Personnel Information

写真a

NIBE Yoichi


Job title

Assistant Professor
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Campus Career 【 display / non-display 】

  • 2012.04
    -
    2016.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Systemic Organ Regulation， Gastroenterology and Hepatology， Graduate Student
  • 2018.04
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    2021.03
    Tokyo Medical and Dental University， Medical Research Institute， Assistant Professor
  • 2021.04
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    2022.04
    Tokyo Medical and Dental University， Medical Research Institute， Pathophysiology， Pathological Cell Biology， Assistant Professor
  • 2022.05
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    2022.07
    Tokyo Medical and Dental University， Medical Research Institute， Division of Advanced Pathophysiological Science， Department of Pathological Cell Biology， Assistant Professor
  • 2022.08
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    2024.03
    Tokyo Medical and Dental University， Medical Research Institute， Division of Advanced Pathophysiological Science， Department of Pathological Cell Biology， Assistant Professor
  • 2024.04
    -
    Now
    Tokyo Medical and Dental University， TMDU Advanced Research Institute (TMDU-ARIS)， Project Research Division， Pathological Cell Biology Laboratory， Assistant Professor

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Qualification Acquired 【 display / non-display 】

  • Doctor

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Published Papers & Misc 【 display / non-display 】

  1. Tsujioka, M; Miyazawa, K; Ohmuraya, M; Nibe, Y; Shirokawa, T; Hayasaka, H; Mizushima, T; Fukuma, T; Shimizu, S. Identification of a novel type of focal adhesion remodelling via FAK/FRNK replacement, and its contribution to cancer progression CELL DEATH & DISEASE. 2023.04; 14 (4): 256. ( PubMed, DOI )

  2. Tamura A, Ito G, Matsuda H, Nibe-Shirakihara Y, Hiraoka Y, Kitagawa S, Hiraguri Y, Nagata S, Aonuma E, Otsubo K, Nemoto Y, Nagaishi T, Watanabe M, Okamoto R, Oshima S. Zranb1-mutant mice display abnormal colonic mucus production and exacerbation of DSS-induced colitis. Biochemical and biophysical research communications. 2022.11; 628 147-154. ( PubMed, DOI )

  3. Matsuda H, Nibe-Shirakihara Y, Tamura A, Aonuma E, Arakawa S, Otsubo K, Nemoto Y, Nagaishi T, Tsuchiya K, Shimizu S, Ma A, Watanabe M, Uo M, Okamoto R, Oshima S. Nickel particles are present in Crohn's disease tissue and exacerbate intestinal inflammation in IBD susceptible mice. Biochemical and biophysical research communications. 2022.02; 592 74-80. ( PubMed, DOI )

  4. Aonuma, E; Tamura, A; Matsuda, H; Asakawa, T; Sakamaki, Y; Otsubo, K; Nibe, Y; Onizawa, M; Nemoto, Y; Nagaishi, T; Tsuchiya, K; Nakamura, T; Uo, M; Watanabe, M; Okamoto, R; Oshima, S. Nickel ions attenuate autophagy flux and induce transglutaminase 2 (TG2) mediated post-translational modification of SQSTM1/p62 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2021.02; 542 17-23. ( PubMed, DOI )

  5. Otsubo, K; Maeyashiki, C; Nibe, Y; Tamura, A; Aonuma, E; Matsuda, H; Kobayashi, M; Onizawa, M; Nemoto, Y; Nagaishi, T; Okamoto, R; Tsuchiya, K; Nakamura, T; Torii, S; Itakura, E; Watanabe, M; Oshima, S. Receptor-Interacting Protein Kinase 3 (RIPK3) inhibits autophagic flux during necroptosis in intestinal epithelial cells FEBS LETTERS. 2020.05; 594 (10): 1586-1595. ( PubMed, DOI )

  6. Akiyama Shintaro, Mochizuki Wakana, Nibe Yoichi, Matsumoto Yuka, Sakamoto Kei, Oshima Shigeru, Watanabe Mamoru, Nakamura Tetsuya. マウス結腸杯細胞集団にて、CCN3発現は独特なスルホムチン非産生亜細胞集団を標識する(CCN3 Expression Marks a Sulfomucin-nonproducing Unique Subset of Colonic Goblet Cells in Mice) Acta Histochemica et Cytochemica. 2017.12; 50 (6): 159-168. ( ichushi )

  7. Akiyama S, Mochizuki W, Nibe Y, Matsumoto Y, Sakamoto K, Oshima S, Watanabe M, Nakamura T. CCN3 Expression Marks a Sulfomucin-nonproducing Unique Subset of Colonic Goblet Cells in Mice. Acta histochemica et cytochemica. 2017.12; 50 (6): 159-168. ( PubMed, DOI )

  8. Yoichi Nibe, Shigeru Oshima, Masanori Kobayashi, Chiaki Maeyashiki, Yu Matsuzawa, Kana Otsubo, Hiroki Matsuda, Emi Aonuma, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Shinichiro Nakada, Mamoru Watanabe. Novel polyubiquitin imaging system, PolyUb-FC, reveals that K33-linked polyubiquitin is recruited by SQSTM1/p62. Autophagy. 2017.11; 14 (2): 1-43. ( PubMed, DOI )

  9. Chiaki Maeyashiki, Shigeru Oshima, Kana Otsubo, Masanori Kobayashi, Yoichi Nibe, Yu Matsuzawa, Michio Onizawa, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. HADHA, the alpha subunit of the mitochondrial trifunctional protein, is involved in long-chain fatty acid-induced autophagy in intestinal epithelial cells. Biochem. Biophys. Res. Commun.. 2017.03; 484 (3): 636-641. ( PubMed, DOI )

  10. Masanori Kobayashi, Shigeru Oshima, Chiaki Maeyashiki, Yoichi Nibe, Kana Otsubo, Yu Matsuzawa, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. The ubiquitin hybrid gene UBA52 regulates ubiquitination of ribosome and sustains embryonic development. Sci Rep. 2016.11; 6 36780. ( PubMed, DOI )

  11. Taichi Matsumoto, Wakana Mochizuki, Yoichi Nibe, Shintaro Akiyama, Yuka Matsumoto, Kengo Nozaki, Masayoshi Fukuda, Ayumi Hayashi, Tomohiro Mizutani, Shigeru Oshima, Mamoru Watanabe, Tetsuya Nakamura. Retinol Promotes In Vitro Growth of Proximal Colon Organoids through a Retinoic Acid-Independent Mechanism. PLoS ONE. 2016.08; 11 (8): e0162049. ( PubMed, DOI )

  12. Yu Matsuzawa, Shigeru Oshima, Masahiro Takahara, Chiaki Maeyashiki, Yasuhiro Nemoto, Masanori Kobayashi, Yoichi Nibe, Kengo Nozaki, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Averil Ma, Mamoru Watanabe. TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy. Autophagy. 2015.06; 11 (7): 1052-1062. ( PubMed, DOI )

  13. Yu Matsuzawa, Shigeru Oshima, Yoichi Nibe, Masanori Kobayashi, Chiaki Maeyashiki, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. RIPK3 regulates p62-LC3 complex formation via the caspase-8-dependent cleavage of p62. Biochem Biophys Res Commun. 2015.01; 456 (1): 298-304. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Kana Otsubo, Yoichi Nibe, Chiaki Maeyashiki, Akiko Tamura, Emi Aonuma, Hiroki Matsuda, Mamoru Watanabe, Shigeru Oshima. The role of ubiquitination in crosstalk of intestinal epithelial cell death and autophagic signaling was revealed by a novel polyubiquitin imaging system.. 19th International congress of mucosal immunology 2019.07.17 the Brisbane Convention & Exhibition Centre(Brisbane, Australia)

  2. Oshima Shigeru, Nibe Yoichi, Tamura Akiko, Matsuda Hiroki, Aonuma Emi, Otsubo Kana, Watanabe Mamoru. K33-linked polyubiquitin is recruited by SQSTM1/p62. Keystone Symposia: Autophagy(B2) 2019.02.19 Eldorado Hotel &Spa（Santa Fe, New Mexico, USA ）

  3. Matsuda H, Nibe Y, Aonuma E, Otsubo K, Maeyashiki C, Kobayashi M, Matsuzawa Y, Nakada S, Watanabe M, Oshima S. K33-linked polyubiquitin is recruited by SQSTM1/p62.. Keystone Symposia - Ubiquitin Signaling (A8) 2018.01.30 Tahoe(USA)

  4. Nibe Y, Matsuda H, Aonuma E, Otsubo K, Maeyashiki C, Kobayashi M, Matsuzawa Y, Nakada S, Mamoru Watanabe M, Oshima S. Novel polyubiquitin imaging system, PolyUb-FC, visualized atypical polyubiquitin chain in living cells.. Keystone Symposia - Ubiquitin Signaling (A8) 2018.01.30 Tahoe(USA)

  5. Otsubo K, Maeyashiki C, Aonuma E, Matsuda H, Nibe Y, Kobayashi M, Matsuzawa Y, Watanabe M, Oshima S. Long-chain fatty acid regulates autophagy and polyubiquitination in intestinal epithelial cells. Keystone Symposia - Ubiquitin Signaling (A8) 2018.01.30 Tahoe(USA)

  6. Aonuma E, Nibe Y, Matsuda H, Otsubo K, Maeyashiki C, Kobayashi M, Matsuzawa Y, Watanabe M, Oshima S. Necroptosis stimulation regulates SQSTM1/p62-LC3 complex formation and polyubiquitination. Keystone Symposia - Ubiquitin Signaling (A8) 2018.01.29 Tahoe(USA)

  7. Nibe Y, Oshima S, Aonuma E, Matsuda H, Otsubo K, Maeyashiki C, Kobayashia M, Matsuzawa Y , Nakada S, Watanabe M. Novel polyubiquitin imaging reveals that atypical polyubiquitin contribute to autophagy. GI research Academy 2017 2017.06.09 Tokyo (JAPAN)

  8. Yoichi Nibe, Shigeru Oshima, Emi Aonuma, Hiroki Matsuda, Kana Otsubo, Chiaki Maeyashiki, Masanori Kobayashi, Yu Matsuzawa, Shinichiro Nakada, Mamoru Watanabe. Novel polyubiquitin imaging reveals that atypical polyubiquitin contribute to autophagy via p62.. The 8th International Symposium on Autophagy 2017.05.29 Nara Kasugano International Forum 甍 IRAKA(Japan)

  9. Kana Otsubo, Shigeru Oshima, Chiaki Maeyashiki, Emi Aonuma, Hiroki Matsuda, Masanori Kobayashi, Yoichi Nibe, Yu Matsuzawa, Mamoru Watanabe. HADHA, the alpha subunit of the mitochondrial trifunctional protein, is involved in long-chain fatty acid-induced autophagy in intestinal epithelial cells. The 8th International Symposium on Autophagy 2017.05.29 Nara Kasugano International Forum 甍 IRAKA(Japan)

  10. Kobayashi m, Oshima S, Maeyashiki C, Nibe Y, Otsubo K, Watanabe M. The Ubiquitin Hybrid Gene UBA52 Regulates Cell Cycle and Ubiquitination of Ribosome in Colon Cancer. DDW 2017 2017.05.09 Chicago (USA)

  11. Masanori Kobayashi, Shigeru Oshima, Yoishi Nibe, Chiaki Maeyashiki, Mamoru Watanabe. UBA52, ubiquitin hybrid ribisomal protein, regulates NF-κB signaling in colon cancer. DDW2016 2016.05.24 San Diego（USA）

  12. Chiaki Maeyashiki, Shigeru Oshima, Yoishi Nibe, Masanori Kobayashi, Mamoru Watanabe. Indentification of autophagic regulators as therapeutic targets in intestinal epithelial cells. DDW2016 2016.05.23 San Diego（USA）

  13. Masanori Kobayashi, Shigeru Oshima, Yoishi Nibe, Chiaki Maeyashiki, Mamoru Watanabe. UBA52, ubiquitin hybrid protein, regulates NF κB signaling. 第102回日本消化器病学会総会_The 5th International Forum 2016.04.21 京王プラザホテル（東京都新宿区）

  14. 大島　茂、前屋舗千明、仁部洋一、小林正典、松沢　優、鬼澤道夫、Averil Ma、渡辺　守. TNFAIP3 によるネクロプトーシス制御機構の解明. 第24回日本Cell Death学会学術集会 2015.07.11 大阪

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