Personnel Information

写真a

YAMASHITA Motoi


Job title

Visiting Lecturer

Graduating School 【 display / non-display

  • Tokyo Medical and Dental University, Faculty of Medicine, 2010.03, Graduated

Graduate School 【 display / non-display

  • Tokyo Medical and Dental University, Doctor's Course, 2019.03, Completed

Campus Career 【 display / non-display

  • 2014.04
    -
    2019.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Environmental Response, Pediatrics and Developmental Biology, Graduate Student
  • 2019.04
    -
    2020.05
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Endowed Departments, Department of Child Health and Development, Assistant Professor
  • 2019.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Environmental Response, Pediatrics and Developmental Biology, Assistant Professor
  • 2020.06
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    2021.09
    Tokyo Medical and Dental University, Medical Hospital, Hospital Departments, Department of Pediatrics, Maternal and Woman's Medicine, Pediatrics, Assistant Professor
  • 2021.10
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    2022.03
    Tokyo Medical and Dental University, Tokyo Medical and Dental University, Division of Clinical Medicine, Department of Pediatrics, Perinatal, and Women's Medicine, Pediatrics, Assistant Professor
  • 2022.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, -, -, Visiting Lecturer

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Published Papers & Misc 【 display / non-display

  1. Yamaguchi Y, Takasawa K, Irabu H, Hiratoko K, Ichigi Y, Hirata K, Tamura Y, Murakoshi M, Yamashita M, Nakatani H, Shimoda M, Ishii T, Udagawa T, Shimizu M, Kanegane H, Morio T. Infliximab treatment for refractory COVID-19-associated multisystem inflammatory syndrome in a Japanese child. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2022.01; ( PubMed, DOI )

  2. Yeh Tzu-Wen, Okano Tsubasa, Naruto Takuya, Yamashita Motoi, Okamura Miko, Tanita Kay, Du Likun, Pan-Hammarstrom Qiang, Mitsuiki Noriko, Okada Satoshi, Kanegane Hirokazu, Imai Kohsuke, Morio Tomohiro. APRIL-dependent lifelong plasmacyte maintenance and immunoglobulin production in humans JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2020.11; 146 (5): 1109-+. ( PubMed, DOI )

  3. Inoue Maiko, Isoda Takeshi, Yamashita Motoi, Tomoda Takahiro, Inoue Kento, Okano Tsubasa, Ohkawa Teppei, Endo Akifumi, Mitsuiki Noriko, Kamiya Takahiro, Yanagimachi Masakatsu, Yamamoto Kouhei, Inaba Yuichiro, Sasaki Toru, Takagi Masatoshi, Kanegane Hirokazu, Imai Kohsuke, Morio Tomohiro. Cytomegalovirus Laryngitis in Primary Combined Immunodeficiency Diseases JOURNAL OF CLINICAL IMMUNOLOGY. 2020.10; 41 (1): 243-247. ( PubMed, DOI )

  4. Okano Tsubasa, Imai Kohsuke, Naruto Takuya, Okada Satoshi, Yamashita Motoi, Yeh Tzu-wen, Ono Shintaro, Tanaka Keisuke, Okamoto Keisuke, Tanita Kay, Matsumoto Kazuaki, Toyofuku Etsushi, Kumaki-Matsumoto Eri, Okamura Miko, Ueno Hiroo, Ogawa Seishi, Ohara Osamu, Takagi Masatoshi, Kanegane Hirokazu, Morio Tomohiro. Whole-Exome Sequencing-Based Approach for Germline Mutations in Patients with Inborn Errors of Immunity JOURNAL OF CLINICAL IMMUNOLOGY. 2020.07; 40 (5): 729-740. ( PubMed, DOI )

  5. Yamashita Motoi, Wakatsuki Ryosuke, Kato Tamaki, Okano Tsubasa, Yamanishi Shingo, Mayumi Nobuko, Tanaka Mayuri, Ogura Yumi, Kanegane Hirokazu, Nonoyama Shigeaki, Imai Kohsuke, Morio Tomohiro. A synonymous splice site mutation in IL2RG gene causes late-onset combined immunodeficiency INTERNATIONAL JOURNAL OF HEMATOLOGY. 2019.05; 109 (5): 603-611. ( PubMed, DOI )

  6. Miyamoto C, Kojo S, Yamashita M, Moro K, Lacaud G, Shiroguchi K, Taniuchi I, Ebihara T. Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation. Nature communications. 2019.01; 10 (1): 447. ( PubMed, DOI )

  7. Ono S, Nakayama M, Kanegane H, Hoshino A, Shimodera S, Shibata H, Fujino H, Fujino T, Yunomae Y, Okano T, Yamashita M, Yasumi T, Izawa K, Takagi M, Imai K, Zhang K, Marsh R, Picard C, Latour S, Ohara O, Morio T. Comprehensive molecular diagnosis of Epstein-Barr virus-associated lymphoproliferative diseases using next-generation sequencing. International journal of hematology. 2018.09; 108 (3): 319-328. ( PubMed, DOI )

  8. Hoshino Akihiro, Takashima Takehiro, Yoshida Kenichi, Morimoto Akira, Kawahara Yuta, Yeh Tzu-Wen, Okano Tsubasa, Yamashita Motoi, Mitsuiki Noriko, Imai Kohsuke, Sakatani Takashi, Nakazawa Atsuko, Okuno Yusuke, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Miyano Satoru, Ogawa Seishi, Kojima Seiji, Morio Tomohiro, Kanegane Hirokazu. Dysregulation of Epstein-Barr Virus Infection in Hypomorphic ZAP70 Mutation JOURNAL OF INFECTIOUS DISEASES. 2018.09; 218 (5): 825-834. ( PubMed, DOI )

  9. Okano Tsubasa, Tsujita Yuki, Kanegane Hirokazu, Mitsui-Sekinaka Kanako, Tanita Kay, Miyamoto Satoshi, Yeh Tzu-Wen, Yamashita Motoi, Terada Naomi, Ogura Yumi, Takagi Masatoshi, Imai Kohsuke, Nonoyama Shigeaki, Morio Tomohiro. Droplet Digital PCR-Based Chimerism Analysis for Primary Immunodeficiency Diseases JOURNAL OF CLINICAL IMMUNOLOGY. 2018.04; 38 (3): 300-306. ( PubMed, DOI )

  10. Takagi Masatoshi, Hoshino Akihiro, Yoshida Kenichi, Ueno Hiroo, Imai Kohsuke, Piao Jinhua, Kanegane Hirokazu, Yamashita Motoi, Okano Tsubasa, Muramatsu Hideki, Okuno Yusuke, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Miyano Satoru, Ogawa Seishi, Hayashi Yasuhide, Kojima Seiji, Morio Tomohiro. Genetic heterogeneity of uncharacterized childhood autoimmune diseases with lymphoproliferation Pediatr Blood Cancer. 2018.02; 65 (2): e26831.

  11. Kanegane Hirokazu, Hoshino Akihiro, Okano Tsubasa, Yasumi Takahiro, Wada Taizo, Takada Hidetoshi, Okada Satoshi, Yamashita Motoi, Yeh Tzu-wen, Nishikomori Ryuta, Takagi Masatoshi, Imai Kohsuke, Ochs Hans D., Morio Tomohiro. Flow cytometry-based diagnosis of primary immunodeficiency diseases ALLERGOLOGY INTERNATIONAL. 2018.01; 67 (1): 43-54. ( PubMed, DOI )

  12. Okano Tsubasa, Nishikawa Takuro, Watanabe Eri, Watanabe Takashi, Takashima Takehiro, Yeh Tzu-Wen, Yamashita Motoi, Tanaka-Kubota Mari, Miyamoto Satoshi, Mitsuiki Noriko, Takagi Masatoshi, Kawano Yoshifumi, Mochizuki Yoshiki, Imai Kohsuke, Kanegane Hirokazu, Morio Tomohiro. Maternal T and B cell engraftment in two cases of X-linked severe combined immunodeficiency with IgG1 gammopathy CLINICAL IMMUNOLOGY. 2017.10; 183 112-120. ( PubMed, DOI )

  13. Hoshino Akihiro, Okada Satoshi, Yoshida Kenichi, Nishida Naonori, Okuno Yusuke, Ueno Hiroo, Yamashita Motoi, Okano Tsubasa, Tsumura Miyuki, Nishimura Shiho, Sakata Sonoko, Kobayashi Masao, Nakamura Haruna, Kamizono Junji, Mitsui-Sekinaka Kanako, Ichimura Takuya, Ohga Shouichi, Nakazawa Yozo, Takagi Masatoshi, Imai Kohsuke, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Miyano Satoru, Ogawa Seishi, Kojima Seiji, Nonoyama Shigeaki, Morio Tomohiro, Kanegane Hirokazu. Abnormal hematopoiesis and autoimmunity in human subjects with germline IKZF1 mutations JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017.07; 140 (1): 223-231. ( PubMed, DOI )

  14. Takashima Takehiro, Okamura Miko, Yeh Tzu-wen, Okano Tsubasa, Yamashita Motoi, Tanaka Keisuke, Hoshino Akihiro, Mitsuiki Noriko, Takagi Masatoshi, Ishii Eiichi, Imai Kohsuke, Kanegane Hirokazu, Morio Tomohiro. Multicolor Flow Cytometry for the Diagnosis of Primary Immunodeficiency Diseases JOURNAL OF CLINICAL IMMUNOLOGY. 2017.07; 37 (5): 486-495. ( PubMed, DOI )

  15. Takagi Masatoshi, Ogata Shohei, Ueno Hiroo, Yoshida Kenichi, Yeh Tzuwen, Hoshino Akihiro, Piao Jinhua, Yamashita Motoy, Nanya Mai, Okano Tsubasa, Kajiwara Michiko, Kanegane Hirokazu, Muramatsu Hideki, Okuno Yusuke, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Bando Yuki, Kato Motohiro, Hayashi Yasuhide, Miyano Satoru, Imai Kohsuke, Ogawa Seishi, Kojima Seiji, Morio Tomohiro. Haploinsufficiency of TNFAIP3 (A20) by germline mutation is involved in autoimmune lymphoproliferative syndrome JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017.06; 139 (6): 1914-1922. ( DOI )

  16. Sato Takeshi, Okano Tsubasa, Tanaka-Kubota Mari, Kimura Shunsuke, Miyamoto Satoshi, Ono Shintaro, Yamashita Motoi, Mitsuiki Noriko, Takagi Masatoshi, Imai Kohsuke, Kajiwara Michiko, Ebato Takasuke, Ogata Shohei, Oda Hirotsugu, Ohara Osamu, Kanegane Hirokazu, Morio Tomohiro. Novel compound heterozygous mutations in a Japanese girl with Janus kinase 3 deficiency PEDIATRICS INTERNATIONAL. 2016.10; 58 (10): 1076-1080. ( PubMed, DOI )

  17. Elkaim Elodie, Neven Benedicte, Bruneau Julie, Mitsui-Sekinaka Kanako, Stanislas Aurelie, Heurtier Lucie, Lucas Carrie L., Matthews Helen, Deau Marie-Celine, Sharapova Svetlana, Curtis James, Reichenbach Janine, Glastre Catherine, Parry David A., Arumugakani Gururaj, McDermott Elizabeth, Kilic Sara Sebnem, Yamashita Motoi, Moshous Despina, Lamrini Hicham, Otremba Burkhard, Gennery Andrew, Coulter Tanya, Quinti Isabella, Stephan Jean-Louis, Lougaris Vassilios, Brodszki Nicholas, Barlogis Vincent, Asano Takaki, Galicier Lionel, Boutboul David, Nonoyama Shigeaki, Cant Andrew, Imai Kohsuke, Picard Capucine, Nejentsev Sergey, Molina Thierry Jo, Lenardo Michael, Savic Sinisa, Cavazzana Marina, Fischer Alain, Durandy Anne, Kracker Sven. Clinical and immunologic phenotype associated with activated phosphoinositide 3-kinase delta syndrome 2: A cohort study JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2016.07; 138 (1): 210-+. ( PubMed, DOI )

  18. Ikegame Kazuhiro, Imai Kohsuke, Yamashita Motoi, Hoshino Akihiro, Kanegane Hirokazu, Morio Tomohiro, Kaida Katsuji, Inoue Takayuki, Soma Toshihiro, Tamaki Hiroya, Okada Masaya, Ogawa Hiroyasu. Allogeneic stem cell transplantation for X-linked agammaglobulinemia using reduced intensity conditioning as a model of the reconstitution of humoral immunity JOURNAL OF HEMATOLOGY & ONCOLOGY. 2016.02; 9 (1): 9. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  1. Takahiro Tomoda, Tsubasa Okano, Kento Inoue, Motoi Yamashita, Takahiro Kamiya, Takeshi Isoda Masakatsu Yanagimachi, Hirokazu Kanegane, Masatoshi Takagi, Tomohiro Morio, Kohsuke Imai. Second transplantation rescued the graft failure after hematopoietic stem cell transplantation. 3rd Scientific Congress of Asia Pacific Society for Immunodeficiencies 2020.02.09 Chandigarh, India.

  2. Okano T, Imai K, Naruto T, Okada S, Okamoto K, Yamashita M, Yeh T. W, Takagi M, Kanegane H, Morio T. Diagnostic Approach by Whole Exome Sequencing for 141 Patients of Inborn Errors of Immunity. 2019 Focused Meeting of the European Society of Immunodeficiencies 2019.10.18 Brussels, Belgium

  3. Tzu-wen Yeh, Okano T, Okamoto K, Yamashita M, Takashima T, Mitsuiki N, Okada S, Kanegane H, Imai K, Morio T. APRIL deficiency as a cause of common variable immunodeficiency. 第47回日本免疫学会総会学術集会 2018.12.12 福岡

  4. Yeh T. W, Okano T, Okamoto K, Yamashita M, Takashima T, Mitsuki N, Okada S, Kanegane H, Imai K, Morio T. April Deficiency as a Cause of Common Variable Immunodeficiency. 18th Biennial Meeting of the European Society of Immunodeficiencies 2018.10.25 Lisbon

  5. Okamoto K, Shigemizu D, Okano T, Yeh TW, Takashima T, Yamashita M, Ono S, Mitsuiki N, Takagi M, Mori M, Kanegane H, Tsunoda T, Imai K, Morio T. Whole exome sequence analysis using the known and candidate genes for primary immunodeficiency diseases. The 2nd APSID Scientific Congress 2018.05.07 Chonquing, China

  6. Motoi Yamashita. B cell differentiation defect caused by IKZF3 mutation. 第46回日本免疫学会学術集会 2017.12.12 仙台

  7. Motoi Yamashita, Noriko Mitsuiki, Yuzaburo Inoue, Satoshi Okada, Aditya K. Padhi, Kam Y. Zhang, Osamu Ohara, Ichiro Taniuchi, Tomohiro Morio. Heterozygous IKZF3 Mutation in Patients with B cell Deficiency. ESID 2017 2017.09.14

  8. Okano T, Watanabe E, Takashima T, Nishikawa T, Kawano Y, Tomoda T, Tanaka-Kubota M, Miyamoto S, Yeh T, Yamashita M, Tanaka K, Mitusiki N, Ohara O, Takagi M, Imai K, Kanegane H, Morio T. IGG1 Gammopathy in X-SCID Caused by Maternal T and B cell Engraftment. 17th Biennial Meeting of the European Society for Immunodeficiencies 2016.09.23 Barcelona, Spain

  9. Hoshino A, Okada S, Yoshida K, Nishida N, Yamashita M, Okano T, Tsumura M, Nishimura S, Sakata S, Takagi M, Imai K, Miyano S, Ogawa S, Kojima S, Nonoyama S, Morio T, Kanegane H. . Abnormal Hematopoiesis and Autoimmunity in Humans with Germline IKZF1 Mutations. 17th Biennial Meeting of the European Society for Immunodeficiencies 2016.09.22 Barcelona, Spain

  10. Motoi Yamashita, Kohsuke Imai, Tamaki Kato, Shingo Yamanishi, Nobuko Mayumi, Mayuri Tanaka, Tsubasa Okano, Keisuke Tanaka, Tzuwen Yeh, Akihiro Hoshino, Hirokazu Kanegane, Shigeaki Nonoyama, Tomohiro Morio. A novel synonymous mutation in the IL2RG gene results in abnormal splicing, leading to γc deficiency in 16-year-old boy with diffuse warts: a case report. Asia Pacific Society for Immunodeficiencies Congress 2016.04 Hong Kong, China

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