Personnel Information

写真a

HAYASHI Mikihito


Job title

Associate Professor
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Graduating School 【 display / non-display 】

  • Tokyo University of Science, Faculty of Science and Engineering, 2004.03, Graduated

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Graduate School 【 display / non-display 】

  • Kyoto University, Graduate School, Division of Life Science, Master's Course, 2006.03, Completed

  • Tokyo Medical and Dental University, Doctor's Course, 2010.03, Completed

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Campus Career 【 display / non-display 】

  • 2013.06
    -
    2018.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Matrix， Cell Signaling， Assistant Professor
  • 2018.04
    -
    2020.06
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Matrix， Cell Signaling， Assistant Professor
  • 2020.07
    -
    2021.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Matrix， Cell Signaling， Assistant Professor
  • 2021.04
    -
    2024.09
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Matrix， Cell Signaling， Associate Professor
  • 2024.10
    -
    Now
    Institute of Science Tokyo， -， Graduate Schools， Bio-Matrix， Department of Cell Signaling， Associate Professor
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Research Areas 【 display / non-display 】

  • Oral biological science

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Published Papers & Misc 【 display / non-display 】

  1. Yu Yamashita, Mikihito Hayashi, Anhao Liu, Fumiyuki Sasaki, Yosuke Tsuchiya, Hiroshi Takayanagi, Mitsuru Saito, Tomoki Nakashima. Fam102a translocates Runx2 and Rbpjl to facilitate Osterix expression and bone formation. Nature Communications. 2025.01; 16 (1): 9. ( PubMed, DOI )

  2. Anhao Liu, Mikihito Hayashi, Yujin Ohsugi, Sayaka Katagiri, Shizuo Akira, Takanori Iwata, Tomoki Nakashima. The IL-33/ST2 axis is protective against acute inflammation during the course of periodontitis. Nature Communications. 2024.03; 15 (1): 2707. ( PubMed, DOI )

  3. Yu Yamashita, Mikihito Hayashi, Mitsuru Saito, Tomoki Nakashima. Osteoblast lineage cells-derived Sema3A regulates bone homeostasis independently of androgens Endocrinology. 2022.08; ( PubMed, DOI )

  4. Fumiyuki Sasaki, Mikihito Hayashi, Takehito Ono, Tomoki Nakashima.. The regulation of RANKL by mechanical force. Journal of Bone and Mineral Metabolism. 2021.01; 39 (1): 34-44. ( DOI )

  5. Nasir K. Bashiruddin, Mikihito Hayashi, Masanobu Nagano, Yan Wu, Yukiko Matsunaga, Junichi Takagi, Tomoki Nakashima, Hiroaki Suga. Development of cyclic peptides with potent in vivo osteogenic activity through RaPID-based affinity maturation. Proceedings of the National Academy of Sciences of the United States of America. 2020.12; 117 (49): 31070-31077. ( DOI )

  6. Yosuke Tsuchiya, Mikihito Hayashi, Katashi Nagamatsu, Takehito Ono, Masaki Kamakura, Takanori Iwata, Tomoki Nakashima. The key royal jelly component 10-hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-κB signaling downstream of FFAR4. Journal of Biological Chemistry. 2020.08; 385 (34): 12224-12232. ( DOI )

  7. Yoshitaka Kameo, Yuki Miya, Mikihito Hayashi, Tomoki Nakashima, Taiji Adachi. In silico experiments of bone remodeling explore metabolic diseases andtheir drug treatment. Science Advances. 2020.03; 6 (10): eaax0938.

  8. Takehito Ono, Mikihito Hayashi, Fumiyuki Sasaki, Tomoki Nakashima. RANKL biology: bone metabolism, the immune system, and beyond. Inflammation and Regeneration. 2020.02; 40 2. ( DOI )

  9. Fumiyuki Sasaki, Mikihito Hayashi, Yuki Mouri, Satoshi Nakamura, Taiji Adachi, Tomoki Nakashima. Mechanotransduction via the Piezo1-Akt pathway underlies Sost suppression in osteocytes. Biochemical and Biophysical Research Communications. 2020.01; 521 (3): 806-813.

  10. Mikihito Hayashi, Tomoki Nakashima, Noriko Yoshimura, Kazuo Okamoto, Sakae Tanaka, Hiroshi Takayanagi.. Osteocyte Sema3A orchestrates estrogen action and counteracts bone aging. Cell Metabolism. 2019.03; 29 627-637.

  11. Yusoon Kim, Mikihito Hayashi, Takehito Ono, Tetsuya Yoda, Hiroshi Takayanagi, Tomoki Nakashima.. Suppression of hematopoietic cell kinase ameliorates the bone destruction associated with inflammation. Modern Rheumatology. 2018.11;

  12. Yukano Fukushima-Nakayama, Takehito Ono, Mikihito Hayashi, Masamu Inoue, Hiroaki Wake, Takashi Ono, Tomoki Nakashima. Reduced Mastication Impairs Memory Function Journal of Dental Research. 2017.08; 96 (9): 1058-1066. ( PubMed )

  13. Ayumi Shoji-Matsunaga, Takehito Ono, Mikihito Hayashi, Hiroshi Takayanagi, Keiji Moriyama, Tomoki Nakashima. Osteocyte regulation of orthodontic force-mediated tooth movement via RANKL expression Scientific Reports. 2017.08; 7 (1): 8753. ( PubMed )

  14. Mikihito Hayashi, Tomoki Nakashima, Masahiko Taniguchi, Tatsuhiko Kodama, Atsushi Kumanogoh, Hiroshi Takayanagi. Osteoprotection by semaphorin 3A Nature. 2012.03; 485 (7396): 69-74. ( PubMed )

  15. Tomoki Nakashima, Mikihito Hayashi, Takanobu Fukunaga, Kosaku Kurata, Masatsugu Oh-Hora, Jian Q Feng, Lynda F Bonewald, Tatsuhiko Kodama, Anton Wutz, Erwin F Wagner, Josef M Penninger, Hiroshi Takayanagi. Evidence for osteocyte regulation of bone homeostasis through RANKL expression Nature Medicine. 2011.09; 17 (10): 1231-1234. ( PubMed )

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Conference Activities & Talks 【 display / non-display 】

  1. 林幹人. オステオネットワーク：骨による多臓器制御の現在. 第42回日本骨代謝学会学術集会 2024.06.30 沖縄県那覇市

  2. 林幹人. Autoregulation of osteocyte Sema3A counteracts bone aging.. Japan Bone Academy 2020 2020.11.23

  3. Mikihito Hayashi. Estrogen-miRNA-Sema3A-Nrp1 axis regulates bone mass through autoregulation of osteocyte. 第16回Bone Biology Forum 2019.08.17

  4. Mikihito Hayashi, Tomoki Nakashima, Hiroshi Takayanagi. Autoregulation of osteocyte through estrogen-miRNA-Sema3A-Nrp1 axis. ASBMR 2017 Annual Meeting 2017.09.08

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