Personnel Information

写真a

Jiyoung Lee


Job title

Visiting Lecturer
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Graduate School 【 display / non-display 】

  • Tokyo Institute of Technology, Graduate School, Division of Life Science and Engineering, Doctor's Course, 2002.03, Completed

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Campus Career 【 display / non-display 】

  • 2014.01
    -
    2014.12
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Life Science and Technology， Life Science and Technology， Epigenetics， Project Junior Associate Professor
  • 2014.01
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    2014.12
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Systemic Organ Regulation， Epigenetics， Project Junior Associate Professor
  • 2014.04
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    2016.09
    Tokyo Medical and Dental University， Medical Research Institute， Medical Genomics， Epigenetics， Junior Associate Professor
  • 2016.10
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    2017.03
    Tokyo Medical and Dental University， Medical Research Institute， Medical Genomics， Epigenetics， Junior Associate Professor
  • 2017.04
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    2018.04
    Tokyo Medical and Dental University， Medical Research Institute， Medical Genomics， Epigenetics， Junior Associate Professor
  • 2018.05
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    2021.03
    Tokyo Medical and Dental University， Medical Research Institute， Medical Genomics， Epigenetics， Associate Professor
  • 2021.04
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    2022.02
    Tokyo Medical and Dental University， Institute of Research， Division of Advanced Research， Associate Professor
  • 2022.03
    　
    　
    Tokyo Medical and Dental University， Institute of Research， a， Associate Professor
  • 2022.04
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    2023.04
    Tokyo Medical and Dental University， Institute of Research， Research Facility Cluster， Center for Experimental Animals， Visiting Lecturer
  • 2023.05
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    Now
    Tokyo Medical and Dental University， Institute of Research， Research Facility Cluster， Center for Experimental Animals， Visiting Lecturer

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Published Papers & Misc 【 display / non-display 】

  1. Matsuzawa Ayumi, Lee Jiyoung, Nakagawa So, Itoh Johbu, Takahashi Ueda Mahoko, Mitsuhashi Satomi, Kochi Yuta, Kaneko-Ishino Tomoko, Ishino Fumitoshi. HERV-Derived Ervpb1 Is Conserved in Simiiformes, Exhibiting Expression in Hematopoietic Cell Lineages Including Macrophages INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021.05; 22 (9): ( DOI )

  2. Lee J, Matsuzawa A, Shiura H, Sutani A, Ishino F. Preferable in vitro condition for maintaining faithful DNA methylation imprinting in mouse embryonic stem cells. Genes to cells : devoted to molecular & cellular mechanisms. 2018.03; 23 (3): 146-160. ( PubMed, DOI )

  3. Kamimura S, Hatanaka Y, Hirasawa R, Matsumoto K, Oikawa M, Lee J, Matoba S, Mizutani E, Ogonuki N, Inoue K, Kohda T, Ishino F, Ogura A. Establishment of paternal genomic imprinting in mouse prospermatogonia analyzed by nuclear transfer. Biology of reproduction. 2014.11; 91 (5): 120. ( PubMed, DOI )

  4. Takahashi S, Lee J, Kohda T, Matsuzawa A, Kawasumi M, Kanai-Azuma M, Kaneko-Ishino T, Ishino F. Induction of the G2/M transition stabilizes haploid embryonic stem cells. Development (Cambridge, England). 2014.10; 141 (20): 3842-7. ( PubMed, DOI )

  5. Kawasaki Y, Lee J, Matsuzawa A, Kohda T, Kaneko-Ishino T, Ishino F. Active DNA demethylation is required for complete imprint erasure in primordial germ cells. Scientific reports. 2014.01; 4 3658. ( PubMed, DOI )

  6. Shiura H, Ikeda R, Lee J, Sato T, Ogonuki N, Hirose M, Ogura A, Ogawa T, Abe K. Generation of a novel germline stem cell line expressing a germline-specific reporter in the mouse. Genesis (New York, N.Y. : 2000). 2013.07; 51 (7): 498-505. ( PubMed, DOI )

  7. Morimoto H, Lee J, Tanaka T, Ishii K, Toyokuni S, Kanatsu-Shinohara M, Shinohara T. In vitro transformation of mouse testis cells by oncogene transfection. Biology of reproduction. 2012.05; 86 (5): 148, 1-11. ( PubMed, DOI )

  8. Takashima S, Takehashi M, Lee J, Chuma S, Okano M, Hata K, Suetake I, Nakatsuji N, Miyoshi H, Tajima S, Tanaka Y, Toyokuni S, Sasaki H, Kanatsu-Shinohara M, Shinohara T. Abnormal DNA methyltransferase expression in mouse germline stem cells results in spermatogenic defects. Biology of reproduction. 2009.07; 81 (1): 155-64. ( PubMed, DOI )

  9. Lee J, Kanatsu-Shinohara M, Morimoto H, Kazuki Y, Takashima S, Oshimura M, Toyokuni S, Shinohara T. Genetic reconstruction of mouse spermatogonial stem cell self-renewal in vitro by Ras-cyclin D2 activation. Cell stem cell. 2009.07; 5 (1): 76-86. ( PubMed, DOI )

  10. Lee J, Kanatsu-Shinohara M, Ogonuki N, Miki H, Inoue K, Morimoto T, Morimoto H, Ogura A, Shinohara T. Heritable imprinting defect caused by epigenetic abnormalities in mouse spermatogonial stem cells. Biology of reproduction. 2009.03; 80 (3): 518-27. ( PubMed, DOI )

  11. Kanatsu-Shinohara M, Takehashi M, Takashima S, Lee J, Morimoto H, Chuma S, Raducanu A, Nakatsuji N, Fässler R, Shinohara T. Homing of mouse spermatogonial stem cells to germline niche depends on beta1-integrin. Cell stem cell. 2008.11; 3 (5): 533-42. ( PubMed, DOI )

  12. Kanatsu-Shinohara M, Muneto T, Lee J, Takenaka M, Chuma S, Nakatsuji N, Horiuchi T, Shinohara T. Long-term culture of male germline stem cells from hamster testes. Biology of reproduction. 2008.04; 78 (4): 611-7. ( PubMed, DOI )

  13. Kanatsu-Shinohara M, Lee J, Inoue K, Ogonuki N, Miki H, Toyokuni S, Ikawa M, Nakamura T, Ogura A, Shinohara T. Pluripotency of a single spermatogonial stem cell in mice. Biology of reproduction. 2008.04; 78 (4): 681-7. ( PubMed, DOI )

  14. Takehashi M, Kanatsu-Shinohara M, Miki H, Lee J, Kazuki Y, Inoue K, Ogonuki N, Toyokuni S, Oshimura M, Ogura A, Shinohara T. Production of knockout mice by gene targeting in multipotent germline stem cells. Developmental biology. 2007.12; 312 (1): 344-52. ( PubMed, DOI )

  15. Lee J, Kanatsu-Shinohara M, Inoue K, Ogonuki N, Miki H, Toyokuni S, Kimura T, Nakano T, Ogura A, Shinohara T. Akt mediates self-renewal division of mouse spermatogonial stem cells. Development (Cambridge, England). 2007.05; 134 (10): 1853-9. ( PubMed, DOI )

  16. Kanatsu-Shinohara M, Inoue K, Ogonuki N, Miki H, Yoshida S, Toyokuni S, Lee J, Ogura A, Shinohara T. Leukemia inhibitory factor enhances formation of germ cell colonies in neonatal mouse testis culture. Biology of reproduction. 2007.01; 76 (1): 55-62. ( PubMed, DOI )

  17. Shinohara T, Kato M, Takehashi M, Lee J, Chuma S, Nakatsuji N, Kanatsu-Shinohara M, Hirabayashi M. Rats produced by interspecies spermatogonial transplantation in mice and in vitro microinsemination. Proceedings of the National Academy of Sciences of the United States of America. 2006.09; 103 (37): 13624-8. ( PubMed, DOI )

  18. Imamura M, Miura K, Iwabuchi K, Ichisaka T, Nakagawa M, Lee J, Kanatsu-Shinohara M, Shinohara T, Yamanaka S. Transcriptional repression and DNA hypermethylation of a small set of ES cell marker genes in male germline stem cells. BMC developmental biology. 2006.07; 6 34. ( PubMed, DOI )

  19. Kanatsu-Shinohara M, Ikawa M, Takehashi M, Ogonuki N, Miki H, Inoue K, Kazuki Y, Lee J, Toyokuni S, Oshimura M, Ogura A, Shinohara T. Production of knockout mice by random or targeted mutagenesis in spermatogonial stem cells. Proceedings of the National Academy of Sciences of the United States of America. 2006.05; 103 (21): 8018-23. ( PubMed, DOI )

  20. Kanatsu-Shinohara M, Inoue K, Lee J, Miki H, Ogonuki N, Toyokuni S, Ogura A, Shinohara T. Anchorage-independent growth of mouse male germline stem cells in vitro. Biology of reproduction. 2006.03; 74 (3): 522-9. ( PubMed, DOI )

  21. Kanatsu-Shinohara M, Ogonuki N, Iwano T, Lee J, Kazuki Y, Inoue K, Miki H, Takehashi M, Toyokuni S, Shinkai Y, Oshimura M, Ishino F, Ogura A, Shinohara T. Genetic and epigenetic properties of mouse male germline stem cells during long-term culture. Development (Cambridge, England). 2005.09; 132 (18): 4155-63. ( PubMed, DOI )

  22. Isotani A, Nakanishi T, Kobayashi S, Lee J, Chuma S, Nakatsuji N, Ishino F, Okabe M. Genomic imprinting of XX spermatogonia and XX oocytes recovered from XXXY chimeric testes. Proceedings of the National Academy of Sciences of the United States of America. 2005.03; 102 (11): 4039-44. ( PubMed, DOI )

  23. Kanatsu-Shinohara M, Inoue K, Lee J, Yoshimoto M, Ogonuki N, Miki H, Baba S, Kato T, Kazuki Y, Toyokuni S, Toyoshima M, Niwa O, Oshimura M, Heike T, Nakahata T, Ishino F, Ogura A, Shinohara T. Generation of pluripotent stem cells from neonatal mouse testis. Cell. 2004.12; 119 (7): 1001-12. ( PubMed, DOI )

  24. Miki H, Lee J, Inoue K, Ogonuki N, Noguchi Y, Mochida K, Kohda T, Nagashima H, Ishino F, Ogura A. Microinsemination with first-wave round spermatids from immature male mice. The Journal of reproduction and development. 2004.02; 50 (1): 131-7. ( PubMed )

  25. Lee J, Inoue K, Ono R, Ogonuki N, Kohda T, Kaneko-Ishino T, Ogura A, Ishino F. Erasing genomic imprinting memory in mouse clone embryos produced from day 11.5 primordial germ cells. Development (Cambridge, England). 2002.04; 129 (8): 1807-17. ( PubMed )

  26. Inoue K, Kohda T, Lee J, Ogonuki N, Mochida K, Noguchi Y, Tanemura K, Kaneko-Ishino T, Ishino F, Ogura A. Faithful expression of imprinted genes in cloned mice. Science (New York, N.Y.). 2002.01; 295 (5553): 297. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Jiyoung Lee. In vitro generation of heart organoids with functional capacity.. 第85回日本循環器学会 2021.03.26

  2. Lee J. Epigenetic instability of imprinting regions in mouse embryonic stem cells caused by in vitro environments.. KEY Forum: The 3rd International Symposium on Stem Cell Traits and Developmental Systems 2018.01.12

  3. 李　知英、松沢歩、高橋沙央里、石野史敏. ES細胞のインプリンティング領域DNAメチル化揺らぎと幹細胞活性における培養条件の影響. 第10回日本エピジェネティクス研究会年会 2016.05.19

  4. Lee J, Kawasaki Y, Matsuzawa A, Kaneko-Ishino T, Ishino F. . BER-mediated, active DNA demethylation for complete imprint erasure in primordial germ cells.. International Symposium on “Epigenome dynamics and regulation in germ cells” 2016.02.17

  5. 三木 洋美, 李 知英, 井上 貴美子, 越後貫 成美, 野口 洋子, 持田 慶司, 幸田 尚, 長嶋 比呂志, 石野 史敏, 小倉 淳郎. 未成熟雄マウス由来first-wave円形精子細胞を用いた顕微授精(Microinsemination with First-Wave Round Spermatids from Immature Male Mice). The Journal of Reproduction and Development 2004.02.01

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Others 【 display / non-display 】

  • Generation of three-dimensional heart organoids，2020.09

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