Personnel Information

写真a

KANO Yoshihito


Job title

Project Assistant Professor

Laboratory Address

1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan

Laboratory Phone number

+81-3-5803-4873

Laboratory Fax number

+81-3-5803-0416

Mail Address

The inquiry by e-mail is 《here》

Research Areas, Keywords

Oncology, Cancer gnomic medicine, Targeted therapy
To the head of this page.▲

Graduating School 【 display / non-display 】

  • Tokyo Medical and Dental University, Faculty of Medicine, 2005.03, Graduated

To the head of this page.▲

Graduate School 【 display / non-display 】

  • Tokyo Medical and Dental University, Graduate School, Division of Medical Sciences, Doctor's Course, 2012.03, Completed

To the head of this page.▲

Campus Career 【 display / non-display 】

  • 2012.04
    -
    2014.03
    Tokyo Medical and Dental University， Medical Hospital， Hospital Departments， Department of Internal Medicine， Gastroenterology and Hepatology， Senior Resident
  • 2016.06
    -
    2017.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Systemic Organ Regulation， Gastroenterology and Hepatology， Visiting Lecturer
  • 2019.04
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Comprehensive Patient Care， Clinical Oncology， Project Assistant Professor
To the head of this page.▲

External Career 【 display / non-display 】

  • 2005.04
    -
    2006.03
    , Trainee Resident
  • 2006.04
    -
    2007.03
    , Trainee Resident
  • 2007.04
    -
    2009.03
    , Senior Resident
  • 2014.04
    -
    2019.03
    University of Toronto, Faculty of Medicine, Department of Laboratory Medicine and Pathobiology, Postdoctral Fellow
To the head of this page.▲

Research Areas 【 display / non-display 】

  • Molecular biology

  • Medical genome science

  • Tumor therapeutics

  • Tumor biology

  • Gastroenterology

display all >>

To the head of this page.▲

Qualification Acquired 【 display / non-display 】

  • Practical English Proficiency Test (1or semi-1 or 2 class)

  • Doctor

To the head of this page.▲
 

Published Papers & Misc 【 display / non-display 】

  • Valencia-Sama I, Ladumor Y, Kee L, Adderley T, Christopher G, Robinson CM, Kano Y, Ohh M, Irwin MS. NRAS status determines sensitivity to SHP2 inhibitor combination therapies targeting the RAS-MAPK pathway in neuroblastoma. Cancer research. 2020.06; ( PubMed, DOI )

  • 加納 嘉人, Gebregiworgis Teklab, Marshall Christopher, Ikura Mitsuhiko, Ohh Michael. チロシンリン酸化モデルに基づくKRAS変異膵癌に対する治療戦略(Inhibition of SHP2 promotes the tyrosyl phosphorylation of KRAS and suppresses the pancreatic cancer growth) 日本癌学会総会記事. 2019.09; 78回 E-3013. ( ichushi )

  • Robinson CM, Poon BPK, Kano Y, Pluthero FG, Kahr WHA, Ohh M. A hypoxia-inducible HIF1-GAL3ST1-sulfatide axis enhances ccRCC immune evasion via increased tumor cell-platelet binding. Molecular cancer research : MCR. 2019.08; ( PubMed, DOI )

  • Yoshihito Kano, Teklab Gebregiworgis, Christopher B Marshall, Nikolina Radulovich, Betty P K Poon, Jonathan St-Germain, Jonathan D Cook, Ivette Valencia-Sama, Benjamin M M Grant, Silvia Gabriela Herrera, Jinmin Miao, Brian Raught, Meredith S Irwin, Jeffrey E Lee, Jen Jen Yeh, Zhong-Yin Zhang, Ming-Sound Tsao, Mitsuhiko Ikura, Michael Ohh. Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation. Nature Communications. 2019.01; 10 (1): 224. ( PubMed, DOI )

  • Yoshihito Kano, Jonathan D Cook, Jeffrey E Lee, Michael Ohh. New structural and functional insight into the regulation of Ras. Semin. Cell Dev. Biol. 2016.10; 58 70-78. ( PubMed, DOI )

display all >>

To the head of this page.▲

Conference Activities & Talks 【 display / non-display 】

  • Yoshihito Kano, Teklab Gebregiworgis, Christopher Marshall,Mitsuhiko Ikura, Michael Ohh. Inhibition of SHP2 promotes the tyrosyl phosphorylation of KRAS and suppresses the pancreatic cancer growth. 第78回日本癌学会学術集会 2019.09.28 京都

  • 加納嘉人,Teklab Gebregiworgis, Christopher Marshall, 伊倉 光彦, Michael Ohh. KRASチロシンリン酸化モデルに基づく膵癌新規分子機構と治療戦略. 第17回日本臨床腫瘍学会学術集会 2019.07.18

  • Yoshihito Kano, Teklab Gebregiworgis, Christopher B. Marshall, Nikolina Radulovich, Betty P.K. Poon, Zhong-Yin Zhang, Ming-Sound Tsao, Mitsuhiko Ikura and Michael Ohh. TYROSYL PHOSPHORYLATION OF KRAS DISRUPTS THE GTPASE CYCLE AND INHIBITS PANCREATIC CANCER CELL GROWTH.. DDW2018 2018.06.05

  • Teklab Gebregiworgis, Christopher B. Marshall, Yoshihito Kano, Nikolina Radulovich, Ming-Sound Tsao, Michael Ohh, Mitsuhiko Ikura. Altering the regulation of KRAS GTPase cycle via Src and SHP2 creates a potential therapeutic vulnerability for pancreatic cancer. . AACR 2018 2018.04.17

  • Kano Y. Tyrosyl phosphorylation of KRAS disrupts the GTPase cycle and inhibits pancreatic cancer cell growth. Pizza Talk of Department of Biochemistry 2018.03.21 Toronto(Canada)

display all >>

To the head of this page.▲