Personnel Information

写真a

WAKABAYASHI Kenji


Job title

Professor

Laboratory Phone number

+81-3-5803-5959

Laboratory Fax number

+81-3-5803-0168

Mail Address

The inquiry by e-mail is 《here》

Research Areas, Keywords

Intensive Care Medicine, Acute Lung Injury, Extracorporeal Life Support, Acute Liver Failure, Extracellular Vesicles, Pediatrics

Profile

A physician scientist with strong interests in critical care research such as acute lung injury, bronchopulmonary dysplasia, acute liver failure, and extracellular vesicles.
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Graduating School 【 display / non-display 】

  • Tokyo Medical and Dental University, Faculty of Medicine, Department of Medicine, 2002.04, Graduated

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Graduate School 【 display / non-display 】

  • Imperial College London, Faculty of Medicine, Department of Surgery and Cancer, Academic Anaesthetics, Doctor's Course, 2012.08, Completed

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Degree 【 display / non-display 】

  • Doctor of Philosophy, Imperial College London

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Campus Career 【 display / non-display 】

  • 2002.04
    -
    2003.03
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Pediatrics, Maternal and Woman's Medicine， Pediatrics， Department of Pediatrics， Trainee Resident
  • 2013.09
    -
    2015.03
    Tokyo Medical and Dental University， Joint Institutes for Education and Research， International Exchange Center， Office for Global Education and Career Development， Project Assistant Professor
  • 2015.04
    -
    2018.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Comprehensive Patient Care， Intensive Care Medicine， Assistant Professor
  • 2018.04
    -
    2020.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Comprehensive Patient Care， Intensive Care Medicine， Assistant Professor
  • 2020.04
    -
    2021.09
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Comprehensive Patient Care， Intensive Care Medicine， Junior Associate Professor
  • 2021.10
    -
    2022.10
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Comprehensive Patient Care， Intensive Care Medicine， Professor
  • 2021.10
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Division of Comprehensive Patient Care， Department of Intensive Care Medicine， Professor
  • 2022.11
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Comprehensive Patient Care， Intensive Care Medicine， Professor

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External Career 【 display / non-display 】

  • 2003
    -
    2004
    Musashino Red Cross Hospital, Department of Pediatrics, Trainee Resident
  • 2004
    -
    2005
    Metropolitan Bokutoh Hospital, Deparment of Neonatology, Staff Physician
  • 2005
    -
    2007
    Tokyo-Kita Social Insurance Hospital (Current name: Tokyo-Kita Medical Center), Department of Pediatrics, Staff Physician
  • 2007
    -
    2012
    Imperial College London, Faculty of Medicine, Research Assistant
  • 2012
    -
    2013
    Imperial College London, Faculty of Medicine, Research Associate
  • 2013
    -
    Now
    Imperial College London, Faculty of Medicine, Honorary Research Associate
  • 2014
    -
    2015
    National Center for Child Health and Development, Department of Critical Care and Anesthesia, Division of Critical Care Medicine, Clinical Fellow
  • 2016
    -
    Now
    Tokyo Metropolitan Children's Medical Center, Department of Critical Care Medicine, Clinical Research Fellow (part-time)

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Academic Society Affiliations 【 display / non-display 】

  • Japan Pediatric Society

  • Japanese Society of Pediatric Intensive and Critical Care

  • The Japanese Society of Intensive Care Medicine

  • American Thoracic Society

  • Japanese Society of Respiratory Care Medicine

  • Japanese Society for Extracellular Vesicles

  • International Society for Extracellular Vesicles

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Academic Activity 【 display / non-display 】

  • 2016
    -
    Now
    The Japanese Study Group for Neonatal Basic and Translational Research Committee Member
  • 2017
    -
    Now
    Honjo International Scholarship Foundation Advisor
  • 2017
    -
    Now
    Kagakusha Net Advisor
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Research Areas 【 display / non-display 】

  • Intensive Care Medicine

  • Physiology

  • Clinical pharmacy

  • Embryonic medicine and pediatrics

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Qualification Acquired 【 display / non-display 】

  • Japanese board of intensive care medicine

  • Specialist license in Pediatrics

  • Doctor

  • Paediatric Immediate Life Support Course

  • FCCS provider

  • ACLS provider

  • PALS provider

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Research Theme 【 display / non-display 】

  • Clinical safety and usefulness of simple mechanical ventilator for pandmic use, 2020 - Now

  • The role and kinetics of microvesicles in pediatric liver diseases, 2020 - Now

  • Intestinal ventilation-based therapeutics development for COVID-19 related severe respiratory complications, 2020 - Now

  • Clinical significance of neutrophil-derived microvesicles in bronchopulmonary dysplasia, 2019 - Now

  • Impact of US-based system implementation in critical care, 2018 - Now

  • The role of microvesicles in organ injury in patients on ECMO, 2017 - Now

  • Effect of non-pharmacological intervention for delirium prevention, 2017 - Now

  • Investigation of the role and immunological mechanisms of microvesicles in bronchopulmonary dysplasia, 2016 - Now

  • Establishment of novel urinary biomarker in acute liver failure, 2016 - 2019

  • Role and charactristics of inflammation in bronchopulmonary dysplasia, 2014 - 2017

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Published Papers & Misc 【 display / non-display 】

  1. Goto Y, Nagamine Y, Hanafusa M, Kawahara T, Nawa N, Tateishi U, Ueki Y, Miyamae S, Wakabayashi K, Nosaka N, Miyazaki Y, Tohda S, Fujiwara T. Association of excess visceral fat and severe illness in hospitalized COVID-19 patients in Japan: a retrospective cohort study. International journal of obesity (2005). 2024.01; ( PubMed, DOI )

  2. Nosaka N, Wakabayashi K. Were you a family member, or a COVID-19 patient? Acute medicine & surgery. 2024.01; 11 (1): e947. ( PubMed, DOI )

  3. Hosoya T, Oba S, Komiya Y, Kawata D, Kamiya M, Iwai H, Miyamoto S, Kataoka M, Tobiume M, Kanno T, Ainai A, Sato H, Hirakawa A, Mitsui Y, Satoh T, Wakabayashi K, Yamada T, Otomo Y, Miyazaki Y, Hasegawa H, Suzuki T, Yasuda S. Apple-shaped obesity: A risky soil for cytokine-accelerated severity in COVID-19. Proceedings of the National Academy of Sciences of the United States of America. 2023.05; 120 (22): e2300155120. ( PubMed, DOI )

  4. Nosaka N, Anzai T, Uchimido R, Mishima Y, Takahashi K, Wakabayashi K. An anthropometric evidence against the use of age-based estimation of bodyweight in pediatric patients admitted to intensive care units. Scientific reports. 2023.03; 13 (1): 3574. ( PubMed, DOI )

  5. Maruyama F, Masuda T, Nosaka N, Wakabayashi K. Case of laryngeal venous malformations requiring repeated advanced airway management in the perioperative course. Clinical case reports. 2022.12; 10 (12): e6687. ( PubMed, DOI )

  6. Sakai T, Hoshino C, Okawa A, Wakabayashi K, Shigemitsu H. The Safety and Effect of Early Mobilization in the Intensive Care Unit According to Cancellation Criteria. Progress in rehabilitation medicine. 2020; 5 20200016. ( PubMed, DOI )

  7. Sakai Tomoko, Hoshino Chisato, Okawa Atsushi, Wakabayashi Kenji, Shigemitsu Hidenobu. The Safety and Effect of Early Mobilization in the Intensive Care Unit According to Cancellation Criteria(和訳中) Progress in Rehabilitation Medicine. 2020; 5 1-12. ( ichushi )

  8. Matsumoto, S; Iki, Y; Abe, M; O'Dea, KP; Shigemitsu, H; Takata, M; Wakabayashi, K. Neutrophil-Derived Microvesicles as a Novel Biomarker in Hyperoxic Bronchopulmonary Dysplasia in Mice AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2019; 199

  9. Tatham Kate Colette, O'Dea Kieran Patrick, Romano Rosalba, Donaldson Hannah Elizabeth, Kenji Wakabayashi, Patel Brijesh Vipin, Thakuria Louit, Simon Andre Rudiger, Sarathchandra Padmini, Marczin Nandor, Takata Masao. Intravascular donor monocytes play a central role in lung transplant ischaemia-reperfusion injury THORAX. 2018.04; 73 (4): 350-360. ( PubMed, DOI )

  10. Shiota Nobuhiro, Sato Sachiyo, Wakabayashi Kenji, Tanaka Marie, Tsukada Yoko, Asada Mizuho, Shigemitsu Hidenobu. 総合回診は日本の大学附属三次医療病院におけるICU滞在日数を短縮した(Multidisciplinary rounds shorten ICU length of stay in a Japanese university tertiary hospital) 日本集中治療医学会雑誌. 2018.02; 25 (Suppl.): ( ichushi )

  11. Tsukada Yoko, Tanaka Marie, Nishi Nao, Wakabayashi Kenji, Takahashi Hideo, Shigemitsu Hidenobu. 飲料制限は高度治療室における術後早期動作開始遅延と関連している(Fluid restriction is associated with delayed postoperative early mobilization in the high care unit) 日本集中治療医学会雑誌. 2018.02; 25 (Suppl.): ( ichushi )

  12. Shiota Nobuhiro, Sato Sachiyo, Wakabayashi Kenji, Tsukada Yoko, Tanaka Marie, Shigemitsu Hidenobu. MULTIDISCIPLINARY ROUNDS SHORTEN ICU LENGTH OF STAY IN A JAPANESE UNIVERSITY TERTIARY HOSPITAL CRITICAL CARE MEDICINE. 2018.01; 46 (1): 35. ( DOI )

  13. Mishima Y., Wakabayashi K., Shigemitsu H.. A Ten-Minute Lecture Impacted the Interpretation of Do-Not-Attempt-Resuscitation Order in Resident Physicians in Japan AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2018; 197

  14. Mitsui Y., Dea K. P. O., Uchida T., Takata M., Wakabayashi K.. Pro-Inflammatory Activity of Granulocyte-Derived Microvesicles Is Potentiated by Endotoxin Pre-Stimulation AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2018; 197

  15. Michael Wilson, Kenji Wakabayashi, Szabolcs Bertok, Charlotte Oakley, Brijesh Patel, Kieran O'Dea, Joanna Cordy, Peter Morley, Andrew Bayliffe and Masao Takata. Inhibition Of TNF Receptor p55 By A Domain Antibody Attenuates The Initial Phase Of Acid-Induced Lung Injury In Mice Frontiers in Immunology. 2017.02; ( DOI )

  16. Tatham, KC; O'Dea, KP; Romano, R; Donaldson, H; Thakuria, L; Wakabayashi, K; Patel, BV; Reed, A; Simon, A; Marczin, N; Takata, M. Retention And Activation Of Donor Vascular Monocytes In Transplanted Lungs Suggests A Central Role In Primary Graft Dysfunction AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2016; 193

  17. Takafumi Ohmori, Nobuhiro Shiota, Akihiro Haramo, Takahiro Masuda, Fumi Maruyama, Kenji Wakabayashi, Yushi U Adachi, Koichi Nakazawa. Post-operative cardiac arrest induced by co-administration of amiodarone and dexmedetomidine: a case report. J Intensive Care. 2015.10; 3 (10): 43. ( PubMed, DOI )

  18. Fletcher, ME; Boshier, PR; Wakabayashi, K; Keun, HC; Smolenski, RT; Kirkham, PA; Adcock, IM; Barton, PJ; Takata, M; Marczin, N. Influence of glutathione-<i>S</i>-transferase (GST) inhibition on lung epithelial cell injury: role of oxidative stress and metabolism AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2015.06; 308 (12): L1274-L1285. ( PubMed, DOI )

  19. Kate Tatham, Kieran O'Dea, Kenji Wakabayashi, Nandor Marczin, Masao Takata. The role of ex vivo lung perfusion in lung transplantation Journal of the Intensive Care Society. 2015.02; 16 (1): 58-63.

  20. Fletcher ME, Boshier PR, Wakabayashi K, Keun H, Smolenski RT, Kirkham PA, Adcock IM, Barton PJ, Takata M and Marczin N. Influence of glutathione-S-transferase (GST) inhibition on lung epithelial cell injury: role of oxidative stress and metabolism American Journal of Physiology - Lung Cellular and Molecular Physiology. 2015; 308 (12): 1274-1285.

  21. Kenji Wakabayashi, Michael R Wilson, Kate C Tatham, Kieran P O'Dea, Masao Takata. Volutrauma, but not atelectrauma, induces systemic cytokine production by lung-marginated monocytes. Critical Care Medicine. 2014.01; 42 (1): e49-e57. ( PubMed, DOI )

  22. Donaldson, H; Tatham, K; Odea, K; Wakabayashi, K; Marczin, N; Takata, M. Subclinical endotoxaemia enhances lung ischaemia-reperfusion injury BRITISH JOURNAL OF ANAESTHESIA. 2014.01; 112 (1): 184P-185P.

  23. Wakabayashi, K; Wilson, M; Tatham, K; O'Dea, K; Takata, M. High-stretch, but not atelectasis, causes systemic cytokine release by lung-marginated monocytes EUROPEAN RESPIRATORY JOURNAL. 2013.09; 42

  24. Tatham, K; Donaldson, H; O'Dea, K; Wakabayashi, K; Marczin, N; Takata, M. Marginated monocytes play a central role in lung ischaemia-reperfusion injury in mice: Implications for lung transplantation EUROPEAN RESPIRATORY JOURNAL. 2013.09; 42

  25. Anthony D Dorr, Michael R Wilson, Kenji Wakabayashi, Alicia C Waite, Brijesh V Patel, Nico van Rooijen, Kieran P O'Dea, Masao Takata. Sources of alveolar soluble TNF receptors during acute lung injury of different etiologies. Journal of Applied Physiology. 2011.07; 111 (1): 177-184. ( PubMed, DOI )

  26. Wakabayashi, K; Wilson, MR; O'Dea, KP; Takata, M. COMPARISON OF HIGH-STRETCH VERSUS ATELECTASIS IN THE PATHOPHYSIOLOGY OF VENTILATOR-INDUCED LUNG INJURY USING THE MOUSE ISOLATED PERFUSED LUNG THORAX. 2010.12; 65 A49-A50. ( DOI )

  27. Wakabayashi, K; Wilson, MR; O'Dea, KP; Takata, M. ROLE OF INTRAVASCULAR LEUCOCYTES IN VENTILATOR-INDUCED LUNG INJURY IN THE ISOLATED PERFUSED MOUSE LUNG THORAX. 2009.12; 64 A48-A49. ( DOI )

  28. Kieran P O'Dea, Michael R Wilson, Justina O Dokpesi, Kenji Wakabayashi, Louise Tatton, Nico van Rooijen, Masao Takata. Mobilization and margination of bone marrow Gr-1high monocytes during subclinical endotoxemia predisposes the lungs toward acute injury. Journal of Immunology. 2009.01; 182 (2): 1155-1166. ( PubMed, DOI )

  29. Dorr, AD; Wilson, MR; Wakabayashi, K; O'Dea, KP; Takata, M. INJURIOUS VENTILATION AND INTRATRACHEAL LIPOPOLYSACCHARIDE INCREASE SOLUBLE TUMOUR NECROSIS FACTOR RECEPTORS IN THE ALVEOLI VIA TWO DISTINCT MECHANISMS THORAX. 2008.12; 63 A71.

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Conference Activities & Talks 【 display / non-display 】

  1. Wakabayashi K, Sato S, Nawa N, Takezawa E, Fujiwara T, Shigemitsu H. Music interventions for preventing ICU delirium: a randomized controlled trial.. 32nd ESICM Annual Congress Berlin 2019.10.01 Berlin, Germany

  2. Matsumoto S, Iki Y, O'Dea KP, Shigemitsu H, Takata M, Wakabayashi K. Neutrophil-Derived Microvesicles as a Novel Biomarker in Hyperoxic Bronchopulmonary Dysplasia in Mice. American Thoracic Society Conference 2019 2019.05 Dallas, TX

  3. Yoichi Iki, Shotaro Matsumoto, Michiko Abe, Kieran P. O'Dea, Hidenobu Shigemitsu, Masao Takata, Kenji Wakabayashi. Microvesicles are absorbed on the surface of extracorporeal membrane oxygenation circuit tubing. Annual Meeting of International Society of Extracellular Vesicles 2019.04

  4. Y. Mishima, K. Wakabayashi, H. Shigemitsu. A Ten-minute Lecture Impacted the Interpretation of Do-Not-Attempt-Resuscitation Order in Resident Physicians in Japan. American Thoracic Society Conference 2018 2018.05.23 San Diego, CA

  5. Mitsui Y, O’Dea KP, Uchida T, Takata M, Wakabayashi K. Pro-inflammatory Activity of Granulocyte-derived Microvesicles is Potentiated by Endotoxin Pre-stimulation. American Thoracic Society Conference 2018 2018.05.22 San Diego, CA

  6. Kenji Wakabayashi, Tomoya Tateishi, Yushi Adachi, Naohiko Inase, Kochi Nakazawa. Ventilator settings and outcome of noninvasive and invasive ventilation for patients with acute respiratory failure on chronic interstitial lung disease. Ameritcan Thoracic Society International Conference 2016 2016.05 San Francisco, CA, USA

  7. Kajikawa Y, Hosokawa S, Wakabayashi K, Maejima Y, Isobe M, Doi S. Dexmedetomidine Ameliorates Monocrotaline Induced Pulmonary Arterial Hypertension in Rats. American Heart Association Scientific Sessions 2015 2015.11.10 Orland, USA

  8. Kenji Wakabayashi, Michael Wilson, Kate Tatham, Kieran O'Dea, Masao Takata. High-stretch, but not atelectasis, causes systemic cytokine release by lung-marginated monocytes. European Respiratory Society Annual Congress 2013.09 Barcelona, Spain

  9. Kenji Wakabayashi, Michael Wilison, Kieran O'Dea, Masao Takata. Inhibition of TNF receptor p55 by a domain antibody attenuates acid-induced lung injury in mice. American Thoracic Society International Conference 2013.05 Philadelphia, PA, USA

  10. Kenji Wakabayashi, Michael Wilson, Kieran O'Dea, Masao Takata. Atelectasis induces chemokine upregulation and lung injury in the isolated perfused mouse lung. American Thoracic Society International Conference 2011.05 Denver, CO, USA

  11. Kenji Wakabayashi, Michael Wilson, Kieran O'Dea, Masao Takata. Comparison of high-stretch versus atelectasis in the pathophysiology of ventilator-induced lung injury using the isolated perfused mouse lung. Winter Meeting of the British Thoracic Society 2010.12 London, United Kingdom

  12. Kenji Wakabayashi, Michael Wilson, Kieran O'Dea, Masao Takata. Role of intravascular leukocytes in ventilator-induced lung injury in the isolated perfused mouse lung. Winter Meeting of the British Thoracic Society 2009.12 London, United Kingdom

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Awards & Honors 【 display / non-display 】

  • International Trainee Scholarship，American Thoracic Society，2013

  • JRC Chelsea and Westminster Hospital Trust Travel Award，Chelsea and Westminster Hospital Trust，2011

  • The Japanese Students Scholarship (A graduate school student abroad)，Honjo International Scholarship Foundation，2008

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Campus class subject 【 display / non-display 】

  • Master, House Program，2018 - Now

  • Sub-master, House Program，2016 - 2018

  • Emergency Medicine and Anesthesia，2015 - Now

  • Tutor of Clinical Clerkship，2015 - 2017

  • Academic Skills for Successful Exchange Research sTudents (ASSERT)，2014

  • Health Sciences Leadership Program，2013 - 2014

  • Pre-clinical clerkship lecture, Clinical reasoning，2013

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External class subject 【 display / non-display 】

  • BSc programme, Department of Surgery and Cancer，Imperial College London

  • BSc research project, Department of Surgery and Cancer，Imperial College London

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Performance of duties 【 display / non-display 】

  • ，2020.07 - Now

  • Advisor to the Director, Medical Hospital，2020.04 - Now

  • Clinical Research Manager，2020.04 - 2021.03

  • Promoter, Open Innovation Institute，2019.09 - Now

  • ，2019

  • ，2017 - 2020

  • Working group for establishing international medical department，2017 - 2018

  • International Students Affair team, Institute of Global Affairs，2016 - Now

  • Tutor of Clinical Clerkship，2015 - 2017

  • Coordinator, TMDU-Imperial College exchange programme，2007.07 - Now

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Social Contribution 【 display / non-display 】

  • COVID-19: Our experience at TMDU，Imperial College Alumni Association Japan，2020.06.14

  • Kagakusha Net，2012 - 2014

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