Personnel Information

写真a

IHARA Kensuke


Job title

Project Assistant Professor

Graduating School 【 display / non-display

  • Tokyo Medical and Dental University, Faculty of Medicine, 2005.03, Graduated

Graduate School 【 display / non-display

  • Tokyo Medical and Dental University, Doctor's Course, 2014.03, Completed

Campus Career 【 display / non-display

  • 2013.04
    -
    2014.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Cardiovascular Medicine, Senior Resident
  • 2014.04
    -
    2014.10
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Molecular Cellular Cardiology, Technical Assistant
  • 2014.11
    -
    2015.08
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Cognitive and Behavioral Medicine, Neurology and Neurological Science, Project Researcher
  • 2015.09
    -
    2022.04
    Tokyo Medical and Dental University, Medical Research Institute, Advanced Molecular Medicine, Bio-informational Pharmacology, Assistant Professor
  • 2022.05
    -
    2023.03
    Tokyo Medical and Dental University, Medical Research Institute, Division of Biological Data Science, Department of Bio-informational Pharmacology, Assistant Professor
  • 2023.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Cardiovascular Medicine, Project Assistant Professor

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External Career 【 display / non-display

  • 2005.04
    -
    2006.03
    , Trainee Resident
  • 2006.04
    -
    2007.03
    , Trainee Resident
  • 2007.04
    -
    2009.03
    , Senior Resident
  • 2009.04
    -
    2011.03
    , Senior Resident
  • 2011.04
    -
    2013.03
    , Senior Resident

Research Areas 【 display / non-display

  • Cardiology

Qualification Acquired 【 display / non-display

  • Doctor

 

Published Papers & Misc 【 display / non-display

  1. Nakagama S, Maejima Y, Fan Q, Shiheido-Watanabe Y, Tamura N, Ihara K, Sasano T. Endoplasmic Reticulum Selective Autophagy Alleviates Anthracycline-Induced Cardiotoxicity. JACC. CardioOncology. 2023.10; 5 (5): 656-670. ( PubMed, DOI )

  2. Sasano T, Ihara K, Tanaka T, Furukawa T. Risk stratification of atrial fibrillation and stroke using single nucleotide polymorphism and circulating biomarkers. PloS one. 2023.10; 18 (10): e0292118. ( PubMed, DOI )

  3. Nakagama S, Maejima Y, Fan Q, Shiheido-Watanabe Y, Tamura N, Ihara K, Sasano T. . Endoplasmic Reticulum Selective Autophagy Alleviates Anthracycline-Induced Cardiotoxicity. J Am Coll Cardiol CardioOnc.. 2023.07;

  4. Ihara Kensuke, Sasano Tetsuo. Extracellular Vesicles for the Treatment of Atrial Fibrillation JACC-CLINICAL ELECTROPHYSIOLOGY. 2023.02; 9 (2): 159-160. ( PubMed, DOI )

  5. Yamamoto Takuma, Sano Rie, Miura Aya, Imasaka Mai, Naito Yoshiro, Nishiguchi Minori, Ihara Kensuke, Otani Naruhito, Kominato Yoshihiko, Ohmuraya Masaki, Kuroyanagi Hidehito, Nishio Hajime. I536T variant of RBM20 affects splicing of cardiac structural proteins that are causative for developing dilated cardiomyopathy JOURNAL OF MOLECULAR MEDICINE-JMM. 2022.12; 100 (12): 1741-1754. ( PubMed, DOI )

  6. Kaburagi Hidetoshi, Nagata Tetsuya, Enomoto Mitsuhiro, Hirai Takashi, Ohyagi Masaki, Ihara Kensuke, Yoshida-Tanaka Kie, Ebihara Satoe, Asada Ken, Yokoyama Hiroyuki, Okawa Atsushi, Yokota Takanori. Systemic DNA/RNA heteroduplex oligonucleotide administration for regulating the gene expression of dorsal root ganglion and sciatic nerve MOLECULAR THERAPY-NUCLEIC ACIDS. 2022.06; 28 910-919. ( PubMed, DOI )

  7. Kawajiri K, Ihara K, Sasano T. Gene therapy to terminate tachyarrhythmias. Expert review of cardiovascular therapy. 2022.06; 20 (6): 431-442. ( PubMed, DOI )

  8. Hamada Satomi, Sasaki Kanae, Kito Hotaka, Tooyama Yui, Ihara Kensuke, Aoyagi Eiko, Ichimura Naoya, Tohda Shuji, Sasano Tetsuo. Effect of the recording condition on the quality of a single-lead electrocardiogram HEART AND VESSELS. 2022.06; 37 (6): 1010-1026. ( PubMed, DOI )

  9. Ihara Kensuke, Sasano Tetsuo. Role of Inflammation in the Pathogenesis of Atrial Fibrillation FRONTIERS IN PHYSIOLOGY. 2022.04; 13 862164. ( PubMed, DOI )

  10. Ihara Kensuke, Sasano Tetsuo. Seeking a Better Experimental Model of Atrial Fibrillation CIRCULATION JOURNAL. 2022.02; 86 (2): 330-331. ( PubMed, DOI )

  11. Yamaguchi J, Chiba R, Komuro H, Ihara K, Nozaki K, Nagai A, Furukawa T, Sasano T. Local Injection of Hydroxyapatite Electret Ameliorated Infarct Size After Myocardial Infarction. Circulation reports. 2022.01; 4 (1): 38-47. ( PubMed, DOI )

  12. Ohyagi Masaki, Nagata Tetsuya, Ihara Kensuke, Yoshida-Tanaka Kie, Nishi Rieko, Miyata Haruka, Abe Aya, Mabuchi Yo, Akazawa Chihiro, Yokota Takanori. DNA/RNA heteroduplex oligonucleotide technology for regulating lymphocytes in vivo NATURE COMMUNICATIONS. 2021.12; 12 (1): 7344. ( PubMed, DOI )

  13. Nagata Tetsuya, Dwyer Chrissa A., Yoshida-Tanaka Kie, Ihara Kensuke, Ohyagi Masaki, Kaburagi Hidetoshi, Miyata Haruka, Ebihara Satoe, Yoshioka Kotaro, Ishii Takashi, Miyata Kanjiro, Miyata Kenichi, Powers Berit, Igari Tomoko, Yamamoto Syunsuke, Arimura Naoto, Hirabayashi Hideki, Uchihara Toshiki, Hara Rintaro Iwata, Wada Takeshi, Bennett C. Frank, Seth Punit P., Rigo Frank, Yokota Takanori. Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS NATURE BIOTECHNOLOGY. 2021.08; 39 (12): 1529-+. ( PubMed, DOI )

  14. Yamazoe Masahiro, Sasano Tetsuo, Ihara Kensuke, Takahashi Kentaro, Nakamura Wakana, Takahashi Naomi, Komuro Hiroaki, Hamada Satomi, Furukawa Tetsushi. Sparsely methylated mitochondrial cell free DNA released from cardiomyocytes contributes to systemic inflammatory response accompanied by atrial fibrillation SCIENTIFIC REPORTS. 2021.03; 11 (1): 5837. ( PubMed, DOI )

  15. Yang Xiaoxi, Sasano Tetsuo, Ebana Yusuke, Takeuchi Jun K., Ihara Kensuke, Yamazoe Masahiro, Furukawa Tetsushi. Functional Role of the L396R Mutation of Tks5 Identified by an Exome-Wide Association Study in Atrial Fibrillation CIRCULATION JOURNAL. 2020.12; 84 (12): 2148-+. ( PubMed, DOI )

  16. Ihara K, Sasano T, Hiraoka Y, Togo-Ohno M, Soejima Y, Sawabe M, Tsuchiya M, Ogawa H, Furukawa T, Kuroyanagi H. A missense mutation in the RSRSP stretch of Rbm20 causes dilated cardiomyopathy and atrial fibrillation in mice. Scientific reports. 2020.10; 10 (1): 17894. ( PubMed, DOI )

  17. Lee Jiyoung, Sutani Akito, Kaneko Rin, Takeuchi Jun, Sasano Tetsuo, Kohda Takashi, Ihara Kensuke, Takahashi Kentaro, Yamazoe Masahiro, Morio Tomohiro, Furukawa Tetsushi, Ishino Fumitoshi. In vitro generation of functional murine heart organoids via FGF4 and extracellular matrix NATURE COMMUNICATIONS. 2020.09; 11 (1): 4283. ( PubMed, DOI )

  18. Yu Natsume, Kasumi Oaku, Kentaro Takahashi, Wakana Nakamura, Ai Oono, Satomi Hamada, Masahiro Yamazoe, Kensuke Ihara, Takeshi Sasaki, Masahiko Goya, Kenzo Hirao, Tetsushi Furukawa, Tetsuo Sasano. Combined Analysis of Human and Experimental Murine Samples Identified Novel Circulating MicroRNAs as Biomarkers for Atrial Fibrillation. Circ. J.. 2018.03; 82 (4): 965-973. ( PubMed, DOI )

  19. Kensuke Ihara, Koji Sugiyama, Kentaro Takahashi, Masahiro Yamazoe, Tetsuo Sasano, Tetsushi Furukawa. Electrophysiological Assessment of Murine Atria with High-Resolution Optical Mapping Journal of Visualized Experiments. 2018.02;

  20. Kaoru Okishige, Hideshi Aoyagi, Kensuke Ihara, Shinsuke Iwai, Tomofumi Nakamura, Mitsumi Yamashita, Nobutaka Katoh, Tomoaki Hasegawa, Naohiko Kawaguchi, Takehiko Keida, Tetsuo Sasano, Kenzo Hirao. Reappraisal of the clinical implications of adenosine triphosphate in terms of the prediction of reconnection sites in cases with electrical isolation of the pulmonary veins. J Interv Card Electrophysiol. 2015.11; 44 (2): 171-178. ( PubMed, DOI )

  21. Shingo Maeda, Yoshihide Takahashi, Akihiko Nogami, Yasuteru Yamauchi, Yuki Osaka, Yasuhiro Shirai, Kensuke Ihara, Yasuhiro Yokoyama, Makoto Suzuki, Kaoru Okishige, Mitsuhiro Nishizaki, Kenzo Hirao. Seasonal, weekly, and circadian distribution of ventricular fibrillation in patients with J-wave syndrome from the J-PREVENT registry. J Arrhythm. 2015.10; 31 (5): 268-273. ( PubMed, DOI )

  22. Kensuke Ihara, Takeshi Sasaki, Yasuhiro Shirai, Susumu Tao, Shingo Maeda, Mihoko Kawabata, Tetsuo Sasano, Yasuhiro Yokoyama, Mitsuaki Isobe, Kenzo Hirao. High Atrial Defibrillation Threshold With Internal Cardioversion Indicates Arrhythmogenicity of Superior Vena Cava in Non-Long-Standing Persistent Atrial Fibrillation. Circ. J.. 2015.06; 79 (7): 1479-1485. ( PubMed, DOI )

  23. Mihoko Kawabata, Yasuhiro Yokoyama, Takeshi Sasaki, Susumu Tao, Kensuke Ihara, Yasuhiro Shirai, Tetsuo Sasano, Masahiko Goya, Tetsushi Furukawa, Mitsuaki Isobe, Kenzo Hirao. Severe iatrogenic bradycardia related to the combined use of beta-blocking agents and sodium channel blockers. Clin Pharmacol. 2015.02; 7 29-36. ( PubMed, DOI )

  24. Shingo Maeda, Takeshi Sasaki, Yasuhiro Shirai, Kensuke Ihara, Mihoko Kawabata, Yasuhiro Yokoyama, Saman Nazarian, Stefan L Zimmerman, Kenzo Hirao. Association of intramural fat deposition in the interatrial septum with focal atrial tachyarrhythmias originating near the atrioventricular node. Heart Vessels. 2015.01; 30 (1): 143-145. ( PubMed, DOI )

  25. The importance of the setting of the pacing cycle length in the para-Hisian pacing. J Interv Card Electrophysiol.. 2014.10; 39 S56-57.

  26. Kensuke Ihara, Junichi Nitta, Kenzo Hirao, Mitsuaki Isobe. Atrial tachycardia originating from the hepatic segment of inferior vena cava in interruption of inferior vena cava with azygos continuation. J Interv Card Electrophysiol. 2013.04; 36 (3): 261-266. ( PubMed, DOI )

  27. Manabu Kurabayashi, Kaoru Okishige, Mitsutoshi Asano, Hidetoshi Suzuki, Tsukasa Shimura, Shinsuke Iwai, Nobutaka Kato, Kensuke Ihara, Hideshi Aoyagi, Mitsuaki Isobe. Cardiopulmonary arrest caused by coronary spasm after coronary vasodilator withdrawal during the peri-operative period of gastrectomy. Intern. Med.. 2013.01; 52 (1): 81-84. ( PubMed )

  28. Kensuke Ihara, Junichi Nitta, Akira Sato, Shinsuke Iwai, Mitsutoshi Asano, Miki Kanoh, Kenichi Muramatsu, Tsunehiro Yamato, Yutaka Matsumura, Kazuyasu Takei, Kihiro Asakawa, Kenzo Hirao, Mitsuaki Isobe. Coexistence of left-sided atrioventricular accessory pathways with a common inferior pulmonary vein ostium. Circ Arrhythm Electrophysiol. 2011.06; 4 (3): 310-317. ( PubMed, DOI )

  29. Shingo Maeda, Mitsuhiro Nishizaki, Noriyoshi Yamawake, Takashi Ashikaga, Kensuke Ihara, Tadashi Murai, Hiroyuki Fujii, Harumizu Sakurada, Masayasu Hiraoka, Mitsuaki Isobe. Effect of High-dose Telmisartan on the Prevention of Recurrent Atrial Fibrillation in Hypertensive Patients. J Atr Fibrillation. 2010.10; 3 (3): 289. ( PubMed, DOI )

  30. Shingo Maeda, Mitsuhiro Nishizaki, Noriyoshi Yamawake, Takashi Ashikaga, Hiroshi Shimada, Mitsutoshi Asano, Kensuke Ihara, Tadashi Murai, Hidetoshi Suzuki, Hiroyuki Fujii, Harumizu Sakurada, Masayasu Hiraoka, Mitsuaki Isobe. Ambulatory ECG-based T-wave alternans and heart rate turbulence predict high risk of arrhythmic events in patients with old myocardial infarction. Circ. J.. 2009.12; 73 (12): 2223-2228. ( PubMed )

  31. Kensuke Ihara, Mitsuhiro Nishizaki, Harumizu Sakurada, Masayasu Hiraoka. Type 1 ST-segment elevation in the right precordial leads associated with acetylcholine-induced localized spasm of the conus branch of the right coronary artery. Heart Rhythm. 2009.11; 6 (11): 1681-1682. ( PubMed, DOI )

  32. Takashi Ashikaga, Mitsuhiro Nishizaki, Hiroyuki Fujii, Kensuke Ihara, Saori Niki, Tadashi Murai, Shingo Maeda, Noriyoshi Yamawake, Yukio Kishi, Mitsuaki Isobe. Coronary endothelial dysfunction and impaired microcirculation response to atrial natriuretic peptide in hyperinsulinemia. J. Cardiovasc. Pharmacol. Ther.. 2008.03; 13 (1): 58-63. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  1. Shiomi M, Nagata Y, Sudo T, Ichikawa T, Ihara K, Asada K, Tanaka Y, Yamauchi Y, Sasaki T, Hachiya H, Imai Y, Fujita H, Sasano T, Furukawa T, Tanaka T. . Genome-wide association analysis and construction of polygenic risk score model for predicting paroxysmal atrial fibrillation using LightGBM model.. The 7th JCS Council Forum on Basic CardioVascular Research. 2023.12.09

  2. 岩宮賢、井原健介、古川哲史、笹野哲郎.. 心不全モデルマウスにおけるサクビトリル・バルサルタンの心房への抗不整脈効果.. 心電学関連春季大会2023. 2023.04.22

  3. Ishikawa S, Suzuki A, Iwasaki R, Ihara K, Furukawa T, Sasano T. . Epicardial Adipose Tissue Remodeling Evoked by Extracellular Vesicles Released from Atrial Myocytes. . The 68th Annual Meeting of the Japanese Heart Rhythm Society. 2022.06.09 Yokohama.

  4. Sun Y, Kawajiri K, Iwamiya S, Abe K, Ihara K, Sasano T, Furukawa T. . Involvement of Potential microRNAs in Signaling Pathway Networks in Murine Angiotensin II-Mediated Atrial Fibrillation Model. . The 68th Annual Meeting of the Japanese Heart Rhythm Society. 2022.06.09

  5. Kawajiri K, Nyo ZLM, Ihara K, Furukawa T, Sasano T. . The Exosomal miRNA Secreted by Paced Cardiomyocytes Regulates Adipocyte Differentiation. . The 68th Annual Meeting of the Japanese Heart Rhythm Society. 2022.06.09 Yokohama.

  6. Kawabata S, Toide N, Nagata T, Yoshida-tanaka K, Ihara K, Yokota T.. Tricosanoic acid conjugated DNA/RNA heteroduplex oligonucleotide is highly efficient in mouse muscle. . 63rd Annual Meeting of the Japanese Society of Neurology. 2022.05.19

  7. Hasegawa J, Nagata T, Ihara K, Tanihata J, Yokota T.. Development of Lipid-conjugated heteroduplex oligonucleotide as a new treatment for exon skipping. . 63rd Annual Meeting of the Japanese Society of Neurology. 2022.05.18

  8. Iwamiya S, Ihara K, Furukawa T, Sasano T.. The effects of Sacubitril/Valsartan on murine atria with pressure overload.. The 86th Annual Scientific Meeting of the Japanese Circulation Society. 2022.03.13 Online(神戸).

  9. Ihara K, Kuroyanagi H, Hiraoka Y, Sasano T, Furukawa T.. Atrial Fibrillation in Cardiomyopathy Mice with Rbm20 Mutation.. The 86th Annual Scientific Meeting of the Japanese Circulation Society. 2022.03.11 Online(神戸)

  10. Iwamiya S, Ihara K, Furukawa T, Sasano T.. The effects of Sacubitril/Valsartan on electrophysiological properties of atria in murine hearts with pressure overload. . The 5th JCS Council Forum on Basic CardioVascular Research. 2021.09.11 Online(大阪)

  11. 永田哲也, 吉田規恵, 井原健介, 大谷木正貴, 海老原利枝, 吉岡耕太郎, 石井俊, 原倫太朗, 横田隆徳.. 全身投与による中枢神経で有効性を発揮する核酸医薬品の開発.. パーキンソン病・運動障害疾患コングレス. 2021.07.02

  12. Iwamiya S, Ihara K, Tomii N, Yamazaki M, Kuroyanagi H, Sakuma I, Furukawa T, Sasano T. . Electrophysiological Properties of Atrial Arrhythmia in Heart Failure of Mice Detected with Optical Mapping System. . The 85th Annual Scientific Meeting of the Japanese Circulation Society. 2021.03.27 Online(横浜)

  13. Lee J, Sutani A, Kaneko R, Sasano T, Ihara K, Takeuchi J, Furukawa T, Ishino F.. In Vitro Generation of Heart Organoids with Functional Capacity. . The 85th Annual Scientific Meeting of the Japanese Circulation Society. 2021.03.27 Online(横浜)

  14. Ihara K, Kuroyanagi H, Hiraoka Y, Sasano T, Furukawa T.. A mutation in the RSRSP stretch of Rbm20 causes atrial fibrillation in mice. . The 4th JCS Council Forum on Basic CardioVascular Research. 2020.09.26 Online (Nagoya)

  15. Ohyagi M, Nagata T, Ihara K, Nishi R, Mabuchi Y, Akazawa C, Yokota T. . New therapeutic strategy for multiple sclerosis by DNA/RNA heteroduplex oligonucleotide technology.. 61st Annual Meeting of the Japanese Society of Neurology. 2020.09.02

  16. Sasano T, Yamazoe M, Ihara K, Mieda R, Kobayashi K, Hamamoto R, Furukawa T. . Novel Risk Stratification for Atrial Fibrillation Focusing on Atrial Remodeling. . The 84th Annual Scientific Meeting of the Japanese Circulation Society. 2020.07.27

  17. Ihara K, Kuroyanagi H, Hiraoka Y, Sasano T, Furukawa T. . Cytoplasmic Expansion of RNA-Binding Motif Protein 20 (RBM20) is Critical for Development of Atrial Fibrillation in Mice. . The 84th Annual Scientific Meeting of the Japanese Circulation Society. 2020.07.27 Online (Kyoto)

  18. Ihara K, Sasano T, Kentaro T, Yamazoe M, Furukawa T.. Pannexin-1 Contributes to Maintenance of Cardiac Function against Acute Pressure-overload and Rapid Ventricular Pacing. . The 97th Annual Meeting of the Physiological Society of Japan. 2020.03.17 Oita

  19. Yamazoe M, Sasano T, Ihara K, Furukawa T. . Novel single nucleotide polymorphism identified in exome-wide association study contributes to atrial fibrillation via modulation of autonomic nervous function. . The 3rd JCS Council Forum on Basic CardioVascular Research. 2019.09.06 Tokyo

  20. Ohyagi M, Nagata T, Ihara K, Yoshida-Tanaka K, Miyata H, Abe A, Yokota T. . New DNA/RNA heteroduplex oligonucleotide technology for regulating functions of lymphocytes in vivo. . 60th Annual Meeting of the Japanese Society of Neurology. 2019.05.22

  21. Furukawa T, Ihara K, Abe K, Yamazoe M, Takeuchi J, Sasano T. . Role of Gap-Junctional Channel, Pannexin, in I/R Pre-conditioning and Arrhythmias.. The 83rd Annual Scientific Meeting of the Japanese Circulation Society. 2019.03.29

  22. Ihara K, Sasano T, Yamazoe M, Furukawa T.. Intolerance to Rapid Ventricular Pacing and Coronary Hypoplasty in Pannexin-1 Knockout Mouse Heart.. The 83rd Annual Scientific Meeting of the Japanese Circulation Society. 2019.03.29 Yokohama

  23. Yamazoe M, Sasano T, Nakamura W, Ihara K, Takahashi N, Hirao K, Furukawa T. . Rare Methylated Cell-free DNA Released from Cardiomyocytes Contributes to Systemic Inflammatory Response Accompanied with Atrial Fibrillation. . The 83rd Annual Scientific Meeting of the Japanese Circulation Society. 2019.03.29 Yokohama

  24. Chiba R, Yamazoe M, Ihara K, Komuro H, Nagai A, Furukawa T, Sasano T. . Local Injection of Charged Hydroxyapatite Nanoparticle Attenuates the Myocardial Injury in Murine Myocardial Infarction Model.. The 83rd Annual Scientific Meeting of the Japanese Circulation Society. 2019.03.29

  25. Akaza M, Takahashi K, Ihara K, Yamazoe M, Sumi Y, Furukawa T, Sasano T. . Pannexin-1 Maintains Cardiac Function in Pressure Overload Mouse Model.. The 11th Asia-pacific Heart Rhythm Society Scientific Session. 2018.10.17 Taipei, Taiwan.

  26. Ihara K, Sasano T, Yamazoe M, Furukawa T. . Intolerance to Rapid Ventricular Pacing in Pannexin-1 Knockout Mouse Heart.. The 11th Asia-pacific Heart Rhythm Society Scientific Session. 2018.10.17 Taipei, Taiwan.

  27. Yamazoe M, Sasano T, Nakamura W, Ihara K, Takahashi N, Hirao K, Furukawa T.. Cell-free DNA Released from Cardiomyocytes in Atrial Fibrillation induces Systemic ProInflammatory Cytokine Expression.. The 11th Asia-pacific Heart Rhythm Society Scientific Session. 2018.10.17 Taipei, Taiwan.

  28. Sasano T, Yamazoe M, Ihara K, Takahashi K, Natsume Y, Nakamura W, Hirao K, Tanaka M, Furukawa T.. Approach to Improve Risk Stratification for Atrial Fibrillation by Combination of Genetic Risk and Acquired Risk. . The 2nd JCS Council Forum on Basic CardioVascular Research. 2018.09.22 Nara

  29. Ihara K, Sasano T, Yamazoe M, Furukawa T. . Pacemaker activity generated by CRISPR/Cas9 based genome editing for Kcnj2. . The 2nd JCS Council Forum on Basic CardioVascular Research. 2018.09.22 Nara

  30. Sasano T, Yamazoe M, Ihara K, Hirao K, Furukawa T.. Extracellular nucleotides: Novel players for the pathogenesis of atrial fibrillation. . The 2nd JCS Council Forum on Basic CardioVascular Research. 2018.09.22 Nara

  31. Yamazoe M, Sasano T, Nakamura W, Ihara K, Takahashi N, Hirao K, Furukawa T. . Cell-free DNA Released in Atrial Fibrillation Promotes Systemic ProInflammatory Cytokine Expression.. The 2nd JCS Council Forum on Basic CardioVascular Research. 2018.09.22 Nara

  32. Sasano T, Yamazoe M, Ihara K, Takahashi K, Natsume Y, Nakamura W, Hirao K, Tanaka M, Furukawa T.. Approach to Improve Risk Stratification for Atrial Fibrillation by Combination of Genetic Risk and Acquired Risk.. The 65th Annual Meeting of the Japanese Heart Rhythm Society. 2018.07.11 Tokyo

  33. Ihara K, Sasano T, Yamazoe M, Furukawa T. . Intolerance to Rapid Ventricular Pacing and Coronary Insufficiency in Pannexin-1 Knockout Mouse Heart. . The 65th Annual Meeting of the Japanese Heart Rhythm Society. 2018.07.11 Tokyo

  34. Yamazoe M, Sasano T, Nakamura W, Ihara K, Hirao K, Furukawa T. . Cell-free DNA Induces Systemic Pro-inflammatory Response in Atrial Fibrillation.. The 65th Annual Meeting of the Japanese Heart Rhythm Society. 2018.07.11 Tokyo

  35. Yamazoe M, Sasano T, Nakamura W, Takahashi K, Ihara K, Hirao K, Furukawa T. . Cell-Free DNA in Patients with Atrial Fibrillation Promotes Pro-Inflammatory Cytokine Expression in Macrophages.. The 82nd Annual Scientific Meeting of the Japanese Circulation Society. 2018.03.23 大阪.

  36. Ihara K, Sasano T, Takahashi K, Yamazoe M, Furukawa T. . Pannexin-1 Maintains Cardiac Function under the Electrical Pacing and/or Hypoxia in Mice. . The 82nd Annual Scientific Meeting of the Japanese Circulation Society. 2018.03.23 大阪.

  37. Yamazoe M, Sasano T, Nakamura W, Takahashi K, Ihara K, Hirao K, Furukawa T. . Cell Free DNA Released from Cardiomyocytes Induces Pro-Inflammatory Response in Atrial Fibrillation.. The 1st JCS Council Forum on Basic CardioVascular Research. 2018.01.06 東京.

  38. Ihara K, Sasano T, Takahashi K, Yamazoe M, Furukawa T.. Cardioprotective effect of Pannexin-1 against Pacing-induced Cardiac Dysfunction in Mice. . The 1st JCS Council Forum on Basic CardioVascular Research. 2018.01.06 東京.

  39. Nagata T, Ohyagi M, Ihara K, Kaburagi H, Nishina K, Piao W, Yoshida-Tanaka K, Guo H, Kuwahara H, Yoshioka K, Yokota T. . The effect of DNA/RNA heteroduplex oligonucleotides on muscle. . XXIII World Congress of Neurology. 2017.09.16 Kyoto. Japan.

  40. Yamazoe M, Sasano T, Nakamura W, Takahashi K, Ihara K, Furukawa T. . Cell-Free DNA Released from Atrial Cardiomyocytes Promotes Pro-Inflammatory Cytokine IL-6 Expression in Macrophages. . The 10th Asia-pacific Heart Rhythm Society Scientific Session. 2017.09.14 Yokohama. Japan.

  41. Ihara K, Sasano T, Takahashi K, Furukawa T. . Pacemaker activity generated by in vivo genome editing.. The 10th Asia-pacific Heart Rhythm Society Scientific Session. 2017.09.14 Yokohama. Japan.

  42. Sasano T, Takahashi K, Zhang P, Ihara K, Sugiyama K, Tamura N, Nishimura T, Shirai Y, Tao S, Sasaki T, Kawabata M, Goya M, Hirao K, Isobe M, Furukawa T.. Comprehensive analysis linking microRNA and atrial inflammation in mouse and human.. The 79th Annual Scientific Meeting of the Japanese Circulation Society. 2017.03.23 大阪.

  43. Ihara K, Sasano T, Sugiyama K, Takahashi K, Furukawa T. . Generating biological pacemaker by CRISPR/Cas9 based in vivo genome editing.. The 81st Annual Scientific Meeting of the Japanese Circulation Society. 2017.03.23 金沢.

  44. Takahashi K, Sasano T, Ihara K, Isobe M, Furukawa T. . Pannexin-1 Contributes to the Maintenance of Cardiac Function against Acute Pressure-overload as a ‘Mechanosensor’. . The 81st Annual Scientific Meeting of the Japanese Circulation Society. 2017.03.23 金沢.

  45. Nagata T, Ihara K, Kaburagi H, Nishina K, Piao W, Yoshida-Tanaka K, Guo H, Kuwahara H, Yoshioka K, Yokota T.. The effect of DNA/RNA heteroduplex oligonucleotides in multiple organ systems.. 11th Annual Meeting of the Oligonucleotide Therapeutics Society. 2015.10.11 Leiden. Netherlands.

  46. Sasaki T, Goya M, Sasano T, Kawabata M, Tao S, Sugiyama K, Ihara K, Shirai Y, Nishimura T, Sasaoka T, Hatano Y, Tezuka D, Yoshikawa S, Kosuge H, Maejima Y, Koyama N, Terashima M, Ashikaga T, Isobe M, Hirao K.. Prevalence of structural abnormalities detected by cardiac magnetic resonance imaging associated with premature ventricular contraction origins. . The 79th Annual Scientific Meeting of the Japanese Circulation Society. 2015.04.15

  47. Sasano T, Takahashi K, Ihara K, Sugiyama K, Nishimura T, Shirai Y, Tao S, Sasaki T, Kawabata M, Goya M, Hirao K, Isobe M, Furukawa T.. Comprehensive Analysis Identifies common MicroRNA expression Involved in murine models of atrial remodeling and clinical specimen.. The 8th Asia-pacific Heart Rhythm Society Scientific Session. 2015.04.15 Melbourne. Australia.

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