Personnel Information

写真a

TAKASAWA Kei


Job title

Assistant Professor

Mail Address

ktakasawa.ped@tmd.ac.jp

Graduating School 【 display / non-display

  • Tokyo Medical and Dental University, Faculty of Medicine, 2003.03, Graduated

Graduate School 【 display / non-display

  • Tokyo Medical and Dental University, Doctor's Course, 2014.03, Completed

Campus Career 【 display / non-display

  • 2015.04
    -
    2016.05
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Environmental Response, Pediatrics and Developmental Biology, Visiting Lecturer
  • 2016.06
    -
    2017.03
    Tokyo Medical and Dental University, (Old Organization)Medical Hospital, Hospital Departments, Department of Pediatrics, Maternal and Woman's Medicine, Pediatrics, Visiting Lecturer
  • 2017.04
    -
    2018.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Environmental Response, Pediatrics and Developmental Biology, Assistant Professor
  • 2018.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Environmental Response, Pediatrics and Developmental Biology, Assistant Professor
  • 2018.07
    -
    2019.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Endowed Departments, Department of Child Health and Development, Assistant Professor
 

Published Papers & Misc 【 display / non-display

  1. Suzuki Y, Iemura R, Sutani A, Mizuno Y, Adachi E, Ushiama M, Yoshida T, Hirata M, Hoshino A, Yamomoto K, Akashi T, Nakano Y, Isoda T, Takasawa K, Kato M, Takagi M, Okamoto K, Morio T, Kashimada K. Familial and early recurrent pheochromocytoma in a child with a novel in-frame duplication variant of VHL. Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology. 2024.10; 33 (4): 229-237. ( PubMed, DOI )

  2. Kaneko, S; Shimbo, A; Irabu, H; Hatano, M; Takasawa, K; Kamiya, T; Akamine, K; Tanaka, T; Minato, T; Ono, M; Yokoyama, K; Arisaka, A; Yasumi, T; Ueno, K; Fujita, S; Tanaka, Y; Hayashi, D; Nishikawa, H; Fujita, Y; Yuza, Y; Mori, M; Morio, T; Shimizu, M. Pathogenic role and diagnostic utility of interferon-α in histiocytic necrotizing lymphadenitis CLINICAL IMMUNOLOGY. 2024.09; 266 ( PubMed, DOI )

  3. Takasawa Kei, Iemura Ryosei, Orimoto Ryuta, Yamano Haruki, Kirino Shizuka, Adachi Eriko, Saito Yoko, Yamamoto Kurara, Matsuda Nozomi, Takishima Shigeru, Shuno Kumi, Tajima Hanako, Sugie Manabu, Mizuno Yuki, Sutani Akito, Okamoto Kentaro, Masue Michiya, Morio Tomohiro, Kashimada Kenichi. Clinical management of diazoxide-unresponsive congenital hyperinsulinism: A single-center experience(タイトル和訳中) Clinical Pediatric Endocrinology. 2024.07; 33 (3): 187-194. ( ichushi )

  4. Adachi E, Nakagawa R, Tsuji-Hosokawa A, Gau M, Kirino S, Yogi A, Nakatani H, Takasawa K, Yamaguchi T, Kosho T, Murakami M, Tajima T, Hasegawa T, Yamada T, Morio T, Ohara O, Kashimada K. A MinION-based Long-Read Sequencing Application With One-Step PCR for the Genetic Diagnosis of 21-Hydroxylase Deficiency. The Journal of clinical endocrinology and metabolism. 2024.02; 109 (3): 750-760. ( PubMed, DOI )

  5. Takasawa K, Iemura R, Orimoto R, Yamano H, Kirino S, Adachi E, Saito Y, Yamamoto K, Matsuda N, Takishima S, Shuno K, Tajima H, Sugie M, Mizuno Y, Sutani A, Okamoto K, Masue M, Morio T, Kashimada K. Clinical management of diazoxide-unresponsive congenital hyperinsulinism: A single-center experience. Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology. 2024; 33 (3): 187-194. ( PubMed, DOI )

  6. Arisa Nakamura, Eriko Adachi, Yohei Matsubara, Taku Ishii, Susumu Hosokawa, Kenichi Kashimada, Kei Takasawa. Monitoring hypoparathyroidism in long QT syndrome detected by ECG screening. Pediatr Int. 2023.01; e15481. ( PubMed, DOI )

  7. Wakatsuki Ryosuke, Shimizu Masaki, Shimbo Asami, Adachi Eriko, Kanamori Toru, Yamazaki Susumu, Udagawa Tomohiro, Takasawa Kei, Kashimada Kenichi, Morio Tomohiro, Mori Masaaki. 全身性エリテマトーデスを伴った萎縮性自己免疫性甲状腺炎(Atrophic autoimmune thyroiditis complicated with systemic lupus erythematosus) Modern Rheumatology Case Reports. 2023.01; 7 (1): 65-67. ( ichushi )

  8. Takizawa Chieko, Nakatani Hisae, Saito Yoko, Tsuji-Hosokawa Atsumi, Kikuchi Eriko, Shimoda Masuhiro, Takasawa Kei. 高カルシウム血症エピソードが出現した常染色体顕性低カルシウム血症の1例(A hypercalcemic episode in an adolescent with autosomal dominant hypocalcemia) Pediatrics International. 2023; 65 (1): 1 of 3-3 of 3. ( ichushi )

  9. Nakamura Arisa, Adachi Eriko, Matsubara Yohei, Ishii Taku, Hosokawa Susumu, Kashimada Kenichi, Takasawa Kei. 心電図スクリーニングで発見されたQT延長症候群例での副甲状腺機能低下症のモニタリング(Monitoring hypoparathyroidism in long QT syndrome detected by electrocardiogram screening) Pediatrics International. 2023; 65 (1): 1 of 3-3 of 3. ( ichushi )

  10. Kazuhiro Watanabe, Atsumi Tsuji-Hosokawa, Atsuko Hashimoto, Kaoru Konishi, Nobuyuki Ishige, Harumi Yajima, Akito Sutani, Hisae Nakatani, Maki Gau, Kei Takasawa, Toshihiro Tajima, Tomonobu Hasegawa, Tomohiro Morio, Kenichi Kashimada. The High Relevance of 21-Deoxycortisol, (Androstenedione + 17α-Hydroxyprogesterone)/Cortisol, and 11-Deoxycortisol/17α-Hydroxyprogesterone for Newborn Screening of 21-Hydroxylase Deficiency. J Clin Endocrinol Metab. 2022.11; 107 (12): 3341-3352. ( PubMed, DOI )

  11. Kirino, S; Suzuki, M; Ogawa, T; Takasawa, K; Adachi, E; Gau, M; Takahashi, K; Ikeno, M; Yamada, M; Suzuki, H; Kosaki, K; Moriyama, K; Yoshida, M; Morio, T; Kashimada, K. Clinical report: Chronic liver dysfunction in an individual with an AMOTL1 variant EUROPEAN JOURNAL OF MEDICAL GENETICS. 2022.11; 65 (11): ( PubMed, DOI )

  12. Iemura Ryosei, Kirino Shizuka, Sutani Akito, Kashimada Kenichi, Takasawa Kei. TSHR体細胞変異に起因する自律機能性甲状腺結節(Autonomously functioning thyroid nodule due to a somatic TSHR mutation) Pediatrics International. 2022.08; 64 (1): 1 of 3-3 of 3. ( ichushi )

  13. Ishii Tomohiro, Kashimada Kenichi, Amano Naoko, Takasawa Kei, Nakamura-Utsunomiya Akari, Yatsuga Shuichi, Mukai Tokuo, Ida Shinobu, Isobe Mitsuhisa, Fukushi Masaru, Satoh Hiroyuki, Yoshino Kaoru, Otsuki Michio, Katabami Takuyuki, Tajima Toshihiro, Differences of Sex Development(DSD) and Adrenal Disorders Committee, Japanese Society for Pediatric Endocrinology, Committee on Mass Screening, Japanese Society for Pediatric Endocrinology, Japanese Society for Neonatal Screening, Japanese Society for Pediatric Urology, Japan Endocrine Society. 21-水酸化酵素欠損症の診断・治療のガイドライン(2021年改訂版)(Clinical guidelines for the diagnosis and treatment of 21-hydroxylase deficiency(2021 revision)) Clinical Pediatric Endocrinology. 2022.07; 31 (3): 116-143. ( ichushi )

  14. Kei Takasawa, Kenichi Kashimada. Toward Improving the Transition of Patients With Congenital Adrenal Hyperplasia From Pediatrics to Adult Healthcare in Japan. Front Pediatr. 2022.06; 10 936944. ( PubMed, DOI )

  15. Yamaguchi Yohei, Takasawa Kei, Irabu Hitoshi, Hiratoko Kanako, Ichigi Yosuke, Hirata Ko, Tamura Yumie, Murakoshi Miki, Yamashita Motoi, Nakatani Hisae, Shimoda Masuhiro, Ishii Taku, Udagawa Tomohiro, Shimizu Masaki, Kanegane Hirokazu, Morio Tomohiro. 日本人小児の難治性COVID-19関連多系統炎症性症候群に対するインフリキシマブ治療(Infliximab treatment for refractory COVID-19-associated multisystem inflammatory syndrome in a Japanese child) Journal of Infection and Chemotherapy. 2022.06; 28 (6): 814-818. ( ichushi )

  16. Yamaguchi Y, Takasawa K, Irabu H, Hiratoko K, Ichigi Y, Hirata K, Tamura Y, Murakoshi M, Yamashita M, Nakatani H, Shimoda M, Ishii T, Udagawa T, Shimizu M, Kanegane H, Morio T. Infliximab treatment for refractory COVID-19-associated multisystem inflammatory syndrome in a Japanese child. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2022.01; ( PubMed, DOI )

  17. Takasawa Kei, Nakamura-Utsunomiya Akari, Amano Naoko, Ishii Tomohiro, Hasegawa Tomonobu, Hasegawa Yukihiro, Tajima Toshihiro, Ida Shinobu. 日本における21-水酸化酵素欠損症に対する移行期医療の現状 小児内分泌医の展望(Current status of transition medicine for 21-hydroxylase deficiency in Japan: from the perspective of pediatric endocrinologists) Endocrine Journal. 2022.01; 69 (1): 75-83. ( ichushi )

  18. Saito Yoko, Takasawa Kei, Gau Maki, Yamauchi Takeru, Nakagawa Ryuichi, Miyakawa Yuichi, Sutani Akito, Hosokawa-Tsuji Atsumi, Takishima Shigeru, Matsubara Yohei, Morio Tomohiro, Kashimada Kenichi. 21水酸化酵素欠損症患者における2歳時点の副腎抑制と体格データはヒドロコルチゾンの初期投与量に影響されない(Adrenal suppression and anthropometric data at two years of age was not influenced by the initial hydrocortisone dose in patients with 21-hydroxylase deficiency) Clinical Pediatric Endocrinology. 2021.10; 30 (4): 155-161. ( ichushi )

  19. Asada, K; Komatsu, M; Shimoyama, R; Takasawa, K; Shinkai, N; Sakai, A; Bolatkan, A; Yamada, M; Takahashi, S; Machino, H; Kobayashi, K; Kaneko, S; Hamamoto, R. Application of Artificial Intelligence in COVID-19 Diagnosis and Therapeutics JOURNAL OF PERSONALIZED MEDICINE. 2021.09; 11 (9): ( PubMed, DOI )

  20. Kaneko, S; Takasawa, K; Asada, K; Shinkai, N; Bolatkan, A; Yamada, M; Takahashi, S; Machino, H; Kobayashi, K; Komatsu, M; Hamamoto, R. Epigenetic Mechanisms Underlying COVID-19 Pathogenesis BIOMEDICINES. 2021.09; 9 (9): ( PubMed, DOI )

  21. Hisae Nakatani, Kei Takasawa, Kenichi Kashimada, Akira Morimoto, Akihiro Oshiba, Masayuki Nagasawa. Central diabetes insipidus developing in a 6-year-old patient 4 years after the remission of unifocal bone Langerhans cell histiocytosis. Clin Pediatr Endocrinol. 2021.07; 30 (3): 149-153. ( PubMed, DOI )

  22. Nakatani Hisae, Takasawa Kei, Kashimada Kenichi, Morimoto Akira, Oshiba Akihiro, Nagasawa Masayuki. 単骨型ランゲルハンス細胞組織球症の寛解から4年後に発症した6歳の中枢性尿崩症(Central diabetes insipidus developing in a 6-year-old patient 4 years after the remission of unifocal bone Langerhans cell histiocytosis) Clinical Pediatric Endocrinology. 2021.07; 30 (3): 149-153. ( ichushi )

  23. Kei Takasawa, Yuichi Miyakawa, Yoko Saito, Eriko Adachi, Tsunanori Shidei, Akito Sutani, Maki Gau, Ryuichi Nakagawa, Atsuko Taki, Kenichi Kashimada, Tomohiro Morio. Marked clinical heterogeneity in congenital hyperinsulinism due to a novel homozygous ABCC8 mutation. Clin Endocrinol (Oxf). 2021.06; 94 (6): 940-948. ( PubMed, DOI )

  24. Gau Maki, Konishi Kaoru, Takasawa Kei, Nakagawa Ryuichi, Tsuji-Hosokawa Atsumi, Hashimoto Atsuko, Sutani Akito, Tajima Toshihiro, Hasegawa Tomonobu, Morio Tomohiro, Kashimada Kenichi. The progression of salt-wasting and the body weight change during the first 2 weeks of life in classical 21-hydroxylase deficiency patients. CLINICAL ENDOCRINOLOGY. 2021.02; 94 (2): 229-236. ( PubMed, DOI )

  25. Nozomi Matsuda, Kei Takasawa, Yasuhisa Ohata, Shigeru Takishima, Takuo Kubota, Yasuki Ishihara, Makoto Fujiwara, Erika Ogawa, Tomohiro Morio, Kenichi Kashimada, Keiichi Ozono. Potential pathological role of single nucleotide polymorphism (c.787T>C) in alkaline phosphatase (ALPL) for the phenotypes of hypophosphatasia. Endocr. J.. 2020.12; 67 (12): 1227-1232. ( PubMed, DOI )

  26. Matsuda Nozomi, Takasawa Kei, Ohata Yasuhisa, Takishima Shigeru, Kubota Takuo, Ishihara Yasuki, Fujiwara Makoto, Ogawa Erika, Morio Tomohiro, Kashimada Kenichi, Ozono Keiichi. 低ホスファターゼ症の表現型に対するアルカリホスファターゼ(ALPL)一塩基多型(c.787T>C)の潜在的な病理学的役割(Potential pathological role of single nucleotide polymorphism(c.787T>C) in alkaline phosphatase(ALPL) for the phenotypes of hypophosphatasia) Endocrine Journal. 2020.12; 67 (12): 1227-1232. ( ichushi )

  27. Takeru Yamauchi, Masatoshi Imamura, Kei Takasawa, Keisuke Nakajima, Ryuichi Nakagawa, Maki Gau, Manabu Sugie, Atsuko Taki, Masahiko Kawai, Kenichi Kashimada, Tomohiro Morio. Prematurity at less than 24 weeks of gestation is a risk for prolonged hyperglycemia in extremely low-birth weight infants. Endocrine. 2020.10; 70 (1): 71-77. ( PubMed, DOI )

  28. Yatsuga Shuichi, Amano Naoko, Nakamura-Utsunomiya Akari, Kobayashi Hironori, Takasawa Kei, Nagasaki Keisuke, Nakamura Akie, Nishigaki Satsuki, Numakura Chikahiko, Fujiwara Ikuma, Minamitani Kanshi, Hasegawa Tomonobu, Tajima Toshihiro. Clinical characteristics of cytochrome P450 oxidoreductase deficiency: a nationwide survey in Japan. ENDOCRINE JOURNAL. 2020.08; 67 (8): 853-857. ( DOI )

  29. Yatsuga Shuichi, Amano Naoko, Nakamura-Utsunomiya Akari, Kobayashi Hironori, Takasawa Kei, Nagasaki Keisuke, Nakamura Akie, Nishigaki Satsuki, Numakura Chikahiko, Fujiwara Ikuma, Minamitani Kanshi, Hasegawa Tomonobu, Tajima Toshihiro. チトクロームP450酸化還元酵素欠損症の臨床的特徴 日本で行った全国調査(Clinical characteristics of cytochrome P450 oxidoreductase deficiency: a nationwide survey in Japan) Endocrine Journal. 2020.08; 67 (8): 853-857. ( ichushi )

  30. Shigeru Takishima, Tomotaka Kono, Kei Takasawa, Kenichi Kashimada, Hiroshi Mochizuki. Nocturnal enuresis is a possible symptom of pediatric paraganglioma: A case report. Clin Pediatr Endocrinol. 2020.04; 29 (2): 85-87. ( PubMed, DOI )

  31. Takishima Shigeru, Kono Tomotaka, Takasawa Kei, Kashimada Kenichi, Mochizuki Hiroshi. 夜間遺尿は小児傍神経節腫の一症状の可能性がある 1例報告(Nocturnal enuresis is a possible symptom of pediatric paraganglioma: A case report) Clinical Pediatric Endocrinology. 2020.04; 29 (2): 85-87. ( ichushi )

  32. Takeru Yamauchi, Kei Takasawa, Takahiro Kamiya, Shizuka Kirino, Maki Gau, Kento Inoue, Akihiro Hoshino, Kenichi Kashimada, Hirokazu Kanegane, Tomohiro Morio. Hematopoietic stem cell transplantation recovers insulin deficiency in type 1 diabetes mellitus associated with IPEX syndrome. Pediatr Diabetes. 2019.11; 20 (7): 1035-1040. ( PubMed, DOI )

  33. Hosokawa Yuki, Higuchi Shinji, Kawakita Rie, Hata Ikue, Urakami Tatsuhiko, Isojima Tsuyoshi, Takasawa Kei, Matsubara Yohei, Mizuno Haruo, Maruo Yoshihiro, Matsui Katsuyuki, Aizu Katsuya, Jinno Kazuhiko, Araki Shunsuke, Fujisawa Yasuko, Osugi Koji, Tono Chikako, Takeshima Yasuhiro, Yorifuji Tohru. Pregnancy outcome of Japanese patients with glucokinase-maturity-onset diabetes of the young. JOURNAL OF DIABETES INVESTIGATION. 2019.11; 10 (6): 1586-1589. ( DOI )

  34. Hosokawa Yuki, Higuchi Shinji, Kawakita Rie, Hata Ikue, Urakami Tatsuhiko, Isojima Tsuyoshi, Takasawa Kei, Matsubara Yohei, Mizuno Haruo, Maruo Yoshihiro, Matsui Katsuyuki, Aizu Katsuya, Jinno Kazuhiko, Araki Shunsuke, Fujisawa Yasuko, Osugi Koji, Tono Chikako, Takeshima Yasuhiro, Yorifuji Tohru. 日本人のグルコキナーゼ若年発症成人型糖尿病患者の妊娠アウトカム(Pregnancy outcome of Japanese patients with glucokinase-maturity-onset diabetes of the young) Journal of Diabetes Investigation. 2019.11; 10 (6): 1586-1589. ( ichushi )

  35. Sutani A, Miyakawa Y, Tsuji-Hosokawa A, Nomura R, Nakagawa R, Nakajima K, Maru M, Aoki Y, Takasawa K, Takagi M, Imai K, Kashimada K, Morio T. Gonadal failure among female patients after hematopoietic stem cell transplantation for non-malignant diseases. Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology. 2019.10; 28 (4): 105-112. ( PubMed, DOI )

  36. Yoshichika Maeda, Kei Takasawa, Taku Ishii, Ayako Nagashima, Mariko Mouri, Junko Kunieda, Hiroko Morisaki, Takashi Ito, Masaaki Mori, Kenichi Kashimada, Shozaburo Doi, Tomohiro Morio. A Nonsense SMAD3 Mutation in a Girl with Familial Thoracic Aortic Aneurysm and Dissection without Joint Abnormality. Cardiology. 2019.10; 144 (1-2): 53-59. ( PubMed, DOI )

  37. Sutani Akito, Miyakawa Yuichi, Tsuji-Hosokawa Atsumi, Nomura Risa, Nakagawa Ryuichi, Nakajima Keisuke, Maru Mitsue, Aoki Yuki, Takasawa Kei, Takagi Masatoshi, Imai Kohsuke, Kashimada Kenichi, Morio Tomohiro. 非悪性疾患に対する造血幹細胞移植後の女性患者における性腺機能不全(Gonadal failure among female patients after hematopoietic stem cell transplantation for non-malignant diseases) Clinical Pediatric Endocrinology. 2019.10; 28 (4): 105-112. ( ichushi )

  38. Miyakawa Yuichi, Takasawa Kei, Matsubara Yohei, Ihara Kenji, Ohtsu Yoshiaki, Kamasaki Hotaka, Kitsuda Kazuteru, Kobayashi Hironori, Satoh Mari, Sano Sinichiro, Dateki Sumito, Mochizuki Hiroshi, Yokota Ichiro, Hasegawa Yukihiro, Kashimada Kenichi. Language delay and developmental catch-up would be a clinical feature of pseudohypoparathyroidism type 1A during childhood. ENDOCRINE JOURNAL. 2019.03; 66 (3): 215-221. ( PubMed, DOI )

  39. Miyakawa Yuichi, Takasawa Kei, Matsubara Yohei, Ihara Kenji, Ohtsu Yoshiaki, Kamasaki Hotaka, Kitsuda Kazuteru, Kobayashi Hironori, Satoh Mari, Sano Sinichiro, Dateki Sumito, Mochizuki Hiroshi, Yokota Ichiro, Hasegawa Yukihiro, Kashimada Kenichi. 言語発達遅滞とcatch-upは偽性副甲状腺機能低下症1a型の小児期における臨床的特徴(Language delay and developmental catch-up would be a clinical feature of pseudohypoparathyroidism type 1A during childhood) Endocrine Journal. 2019.03; 66 (3): 215-221. ( ichushi )

  40. Nagatsuma Misako, Takasawa Kei, Yamauchi Takeru, Nakagawa Ryuichi, Mizuno Tomoko, Tanaka Eriko, Yamamoto Kouhei, Uemura Noriko, Kashimada Kenichi, Morio Tomohiro. 脂肪腫症、腎血管性高血圧および糖尿病を呈するSchimmelpenning症候群患者における接合後のKRAS変異(A postzygotic KRAS mutation in a patient with Schimmelpenning syndrome presenting with lipomatosis, renovascular hypertension, and diabetes mellitus) Journal of Human Genetics. 2019.02; 64 (2): 177-181. ( ichushi )

  41. Akito Sutani, Hirohito Shima, Atsushi Hijikata, Susumu Hosokawa, Yuko Fukui, Kei Takasawa, Erina Suzuki, Shozaburou Doi, Tsuyoshi Shirai, Tomohiro Morio, Maki Fukami, Kenichi Kashimada. WDR11 is another causative gene for coloboma, cardiac anomaly and growth retardation in 10q26 deletion syndrome. Eur J Med Genet. 2019.01; ( PubMed, DOI )

  42. Takai S, Takasawa K, Doi S. Atypical coronary artery aneurysms due to Kawasaki disease in Noonan syndrome with a novel PTPN11 mutation. Cardiol Young. 2018.12; 4 1-3. ( DOI )

  43. Nagatsuma M, Takasawa K, Yamauchi T, Nakagawa R, Mizuno T, Tanaka E, Yamamoto K, Uemura N, Kashimada K, Morio T. A postzygotic KRAS mutation in a patient with Schimmelpenning syndrome presenting with lipomatosis, renovascular hypertension, and diabetes mellitus. Journal of human genetics. 2018.11; ( PubMed, DOI )

  44. Acerini CL, Segal D, Criseno S, Takasawa K, Nedjatian N, Röhrich S, Maghnie M.. Shared Decision-Making in Growth Hormone Therapy – Implications for Patient Care Front Endocrinol (Lausanne). 2018.11; 22 (9): 688.

  45. Atsumi Tsuji-Hosokawa, Kenichi Kashimada, Tomoko Kato, Yuya Ogawa, Risa Nomura, Kei Takasawa, Rowena Lavery, Andrea Coschiera, David Schlessinger, Vincent R Harley, Shuji Takada, Tomohiro Morio. Peptidyl arginine deiminase 2 (Padi2) is expressed in Sertoli cells in a specific manner and regulated by SOX9 during testicular development. Sci Rep. 2018.09; 8 (1): 13263. ( PubMed, DOI )

  46. Ryuichi Nakagawa, Atsumi Hosokawa-Tsuji, Yuki Aoki, Kei Takasawa, Mitsue Maru, Keisuke Nakajima, Akito Sutani, Yuichi Miyakawa, Daisuke Tomizawa, Kenichi Kashimada, Tomohiro Morio. Total body irradiation for hematopoietic stem cell transplantation during early childhood is associated with the risk for diabetes mellitus. Endocrine. 2018.06; 61 (1): 76-82. ( PubMed, DOI )

  47. Kei Takasawa, Atsumi Tsuji-Hosokawa, Shigeru Takishima, Yasunori Wada, Keisuke Nagasaki, Sumito Dateki, Chikahiko Numakura, Atsushi Hijikata, Tsuyoshi Shirai, Kenichi Kashimada, Tomohiro Morio. Clinical characteristics of adolescent cases with Type A insulin resistance syndrome caused by heterozygous mutations in the β-subunit of the insulin receptor (INSR) gene. J Diabetes. 2018.06; ( PubMed, DOI )

  48. Asami Shimbo, Kei Takasawa, Masato Nishioka, Tomohiro Morio, Masayuki Shimohira. Complications of Listeria meningitis in two immunocompetent children. Pediatr Int. 2018.05; 60 (5): 491-492. ( PubMed, DOI )

  49. Shimbo Asami, Takasawa Kei, Nishioka Masato, Morio Tomohiro, Shimohira Masayuki. 免疫正常小児2例に生じたリステリア髄膜炎(Complications of Listeria meningitis in two immunocompetent children) Pediatrics International. 2018.05; 60 (5): 491-492. ( ichushi )

  50. Teruyoshi Shimoyama, Nozomi Matsuda, Masashi Kurobe, Takehiko Hayakawa, Masato Nishioka, Masayuki Shimohira, Kei Takasawa. Colonoscopic diagnosis and reduction of recurrent intussusception owing to Henoch-Schönlein purpura without purpura. Paediatr Int Child Health. 2018.04; 1-5. ( PubMed, DOI )

  51. Kei Takasawa, Ryuichi Nakagawa, Shigeru Takishima, Kengo Moriyama, Ken Watanabe, Koji Kiyohara, Takeshi Hasegawa, Masahiro Shimohira, Kenichi Kashimada, Norio Shimizu, Tomohiro Morio. Cause of acute encephalitis/encephalopathy in Japanese children diagnosed by a rapid and comprehensive virological detection system and differences in their clinical presentations. Brain Dev.. 2018.02; 40 (2): 107-115. ( PubMed, DOI )

  52. Tomohiro Ishii, Masanori Adachi, Kei Takasawa, Satoshi Okada, Hotaka Kamasaki, Takuo Kubota, Hironori Kobayashi, Hirotake Sawada, Keisuke Nagasaki, Chikahiko Numakura, Shohei Harada, Kanshi Minamitani, Shigetaka Sugihara, Toshihiro Tajima. Incidence and Characteristics of Adrenal Crisis in Children Younger than 7 Years with 21-Hydroxylase Deficiency: A Nationwide Survey in Japan. Horm Res Paediatr. 2018.02; 89 (3): 166-171. ( PubMed, DOI )

  53. Takasawa Kei, Nakagawa Ryuichi, Takishima Shigeru, Moriyama Kengo, Watanabe Ken, Kiyohara Koji, Hasegawa Takeshi, Shimohira Masahiro, Kashimada Kenichi, Shimizu Norio, Morio Tomohiro. 迅速かつ網羅的なウイルス検査システムによって診断した日本人小児の急性脳炎/脳症の原因と臨床症状の違い(Cause of acute encephalitis/encephalopathy in Japanese children diagnosed by a rapid and comprehensive virological detection system and differences in their clinical presentations) Brain & Development. 2018.02; 40 (2): 107-115. ( ichushi )

  54. Kei Takasawa, Maki Igarashi, Makoto Ono, Akira Takemoto, Shuji Takada, Atsuyuki Yamataka, Tsutomu Ogata, Tomohiro Morio, Maki Fukami, Kenichi Kashimada. Phenotypic Variation in 46,XX Disorders of Sex Development due to the NR5A1 p.R92W Variant: A Sibling Case Report and Literature Review. Sex Dev. 2018.01; 11 (5-6): 284-288. ( PubMed, DOI )

  55. Nozomi Matsuda, Atsuko Taki, Atsumi Tsuji, Keisuke Nakajima, Kei Takasawa, Chikako Morioka, Yoshihiro Minosaki, Kikuko Oku, Kenichi Kashimada, Tomohiro Morio. Perinatal factors affecting growth and development at age 3 years in extremely low birth weight infants born small for gestational age. Clin Pediatr Endocrinol. 2018; 27 (1): 31-38. ( PubMed, DOI, ichushi )

  56. Kurokami Tsunehiko, Takasawa Reiko, Takeda Sayaka, Kurobe Masashi, Takasawa Kei, Nishioka Masato, Shimohira Masayuki. Venous thromboembolism in two adolescents with Down syndrome TURKISH JOURNAL OF PEDIATRICS. 2018; 60 (4): 429-432. ( DOI )

  57. Kurokami T, Takasawa R, Takeda S, Kurobe M, Takasawa K, Nishioka M, Shimohira M. Venous thromboembolism in two adolescents with Down syndrome. The Turkish journal of pediatrics. 2018; 60 (4): 429-432. ( PubMed )

  58. Acerini CL, Segal D, Criseno S, Takasawa K, Nedjatian N, Röhrich S, Maghnie M. Shared Decision-Making in Growth Hormone Therapy-Implications for Patient Care. Frontiers in endocrinology. 2018; 9 688. ( PubMed, DOI )

  59. Ryuichi Nakagawa, Kei Takasawa, Tzu-Wen Yeh, Kohsuke Imai, Kenichi Kashimada, Tomohiro Morio. Type 1 Diabetes Mellitus Associated with Activated Phosphoinositide-3-kinase Delta Syndrome, Type 2. J Diabetes. 2017.12; ( PubMed, DOI )

  60. Kaoru Satoh, Yoko Wakejima, Maki Gau, Tomoyuki Kiguchi, Nozomi Matsuda, Reiko Takasawa, Kei Takasawa, Masato Nishioka, Masayuki Shimohira. Risk of coronary artery lesions in young infants with Kawasaki disease: need for a new diagnostic method. Int J Rheum Dis. 2017.11; ( PubMed, DOI )

  61. Nagasaki Keisuke, Kubota Takuo, Kobayashi Hironori, Sawada Hirotake, Numakura Chikahiko, Harada Shohei, Takasawa Kei, Minamitani Kanshi, Ishii Tomohiro, Okada Satoshi, Kamasaki Hotaka, Sugihara Shigetaka, Adachi Masanori, Tajima Toshihiro. 日本における先天性中枢性甲状腺機能低下症を伴う中隔視神経形成異常症の臨床的特徴(Clinical characteristics of septo-optic dysplasia accompanied by congenital central hypothyroidism in Japan) Clinical Pediatric Endocrinology. 2017.10; 26 (4): 207-213. ( ichushi )

  62. Keisuke Nagasaki, Takuo Kubota, Hironori Kobayashi, Hirotake Sawada, Chikahiko Numakura, Shohei Harada, Kei Takasawa, Kanshi Minamitani, Tomohiro Ishii, Satoshi Okada, Hotaka Kamasaki, Shigetaka Sugihara, Masanori Adachi, Toshihiro Tajima. Clinical characteristics of septo-optic dysplasia accompanied by congenital central hypothyroidism in Japan. Clin Pediatr Endocrinol. 2017.09; 26 (4): 207-213. ( PubMed, DOI )

  63. Maki Gau, Kei Takasawa. Initial patient choice of a growth hormone device improves child and adolescent adherence to and therapeutic effects of growth hormone replacement therapy. J. Pediatr. Endocrinol. Metab.. 2017.08; 30 (9): 989-993. ( PubMed, DOI )

  64. Kobayashi Ayumi, Takasawa Reiko, Takasawa Kei, Nishioka Masato, Kaneko Masahide, Ono Hiroshi, Maekawa Takanobu, Morio Tomohiro, Shimohira Masayuki. 多剤過敏症とサイトメガロウイルスおよびBKウイルスの再活性化により重症過好酸球増多症と全身症状を呈した幼児症例(An infant case of severe hypereosinophilia and systemic symptoms with multiple drug hypersensitivity and reactivation of cytomegalovirus and BK virus) Allergology International. 2017.07; 66 (3): 479-481. ( ichushi )

  65. Atsumi Tsuji-Hosokawa, Kei Takasawa, Risa Nomura, Yuichi Miyakawa, Chikahiko Numakura, Atsushi Hijikata, Tsuyoshi Shirai, Yoshihiro Ogawa, Kenichi Kashimada, Tomohiro Morio. Molecular mechanisms of insulin resistance in 2 cases of primary insulin receptor defect-associated diseases. Pediatr Diabetes. 2017.02; ( PubMed, DOI )

  66. Miki Murakoshi, Kei Takasawa, Masato Nishioka, Masahiro Asakawa, Kenichi Kashimada, Takanobu Yoshimoto, Toshiyuki Yamamoto, Kazuhiro Takekoshi, Yoshihiro Ogawa, Masayuki Shimohira. Abdominal paraganglioma in a young woman with 1p36 deletion syndrome. Am. J. Med. Genet. A. 2017.02; 173 (2): 495-500. ( PubMed, DOI )

  67. Maki Igarashi, Kei Takasawa, Akiko Hakoda, Junko Kanno, Shuji Takada, Mami Miyado, Takashi Baba, Ken-Ichirou Morohashi, Toshihiro Tajima, Kenichiro Hata, Kazuhiko Nakabayashi, Yoichi Matsubara, Ryohei Sekido, Tsutomu Ogata, Kenichi Kashimada, Maki Fukami. Identical NR5A1 Missense Mutations in Two Unrelated 46,XX Individuals with Testicular Tissues. Hum. Mutat.. 2017.01; 38 (1): 39-42. ( PubMed, DOI )

  68. Ayumi Kobayashi, Reiko Takasawa, Kei Takasawa, Masato Nishioka, Masahide Kaneko, Hiroshi Ono, Takanobu Maekawa, Tomohiro Morio, Masayuki Shimohira. An infant case of severe hypereosinophilia and systemic symptoms with multiple drug hypersensitivity and reactivation of cytomegalovirus and BK virus. Allergol Int. 2016.11; ( PubMed, DOI )

  69. Shigeru Takishima, Keisuke Nakajima, Risa Nomura, Atsumi Tsuji-Hosokawa, Nozomi Matsuda, Yohei Matsubara, Makoto Ono, Kentaro Miyai, Kei Takasawa, Tomohiro Morio, Yukihiro Hasegawa, Kenichi Kashimada. Lower body weight and BMI at birth were associated with early adiposity rebound in 21-hydroxylase deficiency patients. Endocr. J.. 2016.11; 63 (11): 983-990. ( PubMed, DOI )

  70. Kei Takasawa, Yuichi Miyakawa, Atsushi Masamune, Kenichi Kashimada, Masayuki Shimohira. Fibrocalculous pancreatic diabetes in a Japanese girl with severe motor and intellectual disabilities. Acta Diabetol. 2016.06; 53 (3): 507-510. ( PubMed, DOI )

  71. Kei Takasawa, Sayaka Takeda, Masato Nishioka, Hiroshi Sakuma, Tomohiro Morio, Masayuki Shimohira. Steroid-responsive Status Epilepticus Caused by Human Parvovirus B19 Encephalitis. Pediatr. Infect. Dis. J.. 2016.02; 35 (2): 227-228. ( PubMed, DOI )

  72. Mami Miyado, Masafumi Inui, Maki Igarashi, Yuko Katoh-Fukui, Kei Takasawa, Akiko Hakoda, Junko Kanno, Kenichi Kashimada, Kenji Miyado, Moe Tamano, Tsutomu Ogata, Shuji Takada, Maki Fukami. The p.R92W variant of NR5A1/Nr5a1 induces testicular development of 46,XX gonads in humans, but not in mice: phenotypic comparison of human patients and mutation-induced mice. Biol Sex Differ. 2016; 7 56. ( PubMed, DOI )

  73. Kei Takasawa, Shigeru Takishima, Chikako Morioka, Masato Nishioka, Hirofumi Ohashi, Yoko Aoki, Masayuki Shimohira, Kenichi Kashimada, Tomohiro Morio. Improved growth velocity of a patient with Noonan-like syndrome with loose anagen hair (NS/LAH) without growth hormone deficiency by low-dose growth hormone therapy. Am. J. Med. Genet. A. 2015.10; 167A (10): 2425-2429. ( PubMed, DOI )

  74. R Kawakita, Y Hosokawa, R Fujimaru, N Tamagawa, T Urakami, K Takasawa, K Moriya, H Mizuno, Y Maruo, M Takuwa, H Nagasaka, Y Nishi, Y Yamamoto, K Aizu, T Yorifuji. Molecular and clinical characterization of glucokinase maturity-onset diabetes of the young (GCK-MODY) in Japanese patients. Diabet. Med.. 2014.11; 31 (11): 1357-1362. ( PubMed, DOI )

  75. Kei Takasawa, Makoto Ono, Atsushi Hijikata, Yohei Matsubara, Noriyuki Katsumata, Masatoshi Takagi, Tomohiro Morio, Osamu Ohara, Kenichi Kashimada, Shuki Mizutani. Two novel HSD3B2 missense mutations with diverse residual enzymatic activities for Δ5-steroids. Clin. Endocrinol. (Oxf). 2014.06; 80 (6): 782-789. ( PubMed, DOI )

  76. Kei Takasawa, Kenichi Kashimada, Emanuele Pelosi, Masatoshi Takagi, Tomohiro Morio, Hiroshi Asahara, David Schlessinger, Shuki Mizutani, Peter Koopman. FOXL2 transcriptionally represses Sf1 expression by antagonizing WT1 during ovarian development in mice. FASEB J.. 2014.05; 28 (5): 2020-2028. ( PubMed, DOI )

  77. Yohei Matsubara, Makoto Ono, Kentaro Miyai, Fumihiko Takizawa, Kei Takasawa, Toshikazu Onishi, Kenichi Kashimada, Shuki Mizutani. Longitudinal analysis of growth and body composition of Japanese 21-OHD patients in childhood. Endocr. J.. 2013; 60 (2): 149-154. ( PubMed, DOI )

  78. Takasawa K, Ono M, Miyai K, Matsubara Y, Takizawa F, Onishi T, Kashimada K, Mizutani S.. Initial high dose hydrocortisone (HDC) treatment for 21-hydroxylase deficiency (21-OHD) does not affect linear growth during the first three years of life. Endocrine Journal. 2012; 59 (11): 1001-1006. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  1. Kei Takasawa. Management of Congenital Adrenal Hyperplasia (CAH) during adolescence and transition to adult care. APPES-ISPAE Joint Meeting 2024 (The 13th Biennial Scientific Meeting of APPES, co-organised by the Asia Pacific Pediatric Endocrine Society (APPES) and Indian Society for Pediatric and Adolescent Endocrinology (ISPAE)) 2024.10.01 New Delhi, India

  2. Takasawa K. Patient choice of growth hormone device improves child and adolescent adherence, and effects of growth hormone therapy. Novo Nordisk Global Expert Panel Meeting: Role of Patient Autonomy and Shared Decision Making 2017.10.08 London, UK

  3. Kei Takasawa, et al.. Mortality and incidence of misidentification of sex assignment in patients with congenital 21-hydroxylase deficiency identified by a newborn screening program in Japan (2001-2015).. The 9th biennial scientific meeting of the Asia Pacific Paediatric Endocrine Society 2016.11.18 Tokyo, Japan

  4. Maki Igarashi, Kei Takasawa, Akiko Hakoda, Junko Kanno, Shuji Takada, Mami Miyado, Toshihiro Tajima, Ryohei Sekido, Tsutomu Ogata, Kenichi Kashimada, Maki Fukami. Identical NR5A1 Missense Mutations in Two Unrelated 46, XX Individuals with Testicular Tissues. The 9th Biennial Scientific Meeting of the Asia Pacific Endocrine Society/ The 50th Annual Meeting of the Japanese Society for Pediatric Endocrinology 2016.11.17 Tokyo, Japan

  5. Atsumi Tsuji, Kei Takasawa, Risa Nomura, Yuichi Miyakawa, Chikahiko Numakura, Atsushi Hijikata, Tsuyoshi Shirai, Yoshihiro Ogawa, Kashimada, Tomohiro Morio. Molecular mechanisms of insulin resistance in two cases of primary insulin receptor defect-associated diseases. The 9th biennial scientific meeting of the Asia Pacific Paediatric Endocrine Society 2016.10.19 Tokyo, Japan

  6. Takasawa K, Kashimada K, Pelosi E, Takagi M, Morio T, Asahara H, Schlessinger D, Mizutani S, Koopman P. FOXL2 transcriptionally represses Sf1 expression by antagonizing WT1 during ovarian development in mice.. 7th International Symposium on Vertebrate Sex Determination 2015.04.13 Hawaii

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Awards & Honors 【 display / non-display

  • International Society of Endocrinology (ISE) Travel Grant,International Society of Endocrinology ,2014.06

Others 【 display / non-display

  • Saiatama Endocrinologist Research Meeting,2024.07

  • Tokyo Endocrinologist Research Meeting,2024.04

  • CPE Meeting in KANTO,2024.03