Graduating School 【 display / non-display 】
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Tokyo Medical and Dental University, Graduated
Campus Career 【 display / non-display 】
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2012.04-2017.03Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Environmental Response, Rheumatology, Graduate Student
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2017.04-2019.10Tokyo Medical and Dental University, (Old Organization)Medical Hospital, Hospital Departments, Department of Internal Medicine, Rheumatology, Assistant Professor
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2017.04-NowTokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Environmental Response, Rheumatology, Assistant Professor
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2018.04-NowTokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Environmental Response, Rheumatology, Assistant Professor
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2019.11-2021.03Tokyo Medical and Dental University, (Old Organization)Medical Hospital, Hospital Departments, Department of Internal Medicine, Rheumatology, Assistant Professor
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2021.04-2023.04Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Environmental Response, Rheumatology, Assistant Professor
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2023.05-NowTokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Environmental Response, Rheumatology, Assistant Professor
Research Areas 【 display / non-display 】
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Connective tissue disease and allergy
Published Papers & Misc 【 display / non-display 】
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Izuka S, Umezawa N, Komai T, Sugimori Y, Kimura N, Mizoguchi F, Fujieda Y, Ninagawa K, Iwasaki T, Suzuki K, Takeuchi T, Ohmura K, Mimori T, Atsumi T, Kawakami E, Suzuki A, Kochi Y, Yamamoto K, Yasuda S, Okamura T, Ota M, Fujio K. The muscle tissue transcriptome of idiopathic inflammatory myopathy reflects the muscle damage process by monocytes and presence of skin lesions. Arthritis & rheumatology (Hoboken, N.J.). 2024.08; ( PubMed, DOI )
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Miyamae T, Manabe Y, Sugihara T, Umezawa N, Yoshifuji H, Tamura N, Abe Y, Furuta S, Nagafuchi H, Ishizaki J, Nakano N, Atsumi T, Karino K, Amano K, Kurasawa T, Ito S, Yoshimi R, Ogawa N, Banno S, Naniwa T, Ito S, Hara A, Hirahara S, Uchida HA, Onishi Y, Murakawa Y, Komagata Y, Nakaoka Y, Harigai M. Pregnancy and childbirth in Takayasu arteritis in Japan: A nationwide retrospective study. Modern rheumatology. 2024.08; ( PubMed, DOI )
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Nishimura K, Ishikawa T, Okamoto N, Akamine K, Inoue N, Irabu H, Kato K, Keino H, Kojima M, Kubo H, Maruyama K, Mizuta M, Shabana K, Shimizu M, Sugita Y, Takakuwa Y, Takanashi S, Takase H, Umebayashi H, Umezawa N, Yamanishi S, Yamazaki K, Yashiro M, Yasumi T, Mori M. Efficacy and safety of abatacept for systemic juvenile idiopathic arthritis: a systematic review. Modern rheumatology. 2024.05; ( PubMed, DOI )
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Ishikawa T, Nishimura K, Okamoto N, Akamine K, Inoue N, Irabu H, Kato K, Keino H, Kojima M, Kubo H, Maruyama K, Mizuta M, Shabana K, Shimizu M, Sugita Y, Takakuwa Y, Takanashi S, Takase H, Umebayashi H, Umezawa N, Yamanishi S, Yamazaki K, Yashiro M, Yasumi T, Mori M. Efficacy and safety of tumor necrosis factor inhibitors for systemic juvenile idiopathic arthritis: a systematic review. Modern rheumatology. 2024.05; ( PubMed, DOI )
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T Tsubata, N Umezawa, T Yasumi, H Kanegane, S Yasuda. Impaired development of B cells with PRF1 variants in an adult Scand J Rheumatol. 2024.01; 53 (1): 74-76. ( PubMed, DOI )
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Sasaki H, Umezawa N, Itakura T, Iwai H, Yasuda S. Pathogenicity of functionally activated PD-1(+)CD8(+) cells and counterattacks by muscular PD-L1 through IFNγ in myositis. Journal of autoimmunity. 2023.11; 142 103131. ( PubMed, DOI )
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Tanaka K, Ichikawa A, Umezawa N, Yamamoto K, Yoshifuji K, Okada K, Nogami A, Umezawa Y, Nagao T, Sakashita C, Mori T, Tohda S, Koike R, Yasuda S, Yamamoto M. Lymphoproliferative disorder risk after methotrexate treatment for rheumatoid arthritis. Cancer science. 2023.06; 114 (9): 3719-3727. ( PubMed, DOI )
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Sugihara T, Yoshifuji H, Uchida HA, Maejima Y, Watanabe Y, Tanemoto K, Umezawa N, Manabe Y, Ishizaki J, Shirai T, Nagafuchi H, Hasegawa H, Niiro H, Ishii T, Nakaoka Y, Harigai M. Establishing clinical remission criteria for giant cell arteritis: Results of a Delphi exercise carried out by an expert panel of the Japan Research Committee of the Ministry of Health, Labour, and Welfare for Intractable Vasculitis. Modern rheumatology. 2023.05; 34 (3): 568-575. ( PubMed, DOI )
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Fujiwara S, Kawamoto A, Motobayashi M, Hibiya S, Takenaka K, Shimizu H, Saito E, Fujii T, Nagahori M, Kawata D, Umezawa N, Hosoya T, Yasuda S, Ohtsuka K, Okamoto R. Hemorrhagic gastric ulcer in a patient with Behcet's disease successfully treated with infliximab. DEN open. 2023.04; 3 (1): e196. ( PubMed, DOI )
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Umezawa N, Mizoguchi F, Maejima Y, Kimura N, Hasegawa H, Hosoya T, Fujimoto M, Kohsaka H, Naka T, Yasuda S. Leucine-rich alpha-2 glycoprotein as a potential biomarker for large vessel vasculitides. Frontiers in medicine. 2023.04; 10 1153883. ( PubMed, DOI )
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Itakura T, Sasaki H, Hosoya T, Yamaguchi T, Mimori E, Saimon Y, Iwai H, Umezawa N, Kawata D, Kimura N, Kurata M, Shimizu M, Yasuda S. A novel gain-of-function missense variant in PLCG2 associated with autoinflammation and hypergammaglobulinemia. Rheumatology (Oxford, England). 2023.04; 62 (11): e319-e321. ( PubMed, DOI )
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Kamiya M, Kimura N, Umezawa N, Hasegawa H, Yasuda S. Muscle fiber necroptosis in pathophysiology of idiopathic inflammatory myopathies and its potential as target of novel treatment strategy. Frontiers in immunology. 2023.04; 14 1191815. ( PubMed, DOI )
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Umezawa N, Sasaki H, Furusawa H, Kawata D, Hata C, Yasuda S. Development of vasculitis in a case with severe asthma treated with benralizumab and low-dose corticosteroid. Allergology international : official journal of the Japanese Society of Allergology. 2022.09; 72 (1): 179-181. ( PubMed, DOI )
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Yoshizuka R, Hasegawa H, Kamiya M, Umezawa N, Yasuda S. Refractory antiphospholipid antibody syndrome-induced thrombocytopaenia successfully treated with belimumab. Lupus. 2022.04; 31 (5): 624-627. ( PubMed, DOI )
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Fumiaki Kondo, Takahiko Sugihara, Natsuka Umezawa, Hisanori Hasegawa, Tadashi Hosoya, Naoki Kimura, Masaaki Mori, Shinsuke Yasuda. Associated factors with poor treatment response to initial glucocorticoid therapy in patients with adult-onset Still's disease. Arthritis Res Ther. 2022.04; 24 (1): 92. ( PubMed, DOI )
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Nishijima H, Sugita M, Umezawa N, Kimura N, Sasaki H, Kawano H, Nishioka Y, Matsumoto M, Oya T, Tsuneyama K, Morimoto J, Matsumoto M. Development of organ-specific autoimmunity by dysregulated Aire expression. Immunology and cell biology. 2022.03; 100 (5): 371-377. ( PubMed, DOI )
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Sugihara T, Nakaoka Y, Uchida HA, Yoshifuji H, Maejima Y, Watanabe Y, Amiya E, Tanemoto K, Miyata T, Umezawa N, Manabe Y, Ishizaki J, Shirai T, Nagafuchi H, Hasegawa H, Miyamae T, Niiro H, Ito S, Ishii T, Isobe M, Harigai M. Establishing Clinical Remission Criteria and the Framework of a Treat-To-Target Algorithm for Takayasu arteritis: Results of a Delphi Exercise Carried out by an Expert Panel of the Japan Research Committee of the Ministry of Health, Labour, and Welfare for intractable vasculitis. Modern rheumatology. 2021.11; 32 (5): 930-937. ( PubMed, DOI )
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Natsuki Aokia , Taro Fujikawaa , Natsuka Umezawab , Yoshiyuki Kawashimaa , Taku Itoa , Keiji Hondaa , and Takeshi Tsutsumia. 3Tesla magnetic resonance imaging reveals vasculitis-caused otitis media in a patient with giant cell arteritis ACTA OTO-LARYNGOLOGICA CASE REPORTS. 2021; 6 6-10. ( DOI )
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Fujikawa T, Honda K, Ito T, Kishino M, Kimura N, Umezawa N, Hirano M, Aoki N, Kawashima Y, Tsutsumi T. Enhanced fallopian canal as a potential marker for temporal bone vasculitis. Laryngoscope investigative otolaryngology. 2020.12; 5 (6): 1168-1175. ( PubMed, DOI )
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Tanaka N, Terao C, Nakayama Y, Sasai T, Umezawa N, Yagyu Y, Ito K, Koike R, Nakashima R, Hatta K, Mizoguchi F. Anti-MDA5 antibody-positive dermatomyositis with rapidly progressive interstitial lung disease disguising as anti-synthetase syndrome. Rheumatology (Oxford, England). 2020.10; 60 (3): e104-e106. ( PubMed, DOI )
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Natsuka Umezawa, Kimito Kawahata, Fumitaka Mizoguchi, Naoki Kimura, Yoko Yoshihashi-Nakazato, Nobuyuki Miyasaka, Hitoshi Kohsaka. Interleukin-23 as a therapeutic target for inflammatory myopathy. Scientific Reports. 2018.04; 8 (1): 5498. ( PubMed, DOI )
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Natsuka Umezawa, Hitoshi Kohsaka, Toshihiro Nanki, Kaori Watanabe, Michi Tanaka, Peter Y Shane, Nobuyuki Miyasaka. Successful treatment of eosinophilic granulomatosis with polyangiitis (EGPA; formerly Churg-Strauss syndrome) with rituximab in a case refractory to glucocorticoids, cyclophosphamide, and IVIG. Modern Rheumatolgy. 2014.07; 24 (4): 685-687. ( PubMed, DOI )
Conference Activities & Talks 【 display / non-display 】
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梅澤 夏佳、木村 直樹、吉橋洋子、上阪 等. 多発性筋炎/皮膚筋炎患者の前脛骨筋を対象としたコンコトーム筋生検の有用性. 第45回日本臨床免疫学会総会 2017.09.29
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Natsuka Umezawa, Kimito Kawahata, Naoki Kimura, Yoko Yoshihashi- Nakazato, Hitoshi Kohsaka. Interleukin-23 as a therapeutic target for inflammatory myopathy. 7th East Asian Group of Rheumatology 2017.07.07