Personnel Information

写真a

IKEDA Kenji


Job title

Associate Professor

Homepage URL

http://www.tmd.ac.jp/grad/cme/index.html

Research Areas, Keywords

Beige fat, Brown fat, regulation of the energy expenditure, obesity, diabetes

Profile

Current my workis focuing on role of the thermogenic fat(Beige adipocytes and Brown adipocytes)physiological function.Aim is to develop the novel treatment to obesity and diabetes via thermogeni fat.
To the head of this page.▲

Graduating School 【 display / non-display 】

  • Tokyo Medical and Dental University, Faculty of Medicine, 2005.03, Graduated

To the head of this page.▲

Graduate School 【 display / non-display 】

  • Tokyo Medical and Dental University, Doctor's Course, 2015.03, Completed

To the head of this page.▲

Campus Career 【 display / non-display 】

  • 2019.04
    -
    2019.10
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Internal Medicine， Diabetes, Endocrinology and Metabolism， Junior Associate Professor
  • 2019.04
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Advanced Therapeutic Sciences， Molecular Endocrinology and Metabolism， Junior Associate Professor
  • 2019.11
    -
    2021.09
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Internal Medicine， Diabetes, Endocrinology and Metabolism， Junior Associate Professor
  • 2021.10
    -
    2022.03
    Tokyo Medical and Dental University， Tokyo Medical and Dental University， Division of Clinical Medicine， Department of Internal Medicine， Diabetes, Endocrinology and Metabolism， Junior Associate Professor
  • 2022.04
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Advanced Therapeutic Sciences， Molecular Endocrinology and Metabolism， Associate Professor
To the head of this page.▲

External Career 【 display / non-display 】

  • 2015.04
    -
    2019.03
    University of California, San Francisco, Diabetes Center, Postdoc fellow
To the head of this page.▲
 

Published Papers & Misc 【 display / non-display 】

  1. Ikeda Kenji, Yamada Tetsuya. カルシウム無益サイクリングによる脂肪組織熱産生(Adipose tissue thermogenesis by calcium futile cycling) The Journal of Biochemistry. 2022.10; 172 (4): 197-203. ( ichushi )

  2. Ikeda K, Tajima K, Tanabe Y, Poon ASY, Kajimura S. Activation of UCP1-Independent Ca2+ Cycling Thermogenesis by Wireless Optogenetics. Methods in Molecular Biology . 2022.02; 2448 131-139. ( PubMed )

  3. Takeshi Yoneshiro, Naoya Kataoka, Jacquelyn M Walejko, Kenji Ikeda, Zachary Brown, Momoko Yoneshiro, Scott B Crown, Tsuyoshi Osawa, Juro Sakai, Robert W McGarrah, Phillip J White, Kazuhiro Nakamura, Shingo Kajimura. Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever. Elife. 2021.05; 10 ( PubMed, DOI )

  4. Crystal S Conn, Haojun Yang, Harrison J Tom, Kenji Ikeda, Juan A Oses-Prieto, Hieu Vu, Yasuo Oguri, Supna Nair, Ryan M Gill, Shingo Kajimura, Ralph J DeBerardinis, Alma L Burlingame, Davide Ruggero. The major cap-binding protein eIF4E regulates lipid homeostasis and diet-induced obesity. Nat Metab. 2021.02; 3 (2): 244-257. ( PubMed, DOI )

  5. Sponton Carlos H., Hosono Takashi, Taura Junki, Jedrychowski Mark P., Yoneshiro Takeshi, Wang Qiang, Takahashi Makoto, Matsui Yumi, Ikeda Kenji, Oguri Yasuo, Tajima Kazuki, Shinoda Kosaku, Pradhan Rachana N., Chen Yong, Brown Zachary, Roberts Lindsay S., Ward Carl C., Taoka Hiroki, Yokoyama Yoko, Watanabe Mitsuhiro, Karasawa Hiroshi, Nomura Daniel K., Kajimura Shingo. The regulation of glucose and lipid homeostasis viaPLTPas a mediator ofBAT-liver communication EMBO Reports. 2020.09; 21 (9):

  6. Oguri Yasuo, Shinoda Kosaku, Kim Hyeonwoo, Alba Diana L., Bolus W. Reid, Wang Qiang, Brown Zachary, Pradhan Rachana N., Tajima Kazuki, Yoneshiro Takeshi, Ikeda Kenji, Chen Yong, Cheang Rachel T., Tsujino Kazuyuki, Kim Caroline R., Greiner Vanille Juliette, Datta Ritwik, Yang Christopher D., Atabai Kamran, McManus Michael T., Koliwad Suneil K., Spiegelman Bruce M., Kajimura Shingo. CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling Cell. 2020.08; 182 (3): 563-+. ( PubMed, DOI )

  7. Nakano Y, Komiya C, Shimizu H, Mishima H, Shiba K, Tsujimoto K, Ikeda K, Kashimada K, Dateki S, Yoshiura KI, Ogawa Y, Yamada T. A case of ezetimibe-effective hypercholesterolemia with a novel heterozygous variant in ABCG5. Endocrine journal. 2020.07; ( PubMed, DOI )

  8. Ikeda Kenji, Yamada Tetsuya. UCP1 Dependent and Independent Thermogenesis in Brown and Beige Adipocytes FRONTIERS IN ENDOCRINOLOGY. 2020.07; 11 498. ( PubMed, DOI )

  9. Tajima Kazuki, Ikeda Kenji, Tanabe Yuji, Thomson Ella A., Yoneshiro Takeshi, Oguri Yasuo, Ferro Marc D., Poon Ada S. Y., Kajimura Shingo. Wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis Nature Communications. 2020.04; 11 (1): 1730. ( PubMed, DOI )

  10. Kazuki Tajima, Kenji Ikeda, Hsin-Yi Chang, Chih-Hsiang Chang, Takeshi Yoneshiro, Yasuo Oguri, Heejin Jun, Jun Wu, Yasushi Ishihama, Shingo Kajimura. Mitochondrial lipoylation integrates age-associated decline in brown fat thermogenesis Nature Metabolism. 2019.09; 1 886-898. ( DOI )

  11. Yoneshiro Takeshi, Wang Qiang, Tajima Kazuki, Matsushita Mami, Maki Hiroko, Igarashi Kaori, Dai Zhipeng, White Phillip J., McGarrah Robert W., Ilkayeva Olga R., Deleye Yann, Oguri Yasuo, Kuroda Mito, Ikeda Kenji, Li Huixia, Ueno Ayano, Ohishi Maki, Ishikawa Takamasa, Kim Kyeongkyu, Chen Yong, Sponton Carlos Henrique, Pradhan Rachana N., Majd Homa, Greiner Vanille Juliette, Yoneshiro Momoko, Brown Zachary, Chondronikola Maria, Takahashi Haruya, Goto Tsuyoshi, Kawada Teruo, Sidossis Labros, Szoka Francis C., McManus Michael T., Saito Masayuki, Soga Tomoyoshi, Kajimura Shingo. BCAA catabolism in brown fat controls energy homeostasis through SLC25A44 NATURE. 2019.08; 572 (7771): 614-+. ( PubMed, DOI )

  12. Conn Crystal S., Yang Haojun, Ikeda Kenji, Oses-Prieto Juan A., Nair Supna, Parker Matt, Ventura Patrick B., Villeda Saul A., Kajimura Shingo, Burlingame Alma L., Ruggero Davide. eIF4E selective control for metabolic fitness and healthspan MOLECULAR & CELLULAR PROTEOMICS. 2019.08; 18 (8): S76.

  13. Chen Yong, Ikeda Kenji, Yoneshiro Takeshi, Scaramozza Annarita, Tajima Kazuki, Wang Qiang, Kim Kyeongkyu, Shinoda Kosaku, Sponton Carlos Henrique, Brown Zachary, Brack Andrew, Kajimura Shingo. Thermal stress induces glycolytic beige fat formation via a myogenic state NATURE. 2019.01; 565 (7738): 180-+. ( PubMed, DOI )

  14. Lu Xiaodan, Altshuler-Keylin Svetlana, Wang Qiang, Chen Yong, Sponton Carlos Henrique, Ikeda Kenji, Maretich Pema, Yoneshiro Takeshi, Kajimura Shingo. Mitophagy controls beige adipocyte maintenance through a Parkin-dependent and UCP1-independent mechanism SCIENCE SIGNALING. 2018.04; 11 (527): ( PubMed, DOI )

  15. Ikeda Kenji, Maretich Pema, Kajimura Shingo. The Common and Distinct Features of Brown and Beige Adipocytes TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2018.03; 29 (3): 191-200. ( PubMed, DOI )

  16. Hasegawa Yutaka, Ikeda Kenji, Chen Yong, Alba Diana L., Stifler Daniel, Shinoda Kosaku, Hosono Takashi, Maretich Pema, Yang Yangyu, Ishigaki Yasushi, Chi Jingyi, Cohen Paul, Koliwad Suneil K., Kajimura Shingo. Repression of Adipose Tissue Fibrosis through a PRDM16-GTF2IRD1 Complex Improves Systemic Glucose Homeostasis CELL METABOLISM. 2018.01; 27 (1): 180-+. ( PubMed, DOI )

  17. Kenji Ikeda, Qianqian Kang, Takeshi Yoneshiro, Joao Paulo Camporez, Hiroko Maki, Mayu Homma, Kosaku Shinoda, Yong Chen, Xiaodan Lu, Pema Maretich, Kazuki Tajima, Kolapo M Ajuwon, Tomoyoshi Soga, Shingo Kajimura. UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis. Nat. Med.. 2017.12; 23 (12): 1454-1465. ( PubMed, DOI )

  18. Komiya Chikara, Tanaka Miyako, Tsuchiya Kyoichiro, Shimazu Noriko, Mori Kentaro, Furuke Shunsaku, Miyachi Yasutaka, Shiba Kumiko, Yamaguchi Shinobu, Ikeda Kenji, Ochi Kozue, Nakabayashi Kazuhiko, Hata Ken-ichiro, Itoh Michiko, Suganami Takayoshi, Ogawa Yoshihiro. Antifibrotic effect of pirfenidone in a mouse model of human nonalcoholic steatohepatitis SCIENTIFIC REPORTS. 2017.03; 7 44754. ( PubMed, DOI )

  19. Miyako Tanaka, Kenji Ikeda, Takayoshi Suganami, Chikara Komiya, Kozue Ochi, Ibuki Shirakawa, Miho Hamaguchi, Satoshi Nishimura, Ichiro Manabe, Takahisa Matsuda, Kumi Kimura, Hiroshi Inoue, Yutaka Inagaki, Seiichiro Aoe, Sho Yamasaki, Yoshihiro Ogawa. Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis. Nature Communications. 2014.09; 5 4982. ( PubMed, DOI )

▼display all

To the head of this page.▲

Others 【 display / non-display 】

  • The surprisingly complex inner workings of an endocrine tumor，2024.03

To the head of this page.▲