Personnel Information

写真a

ASANO Toshifumi


Job title

Assistant Professor

Homepage URL

http://www.tmd.ac.jp/english/cbio/index.html

Research Areas, Keywords

Cell Engineering, Optogenetics, Muscle Development
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Graduate School 【 display / non-display 】

  • The Graduate University for Advanced Studies, Doctor's Course, 2009.03, Completed

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Degree 【 display / non-display 】

  • Doctor of Philosophy

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Campus Career 【 display / non-display 】

  • 2015.01
    -
    2018.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Matrix， Cell Biology， Assistant Professor
  • 2018.04
    -
    2020.05
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Matrix， Cell Biology， Assistant Professor
  • 2020.06
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Matrix， Cell Biology， Assistant Professor
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External Career 【 display / non-display 】

  • 2007.04
    -
    2009.03
    Japan Society for the Promotion of Science, School of Physical Sciences, The Graduate University for Advanced Studies, Research Fellow (DC2)
  • 2009.04
    -
    2010.03
    Institute for Molecular Science, Division of Biomolecular Sensing, Postdoctoral Fellow
  • 2010.04
    -
    2013.03
    Japan Society for the Promotion of Science, Graduate School of Life Sciences, Tohoku University, Research Fellow (PD)
  • 2013.03
    -
    2014.12
    Osaka University, Graduate School of Engineering, Assistant Professor
  • 2018.10
    -
    2020.01
    University of Bonn, Institute for Physiology I, Visiting Researcher (Concurrent post)
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Academic Society Affiliations 【 display / non-display 】

  • The Molecular Biology Society of Japan

  • The Japanese Society for Regenerative Medicine

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Research Areas 【 display / non-display 】

  • Cell biology

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Published Papers & Misc 【 display / non-display 】

  1. Toshifumi Asano, Philipp Sasse, Takao Nakata. Development of a Cre-recombination-based color-switching reporter system for cell fusion detection. Biochem Biophys Res Commun. 2024.01; 690 149231. ( PubMed, DOI )

  2. Aiko Takada, Toshifumi Asano, Ken-Ichi Nakahama, Takashi Ono, Takao Nakata, Tomohiro Ishii. Development of an optogenetics tool, Opto-RANK, for control of osteoclast differentiation using blue light. Sci Rep. 2024.01; 14 (1): 1749. ( PubMed, DOI )

  3. Tomoya Uchimura, Toshifumi Asano, Takao Nakata, Akitsu Hotta, Hidetoshi Sakurai. A muscle fatigue-like contractile decline was recapitulated using skeletal myotubes from Duchenne muscular dystrophy patient-derived iPSCs. Cell Reports Medicine. 2021.06; 2 (6): 100298. ( PubMed, DOI )

  4. Toshifumi Asano, Daniel Boon Loong Teh, Hiromu Yawo. Application of Optogenetics for Muscle Cells and Stem Cells Advances in Experimental Medicine and Biology. 2021.01; 1293 359-375. ( PubMed, DOI )

  5. Moe Sato, Toshifumi Asano, Jun Hosomichi, Takashi Ono, Takao Nakata. Optogenetic manipulation of intracellular calcium by BACCS promotes differentiation of MC3T3-E1 cells. Biochemical and Biophysical Research Communications. 2018.11; 506 (3): 716-722. ( PubMed, DOI )

  6. Toshifumi Asano, Hiroyuki Igarashi, Toru Ishizuka, Hiromu Yawo. Organelle Optogenetics: Direct Manipulation of Intracellular Ca2+ Dynamics by Light Frontiers in Neuroscience. 2018.08; 12 561. ( PubMed, DOI )

  7. Toshifumi Asano, Toru Ishizuka, Hiromu Yawo. Myogenic Maturation by Optical-Training in Cultured Skeletal Muscle Cells. Methods in Molecular Biology. 2017.08; 1668 135-145. ( PubMed, DOI )

  8. Toshifumi Asano, Toru Ishizuka, Hiromu Yawo, Keisuke Morishima. Development of biotrandcusers driven by photostimulation Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS2015). 2015.06; 1605-1608.

  9. Toshifumi Asano, Toru Ishizuka, Keisuke Morishima, Hiromu Yawo. Optogenetic induction of contractile ability in immature C2C12 myotubes Scientific Reports. 2015.02; 5 8317. ( PubMed, DOI )

  10. Masaya Hirooka, Sze Ping Beh, Toshifumi Asano, Yoshitake Akiyama, Takayuki Hoshino, Keita Hoshino, Hidenobu Tsujimura, Kikuo Iwabuchi, Keisuke Morishima. Evaluation and optical control of somatic muscle micro bioactuator of channelrhodopsin transgenic drosophila melano-gaster 2014 IEEE 27th International Conference on Micro Electro Mechanical Systems (MEMS). 2014.01; 196-199. ( DOI )

  11. Hiromu Yawo, Toshifumi Asano, Seiichiro Sakai, Toru Ishizuka. Optogenetic manipulation of neural and non-neural functions. Development Growth and Differentiation. 2013.05; 55 (4): 474-490. ( PubMed, DOI )

  12. Ayumi Ando, Toshifumi Asano, Md. Abu Sayed, Ryugo Tero, Katsuhisa Kitano, Tsuneo Urisu, Satoshi Hamaguchi. Extracellular Matrix Patterning for Cell Alignment by Atmospheric Pressure Plasma Jets Japanese Journal of Applied Physics. 2012.03; 51 (3 1): 036201. ( DOI )

  13. Toshifumi Asano, Toru Ishizuka, Hiromu Yawo. Optically controlled contraction of photosensitive skeletal muscle cells. Biotechnology and Bioengineering. 2012.01; 109 (1): 199-204. ( PubMed, DOI )

  14. Ayumi Ando, Toshifumi Asano, Tsuneo Urisu, Satoshi Hamaguchi. Micro-pattern formation of extracellular matrix (ECM) layers by atmospheric-pressure plasmas and cell culture on the patterned ECMs Journal of physics D: Applied physics. 2011.12; 44 (48): 482002. ( DOI )

  15. Toshifumi Asano, Takuya Nakamura, Akihiro Wakahara, Tsuneo Urisu. Noise Properties of Incubation-Type Planar Ion Channel Biosensor Japanese Journal of Applied Physics. 2009.02; 48 (2): 027001. ( DOI )

  16. Yuichi Utsumi, Toshifumi Asano, Yoshiaki Ukita, Katsuhiro Matsui, Masahiro Takeo, Seiji Negoro. High sensitive immunoassay for endocrine disrupting chemicals using antibody immobilized microcapillary bundle structure Microsystem Technologies. 2008.10; 14 (9-11): 1399-1403. ( DOI )

  17. Tsuneo Urisu, Toshifumi Asano, Zhenlong Zhang, Hidetaka Uno, Ryugo Tero, Han Junkyu, Isoda Hiroko, Yusuke Arima, Hiroo Iwata, Koji Shibasaki, Makoto Tominaga. Incubation type Si-based planar ion channel biosensor Analytical and Bioanalytical Chemistry. 2008.08; 391 (8): 2703-2709. ( PubMed, DOI )

  18. Toshifumi Asano, Hidetaka Uno, Koji Shibasaki, Makoto Tominag and Tsuneo Urisu. A Cell-Culture-Type Planar Ion Channel Biosensor Transactions of the Materials Research Society of Japan. 2008; 33 767-770.

  19. Yoshiaki Ukita, Toshifumi Asano, Kuniyo Fujiwara, Katsuhiro Matsui, Masahiro Takeo and Seiji Negoro, Tomohiko Kanie, Makoto Katayama, Yuichi Utsumi. Application of vertical microreactor stack with polystylene microbeads to immunoassay Sensors and Actuators A: Physical. 2008; 145 (SI): 449-455. ( DOI )

  20. Katsuhiro Matsui, Isao Kawaji, Yuichi Utsumi, Yoshiaki Ukita, Toshifumi Asano, Masahiro Takeo, Dai-ichiro Kato, Seiji Negoro. Immunoassay using microfluid filters constructed by deep X-ray lithography. Bioscience, Biotechnology, and Biochemistry. 2007.12; 71 (12): 3098-3101. ( PubMed, DOI )

  21. Katsuhiro Matsui, Isao Kawaji, Yuichi Utsumi, Yoshiaki Ukita, Toshifumi Asano, Masahiro Takeo, Dai-ichiro Kato, Seiji Negoro. Enzyme-linked immunosorbent assay for nonylphenol using antibody-bound microfluid filters in vertical fluidic operation. Journal of Bioscience and Bioengineering. 2007.10; 104 (4): 347-350. ( PubMed, DOI )

  22. Yoshiaki Ukita, Toshifumi Asano, Yuichi Utsumi. Fluid filter fabricated by deep X-ray lithography for micro fluidics Microsystem Technologies. 2007.03; 13 (5-6): 435-439. ( DOI )

  23. Toshifumi Asano, Yoshiaki Ukita, Katsuhiro Matsui, Masahiro Takeo, Seiji Negoro, Yuichi Utsumi. Fabrication of a micro reactor for vertical unit operation using multifunctional fluid filter and its application to biochemical reaction Microsystem Technologies. 2007.03; 13 (5-6): 441-446. ( DOI )

  24. Yoshiaki Ukita, Toshifumi Asano, Kuniyo Fujiwara, Takuya Yokoyama, Katsuhiro Matsui, Masahiro Takeo, Seiji Negoro, Tsunemasa Saiki, Yuichi Utsumi. Novel characteristics of multifunctional fluid filters fabricated by high-energy synchrotron radiation lithography Japanese Journal of Applied Physics. 2006.09; 45 (9A): 7203-7208. ( DOI )

  25. Yuichi Utsumi, Toshifumi Asano, Yoshiaki Ukita, Katsuhiro Matsui, Masahiro Takeo, Seiji Negoro. Proposal of a new microreactor for vertical chemical operation Journal of vacuum science and technologies B. 2006; 24 2606-2610.

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Books etc 【 display / non-display 】

  1. Toshifumi Asano, Toru Ishizuka, Hiromu Yawo. Muscular Optogenetics: Controlling Muscle Functions with Light. Muscle Cells: Development, Disorders and Regeneration, Nova Science Publishers， 2013.01 127-136 (Chapter 5) (ISBN : 978-1-62417-233-5)

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Conference Activities & Talks 【 display / non-display 】

  1. Toshifumi Asano, Toru Ishizuka, Hiromu Yawo, Keisuke Morishima. Development of biotrandcusers driven by photostimulation. 18th International Conference on Solid-State Sensors, Actuators and Microsystems Transducers 2015 2015.06.21 Alaska, USA

  2. Toshifumi Asano, Toru Ishizuka, Hiromu Yawo, Keisuke Morishima. Optically controllable muscle for cell-based microdevice. 2014 International Symposium on Micro-NanoMechatronics and Human Science (MHS2014) 2014.11.09 Nagoya, Japan

  3. Toshifumi Asano, Toru Ishizuka, Hiromu Yawo, Keisuke Morishima. Optogenetic manipulation of myogenic contraction and maturation in skeletal muscle cells. Optogenetics2013 2013.09.26 慶応義塾大学

  4. 浅野豪文，石塚 徹，八尾 寛. Optogenetic manipulation of myogenic contraction and maturation in channelrhodopsin-expressing skeletal muscle myotubes. 第50回日本生物物理学会年会 2012.09.22 名古屋大学

  5. Toshifumi Asano, Yugo Fukazawa, Ryuichi Shigemoto, Toru Ishizuka, Hiromu Yawo, Tsuneo Urisu. Planar Ion channel biosensor for Neural Network Function Analysis. 19th Symposium of the Materials Research Society of Japan (MRS-J) 2009.12.07 Yokohama, Japan

  6. Toshifumi Asano, Yugo Fukazawa, Ryuichi Shigemoto, Toru Ishizuka, Hiromu Yawo, Tsuneo Urisu. Cell Patterning by Optimized Extracellular MatrixPattern on the Micropore-electrode of Planar Ion Channel Biosensor. 3rd International Symposium on Nanomedicine (ISNM2009-2) and Molecular Imaging and Systems Biology 2009.11.04 Aichi, Japan

  7. Toshifumi Asano, Koji Shibasaki, Makoto Tominaga, Tsuneo Urisu. Development of Cell Culture Type Planar Ion Channel Biosensor for Nerve Cell Signaling Analysis. Gordon Research Conference on Biointerface Science 2008.09.14 Aussois, France

  8. Toshifumi Asano, Koji Shibasaki, Makoto Tominaga, Tsuneo Urisu. Development of Cell Culture Type Planar Ion Channel Biosensor for Nerve Cell Signaling Analysis. 3rd International Workshop on Approaches to Single-cell Analysis 2008.09.11 Zurich, Switzerland

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Awards & Honors 【 display / non-display 】

  • Best Poster Award，2014 International Symposium on Micro-NanoMechatronics and Human Science (MHS2014)，2014.11

  • Award for Encouragement of Research of Materials Science，19th Symposium of Materials Research Society of Japan，2010.01

  • The Best Poster Award，2nd International Symposium on Nanomedicine，2009.02

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Campus class subject 【 display / non-display 】

  • Histology，2020 - Now

  • Histology，2016 - 2018

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