Personnel Information

写真a

KANO Yoshihito


Job title

Project Assistant Professor

Laboratory Address

1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan

Laboratory Phone number

+81-3-5803-4873

Laboratory Fax number

+81-3-5803-0416

Mail Address

The inquiry by e-mail is 《here

Research Areas, Keywords

Oncology, Cancer gnomic medicine, Targeted therapy

Graduating School 【 display / non-display

  • Tokyo Medical and Dental University, Faculty of Medicine, 2005.03, Graduated

Graduate School 【 display / non-display

  • Tokyo Medical and Dental University, Graduate School, Division of Medical Sciences, Doctor's Course, 2012.03, Completed

Campus Career 【 display / non-display

  • 2012.04
    -
    2014.03
    Tokyo Medical and Dental University, Medical Hospital, Hospital Departments, Department of Internal Medicine, Gastroenterology and Hepatology, Senior Resident
  • 2016.06
    -
    2017.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Gastroenterology and Hepatology, Visiting Lecturer
  • 2019.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Comprehensive Patient Care, Clinical Oncology, Project Assistant Professor

External Career 【 display / non-display

  • 2005.04
    -
    2006.03
    , Trainee Resident
  • 2006.04
    -
    2007.03
    , Trainee Resident
  • 2007.04
    -
    2009.03
    , Senior Resident
  • 2014.04
    -
    2019.03
    University of Toronto, Faculty of Medicine, Department of Laboratory Medicine and Pathobiology, Postdoctral Fellow

Research Areas 【 display / non-display

  • Molecular biology

  • Medical genome science

  • Tumor therapeutics

  • Tumor biology

  • Gastroenterology

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Qualification Acquired 【 display / non-display

  • Practical English Proficiency Test (1or semi-1 or 2 class)

  • Doctor

 

Published Papers & Misc 【 display / non-display

  • Valencia-Sama I, Ladumor Y, Kee L, Adderley T, Christopher G, Robinson CM, Kano Y, Ohh M, Irwin MS. NRAS status determines sensitivity to SHP2 inhibitor combination therapies targeting the RAS-MAPK pathway in neuroblastoma. Cancer research. 2020.06; ( PubMed, DOI )

  • 加納 嘉人, Gebregiworgis Teklab, Marshall Christopher, Ikura Mitsuhiko, Ohh Michael. チロシンリン酸化モデルに基づくKRAS変異膵癌に対する治療戦略(Inhibition of SHP2 promotes the tyrosyl phosphorylation of KRAS and suppresses the pancreatic cancer growth) 日本癌学会総会記事. 2019.09; 78回 E-3013. ( ichushi )

  • Robinson CM, Poon BPK, Kano Y, Pluthero FG, Kahr WHA, Ohh M. A hypoxia-inducible HIF1-GAL3ST1-sulfatide axis enhances ccRCC immune evasion via increased tumor cell-platelet binding. Molecular cancer research : MCR. 2019.08; ( PubMed, DOI )

  • Yoshihito Kano, Teklab Gebregiworgis, Christopher B Marshall, Nikolina Radulovich, Betty P K Poon, Jonathan St-Germain, Jonathan D Cook, Ivette Valencia-Sama, Benjamin M M Grant, Silvia Gabriela Herrera, Jinmin Miao, Brian Raught, Meredith S Irwin, Jeffrey E Lee, Jen Jen Yeh, Zhong-Yin Zhang, Ming-Sound Tsao, Mitsuhiko Ikura, Michael Ohh. Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation. Nature Communications. 2019.01; 10 (1): 224. ( PubMed, DOI )

  • Yoshihito Kano, Jonathan D Cook, Jeffrey E Lee, Michael Ohh. New structural and functional insight into the regulation of Ras. Semin. Cell Dev. Biol. 2016.10; 58 70-78. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  • Yoshihito Kano, Teklab Gebregiworgis, Christopher Marshall,Mitsuhiko Ikura, Michael Ohh. Inhibition of SHP2 promotes the tyrosyl phosphorylation of KRAS and suppresses the pancreatic cancer growth. 第78回日本癌学会学術集会 2019.09.28 京都

  • 加納嘉人,Teklab Gebregiworgis, Christopher Marshall, 伊倉 光彦, Michael Ohh. KRASチロシンリン酸化モデルに基づく膵癌新規分子機構と治療戦略. 第17回日本臨床腫瘍学会学術集会 2019.07.18

  • Yoshihito Kano, Teklab Gebregiworgis, Christopher B. Marshall, Nikolina Radulovich, Betty P.K. Poon, Zhong-Yin Zhang, Ming-Sound Tsao, Mitsuhiko Ikura and Michael Ohh. TYROSYL PHOSPHORYLATION OF KRAS DISRUPTS THE GTPASE CYCLE AND INHIBITS PANCREATIC CANCER CELL GROWTH.. DDW2018 2018.06.05

  • Teklab Gebregiworgis, Christopher B. Marshall, Yoshihito Kano, Nikolina Radulovich, Ming-Sound Tsao, Michael Ohh, Mitsuhiko Ikura. Altering the regulation of KRAS GTPase cycle via Src and SHP2 creates a potential therapeutic vulnerability for pancreatic cancer. . AACR 2018 2018.04.17

  • Kano Y. Tyrosyl phosphorylation of KRAS disrupts the GTPase cycle and inhibits pancreatic cancer cell growth. Pizza Talk of Department of Biochemistry 2018.03.21 Toronto(Canada)

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