Personnel Information

写真a

CHIBA Tomoki


Job title

Assistant Professor
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Campus Career 【 display / non-display 】

  • 2013.04
    -
    2016.02
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Advanced Therapeutic Sciences， Systems BioMedicine， Project Researcher
  • 2014.04
    -
    2016.04
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Advanced Therapeutic Sciences， Systems BioMedicine， Assistant Professor
  • 2016.05
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    2018.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Advanced Therapeutic Sciences， Systems BioMedicine， Assistant Professor
  • 2018.04
    -
    2020.05
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Advanced Therapeutic Sciences， Systems BioMedicine， Assistant Professor
  • 2020.06
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Advanced Therapeutic Sciences， Systems BioMedicine， Assistant Professor
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Research Areas 【 display / non-display 】

  • Molecular biology

  • Immunology

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Published Papers & Misc 【 display / non-display 】

  1. Lisa Yagasaki, Tomoki Chiba, Ryota Kurimoto, Mitsuyo Nakajima, Takanori Iwata, Hiroshi Asahara. in periodontal ligament on the metabolism of alveolar bone and cementum. Regen Ther. 2024.03; 25 186-193. ( PubMed, DOI )

  2. Mengjiao Li, Tatsunori Nishimura, Yasuto Takeuchi, Tsunaki Hongu, Yuming Wang, Daisuke Shiokawa, Kang Wang, Haruka Hirose, Asako Sasahara, Masao Yano, Satoko Ishikawa, Masafumi Inokuchi, Tetsuo Ota, Masahiko Tanabe, Kei-Ichiro Tada, Tetsu Akiyama, Xi Cheng, Chia-Chi Liu, Toshinari Yamashita, Sumio Sugano, Yutaro Uchida, Tomoki Chiba, Hiroshi Asahara, Masahiro Nakagawa, Shinya Sato, Yohei Miyagi, Teppei Shimamura, Luis Augusto E Nagai, Akinori Kanai, Manami Katoh, Seitaro Nomura, Ryuichiro Nakato, Yutaka Suzuki, Arinobu Tojo, Dominic C Voon, Seishi Ogawa, Koji Okamoto, Theodoros Foukakis, Noriko Gotoh. FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters. J Clin Invest. 2023.11; 133 (22): ( PubMed, DOI )

  3. Maiko Inotsume, Tomoki Chiba, Takahide Matsushima, Ryota Kurimoto, Mitsuyo Nakajima, Tomomi Kato, Kana Shishido, Lin Liu, Koichi Kawakami, Hiroshi Asahara. One-step generation of mice with gene editing by Tol2 transposon-dependent gRNA delivery. FEBS Lett. 2023.03; ( PubMed, DOI )

  4. Hiroto Yamamoto, Yutaro Uchida, Ryota Kurimoto, Tomoki Chiba, Takahide Matsushima, Yoshiaki Ito, Maiko Inotsume, Kohei Miyata, Kenta Watanabe, Masaki Inada, Naoki Goshima, Tokujiro Uchida, Hiroshi Asahara. RNA-binding protein LIN28A upregulates transcription factor HIF1α by posttranscriptional regulation via direct binding to UGAU motifs. J Biol Chem. 2023.01; 299 (1): 102791. ( PubMed, DOI )

  5. Ryo Nakamichi, Shang Ma, Takayuki Nonoyama, Tomoki Chiba, Ryota Kurimoto, Hiroki Ohzono, Merissa Olmer, Chisa Shukunami, Noriyuki Fuku, Guan Wang, Errol Morrison, Yannis P Pitsiladis, Toshifumi Ozaki, Darryl D'Lima, Martin Lotz, Ardem Patapoutian, Hiroshi Asahara. The mechanosensitive ion channel PIEZO1 is expressed in tendons and regulates physical performance. Sci Transl Med. 2022.06; 14 (647): eabj5557. ( PubMed, DOI )

  6. Yuta Fujii, Lin Liu, Lisa Yagasaki, Maiko Inotsume, Tomoki Chiba, Hiroshi Asahara. Cartilage Homeostasis and Osteoarthritis. Int J Mol Sci. 2022.06; 23 (11): ( PubMed, DOI )

  7. Kaho Takada, Tomoki Chiba, Takayuki Miyazaki, Lisa Yagasaki, Ryo Nakamichi, Takanori Iwata, Keiji Moriyama, Hiroyuki Harada, Hiroshi Asahara. Single Cell RNA Sequencing Reveals Critical Functions of Mkx in Periodontal Ligament Homeostasis Front Cell Dev Biol. 2022.02; 10 795441. ( PubMed, DOI )

  8. Hiroki Tsutsumi, Ryota Kurimoto, Ryo Nakamichi, Tomoki Chiba, Takahide Matsushima, Yuta Fujii, Risa Sanada, Tomomi Kato, Kana Shishido, Yuriko Sakamaki, Tsuyoshi Kimura, Akio Kishida, Hiroshi Asahara. Generation of a tendon-like tissue from human iPS cells. J Tissue Eng. 2022.01; 13 20417314221074018. ( PubMed, DOI )

  9. Yoshiaki Ito, Tokio Matsuzaki, Fumiaki Ayabe, Sho Mokuda, Ryota Kurimoto, Takahide Matsushima, Yusuke Tabata, Maiko Inotsume, Hiroki Tsutsumi, Lin Liu, Masahiro Shinohara, Yoko Tanaka, Ryo Nakamichi, Keiichiro Nishida, Martin K Lotz, Hiroshi Asahara. Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis. Nat Commun. 2021.07; 12 (1): 4148. ( PubMed, DOI )

  10. Takayuki Miyazaki, Ryota Kurimoto, Tomoki Chiba, Takahide Matsushima, Ryo Nakamichi, Hiroki Tsutsumi, Kaho Takada, Lisa Yagasaki, Tomomi Kato, Kana Shishido, Yukiho Kobayashi, Tsutomu Matsumoto, Keiji Moriyama, Hiroshi Asahara. Mkx regulates the orthodontic tooth movement via osteoclast induction. J Bone Miner Metab. 2021.05; ( PubMed, DOI )

  11. Yutaro Uchida, Takahide Matsushima, Ryota Kurimoto, Tomoki Chiba, Yuki Inutani, Hiroshi Asahara. Identification of chemical compounds regulating PD-L1 by introducing HiBiT-tagged cells. FEBS Lett. 2021.03; 595 (5): 563-576. ( PubMed, DOI )

  12. Momo Isobe, Hikaru Toya, Mari Mito, Tomoki Chiba, Hiroshi Asahara, Tetsuro Hirose, Shinichi Nakagawa. Forced isoform switching of Neat1_1 to Neat1_2 leads to the loss of Neat1_1 and the hyperformation of paraspeckles but does not affect the development and growth of mice. RNA. 2019.12; ( PubMed, DOI )

  13. Nakasuji T, Ogonuki N, Chiba T, Kato T, Shiozawa K, Yamatoya K, Tanaka H, Kondo T, Miyado K, Miyasaka N, Kubota T, Ogura A, Asahara H. Complementary critical functions of Zfy1 and Zfy2 in mouse spermatogenesis and reproductiontran PLoS Genetics. 2017.01; 13 (1): e1006578.

  14. T. Chiba, Y. Ito, H. Asahara.. Post-Transcriptional Gene Regulation by MicroRNA and RNA-Binding Protein Biomedical Sciences. 2016;

  15. Yohei Matsubara, Tomoko Kato, Kenichi Kashimada, Hiromitsu Tanaka, Zhou Zhi, Shizuko Ichinose, Shuki Mizutani, Tomohiro Morio, Tomoki Chiba, Yoshiaki Ito, Yumiko Saga, Shuji Takada, and Hiroshi Asahara. TALEN-Mediated Gene Disruption on Y Chromosome Reveals Critical Role of EIF2S3Y in Mouse Spermatogenesis Stem cells and development. 2015;

  16. Yohei Matsubara, Tomoki Chiba, Kenichi Kashimada, Tomohiro Morio, Shuji Takada, Shuki Mizutani, Hiroshi Asahara. Transcription activator-like effector nuclease-mediated transduction of exogenous gene into IL2RG locus. Sci Rep. 2014; 4 5043. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. 劉琳、宮田康平、中道亮、千葉朋希、淺原弘嗣. Rp58による筋サテライト細胞の制御. 第9回日本筋学会学術集会 2023.08.18

  2. 矢ヶ﨑理紗、千葉朋希、栗本遼太、浅原弘嗣. Mkxノックアウトラットを用いたMkxの歯周病における役割の解明. 第9回日本筋学会学術集会 2023.08.18

  3. 矢ヶ﨑理紗、千葉朋希、栗本遼太、淺原弘嗣. Mkxノックアウトラットを用いたMkxの歯周病における役割の解明. 第41回日本骨代謝学会学術集会 2023.07.29

  4. 劉琳、千葉朋希、浅原弘嗣. 新規コンディショナルMkxノックアウトマウスの作製と特性評価. 第41回日本骨代謝学会学術集会 2023.07.28

  5. Ryota Kurimoto、Waka Miyamoto、Maiko Inotsume、Reiji Hirai、Tomoki Chiba、Takahide Matsushima、Yutaro Uchida、Yuta Fujii、Yuki Naito、Yuichi Shichino、Mari Mito、Shintaro Iwasaki、Hiroshi Asahara. Regulation of lung cancer metastasis by the RNA-modifying enzyme. 第24回日本RNA学会年会 2023.07.05

  6. Yutaro Uchida、Ryota Kurimoto、Tomoki Chiba、Yasuto Takeuchi、Noriko Gotoh、Hiroshi Asahara. Post-transcriptional regulation of breast cancer stemness by the novel RNA binding protein. RNA2023 2023.05.31

  7. 劉琳、千葉朋希、淺原弘嗣、. Generation and analysis of conditional Mkx knockout mice. 第40回日本骨代謝学会学術集会 2022.07.22

  8. Yutaro Uchida, Ryota Kurimoto, Tomoki Chiba, Yasuto Takeuchi, Noriko Gotoh, Hiroshi Asahara. Post-transcriptional regulation of breast cancer stemness by the novel RNA binding protein. 第23回日本RNA学会年会 2022.07.21

  9. Ryota Kurimoto, Waka Miyamoto, Maiko Inotsume, Tomoki Chiba, TakahideMatsushima, YutaroUchida, Yuta Fujii, Hiroshi Asahara.. Regulation of lung cancer metastasis by the RNA-modifying enzyme. 2022.07.21

  10. Lisa Yagasaki, Tomoki Chiba, Ryota Kurimoto, Takanori Iwata, Hiroshi Asahara. Understanding the role of Mkx in periodontal disease through utilisation of Mkx knockout rats. 第7回日本骨免疫学会 2022.06.30

  11. Lin Liu, Tomoki Chiba, Hiroshi Asahara. Generation and characterization of a novel conditional Mkx knockout mice. 第7回日本骨免疫学会 2022.06.29

  12. Lin Liu, Tomoki Chiba, Ryota Kurimoto, Hiroki Tsutsumi, Yuta Fujii, Hiroshi Asahara. Single-cell transcriptome profiles in mouse limb buds . 第7回日本筋学会学術集会 2021.12.11

  13. Yutaro Uchida, Takahide Matsushima, Ryota Kurimoto, Tomoki Chiba, Yuki lnutani, Hiroshi Asahara.. HiBiT tagging system for high throughput chemical screening for chemotherapy. AACR 2021 2021.04.11

  14. Hiroshi Asahara, Sho Mokuda, Yoshiaki Ito, Masafumi Inui, Ryo Nakamichi, Tomoki Chiba, Ryota Kurimoto, Takahide Matsushima. miRNAs in arthritis pathogenesis and therapy. The 24th Annual Meeting of the RNA Society 2019.06.14

  15. Tomoki Chiba,Hiroshi Asahara. Regulation of inflammatory cytokine expression by long non-coding RNA LASC. RNA2017 2017.07.19

  16. Tomoki Chiba,Hiroshi Asahara. Regulation of inflammatory cytokine expression by long non-coding RNA LASC. The 43rd Naito Conference 2017.06.27

  17. Kensuke Kataoka, Yoshiaki, Ito, Tomoki Chiba, Ryo Nakamichi and Hiroshi Asahara. Tendon regeneration and development by transcription factor Mkx. The 1st international symposium on creation of life innovation materials for interdisciplinary and international researcher development 2016.10.17

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Patents 【 display / non-display 】

  • INHIBITOR OF THE EXPRESSION OF CANCER-PROMOTING FACTORS, SCREENING METHOD FOR ACTIVE INGREDIENT THEREOF, EXPRESSION CASSETTE USEFUL IN SAID METHOD, DIAGNOSTIC DRUG, AND DIAGNOSTIC METHOD

    Patent Number： IL 274456

  • ARTIFICIAL TENDON OR LIGAMENT TISSUE PRODUCED USING THREE-DIMENSIONAL MECHANOSIGNALING CELL CULTURE SYSTEM

    Patent Number： US 11773376

  • EXPRESSION INHIBITOR OF INFLAMMATION PROMOTING FACTORS, SCREENING METHOD FOR ACTIVE INGREDIENT THEREOF, EXPRESSION CASSETTE USEFUL FOR SAID METHOD, DIAGNOSTIC AGENT AND DIAGNOSIS METHOD

    Patent Number： I780046

  • EXPRESSION INHIBITOR OF INFLAMMATION PROMOTING FACTORS, SCREENING METHOD FOR ACTIVE INGREDIENT THEREOF, EXPRESSION CASSETTE USEFUL FOR SAID METHOD, DIAGNOSTIC AGENT AND DIAGNOSIS METHOD

    Patent Number： ZL201780042802.0

  • EXPRESSION INHIBITOR OF INFLAMMATION PROMOTING FACTORS, SCREENING METHOD FOR ACTIVE INGREDIENT THEREOF, EXPRESSION CASSETTE USEFUL FOR SAID METHOD, DIAGNOSTIC AGENT AND DIAGNOSIS METHOD

    Patent Number： AU 2017264192

  • EXPRESSION INHIBITOR OF INFLAMMATION PROMOTING FACTORS, SCREENING METHOD FOR ACTIVE INGREDIENT THEREOF, EXPRESSION CASSETTE USEFUL FOR SAID METHOD, DIAGNOSTIC AGENT AND DIAGNOSIS METHOD

    Patent Number： IL 262794

  • EXPRESSION INHIBITOR OF INFLAMMATION PROMOTING FACTORS, SCREENING METHOD FOR ACTIVE INGREDIENT THEREOF, EXPRESSION CASSETTE USEFUL FOR SAID METHOD, DIAGNOSTIC AGENT AND DIAGNOSIS METHOD

    Patent Number： KR 10-2584661

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Others 【 display / non-display 】

  • Revealing the function of Mkx in periodontal ligament homeostasis，2022.02

    AAAS EurekAlert! The Global Source for Science News

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