Personnel Information

写真a

MORI Yutaro


Job title

Assistant Professor

Field Introduction URL

東京医科歯科大学 腎臓内科

Graduating School 【 display / non-display

  • Tokyo Medical and Dental University, Faculty of Medicine, 2008.03, Graduated

Graduate School 【 display / non-display

  • Tokyo Medical and Dental University, Doctor's Course, 2016.03, Completed

Degree 【 display / non-display

  • Doctor of Philosophy in Medical Science, Tokyo Medical and Dental University

  • Doctor of Medicine, Tokyo Medical and Dental University

Campus Career 【 display / non-display

  • 2002.04
    -
    2008.03
    Tokyo Medical and Dental University, Faculty of Medicine, School of Medicine, Student
  • 2009.04
    -
    2010.03
    Tokyo Medical and Dental University, (Old Organization)Medical Hospital, Central Clinical Facilities, Professional Development Center, Trainee Resident
  • 2012.04
    -
    2016.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Nephrology, Graduate Student
  • 2016.04
    -
    2019.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Nephrology, Visiting Lecturer
  • 2022.02
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Nephrology, Assistant Professor

External Career 【 display / non-display

  • 2008.04
    -
    2009.03
    , Trainee Resident
  • 2017.04
    -
    2018.03
    Harvard Medical School, Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Research Fellow in Medicine (HMS) / POI Sponsored Collaborator (BWH)
  • 2018.04
    -
    2022.01
    Harvard Medical School, Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Research Fellow in Medicine (HMS) / Research Fellow (BWH)
  • 2020.04
    -
    2022.01
    Japan Society for the Promotion of Science, Overseas Research Fellow

Academic Society Affiliations 【 display / non-display

  • THE JAPANESE SOCIETY OF INTERNAL MEDICINE

  • JAPANESE SOCIETY OF NEPHROLOGY

  • THE JAPANESE SOCIETY FOR DIALYSIS THERAPY

  • AMERICAN SOCIETY OF NEPHROLOGY

  • American Heart Association

  • The Molecular Biology Society of Japan

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Academic Activity 【 display / non-display

  • 2017.04
    -
    Now
    Japanese Society of Nephrology Councillor
  • 2020.04
    -
    Now
    The Japanese Society of Internal Medicine Committee Member of Peer Review for Clinical Summary in Board Certification Examination
  • 2022.04
    -
    Now
    Tokyo Medical and Dental University Open Innovation Promotor

Research Areas 【 display / non-display

  • Physiology

  • Clinical pharmacy

  • Medical biochemistry

  • General internal medicine

  • Nephrology

Qualification Acquired 【 display / non-display

  • Doctor

 

Research Theme 【 display / non-display

  • Elucidation of pathophysiology of diabetic kidney disease focusing on intracellular glucose metabolism, 2023.03 - 2024.04

  • Elucidation of pathophysiology of diabetic kidney disease focusing on intracellular glucose metabolism, 2023.03 - 2024.04

  • Development of treatment for diabetic kidney disease by combination of KIM-1 inhibitor and SGLT2 inhibitor, 2023.01 - 2024.12

  • Development of treatment for diabetic kidney disease by combination of KIM-1 inhibitor and SGLT2 inhibitor, 2023.01 - 2024.12

  • Development of semi-personalized disease modeling based on renal tubular organoids, 2022.08 - 2024.03

  • Development of semi-personalized disease modeling based on renal tubular organoids, 2022.08 - 2024.03

  • Development of semi-personalized disease modeling based on renal tubular organoids, 2022.08 - 2024.03

  • Drug Discovery for Chronic Kidney Disease Targeting Cellular Senescence and Immune Checkpoint Molecules, 2022.02 - 2026.03

  • Drug Discovery for Chronic Kidney Disease Targeting Cellular Senescence and Immune Checkpoint Molecules, 2022.02 - 2026.03

  • Drug Discovery for Chronic Kidney Disease Targeting Cellular Senescence and Immune Checkpoint Molecules, 2022.02 - 2026.03

  • Kidney Injury Molecule-1 in Epithelial Repair, 2021.08 - 2022.01

  • Development of new drug for diabetic kidney disease targeted at KIM-1 and free fatty acids, 2020.04 - 2022.01

  • Development of new drug for diabetic kidney disease targeted at KIM-1 and free fatty acids, 2020.04 - 2022.01

  • Development of new drug for diabetic kidney disease targeted at KIM-1 and free fatty acids, 2020.04 - 2022.01

  • Clarifications for pathophysiology of diabetic kidney disease related to KIM-1 and drug discovery, 2019.04 - 2020.03

  • Clarifications for pathophysiology of diabetic kidney disease related to KIM-1 and drug discovery, 2019.04 - 2020.03

  • Clarifications for pathophysiology of diabetic kidney disease related to KIM-1 and drug discovery, 2019.04 - 2020.03

  • Elucidation of regulatory mechanism for WNK kinase, blood pressure and electrolytes by autophagy, 2016.08 - 2017.03

  • Elucidation of regulatory mechanism for WNK kinase, blood pressure and electrolytes by autophagy, 2016.08 - 2017.03

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Published Papers & Misc 【 display / non-display

  1. Yuta Nakano, Shintaro Mandai, Shotaro Naito, Tamami Fujiki, Yutaro Mori, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Soichiro Iimori, Eisei Sohara, Shinichi Uchida. Effect of osteosarcopenia on longitudinal mortality risk and chronic kidney disease progression in older adults Bone. 2024.02; 179 116975. ( DOI )

  2. Takuya Fujimaru, Takayasu Mori, Motoko Chiga, Shintaro Mandai, Hiroaki Kikuchi, Fumiaki Ando, Yutaro Mori, Koichiro Susa, Yuta Nakano, Takao Shoji, Yuichiro Fukudome, Naoto Inaba, Kenichiro Kitamura, Taichi Nakanishi, Keiko Uchida, Toshihiro Kimura, Teiichi Tamura, Kiyoshi Ozawa, Shinichi Uchida, Eisei Sohara. Genetic diagnosis of adult hemodialysis patients with unknown etiology Kidney International Reports. 2024.01;

  3. Hisazumi Matsuki, Shintaro Mandai, Hiroki Shiwaku, Takaaki Koide, Naohiro Takahashi, Tomoki Yanagi, Shunsuke Inaba, Saaya Ida, Tamami Fujiki, Yutaro Mori, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Soichiro Iimori, Eisei Sohara, Hidehiko Takahashi, Shinichi Uchida. Chronic kidney disease causes blood-brain barrier breakdown via urea-activated matrix metalloproteinase-2 and insolubility of tau protein Aging. 2023.10; 15 (20): 10972-10995. ( PubMed, DOI )

  4. JMA Journal. Association of Admission Functional Status and Body Mass Index with Mortality in Patients Receiving Chronic Dialysis: A Nationwide Observational Cohort Study JMA Journal. 2023.10; 6 (4): 404-413. ( DOI )

  5. Hisazumi Matsuki, Taku Genma, Shintaro Mandai, Tamami Fujiki, Yutaro Mori, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Soichiro Iimori, Shotaro Naito, Eisei Sohara, Tatemitsu Rai, Kiyohide Fushimi, Shinichi Uchida. National Trends in Mortality and Urgent Dialysis after Acute Hypertension in Japan From 2010 Through 2019 Hypertension. 2023.10; 80 (12): 2591-2600. ( PubMed, DOI )

  6. Hideki Yanagawa, Yu Hara, Fumiaki Ando, Soichiro Suzuki, Tamami Fujiki, Daisuke Oikawa, Naofumi Yui, Shintaro Mandai, Yutaro Mori, Koichiro Susa, Takayasu Mori, Eisei Sohara, Fuminori Tokunaga, Shinichi Uchida. LRBA signalosomes activate vasopressin‐induced AQP2 trafficking at recycling endosomes 2023.10; 601 (23): 5437-5451. ( PubMed, DOI )

  7. Nobuhisa Morimoto, Takayasu Mori, Shingo Shioji, Hatsumi Watanabe, Keigo Sakai, Katsuo Mori, Ayumi Yamamura, Asami Hanioka, Yuichiro Akagi, Tamami Fujiki, Shintaro Mandai, Yutaro Mori, Fumiaki Ando, Koichiro Susa, Soichiro Iimori, Shotaro Naito, Eisei Sohara, Shinichi Uchida. Thrombocytopenia during avacopan administration: A case report International Journal of Rheumatic Diseases. 2023.03; 26 (8): 1603-1607. ( PubMed, DOI )

  8. Absence of ULK1 decreases AMPK activity in the kidney, leading to chronic kidney disease progression 2022.11; 28 (1): 5-14. ( DOI )

  9. Jialing Liu, Yi Li, Lingna Lyu, Liang Xiao, Aliza A Memon, Xin Yu, Arvin Halim, Shivani Patel, Abdikheyre Osman, Wenqing Yin, Jie Jiang, Said Naini, Kenneth Lim, Aifeng Zhang, Jonathan D Williams, Ruth Koester, Kevin Z Qi, Quynh-Anh Fucci, Lai Ding, Steven Chang, Ankit Patel, Yutaro Mori, Advika Chaudhari, Aaron Bao, Jia Liu, Tzong-Shi Lu, Andrew Siedlecki. Integrin α5 Is Regulated by miR-218-5p in Endothelial Progenitor Cells. J Am Soc Nephrol. 2022.03; 33 (3): 565-582. ( PubMed, DOI )

  10. Yutaro Mori, Corby Fink, Takaharu Ichimura, Keisuke Sako, Makiko Mori, Nathan N Lee, Philipp Aschauer, Krishna M Padmanabha Das, SoonGweon Hong, Minsun Song, Robert F Padera, Astrid Weins, Luke P Lee, Mahmoud L Nasr, Gregory A Dekaban, Jimmy D Dikeakos, Joseph V Bonventre. KIM-1/TIM-1 is a Receptor for SARS-CoV-2 in Lung and Kidney. medRxiv. 2022.01; 2020.09.16.20190694 ( PubMed, DOI )

  11. Christian Wiraja, Yutaro Mori, Takaharu Ichimura, Jangsun Hwang, Chenjie Xu, Joseph V Bonventre. Nephrotoxicity Assessment with Human Kidney Tubuloids using Spherical Nucleic Acid-Based mRNA Nanoflares. Nano Lett. 2021.07; 21 (13): 5850-5858. ( PubMed, DOI )

  12. Li Li, Pierre Galichon, Xiaoyan Xiao, Ana C Figueroa-Ramirez, Diana Tamayo, Jake J-K Lee, Marian Kalocsay, David Gonzalez-Sanchez, Maria S Chancay, Kyle W McCracken, Nathan N Lee, Takaharu Ichimura, Yutaro Mori, M Todd Valerius, Julia Wilflingseder, Dario R Lemos, Elazer R Edelman, Joseph V Bonventre. Orphan nuclear receptor COUP-TFII enhances myofibroblast glycolysis leading to kidney fibrosis. EMBO Rep. 2021.06; 22 (6): e51169. ( PubMed, DOI )

  13. Takuya Fujimaru, Kunio Kawanishi, Takayasu Mori, Eikan Mishima, Akinari Sekine, Motoko Chiga, Masayuki Mizui, Noriaki Sato, Motoko Yanagita, Yuki Ooki, Kiyotaka Nagahama, Yuko Ohnuki, Naoto Hamano, Saki Watanabe, Toshio Mochizuki, Katsushi Nagatsuji, Kenichi Tanaka, Tatsuo Tsukamoto, Hideo Tsushima, Mamiko Shimamoto, Takahiro Tsuji, Tamaki Kuyama, Shinya Kawamoto, Kenji Maki, Ai Katsuma, Mariko Oishi, Kouhei Yamamoto, Shintaro Mandai, Hiroaki Kikuchi, Fumiaki Ando, Yutaro Mori, Koichiro Susa, Soichiro Iimori, Shotaro Naito, Tatemitsu Rai, Junichi Hoshino, Yoshifumi Ubara, Mariko Miyazaki, Michio Nagata, Shinichi Uchida, Eisei Sohara. Genetic Background and Clinicopathologic Features of Adult-onset Nephronophthisis. Kidney Int Rep. 2021.05; 6 (5): 1346-1354. ( PubMed, DOI )

  14. Yutaro Mori, Amrendra K Ajay, Jae-Hyung Chang, Shan Mou, Huiping Zhao, Seiji Kishi, Jiahua Li, Craig R Brooks, Sheng Xiao, Heung-Myong Woo, Venkata S Sabbisetti, Suetonia C Palmer, Pierre Galichon, Li Li, Joel M Henderson, Vijay K Kuchroo, Julie Hawkins, Takaharu Ichimura, Joseph V Bonventre. KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease. Cell Metab. 2021.05; 33 (5): 1042-1061.e7. ( PubMed, DOI )

  15. Yutaro Mori, Amrendra K. Ajay, Jae-Hyung Chang, Shan Mou, Huiping Zhao, Seiji Kishi, Jiahua Li, Craig R. Brooks, Sheng Xiao, Heung-Myong Woo, Venkata S. Sabbisetti, Suetonia C. Palmer, Pierre Galichon, Li Li, Joel M. Henderson, Vijay K. Kuchroo, Takaharu Ichimura, Joseph V. Bonventre. KIM-1 Mediated Tubular Fatty Acid Uptake Leads to Progressive Diabetic Kidney Disease SSRN Electronic Journal (Sneak Peek 2.0, Cell Metabolism). 2020.07; ( DOI )

  16. Li Li;Pierre Galichon;Xiaoyan Xiao;Ana C Figueroa-Ramirez;Diana Tamayo;Jake June-Koo Lee;Marian Kalocsay;David Gonzalez-Sanchez;Maria S Chancay;Kyle McCracken;Dario Lemos;Nathan Lee;Takaharu Ichimura;Yutaro Mori;M. Todd Valerius;Xiaoming Sun;Elazer R Edelman;Joseph V Bonventre. Orphan nuclear receptor COUP-TFII drives the myofibroblast metabolic shift leading to fibrosis bioRxiv. 2020.06; 2020.06.05.135889. ( DOI )

  17. Xiaojie Wang, Jialing Liu, Wenqing Yin, Farhiya Abdi, Paul D Pang, Quynh-Anh Fucci, Molly Abbott, Steven L Chang, Graeme Steele, Ankit Patel, Yutaro Mori, Aifeng Zhang, Shikai Zhu, Tzong-Shi Lu, Adam S Kibel, Bin Wang, Kenneth Lim, Andrew M Siedlecki. miR-218 Expressed in Endothelial Progenitor Cells Contributes to the Development and Repair of the Kidney Microvasculature. Am J Pathol. 2020.03; 190 (3): 642-659. ( PubMed, DOI )

  18. Seiji Kishi, Craig R Brooks, Kensei Taguchi, Takaharu Ichimura, Yutaro Mori, Akinwande Akinfolarin, Navin Gupta, Pierre Galichon, Bertha C Elias, Tomohisa Suzuki, Qian Wang, Leslie Gewin, Ryuji Morizane, Joseph V Bonventre. Proximal tubule ATR regulates DNA repair to prevent maladaptive renal injury responses. J Clin Invest. 2019.11; 129 (11): 4797-4816. ( PubMed, DOI )

  19. T Fujimaru, T Mori, A Sekine, S Mandai, M Chiga, H Kikuchi, F Ando, Y Mori, N Nomura, S Iimori, S Naito, T Okado, T Rai, J Hoshino, Y Ubara, S Uchida, E Sohara. Kidney enlargement and multiple liver cyst formation implicate mutations in PKD1/2 in adult sporadic polycystic kidney disease. Clin Genet. 2018.07; 94 (1): 125-131. ( PubMed, DOI )

  20. Toshiyuki Makino, Yoshitatsu Ohara, Namiko Kobayashi, Yohei Kono, Ayumu Nomizu, Mariko Ichijo, Yutaro Mori, Noriaki Matsui, Dai Kishida, Takayuki Toda. Atypical familial Mediterranean fever developed in a long-term hemodialysis patient. Hemodial Int. 2018.04; 22 (2): E19-E22. ( PubMed, DOI )

  21. Wang Y,Nomura N,Zeniya M,Mori Y,Takahashi D,Naito S,Rai T,Uchida S,Sohara E. High potassium concentration regulates the WNK3–SPAK–NKCC1 phosphorylation cascade via kelch-like protein 2 in mouse vascular smooth muscle cells Journal of Medical and Dental Sciences. 2018.03; 65 (1): 35-44. ( DOI )

  22. Yuki Yoshizaki, Takayasu Mori, Mari Ishigami-Yuasa, Eriko Kikuchi, Daiei Takahashi, Moko Zeniya, Naohiro Nomura, Yutaro Mori, Yuya Araki, Fumiaki Ando, Shintaro Mandai, Yuri Kasagi, Yohei Arai, Emi Sasaki, Sayaka Yoshida, Hiroyuki Kagechika, Tatemitsu Rai, Shinichi Uchida, Eisei Sohara. Drug-Repositioning Screening for Keap1-Nrf2 Binding Inhibitors using Fluorescence Correlation Spectroscopy. Sci Rep. 2017.06; 7 (1): 3945. ( PubMed, DOI )

  23. Shintaro Mandai, Susumu Furukawa, Manami Kodaka, Yutaka Hata, Takayasu Mori, Naohiro Nomura, Fumiaki Ando, Yutaro Mori, Daiei Takahashi, Yuki Yoshizaki, Yuri Kasagi, Yohei Arai, Emi Sasaki, Sayaka Yoshida, Yasuro Furuichi, Nobuharu L Fujii, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida. Loop diuretics affect skeletal myoblast differentiation and exercise-induced muscle hypertrophy. Sci Rep. 2017.04; 7 46369. ( PubMed, DOI )

  24. Emi Sasaki, Koichiro Susa, Takayasu Mori, Kiyoshi Isobe, Yuya Araki, Yuichi Inoue, Yuki Yoshizaki, Fumiaki Ando, Yutaro Mori, Shintaro Mandai, Moko Zeniya, Daiei Takahashi, Naohiro Nomura, Tatemitsu Rai, Shinichi Uchida, Eisei Sohara. Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3. Mol Cell Biol. 2017.03; 37 (7): ( PubMed, DOI )

  25. Wakana Shoda, Naohiro Nomura, Fumiaki Ando, Yutaro Mori, Takayasu Mori, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida. Calcineurin inhibitors block sodium-chloride cotransporter dephosphorylation in response to high potassium intake. Kidney Int. 2017.02; 91 (2): 402-411. ( PubMed, DOI )

  26. Yuki Yoshizaki, Yutaro Mori, Yoshihito Tsuzaki, Takayasu Mori, Naohiro Nomura, Mai Wakabayashi, Daiei Takahashi, Moko Zeniya, Eriko Kikuchi, Yuya Araki, Fumiaki Ando, Kiyoshi Isobe, Hidenori Nishida, Akihito Ohta, Koichiro Susa, Yuichi Inoue, Motoko Chiga, Tatemitsu Rai, Sei Sasaki, Shinichi Uchida, Eisei Sohara. Impaired degradation of WNK by Akt and PKA phosphorylation of KLHL3. Biochem Biophys Res Commun. 2015.11; 467 (2): 229-234. ( PubMed, DOI )

  27. Yutaro Mori, Takayasu Mori, Mai Wakabayashi, Yuki Yoshizaki, Moko Zeniya, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida. Involvement of selective autophagy mediated by p62/SQSTM1 in KLHL3-dependent WNK4 degradation. Biochem J. 2015.11; 472 (1): 33-41. ( PubMed, DOI )

  28. Moko Zeniya, Nobuhisa Morimoto, Daiei Takahashi, Yutaro Mori, Takayasu Mori, Fumiaki Ando, Yuya Araki, Yuki Yoshizaki, Yuichi Inoue, Kiyoshi Isobe, Naohiro Nomura, Katsuyuki Oi, Hidenori Nishida, Sei Sasaki, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida. Kelch-Like Protein 2 Mediates Angiotensin II-With No Lysine 3 Signaling in the Regulation of Vascular Tonus. J Am Soc Nephrol. 2015.09; 26 (9): 2129-2138. ( PubMed, DOI )

  29. Katsuhito Ihara, Shotaro Naito, Tomokazu Okado, Tatemitu Rai, Yutaro Mori, Takayuki Toda, Shinichi Uchida, Sei Sasaki, Noriaki Matsui. Successful recovery from an acute kidney injury due to amniotic fluid embolism. Intern Med. 2015; 54 (1): 49-54. ( PubMed, DOI )

  30. Koichiro Susa, Eisei Sohara, Tatemitsu Rai, Moko Zeniya, Yutaro Mori, Takayasu Mori, Motoko Chiga, Naohiro Nomura, Hidenori Nishida, Daiei Takahashi, Kiyoshi Isobe, Yuichi Inoue, Kenta Takeishi, Naoki Takeda, Sei Sasaki, Shinichi Uchida. Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice. Hum Mol Genet. 2014.10; 23 (19): 5052-5060. ( PubMed, DOI )

  31. Katsuhito Ihara, Shotaro Naito, Wakaba Yamaguchi, Yutaro Mori, Takayuki Toda, Tatemitsu Rai, Shinichi Uchida, Sei Sasaki, Noriaki Matsui. Hepatic cyst infection in an autosomal dominant polycystic kidney disease patient diagnosed by right pleural effusion. Intern Med. 2014; 53 (12): 1355-1359. ( PubMed, DOI )

  32. Yutaro Mori, Mai Wakabayashi, Takayasu Mori, Yuya Araki, Eisei Sohara, Tatemitsu Rai, Sei Sasaki, Shinichi Uchida. Decrease of WNK4 ubiquitination by disease-causing mutations of KLHL3 through different molecular mechanisms. Biochem Biophys Res Commun. 2013.09; 439 (1): 30-34. ( PubMed, DOI )

  33. Daiei Takahashi, Takayasu Mori, Mai Wakabayashi, Yutaro Mori, Koichiro Susa, Moko Zeniya, Eisei Sohara, Tatemitsu Rai, Sei Sasaki, Shinichi Uchida. KLHL2 interacts with and ubiquitinates WNK kinases. Biochem Biophys Res Commun. 2013.08; 437 (3): 457-462. ( PubMed, DOI )

  34. Mai Wakabayashi, Takayasu Mori, Kiyoshi Isobe, Eisei Sohara, Koichiro Susa, Yuya Araki, Motoko Chiga, Eriko Kikuchi, Naohiro Nomura, Yutaro Mori, Hiroshi Matsuo, Tomohiro Murata, Shinsuke Nomura, Takako Asano, Hiroyuki Kawaguchi, Shigeaki Nonoyama, Tatemitsu Rai, Sei Sasaki, Shinichi Uchida. Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension. Cell Rep. 2013.03; 3 (3): 858-868. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  1. Takayasu Mori, Takuya Fujimaru, Chunyu Liu, Karynne Patterson, Kohei Yamamoto, Takefumi Suzuki, Motoko Chiga, Shintaro Mandai, Fumiaki Ando, Yutaro Mori, Koichiro Susa, Yue-Qiu Tan, Feng Zhang, Shinichi Uchida, Eisei Sohara. Discovery of a Novel Candidate Gene Implicated in X-Linked Polycystic Kidney Disease. Kidney Week 2023 2023.11.04

  2. Yuki Nakao, Yutaro Mori, Makiko Mori, Shintaro Mandai, Tamami Fujiki, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Eisei Sohara, Shinichi Uchida. Tubuloids on Primary Human Renal Tubular Epithelial Cells (hRTECs) Recapitulates Cisplatin-Induced Kidney Injury. Kidney Week 2023 2023.11.04 Philadelphia

  3. Amrendra K. Ajay, Yutaro Mori, Venkata Sabbisetti, Joseph V. Bonventre. Screening for Small-Molecule Inhibitor for KIM-1 and Its Functional Validation in Kidney Fibrosis. Kidney Week 2023 2023.11.04

  4. Takuya Fujimaru, Takayasu Mori, Motoko Chiga, Shintaro Mandai, Yu Hara, Tamami Fujiki, Hiroaki Kikuchi, Yutaro Mori, Fumiaki Ando, Koichiro Susa, Soichiro Iimori, Shotaro Naito, Shinichi Uchida, Eisei Sohara.. Monoallelic IFT140 Pathogenic Variants in Adult Polycystic Kidney Disease Patients Without Family History.. ASN Kidney Week 2023 2023.11.04 Philadelphia

  5. Makiko Mori, Yutaro Mori, Corby Fink, Takaharu Ichimura, Keisuke Sako, Yuki Nakao, Astrid Weins, Shinichi Uchida, Joseph V. Bonventre. Kidney Injury Molecule-1 Is an Independent Receptor from ACE2 for SARS-CoV-2 in Lung and Kidney. Kidney Week 2023 2023.11.03 Philadelphia

  6. Yu Hara, Fumiaki Ando, Hideki Yanagawa, Soichiro Suzuki, Tamami Fujiki, Shintaro Mandai, Yutaro Mori, Koichiro Susa, Takayasu Mori, Eisei Sohara, Shinichi Uchida.. LRBA Signalosomes Activate Vasopressin-Induced AQP2 Trafficking at Recycling Endosomes.. ASN Kidney Week 2023 2023.11.03 Philadelphia

  7. Shunsuke Inaba, Shintaro Mandai, Yuta Nakano, Hisazumi Matsuki, Tamami Fujiki, Yutaro Mori, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Soichiro Iimori, Shotaro Naito, Eisei Sohara, Shinichi Uchida.. The Transcriptomic Landscape of microRNAs Encapsulated in Circulating Extracellular Vesicles and CKD Progression in Japanese Adults.. ASN Kidney Week 2023 2023.11.03 Philadelphia

  8. Yuta Nakano, Shintaro Mandai, Shotaro Naito, Tamami Fujiki, Yutaro Mori, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Soichiro Iimori, Eisei Sohara, Shinichi Uchida.. Association Among Bone Mass, Muscle Mass and Strength, Mortality, and CKD Progression in Older Adults.. ASN Kidney Week 2023 2023.11.02 Philadelphia

  9. Takayasu Mori, Takuya Fujimaru, Chunyu Liu, Karynne Patterson, Kohei Yamamoto, Takefumi Suzuki, Motoko Chiga, Shintaro Mandai, Fumiaki Ando, Yutaro Mori, Koichiro Susa, University of Washington Center for Rare Disease Research, Yue-Qiu Tan, Feng Zhang, Shinichi Uchida, Eisei Sohara. Discovery of a Novel Candidate Gene Implicated in X-Linked Polycystic Kidney Disease. ASN Kidney Week 2023 2023.11 Philadelphia

  10. Makiko Mori, Yutaro Mori, Takaharu Ichimura, Keisuke Sako, Shinichi Uchida, Joseph V. Bonventre. Kidney Injury Molecule-1 (KIM-1) is a Receptor for SARS-CoV-2 in Lung and Kidney. 第66回日本腎臓学会学術総会 2023.06.10 横浜

  11. Hisazumi Matsuki, Shintaro Mandai, Takaaki Koide, Naohiro Takahashi, Tomoki Yanagi, Tamami Fujiki, Yutaro Mori, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Soichiro Iimori, Eisei Sohara, Shinichi Uchida. A brain proteomic signature of chronic kidney disease uncovers blood-brain barrier breakdown via urea-activated matrix metalloproteinase-2. 第66回日本腎臓学会学術総会 2023.06.09 横浜

  12. Yuta Nakano, Shintaro Mandai, Shotaro Naito, Tamami Fujiki, Yutaro Mori, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Soichiro Iimori, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida. Impact of Osteosarcopenia on Mortality and CKD Progression: A Prospective Observational Cohort Study. 第66回日本腎臓学会学術総会 2023.06.09 横浜

  13. Underlying Genetic Causes of Adult Patients With ESKD Undergoing Hemodialysis Therapy. 2022.11.05

  14. Kidney Injury Molecule-1 (KIM-1) Shapes the Kidney Immune Microenvironment via Lymphotoxin Beta Receptor (LTbR) Signaling. 2022.11.04

  15. Small Molecule Screening Identifies TW-37 as a KIM-1 Inhibitor and Potential Anti-Fibrotic Molecule. 2022.11.03

  16. MORI Yutaro. KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease. 第26回日本心血管内分泌代謝学会学術総会 2022.10.12 京都

  17. Yutaro Mori, Seiji Kishi, Takaharu Ichimura, Joseph V. Bonventre. Kidney Injury Molecule-1 (KIM-1)-mediated Proximal Tubular (PT) Uptake of Fatty Acid (FA)-Albumin Leads to Progressive Diabetic Kidney Disease (DKD). 第64回日本腎臓学会学術総会 2021.06.18 横浜、オンライン

  18. Yutaro Mori. KIM-1/TIM-1 is a Receptor/Attachment Factor for SARS-CoV-2 in Lung and Kidney. Basic Science Research Seminar, Renal Division, Brigham and Women's Hospital, Harvard Medical School 2021.02.03 ボストン

  19. Yutaro Mori, Amrendra K. Ajay, Ankit B. Patel, Andrew M. Siedlecki, Seiji Kishi, Takaharu Ichimura, Joseph V. Bonventre. Inhibition of KIM-1-Mediated Fatty Acid Uptake by a Novel Inhibitor Attenuates Pro-Fibrotic Responses in Multiple Models of Human Primary Kidney Epithelial Cells Including Kidney Tubuloids. Kidney Week 2020 (The 53rd Annual Meeting of the American Society of Nephrology) 2020.10.22 オンライン開催

  20. Takaharu Ichimura, Mahmoud L. Nasr, Samuel Mon-Wei Yu, Yutaro Mori, Joseph V. Bonventre. Kidney Injury Molecule 1 Is a Receptor for SARS-CoV-2. Kidney Week 2020 (The 53rd Annual Meeting of the American Society of Nephrology) 2020.10.22 オンライン開催

  21. Li J, Chang JH, Suzuki T, Yang C, Mori Y, Yamashita M, Sabbisetti V, Ichimura T, Bonventre JV. Altered Citrate Metabolism Leads to Maladaptive Repair After Tubular Injury and Facilitates Kidney Fibrosis in Diabetic Nephropathy. The 52nd Annual Meeting of the American Society of Nephrology. 2019.11.09 Washington, DC

  22. Mori Y, Ichimura T, Patel AB, Siedlecki AM, Bonventre JV. Protocol to Make Renal Tubuloids from Human Kidneys. The 52nd Annual Meeting of the American Society of Nephrology. 2019.11.09 Washington, DC

  23. Yang M, Mori Y, Murakami N, Ichimura T, Bonventre JV. Kidney Injury Molecule-1 (KIM-1) Promotes Tertiary Lymphoid Tissue (TLT) Development in the Kidney Through LTaβ/LTβR Signaling. The 52nd Annual Meeting of the American Society of Nephrology. 2019.11.08 Washington, DC

  24. Mori Y, Ajay AK, Chang JH, Zhao H, Kishi S, Li J, Galichon P, Brooks CR, Xiao S, Sabbisetti V, Palmer S, Henderson JM, Ichimura T, Bonventre JV. Proximal Tubular Uptake of Free Fatty Acid (FFA) by Kidney Injury Molecule-1 (KIM-1) Mediates Tubulointerstitial Damage in Diabetic Kidney Disease (DKD), Which Is Attenuated by a Novel Inhibitor. The 52nd Annual Meeting of the American Society of Nephrology. 2019.11.08 Washington, DC

  25. Fujimaru T, Mori T, Nagata M, Mandai S, Chiga M, Kikuchi H, Ando F, Mori Y, Susa K, Isobe K, Iimori S, Nomura N, Naito S, Okado T, Rai T, Uchida S, Sohara E. Tubular Basement Membrane Duplication and Cell Interposition Are Distinctive Histological Findings in the Adult Patients Genetically Diagnosed with Nephronophthisis-Related Ciliopathies. The 52nd Annual Meeting of the American Society of Nephrology. 2019.11.08 Washington, DC

  26. MORI Yutaro. Proximal tubular uptake of free fatty acids (FFAs) by KIM-1 mediates tubulointerstitial disease in diabetic kidney disease. 次世代腎研究アカデミー2019学術集会 2019.08.17 東京

  27. MORI Yutaro. The endocytotic uptake of free fatty acid by KIM-1 causes tubulointerstitial damage in diabetic kidney disease. Boston/Harvard Cell Death Initiative Seminar Series 2019.06.03 ボストン

  28. MORI Yutaro. KIM-1 - the New Therapeutic Target for Diabetic Nephropathy. Basic Science Research Seminar, Renal Division, Brigham and Women's Hospital, Harvard Medical School 2018.11.07 ボストン

  29. Fujimaru T, Mori T, Mandai S, Chiga M, Kikuchi H, Ando F, Mori Y, Susa K, Isobe K, Iimori S, Nomura N, Naito S, Okado T, Rai T, Nagatsuji K, Nagahama K, Mishima E, Mochizuki T, Sekine A, Hoshino J, Ubara Y, Uchida S, Sohara E. Genomic Background of Adults with Suspected Ciliopathy on Renal Biopsy. The 51st Annual Meeting of the American Society of Nephrology. 2018.10.01 San Diego

  30. Mori Y, Chang JH, Mou S, Zhao H, Li J, Galichon P, Brooks CR, Xiao S, Sabbisetti VS, Palmer S, Kuchroo VK, Ichimura T, Bonventre JV. Proximal Tubular Uptake of Free Fatty Acid (FFA) by Kidney Injury Molecule-1 (KIM-1) Mediates Tubulointerstitial Disease in Diabetic Mice. The 51st Annual Meeting of the American Society of Nephrology. 2018.10.01 San Diego

  31. Mori Y, Chang JH, Mou S, Zhao H, Li J, Galichon P, Brooks CR, Xiao S, Woo HM, Sabbisetti VS, Palmer S, Henderson JM, Kuchroo VK, Ichimura T, Bonventre JV. Proximal tubular uptake of free fatty acid (FFA) by Kidney Injury Molecule-1 (KIM-1) mediates tubulointerstitial disease in diabetic nephropathy (DN). Cardio-Renal Research Symposium and Poster Session, Brigham and Women's Hospital 2018.05.01 Boston

  32. Fujimaru T, Mori T, Sekine A, Mandai S, Chiga M, Kikuchi H, Ando F, Mori Y, Nomura N, Naito S, Okado T, Rai T, Hoshino J, Ubara Y, Uchida S, Sohara E. Genomic Background of Adult Polycystic Kidney Disease Patients without a Family History. The 50th Annual Meeting of the American Society of Nephrology 2017.11.01 New Orleans

  33. Mori Y, Galichon P, Brooks CR, Ichimura T, Bonventre JV. Kidney Injury Molecule-1 (KIM-1) Mediates the Proximal Tubule Uptake of Free Fatty Acids (FFA) Resulting in Mitochondrial Injury and the DNA Damage Response (DDR). The 50th Annual Meeting of the American Society of Nephrology 2017.11.01 New Orleans

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Awards & Honors 【 display / non-display

  • Yutaro Mori. Medical Research Encouragement Prize of The Japan Medical Association,Japan Medical Association,2023.11

  • Yutaro Mori. 2022 Tokyo Medical Association Medical Research Award Encouragement Award,Tokyo Medical Association,2023.03

  • Yutaro Mori. Young Investigator Award,Japanese Society of Nephrology,2022.06

  • Yutaro Mori. The 35th Research Excellence Award,Tokyo Medical and Dental University Medical Alumni Association,2022.03

  • Yutaro Mori. 2021 Medical Association Award,Tokyo Medical and Dental University Medical Association,2022.02

  • Cardio-Renal Research Award,Brigham and Women's Hospital,2018.05

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Campus class subject 【 display / non-display

  • Clinical Clerkship,2022 - Now

  • Regulation of Body Fluid and Urology,2022 - Now

  • Medical Introductory Course,2022 - 2023

Social Contribution 【 display / non-display

  • Yutaro Mori. Peer Review for Physiology,American Physiological Society,2023.12.03 - 2024.01.04

  • Yutaro Mori. Peer Review for Frontiers in Bioscience-Landmark,IMR Press,2023.11.01 - 2024.01.25

  • Yutaro Mori. Peer Review for Biomedicine & Pharmacotherapy,Elsevier,2023.09.03

  • Yutaro Mori. Peer review for Frontiers in Pharmacology,Frontiers,2022.02.04

  • Yutaro Mori. Zeroing in on the Role of KIM-1 in Diabetic Kidney Disease,National Institute of Diabetes and Digestive and Kidney Diseases,NIDDK Recent Advances & Emerging Opportunities,Kidney, Urologic, and Hematologic Diseases,2022.01

  • Peer review for Journal of Zhejiang University-SCIENCE B,Zhejiang University Press and Springer Science+Business Media,2021.10.21 - 2022.01.19

  • Peer review for In Vitro Cellular & Developmental Biology - Animal,Springer Science+Business Media,2021.07.06 - 2021.08.18

  • Peer review for Kidney360,American Society of Nephrology,2020.07 - 2021.10

  • Science Explorers Group, Tsuchiura First High School,Tsuchiura First High School, Leave a Nest Co., Ltd.,2019.03

  • Peer Review of Articles for Scientific Reports,Nature Research,2017.12 - 2021.04

  • University-High school collaboration between Tokyo Medical and Dental University and Tsuchiura First High School,Tokyo Medical and Dental University, Tsuchiura First High School,2014.08

  • University-High school collaboration between Tokyo Medical and Dental University and Tsuchiura First High School,Tokyo Medical and Dental University, Tsuchiura First High School,2012.08

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