Personnel Information

写真a

IWAI Hideyuki


Job title

Project Junior Associate Professor

Research Areas, Keywords

rheumatology
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Graduating School 【 display / non-display 】

  • Tokyo Medical and Dental University, Faculty of Medicine, Graduated

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Graduate School 【 display / non-display 】

  • Tokyo Medical and Dental University, Graduate School, Division of Medical Sciences, Doctor's Course, Completed

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Campus Career 【 display / non-display 】

  • 2009.01
    -
    2016.02
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Environmental Response， Rheumatology， Project Junior Associate Professor
  • 2014.04
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    2018.03
    Tokyo Medical and Dental University， Faculty of Medicine， Project Junior Associate Professor
  • 2018.04
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    2019.10
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Internal Medicine， Rheumatology， Project Junior Associate Professor
  • 2018.04
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    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Environmental Response， Rheumatology， Project Junior Associate Professor
  • 2019.11
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    2021.09
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Internal Medicine， Rheumatology， Project Junior Associate Professor
  • 2021.10
    -
    Now
    Tokyo Medical and Dental University， Tokyo Medical and Dental University， Division of Clinical Medicine， Department of Internal Medicine， Rheumatology， Project Junior Associate Professor

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Research Areas 【 display / non-display 】

  • Connective tissue disease and allergy

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Qualification Acquired 【 display / non-display 】

  • Doctor

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Published Papers & Misc 【 display / non-display 】

  1. Komiya Y, Kamiya M, Oba S, Kawata D, Iwai H, Shintaku H, Suzuki Y, Miyamoto S, Tobiume M, Kanno T, Ainai A, Suzuki T, Hasegawa H, Hosoya T, Yasuda S. Necroptosis in alveolar epithelial cells drives lung inflammation and injury caused by SARS-CoV-2 infection. Biochimica et biophysica acta. Molecular basis of disease. 2024.12; 1870 (8): 167472. ( PubMed, DOI )

  2. Tsujikawa, T; Ohno, K; Morita, K; Saburi, S; Mitsuda, J; Yoshimura, K; Kimura, A; Morimoto, H; Ogi, H; Shibata, S; Akashi, T; Kurata, M; Imoto, I; Shimizu, Y; Kano, S; Watanabe, A; Yamazaki, T; Asada, Y; Hayashi, R; Saito, Y; Ozawa, H; Tsukahara, K; Oridate, N; Sano, D; Horii, A; Ueki, Y; Maruo, T; Mukoyama, N; Hanai, N; Fukusumi, T; Iwai, H; Fujisawa, T; Fujii, T; Nibu, K; Iwae, S; Ueda, T; Chikuie, N; Yasumatsu, R; Matsuo, M; Umeno, H; Ono, T; Masuda, M; Toh, S; Itoh, K; Hirano, S; Asakage, T. Clinical, genomic and immune microenvironmental determinants of nivolumab response in head and neck squamous cell carcinoma FRONTIERS IN IMMUNOLOGY. 2024.07; 15 1390873. ( PubMed, DOI )

  3. Kawata, D; Iwai, H; Oba, S; Komiya, Y; Koike, R; Miyamoto, S; Kanno, T; Ainai, A; Suzuki, T; Hosoya, T; Yasuda, S. Diverse pro-inflammatory ability of mutated spike protein derived from variant strains of SARS-CoV-2 CYTOKINE. 2024.06; 178 156592. ( PubMed, DOI )

  4. Tagawa Y, Saito T, Iwai H, Sato M, Noda S, Yamamoto A, Ota M, Endo K, Koga H, Takahara Y, Sugimoto K, Sekiya I, Fujio K, Kawakami E, Mizoguchi F, Yasuda S. ARID5B is a negative modulator of IL-6 production in rheumatoid arthritis synovial fibroblasts. Immunological medicine. 2024.05; 47 (3): 1-10. ( PubMed, DOI )

  5. Sasaki, H; Umezawa, N; Itakura, T; Iwai, H; Yasuda, S. Pathogenicity of functionally activated PD-1<SUP>+</SUP>CD8<SUP>+</SUP> cells and counterattacks by muscular PD-L1 through IFNγ in myositis JOURNAL OF AUTOIMMUNITY. 2024.01; 142 103131. ( PubMed, DOI )

  6. Hidaka H, Tarasawa K, Fujimori K, Obara T, Fushimi K, Shimamura A, Iwai H. Identification of Risk Factors for Mortality and Prolonged Hospitalization in Patients Treated With Surgical Drainage for Otogenic Intracranial Complications: A Nationwide Study Using a Japanese Inpatient Database. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. 2023.12; 44 (10): 1027-1032. ( PubMed, DOI )

  7. Hosoya T, Oba S, Komiya Y, Kawata D, Kamiya M, Iwai H, Miyamoto S, Kataoka M, Tobiume M, Kanno T, Ainai A, Sato H, Hirakawa A, Mitsui Y, Satoh T, Wakabayashi K, Yamada T, Otomo Y, Miyazaki Y, Hasegawa H, Suzuki T, Yasuda S. Apple-shaped obesity: A risky soil for cytokine-accelerated severity in COVID-19. Proceedings of the National Academy of Sciences of the United States of America. 2023.05; 120 (22): e2300155120. ( PubMed, DOI )

  8. Noda S, Honda S, Hirota Y, Ito T, Hasegawa H, Kimura N, Matsuo Y, Iwai H, Kohsaka H, Yasuda S. Azathioprine Monotherapy for the Cases of Immunoglobulin G4-Related Disease With Contraindications to Glucocorticoids. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases. 2021.12; 27 (8S): S327-S330. ( PubMed, DOI )

  9. Shunsuke Furuta, Daiki Nakagomi, Yoshihisa Kobayashi, Masaki Hiraguri, Takao Sugiyama, Koichi Amano, Takeshi Umibe, Hajime Kono, Kazuhiro Kurasawa, Yasuhiko Kita, Ryutaro Matsumura, Yuko Kaneko, Keita Ninagawa, Keiju Hiromura, Shin-Ichiro Kagami, Yosuke Inaba, Hideki Hanaoka, Kei Ikeda, Hiroshi Nakajima, . Effect of Reduced-Dose vs High-Dose Glucocorticoids Added to Rituximab on Remission Induction in ANCA-Associated Vasculitis: A Randomized Clinical Trial. JAMA. 2021.01; 325 (21): 2178-2187. ( PubMed, DOI )

  10. Mineto Ota, Hideyuki Iwai, Kaori Imai, Mari Kamiya, Yoko Yoshihashi-Nakazato, Nobuyuki Miyasaka, Hitoshi Kohsaka. Acute Tubulointerstitial Nephritis Associated with Infliximab in a Patient with Crohn's Disease. Intern. Med.. 2016; 55 (10): 1367-1370. ( PubMed, DOI )

  11. Tadashi Hosoya, Hideyuki Iwai, Yu Yamaguchi, Kimito Kawahata, Nobuyuki Miyasaka, Hitoshi Kohsaka. Cell cycle regulation therapy combined with cytokine blockade enhances antiarthritic effects without increasing immune suppression. Annals of the rheumatic diseases, Tokyo Medical and Dental University. 2014.08; ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Sasaki Hirokazu, Umezawa Natsuka, Itakura Takuji, Iwai Hideyuki, Yasuda Shinsuke. Inflammatory myopathies 2　Pathogenicity of functionally activated PD-1+CD8+ cells and a protective role of muscular PD-L1 through IFN-gamma in myositis(タイトル和訳中). 日本リウマチ学会総会・学術集会プログラム・抄録集 2024.03.01

  2. Hosoya Tadashi, Oba Seiya, Komiya Yoji, Kawata Daisuke, Kamiya Mari, Iwai Hideyuki, Miyamoto Sho, Kanno Takayuki, Ainai Akira, Suzuki Tadaki, Hasegawa Hideki, Yasuda Shinsuke. Infection and Immunity II(The underlying mechanism of the deterioration in obese patients with COVID-19). 日本免疫学会総会・学術集会記録 2022.11.01

  3. Hosoya Tadashi, Oba Seiya, Komiya Yoji, Kawata Daisuke, Kamiya Mari, Iwai Hideyuki, Miyamoto Sho, Kanno Takayuki, Ainai Akira, Suzuki Tadaki, Hasegawa Hideki, Yasuda Shinsuke. 感染と免疫II　COVID-19の肥満患者における悪化の根本的なメカニズム(Infection and Immunity II　The underlying mechanism of the deterioration in obese patients with COVID-19). 日本免疫学会総会・学術集会記録 2022.11.01

  4. Hosoya Tadashi, Oba Seiya, Komiya Yoji, Kawata Daisuke, Kamiya Mari, Iwai Hideyuki, Miyamoto Sho, Kanno Takayuki, Ainai Akira, Suzuki Tadaki, Hasegawa Hideki, Yasuda Shinsuke. 感染と免疫II　COVID-19の肥満患者における悪化の根本的なメカニズム(Infection and Immunity II　The underlying mechanism of the deterioration in obese patients with COVID-19). 日本免疫学会総会・学術集会記録 2022.11.01

  5. Yamaguchi Ayako, Hirata Shintaro, Miyamoto Toshiaki, Tanimura Kazuhide, Iwai Hideyuki, Kaneko Yuko, Takeuchi Tsutomu, Amano Koichi, Iwamoto Naoki, Kawakami Atsushi, Murakami Miho, Nishimoto Norihiro, Atsumi Tatsuya, Sumida Takayuki, Mimori Tsuneyo, Yamanaka Hisashi, Fujio Keishi, Nakano Kazuhisa, Tanaka Yoshiya. RAの治療戦略　RA患者における持続的寛解後のdrug-free寛解の可能性　FREE-J studyの2年間の成績、リアルワールド前向き観察コホート研究(Treatment strategy of RA　Possibility of drug free remission after sustained remission in patients with RA - The two-year results of the FREE-J study, a real world prospective observational cohort study). 日本リウマチ学会総会・学術集会プログラム・抄録集 2020.08.01

  6. Yamaguchi Ayako, Hirata Shintaro, Miyamoto Toshiaki, Tanimura Kazuhide, Iwai Hideyuki, Kaneko Yuko, Takeuchi Tsutomu, Amano Koichi, Iwamoto Naoki, Kawakami Atsushi, Murakami Miho, Nishimoto Norihiro, Atsumi Tatsuya, Sumida Takayuki, Mimori Tsuneyo, Yamanaka Hisashi, Fujio Keishi, Nakano Kazuhisa, Tanaka Yoshiya. RAの治療戦略　RA患者における持続的寛解後のdrug-free寛解の可能性　FREE-J studyの2年間の成績、リアルワールド前向き観察コホート研究(Treatment strategy of RA　Possibility of drug free remission after sustained remission in patients with RA - The two-year results of the FREE-J study, a real world prospective observational cohort study). 日本リウマチ学会総会・学術集会プログラム・抄録集 2020.08.01

  7. Yamaguchi Ayako, Hirata Shintaro, Miyamoto Toshiaki, Tanimura Kazuhide, Iwai Hideyuki, Kaneko Yuko, Takeuchi Tsutomu, Amano Koichi, Iwamoto Naoki, Kawakami Atsushi, Murakami Miho, Nishimoto Norihiro, Atsumi Tatsuya, Sumida Takayuki, Mimori Tsuneyo, Yamanaka Hisashi, Fujio Keishi, Nakano Kazuhisa, Tanaka Yoshiya. RAの治療戦略　RA患者における持続的寛解後のdrug-free寛解の可能性　FREE-J studyの2年間の成績、リアルワールド前向き観察コホート研究(Treatment strategy of RA　Possibility of drug free remission after sustained remission in patients with RA - The two-year results of the FREE-J study, a real world prospective observational cohort study). 日本リウマチ学会総会・学術集会プログラム・抄録集 2020.08.01

  8. Yamaguchi Ayako, Hirata Shintaro, Miyamoto Toshiaki, Tanimura Kazuhide, Iwai Hideyuki, Kaneko Yuko, Takeuchi Tsutomu, Amano Koichi, Iwamoto Naoki, Kawakami Atsushi, Murakami Miho, Nishimoto Norihiro, Atsumi Tatsuya, Sumida Takayuki, Mimori Tsuneyo, Yamanaka Hisashi, Fujio Keishi, Nakano Kazuhisa, Tanaka Yoshiya. RAの治療戦略　RA患者における持続的寛解後のdrug-free寛解の可能性　FREE-J studyの2年間の成績、リアルワールド前向き観察コホート研究(Treatment strategy of RA　Possibility of drug free remission after sustained remission in patients with RA - The two-year results of the FREE-J study, a real world prospective observational cohort study). 日本リウマチ学会総会・学術集会プログラム・抄録集 2020.08.01

  9. Yamaguchi Ayako, Hirata Shintaro, Miyamoto Toshiaki, Tanimura Kazuhide, Iwai Hideyuki, Kaneko Yuko, Takeuchi Tsutomu, Amano Koichi, Iwamoto Naoki, Kawakami Atsushi, Murakami Miho, Nishimoto Norihiro, Atsumi Tatsuya, Sumida Takayuki, Mimori Tsuneyo, Yamanaka Hisashi, Fujio Keishi, Nakano Kazuhisa, Tanaka Yoshiya. RAの治療戦略　RA患者における持続的寛解後のdrug-free寛解の可能性　FREE-J studyの2年間の成績、リアルワールド前向き観察コホート研究(Treatment strategy of RA　Possibility of drug free remission after sustained remission in patients with RA - The two-year results of the FREE-J study, a real world prospective observational cohort study). 日本リウマチ学会総会・学術集会プログラム・抄録集 2020.08.01

  10. Yamaguchi Ayako, Hirata Shintaro, Miyamoto Toshiaki, Tanimura Kazuhide, Iwai Hideyuki, Kaneko Yuko, Takeuchi Tsutomu, Amano Koichi, Iwamoto Naoki, Kawakami Atsushi, Murakami Miho, Nishimoto Norihiro, Atsumi Tatsuya, Sumida Takayuki, Mimori Tsuneyo, Yamanaka Hisashi, Fujio Keishi, Nakano Kazuhisa, Tanaka Yoshiya. RAの治療戦略　RA患者における持続的寛解後のdrug-free寛解の可能性　FREE-J studyの2年間の成績、リアルワールド前向き観察コホート研究(Treatment strategy of RA　Possibility of drug free remission after sustained remission in patients with RA - The two-year results of the FREE-J study, a real world prospective observational cohort study). 日本リウマチ学会総会・学術集会プログラム・抄録集 2020.08.01

  11. Yamaguchi Ayako, Hirata Shintaro, Miyamoto Toshiaki, Tanimura Kazuhide, Iwai Hideyuki, Kaneko Yuko, Takeuchi Tsutomu, Amano Koichi, Iwamoto Naoki, Kawakami Atsushi, Murakami Miho, Nishimoto Norihiro, Atsumi Tatsuya, Sumida Takayuki, Mimori Tsuneyo, Yamanaka Hisashi, Fujio Keishi, Nakano Kazuhisa, Tanaka Yoshiya. RAの治療戦略　RA患者における持続的寛解後のdrug-free寛解の可能性　FREE-J studyの2年間の成績、リアルワールド前向き観察コホート研究(Treatment strategy of RA　Possibility of drug free remission after sustained remission in patients with RA - The two-year results of the FREE-J study, a real world prospective observational cohort study). 日本リウマチ学会総会・学術集会プログラム・抄録集 2020.08.01

  12. Yamaguchi Ayako, Hirata Shintaro, Miyamoto Toshiaki, Tanimura Kazuhide, Iwai Hideyuki, Kaneko Yuko, Takeuchi Tsutomu, Amano Koichi, Iwamoto Naoki, Kawakami Atsushi, Murakami Miho, Nishimoto Norihiro, Atsumi Tatsuya, Sumida Takayuki, Mimori Tsuneyo, Yamanaka Hisashi, Fujio Keishi, Nakano Kazuhisa, Tanaka Yoshiya. RAの治療戦略　RA患者における持続的寛解後のdrug-free寛解の可能性　FREE-J studyの2年間の成績、リアルワールド前向き観察コホート研究(Treatment strategy of RA　Possibility of drug free remission after sustained remission in patients with RA - The two-year results of the FREE-J study, a real world prospective observational cohort study). 日本リウマチ学会総会・学術集会プログラム・抄録集 2020.08.01

  13. Yamaguchi Ayako, Hirata Shintaro, Miyamoto Toshiaki, Tanimura Kazuhide, Iwai Hideyuki, Kaneko Yuko, Takeuchi Tsutomu, Amano Koichi, Iwamoto Naoki, Kawakami Atsushi, Murakami Miho, Nishimoto Norihiro, Atsumi Tatsuya, Sumida Takayuki, Mimori Tsuneyo, Yamanaka Hisashi, Fujio Keishi, Nakano Kazuhisa, Tanaka Yoshiya. RAの治療戦略　RA患者における持続的寛解後のdrug-free寛解の可能性　FREE-J studyの2年間の成績、リアルワールド前向き観察コホート研究(Treatment strategy of RA　Possibility of drug free remission after sustained remission in patients with RA - The two-year results of the FREE-J study, a real world prospective observational cohort study). 日本リウマチ学会総会・学術集会プログラム・抄録集 2020.08.01

  14. Yamaguchi Ayako, Hirata Shintaro, Miyamoto Toshiaki, Tanimura Kazuhide, Iwai Hideyuki, Kaneko Yuko, Takeuchi Tsutomu, Amano Koichi, Iwamoto Naoki, Kawakami Atsushi, Murakami Miho, Nishimoto Norihiro, Atsumi Tatsuya, Sumida Takayuki, Mimori Tsuneyo, Yamanaka Hisashi, Fujio Keishi, Nakano Kazuhisa, Tanaka Yoshiya.. Treatment strategy of RA 　 Possibility of drug free remission after sustained remission in patients with RA - The two-year results of the FREE-J study, a real world prospective observational cohort study. 64th Annual General Assembly and Scientific Meeting of the Japan College of Rheumatology 2020.08

  15. Tsuyoshi Yamada, Hideyuki Iwai, Sayuri Nitta, Masakazu Nagahori, Masayoshi Harigai. Creating Medical Innovators – a Whole-brain Approach to Hea. the 13th Asia Pacific Medical Education Conference 2016.01.15 Singapore

  16. Tadashi Hosoya, Hideyuki Iwai, Yu Yamaguchi, Nobuyuki Miyasaka, Hitoshi Kohsaka. Cell cycle regulation therapy combined with cytokine blockade enhances anti-arthritic effects without increase of immune suppression.. 58th Annual General Assembly and Scientific Meeting of the Japan College of Rheumatology 2014.04.24 Tokyo

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Awards & Honors 【 display / non-display 】

  • MRCR Top Reviewer Award 2021，2022.03

  • MRCR Top Reviewer Award 2020，2021.03

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