Personnel Information

写真a

KUWAHARA Hiroya


Job title

Junior Associate Professor

Laboratory Address

Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan

Laboratory Phone number

+81-3-5803-5234

Laboratory Fax number

+81-3-5803-0169

Mail Address

h-kuwahara.nuro@tmd.ac.jp

Research Areas, Keywords

Neurology, Nucleic acid medicine, Drug delivery

Graduating School 【 display / non-display

  • Tokyo Medical and Dental University, Faculty of Medicine, 2002.03, Graduated

Graduate School 【 display / non-display

  • Tokyo Medical and Dental University, Doctor's Course, 2011.03, Completed

Campus Career 【 display / non-display

  • 2004.04
    -
    2005.05
    Tokyo Medical and Dental University, Medical Hospital, Hospital Departments, Department of Neurology, Neurosurgery,Psychiatry and Anesthesiology, Neurology, Senior Resident
  • 2007.04
    -
    2011.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Cognitive and Behavioral Medicine, Neurology and Neurological Science, Graduate Student
  • 2007.06
    -
    2008.03
    Tokyo Medical and Dental University, Medical Hospital, Hospital Departments, Department of Neurology, Neurosurgery,Psychiatry and Anesthesiology, Neurology, Senior Resident
  • 2011.04
    -
    2011.05
    Tokyo Medical and Dental University, Medical Hospital, Hospital Departments, Department of Neurology, Neurosurgery,Psychiatry and Anesthesiology, Neurology, Senior Resident
  • 2013.04
    -
    2018.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Cognitive and Behavioral Medicine, Neurology and Neurological Science, Project Assistant Professor

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External Career 【 display / non-display

  • 2002.04
    -
    2004.03
    , Trainee Resident

Academic Society Affiliations 【 display / non-display

  • American Society of Gene and Cell Therapy

  • Oligonucleotide Therapeutics Society

Research Areas 【 display / non-display

  • Neurology

Qualification Acquired 【 display / non-display

  • Doctor

 

Published Papers & Misc 【 display / non-display

  • Su Su Lei Mon, Kotaro Yoshioka, Chunyan Jia, Taiki Kunieda, Yutaro Asami, Kie Yoshida-Tanaka, Wenying Piao, Hiroya Kuwahara, Kazutaka Nishina, Tetsuya Nagata, Takanori Yokota. Highly efficient gene silencing in mouse brain by overhanging-duplex oligonucleotides via intraventricular route. FEBS Lett. 2020.05; 594 (9): 1413-1423. ( PubMed, DOI )

  • Masaki Ohyagi, Takashi Irioka, Takuya Ohkubo, Satoru Ishibashi, Yuko K Takahashi, Eiichiro Amano, Akira Machida, Hiroya Kuwahara, Takanori Yokota. Intrathecal IgG Synthesis and Persistent Inflammation Are Associated with White Matter Lesions in HIV-negative Patients with Cryptococcal Meningoencephalitis. Intern Med. 2019.11; 58 (21): 3077-3082. ( PubMed, DOI )

  • Kotaro Yoshioka, Taiki Kunieda, Yutaro Asami, Huijia Guo, Haruka Miyata, Kie Yoshida-Tanaka, Yumiko Sujino, Wenying Piao, Hiroya Kuwahara, Kazutaka Nishina, Rintaro Iwata Hara, Tetsuya Nagata, Takeshi Wada, Satoshi Obika, Takanori Yokota. Highly efficient silencing of microRNA by heteroduplex oligonucleotides. Nucleic Acids Res. 2019.08; 47 (14): 7321-7332. ( PubMed, DOI )

  • Satoshi Zeniya, Hiroya Kuwahara, Kaiichi Daizo, Akihiro Watari, Masuo Kondoh, Kie Yoshida-Tanaka, Hidetoshi Kaburagi, Ken Asada, Tetsuya Nagata, Masahiro Nagahama, Kiyohito Yagi, Takanori Yokota. Angubindin-1 opens the blood-brain barrier in vivo for delivery of antisense oligonucleotide to the central nervous system. J Control Release. 2018.05; 283 126-134. ( PubMed, DOI )

  • Hiroya Kuwahara, Jindong Song, Takahiro Shimoura, Kie Yoshida-Tanaka, Tadahaya Mizuno, Tatsuki Mochizuki, Satoshi Zeniya, Fuying Li, Kazutaka Nishina, Tetsuya Nagata, Shingo Ito, Hiroyuki Kusuhara, Takanori Yokota. Modulation of blood-brain barrier function by a heteroduplex oligonucleotide in vivo. Sci Rep. 2018.03; 8 (1): 4377. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  • Hiroya Kuwahara, Jindong Song, Takahiro Shimoura, Kie Yoshida-Tanaka, Tadahaya Mizuno, Tatsuki Mochizuki, Kazutaka Nishina, Tetsuya Nagata, Hiroyuki Kusuhara, Takanori Yokota.. Modulation of blood-brain barrier function by heteroduplex oligonucleotide in vivo.. The 40th Annual Meeting of the Japan Neuroscience Society 2017.07.22 Chiba

  • Hiroya Kuwahara, Yasutaka Anraku, Kazunori Kataoka, Takanori Yokota. Investigation of delivery mechanism of BBB-crossing nanomachine. 3rd COINS International Symposium 2016.12.15 Kawasaki

  • Hiroya Kuwahara, Takahiro Shimoura, Jindong Song, Kie Yoshida-Tanaka, Tadahaya Mizuno, Tatsuki Mochizuki, Kazutaka Nishina, Tetsuya Nagata, Hiroyuki Kusuhara, Takanori Yokota. Novel oligonucleotide to regulate the blood-brain barrier. 3rd International Conference on Biomaterials Science 2016.11.28 Tokyo

  • Hiroya Kuwahara, Takahiro Shimoura, Jindong Song, Kie Yoshida-Tanaka, Tadahaya Mizuno, Tatsuki Mochizuki, Masaki Ohyagi, Kazutaka Nishina, Tetsuya Nagata, Hiroyuki Kusuhara, Takanori Yokota. New platform technology to regulate the blood-brain barrier function in vivo. 19th International Symposium on Signal Transduction at the Blood-Brain Barriers 2016.09.15 Copenhagen

  • Hiroya Kuwahara. Development of nucleic acid therapeutics to target the blood-brain barrier. The 22nd Symposium of Forum for Pharmaceutical Technology Innovation 2016.09.09 Tokyo

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Patents 【 display / non-display

  • CARRIER FOR USE IN DELIVERING DRUG, CONJUGATE, COMPOSITION COMPRISING SAME, AND METHOD FOR ADMINISTRATING SAME

    Patent Number: 9,937,263

  • CARRIER FOR USE IN DELIVERING DRUG, CONJUGATE, COMPOSITION COMPRISING SAME, AND METHOD FOR ADMINISTRATING SAME

    Patent Number: 201480063806.3