論文・総説 - 加納　嘉人

1. Ogasawara, N; Kano, Y; Yoneyama, Y; Kobayashi, S; Watanabe, S; Kirino, S; Velez-Bravo, FD; Hong, Y; Ostapiuk, A; Lutsik, P; Onishi, I; Yamauchi, S; Hiraguri, Y; Ito, G; Kinugasa, Y; Ohashi, K; Watanabe, M; Okamoto, R; Tejpar, S; Yui, S. Discovery of non-genomic drivers of YAP signaling modulating the cell plasticity in CRC tumor lines ISCIENCE. 2024.03; 27 (3): 109247. ( PubMed, DOI )

2. Naito T, Noji R, Kugimoto T, Kuroshima T, Tomioka H, Fujiwara S, Suenaga M, Harada H, Kano Y. The Efficacy of Immunotherapy and Clinical Utility of Comprehensive Genomic Profiling in Adenoid Cystic Carcinoma of Head and Neck. Medicina (Kaunas, Lithuania). 2023.12; 59 (12): ( PubMed, DOI )

3. Noji R, Tohyama K, Kugimoto T, Kuroshima T, Hirai H, Tomioka H, Michi Y, Tasaki A, Ohno K, Ariizumi Y, Onishi I, Suenaga M, Mori T, Okamoto R, Yoshimura R, Miura M, Asakage T, Miyake S, Ikeda S, Harada H, Kano Y. Comprehensive Genomic Profiling Reveals Clinical Associations in Response to Immune Therapy in Head and Neck Cancer. Cancers. 2022.07; 14 (14): ( PubMed, DOI )

4. Gebregiworgis T*, Kano Y* (*contributed equally), St-Germain J, Radulovich N, Udaskin ML, Mentes A, Huang R, Poon BPK, He W, Valencia-Sama I, Robinson CM, Huestis M, Miao J, Yeh JJ, Zhang ZY, Irwin MS, Lee JE, Tsao MS, Raught B, Marshall CB, Ohh M, Ikura M. The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors. Nature communications. 2021.11; 12 (1): 6274. ( PubMed, DOI )

5. Yoshihito Kano, Teklab Gebregiworgis, Christopher B Marshall, Nikolina Radulovich, Betty P K Poon, Jonathan St-Germain, Jonathan D Cook, Ivette Valencia-Sama, Benjamin M M Grant, Silvia Gabriela Herrera, Jinmin Miao, Brian Raught, Meredith S Irwin, Jeffrey E Lee, Jen Jen Yeh, Zhong-Yin Zhang, Ming-Sound Tsao, Mitsuhiko Ikura, Michael Ohh. Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation. Nature communications. 2019.01; 10 (1): 224. ( PubMed, DOI )

6. Yoshihito Kano, Jonathan D Cook, Jeffrey E Lee, Michael Ohh. New structural and functional insight into the regulation of Ras. Semin. Cell Dev. Biol. 2016.10; 58 70-78. ( PubMed, DOI )

7. Severa Bunda, Kelly Burrell, Pardeep Heir, Lifan Zeng, Amir Alamsahebpour, Yoshihito Kano, Brian Raught, Zhong-Yin Zhang, Gelareh Zadeh, Michael Ohh. Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis. Nature Communications. 2015.11; 6 8859. ( PubMed, DOI )

8. Yoshihito Kano, Kiichiro Tsuchiya, Xiu Zheng, Nobukatsu Horita, Keita Fukushima, Shuji Hibiya, Yuhki Yamauchi, Tatsunori Nishimura, Kunihiko Hinohara, Noriko Gotoh, Shinji Suzuki, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein. Biochem. Biophys. Res. Commun.. 2013.03; 432 (1): 175-181. ( PubMed, DOI )

9. Su Y, Ouchi R, Daroonpan P, Hamagaki M, Ikeda T, Rika N, Nishii N, Tsushima F, Kano Y, Asakage T, Noguchi M, Harada H, Azuma M. Stratification of the immunotypes of tongue squamous cell carcinoma to improve prognosis and the response to immune checkpoint inhibitors. Cancer immunology, immunotherapy : CII. 2025.03; 74 (4): 130. ( PubMed, DOI )

10. Morikawa, R; Nitta, K; Yasuda, S; Kano, Y; Noji, R; Aoyama, S; Sato, S; Ikeda, S; Okamoto, R; Nagata, M; Mori, T; Suenaga, M. Identification of risk factors for gastrointestinal immune-related adverse events associated with immune check point inhibitors EXPERT OPINION ON DRUG SAFETY. 2024.12; 1-8. ( PubMed, DOI )

11. Suenaga M, Yamauchi S, Morikawa R, Noji R, Kano Y, Tokunaga M, Kinugasa Y. Chemotherapy and COVID-19 Vaccination in Patients With Gastrointestinal Cancer. In vivo (Athens, Greece). 2024.05; 38 (3): 1278-1284. ( PubMed, DOI )

12. Fujiwara S, Kano Y, Maejima Y, Fujioka T, Tamura K, Kirimura S, Miyake S, Okamoto R. Clinical Response of Primary Malignant Pericardial Mesothelioma with Peritoneal Dissemination to Nivolumab. Internal medicine (Tokyo, Japan). 2023.06; ( PubMed, DOI )

13. Kaneko S, Asahina Y, Nakagawa M, Murakawa M, Miyazaki Y, Asakage T, Fukuda S, Namiki T, Kano Y, Nagata M, Tsuchiya J, Miyoshi M, Kitahata-Kawai F, Nitta S, Itsui Y, Kakinuma S, Okamoto R. Factors associated with liver injury and prognosis in advanced cancer patients treated with immune checkpoint inhibitors. Hepatology research : the official journal of the Japan Society of Hepatology. 2023.01; 53 (5): 450-459. ( PubMed, DOI )

14. Kobayashi Sakurako, Ogasawara Nobuhiko, Watanabe Satoshi, Yoneyama Yosuke, Kirino Sakura, Hiraguri Yui, Inoue Masami, Nagata Sayaka, Okamoto-Uchida Yoshimi, Kofuji Satoshi, Shimizu Hiromichi, Ito Go, Mizutani Tomohiro, Yamauchi Shinichi, Kinugasa Yusuke, Kano Yoshihito, Nemoto Yasuhiro, Watanabe Mamoru, Tsuchiya Kiichiro, Nishina Hiroshi, Okamoto Ryuichi, Yui Shiro. コラーゲンI型を介した機械的シグナル伝達は腸炎時の上皮細胞の運命転換を制御する(Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation) Inflammation and Regeneration. 2022.11; 42 1 of 18-18 of 18. ( 医中誌 )

15. Matsudera Shotaro, Kano Yoshihito, Aoyagi Yasuko, Tohyama Kohki, Ogino Kei, Okamoto Kentaro, Yamaguchi Takeshi, Watanabe Shun, Nakajima Masanobu, Morita Shinji, Nakamura Takatoshi, Suzuki Kan, Tsuchioka Takashi, Kojima Kazuyuki, Miyake Satoshi, Takagi Masatoshi, Ikeda Sadakatsu. A Pilot Study of Comprehensive Genomic Profiling for Pediatric and Adolescent and Young Adult Solid Tumor Patients in Japan(和訳中) Dokkyo Medical Journal. 2022.03; 1 (1): 56-62. ( 医中誌 )

16. Onishi Iichiroh, Kirimura Susumu, Wakejima Ryo, Okubo Kenichi, Odai Tamami, Kakuta Ryota, Kano Yoshihito, Ikeda Sadakatsu, Akashi Takumi, Kitagawa Masanobu. Primary pulmonary choriocarcinoma with a genomic sequence(和訳中) Pathology International. 2022.02; 72 (2): 141-143. ( 医中誌 )

17. Aoyagi Y, Kano Y, Tohyama K, Matsudera S, Kumaki Y, Takahashi K, Mitsumura T, Harada Y, Sato A, Nakamura H, Sueoka E, Aragane N, Kimura K, Onishi I, Takemoto A, Akahoshi K, Ono H, Ishikawa T, Tokunaga M, Nakagawa T, Oshima N, Nakamura R, Takagi M, Asakage T, Uetake H, Tanabe M, Miyake S, Kinugasa Y, Ikeda S. Clinical utility of comprehensive genomic profiling in Japan: Result of PROFILE-F study. PloS one. 2022; 17 (3): e0266112. ( PubMed, DOI )

18. Noji R, Kano Y*(*corresponding author), Hirai H, Onishi I, Nishii N, Yoshimura R, Miyake S, Ikeda S, Harada H. MYC-PDL1 axis reduces sensitivity to nivolumab in recurrent head and neck squamous cell carcinoma. Oral oncology. 2021.12; 124 105666. ( PubMed, DOI )

19. Ikeda Sadakatsu, Kudo Ryo, Yamashita Yamato, Noji Rika, Yokobori Jyunko, Ohki Mika, Takamine Eriko, Kobayashi Yumi, Egawa Makiko, Ebana Yusuke, Kimura Koichiro, Yokoyama Kohta, Onishi Iichiro, Takemoto Akira, Kirimura Susumu, Kinowaki Yuko, Tanimoto Kosuke, Miya Fuyuki, Kano Yoshihito, Yoshida Masayuki, Miyake Satoshi. Clinical utility of multi-disciplinary expert panel discussion in precision cancer medicine ANNALS OF ONCOLOGY. 2021.07; 32 S287. ( DOI )

20. Kano Yoshihito, Gebregiworgis Teklab, Marshall Christopher, Ikura Mitsuhiko, Miyake Satoshi, Ohh Michael. KRAS Q61H mutation evades the regulation of tyrosyl phosphorylation and renders cancer cells resistant to SHP2 inhibitor ANNALS OF ONCOLOGY. 2021.07; 32 S306. ( DOI )