Personnel Information

写真a

YOSHIOKA Kotaro


Job title

Assistant Professor

Birth date

1982

Laboratory Address

Department of Neurology and Neurological Science, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-Ku, Tokyo 113-0034, Japan.

Laboratory Phone number

+81-03-5803-5234

Laboratory Fax number

+81-03-5803-0169

Mail Address

kotanuro@tmd.ac.jp

Graduating School 【 display / non-display

  • Tokyo Medical and Dental University, Faculty of Medicine, 2007.03, Graduated

Graduate School 【 display / non-display

  • Tokyo Medical and Dental University, Graduate School, Division of Medicine, Doctor's Course, Completed

Campus Career 【 display / non-display

  • 2009.04
    -
    2010.05
    Tokyo Medical and Dental University, Medical Hospital, Hospital Departments, Department of Neurology, Neurosurgery,Psychiatry and Anesthesiology, Neurology, Senior Resident
  • 2012.04
    -
    2016.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Cognitive and Behavioral Medicine, Neurology and Neurological Science, Graduate Student
  • 2016.04
    -
    2017.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Cognitive and Behavioral Medicine, Neurology and Neurological Science, Project Assistant Professor
  • 2017.04
    -
    2018.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Cognitive and Behavioral Medicine, Neurology and Neurological Science, Project Assistant Professor
  • 2018.04
    -
    2021.02
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Cognitive and Behavioral Medicine, Neurology and Neurological Science, Project Assistant Professor

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External Career 【 display / non-display

  • 2007.04
    -
    2009.03
    , Trainee Resident
  • 2010.06
    -
    2012.03
    , Senior Resident

Research Areas 【 display / non-display

  • Other

  • Neurology

 

Published Papers & Misc 【 display / non-display

  • Kishimoto Y, Nakagawa O, Fujii A, Yoshioka K, Nagata T, Yokota T, Hari Y, Obika S. 2',4'-BNA/LNA with 9-(2-Aminoethoxy)-1,3-diaza-2-oxophenoxazine Efficiently Forms Duplexes and Has Enhanced Enzymatic Resistance*. Chemistry (Weinheim an der Bergstrasse, Germany). 2021.02; 27 (7): 2427-2438. ( PubMed, DOI )

  • Asami Y, Nagata T, Yoshioka K, Kunieda T, Yoshida-Tanaka K, Bennett CF, Seth PP, Yokota T. Efficient Gene Suppression by DNA/DNA Double-Stranded Oligonucleotide In Vivo. Molecular therapy : the journal of the American Society of Gene Therapy. 2021.02; 29 (2): 838-847. ( PubMed, DOI )

  • Lei Mon SS, Yoshioka K, Jia C, Kunieda T, Asami Y, Yoshida-Tanaka K, Piao W, Kuwahara H, Nishina K, Nagata T, Yokota T. Highly efficient gene silencing in mouse brain by overhanging-duplex oligonucleotides via intraventricular route. FEBS letters. 2020.05; 594 (9): 1413-1423. ( PubMed, DOI )

  • Yoshioka K, Kunieda T, Asami Y, Guo H, Miyata H, Yoshida-Tanaka K, Sujino Y, Piao W, Kuwahara H, Nishina K, Hara RI, Nagata T, Wada T, Obika S, Yokota T. Highly efficient silencing of microRNA by heteroduplex oligonucleotides. Nucleic acids research. 2019.08; 47 (14): 7321-7332. ( PubMed, DOI )

  • Ozaki Kokoro, Ohkubo Takuya, Yamada Tetsuo, Yoshioka Kotaro, Ichijo Masahiko, Majima Takamasa, Kudo Shunsuke, Akashi Takumi, Honda Keiji, Ito Eisaku, Watanabe Mayumi, Sekine Masaki, Hamagaki Miwako, Eishi Yoshinobu, Sanjo Nobuo, Ishibashi Satoru, Mizusawa Hidehiro, Yokota Takanori. Progressive Encephalomyelitis with Rigidity and Myoclonus Resolving after Thymectomy with Subsequent Anasarca: An Autopsy Case Internal Medicine. 2018.12; 57 (23): 3451-3458. ( ichushi )

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Books etc 【 display / non-display

  • Yoshioka K, Nishina K, Nagata T, Yokota T.. Molecular Technology: Life Innovation. Wiley-VCH, Weinheim, 2018.12 DNA/RNA Heteroduples Oligonucleotides.

Conference Activities & Talks 【 display / non-display

  • 1. Yoshioka K, Kunieda T, Asami Y, Huijia G, Miyata H, Tanaka K, Sujino Y, Piao W, Kuwahara H, Nishina K, Iwata-Hara R, Nagata T, Wada T, Obika S, Yokota T. . Heteroduplex-oligonucleotides for highly efficient silencing of microRNA through a novel intracellular mechanism. 15th Annual Meeting of the Oligonucleotide Therapeutics Society 2019.10.16

  • Mon Su Su Lei, Yoshioka Kotaro, Kunieda Taiki, Asami Yutaro, Tanaka Kie, Piao Wenying, Kuwahara Hiroya, Nishina Kazutaka, Nagata Tetsuya, Yokota Takanori. アンチセンスオリゴヌクレオチド二本鎖の新しい構造は脳室内経路を介した効果を改善する(A novel structure of duplex antisense oligonucleotides improves potency via intraventricular route). 臨床神経学 2018.12.01

  • Yoshioka Kotaro, Kunieda Taiki, Asami Yutaro, Guo Huija, Enomoto Seiya, Miyata Haruka, Tanaka Kie, Piao Wenying, Kuwahara Hiroya, Nishina Kazutaka, Nagata Tetsuya, Yokota Takanori. 新しい種類の二本鎖オリゴヌクレオチドはin vivoにおいてmicroRNAサイレンシングの効力を増強する(A new class of double-stranded oligonucleotide enhances in vivo potency of microRNA silencing). 臨床神経学 2018.12.01

  • Kotaro Yoshioka, Taiki Kunieda, Yutaro Asami, Yumiko Sujino, Kie Tanaka, Wenying Piao, Hiroya Kuwahara, Kazutaka Nishina, Tetsuya Nagata and Takanori Yokota. Dual overhanging-duplex oligonucleotide improved efficacy and safety in gene therapy for FAP. XX Ⅲ World Congress of Neurology 2017.09.20 Kyoto, JPN

  • Nishina Kazutaka, Yoshioka Kotaro, Nishina Tomoko, Kuwahara Hiroya, Nagata Tetsuya, Yokota Takanori. DNA/RNAヘテロ二本鎖構造に基づく新規オリゴヌクレオチド(Novel oligonucleotide based on DNA/RNA heteroduplex structures). 臨床神経学 2016.12.01

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Patents 【 display / non-display

  • DOUBLE-STRANDED ANTISENSE NUCLEIC ACID WITH EXON-SKIPPING EFFECT

    Patent Number: 特許第6604544号

  • DOUBLE-STRANDED AGENTS FOR DELIVERING THERAPEUTIC OLIGONUCLEOTIDES

    Patent Number: 3004347