Graduating School 【 display / non-display 】
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Hokkaido University, Faculty of Pharmaceutical Science, Graduated
Campus Career 【 display / non-display 】
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2014.04-2015.03Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Advanced Therapeutic Sciences, Systems BioMedicine, Medical fellow
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2014.04-2018.03Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Advanced Therapeutic Sciences, Systems BioMedicine, Assistant Professor
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2018.04-2018.12Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Advanced Therapeutic Sciences, Systems BioMedicine, Assistant Professor
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2019.01-2020.05Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Advanced Therapeutic Sciences, Systems BioMedicine, Assistant Professor
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2020.06-NowTokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Advanced Therapeutic Sciences, Systems BioMedicine, Assistant Professor
Research Areas 【 display / non-display 】
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Clinical pharmacy
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Immunology
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Molecular biology
Research Theme 【 display / non-display 】
Published Papers & Misc 【 display / non-display 】
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Takahide Matsushima, Asahara Hiroshi. "Molecular mechanisms of mechanosensing and plasticity of tendons and ligaments". J Biochem. 2024.05; ( PubMed, DOI )
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Maiko Inotsume, Tomoki Chiba, Takahide Matsushima, Ryota Kurimoto, Mitsuyo Nakajima, Tomomi Kato, Kana Shishido, Lin Liu, Koichi Kawakami, Hiroshi Asahara. One-step generation of mice with gene editing by Tol2 transposon-dependent gRNA delivery. FEBS Lett. 2023.03; 597 (7): 975-984. ( PubMed, DOI )
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Hiroto Yamamoto, Yutaro Uchida, Ryota Kurimoto, Tomoki Chiba, Takahide Matsushima, Yoshiaki Ito, Maiko Inotsume, Kohei Miyata, Kenta Watanabe, Masaki Inada, Naoki Goshima, Tokujiro Uchida, Hiroshi Asahara. RNA-binding protein LIN28A upregulates transcription factor HIF1α by posttranscriptional regulation via direct binding to UGAU motifs. J Biol Chem. 2023.01; 299 (1): 102791. ( PubMed, DOI )
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Hiroki Tsutsumi, Ryota Kurimoto, Ryo Nakamichi, Tomoki Chiba, Takahide Matsushima, Yuta Fujii, Risa Sanada, Tomomi Kato, Kana Shishido, Yuriko Sakamaki, Tsuyoshi Kimura, Akio Kishida, Hiroshi Asahara. Generation of a tendon-like tissue from human iPS cells. J Tissue Eng. 2022.01; 13 20417314221074018. ( PubMed, DOI )
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Miyazaki Takayuki, Kurimoto Ryota, Chiba Tomoki, Matsushima Takahide, Nakamichi Ryo, Tsutsumi Hiroki, Takada Kaho, Yagasaki Lisa, Kato Tomomi, Shishido Kana, Kobayashi Yukiho, Matsumoto Tsutomu, Moriyama Keiji, Asahara Hiroshi. Mkxは破骨細胞の誘導を介して歯科矯正による歯の移動を制御する(Mkx regulates the orthodontic tooth movement via osteoclast induction) Journal of Bone and Mineral Metabolism. 2021.09; 39 (5): 780-786. ( ichushi )
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Yoshiaki Ito, Tokio Matsuzaki, Fumiaki Ayabe, Sho Mokuda, Ryota Kurimoto, Takahide Matsushima, Yusuke Tabata, Maiko Inotsume, Hiroki Tsutsumi, Lin Liu, Masahiro Shinohara, Yoko Tanaka, Ryo Nakamichi, Keiichiro Nishida, Martin K Lotz, Hiroshi Asahara. Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis. Nat Commun. 2021.07; 12 (1): 4148. ( PubMed, DOI )
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Takayuki Miyazaki, Ryota Kurimoto, Tomoki Chiba, Takahide Matsushima, Ryo Nakamichi, Hiroki Tsutsumi, Kaho Takada, Lisa Yagasaki, Tomomi Kato, Kana Shishido, Yukiho Kobayashi, Tsutomu Matsumoto, Keiji Moriyama, Hiroshi Asahara. Mkx regulates the orthodontic tooth movement via osteoclast induction. J Bone Miner Metab. 2021.05; 39 (5): 780-786. ( PubMed, DOI )
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Yutaro Uchida, Takahide Matsushima, Ryota Kurimoto, Tomoki Chiba, Yuki Inutani, Hiroshi Asahara. Identification of chemical compounds regulating PD-L1 by introducing HiBiT-tagged cells. FEBS Lett. 2021.03; 595 (5): 563-576. ( PubMed, DOI )
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Chiba T, Kurimoto R, Matsushima T, Ito Y, Nakamichi R, Lotz M, Asahara H. MicroRNA Expression Profiling, Target Identification, and Validation in Chondrocytes. Methods in molecular biology (Clifton, N.J.). 2021; 2245 151-166. ( PubMed, DOI )
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Keiko Itano,KojiOchiai, Takahide Matsushima,Hiroshi Asahara and Koichi Takahashi. Automation of Foci-Cell-State Judgement with Regression Models Transactions of the Institute of Systems, Control and Information Engineers. 2021; 34 (3): 69-80. ( DOI )
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Kurimoto R, Chiba T, Ito Y, Matsushima T, Yano Y, Miyata K, Yashiro Y, Suzuki T, Tomita K, Asahara H. The tRNA pseudouridine synthase TruB1 regulates the maturation of let-7 miRNA. The EMBO journal. 2020.10; 39 (20): e104708. ( PubMed, DOI )
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Yamamoto H, Uchida Y, Chiba T, Kurimoto R, Matsushima T, Inotsume M, Ishikawa C, Li H, Shiga T, Muratani M, Uchida T, Asahara H. Transcriptome analysis of sevoflurane exposure effects at the different brain regions. PloS one. 2020; 15 (12): e0236771. ( PubMed, DOI )
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Mitsumura T, Ito Y, Chiba T, Matsushima T, Kurimoto R, Tanaka Y, Kato T, Uchida K, Ito T, Yamamoto K, Eishi Y, Kitagawa M, Miyazaki Y, Inase N, Asahara H. Ablation of miR-146b in mice causes hematopoietic malignancy. Blood advances. 2018.12; 2 (23): 3483-3491. ( PubMed, DOI )
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Kataoka K, Matsushima T, Ito Y, Sato T, Yokoyama S, Asahara H. Bhlha9 regulates apical ectodermal ridge formation during limb development. JBMM. 2018.01; 36 (1): 64-72.
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Kataoka K, Matsushima T, Ito Y, Sato T, Yokoyama S, Asahara H. Bhlha9 regulates apical ectodermal ridge formation during limb development. Journal of bone and mineral metabolism. 2018.01; 36 (1): 64-72. ( PubMed, DOI )
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Yachie Nozomu, Natsume Tohru, Takahashi Koichi, Katayama Toshiaki, Sakurada Takeshi, Kanda Genki N., Takagi Eiji, Hirose Takako, Katsura Tatsuo, Moriya Tetsuo, Kitano Hiroaki, Tsujii Junichi, Natsume Tohru, Shiraki Tomoyuki, Kariyazaki Hirokazu, Kamei Motohisa, Abe Noriko, Fukuda Takuya, Sawada Yukiko, Hashiguchi Yukio, Matsukuma Kenji, Murai Shinji, Sasaki Naoyuki, Ipposhi Tatsuro, Urabe Hideo, Kudo Taku, Umeno Makoto, Ono Seiki, Miyauchi Kohei, Nakamura Miki, Kizaki Takahiro, Suyama Takashi, Hatta Tomohisa, Natsume Tohru, Ohta Tazro, Takahashi Koichi, Ozawa Yosuke, Yachie Nozomu, Sakurada Takeshi, Matsukuma Kenji, Murai Shinji, Ihara Shoji, Tamaki Satoshi, Antezana Erick, Garcia-Castro Alexander, Perret Jean-Luc, Ishiguro Soh, Mori Hideto, Evans-Yamamoto Daniel, Masuyama Nanami, Tomita Masaru, Tsujii Junichi, Katayama Toshiaki, Kitano Hiroaki, Hatta Tomohisa, Matsumoto Masaki, Nakayama Hiroshi, Shirasawa Ayaka, Shimbo Kazutaka, Yamada Naoyuki, Nakayama Keiichi I., Natsume Tohru, Shimizu Takatsune, Saya Hideyuki, Yamashita Satoshi, Matsushima Takahide, Asahara Hiroshi, Eguchi Hidetoshi, Mikamori Manabu, Mori Masaki. Robotic crowd biology with Maholo LabDroids NATURE BIOTECHNOLOGY. 2017.04; 35 (4): 310-312. ( DOI )
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Kayama Tomohiro, Mori Masaki, Ito Yoshiaki, Matsushima Takahide, Nakamichi Ryo, Suzuki Hidetsugu, Ichinose Shizuko, Saito Mitsuru, Marumo Keishi, Asahara Hiroshi. コラーゲン線維の成熟における腱/靱帯特異的Mohawk(Mkx)遺伝子の機械調節転写ネットワークの関与(Mechanoregulatory transcriptional network converges to tendon/ligament-specific Mohawk(Mkx) gene for collagen fiber maturation) 日本整形外科学会雑誌. 2017.03; 91 (3): S788. ( ichushi )
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Kayama T, Mori M, Ito Y, Matsushima T, Nakamichi R, Suzuki H, Ichinose S, Saito M, Marumo K, Asahara H. Gtf2ird1-Dependent Mohawk Expression Regulates Mechanosensing Properties of the Tendon. Molecular and cellular biology. 2016.04; 36 (8): 1297-309. ( PubMed, DOI )
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Chiba K, Araseki M, Nozawa K, Furukori K, Araki Y, Matsushima T, Nakaya T, Hata S, Saito Y, Uchida S, Okada Y, Nairn AC, Davis RJ, Yamamoto T, Kinjo M, Taru H, Suzuki T. Quantitative analysis of APP axonal transport in neurons: role of JIP1 in enhanced APP anterograde transport. Molecular biology of the cell. 2014.11; 25 (22): 3569-80. ( PubMed, DOI )
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Hoshino T, Suzuki K, Matsushima T, Yamakawa N, Suzuki T, Mizushima T. Suppression of Alzheimer's disease-related phenotypes by geranylgeranylacetone in mice. PloS one. 2013; 8 (10): e76306. ( PubMed, DOI )
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Matsushima T, Saito Y, Elliott JI, Iijima-Ando K, Nishimura M, Kimura N, Hata S, Yamamoto T, Nakaya T, Suzuki T. Membrane-microdomain localization of amyloid β-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue. The Journal of biological chemistry. 2012.06; 287 (23): 19715-24. ( PubMed, DOI )
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Hoshino T, Namba T, Takehara M, Murao N, Matsushima T, Sugimoto Y, Narumiya S, Suzuki T, Mizushima T. Improvement of cognitive function in Alzheimer's disease model mice by genetic and pharmacological inhibition of the EP(4) receptor. Journal of neurochemistry. 2012.03; 120 (5): 795-805. ( PubMed, DOI )
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Hoshino T, Murao N, Namba T, Takehara M, Adachi H, Katsuno M, Sobue G, Matsushima T, Suzuki T, Mizushima T. Suppression of Alzheimer's disease-related phenotypes by expression of heat shock protein 70 in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011.04; 31 (14): 5225-34. ( PubMed, DOI )
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Kondo M, Shiono M, Itoh G, Takei N, Matsushima T, Maeda M, Taru H, Hata S, Yamamoto T, Saito Y, Suzuki T. Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain. Molecular neurodegeneration. 2010.09; 5 35. ( PubMed, DOI )
Conference Activities & Talks 【 display / non-display 】
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Ryota Kurimoto、Waka Miyamoto、Maiko Inotsume、Reiji Hirai、Tomoki Chiba、Takahide Matsushima、Yutaro Uchida、Yuta Fujii、Yuki Naito、Yuichi Shichino、Mari Mito、Shintaro Iwasaki、Hiroshi Asahara. Regulation of lung cancer metastasis by the RNA-modifying enzyme. 第24回日本RNA学会年会 2023.07.05
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Ryota Kurimoto, Waka Miyamoto, Maiko Inotsume, Tomoki Chiba, TakahideMatsushima, YutaroUchida, Yuta Fujii, Hiroshi Asahara.. Regulation of lung cancer metastasis by the RNA-modifying enzyme. 2022.07.21
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Endogenous protein analysis using genome editing technology and HiBiT system. Discover Glo 2021 2021.09.14
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Yutaro Uchida, Takahide Matsushima, Ryota Kurimoto, Tomoki Chiba, Yuki lnutani, Hiroshi Asahara.. HiBiT tagging system for high throughput chemical screening for chemotherapy. AACR 2021 2021.04.11
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松島隆英、淺原弘嗣、. Localizatome Project:タンパク質の網羅的細胞内ダイナミクス解析. 第43回日本分子生物学会 2020.12.02 web
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Hiroshi Asahara, Sho Mokuda, Yoshiaki Ito, Masafumi Inui, Ryo Nakamichi, Tomoki Chiba, Ryota Kurimoto, Takahide Matsushima. miRNAs in arthritis pathogenesis and therapy. The 24th Annual Meeting of the RNA Society 2019.06.14