Personnel Information

写真a

SHIWAKU Hiroki


Job title

Associate Professor

Campus Career 【 display / non-display

  • 2015.04
    -
    2016.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Cognitive and Behavioral Medicine, Psychiatry and Behavioral Sciences, Visiting Lecturer
  • 2017.01
    -
    2017.12
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Cognitive and Behavioral Medicine, Psychiatry and Behavioral Sciences, Senior Resident
  • 2018.04
    -
    2019.03
    Tokyo Medical and Dental University, (Old Organization)Medical Hospital, Hospital Departments, Department of Neurology, Neurosurgery,Psychiatry and Anesthesiology, Psychiatry, Project Assistant Professor
  • 2019.04
    -
    2022.09
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Cognitive and Behavioral Medicine, Psychiatry and Behavioral Sciences, Assistant Professor
  • 2022.10
    -
    2022.09
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Cognitive and Behavioral Medicine, Psychiatry and Behavioral Sciences, Associate Professor
  • 2022.10
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Cognitive and Behavioral Medicine, Psychiatry and Behavioral Sciences, Associate Professor

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Published Papers & Misc 【 display / non-display

  1. Tamura Takehiro, Sugihara Genichi, Okita Kyoji, Mukai Yohei, Matsuda Hiroshi, Shiwaku Hiroki, Takagi Shunsuke, Daisaki Hiromitsu, Tateishi Ukihide, Takahashi Hidehiko. Dopamine dysfunction in depression: application of texture analysis to dopamine transporter single-photon emission computed tomography imaging Translational psychiatry. 2022.08; 12 (1): 309. ( PubMed, DOI )

  2. Shiwaku Hiroki, Katayama Shingo, Kondo Kanoh, Nakano Yuri, Tanaka Hikari, Yoshioka Yuki, Fujita Kyota, Tamaki Haruna, Takebayashi Hironao, Terasaki Omi, Nagase Yukihiro, Nagase Teruyoshi, Kubota Tetsuo, Ishikawa Kinya, Okazawa Hitoshi, Takahashi Hidehiko. Autoantibodies against NCAM1 from patients with schizophrenia cause schizophrenia-related behavior and changes in synapses in mice CELL REPORTS MEDICINE. 2022.04; 3 (4): 100597. ( PubMed, DOI )

  3. Katayama S, Kubota T, Takahashi H, Shiwaku H. Anti-rods/rings autoantibodies in a patient with pancreatic injury. Autoimmunity reviews. 2022.01; 21 (1): 102922. ( PubMed, DOI )

  4. Jin Meihua, Shiwaku Hiroki, Tanaka Hikari, Obita Takayuki, Ohuchi Sakurako, Yoshioka Yuki, Jin Xiaocen, Kondo Kanoh, Fujita Kyota, Homma Hidenori, Nakajima Kazuyuki, Mizuguchi Mineyuki, Okazawa Hitoshi. Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation NATURE COMMUNICATIONS. 2021.11; 12 (1): 6565. ( PubMed, DOI )

  5. Homma Hidenori, Tanaka Hikari, Jin Meihua, Jin Xiaocen, Huang Yong, Yoshioka Yuki, Bertens Christian J. F., Tsumaki Kohei, Kondo Kanoh, Shiwaku Hiroki, Tagawa Kazuhiko, Akalsu Hiroyasu, Atsuta Naoki, Katsuno Masahisa, Furukawa Katsutoshi, Ishiki Aiko, Waragai Masaaki, Ohtomo Gaku, Iwata Atsushi, Yokota Takanori, Inoue Haruhisa, Arai Hiroyuki, Sobue Gen, Sone Masaki, Fujita Kyota, Okazawa Hitoshi. DNA damage in embryonic neural stem cell determines FTLDs' fate via early-stage neuronal necrosis LIFE SCIENCE ALLIANCE. 2021.07; 4 (7): ( PubMed, DOI )

  6. Shiwaku Hiroki, Doi Satomi, Miyajima Miho, Matsumoto Yukiko, Fujino Junya, Hirai Nobuhide, Jitoku Daisuke, Takagi Shunsuke, Tamura Takehiro, Maruo Takashi, Shidei Yuki, Kobayashi Nanase, Ichihashi Masanori, Noguchi Shiori, Oohashi Kanako, Takeuchi Takashi, Sugihara Genichi, Okada Takayuki, Fujiwara Takeo, Takahashi Hidehiko. COVID-19パンデミックにおける医療従事者の精神的および社会的ストレスを評価するための新しい簡易なスクリーニング尺度、Tokyo Metropolitan Distress Scale for Pandemic(TMDP)(Novel brief screening scale, Tokyo Metropolitan Distress Scale for Pandemic(TMDP), for assessing mental and social stress of medical personnel in COVID-19 pandemic) Psychiatry and Clinical Neurosciences. 2021.02; 75 (1-2): 24-25. ( ichushi )

  7. Shiwaku Hiroki, Doi Satomi, Miyajima Miho, Matsumoto Yukiko, Fujino Junya, Hirai Nobuhide, Jitoku Daisuke, Takagi Shunsuke, Tamura Takehiro, Maruo Takashi, Shidei Yuki, Kobayashi Nanase, Ichihashi Masanori, Noguchi Shiori, Oohashi Kanako, Takeuchi Takashi, Sugihara Genichi, Okada Takayuki, Fujiwara Takeo, Takahashi Hidehiko. Novel brief screening scale, Tokyo Metropolitan Distress Scale for Pandemic (TMDP), for assessing mental and social stress of medical personnel in COVID-19 pandemic PSYCHIATRY AND CLINICAL NEUROSCIENCES. 2021.01; 75 (1): 24-25. ( PubMed, DOI )

  8. Shiwaku Hiroki, Fujita Masako, Takahashi Hidehiko. Benzodiazepines Reduce Relapse and Recurrence Rates in Patients with Psychotic Depression JOURNAL OF CLINICAL MEDICINE. 2020.06; 9 (6): ( PubMed, DOI )

  9. Shiwaku H, Nakano Y, Kato M, Takahashi H. Detection of autoantibodies against GABA<sub>A</sub>Rα1 in patients with schizophrenia. Schizophrenia research. 2019.12; 216 543-546. ( PubMed, DOI )

  10. Tamura T, Shiwaku H, Jitoku D, Kurumaji A. Effect of Tandospirone, a Partial Agonist of the 5-HT1A Receptor, in a Patient With Chronic Poststroke Emotional Incontinence With Anxiousness. The primary care companion for CNS disorders. 2019.09; 21 (5): ( PubMed, DOI )

  11. Fujita Kyota, Mao Ying, Uchida Shigenori, Chen Xigui, Shiwaku Hiroki, Tamura Takuya, Ito Hikaru, Homma Hidenori, Tagawa Kazuhiko, Okazawa Hitoshi. 発達期のYAPdeltaCは脊髄小脳失調症1型モデルマウスにおける成体の病理を決定する(Developmental YAPdeltaC determines adult pathology in a mouse model of spinocerebellar ataxia type 1) 臨床神経学. 2018.12; 58 (Suppl.): S200. ( ichushi )

  12. Shiwaku Hiroki, Nishikawa Toru. Paroxetine ameliorates whole-body allodynia EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2018.07; 74 (7): 979-980. ( PubMed, DOI )

  13. Shiwaku Hiroki, Kimura Yukio, Narushima Kenji, Matsuda Hiroshi, Nishikawa Toru. Unilateral Atonia and Asymmetric Cholinergic Dysfunction in Ross Syndrome BIOLOGICAL PSYCHIATRY. 2018.01; 83 (2): E30-E31. ( PubMed, DOI )

  14. Fujita Kyota, Mao Ying, Uchida Shigenori, Chen Xigui, Shiwaku Hiroki, Tamura Takuya, Ito Hikaru, Watase Kei, Homma Hidenori, Tagawa Kazuhiko, Sudol Marius, Okazawa Hitoshi. Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1 NATURE COMMUNICATIONS. 2017.11; 8 (1): 1864. ( PubMed, DOI )

  15. Shiwaku Hiroki, Umino Asami, Umino Masakazu, Nishikawa Toru. Phencyclidine-induced dysregulation of primary cilia in the rodent brain BRAIN RESEARCH. 2017.11; 1674 62-69. ( PubMed, DOI )

  16. Shiwaku Hiroki, Masaki Hidekazu, Yasugi Daisuke, Narushima Kenji. A Case of a Depressed Patient With Major Titanium Cranial Base Reconstruction Successfully Treated by ECT AMERICAN JOURNAL OF PSYCHIATRY. 2015.10; 172 (10): 1024-1025. ( PubMed, DOI )

  17. Ito H., Shiwaku H., Yoshida C., Homma H., Luo H., Chen X., Fujita K., Musante L., Fischer U., Frints S. G. M., Romano C., Ikeuchi Y., Shimamura T., Imoto S., Miyano S., Muramatsu S-i, Kawauchi T., Hoshino M., Sudol M., Arumughan A., Wanker E. E., Rich T., Schwartz C., Matsuzaki F., Bonni A., Kalscheuer V. M., Okazawa H.. In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells MOLECULAR PSYCHIATRY. 2015.04; 20 (4): 459-471. ( DOI )

  18. Shiwaku H., Okazawa H.. Impaired DNA Damage Repair as a Common Feature of Neurodegenerative Diseases and Psychiatric Disorders CURRENT MOLECULAR MEDICINE. 2015; 15 (2): 119-128.

  19. Barclay Sam S., Tamura Takuya, Ito Hikaru, Fujita Kyota, Tagawa Kazuhiko, Shimamura Teppei, Katsuta Asuka, Shiwaku Hiroki, Sone Masaki, Imoto Seiya, Miyano Satoru, Okazawa Hitoshi. Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1 HUMAN MOLECULAR GENETICS. 2014.03; 23 (5): 1345-1364. ( PubMed, DOI )

  20. Shiwaku Hiroki, Yagishita Saburo, Eishi Yoshinobu, Okazawa Hitoshi. Bergmann glia are reduced in spinocerebellar ataxia type 1 NEUROREPORT. 2013.08; 24 (11): 620-625. ( PubMed, DOI )

  21. Li Chan, Ito Hikaru, Fujita Kyota, Shiwaku Hiroki, Qi Yunlong, Tagawa Kazuhiko, Tamura Takuya, Okazawa Hitoshi. Sox2 Transcriptionally Regulates Pqbp1, an Intellectual Disability-Microcephaly Causative Gene, in Neural Stem Progenitor Cells PLOS ONE. 2013.07; 8 (7): e68627. ( PubMed, DOI )

  22. Fujita Kyota, Nakamura Yoko, Oka Tsutomu, Ito Hikaru, Tamura Takuya, Tagawa Kazuhiko, Sasabe Toshikazu, Katsuta Asuka, Motoki Kazumi, Shiwaku Hiroki, Sone Masaki, Yoshida Chisato, Katsuno Masahisa, Eishi Yoshinobu, Murata Miho, Taylor J. Paul, Wanker Erich E., Kono Kazuteru, Tashiro Satoshi, Sobue Gen, La Spada Albert R., Okazawa Hitoshi. A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases NATURE COMMUNICATIONS. 2013.05; 4 1816. ( PubMed, DOI )

  23. Nakamura Yoko, Tagawa Kazuhiko, Oka Tsutomu, Sasabe Toshikazu, Ito Hikaru, Shiwaku Hiroki, La Spada Albert R., Okazawa Hitoshi. Ataxin-7 associates with microtubules and stabilizes the cytoskeletal network HUMAN MOLECULAR GENETICS. 2012.03; 21 (5): 1099-1110. ( PubMed, DOI )

  24. Tamura Takuya, Sone Masaki, Barclay Sam, Ito Hikaru, Shiwaku Hiroki, Tagawa Kazuhiko, Okazawa Hitoshi. DNA damage repair in Spinocerebellar ataxia 1 NEUROSCIENCE RESEARCH. 2011; 71 E193. ( DOI )

  25. 榎戸 靖, 田村 拓也, 伊藤 比加瑠, 小室 晃彦, 塩飽 裕紀, Wanker Erich E., 岡澤 均. 変異ハンチンチン蛋白質によるDNA修復酵素Ku70の阻害(Mutant Huntingtin impairs Ku70-mediated DNA repair) 神経化学. 2010.08; 49 (2-3): 505. ( ichushi )

  26. Shiwaku Hiroki, Yoshimura Natsue, Tamura Takuya, Sone Masaki, Ogishima Soichi, Watase Kei, Tagawa Kazuhiko, Okazawa Hitoshi. Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity EMBO JOURNAL. 2010.07; 29 (14): 2446-2460. ( PubMed, DOI )

  27. Enokido Yasushi, Tamura Takuya, Ito Hikaru, Arumughan Anup, Komuro Akihiko, Shiwaku Hiroki, Sone Masaki, Foulle Raphaele, Sawada Hirohide, Ishiguro Hiroshi, Ono Tetsuya, Murata Miho, Kanazawa Ichiro, Tomilin Nikolai, Tagawa Kazuhiko, Wanker Erich E., Okazawa Hitoshi. Mutant huntingtin impairs Ku70-mediated DNA repair JOURNAL OF CELL BIOLOGY. 2010.05; 189 (3): 425-443. ( PubMed, DOI )

  28. Enokido Yasushi, Tamura Takuya, Ito Hikaru, Komuro Akihiko, Shiwaku Hiroki, Wanker Erich E., Okazawa Hitoshi. Mutant Huntingtin impairs Ku70-mediated DNA repair NEUROSCIENCE RESEARCH. 2010; 68 E94. ( DOI )

  29. Chin Ji-Hyang, Shiwaku Hiroki, Goda Olga, Komuro Akihiko, Okazawa Hitoshi. Neural stem cells express Oct-3/4 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2009.10; 388 (2): 247-251. ( PubMed, DOI )

  30. Sone Masaki, Uchida Atsuko, Komatsu Ayumi, Suzuki Emiko, Ibuki Ikue, Asada Megumi, Shiwaku Hiroki, Tamura Takuya, Hoshino Mikio, Okazawa Hitoshi, Nabeshima Yo-ichi. Loss of yata, a Novel Gene Regulating the Subcellular Localization of APPL, Induces Deterioration of Neural Tissues and Lifespan Shortening PLOS ONE. 2009.02; 4 (2): e4466. ( PubMed, DOI )

  31. Takahashi Keiko, Yoshina Sawako, Masashi Maekawa, Ito Wakana, Inoue Takao, Shiwaku Hiroki, Arai Hiroyuki, Mitani Shohei, Okazawa Hitoshi. Nematode Homologue of PQBP1, a Mental Retardation Causative Gene, Is Involved in Lipid Metabolism PLOS ONE. 2009.01; 4 (1): e4104. ( PubMed, DOI )

  32. Shiwaku Hiroki, Sone Masaki, Tamura Takuya, Okazawa Hitoshi. 新規微小管関連蛋白質Maxcellの同定と性状解析(Identification and characterization of Maxcell, a novel microtubule-associated protein) Neuroscience Research. 2008.07; 61 (Suppl.1): S69. ( ichushi )

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Conference Activities & Talks 【 display / non-display

  1. H. Shiwaku. Detection of autoantibodies against GABAARα1 in patients with schizophrenia. Australasian Neuroscience society annual scientific meeting 2019.11.04 Aderaide

  2. 榎戸 靖, 田村 拓也, 伊藤 比加瑠, 小室 晃彦, 塩飽 裕紀, Wanker Erich E., 岡澤 均. 変異ハンチンチン蛋白質によるDNA修復酵素Ku70の阻害(Mutant Huntingtin impairs Ku70-mediated DNA repair). 神経化学 2010.08.01