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YOSHIOKA Kotaro
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Graduating School 【 display / non-display 】
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Tokyo Medical and Dental University, Faculty of Medicine, 2007.03, Graduated
Graduate School 【 display / non-display 】
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Tokyo Medical and Dental University, Graduate School, Division of Medicine, Doctor's Course, Completed
Campus Career 【 display / non-display 】
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2009.04-2010.05Tokyo Medical and Dental University, (Old Organization)Medical Hospital, Hospital Departments, Department of Neurology, Neurosurgery,Psychiatry and Anesthesiology, Neurology, Senior Resident
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2012.04-2016.03Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Cognitive and Behavioral Medicine, Neurology and Neurological Science, Graduate Student
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2016.04-2020.06Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Cognitive and Behavioral Medicine, Neurology and Neurological Science, Project Assistant Professor
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2020.07-2022.03Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Cognitive and Behavioral Medicine, Neurology and Neurological Science, Assistant Professor
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2022.04-2024.03Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Cognitive and Behavioral Medicine, Neurology and Neurological Science, Project Assistant Professor
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2024.04-NowTokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Cognitive and Behavioral Medicine, Neurology and Neurological Science, Project Junior Associate Professor
External Career 【 display / non-display 】
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2007.04-2009.03, Trainee Resident
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2010.06-2012.03, Senior Resident
Published Papers & Misc 【 display / non-display 】
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Yanagidaira M, Yoshioka K, Nagata T, Nakao S, Miyata K, Yokota T. Effects of combinations of gapmer antisense oligonucleotides on the target reduction. Molecular biology reports. 2023.04; 50 (4): 3539-3546. ( PubMed, DOI )
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Li F, Ichinose K, Ishibashi S, Yamamoto S, Iwasawa E, Suzuki M, Yoshida-Tanaka K, Yoshioka K, Nagata T, Hirabayashi H, Mogushi K, Yokota T. Preferential delivery of lipid-ligand conjugated DNA/RNA heteroduplex oligonucleotide to ischemic brain in hyperacute stage. Molecular therapy : the journal of the American Society of Gene Therapy. 2023.04; 31 (4): 1106-1122. ( PubMed, DOI )
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Jia C, Lei Mon SS, Yang Y, Katsuyama M, Yoshida-Tanaka K, Nagata T, Yoshioka K, Yokota T. Change of intracellular calcium level causes acute neurotoxicity by antisense oligonucleotides via CSF route. Molecular therapy. Nucleic acids. 2023.03; 31 182-196. ( PubMed, DOI )
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Koide T, Mandai S, Kitaoka R, Matsuki H, Chiga M, Yamamoto K, Yoshioka K, Yagi Y, Suzuki S, Fujiki T, Ando F, Mori T, Susa K, Iimori S, Naito S, Sohara E, Rai T, Yokota T, Uchida S. Circulating Extracellular Vesicle-Propagated microRNA Signature as a Vascular Calcification Factor in Chronic Kidney Disease. Circulation research. 2023.02; 132 (4): 415-431. ( PubMed, DOI )
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Nagata T, Dwyer CA, Yoshida-Tanaka K, Ihara K, Ohyagi M, Kaburagi H, Miyata H, Ebihara S, Yoshioka K, Ishii T, Miyata K, Miyata K, Powers B, Igari T, Yamamoto S, Arimura N, Hirabayashi H, Uchihara T, Hara RI, Wada T, Bennett CF, Seth PP, Rigo F, Yokota T. Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS. Nature biotechnology. 2021.12; 39 (12): 1529-1536. ( PubMed, DOI )
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Motohiro Suzuki, Satoru Ishibashi, Eri Iwasawa , Takahiro Oguma, Yasuhiro Saito, Fuying Li, Shinichi Otsu, Keiko Ichinose, Kotaro Yoshioka, Tetsuya Nagata, Takanori Yokota. Effective silencing of miR-126 after ischemic stroke by means of intravenous α-tocopherol-conjugated heteroduplex oligonucleotide in mice. Scientific reports. 2021.07; 11 (1): 14237. ( PubMed, DOI )
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Daisuke Ono, Ken Asada, Daishi Yui, Fumika Sakaue, Kotaro Yoshioka, Tetsuya Nagata, Takanori Yokota. Separation-related rapid nuclear transport of DNA/RNA heteroduplex oligonucleotide: unveiling distinctive intracellular trafficking. Molecular therapy. Nucleic acids. 2021.03; 23 1360-1370. ( PubMed, DOI )
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Yuki Kishimoto, Osamu Nakagawa, Akane Fujii, Kotaro Yoshioka, Tetsuya Nagata, Takanori Yokota, Yoshiyuki Hari, Satoshi Obika. 2',4'-BNA/LNA with 9-(2-Aminoethoxy)-1,3-diaza-2-oxophenoxazine Efficiently Forms Duplexes and Has Enhanced Enzymatic Resistance*. Chemistry (Weinheim an der Bergstrasse, Germany). 2021.02; 27 (7): 2427-2438. ( PubMed, DOI )
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Asami Yutaro, Nagata Tetsuya, Yoshioka Kotaro, Kunieda Taiki, Yoshida-Tanaka Kie, Bennett C. Frank, Seth Punit P., Yokota Takanori. Efficient Gene Suppression by DNA/DNA Double-Stranded Oligonucleotide In Vivo. Molecular therapy : the journal of the American Society of Gene Therapy. 2021.02; 29 (2): 838-847. ( PubMed, DOI )
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Lei Mon SS, Yoshioka K, Jia C, Kunieda T, Asami Y, Yoshida-Tanaka K, Piao W, Kuwahara H, Nishina K, Nagata T, Yokota T. Highly efficient gene silencing in mouse brain by overhanging-duplex oligonucleotides via intraventricular route. FEBS letters. 2020.05; 594 (9): 1413-1423. ( PubMed, DOI )
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Yoshioka K, Kunieda T, Asami Y, Guo H, Miyata H, Yoshida-Tanaka K, Sujino Y, Piao W, Kuwahara H, Nishina K, Hara RI, Nagata T, Wada T, Obika S, Yokota T. Highly efficient silencing of microRNA by heteroduplex oligonucleotides. Nucleic acids research. 2019.08; 47 (14): 7321-7332. ( PubMed, DOI )
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Ozaki Kokoro, Ohkubo Takuya, Yamada Tetsuo, Yoshioka Kotaro, Ichijo Masahiko, Majima Takamasa, Kudo Shunsuke, Akashi Takumi, Honda Keiji, Ito Eisaku, Watanabe Mayumi, Sekine Masaki, Hamagaki Miwako, Eishi Yoshinobu, Sanjo Nobuo, Ishibashi Satoru, Mizusawa Hidehiro, Yokota Takanori. Progressive Encephalomyelitis with Rigidity and Myoclonus Resolving after Thymectomy with Subsequent Anasarca: An Autopsy Case Internal Medicine. 2018.12; 57 (23): 3451-3458. ( ichushi )
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Guo Huijia, Yoshioka Kotaro, Kunieda Taiki, Asami Yutaro, Miyata Haruka, Yoshida-Tanaka Kie, Nagata Tetsuya, Yokota Takanori. Efficacy of microRNA silencing by lipid-conjugated double-stranded antisense oligonucleotides Journal of Medical and Dental Sciences. 2018.06; 65 (2): 83-88. ( ichushi )
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Yutaro Asami, Kotaro Yoshioka, Kazutaka Nishina, Tetsuya Nagata, Takanori Yokota. Drug delivery system of therapeutic oligonucleotides. Drug Discov Ther. 2016.10; 10 (5): 256-262. ( PubMed, DOI )
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Kotaro Yoshioka, Kosuke Watanabe, Satoshi Zeniya, Yoko Ito, Masaki Hizume, Toshiro Kanazawa, Makoto Tomita, Satoru Ishibashi, Hirotomo Miake, Hiroaki Tanaka, Takanori Yokota, Hidehiro Mizusawa. A Score for Predicting Paroxysmal Atrial Fibrillation in Acute Stroke Patients: iPAB Score. J Stroke Cerebrovasc Dis. 2015.10; 24 (10): 2263-2269. ( PubMed, DOI )
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Kazutaka Nishina, Wenying Piao, Kie Yoshida-Tanaka, Yumiko Sujino, Tomoko Nishina, Tsuyoshi Yamamoto, Keiko Nitta, Kotaro Yoshioka, Hiroya Kuwahara, Hidenori Yasuhara, Takeshi Baba, Fumiko Ono, Kanjiro Miyata, Koichi Miyake, Punit P Seth, Audrey Low, Masayuki Yoshida, C Frank Bennett, Kazunori Kataoka, Hidehiro Mizusawa, Satoshi Obika, Takanori Yokota. DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing. Nat Commun. 2015.08; 6 7969. ( PubMed, DOI )
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Kotaro Yoshioka, Satoru Ishibashi, Atsushi Shiraishi, Takanori Yokota, Hidehiro Mizusawa. Distal hyperintense vessels on FLAIR images predict large-artery stenosis in patients with transient ischemic attack. Neuroradiology. 2013.02; 55 (2): 165-169. ( PubMed, DOI )
Books etc 【 display / non-display 】
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Yoshioka K, Nishina K, Nagata T, Yokota T.. Molecular Technology: Life Innovation. Wiley-VCH, Weinheim, 2018.12 DNA/RNA Heteroduples Oligonucleotides.
Conference Activities & Talks 【 display / non-display 】
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Jia Chunyan, Yoshioka Kotaro, Su Su Lei Mon , Katsuyama Maho, Tanaka-Yoshida Kie, Nagata Tetsuya, Yokota Takanori. Hetereoduplex oligonucleotiedeによるCSFを介した各種急性中枢神経毒性の軽減効果(Hetereoduplex oligonucleotiede mitigates various types of acute CNS toxicities via CSF route). 臨床神経学 2021.09.01
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Su Su Lei Mon , Yoshioka Kotaro, Jia Chunyan, Kunieda Taiki, Asami Yutaro, Yoshida-Tanaka Kie, Piao Wenying, Kuwahara Hiroya, Nishina Kazutaka, Nagata Tetsuya, Yokota Takanori. オーバーハング2本鎖核酸の脳室内投与による効果増強と毒性の緩和(Overhanging duplex oligonucleotide enhances potency and mitigates toxicity intracerebroventricularly). 臨床神経学 2021.09.01
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Jia Chunyan, Yoshioka Kotaro, Mon Su Su Lei, Tanaka Kie, Nagata Tetsuya, Yokota Takanori. CNS疾患に対するヘテロ二重鎖オリゴヌクレオチド使用による治療指標の改善(Hetereoduplex oligonucleotides technology improves therapeutic index for CNS diseases). 臨床神経学 2020.11.01
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Yoshioka Kotaro, Kunieda Taiki, Asami Yutaro, Tanaka Kie, Piao Wenying, Kuwahara Hiroya, Nishina Kazutaka, Nagata Tetsuya, Yokota Takanori. オーバーハングしたヘテロ二重鎖オリゴヌクレオチドを用いたFAPのトランスフェリンを介した送達による治療(Treatment for FAP with overhanging heteroduplex oligonucleotides by transferrin-mediated delivery). 臨床神経学 2020.11.01
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Yoshioka Kotaro, Su Su Lei Mon , Jia Chunyan, Yamada Hiroki, Asami Yutaro, Tanaka Kie, Wenying Piao, Kuwahara Hiroya, Nishina Kazutaka, Nagata Tetsuya, Yokota Takanori. CNSを標的としたオーバーハングヘテロ二2本鎖核酸を用いた新しいアンチセンスオリゴヌクレオチド治療(A novel antisense oligonucleotide therapy by overhanging heteroduplex oligonucleotide targeting CNS). 臨床神経学 2019.11.01
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1. Yoshioka K, Kunieda T, Asami Y, Huijia G, Miyata H, Tanaka K, Sujino Y, Piao W, Kuwahara H, Nishina K, Iwata-Hara R, Nagata T, Wada T, Obika S, Yokota T. . Heteroduplex-oligonucleotides for highly efficient silencing of microRNA through a novel intracellular mechanism. 15th Annual Meeting of the Oligonucleotide Therapeutics Society 2019.10.16
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Mon Su Su Lei, Yoshioka Kotaro, Kunieda Taiki, Asami Yutaro, Tanaka Kie, Piao Wenying, Kuwahara Hiroya, Nishina Kazutaka, Nagata Tetsuya, Yokota Takanori. アンチセンスオリゴヌクレオチド二本鎖の新しい構造は脳室内経路を介した効果を改善する(A novel structure of duplex antisense oligonucleotides improves potency via intraventricular route). 臨床神経学 2018.12.01
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Yoshioka Kotaro, Kunieda Taiki, Asami Yutaro, Guo Huija, Enomoto Seiya, Miyata Haruka, Tanaka Kie, Piao Wenying, Kuwahara Hiroya, Nishina Kazutaka, Nagata Tetsuya, Yokota Takanori. 新しい種類の二本鎖オリゴヌクレオチドはin vivoにおいてmicroRNAサイレンシングの効力を増強する(A new class of double-stranded oligonucleotide enhances in vivo potency of microRNA silencing). 臨床神経学 2018.12.01
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Kotaro Yoshioka, Taiki Kunieda, Yutaro Asami, Yumiko Sujino, Kie Tanaka, Wenying Piao, Hiroya Kuwahara, Kazutaka Nishina, Tetsuya Nagata and Takanori Yokota. Dual overhanging-duplex oligonucleotide improved efficacy and safety in gene therapy for FAP. XX Ⅲ World Congress of Neurology 2017.09.20 Kyoto, JPN
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Nishina Kazutaka, Yoshioka Kotaro, Nishina Tomoko, Kuwahara Hiroya, Nagata Tetsuya, Yokota Takanori. DNA/RNAヘテロ二本鎖構造に基づく新規オリゴヌクレオチド(Novel oligonucleotide based on DNA/RNA heteroduplex structures). 臨床神経学 2016.12.01
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Li Fuying, Ishibashi Satoru, Yoshioka Kotaro, Wada Takehiko, Ichijo Masahiko, Iwasawa Eri, Song Jindong, Zhang Yongquan, Yokota Takanori. ヘテロ二重鎖オリゴヌクレオチドはマウス局所脳虚血において遺伝子発現を低下させる(Heteroduplex oligonucleotide reduced gene expression in focal ischemic brain in mice). 臨床神経学 2016.12.01
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Yoshioka Kotaro, Kunieda Taiki, Tanaka Kie, Piao Wenying, Kuwahara Hiroya, Nishina Kazutaka, Nagata Tetsuya, Yokota Takanori. 新型の二本鎖構造はFAPに対するアンチセンスオリゴヌクレオチドの効能を改善させる(A new type of double-stranded structure improved potency of antisense oligonucleotide for FAP). 臨床神経学 2016.12.01
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吉岡 耕太郎, 筋野 裕美子, 國枝 泰希, 下 剛典, 田中 規恵, 朴 文英, 桑原 宏哉, 仁科 一隆, 小比賀 聡, 横田 隆徳. Hetero-chimera-duplex-oligonucleotideによるエクソンスキッピング療法の開発(Development of exon-skipping therapy by hetero-chimera-duplex oligonucleotide). 臨床神経学 2015.12.01
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Kotaro Yoshioka, Yumiko Sujino, Kie Tanaka, Wenying Piao, Tomoko Nishina, Hiroya Kuwahara, Kazutaka Nishina, Takanori Yokota.. Hetero-chimera-duplex oligonucleotide (HCDO): A new class of oligonucleotide for enhancement of efficacy of microRNA inhibitor.. 10th annual meeting of the Oligonucleotide Therapeutics Society. 2014.10.12 San Diego.
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Kotaro Yoshioka, Kie Tanaka, Wenying Piao, Kazutaka Nishina, Takanori Yokota.. A new class of oligonucleotide drug; DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing.. 6th TMDU International Summer Program (ISP2014). 2014.08.26
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吉岡 耕太郎, 渡邉 耕介, 日詰 正樹, 金澤 俊郎, 石橋 哲, 田中 宏明, 横田 隆徳, 水澤 英洋. 虚血性脳卒中患者における発作性心房細動に関する簡易スコア(A Simple Score For Paroxysmal Atrial Fibirillation in Ischemic Stroke Patients). 臨床神経学 2013.12.01
Patents 【 display / non-display 】
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NUCLEIC ACID WITH REDUCED TOXICITY
Patent Number: 特許第7333079号
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NUCLEIC ACID WITH REDUCED TOXICITY
Patent Number: US11851654
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DOUBLE-STRANDED NUCLEIC ACID COMPLEX HAVING OVERHANG
Patent Number: US 11260134
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DOUBLE-STRANDED ANTISENSE NUCLEIC ACID WITH EXON-SKIPPING EFFECT
Patent Number: 特許第6604544号
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DOUBLE-STRANDED ANTISENSE NUCLEIC ACID WITH EXON-SKIPPING EFFECT
Patent Number: EP3010514
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DOUBLE-STRANDED AGENTS FOR DELIVERING THERAPEUTIC OLIGONUCLEOTIDES
Patent Number: US11028387
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DOUBLE-STRANDED AGENTS FOR DELIVERING THERAPEUTIC OLIGONUCLEOTIDES
Patent Number: 3004347
Awards & Honors 【 display / non-display 】
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Dr. Alan M. Gewirtz Memorial Scholarship Award,Oligonucleotide Therapeutics Society (OTS),2021.09
Others 【 display / non-display 】
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Sweet move: a modified sugar enhances antisense oligonucleotide safety and efficacy,2024.05
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Calcium: A key player for a promising and safe brain treatment?,2023.03