, Ryota Sato, Kensuke Miyake, Tokuju Okano, Toshihiko Suzuki, Takumi Koshiba, Naoto Koyanagi, Shumpei Tsuda, Mizuki Watanabe, Jun Arii, Akihisa Kato, Yasushi Kawaguchi. Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication. Cell Host Microbe. 2018.02; 23 (2): 254-265.e7. ( PubMed, DOI )

  45. Shiho Suzuki, Toshihiko Suzuki, Hitomi Mimuro, Tsunehiro Mizushima, Chihiro Sasakawa. Shigella hijacks the glomulin-cIAPs-inflammasome axis to promote inflammation. EMBO Rep.. 2018.01; 19 (1): 89-101. ( PubMed, DOI )

  46. Suzuki Shiho, Suzuki Toshihiko. Immune response to bacteial infections The microbial-host interactions that drive the activation of the Nlrc4 inflammasome in Shigella-infected macrophages(和訳中) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): 1-E. ( ichushi )

  47. Suzuki Toshihiko, Kannagi Mari. Pathogen infection and host responses(和訳中) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): OT4. ( ichushi )

  48. Noboru Nakasone, Naomi Higa, Claudia Toma, Yasunori Ogura, Toshihiko Suzuki, Tetsu Yamashiro. Epigallocatechin gallate inhibits the type III secretion system of Gram-negative enteropathogenic bacteria under model conditions. FEMS Microbiol. Lett.. 2017.07; 364 (13): ( PubMed, DOI )

  49. Ayumi Saeki, Toshihiko Suzuki, Akira Hasebe, Ryousuke Kamezaki, Mari Fujita, Futoshi Nakazawa, Ken-Ichiro Shibata. Activation of nucleotide-binding domain-like receptor containing protein 3 inflammasome in dendritic cells and macrophages by Streptococcus sanguinis. Cell. Microbiol.. 2017.03; 19 (3): ( PubMed, DOI )

  50. Hiroshi Ashida, Chihiro Sasakawa. Bacterial E3 ligase effectors exploit host ubiquitin systems. Curr. Opin. Microbiol.. 2017.02; 35 16-22. ( PubMed, DOI )

  51. Toma Claudia, 山口 孝治, 比嘉 直美, 松本 亜里奈, 大倉 信彦, 仲宗根 昇, 鈴木 敏彦, 山城 哲. 感染性のLeptospira interrogansと腎上皮細胞の相互作用(Interaction of virulent Leptospira interrogans with renal epithelial cells) 日本細菌学雑誌. 2017.02; 72 (1): 124. ( ichushi )

  52. Yohei Yamaguchi, Tomoko Kurita-Ochiai, Ryoki Kobayashi, Toshihiko Suzuki, Tomohiro Ando. Regulation of the NLRP3 inflammasome in Porphyromonas gingivalis-accelerated periodontal disease. Inflamm. Res.. 2017.01; 66 (1): 59-65. ( PubMed, DOI )

  53. Noboru Nakasone, Yasunori Ogura, Naomi Higa, Claudia Toma, Yukiko Koizumi, Toshihiko Suzuki, Tetsu Yamashiro. Hot-PBS extract of Vibrio vulnificus induces NF-kB activation Electronic J. Biol.. 2017;

  54. M Sugiyama, A Saeki, A Hasebe, R Kamesaki, Y Yoshida, Y Kitagawa, T Suzuki, K Shibata. Activation of inflammasomes in dendritic cells and macrophages by Mycoplasma salivarium. Mol Oral Microbiol. 2015.07; ( PubMed, DOI )

  55. Yohei Yamaguchi, Tomoko Kurita-Ochiai, Ryoki Kobayashi, Toshihiko Suzuki, Tomohiro Ando. Activation of the NLRP3 inflammasome in Porphyromonas gingivalis-accelerated atherosclerosis. Pathog Dis. 2015.06; 73 (4): ( PubMed, DOI )

  56. Kazuhito Satou, Makiko Shimoji, Hinako Tamotsu, Ayaka Juan, Noriko Ashimine, Misuzu Shinzato, Claudia Toma, Toshitsugu Nohara, Akino Shiroma, Kazuma Nakano, Kuniko Teruya, Yasunobu Terabayashi, Shun Ohki, Nobuo Koizumi, Shou Okano, Toshihiko Suzuki, Takashi Hirano. Complete Genome Sequences of Low-Passage Virulent and High-Passage Avirulent Variants of Pathogenic Leptospira interrogans Serovar Manilae Strain UP-MMC-NIID, Originally Isolated from a Patient with Severe Leptospirosis, Determined Using PacBio Single-Molecule Real-Time Technology. Genome Announc. 2015; 3 (4): ( PubMed, DOI )

  57. Shiho Suzuki, Hitomi Mimuro, Minsoo Kim, Michinaga Ogawa, Hiroshi Ashida, Takahito Toyotome, Luigi Franchi, Masato Suzuki, Takahito Sanada, Toshihiko Suzuki, Hiroko Tsutsui, Gabriel Núñez, Chihiro Sasakawa. Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages. Proc. Natl. Acad. Sci. U.S.A.. 2014.10; 111 (40): E4254-E4263. ( PubMed, DOI )

  58. Ryota Itoh, Issaku Murakami, Bin Chou, Kazunari Ishii, Toshinori Soejima, Toshihiko Suzuki, Kenji Hiromatsu. Chlamydia pneumoniae harness host NLRP3 inflammasome-mediated caspase-1 activation for optimal intracellular growth in murine macrophages. Biochem. Biophys. Res. Commun.. 2014.09; 452 (3): 689-694. ( PubMed, DOI )

  59. Claudia Toma, Gerald L Murray, Toshitsugu Nohara, Masaru Mizuyama, Nobuo Koizumi, Ben Adler, Toshihiko Suzuki. Leptospiral outer membrane protein LMB216 is involved in enhancement of phagocytic uptake by macrophages. Cell. Microbiol.. 2014.09; 16 (9): 1366-1377. ( PubMed, DOI )

  60. Ting Liu, Yoshifumi Yamaguchi, Yoshitaka Shirasaki, Koichi Shikada, Mai Yamagishi, Katsuaki Hoshino, Tsuneyasu Kaisho, Kiwamu Takemoto, Toshihiko Suzuki, Erina Kuranaga, Osamu Ohara, Masayuki Miura. Single-cell imaging of caspase-1 dynamics reveals an all-or-none inflammasome signaling response. Cell Rep. 2014.08; 8 (4): 974-982. ( PubMed, DOI )

  61. Amy M King, Gabriela Pretre, Thanatchaporn Bartpho, Rasana W Sermswan, Claudia Toma, Toshihiko Suzuki, Azad Eshghi, Mathieu Picardeau, Ben Adler, Gerald L Murray. High-temperature protein G is an essential virulence factor of Leptospira interrogans. Infect. Immun.. 2014.03; 82 (3): 1123-1131. ( PubMed, DOI )

  62. Shiho Suzuki, Luigi Franchi, Yuan He, Raul Muñoz-Planillo, Hitomi Mimuro, Toshihiko Suzuki, Chihiro Sasakawa, Gabriel Núñez. Shigella type III secretion protein MxiI is recognized by Naip2 to induce Nlrc4 inflammasome activation independently of Pkcδ. PLoS Pathog.. 2014.02; 10 (2): e1003926. ( PubMed, DOI )

  63. Naomi Higa, Claudia Toma, Toshitsugu Nohara, Noboru Nakasone, Giichi Takaesu, Toshihiko Suzuki. Lose the battle to win the war: bacterial strategies for evading host inflammasome activation. Trends Microbiol.. 2013.07; 21 (7): 342-349. ( PubMed, DOI )

  64. Naomi Higa, Claudia Toma, Yukiko Koizumi, Noboru Nakasone, Toshitsugu Nohara, Junya Masumoto, Toshio Kodama, Tetsuya Iida, Toshihiko Suzuki. Vibrio parahaemolyticus effector proteins suppress inflammasome activation by interfering with host autophagy signaling. PLoS Pathog.. 2013.01; 9 (1): e1003142. ( PubMed, DOI )

  65. Yukiko Koizumi, Claudia Toma, Naomi Higa, Toshitsugu Nohara, Noboru Nakasone, Toshihiko Suzuki. Inflammasome activation via intracellular NLRs triggered by bacterial infection. Cell. Microbiol.. 2012.02; 14 (2): 149-154. ( PubMed, DOI )

  66. Hiroshi Ashida, Michinaga Ogawa, Minsoo Kim, Shiho Suzuki, Takahito Sanada, Claire Punginelli, Hitomi Mimuro, Chihiro Sasakawa. Shigella deploy multiple countermeasures against host innate immune responses. Curr. Opin. Microbiol.. 2011.02; 14 (1): 16-23. ( PubMed, DOI )

  67. Andrea J McCoy, Yukiko Koizumi, Naomi Higa, Toshihiko Suzuki. Differential regulation of caspase-1 activation via NLRP3/NLRC4 inflammasomes mediated by aerolysin and type III secretion system during Aeromonas veronii infection. J. Immunol.. 2010.12; 185 (11): 7077-7084. ( PubMed, DOI )

  68. Andrea J McCoy, Yukiko Koizumi, Claudia Toma, Naomi Higa, Vishva Dixit, Shun'ichiro Taniguchi, Jürg Tschopp, Toshihiko Suzuki. Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase-1 activation in macrophages. Eur. J. Immunol.. 2010.10; 40 (10): 2797-2803. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Hsu Chenwei, 岡野 徳壽, 鈴木 敏彦. Tannerella forsythia induces inflammasome activation by triggering both NLRP3 and Caspase-4(タイトル和訳中). 日本細菌学雑誌 2024.06.01

  2. Chenwei Hsu, 岡野 徳壽, 鈴木 敏彦. Tannerella forsythiaはNLRP3とカスパーゼ4の両者のトリガーとなることでインフラマソーム活性化を誘導する(Tannerella forsythia induces inflammasome activation by triggering both NLRP3 and Caspase-4). 口腔病学会雑誌 2024.03.01

  3. Chenwei Hsu, 岡野 徳壽, 鈴木 敏彦. Tannerella forsythia induces inflammasome activation by triggering both NLRP3 and Caspase-4(タイトル和訳中). 口腔病学会雑誌 2024.03.01

  4. Chenwei Hsu, Tokuju Okano, Toshihiko Suzuki. Tannerella forsythia induces inflammasome activation by triggering both NLRP3 and Caspase-4. 第52回日本免疫学会学術集会 2024.01.17 千葉

  5. Toshihiko Suzuki. Advanced collaborative research in infectious diseases in Ghana. Annual Research Meeting 2023 in Noguchi Memorial Institute for Medical Research 2023.11.24 Accra

  6. Kotchakorn Boonyaleka, Okano Tokuju, Suzuki Toshihiko. 急性結腸炎のマウスにおいてFusobacterium nucleatumの感染は非正規のインフラマソーム経路を活性化して炎症反応を増悪化させる. 第87回口腔病学会学術集会 2022.12.03

  7. Toshihiko Suzuki. Advanced collaborative research in infectious diseases in Ghana. Africa Symposium 2022 2022.12.02 Kisumu, Kenya

  8. Mahazu Samiratu, Prah Isaac, Ota Yusuke, Hayashi Takaya, Nukui Yoko, Suzuki Masato, Hoshino Yoshihiko, Akeda Yukihiro, Suzuki Toshihiko, Ishino Tomoko, Ablordey Anthony, Saito Ryoichi. Genetic analysis of carbapenemase-producing Enterobacter cloacae and Klebsiella species. Annual meeting of the Japanese Society for Clinical Microbiology 2022.12.01

  9. Okano Tokuju, Suzuki Toshihiko. Infection and Immunity I(Porphyromnas gingivalis infection triggers enhancement of severity for EAE following inflammasome activation in macrophages). 日本免疫学会総会・学術集会記録 2022.11.01

  10. Boonyaleka Kotchakorn, Okano Tokuju, Suzuki Toshihiko. Innate immunity(1) Innate inflammation and disease(Fusobacterium nucleatum infection activates the non-canonical inflammasome pathway to exacerbate inflammatory response in acute colitis mice). 日本免疫学会総会・学術集会記録 2022.11.01

  11. Okano Tokuju, Suzuki Toshihiko. Aggregatibacter actinomycetemcomitansが産生するインフラマソーム活性化誘導因子は関節炎の原因となる(Inflammasome activation inducer produced by Aggregatibacter actinomycetemcomitans causes arthritis). 口腔病学会雑誌 2021.03.01

  12. Okano Tokuju, Suzuki Toshihiko. Aggregatibacter actinomycetemcomitansが産生するインフラマソーム活性化誘導因子は関節炎の原因となる(Inflammasome activation inducer produced by Aggregatibacter actinomycetemcomitans causes arthritis). 口腔病学会雑誌 2021.03.01

  13. Adiza Abass, Toshihiko Suzuki. The effect of hypoxia on Helicobacter pylori induced inflammasome activation. 第76回日本細菌学会総会 2021.02

  14. 岡野 徳壽, 鈴木 敏彦. A.actinomycetemcomitansはリソソーム分解を介してインフラマソーム活性化を誘発する(A. actinomycetemcomitans induces inflammasome activation via lysosomal degradation). 日本細菌学雑誌 2020.01.01

  15. Prah Isaac, Ayibieke Alafate, 井口 純, Mahazu Samiratu, 佐藤 和佳菜, 鈴木 敏彦, 山岡 昇司, 岩永 史朗, Ablordey Anthony, 齋藤 良一. ガーナ西地区で分離された下痢誘発性大腸菌の毒性の特徴(Virulence Profile of Diarrheagenic E. coli from the Western region of Ghana). 日本細菌学雑誌 2020.01.01

  16. 岡野 徳壽, 鈴木 敏彦. A.actinomycetemcomitansはリソソーム分解を介してインフラマソーム活性化を誘発する(A. actinomycetemcomitans induces inflammasome activation via lysosomal degradation). 日本細菌学雑誌 2020.01.01

  17. Prah Isaac, Ayibieke Alafate, 井口 純, Mahazu Samiratu, 佐藤 和佳菜, 鈴木 敏彦, 山岡 昇司, 岩永 史朗, Ablordey Anthony, 齋藤 良一. ガーナ西地区で分離された下痢誘発性大腸菌の毒性の特徴(Virulence Profile of Diarrheagenic E. coli from the Western region of Ghana). 日本細菌学雑誌 2020.01.01

  18. Tokuju Okano, Miwa Sasai, Masahiro Yamamoto, Toshihiko Suzuki. Aggregatibacter actinomycetemcomitans induces activation of noncanonical inflammasome via lysosomal degradation. The 48th annual meeting of the Japanese Society for Immunology 2019.12.13 Hamamatsu

  19. Okano Tokuju, Sasai Miwa, Yamamoto Masahiro, Suzuki Toshihiko. 感染症の免疫学　Aggregatibacter actinomycetemcomitansはリソソーム性分解を介して非標準的インフラマソーム活性化を誘導する(Immunology of infection-2　Aggregatibacter actinomycetemcomitans induces activation of noncanonical inflammasome via lysosomal degradation). 日本免疫学会総会・学術集会記録 2019.11.01

  20. Okano Tokuju, Sasai Miwa, Yamamoto Masahiro, Suzuki Toshihiko. 感染症の免疫学　Aggregatibacter actinomycetemcomitansはリソソーム性分解を介して非標準的インフラマソーム活性化を誘導する(Immunology of infection-2　Aggregatibacter actinomycetemcomitans induces activation of noncanonical inflammasome via lysosomal degradation). 日本免疫学会総会・学術集会記録 2019.11.01

  21. Okano Tokuju, Suzuki Toshihiko. Hypoxia induces enhancement of inflammasome activation by P. gingivalis. 7th International Cytokine and Interferon Society 2019.10.20 Vienna

  22. Ashida Hiroshi, Suzuki Toshihiko. Analysis of novel Shigella effector mechanism that regulate host cell death. The 47th Annual meeting of the Japanese Society for Immunology 2018.12.10 Fukuoka

  23. Suzuki Shiho, Suzuki Toshihiko. Cellular inhibitor of apoptosis protein 1 and 2 are important for the Inflammasome activation. he 47th Annual meeting of the Japanese Society for Immunology 2018.12.10 Fukuoka

  24. Leewananthawet Anongwee, Arakawa Shinichi, Okano Tokuju, Ashida Hiroshi, Izumi Yuichi, Suzuki Toshihiko. in vitroにおけるオゾン微細泡の生物学的影響の評価(Evaluation the biological effects of Ozone Ultrafine-Bubble Water in vitro). 日本歯周病学会会誌 2018.05.01

  25. Shiho Suzuki, Toshihiko Suzuki, Hitomi Mimuro, Chihiro Sasakawa. IAP family members are involved in inflammasome activation in response to bacterial infection. The 91st Annual Meeting of Japanese Society for Bacteriology 2018.03.27 Fukuoka

  26. 佐伯 歩, 長谷部 晃, 鈴木 敏彦, 柴田 健一郎. NLRP3 inflammasome活性化のためのマイコプラズマリポペプチドFSL-1の細胞質ゾルへの移行(Translocation of mycoplasmal lipopeptide FSL-1 into cytosol for the NLRP3 inflammasome activation). 日本細菌学雑誌 2018.02.01

  27. 鈴木 志穂, 鈴木 敏彦, 三室 仁美, 笹川 千尋. IAP familyは細菌感染によるinflammasome活性化に関与する(IAP family members are involved in inflammasome activation in response to bacterial infection). 日本細菌学雑誌 2018.02.01

  28. Shiho Suzuki, Toshihiko Suzuki. The microbial-host interaction that drive the activation of the Nlrc4 inflammasome in Shigella-infected macrophages. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.12 Sendai

  29. Toshihiko Suzuki. Pathogen infection and host responses. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.12 Sendai

  30. Suzuki Toshihiko, Kannagi Mari. 病原体感染と宿主応答(Pathogen infection and host responses). 日本免疫学会総会・学術集会記録 2017.12.01

  31. Suzuki Shiho, Suzuki Toshihiko. 細菌感染に対する免疫応答　赤痢菌感染マクロファージにおいてNlrc4 inflammasomeの活性化を促進する菌宿主相互作用(Immune response to bacteial infections　The microbial-host interactions that drive the activation of the Nlrc4 inflammasome in Shigella-infected macrophages). 日本免疫学会総会・学術集会記録 2017.12.01

  32. Suzuki Toshihiko, Kannagi Mari. 病原体感染と宿主応答(Pathogen infection and host responses). 日本免疫学会総会・学術集会記録 2017.12.01

  33. Suzuki Shiho, Suzuki Toshihiko. 細菌感染に対する免疫応答　赤痢菌感染マクロファージにおいてNlrc4 inflammasomeの活性化を促進する菌宿主相互作用(Immune response to bacteial infections　The microbial-host interactions that drive the activation of the Nlrc4 inflammasome in Shigella-infected macrophages). 日本免疫学会総会・学術集会記録 2017.12.01

  34. Claudia Toma, Takayoshi Yamaguchi, Naomi Higa, Arina Matsumoto, Nobuhiko Okura, Noboru Nakasone, Toshihiko Suzuki, Tetsu Yamashiro. Interaction of virulent Leptospira interrogans with renal epithelial cells. The 90th Annual Meeting of Japanese Society for Bacteriology 2017.03.20 Sendai

  35. Toma Claudia, 山口 孝治, 比嘉 直美, 松本 亜里奈, 大倉 信彦, 仲宗根 昇, 鈴木 敏彦, 山城 哲. 感染性のLeptospira interrogansと腎上皮細胞の相互作用(Interaction of virulent Leptospira interrogans with renal epithelial cells). 日本細菌学雑誌 2017.02.01

  36. Giichi Takaesu, Noboru Nakasone, Claudia Toma, Naomi Higa, Toshihiko Suzuki. TAK1-binding protein 2 (TAB2) negatively regulates the processing of pro-interleukin-1beta. The 44th Annual Meeting of The Japanese Society for Immunology 2015.11.18 Sapporo

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