Personnel Information

写真a

KANO Yoshihito


Job title

Project Assistant Professor

Laboratory Address

1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan

Laboratory Phone number

+81-3-5803-4873

Laboratory Fax number

+81-3-5803-0416

Mail Address

The inquiry by e-mail is 《here》

Research Areas, Keywords

Oncology, Cancer gnomic medicine, Targeted therapy
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Graduating School 【 display / non-display 】

  • Tokyo Medical and Dental University, Faculty of Medicine, 2005.03, Graduated

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Graduate School 【 display / non-display 】

  • Tokyo Medical and Dental University, Graduate School, Division of Medical Sciences, Doctor's Course, 2012.03, Completed

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Campus Career 【 display / non-display 】

  • 2012.04
    -
    2014.03
    Tokyo Medical and Dental University， Medical Hospital， Hospital Departments， Department of Internal Medicine， Gastroenterology and Hepatology， Senior Resident
  • 2016.06
    -
    2017.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Systemic Organ Regulation， Gastroenterology and Hepatology， Visiting Lecturer
  • 2019.04
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Comprehensive Patient Care， Clinical Oncology， Project Assistant Professor
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External Career 【 display / non-display 】

  • 2005.04
    -
    2006.03
    , Trainee Resident
  • 2006.04
    -
    2007.03
    , Trainee Resident
  • 2007.04
    -
    2009.03
    , Senior Resident
  • 2014.04
    -
    2019.03
    University of Toronto, Faculty of Medicine, Department of Laboratory Medicine and Pathobiology, Postdoctral Fellow
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Research Areas 【 display / non-display 】

  • Medical genome science

  • Tumor therapeutics

  • Tumor biology

  • Gastroenterology

  • General internal medicine (including psychosomatic medicine)

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Qualification Acquired 【 display / non-display 】

  • Practical English Proficiency Test (1or semi-1 or 2 class)

  • Doctor

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Published Papers & Misc 【 display / non-display 】

  • Matsudera S, Kano Y, Aoyagi Y, Tohyama K, Takahashi K, Kumaki Y, Mitsumura T, Kimura K, Onishi I, Takemoto A, Ban D, Ono H, Kudo A, Oshima N, Ogino K, Watanabe S, Tani Y, Yamaguchi T, Nakajima M, Morita S, Yamaguchi S, Takagi M, Ishikawa T, Nakagawa T, Okamoto K, Uetake H, Tanabe M, Miyake S, Tsuchioka T, Kojima K, Ikeda S. A Pilot Study Analyzing the Clinical Utility of Comprehensive Genomic Profiling Using Plasma Cell-Free DNA for Solid Tumor Patients in Japan (PROFILE Study). Annals of surgical oncology. 2021.03; ( PubMed, DOI )

  • Matsudera S, Kano Y, Ikeda S. ASO Author Reflections: Impact of Liquid Biopsy Using Plasma Cell-Free DNA in Solid Tumors in Japan. Annals of surgical oncology. 2021.03; ( PubMed, DOI )

  • Kano Yoshihito, Marshall Christopher, Ikura Mitsuhiko. Evasion of KRAS Q61H regulation by tyrosine phosphorylation renders cancer cells resistant to SHP2 inhibitors CANCER SCIENCE. 2021.02; 112 171.

  • Liotti F, Kumar N, Prevete N, Marotta M, Sorriento D, Ieranò C, Ronchi A, Marino FZ, Moretti S, Colella R, Puxeddu E, Paladino S, Kano Y, Ohh M, Scala S, Melillo RM. PD-1 blockade delays tumor growth by inhibiting an intrinsic SHP2/Ras/MAPK signalling in thyroid cancer cells. Journal of experimental & clinical cancer research : CR. 2021.01; 40 (1): 22. ( PubMed, DOI )

  • Katsukura N, Watanabe S, Shirasaki T, Hibiya S, Kano Y, Akahoshi K, Tanabe M, Kirimura S, Akashi T, Kitagawa M, Okamoto R, Watanabe M, Tsuchiya K. Intestinal phenotype is maintained by Atoh1 in the cancer region of intraductal papillary mucinous neoplasm. Cancer science. 2020.12; ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  • YOSHIHITO KANO, Teklab Gebregiworgis, Christopher Marshall, Mitsuhiko Ikura, Satoshi Miyake, Michael Ohh. KRAS Q61H mutation evades the regulation of tyrosyl phosphorylation and renders cancer cells resistant to SHP2 inhibitor. 第18回日本臨床腫瘍学会学術集会 2021.02.20

  • 加納 嘉人,野地 理夏, 山下 大和, 工藤 亮, 田崎 彰久, 大野 十央, 有泉 陽介, 平井 秀明, 富岡 寛文, 島本 裕彰, 道 泰之, 三浦 雅彦, 吉村 亮一, 朝蔭 孝宏, 原田 浩之, 岡本 隆一, 三宅 智, 池田 貞勝. Clinical utility of tumor-profiling multiplex gene panel testing in advanced head and neck cancer at TMDU. 第18回日本臨床腫瘍学会学術集会 2021.02.18

  • 加納嘉人、野地理夏、山下大和、工藤亮、大西威一郎、谷本幸介、宮冬樹、中川剛士、石川敏昭、植竹宏之、絹笠祐介、田邉稔、朝蔭孝宏、原田浩之、岡本隆一、三宅智、池田貞勝. Detection of RAS mutation in solid cancers using NGS-based genome profiling tests. 第18回日本臨床腫瘍学会学術集会 2021.02.18

  • Yoshihito Kano, Teklab Gebregiworgis, Christopher B. Marshall, Mitsuhiko Ikura, Michael Ohh. Evasion of KRASQ61H regulation by tyrosine phosphorylation renders cancer cells resistant to SHP2 inhibitor. 第79回日本癌学会学術総会 2020.10.01 Hiroshima

  • Yoshihito Kano, Teklab Gebregiworgis, Christopher Marshall,Mitsuhiko Ikura, Michael Ohh. Inhibition of SHP2 promotes the tyrosyl phosphorylation of KRAS and suppresses the pancreatic cancer growth. 第78回日本癌学会学術集会 2019.09.28 京都

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