Personnel Information

写真a

SUKEGAWA Sayaka


Job title

Assistant Professor
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Graduating School 【 display / non-display 】

  • Toho University, Faculty of Pharmaceutical Science, 2009.03, Graduated

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Graduate School 【 display / non-display 】

  • Tokyo Medical and Dental University, Molecular virology, Master's Course, 2011.03, Completed

  • Tokyo Medical and Dental University, Molecular virology, Doctor's Course, 2015.03, Completed

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Campus Career 【 display / non-display 】

  • 2019.04
    -
    2020.06
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Environmental Response， Molecular Virology， Assistant Professor
  • 2020.07
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Environmental Response， Molecular Virology， Assistant Professor
  • 2023.04
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Molecular Virology， Junior Associate Professor (Career Track)
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External Career 【 display / non-display 】

  • 2015.04
    -
    2017.02
    National Institutes of Health, National Institute of Allergy and Infectious Diseases, Visiting Fellow
  • 2017.03
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    2018.03
    National Institutes of Health, National Institute of Allergy and Infectious Diseases,
  • 2018.04
    -
    2019.03
    National Hospital Organization Nagoya Medical Center, Clinical research center, Department of Infectious Diseases and Immunology, Project Researcher
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Research Areas 【 display / non-display 】

  • Virology

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Qualification Acquired 【 display / non-display 】

  • Pharmacist

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Research Theme 【 display / non-display 】

  • Investigation of the mechanisms of Human mannose receptor 1 on HIV-1 replication., 2015.04 - 2018.03

  • Investigation of the role of HIV-1 Vpr in replication and searching binding partner(s) with Vpr, 2015.04 - 2017.03

  • Investigation of the mechanisms of rhesus macaque TRIM5a-mediated late restriction of HIV-1 lifecycle., 2009.04 - 2015.03

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Published Papers & Misc 【 display / non-display 】

  1. Fabryova H, Kao S, Sukegawa S, Miyagi E, Taylor L, Ferhadian D, Saito H, Schaal H, Hillebrand F, Strebel K.. HIV-1 Vpr Induces Degradation of Gelsolin, a Myeloid Cell-Specific Host Factor That Reduces Viral Infectivity by Inhibiting the Expression and Packaging of the HIV-1 Env Glycoprotein. mBio. 2023.02; ( DOI )

  2. Kitamura H, Sukegawa S, Matsuda K, Tanimoto K, Kobayakawa T, Takahashi K, Tamamura H, Tsuchiya K, Gatanaga H, Maeda K, Takeuchi H.. 4-phenylquinoline-8-amine induces HIV-1 reactivation and apoptosis in latently HIV-1 infected cells Biochem Biophys Res Commun. 2023.01; ( DOI )

  3. Sayaka Sukegawa and Hiroaki Takeuchi. Toward the unveiling of HIV-1 dynamics: Involvement of monocytes/macrophages in HIV-1 infection Frontiers in Virology. 2022.07; ( DOI )

  4. Shigemi U, Yamamura Y, Matsuda M, Okazaki R, Kubota M, Ibe S, Nemoto M, Maejima-Kitagawa M, Sukegawa S, Imahashi M, Kikuchi T, Sugiura W, Iwatani Y, Hachiya A, Yokomaku Y;. Evaluation of the Geenius HIV 1/2 confirmatory assay for HIV-2 samples isolated in Japan. Journal of clinical virology. 2022.07; ( PubMed, DOI )

  5. Kao S, Miyagi E, Mallorson R, Saito H, Sukegawa S, Mukherji A, Mateja A, Ferhadian D, Fabryova H, Clouse K, Strebel K.. The Myeloid-Specific Transcription Factor PU.1 Upregulates Mannose Receptor Expression but Represses Basal Activity of the HIV-LTR Promoter. Journal of Virology. 2022.07; 96 (14): ( PubMed, DOI )

  6. Eri Miyagi, Sarah Welbourn, Sayaka Sukegawa, Helena Fabryova, Sandra Kao, Klaus Strebel. Inhibition of Vif-Mediated Degradation of APOBEC3G through Competitive Binding of Core-Binding Factor Beta. J Virol. 2020.03; 94 (7): ( PubMed, DOI )

  7. Shiroishi-Wakatsuki T, Maejima-Kitagawa M, Hamano A, Murata D, Sukegawa S, Matsuoka K, Ode H, Hachiya A, Imahashi M, Yokomaku Y, Nomura N, Sugiura W, Iwatani Y.. Discovery of 4-oxoquinolines, a new chemical class of anti-HIV-1 compounds. Antiviral Research. 2019.02;

  8. Suzuki N, Yoshida T, Takeuchi H, Sakuma R, Sukegawa S, Yamaoka S.. Robust Enhancement of Lentivirus Production by Promoter Activation. Scientific Reports. 2018.10;

  9. Siddiqui R, Suzu S, Ueno M, Nasser H, Koba R, Bhuyan F, Noyori O, Hamidi S, Sheng G, Yasuda-Inoue M, Hishiki T, Sukegawa S, Miyagi E, Strebel K, Matsushita S, Shimotohno K, Ariumi Y.. Apolipoprotein E is an HIV-1-inducible inhibitor of viral production and infectivity in macrophages. PLoS Pathogen. 2018.10;

  10. Kawano K, Doucet AJ, Ueno M, Kariya R, An W, Marzetta F, Kuroki M, Turelli P, Sukegawa S, Okada S, Strebel K, Trono D, Ariumi Y.. HIV-1 Vpr and p21 restrict LINE-1 mobility. Nucleic Acids Research. 2018.09;

  11. Sukegawa S, Miyagi E, Bouamr F, Farkašová H, Strebel K.. Mannose Receptor 1 Restricts HIV Particle Release from Infected Macrophages. 2018.01;

  12. Sukegawa S, Sakuma R, Ohmine S, Takeuchi H, Ikeda Y, Yamaoka S.. Suppressor of cytokine signaling 1 counteracts rhesus macaque TRIM5α-induced inhibition of human immunodeficiency virus type-1 production. PLoS One. 2014.10;

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Conference Activities & Talks 【 display / non-display 】

  1. Human mannose receptor 1 attenuates HIV-1 infectivity in a virus isolate-specific manner. 2022.05.23

  2. Miyagi E, Kao S, Mallorson R, Saito H, Sukegawa S, Mukherji A, Ferhadian D, Fabryova H, Clouse K, Strebel K.. The myeloid-specific transcription factor PU.1 upregulates mannose receptor expression but represses basal activity of the HIV-LTR promoter.. Cold Spring Harbor Laboratory Retrovirus meeting 2022.05.23 USA, NY

  3. Farkašová H, Sukegawa S, Miyagi E, Taylor L, Kao S, Ferhadian D, Schaal H, Hillebrand F, Strebel K.. HIV-1 Vpr induces degradation of Gelsolin, a myeloid cell-specific host factor that reduces viral infectivity by inhibiting expression and packaging of the HIV-1 Env glycoprotein.. Cold Spring Harbor Laboratory Retrovirus meeting 2022.05.23 USA, NY

  4. HIV-1 replication and latency is modulated by host Solute Carrier Protein (SCP) expression levels in human cells. Cold Spring Harbor Laboratory Retrovirus meeting 2022.05.23 USA, NY

  5. DNA-repair factor complex contributes to maintenance of HIV-1 latency. 2022.05.23

  6. Sukegawa S, Miyagi E, Bouamr F, Farkašová H, Iwatani Y, Strebel K.. Mannose receptor 1 inhibits virus release from HIV-1-infected human macrophages. . The 30th International workshop on Retroviral Pathogenesis 2018.10

  7. Sukegawa S, Miyagi E, Bouamr F, Farkašová H, Iwatani Y, Strebel K. Mannose receptor 1 inhibits virus release from HIV-1-infected human macrophages.. The 30th International workshop on Retroviral Pathogenesis 2018.10

  8. Sukegawa S, Iwatani Y, Strebel K.. Human mannose receptor 1 attenuates HIV-1 infectivity in a virus isolate-specific manner.. 第66回　日本ウイルス学会学術集会 2018.10

  9. Sukegawa S, Miyagi E, Bouamr F, Strebel K.. Mannose receptor 1 inhibits virus release from HIV-1-infected human macrophages. 第31回　日本エイズ学会学術集会 2017.11

  10. Sukegawa Sukegawa. Mannose receptor1 inhibits virus release from HIV-1 infected human macrophages. 国立感染症研究所・学友会セミナー 2017.11

  11. Sukegawa S, Miyagi E, Bouamr F, Strebel K.. Mannose receptor inhibits virus release from infected human macrophages.. Cold Spring Harbor Laboratory Retrovirus meeting 2017.05

  12. Sukegawa S, Miyagi E, Bouamr F, Strebel K.. Mannose receptor inhibits virus release from infected human macrophages. . HIV-1 (Dynamics and Replication Program) DRP Think Tank Program 2017.04

  13. Sayaka Sukegawa, Ryuta Sakuma, Seiga Ohmine, Yasuhiro Ikeda, Shoji Yamaoka. Suppressor of Cytokine Signaling 1 Counteracts Rhesus Macaque TRIM5-Induced Inhibition of HIV-1 Production. Cold Spring Harbor Laboratory meeting 2014 2014.05

  14. Sayaka Sukegawa, Ryuta Sakuma, Seiga Ohmine, Yasuhiro Ikeda, Shoji Yamaoka. The Role of Suppressor of Cytokine Signaling 1 (SOCS1) in Rhesus Macaque TRIM5a-mediated restriction of HIV-1 production and its cell line dependency. International Union of Microviological societies 2011 congress in Sapporo 2011.09

  15. Ryuta Sakuma,Sayaka Sukegawa, Seiga Ohmine, Yasuhiro Ikeda, Shoji Yamaoka. The Role of Suppressor of cytokine signaling in Rhesus Macaque TRIM5a-mediated late restriction and its cell line dependency . Cold Spring Harbor Laboratory meeting 2011 2011.05

  16. Sayaka Sukegawa, Ryuta Sakuma, Seiga Ohmine, Yasuhiro Ikeda, Shoji Yamaoka. Involvement of suppressor of cytokine signaling 1 (SOCS1) protein in Rhesus Macaque TRIM5-mediated restriction of HIV-1 production. 第11回熊本エイズセミナー・GCOE合同国際シンポジウム 2010.10

  17. Ryuta Sakuma,Sayaka Sukegawa, Seiga Ohmine, Yasuhiro Ikeda, Shoji Yamaoka. Involvement of suppressor of cytokine signaling 1 (SOCS1) protein in the Rhesus Macaque TRIM5a-mediated late restriction. Cold Spring Harbor Laboratory meeting 2010 2010.05

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