Personnel Information

写真a

KUWAHARA Hiroya


Job title

Junior Associate Professor

Laboratory Address

Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan

Laboratory Phone number

+81-3-5803-5234

Laboratory Fax number

+81-3-5803-0169

Mail Address

h-kuwahara.nuro@tmd.ac.jp

Homepage URL

https://www.tmd.ac.jp/med/nuro/index-e.html

Research Areas, Keywords

Neurology, Nucleic acid medicine, Drug delivery
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Graduating School 【 display / non-display 】

  • Tokyo Medical and Dental University, Faculty of Medicine, 2002.03, Graduated

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Graduate School 【 display / non-display 】

  • Tokyo Medical and Dental University, Doctor's Course, 2011.03, Completed

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Campus Career 【 display / non-display 】

  • 2004.04
    -
    2005.05
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Neurology, Neurosurgery,Psychiatry and Anesthesiology， Neurology， Senior Resident
  • 2007.04
    -
    2011.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Neurology and Neurological Science， Graduate Student
  • 2007.06
    -
    2008.03
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Neurology, Neurosurgery,Psychiatry and Anesthesiology， Neurology， Senior Resident
  • 2011.04
    -
    2011.05
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Neurology, Neurosurgery,Psychiatry and Anesthesiology， Neurology， Senior Resident
  • 2013.04
    -
    2018.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Neurology and Neurological Science， Project Assistant Professor
  • 2018.05
    -
    2019.04
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Division of Cognitive and Behavioral Medicine， Department of Neurology and Neurological Science， Visiting Lecturer
  • 2019.05
    -
    2020.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Division of Cognitive and Behavioral Medicine， Department of Neurology and Neurological Science， Visiting Lecturer
  • 2020.04
    -
    2020.07
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Neurology, Neurosurgery,Psychiatry and Anesthesiology， Neurology， Assistant Professor
  • 2020.08
    -
    2021.04
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Neurology and Neurological Science， Junior Associate Professor
  • 2021.05
    　
    　
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Neurology, Neurosurgery,Psychiatry and Anesthesiology， Neurology， Junior Associate Professor
  • 2021.06
    -
    2021.09
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Neurology, Neurosurgery,Psychiatry and Anesthesiology， Neurology， Junior Associate Professor
  • 2021.10
    -
    2022.03
    Tokyo Medical and Dental University， Tokyo Medical and Dental University， Division of Clinical Medicine， Department of Neurology, Neurosurgery, Psychiatry, and Anesthesiology， Neurology， Junior Associate Professor
  • 2022.04
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Neurology and Neurological Science， Junior Associate Professor

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External Career 【 display / non-display 】

  • 2002.04
    -
    2004.03
    , Trainee Resident
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Academic Society Affiliations 【 display / non-display 】

  • American Society of Gene and Cell Therapy

  • Oligonucleotide Therapeutics Society

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Research Areas 【 display / non-display 】

  • Neurology

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Qualification Acquired 【 display / non-display 】

  • Doctor

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Published Papers & Misc 【 display / non-display 】

  1. Su Su Lei Mon, Kotaro Yoshioka, Chunyan Jia, Taiki Kunieda, Yutaro Asami, Kie Yoshida-Tanaka, Wenying Piao, Hiroya Kuwahara, Kazutaka Nishina, Tetsuya Nagata, Takanori Yokota. Highly efficient gene silencing in mouse brain by overhanging-duplex oligonucleotides via intraventricular route. FEBS Lett. 2020.05; 594 (9): 1413-1423. ( PubMed, DOI )

  2. Masaki Ohyagi, Takashi Irioka, Takuya Ohkubo, Satoru Ishibashi, Yuko K Takahashi, Eiichiro Amano, Akira Machida, Hiroya Kuwahara, Takanori Yokota. Intrathecal IgG Synthesis and Persistent Inflammation Are Associated with White Matter Lesions in HIV-negative Patients with Cryptococcal Meningoencephalitis. Intern Med. 2019.11; 58 (21): 3077-3082. ( PubMed, DOI )

  3. Kotaro Yoshioka, Taiki Kunieda, Yutaro Asami, Huijia Guo, Haruka Miyata, Kie Yoshida-Tanaka, Yumiko Sujino, Wenying Piao, Hiroya Kuwahara, Kazutaka Nishina, Rintaro Iwata Hara, Tetsuya Nagata, Takeshi Wada, Satoshi Obika, Takanori Yokota. Highly efficient silencing of microRNA by heteroduplex oligonucleotides. Nucleic Acids Res. 2019.08; 47 (14): 7321-7332. ( PubMed, DOI )

  4. Satoshi Zeniya, Hiroya Kuwahara, Kaiichi Daizo, Akihiro Watari, Masuo Kondoh, Kie Yoshida-Tanaka, Hidetoshi Kaburagi, Ken Asada, Tetsuya Nagata, Masahiro Nagahama, Kiyohito Yagi, Takanori Yokota. Angubindin-1 opens the blood-brain barrier in vivo for delivery of antisense oligonucleotide to the central nervous system. J Control Release. 2018.05; 283 126-134. ( PubMed, DOI )

  5. Hiroya Kuwahara, Jindong Song, Takahiro Shimoura, Kie Yoshida-Tanaka, Tadahaya Mizuno, Tatsuki Mochizuki, Satoshi Zeniya, Fuying Li, Kazutaka Nishina, Tetsuya Nagata, Shingo Ito, Hiroyuki Kusuhara, Takanori Yokota. Modulation of blood-brain barrier function by a heteroduplex oligonucleotide in vivo. Sci Rep. 2018.03; 8 (1): 4377. ( PubMed, DOI )

  6. Y Anraku, H Kuwahara, Y Fukusato, A Mizoguchi, T Ishii, K Nitta, Y Matsumoto, K Toh, K Miyata, S Uchida, K Nishina, K Osada, K Itaka, N Nishiyama, H Mizusawa, T Yamasoba, T Yokota, K Kataoka. Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain. Nat Commun. 2017.10; 8 (1): 1001. ( PubMed, DOI )

  7. Koya Ono, Ken Murata, Toshinari Arai, Tomoyuki Kino, Keisuke Onaka, Satoru Takahashi, Hirotaka Sato, Hiroya Kuwahara. Posterior reversible encephalopathy syndrome after iron administration in a patient with chronic severe anemia. Journal of the Neurological Sciences. 2016.08; 367 333-334. ( PubMed, DOI )

  8. Masahiro Murakami, Kazutaka Nishina, Chie Watanabe, Kie Yoshida-Tanaka, Wenying Piao, Hiroya Kuwahara, Yuji Horikiri, Kanjiro Miyata, Nobuhiro Nishiyama, Kazunori Kataoka, Masayuki Yoshida, Hidehiro Mizusawa, Takanori Yokota.. Enteral siRNA delivery technique for therapeutic gene silencing in the liver via the lymphatic route. Scientific Reports. 2015.11; 5 17035. ( PubMed, DOI )

  9. Kazutaka Nishina, Wenying Piao, Kie Yoshida-Tanaka, Yumiko Sujino, Tomoko Nishina, Tsuyoshi Yamamoto, Keiko Nitta, Kotaro Yoshioka, Hiroya Kuwahara, Hidenori Yasuhara, Takeshi Baba, Fumiko Ono, Kanjiro Miyata, Koichi Miyake, Punit P Seth, Audrey Low, Masayuki Yoshida, C Frank Bennett, Kazunori Kataoka, Hidehiro Mizusawa, Satoshi Obika, Takanori Yokota.. DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing. Nature Communications.. 2015.08; 6 7969. ( PubMed, DOI )

  10. Hiroya Kuwahara, Kazutaka Nishina, Takanori Yokota.. Blood-brain barrier: a novel therapeutic target in multiple sclerosis. Clinical and Experimental Neuroimmunology.. 2015.05; 6 (2): 129-138. ( DOI )

  11. Tomoko Nishina, Junna Numata, Kazutaka Nishina, Kie Yoshida-Tanaka, Keiko Nitta, Wenying Piao, Rintaro Iwata, Shingo Ito, Hiroya Kuwahara, Takeshi Wada, Hidehiro Mizusawa, Takanori Yokota.. Chimeric Antisense Oligonucleotide Conjugated to α-Tocopherol. Mol Ther Nucleic Acids.. 2015.01; 4 e220. ( PubMed, DOI )

  12. Kuwahara Hiroya, Tsuchiya Kuniaki, Kobayashi Zen, Inaba Akira, Akiyama Haruhiko, Mizusawa Hidehiro.. Cryptococcal meningitis accompanying lymphocytic inflammation predominantly in cerebral deep white matter: a possible manifestation of immune reconstitution inflammatory syndrome. Neuropathology.. 2014.02; 34 (1): 45-48. ( PubMed, DOI )

  13. Hirai Takashi, Enomoto Mitsuhiro, Kaburagi Hidetoshi, Sotome Shinichi, Yoshida-Tanaka Kie, Ukegawa Madoka, Kuwahara Hiroya, Yamamoto Mariko, Tajiri Mio, Miyata Haruka, Hirai Yukihiko, Tominaga Makoto, Shinomiya Kenichi, Mizusawa Hidehiro, Okawa Atsushi, Yokota Takanori.. Intrathecal AAV serotype 9-mediated delivery of shRNA against TRPV1 attenuates thermal hyperalgesia in a mouse model of peripheral nerve injury. Molecular Therapy.. 2014.02; 22 (2): 409-419. ( PubMed, DOI )

  14. Kuwahara Hiroya, Suzuki Shigeharu, Matsumura Ken, Watanabe Mutsufusa, Yakushiji Fumiatsu, Fujigasaki Hiroto.. Ocular flutter, generalized myoclonus, and truncal ataxia in a patient with Graves' ophthalmopathy. Journal of Neurology.. 2013.11; 260 (11): 2906-2907. ( PubMed, DOI )

  15. Machida Akira, Kuwahara Hiroya, Mayra Azat, Kubodera Takayuki, Hirai Takashi, Sunaga Fumiko, Tajiri Mio, Hirai Yukihiko, Shimada Takashi, Mizusawa Hidehiro, Yokota Takanori.. Intraperitoneal administration of AAV9-shRNA inhibits target gene expression in the dorsal root ganglia of neonatal mice. Molecular Pain.. 2013.07; 9 36. ( PubMed, DOI )

  16. Hiroya Kuwahara.. Persistent hemichorea. New England Journal of Medicine. 2013.05; 368 (20): e26. ( PubMed, DOI )

  17. Piao Wenying, Nishina Kazutaka, Yoshida-Tanaka Kie, Kuwahara Hiroya, Nishina Tomoko, Sakata Mina, Mizusawa Hidehiro, Yokota Takanori. Efficient in vivo delivery of antisense oligonucleotide to choroid plexus. J Med Dent Sci. 2013.03; 60 (1): 9-16. ( PubMed )

  18. Kuwahara Hiroya, Matsumura Ken, Watanabe Mutsufusa, Fujigasaki Hiroto. Intravenous t-PA for the occlusion of an accessory MCA. Intern Med. 2013.01; 52 (1): 163. ( PubMed )

  19. Hirai Takashi, Enomoto Mitsuhiro, Machida Akira, Yamamoto Mariko, Kuwahara Hiroya, Tajiri Mio, Hirai Yukihiko, Sotome Shinichi, Mizusawa Hidehiro, Shinomiya Kenichi, Okawa Atsushi, Yokota Takanori. Intrathecal shRNA-AAV9 inhibits target protein expression in the spinal cord and dorsal root ganglia of adult mice. Hum Gene Ther Methods. 2012.04; 23 (2): 119-127. ( PubMed, DOI )

  20. Kuwahara Hiroya, Yokota Takanori. Delivery of siRNA into the blood-brain barrier: recent advances and future perspective. Ther Deliv. 2012.04; 3 (4): 417-420. ( PubMed )

  21. Kuwahara Hiroya, Matsunaga Shin-ichi. Central pontine myelinolysis associated with pancreatic diabetes. J Neurol. 2012.02; 259 (2): 353-354. ( PubMed, DOI )

  22. Kuwahara Hiroya, Nishina Kazutaka, Yoshida Kie, Nishina Tomoko, Yamamoto Mariko, Saito Yukari, Piao Wenying, Yoshida Masayuki, Mizusawa Hidehiro, Yokota Takanori. Efficient in vivo delivery of siRNA into brain capillary endothelial cells along with endogenous lipoprotein. Mol Ther. 2011.12; 19 (12): 2213-2221. ( PubMed, DOI )

  23. Kuwahara Hiroya, Nakatsuru Enichi, Ozawa Naoko. Exertional rhabdomyolysis affecting anterior compartment of unilateral lower leg. Intern Med. 2011.04; 50 (7): 793. ( PubMed )

  24. Kuwahara Hiroya, Noguchi Yoshimasa, Saito Yukinobu, Inaba Akira. Multiple cavernous angiomas in the brain and spinal cord. Arch Neurol. 2010.11; 67 (11): 1405-1406. ( PubMed, DOI )

  25. Kuwahara Hiroya, Tsuchiya Kuniaki, Saito Yukinobu, Kobayashi Zen, Miyazaki Hiroshi, Izumiyama Yoko, Akiyama Haruhiko, Arai Tetsuaki, Mizusawa Hidehiro. Frontotemporal lobar degeneration with motor neuron disease showing severe and circumscribed atrophy of anterior temporal lobes. J Neurol Sci. 2010.10; 297 (1-2): 92-96. ( PubMed, DOI )

  26. Koyama Rikako, Nakanishi Koji, Kato Masako, Yamashita Shigeo, Kuwahara Hiroya, Katori Hideyuki. Hypoglycemia and hyperglycemia due to insulin antibodies against therapeutic human insulin: treatment with double filtration plasmapheresis and prednisolone. Am J Med Sci. 2005.05; 329 (5): 259-264. ( PubMed )

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Conference Activities & Talks 【 display / non-display 】

  1. Hiroya Kuwahara, Jindong Song, Takahiro Shimoura, Kie Yoshida-Tanaka, Tadahaya Mizuno, Tatsuki Mochizuki, Kazutaka Nishina, Tetsuya Nagata, Hiroyuki Kusuhara, Takanori Yokota.. Modulation of blood-brain barrier function by heteroduplex oligonucleotide in vivo.. The 40th Annual Meeting of the Japan Neuroscience Society 2017.07.22 Chiba

  2. Hiroya Kuwahara, Yasutaka Anraku, Kazunori Kataoka, Takanori Yokota. Investigation of delivery mechanism of BBB-crossing nanomachine. 3rd COINS International Symposium 2016.12.15 Kawasaki

  3. Hiroya Kuwahara, Takahiro Shimoura, Jindong Song, Kie Yoshida-Tanaka, Tadahaya Mizuno, Tatsuki Mochizuki, Kazutaka Nishina, Tetsuya Nagata, Hiroyuki Kusuhara, Takanori Yokota. Novel oligonucleotide to regulate the blood-brain barrier. 3rd International Conference on Biomaterials Science 2016.11.28 Tokyo

  4. Hiroya Kuwahara, Takahiro Shimoura, Jindong Song, Kie Yoshida-Tanaka, Tadahaya Mizuno, Tatsuki Mochizuki, Masaki Ohyagi, Kazutaka Nishina, Tetsuya Nagata, Hiroyuki Kusuhara, Takanori Yokota. New platform technology to regulate the blood-brain barrier function in vivo. 19th International Symposium on Signal Transduction at the Blood-Brain Barriers 2016.09.15 Copenhagen

  5. Hiroya Kuwahara, Takahiro Shimoura, Jindong Song, Kie Yoshida-Tanaka, Kazutaka Nishina, Tetsuya Nagata, Takanori Yokota. A novel platform technology to regulate the blood-brain barrier in vivo. 57th Annual Meeting of the Japanese Society of Neurology 2016.05.19 Kobe

  6. Hiroya Kuwahara, Takahiro Shimoura, Jindong Song, Kie Yoshida-Tanaka, Kazutaka Nishina, Tetsuya Nagata, Takanori Yokota. Hetero-duplex oligonucleotide to regulate the blood-brain barrier function in vivo. Oligonucleotide Therapeutics & Delivery 2016.04.04 Boston

  7. Hiroya Kuwahara, Takahiro Shimoura, Jingdong Song, Kie Yoshida-Tanaka, Kazutaka Nishina, Tetsuya Nagata, Takanori Yokota. A new therapeutic oligonucleotide to regulate the blood-brain barrier in vivo. Barcelona BioMed Conferences on the Blood-Brain Barrier 2015.11.02 Barcelona

  8. Hiroya Kuwahara, Takahiro Shimoura, Jingdong Song, Kie Yoshida-Tanaka, Kazutaka Nishina, Tetsuya Nagata, Takanori Yokota. A new therapeutic oligonucleotide to regulate the blood-brain barrier. 11th Annual Meeting of the Oligonucleotide Therapeutics Society 2015.10.14 Leiden

  9. Hiroya Kuwahara, Takahiro Shimoura, Jingdong Song, Kie Yoshida-Tanaka, Kazutaka Nishina, Tetsuya Nagata, Takanori Yokota. A new platform technology to regulate the blood-brain barrier for molecular targeted therapy of multiple sclerosis. The Inaugural Asia-Pacific School of Neuroimmunology 2015.08.30 Tokyo

  10. Hiroya Kuwahara, Kazutaka Nishina, Wenying Piao, Takanori Yokota. Development of nanomachine that delivers therapeutic oligonucleotide across the blood-brain barrier into brain. 1st COINS International Symposium 2015.02.27 Tokyo

  11. Hiroya Kuwahara, Takanori Yokota. Development of BBB-targeting nucleic acid medicine. The 37th Annual Meeting of the Japan Neuroscience Society 2014.09.13 Yokohama

  12. Hiroya Kuwahara, Kazutaka Nishina, Kie Yoshida-Tanaka, Tomoko Nishina, Wenying Piao, Hidehiro Mizusawa, Takanori Yokota. Efficient in vivo delivery of siRNA into brain capillary endothelial cells along with endogenous lipoprotein. 10th International Conference on Cerebral Vascular Biology 2013.06.19 Montreal

  13. Hiroya Kuwahara, Hiroshi Fujita, Ken Matsumura, Mutsufusa Watanabe, Junji Tomiyama, Hiroto Fujigasaki. Cerebrovascular disorders in myeloproliferative neoplasms with the JAK2 V617F mutation. The 2nd International Congress on Neurology and Epidemiology 2012.11.08 Nice

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Patents 【 display / non-display 】

  • CARRIER FOR USE IN DELIVERING DRUG, CONJUGATE, COMPOSITION COMPRISING SAME, AND METHOD FOR ADMINISTRATING SAME

    Patent Number： US10912838

  • CARRIER FOR USE IN DELIVERING DRUG, CONJUGATE, COMPOSITION COMPRISING SAME, AND METHOD FOR ADMINISTRATING SAME

    Patent Number： EP 3072506

  • CARRIER FOR USE IN DELIVERING DRUG, CONJUGATE, COMPOSITION COMPRISING SAME, AND METHOD FOR ADMINISTRATING SAME

    Patent Number： US 9,937,263

  • CARRIER FOR USE IN DELIVERING DRUG, CONJUGATE, COMPOSITION COMPRISING SAME, AND METHOD FOR ADMINISTRATING SAME

    Patent Number： 201480063806.3

  • CARRIER FOR USE IN DELIVERING DRUG, CONJUGATE, COMPOSITION COMPRISING SAME, AND METHOD FOR ADMINISTRATING SAME

    Patent Number： 2931056

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