Personnel Information

写真a

HIBIYA Shuji


Job title

Assistant Professor
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Campus Career 【 display / non-display 】

  • 2012.04
    -
    2016.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Systemic Organ Regulation， Gastroenterology and Hepatology， Graduate Student
  • 2016.04
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    2017.03
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Internal Medicine， Gastroenterology and Hepatology， Technical Staff
  • 2018.04
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    2019.10
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Internal Medicine， Gastroenterology and Hepatology， Project Assistant Professor
  • 2019.11
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    2020.03
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Internal Medicine， Gastroenterology and Hepatology， Project Assistant Professor
  • 2020.04
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    2021.09
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Central Clinical Facilities， Endoscopy， Project Assistant Professor
  • 2021.10
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    2022.03
    Tokyo Medical and Dental University， Tokyo Medical and Dental University， Division of Clinical Medicine， Department of Specialized Medical Care， Endoscopy， Project Assistant Professor
  • 2022.04
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    2023.03
    Tokyo Medical and Dental University， Tokyo Medical and Dental University， Division of Clinical Medicine， Department of Specialized Medical Care， Endoscopy， Project Assistant Professor
  • 2023.04
    -
    Now
    Tokyo Medical and Dental University， Tokyo Medical and Dental University， Division of Clinical Medicine， Department of Specialized Medical Care， Endoscopy， Assistant Professor

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Published Papers & Misc 【 display / non-display 】

  1. Shuji Hibiya, Kiichiro Tsuchiya, Ryohei Hayashi, Keita Fukushima, Nobukatsu Horita, Sho Watanabe, Tomoaki Shirasaki, Ryu Nishimura, Natsuko Kimura, Tatsunori Nishimura, Noriko Gotoh, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Long-term Inflammation Transforms Intestinal Epithelial Cells of Colonic Organoids. J Crohns Colitis. 2017.05; 11 (5): 621-630. ( PubMed, DOI )

  2. Shuji Hibiya, Yusuke Matsuyama, Toshimitsu Fujii, Chiaki Maeyashiki, Eiko Saito, Kimiko Ito, Hiromichi Shimizu, Ami Kawamoto, Maiko Motobayashi, Kento Takenaka, Masakazu Nagahori, Masayuki Kurosaki, Tsunehito Yauchi, Kazuo Ohtsuka, Takeo Fujiwara, Ryuichi Okamoto, Mamoru Watanabe. 5-aminosalicylate-intolerant patients are at increased risk of colectomy for ulcerative colitis. Aliment Pharmacol Ther. 2021.01; 53 (1): 103-113. ( PubMed, DOI )

  3. Ami Kawamoto, Kento Takenaka, Shuji Hibiya, Yoshio Kitazume, Hiromichi Shimizu, Toshimitsu Fujii, Eiko Saito, Kazuo Ohtsuka, Ryuichi Okamoto. Combination of leucine-rich alpha-2 glycoprotein and fecal markers detect Crohn's disease activity confirmed by balloon-assisted enteroscopy. Intest Res. 2023.11; Online ahead of print ( PubMed, DOI )

  4. Shuji Hibiya, Takashi Fujii, Toshimitsu Fujii, Shinji Suzuki, Mayumi Kondo, Shinya Ooka, Yohei Furumoto, Seishin Azuma, Kei Tanaka, Hitoshi Kurata, Shohei Tanaka, Masayuki Kurosaki, Kazuyoshi Nagayama, Fumihiko Kusano, Yasuhiro Iizuka, Takahiro Kawamura, Hidekazu Ikemiyagi, Shinya Sakita, Tsunehito Yauchi, Hideki Watanabe, Ami Kawamoto, Yusuke Matsuyama, Kazuo Ohtsuka, Ryuichi Okamoto. COVID-19 severity is associated with the risk of gastrointestinal bleeding. BMJ Open Gastroenterol. 2023.11; 10 (1): ( PubMed, DOI )

  5. Kento Takenaka, Ami Kawamoto, Yoshio Kitazume, Toshimitsu Fujii, Yumi Udagawa, Hiromichi Shimizu, Shuji Hibiya, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe, Ryuichi Okamoto. Transmural Remission Characterized by High Biologic Concentrations Demonstrates Better Prognosis in Crohn's Disease. J Crohns Colitis. 2023.06; 17 (6): 855-862. ( PubMed, DOI )

  6. Kento Takenaka, Yoshio Kitazume, Ami Kawamoto, Toshimitsu Fujii, Yumi Udagawa, Ryosuke Wanatabe, Hiromichi Shimizu, Shuji Hibiya, Masakazu Nagahori, Kazuo Ohtsuka, Hiroyuki Sato, Akihiro Hirakawa, Mamoru Watanabe, Ryuichi Okamoto. Serum Leucine-Rich α2 Glycoprotein: A Novel Biomarker for Transmural Inflammation in Crohn's Disease. Am J Gastroenterol. 2023.06; 118 (6): 1028-1035. ( PubMed, DOI )

  7. Fujiwara S, Kawamoto A, Motobayashi M, Hibiya S, Takenaka K, Shimizu H, Saito E, Fujii T, Nagahori M, Kawata D, Umezawa N, Hosoya T, Yasuda S, Ohtsuka K, Okamoto R. Hemorrhagic gastric ulcer in a patient with Behcet's disease successfully treated with infliximab. DEN open. 2023.04; 3 (1): e196. ( PubMed, DOI )

  8. Eiko Saito, Kazuo Ohtsuka, Ami Kawamoto, Toshimitsu Fujii, Kento Takenaka, Shuji Hibiya, Hiromichi Shimizu, Masakazu Nagahori, Shohei Tomii, Ryuichi Okamoto. A case of venous stasis colitis possibly caused by eplerenone. Clin J Gastroenterol. 2023.02; 16 (1): 69-72. ( PubMed, DOI )

  9. Shuji Hibiya, Kazuo Ohtsuka, Kento Takenaka, Ami Kawamoto, Yusuke Matsuyama, Yumi Udagawa, Maiko Motobayashi, Hiromichi Shimizu, Toshimitsu Fujii, Eiko Saito, Masakazu Nagahori, Ryuichi Okamoto, Mamoru Watanabe. Mucosal healing of small intestinal stricture is associated with improved prognosis post-dilation in Crohn's disease. BMC Gastroenterol. 2022.05; 22 (1): 218. ( PubMed, DOI )

  10. Hiromichi Shimizu, Toshimitsu Fujii, Kenji Kinoshita, Ami Kawamoto, Shuji Hibiya, Kento Takenaka, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe, Ryuichi Okamoto. Intravenous tacrolimus is a superior induction therapy for acute severe ulcerative colitis compared to oral tacrolimus. BMC Gastroenterol. 2021.12; 21 (1): 494. ( PubMed, DOI )

  11. Hiromichi Shimizu, Toshimitsu Fujii, Shuji Hibiya, Maiko Motobayashi, Kohei Suzuki, Kento Takenaka, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe. Rapid prediction of 1-year efficacy of tofacitinib for treating refractory ulcerative colitis. Intest Res. 2020.06; Online ahead of print.. ( PubMed, DOI )

  12. Kento Takenaka, Toshimitsu Fujii, Kohei Suzuki, Hiromichi Shimizu, Maiko Motobayashi, Shuji Hibiya, Eiko Saito, Masakazu Nagahori, Mamoru Watanabe, Kazuo Ohtsuka. Small Bowel Healing Detected by Endoscopy in Patients With Crohn's Disease After Treatment With Antibodies Against Tumor Necrosis Factor. Clin. Gastroenterol. Hepatol.. 2019.08; ( PubMed, DOI )

  13. Sho Watanabe, Kiichiro Tsuchiya, Ryu Nishimura, Tomoaki Shirasaki, Nobuhiro Katsukura, Shuji Hibiya, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Mutation by CRISPR System Enhances the Malignant Potential of Colon Cancer. Mol. Cancer Res.. 2019.04; ( PubMed, DOI )

  14. Ryu Nishimura, Tomoaki Shirasaki, Kiichiro Tsuchiya, Yoshihide Miyake, Yusuke Watanabe, Shuji Hibiya, Sho Watanabe, Tetsuya Nakamura, Mamoru Watanabe. Establishment of a system to evaluate the therapeutic effect and the dynamics of an investigational drug on ulcerative colitis using human colonic organoids. J. Gastroenterol.. 2019.01; ( PubMed, DOI )

  15. Ryohei Hayashi, Kiichiro Tsuchiya, Keita Fukushima, Nobukatsu Horita, Shuji Hibiya, Keisuke Kitagaki, Mariko Negi, Eisaku Itoh, Takumi Akashi, Yoshinobu Eishi, Eriko Okada, Akihiro Araki, Kazuo Ohtsuka, Shinji Fukuda, Hiroshi Ohno, Ryuichi Okamoto, Tetsuya Nakamura, Shinji Tanaka, Kazuaki Chayama, Mamoru Watanabe. Reduced Human α-defensin 6 in Noninflamed Jejunal Tissue of Patients with Crohn's Disease. Inflamm. Bowel Dis.. 2016.05; 22 (5): 1119-1128. ( PubMed, DOI )

  16. Keita Fukushima, Kiichiro Tsuchiya, Yoshihito Kano, Nobukatsu Horita, Shuji Hibiya, Ryohei Hayashi, Keisuke Kitagaki, Mariko Negi, Eisaku Itoh, Takumi Akashi, Yoshinobu Eishi, Shigeru Oshima, Takashi Nagaishi, Okamoto Ryuichi, Tetsuya Nakamura, Mamoru Watanabe. Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line. Cancer Sci. 2015.05; 106 (8): 1000-1007. ( PubMed, DOI )

  17. Nobukatsu Horita, Kiichiro Tsuchiya, Ryohei Hayashi, Keita Fukushima, Shuji Hibiya, Masayoshi Fukuda, Yoshihito Kano, Tomohiro Mizutani, Yasuhiro Nemoto, Shiro Yui, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Fluorescent labelling of intestinal epithelial cells reveals independent long-lived intestinal stem cells in a crypt. Biochem Biophys Res Commun. 2014.10; 454 (4): 493-499. ( PubMed, DOI )

  18. Tatsuro Murano, Ryuichi Okamoto, Go Ito, Toru Nakata, Shuji Hibiya, Hiromichi Shimizu, Satoru Fujii, Yoshihito Kano, Tomohiro Mizutani, Shiro Yui, Junko Akiyama-Morio, Yasuhiro Nemoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells. Biochem Biophys Res Commun. 2014.01; 443 (3): 840-846. ( PubMed, DOI )

  19. Yoshihito Kano, Kiichiro Tsuchiya, Xiu Zheng, Nobukatsu Horita, Keita Fukushima, Shuji Hibiya, Yuhki Yamauchi, Tatsunori Nishimura, Kunihiko Hinohara, Noriko Gotoh, Shinji Suzuki, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein. Biochem. Biophys. Res. Commun.. 2013.03; 432 (1): 175-181. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. T. Fujii , S. Hibiya , H. Shimizu , A. Kawamoto , K. Takenaka , E. Saito , M. Nagahori , K. Ohtsuka , R. Okamoto. DUAL THERAPY WITH CAROTEGRAST (AJM300: ORAL α4 INTEGRIN ANTAGONIST) AND BIOLOGICS FOR REFRACTORY ULCERATIVE COLITIS. UEGW2023 2023.10.15

  2. A. Kawamoto, K. Takenaka, S. Hibiya, Y. Kitazume, K. Ito, H. Shimizu, T. Fujii, E. Saito, K. Ohtsuka, R. Okamoto. COMBINING LEUCINE-RICH ALPHA-2 GLYCOPROTEIN AND FAECAL BIOMARKERS FOR ACCURATE MONITORING OF SMALL BOWEL ACTIVITY IN CROHN’S DISEASE. UEG Week 2023.10.14

  3. Shuij Hibiya, Takashi Fujii, Toshimitsu Fujii, Kazuo Ohtsuka, Ryuichi Okamoto. Severe COVID-19 is associated with risk of lower gastrointestinal bleeding. UEG Week 2023 2023.10.14

  4. Shuji Hibiya, Kazuo Ohtsuka, Ryuichi Okamoto. Association between mucosal healing and surgery risk after endoscopic balloon dilatation for small intestinal stricture of Crohn's disease. JDDW2021 2021.11.06 神戸コンベンションセンター(兵庫)

  5. 土屋輝一郎、長堀正和、日比谷秀爾、竹中健人、河本亜美、清水寛路、藤井俊光、齊藤詠子、大塚和朗、渡辺　守、岡本隆一 . 【誌面発表】COVID-19蔓延下におけるスマートデバイスを用いたIBD病診連携に関する研究. 厚生労働科学研究費 難治性疾患政策研究事業 「難治性炎症性腸管障害に関する調査研究」令和3年度 第1回総会 2021.07.15 Web開催

  6. 勝倉暢洋、日比谷秀爾、土屋輝一郎. The role of intestinal differentiation system in carcinogenesis of IPMN. 第79回日本癌学会学術総会 2020.10.01 Web開催

  7. Toshimitsu Fujii, Shuji Hibiya, Chiaki Maeyashiki, Eiko Saito, Kento Takenaka, Maiko Motobayashi, Hiromichi Shimizu, Masakazu Nagahori, Kazuo Ohtsuka, Masayuki Kurosaki, Tsunehito Yauchi, Mamoru Watanabe. Intolerance to 5-aminosalicylate is a risk of poor prognosis in Ulcerative colitis patients.. ECCO2020 2020.02.14 Vienna（Austria）

  8. 藤井俊光、日比谷秀爾、齊藤詠子、竹中健人、清水寛路、長堀正和、大塚和朗、黒崎雅之、矢内常人、泉 並木、渡辺 守. 潰瘍性大腸炎における5ASA不耐は予後不良因子となる. 日本消化器病関連学会週間(JDDW)2019 2019.11.21 神戸コンベンションセンター

  9. Shuji Hibiya, Kiichiro Tsuchiya, Ryu Nishimura, Sho Watanabe, Nobuhiro Katsukura, Tomoaki Shirasaki, Ryuichi Okamoto, Mamoru Watanabe. Establishment of chronic inflammation model using human small intestinal and colonic organoids. UEG Week 2019 2019.10.23 Barcelona（Spain）

  10. Eiko Saito, Kohei Suzuki, Shuuji Hibiya, Maiko Motobayashi, Kento Takenaka, Nobukatsu Horita, Hiromichi Shimizu, Michio Onizawa, Toshimitsu Fujii, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe. The clinical efficacy of ustekinumab (UST) in patients with Crohn’s disease (CD). AOCC2019 2019.06.15 台北

  11. Kento Takenaka, Kazuo Ohtsuka, Toshimitsu Fujii, Kohei Suzuki, Hiromichi Shimizu, Maiko Motobayashi, Shuji Hibiya, Eiko Saito, Masakazu Nagahori, Mamoru Watanabe. Small bowel endoscopic healing of Crohn’s disease treated with anti-TNF antibodies. The 7th Annual Meeting of Asian Organization for Crohn's and Colitis (AOCC 2019) 2019.06.15 台北

  12. Shuji Hibiya, Kiichiro Tsuchiya, Ryu Nishimura, Tomoaki Shirasaki, Sho Watanabe, Nobuhiro Katsukura, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Long-term inflammation model using human colonic organoids. AOCC2019 2019.06.15 Taipei（Taiwan）

  13. Tsuchiya K, Watanabe S, Shirasaki T, Nishimura R, Katsukura N, Hibiya S, Okamoto R, Nakamura T, Watanabe M. TP53 mutation in human colonic organoids acquires resistance to in vitro long-term inflammation.. ECCO2019 2019.03.09 Copenhagen（Denmark）

  14. Shuji Hibiya, Kiichiro Tsuchiya, Ryu Nishimura, Tomoaki Shirasaki, Sho Watanabe, Nobuhiro Katsukura, Tetsuya Nakamura, Mamoru Watanabe. Establishment of an in vitro system to evaluate the therapeutic effect of the investigational drug on ulcerative colitis using human colonic organoids.. ECCO2019 2019.03.08 Copenhagen（Denmark）

  15. Hibiya S, Tsuchiya K, Nishimura R, Shirasaki T, Watanabe S, Katsukura N, Okamoto R, Nakamura T, Watanabe M. Lesion-specific gene expression in the Epithelial cells of Crohn’s disease by comparing Small intestinal organoids from active and inactive Lesion in the same patient. UEGW 2018 2018.10.22 Vienna（Austria）

  16. Watanabe S, Tsuchiya K, Shirasaki T, Hibiya S, Nishimura S, Katsukura N, Oshima S, Okamoto R, Tetsuya N, Watanabe M. Tp53 mutation enhances cell proliferation and stemness in human colon epithelial organoids and promotes a resistance against long-term inflammation. UEGW 2018 2018.10.22 Vienna（Austria）

  17. Hibiya S, Tsuchiya K, Watanabe S, Nishimura R, Shirasaki T, Oshima S, Okamoto R, Nakamura T, Watanabe M. Human colonic organoid treated with inflammatory factors might mimic the pathophysiology of epithelial cells in ulcerative colitis. DDW2018 2018.06.05 Washington D.C (USA）

  18. Shirasaki T, Tsuchiya K, Nishimura R, Watanabe S, Hibiya S, Katsukura N, Okamoto R, Nakamura T, Watanabe M.. Identification of lesion-specific epithelial function of ulcerative colitis by comparing colonic organoids from lesion and non-lesion parts of same patients.. DDW2018 2018.06.05

  19. Nishimura R, Tsuchiya K, Shirasaki T, Watanabe S, Hibiya S, Okamoto R, Nakamura T, Watanabe M.. The identification of lesion-specific gene expression in intestinal epithelial cells of Ulcerative Colitis by comparing colonic organoids from lesion and non-lesion parts of same patients.. The 13th Congress of ECCO 2018.02.16 Vienna

  20. Hibiya S, Tsuchiya K, Watanabe S, Nishimura R, Shirasaki T, Oshima S, Okamoto R, Nakamura T, Watanabe M. Establishment of in vitro human model for Ulcerative Colitis by using human colon organoid culture. 13th Congress of ECCO 2018.02.16 Vienna（Austria）

  21. S. Watanabe K. Tsuchiya T. Shirasaki S. Hibiya S. Ooshima T. Nakamura R. Nishimura R. Okamoto M. Watanabe. TP53 mutation acquires higher malignant potential in human colon cancer cells. UEGW2017 (欧州消化器病学会週間2017） 2017.11.01 Barcelona(Spain)

  22. Tsuchiya K, Hibiya S, Fukushima K, Shirasaki T, Oshima S, Okamoto R, Nakamura T, Watanabe M. Atoh1 protein stabilization in colon tumor acquires the　morphological change to signet ring cell carcinoma with cancer stem cell enrichment. APDW2016 2016.11.03 Kobe convention center, KOBE（JAPAN）

  23. Hibiya S, Tsuchiya K, Watanabe S, Shirasaki T, Oshima S, Okamoto R, Nakamura T, Watanabe M. Construction of in vitro model of ulcerative colitis using mouse primary colonic organoid.. UEGW2016 2016.10.18 Vienna（Austria）

  24. Kiichiro Tsuchiya, Shuji Hibiya, Keita Fukushima, Tomoaki Shirasaki, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Atoh1 protein stabilization in colon tumor acquires the phenotype of signet ring cell carcinoma with cancer stem cell enrichment.. AOCC2016 2016.07.08 Kyoto International Conference Center, Kyoto（JAPAN）

  25. Shuji Hibiya, Kiichiro Tsuchiya, Tomoaki Shirasaki, Keita Fukushima, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Mouse colonic organoid acquires wnt-independent survival property after long-term inflammation.. AOCC2016 2016.07.08 Kyoto International Conference Center, Kyoto（JAPAN）

  26. Tomoaki Shirasaki, Kiichiro Tsuchiya, Shuji Hibiya, Ryu Nishimura, Keita Fukushima, Sho Watanabe, Ryuichi Okamoto, Tetsuya Nakamura and Mamoru Watanabe. Stimulation with the ligands of Toll like receptors in primary human organoids.. AOCC2016 2016.07.07 Kyoto International Conference Center, Kyoto（JAPAN）

  27. Tomoaki Shirasaki, Keita Fukushima, Kiichirou Tsuchiya, Shuji Hibiya, Ryohei Hayashi, Nobukatsu Horita, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. TNF-α stabilizes atoh1 protein in colitis-associated colorectal cancer resulting in enhanced malignant potential. . UEGW2015 2015.10.28 Barcelona

  28. Shuji Hibiya, Kiichiro Tsuchiya, Tomoaki Shirasaki, Keita Fukushima, Ryohei Hayashi, Nobukatsu Horita, Shigeru Oshima , Ryuichi Okamoto, Tetsuya Nakamura,Mamoru Watanabe. Contiuous stimulation with cytokines leads to irreversible activation of NF-γb signaling in colonic epithelial cells by organoid culture . UEGW2015 2015.10.27 Barcelona

  29. Kiichiro Tsuchiya, Ryohei Hayashi, Shuji Hibiya, Keita Fukushima, Nobukatsu Horita, Tomoaki Shirasaki, Mamoru Watanabe. Mapping biopsy of entire small intestine revealed specific gene expression in crohn's disease . UEGW2015 2015.10.27 Barcelona

  30. Kiichiro Tsuchiya, Shuji Hibiya, Mamoru Watanabe. Acquisition of enhanced malignant potential in inflammation associated colon cancer. The 74th Annual Meeting of the Japanese Cancer Association 2015.10.09 Nagoya

  31. Shuji Hibiya, Kiichiro Tsuchiya, Keita Fukushima, Ryohei Hayashi, Nobukatsu Horita, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Continuous Stimulation With Cytokines Leads to Irreversible Accumulation of NF-kB Signaling in Colonic Epithelial Cells. DDW 2015 2015.05.19 Washinguton DC

  32. Hibiya S, Tsuchiya K, Fukushima K, Hayashi R, Horita N, Kano Y , Okamoto R, Nakamura T,Watanabe M. Long-term stimulation with cytokines acquires irreversible accumulation of NF-κB signaling in primary colonic epithelial cells. 4th International Symposium on Carcinogenic Spiral 2014.02.11 Sapporo

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