Personnel Information

写真a

IHARA Kensuke


Job title

Assistant Professor

Graduating School 【 display / non-display

  • Tokyo Medical and Dental University, Faculty of Medicine, 2005.03, Graduated

Graduate School 【 display / non-display

  • Tokyo Medical and Dental University, Doctor's Course, 2014.03, Completed

Campus Career 【 display / non-display

  • 2013.04
    -
    2014.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Cardiovascular Medicine, Senior Resident
  • 2014.04
    -
    2014.10
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Molecular Cellular Cardiology, Technical Assistant
  • 2014.11
    -
    2015.08
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Cognitive and Behavioral Medicine, Neurology and Neurological Science, Project Researcher
  • 2015.09
    -
    2022.04
    Tokyo Medical and Dental University, Medical Research Institute, Advanced Molecular Medicine, Bio-informational Pharmacology, Assistant Professor
  • 2022.05
    -
    Now
    Tokyo Medical and Dental University, Medical Research Institute, a, Department of Bio-informational Pharmacology, Assistant Professor

External Career 【 display / non-display

  • 2005.04
    -
    2006.03
    , Trainee Resident
  • 2006.04
    -
    2007.03
    , Trainee Resident
  • 2007.04
    -
    2009.03
    , Senior Resident
  • 2009.04
    -
    2011.03
    , Senior Resident
  • 2011.04
    -
    2013.03
    , Senior Resident

Research Areas 【 display / non-display

  • Cardiology

Qualification Acquired 【 display / non-display

  • Doctor

 

Published Papers & Misc 【 display / non-display

  1. Nagata Tetsuya, Dwyer Chrissa A., Yoshida-Tanaka Kie, Ihara Kensuke, Ohyagi Masaki, Kaburagi Hidetoshi, Miyata Haruka, Ebihara Satoe, Yoshioka Kotaro, Ishii Takashi, Miyata Kanjiro, Miyata Kenichi, Powers Berit, Igari Tomoko, Yamamoto Syunsuke, Arimura Naoto, Hirabayashi Hideki, Uchihara Toshiki, Hara Rintaro Iwata, Wada Takeshi, Bennett C. Frank, Seth Punit P., Rigo Frank, Yokota Takanori. Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS NATURE BIOTECHNOLOGY. 2021.08; ( PubMed, DOI )

  2. Yamazoe Masahiro, Sasano Tetsuo, Ihara Kensuke, Takahashi Kentaro, Nakamura Wakana, Takahashi Naomi, Komuro Hiroaki, Hamada Satomi, Furukawa Tetsushi. Sparsely methylated mitochondrial cell free DNA released from cardiomyocytes contributes to systemic inflammatory response accompanied by atrial fibrillation SCIENTIFIC REPORTS. 2021.03; 11 (1): 5837. ( PubMed, DOI )

  3. Yang Xiaoxi, Sasano Tetsuo, Ebana Yusuke, Takeuchi Jun K., Ihara Kensuke, Yamazoe Masahiro, Furukawa Tetsushi. Functional Role of the L396R Mutation of Tks5 Identified by an Exome-Wide Association Study in Atrial Fibrillation CIRCULATION JOURNAL. 2020.12; 84 (12): 2148-+. ( PubMed, DOI )

  4. Ihara K, Sasano T, Hiraoka Y, Togo-Ohno M, Soejima Y, Sawabe M, Tsuchiya M, Ogawa H, Furukawa T, Kuroyanagi H. A missense mutation in the RSRSP stretch of Rbm20 causes dilated cardiomyopathy and atrial fibrillation in mice. Scientific reports. 2020.10; 10 (1): 17894. ( PubMed, DOI )

  5. Lee Jiyoung, Sutani Akito, Kaneko Rin, Takeuchi Jun, Sasano Tetsuo, Kohda Takashi, Ihara Kensuke, Takahashi Kentaro, Yamazoe Masahiro, Morio Tomohiro, Furukawa Tetsushi, Ishino Fumitoshi. In vitro generation of functional murine heart organoids via FGF4 and extracellular matrix NATURE COMMUNICATIONS. 2020.09; 11 (1): 4283. ( PubMed, DOI )

  6. Yu Natsume, Kasumi Oaku, Kentaro Takahashi, Wakana Nakamura, Ai Oono, Satomi Hamada, Masahiro Yamazoe, Kensuke Ihara, Takeshi Sasaki, Masahiko Goya, Kenzo Hirao, Tetsushi Furukawa, Tetsuo Sasano. Combined Analysis of Human and Experimental Murine Samples Identified Novel Circulating MicroRNAs as Biomarkers for Atrial Fibrillation. Circ. J.. 2018.03; 82 (4): 965-973. ( PubMed, DOI )

  7. Kensuke Ihara, Koji Sugiyama, Kentaro Takahashi, Masahiro Yamazoe, Tetsuo Sasano, Tetsushi Furukawa. Electrophysiological Assessment of Murine Atria with High-Resolution Optical Mapping Journal of Visualized Experiments. 2018.02;

  8. 井原健介. 抗不整脈薬 臨床検査. 2016.10; 60 (11): 1285-1287.

  9. Kaoru Okishige, Hideshi Aoyagi, Kensuke Ihara, Shinsuke Iwai, Tomofumi Nakamura, Mitsumi Yamashita, Nobutaka Katoh, Tomoaki Hasegawa, Naohiko Kawaguchi, Takehiko Keida, Tetsuo Sasano, Kenzo Hirao. Reappraisal of the clinical implications of adenosine triphosphate in terms of the prediction of reconnection sites in cases with electrical isolation of the pulmonary veins. J Interv Card Electrophysiol. 2015.11; 44 (2): 171-178. ( PubMed, DOI )

  10. Shingo Maeda, Yoshihide Takahashi, Akihiko Nogami, Yasuteru Yamauchi, Yuki Osaka, Yasuhiro Shirai, Kensuke Ihara, Yasuhiro Yokoyama, Makoto Suzuki, Kaoru Okishige, Mitsuhiro Nishizaki, Kenzo Hirao. Seasonal, weekly, and circadian distribution of ventricular fibrillation in patients with J-wave syndrome from the J-PREVENT registry. J Arrhythm. 2015.10; 31 (5): 268-273. ( PubMed, DOI )

  11. Kensuke Ihara, Takeshi Sasaki, Yasuhiro Shirai, Susumu Tao, Shingo Maeda, Mihoko Kawabata, Tetsuo Sasano, Yasuhiro Yokoyama, Mitsuaki Isobe, Kenzo Hirao. High Atrial Defibrillation Threshold With Internal Cardioversion Indicates Arrhythmogenicity of Superior Vena Cava in Non-Long-Standing Persistent Atrial Fibrillation. Circ. J.. 2015.06; 79 (7): 1479-1485. ( PubMed, DOI )

  12. Mihoko Kawabata, Yasuhiro Yokoyama, Takeshi Sasaki, Susumu Tao, Kensuke Ihara, Yasuhiro Shirai, Tetsuo Sasano, Masahiko Goya, Tetsushi Furukawa, Mitsuaki Isobe, Kenzo Hirao. Severe iatrogenic bradycardia related to the combined use of beta-blocking agents and sodium channel blockers. Clin Pharmacol. 2015.02; 7 29-36. ( PubMed, DOI )

  13. Shingo Maeda, Takeshi Sasaki, Yasuhiro Shirai, Kensuke Ihara, Mihoko Kawabata, Yasuhiro Yokoyama, Saman Nazarian, Stefan L Zimmerman, Kenzo Hirao. Association of intramural fat deposition in the interatrial septum with focal atrial tachyarrhythmias originating near the atrioventricular node. Heart Vessels. 2015.01; 30 (1): 143-145. ( PubMed, DOI )

  14. The importance of the setting of the pacing cycle length in the para-Hisian pacing. J Interv Card Electrophysiol.. 2014.10; 39 S56-57.

  15. Kensuke Ihara, Junichi Nitta, Kenzo Hirao, Mitsuaki Isobe. Atrial tachycardia originating from the hepatic segment of inferior vena cava in interruption of inferior vena cava with azygos continuation. J Interv Card Electrophysiol. 2013.04; 36 (3): 261-266. ( PubMed, DOI )

  16. Manabu Kurabayashi, Kaoru Okishige, Mitsutoshi Asano, Hidetoshi Suzuki, Tsukasa Shimura, Shinsuke Iwai, Nobutaka Kato, Kensuke Ihara, Hideshi Aoyagi, Mitsuaki Isobe. Cardiopulmonary arrest caused by coronary spasm after coronary vasodilator withdrawal during the peri-operative period of gastrectomy. Intern. Med.. 2013.01; 52 (1): 81-84. ( PubMed )

  17. Kensuke Ihara, Junichi Nitta, Akira Sato, Shinsuke Iwai, Mitsutoshi Asano, Miki Kanoh, Kenichi Muramatsu, Tsunehiro Yamato, Yutaka Matsumura, Kazuyasu Takei, Kihiro Asakawa, Kenzo Hirao, Mitsuaki Isobe. Coexistence of left-sided atrioventricular accessory pathways with a common inferior pulmonary vein ostium. Circ Arrhythm Electrophysiol. 2011.06; 4 (3): 310-317. ( PubMed, DOI )

  18. Shingo Maeda, Mitsuhiro Nishizaki, Noriyoshi Yamawake, Takashi Ashikaga, Kensuke Ihara, Tadashi Murai, Hiroyuki Fujii, Harumizu Sakurada, Masayasu Hiraoka, Mitsuaki Isobe. Effect of High-dose Telmisartan on the Prevention of Recurrent Atrial Fibrillation in Hypertensive Patients. J Atr Fibrillation. 2010.10; 3 (3): 289. ( PubMed, DOI )

  19. Shingo Maeda, Mitsuhiro Nishizaki, Noriyoshi Yamawake, Takashi Ashikaga, Hiroshi Shimada, Mitsutoshi Asano, Kensuke Ihara, Tadashi Murai, Hidetoshi Suzuki, Hiroyuki Fujii, Harumizu Sakurada, Masayasu Hiraoka, Mitsuaki Isobe. Ambulatory ECG-based T-wave alternans and heart rate turbulence predict high risk of arrhythmic events in patients with old myocardial infarction. Circ. J.. 2009.12; 73 (12): 2223-2228. ( PubMed )

  20. Kensuke Ihara, Mitsuhiro Nishizaki, Harumizu Sakurada, Masayasu Hiraoka. Type 1 ST-segment elevation in the right precordial leads associated with acetylcholine-induced localized spasm of the conus branch of the right coronary artery. Heart Rhythm. 2009.11; 6 (11): 1681-1682. ( PubMed, DOI )

  21. Takashi Ashikaga, Mitsuhiro Nishizaki, Hiroyuki Fujii, Kensuke Ihara, Saori Niki, Tadashi Murai, Shingo Maeda, Noriyoshi Yamawake, Yukio Kishi, Mitsuaki Isobe. Coronary endothelial dysfunction and impaired microcirculation response to atrial natriuretic peptide in hyperinsulinemia. J. Cardiovasc. Pharmacol. Ther.. 2008.03; 13 (1): 58-63. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  1. Iwamiya S, Ihara K, Furukawa T, Sasano T.. The effects of Sacubitril/Valsartan on electrophysiological properties of atria in murine hearts with pressure overload. . The 5th JCS Council Forum on Basic CardioVascular Research. 2021.09.11 Online(大阪)

  2. Iwamiya S, Ihara K, Tomii N, Yamazaki M, Kuroyanagi H, Sakuma I, Furukawa T, Sasano T. . Electrophysiological Properties of Atrial Arrhythmia in Heart Failure of Mice Detected with Optical Mapping System. . The 85th Annual Scientific Meeting of the Japanese Circulation Society. 2021.03.27 Online(横浜)

  3. Lee J, Sutani A, Kaneko R, Sasano T, Ihara K, Takeuchi J, Furukawa T, Ishino F.. In Vitro Generation of Heart Organoids with Functional Capacity. . The 85th Annual Scientific Meeting of the Japanese Circulation Society. 2021.03.27 Online(横浜)

  4. Ihara K, Kuroyanagi H, Hiraoka Y, Sasano T, Furukawa T.. A mutation in the RSRSP stretch of Rbm20 causes atrial fibrillation in mice. . The 4th JCS Council Forum on Basic CardioVascular Research. 2020.09.26 Online (Nagoya)

  5. Sasano T, Yamazoe M, Ihara K, Mieda R, Kobayashi K, Hamamoto R, Furukawa T. . Novel Risk Stratification for Atrial Fibrillation Focusing on Atrial Remodeling. . The 84th Annual Scientific Meeting of the Japanese Circulation Society. 2020.07.27

  6. Ihara K, Kuroyanagi H, Hiraoka Y, Sasano T, Furukawa T. . Cytoplasmic Expansion of RNA-Binding Motif Protein 20 (RBM20) is Critical for Development of Atrial Fibrillation in Mice. . The 84th Annual Scientific Meeting of the Japanese Circulation Society. 2020.07.27 Online (Kyoto)

  7. Ihara K, Sasano T, Kentaro T, Yamazoe M, Furukawa T.. Pannexin-1 Contributes to Maintenance of Cardiac Function against Acute Pressure-overload and Rapid Ventricular Pacing. . The 97th Annual Meeting of the Physiological Society of Japan. 2020.03.17 Oita

  8. Yamazoe M, Sasano T, Ihara K, Furukawa T. . Novel single nucleotide polymorphism identified in exome-wide association study contributes to atrial fibrillation via modulation of autonomic nervous function. . The 3rd JCS Council Forum on Basic CardioVascular Research. 2019.09.06 Tokyo

  9. 笹野哲郎, 山添正博, 棗祐有, 中村和奏, 井原健介, 濱田里美, 古川哲史. 臨床からのアプローチ:心細動における細胞外核酸のバイオマーカーとしての可能性. 第66回日本不整脈心電学会学術大会. 2019.07.24

  10. Furukawa T, Ihara K, Abe K, Yamazoe M, Takeuchi J, Sasano T. . Role of Gap-Junctional Channel, Pannexin, in I/R Pre-conditioning and Arrhythmias.. The 83rd Annual Scientific Meeting of the Japanese Circulation Society. 2019.03.29

  11. Ihara K, Sasano T, Yamazoe M, Furukawa T.. Intolerance to Rapid Ventricular Pacing and Coronary Hypoplasty in Pannexin-1 Knockout Mouse Heart.. The 83rd Annual Scientific Meeting of the Japanese Circulation Society. 2019.03.29 Yokohama

  12. Yamazoe M, Sasano T, Nakamura W, Ihara K, Takahashi N, Hirao K, Furukawa T. . Rare Methylated Cell-free DNA Released from Cardiomyocytes Contributes to Systemic Inflammatory Response Accompanied with Atrial Fibrillation. . The 83rd Annual Scientific Meeting of the Japanese Circulation Society. 2019.03.29 Yokohama

  13. Chiba R, Yamazoe M, Ihara K, Komuro H, Nagai A, Furukawa T, Sasano T. . Local Injection of Charged Hydroxyapatite Nanoparticle Attenuates the Myocardial Injury in Murine Myocardial Infarction Model.. The 83rd Annual Scientific Meeting of the Japanese Circulation Society. 2019.03.29

  14. Akaza M, Takahashi K, Ihara K, Yamazoe M, Sumi Y, Furukawa T, Sasano T. . Pannexin-1 Maintains Cardiac Function in Pressure Overload Mouse Model.. The 11th Asia-pacific Heart Rhythm Society Scientific Session. 2018.10.17 Taipei, Taiwan.

  15. Ihara K, Sasano T, Yamazoe M, Furukawa T. . Intolerance to Rapid Ventricular Pacing in Pannexin-1 Knockout Mouse Heart.. The 11th Asia-pacific Heart Rhythm Society Scientific Session. 2018.10.17 Taipei, Taiwan.

  16. Yamazoe M, Sasano T, Nakamura W, Ihara K, Takahashi N, Hirao K, Furukawa T.. Cell-free DNA Released from Cardiomyocytes in Atrial Fibrillation induces Systemic ProInflammatory Cytokine Expression.. The 11th Asia-pacific Heart Rhythm Society Scientific Session. 2018.10.17 Taipei, Taiwan.

  17. Sasano T, Yamazoe M, Ihara K, Takahashi K, Natsume Y, Nakamura W, Hirao K, Tanaka M, Furukawa T.. Approach to Improve Risk Stratification for Atrial Fibrillation by Combination of Genetic Risk and Acquired Risk. . The 2nd JCS Council Forum on Basic CardioVascular Research. 2018.09.22 Nara

  18. Ihara K, Sasano T, Yamazoe M, Furukawa T. . Pacemaker activity generated by CRISPR/Cas9 based genome editing for Kcnj2. . The 2nd JCS Council Forum on Basic CardioVascular Research. 2018.09.22 Nara

  19. Sasano T, Yamazoe M, Ihara K, Hirao K, Furukawa T.. Extracellular nucleotides: Novel players for the pathogenesis of atrial fibrillation. . The 2nd JCS Council Forum on Basic CardioVascular Research. 2018.09.22 Nara

  20. Yamazoe M, Sasano T, Nakamura W, Ihara K, Takahashi N, Hirao K, Furukawa T. . Cell-free DNA Released in Atrial Fibrillation Promotes Systemic ProInflammatory Cytokine Expression.. The 2nd JCS Council Forum on Basic CardioVascular Research. 2018.09.22 Nara

  21. Sasano T, Yamazoe M, Ihara K, Takahashi K, Natsume Y, Nakamura W, Hirao K, Tanaka M, Furukawa T.. Approach to Improve Risk Stratification for Atrial Fibrillation by Combination of Genetic Risk and Acquired Risk.. The 65th Annual Meeting of the Japanese Heart Rhythm Society. 2018.07.11 Tokyo

  22. Ihara K, Sasano T, Yamazoe M, Furukawa T. . Intolerance to Rapid Ventricular Pacing and Coronary Insufficiency in Pannexin-1 Knockout Mouse Heart. . The 65th Annual Meeting of the Japanese Heart Rhythm Society. 2018.07.11 Tokyo

  23. Yamazoe M, Sasano T, Nakamura W, Ihara K, Hirao K, Furukawa T. . Cell-free DNA Induces Systemic Pro-inflammatory Response in Atrial Fibrillation.. The 65th Annual Meeting of the Japanese Heart Rhythm Society. 2018.07.11 Tokyo

  24. Yamazoe M, Sasano T, Nakamura W, Takahashi K, Ihara K, Hirao K, Furukawa T. . Cell-Free DNA in Patients with Atrial Fibrillation Promotes Pro-Inflammatory Cytokine Expression in Macrophages.. The 82nd Annual Scientific Meeting of the Japanese Circulation Society. 2018.03.23 大阪.

  25. Ihara K, Sasano T, Takahashi K, Yamazoe M, Furukawa T. . Pannexin-1 Maintains Cardiac Function under the Electrical Pacing and/or Hypoxia in Mice. . The 82nd Annual Scientific Meeting of the Japanese Circulation Society. 2018.03.23 大阪.

  26. Yamazoe M, Sasano T, Nakamura W, Takahashi K, Ihara K, Hirao K, Furukawa T. . Cell Free DNA Released from Cardiomyocytes Induces Pro-Inflammatory Response in Atrial Fibrillation.. The 1st JCS Council Forum on Basic CardioVascular Research. 2018.01.06 東京.

  27. Ihara K, Sasano T, Takahashi K, Yamazoe M, Furukawa T.. Cardioprotective effect of Pannexin-1 against Pacing-induced Cardiac Dysfunction in Mice. . The 1st JCS Council Forum on Basic CardioVascular Research. 2018.01.06 東京.

  28. Nagata T, Ohyagi M, Ihara K, Kaburagi H, Nishina K, Piao W, Yoshida-Tanaka K, Guo H, Kuwahara H, Yoshioka K, Yokota T. . The effect of DNA/RNA heteroduplex oligonucleotides on muscle. . XXIII World Congress of Neurology. 2017.09.16 Kyoto. Japan.

  29. Yamazoe M, Sasano T, Nakamura W, Takahashi K, Ihara K, Furukawa T. . Cell-Free DNA Released from Atrial Cardiomyocytes Promotes Pro-Inflammatory Cytokine IL-6 Expression in Macrophages. . The 10th Asia-pacific Heart Rhythm Society Scientific Session. 2017.09.14 Yokohama. Japan.

  30. Ihara K, Sasano T, Takahashi K, Furukawa T. . Pacemaker activity generated by in vivo genome editing.. The 10th Asia-pacific Heart Rhythm Society Scientific Session. 2017.09.14 Yokohama. Japan.

  31. Sasano T, Takahashi K, Zhang P, Ihara K, Sugiyama K, Tamura N, Nishimura T, Shirai Y, Tao S, Sasaki T, Kawabata M, Goya M, Hirao K, Isobe M, Furukawa T.. Comprehensive analysis linking microRNA and atrial inflammation in mouse and human.. The 79th Annual Scientific Meeting of the Japanese Circulation Society. 2017.03.23 大阪.

  32. Ihara K, Sasano T, Sugiyama K, Takahashi K, Furukawa T. . Generating biological pacemaker by CRISPR/Cas9 based in vivo genome editing.. The 81st Annual Scientific Meeting of the Japanese Circulation Society. 2017.03.23 金沢.

  33. Takahashi K, Sasano T, Ihara K, Isobe M, Furukawa T. . Pannexin-1 Contributes to the Maintenance of Cardiac Function against Acute Pressure-overload as a ‘Mechanosensor’. . The 81st Annual Scientific Meeting of the Japanese Circulation Society. 2017.03.23 金沢.

  34. 井原健介.. ゲノム編集技術を用いた生物学的ペースメーカ作成. . 第12回平成の会. 2016.11.28 東京.

  35. Nagata T, Ihara K, Kaburagi H, Nishina K, Piao W, Yoshida-Tanaka K, Guo H, Kuwahara H, Yoshioka K, Yokota T.. The effect of DNA/RNA heteroduplex oligonucleotides in multiple organ systems.. 11th Annual Meeting of the Oligonucleotide Therapeutics Society. 2015.10.11 Leiden. Netherlands.

  36. Sasaki T, Goya M, Sasano T, Kawabata M, Tao S, Sugiyama K, Ihara K, Shirai Y, Nishimura T, Sasaoka T, Hatano Y, Tezuka D, Yoshikawa S, Kosuge H, Maejima Y, Koyama N, Terashima M, Ashikaga T, Isobe M, Hirao K.. Prevalence of structural abnormalities detected by cardiac magnetic resonance imaging associated with premature ventricular contraction origins. . The 79th Annual Scientific Meeting of the Japanese Circulation Society. 2015.04.15

  37. Sasano T, Takahashi K, Ihara K, Sugiyama K, Nishimura T, Shirai Y, Tao S, Sasaki T, Kawabata M, Goya M, Hirao K, Isobe M, Furukawa T.. Comprehensive Analysis Identifies common MicroRNA expression Involved in murine models of atrial remodeling and clinical specimen.. The 8th Asia-pacific Heart Rhythm Society Scientific Session. 2015.04.15 Melbourne. Australia.

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