Personnel Information

写真a

TSUJI-HOSOKAWA Atsumi


Job title

Project Assistant Professor
To the head of this page.▲

Graduate School 【 display / non-display 】

  • Tokyo Medical and Dental University, Graduate School, Division of Medicine, Doctor's Course, 2018.03, Completed

To the head of this page.▲

Campus Career 【 display / non-display 】

  • 2014.04
    -
    2018.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Environmental Response， Pediatrics and Developmental Biology， Graduate Student
  • 2023.05
    -
    2024.09
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Division of Bio-Environmental Response， Department of Pediatrics and Developmental Biology， Visiting Lecturer
  • 2024.10
    -
    2025.01
    Institute of Science Tokyo， Visiting Lecturer
  • 2025.02
    -
    Now
    Institute of Science Tokyo， -， Institute of Science Tokyo Hospital， Division of Clinical Management， Professional Development Center， Project Assistant Professor
To the head of this page.▲

External Career 【 display / non-display 】

  • 2017.10
    -
    2019.01
    Univeristy of Arizona, Department of Physiology, Research Specialist
To the head of this page.▲

Qualification Acquired 【 display / non-display 】

  • Doctor

To the head of this page.▲
 

Published Papers & Misc 【 display / non-display 】

  1. Haruki Yamano, Kazuhiro Watanabe, Minami Komatsu, Atsuko Hashimoto, Yuri Suzuki, Shizuka Kirino, Yoko Saito, Eriko Adachi, Gau Maki, Hisae Nakatani, Atsumi Hosokawa-Tsuji, Kenichi Kashimada, Nobuyuki Ishige, Kei Takasawa. Enhancing Accuracy of Newborn Screening for 21OHD: Strategic Use of 21-Deoxycortisol in a Large-Scale Tokyo Cohort. J Clin Endocrinol Metab. 2025.09; ( PubMed, DOI )

  2. Toshiyuki Ko, Daigo Nishijo, Atsumi Tsuji-Hosokawa, Iku Tsuchiya, Seitaro Nomura, Bo Zhang, Yue Jiang, Kaho Fujimori, Takashi Hiruma, Ryo Abe, Takahiro Jimba, Shunsuke Inoue, Zhehao Dai, Manami Katoh, Mikako Katagiri, Masamichi Ito, Hiroyuki Morita, Shuji Takada, Norihiko Takeda, Akihiro Umezawa, Issei Komuro. Correction of the Murine Model of Congenital Heart Disease Associated With the Nkx2-5 Mutation Using Prime Editing Circ Genom Precis Med. 2025.08; 18 (4): e005194. ( PubMed, DOI )

  3. Yuya Ogawa, Iku Tsuchiya, Shogo Yanai, Takashi Baba, Ken-Ichirou Morohashi, Takehiko Sasaki, Junko Sasaki, Miho Terao, Atsumi Tsuji-Hosokawa, Shuji Takada. Author Correction: GATA4 binding to the Sox9 enhancer mXYSRa/Enh13 is critical for testis differentiation in mouse. Commun Biol. 2025.02; 8 (1): 199. ( PubMed, DOI )

  4. Tsuji-Hosokawa, A; Tsuchiya, I; Shimizu, K; Terao, M; Yasuhara, M; Miyamoto, N; Kikuchi, S; Ogawa, Y; Nakamura, K; Matsubara, Y; Takada, S. Genetically humanized phenylketonuria mouse model as a testing tool for human genome editing in fertilized eggs JOURNAL OF INHERITED METABOLIC DISEASE. 2025.01; 48 (1): e12803. ( PubMed, DOI )

  5. Adachi E, Nakagawa R, Tsuji-Hosokawa A, Gau M, Kirino S, Yogi A, Nakatani H, Takasawa K, Yamaguchi T, Kosho T, Murakami M, Tajima T, Hasegawa T, Yamada T, Morio T, Ohara O, Kashimada K. A MinION-based Long-Read Sequencing Application With One-Step PCR for the Genetic Diagnosis of 21-Hydroxylase Deficiency. The Journal of clinical endocrinology and metabolism. 2024.02; 109 (3): 750-760. ( PubMed, DOI )

  6. Ogawa, Y; Terao, M; Tsuji-Hosokawa, A; Tsuchiya, I; Hasegawa, M; Takada, S. SOX9 and SRY binding sites on mouse mXYSRa/Enh13 enhancer redundantly regulate Sox9 expression to varying degrees HUMAN MOLECULAR GENETICS. 2023.01; 32 (1): 55-64. ( PubMed, DOI )

  7. Takizawa C, Nakatani H, Saito Y, Tsuji-Hosokawa A, Kikuchi E, Shimoda M, Takasawa K. A hypercalcemic episode in an adolescent with autosomal dominant hypocalcemia. Pediatrics international : official journal of the Japan Pediatric Society. 2023.01; 65 (1): e15707. ( PubMed, DOI )

  8. Takizawa Chieko, Nakatani Hisae, Saito Yoko, Tsuji-Hosokawa Atsumi, Kikuchi Eriko, Shimoda Masuhiro, Takasawa Kei. 高カルシウム血症エピソードが出現した常染色体顕性低カルシウム血症の1例(A hypercalcemic episode in an adolescent with autosomal dominant hypocalcemia) Pediatrics International. 2023; 65 (1): ped.15707. ( ichushi )

  9. Watanabe K, Tsuji-Hosokawa A, Hashimoto A, Konishi K, Ishige N, Yajima H, Sutani A, Nakatani H, Gau M, Takasawa K, Tajima T, Hasegawa T, Morio T, Kashimada K. The High Relevance of 21-Deoxycortisol, (Androstenedione + 17α-Hydroxyprogesterone)/Cortisol, and 11-Deoxycortisol/17α-Hydroxyprogesterone for Newborn Screening of 21-Hydroxylase Deficiency. The Journal of clinical endocrinology and metabolism. 2022.11; 107 (12): 3341-3352. ( PubMed, DOI )

  10. Nakagawa R, Takasawa K, Gau M, Tsuji-Hosokawa A, Kawaji H, Murakawa Y, Takada S, Mikami M, Narumi S, Fukami M, Sreenivasan R, Maruyama T, Tucker EJ, Zhao L, Bowles J, Sinclair A, Koopman P, Hayashizaki Y, Morio T, Kashimada K. Two ovarian candidate enhancers, identified by time series enhancer RNA analyses, harbor rare genetic variations identified in ovarian insufficiency. Human molecular genetics. 2022.07; 31 (13): 2223-2235. ( PubMed, DOI )

  11. Tsuji-Hosokawa, A; Ogawa, Y; Tsuchiya, I; Terao, M; Takada, S. Human <i>SRY</i> Expression at the Sex-determining Period is Insufficient to Drive Testis Development in Mice ENDOCRINOLOGY. 2022.01; 163 (1): ( PubMed, DOI )

  12. Rui Si, Jody Tori O Cabrera, Atsumi Tsuji-Hosokawa, Rui Guo, Makiko Watanabe, Lei Gao, Yun Sok Lee, Jae-Su Moon, Brian T Scott, Jian Wang, Anthony W Ashton, Jaladanki N Rao, Jian-Ying Wang, Jason X-J Yuan, Ayako Makino. HuR/Cx40 downregulation causes coronary microvascular dysfunction in type 2 diabetes. JCI Insight. 2021.11; 6 (21): ( PubMed, DOI )

  13. Tsuji-Hosokawa A, Kashimada K. Thirty-Year Lessons from the Newborn Screening for Congenital Adrenal Hyperplasia (CAH) in Japan. International journal of neonatal screening. 2021.06; 7 (3): ( PubMed, DOI )

  14. Hara, S; Terao, M; Tsuji-Hosokawa, A; Ogawa, Y; Takada, S. Humanization of a tandem repeat in IG-DMR causes stochastic restoration of paternal imprinting at mouse <i>Dlk1</i>-<i>Dio3</i> domain HUMAN MOLECULAR GENETICS. 2021.04; 30 (7): 564-574. ( PubMed, DOI )

  15. Gau M, Konishi K, Takasawa K, Nakagawa R, Tsuji-Hosokawa A, Hashimoto A, Sutani A, Tajima T, Hasegawa T, Morio T, Kashimada K. The progression of salt-wasting and the body weight change during the first 2 weeks of life in classical 21-hydroxylase deficiency patients. Clinical endocrinology. 2021.02; 94 (2): 229-236. ( PubMed, DOI )

  16. Yoko Saito, Kei Takasawa, Maki Gau, Takeru Yamauchi, Ryuichi Nakagawa, Yuichi Miyakawa, Akito Sutani, Atsumi Hosokawa-Tsuji, Shigeru Takishima, Yohei Matsubara, Tomohiro Morio, Kenichi Kashimada. Adrenal suppression and anthropometric data at two years of age was not influenced by the initial hydrocortisone dose in patients with 21-hydroxylase deficiency. Clin Pediatr Endocrinol. 2021; 30 (4): 155-161. ( PubMed, DOI )

  17. Rui Si, Qian Zhang, Jody Tori O Cabrera, Qiuyu Zheng, Atsumi Tsuji-Hosokawa, Makiko Watanabe, Susumu Hosokawa, Mingmei Xiong, Pritesh P Jain, Anthony W Ashton, Jason X-J Yuan, Jian Wang, Ayako Makino. Chronic Hypoxia Decreases Endothelial Connexin 40, Attenuates Endothelium-Dependent Hyperpolarization-Mediated Relaxation in Small Distal Pulmonary Arteries, and Leads to Pulmonary Hypertension. J Am Heart Assoc. 2020.12; 9 (24): e018327. ( PubMed, DOI )

  18. Rui Si, Qian Zhang, Atsumi Tsuji-Hosokawa, Makiko Watanabe, Conor Willson, Ning Lai, Jian Wang, Anzhi Dai, Brian T Scott, Wolfgang H Dillmann, Jason X-J Yuan, Ayako Makino. Overexpression of p53 due to excess protein O-GlcNAcylation is associated with coronary microvascular disease in type 2 diabetes. Cardiovasc Res. 2020.05; 116 (6): 1186-1198. ( PubMed, DOI )

  19. Qian Zhang, Atsumi Tsuji-Hosokawa, Conor Willson, Makiko Watanabe, Rui Si, Ning Lai, Ziyi Wang, Jason X-J Yuan, Jian Wang, Ayako Makino. Chloroquine differentially modulates coronary vasodilation in control and diabetic mice. Br J Pharmacol. 2020.01; 177 (2): 314-327. ( PubMed, DOI )

  20. Sutani A, Miyakawa Y, Tsuji-Hosokawa A, Nomura R, Nakagawa R, Nakajima K, Maru M, Aoki Y, Takasawa K, Takagi M, Imai K, Kashimada K, Morio T. Gonadal failure among female patients after hematopoietic stem cell transplantation for non-malignant diseases. Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology. 2019.10; 28 (4): 105-112. ( PubMed, DOI )

  21. Sutani Akito, Miyakawa Yuichi, Tsuji-Hosokawa Atsumi, Nomura Risa, Nakagawa Ryuichi, Nakajima Keisuke, Maru Mitsue, Aoki Yuki, Takasawa Kei, Takagi Masatoshi, Imai Kohsuke, Kashimada Kenichi, Morio Tomohiro. 非悪性疾患に対する造血幹細胞移植後の女性患者における性腺機能不全(Gonadal failure among female patients after hematopoietic stem cell transplantation for non-malignant diseases) Clinical Pediatric Endocrinology. 2019.10; 28 (4): 105-112. ( ichushi )

  22. Hasegawa S, Kumada S, Tanuma N, Tsuji-Hosokawa A, Kashimada A, Mizuno T, Moriyama K, Sugawara Y, Shirai I, Miyata Y, Nishida H, Mashimo H, Hasegawa T, Hosokawa T, Hisakawa H, Uematsu M, Fujine A, Miyata R, Sakuma H, Kashimada K, Imai K, Morio T, Hayashi M, Mizutani S, Takagi M. . Long-Term Evaluation of Low-Dose Betamethasone for Ataxia Telangiectasia. Pediatr Neurol. 2019.05; 100 60-66. ( PubMed, DOI )

  23. Nomura, R; Kashimada, K; Suzuki, H; Zhao, L; Tsuji-Hosokawa, A; Yagita, H; Takagi, M; Kanai, Y; Bowles, J; Koopman, P; Kanai-Azuma, M; Morio, T. <i>Nr5a1</i> suppression during the murine fetal period optimizes ovarian development by fine-tuning Notch signaling JOURNAL OF CELL SCIENCE. 2019.04; 132 (8): ( PubMed, DOI )

  24. Conor Willson, Makiko Watanabe, Atsumi Tsuji-Hosokawa, Ayako Makino. Pulmonary vascular dysfunction in metabolic syndrome. J Physiol. 2019.02; 597 (4): 1121-1141. ( PubMed, DOI )

  25. Takasawa K, Tsuji-Hosokawa A, Takishima S, Wada Y, Nagasaki K, Dateki S, Numakura C, Hijikata A, Shirai T, Kashimada K, Morio T. Clinical characteristics of adolescent cases with Type A insulin resistance syndrome caused by heterozygous mutations in the β-subunit of the insulin receptor (INSR) gene. Journal of diabetes. 2019.01; 11 (1): 46-54. ( PubMed, DOI )

  26. Tsuji-Hosokawa A, Kashimada K, Kato T, Ogawa Y, Nomura R, Takasawa K, Lavery R, Coschiera A, Schlessinger D, Harley VR, Takada S, Morio T. Peptidyl arginine deiminase 2 (Padi2) is expressed in Sertoli cells in a specific manner and regulated by SOX9 during testicular development. Scientific reports. 2018.09; 8 (1): 13263. ( PubMed, DOI )

  27. Matsuda Nozomi, Taki Atsuko, Tsuji Atsumi, Nakajima Keisuke, Takasawa Kei, Morioka Chikako, Minosaki Yoshihiro, Oku Kikuko, Kashimada Kenichi, Morio Tomohiro. 在胎週数の割に小さく産まれた超低出生体重児における3歳時点での成長と発達に影響を与える周産期要因(Perinatal factors affecting growth and development at age 3 years in extremely low birth weight infants born small for gestational age) Clinical Pediatric Endocrinology. 2018.01; 27 (1): 31-38. ( ichushi )

  28. Matsuda N, Taki A, Tsuji A, Nakajima K, Takasawa K, Morioka C, Minosaki Y, Oku K, Kashimada K, Morio T. Perinatal factors affecting growth and development at age 3 years in extremely low birth weight infants born small for gestational age. Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology. 2018; 27 (1): 31-38. ( PubMed, DOI )

  29. Tsuji-Hosokawa A, Takasawa K, Nomura R, Miyakawa Y, Numakura C, Hijikata A, Shirai T, Ogawa Y, Kashimada K, Morio T. Molecular mechanisms of insulin resistance in 2 cases of primary insulin receptor defect-associated diseases. Pediatric diabetes. 2017.12; 18 (8): 917-924. ( PubMed, DOI )

  30. Atsumi Tsuji-Hosokawa, Nozomi Matsuda, Kenji Kurosawa, Kenichi Kashimada, Tomohiro Morio. A Case of MECP2 Duplication Syndrome with Gonadotropin-Dependent Precocious Puberty. Horm Res Paediatr. 2016.09; 87 (4): 271-276. ( PubMed, DOI )

  31. Tomohiro Kohmoto, Atsumi Tsuji, Kei-Ichi Morita, Takuya Naruto, Kiyoshi Masuda, Kenichi Kashimada, Keisuke Enomoto, Tomohiro Morio, Hiroyuki Harada, Issei Imoto. A novel COL11A1 missense mutation in siblings with non-ocular Stickler syndrome. Human Genome Variation. 2016; 3 16003. ( PubMed, DOI )

  32. Atsumi Tsuji, Kaoru Konishi, Satomi Hasegawa, Akira Anazawa, Toshikazu Onishi, Makoto Ono, Tomohiro Morio, Teruo Kitagawa, Kenichi Kashimada. Newborn screening for congenital adrenal hyperplasia in Tokyo, Japan from 1989 to 2013: a retrospective population-based study. BMC Pediatr. 2015; 15 (1): 209. ( PubMed, DOI )

  33. Tamura Kazuyo, Matsubara Kousaku, Ishiwada Naruhiko, Nishi Junichiro, Ohnishi Hidenori, Suga Shigeru, Ihara Toshiaki, Chang Bin, Akeda Yukihiro, Oishi Kazunori, Japanese IPD Study Group. Hyporesponsiveness to the infecting serotype after vaccination of children with seven-valent pneumococcal conjugate vaccine following invasive pneumococcal disease. Vaccine. 2014.03; 32 (13): 1444-1450. ( PubMed, DOI )

▼display all

To the head of this page.▲

Conference Activities & Talks 【 display / non-display 】

  1. Atsumi Tsuji-Hosokawa, Kenichi Kashimada. The thirty-year lesson from the newborn screening for congenital adrenal hyperplasia in Tokyo. APPES 2021 2021.10.26 online

  2. Atsumi Tsuji-Hosokawa et al.. Excessive Protein O-GlcNAcylation Contributes to the Development of Coronary Microvascular Disease in Type 2 Diabetic Mice. AHA 2018 2018.11.10 Chicago, IL, USA

  3. Atsumi Tsuji-Hosokawa et al.. Role of Nicotinamide Phosphoribosyltransferase in Coronary Microvascular Disease in Type 2 Diabetes. AHA 2018 2018.11.10

  4. Atsumi Tsuji-Hosokawa et al.. SOX9 And FOXL2 Antagonistically Regulate Peptidyl Arginine Deiminase 2 (Padi2) Expression During Testicular Development. ENDO 2018 2018.03.17

  5. Atsumi Tsuji, Kei Takasawa, Risa Nomura, Yuichi Miyakawa, Chikahiko Numakura, Atsushi Hijikata, Tsuyoshi Shirai, Yoshihiro Ogawa, Kashimada, Tomohiro Morio. Molecular mechanisms of insulin resistance in two cases of primary insulin receptor defect-associated diseases. The 9th biennial scientific meeting of the Asia Pacific Paediatric Endocrine Society 2016.10.19 Tokyo, Japan

  6. Atsumi Tsuji, Kaoru Konishi, Satomi Hasegawa, Akira Anazawa, Teruo Kitagawa, Shuki Mizutani, Kenichi Kashimada. Newborn screening for congenital adrenal hyperplasia(CAH) in Tokyo, Japan: Lessons learned from 23 years’ experience. the 9th Joint Meeting of Paediatric Endocrinology 2013.09 Milan, Italy

▼display all

To the head of this page.▲